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  2. Many factors influence whether the first-line oral anti-diabetic drug, metformin, should be initiated to a patient with type 2 diabetes mellitus (T2DM) early in the course of management in addition to lifestyl...

    Authors: Colman Siu Cheung Fung, Eric Yuk Fai Wan, Carlos King Ho Wong, Fangfang Jiao and Anca Ka Chun Chan
    Citation: Cardiovascular Diabetology 2015 14:137
    Content type: Original investigation Published on:

  3. Abdominal visceral obesity has been reported to be associated with cardiovascular risks than body mass index, waist circumference, and abdominal subcutaneous fat. On the other hand, there is evidence that subc...

    Authors: Ryotaro Bouchi, Takato Takeuchi, Momoko Akihisa, Norihiko Ohara, Yujiro Nakano, Rie Nishitani, Masanori Murakami, Tatsuya Fukuda, Masamichi Fujita, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto and Yoshihiro Ogawa
    Citation: Cardiovascular Diabetology 2015 14:136
    Content type: Original investigation Published on:

  4. Type 2 diabetes mellitus (DM) patients have worse adverse cardiovascular outcomes after Percutaneous Coronary Intervention (PCI). However, the adverse cardiovascular outcomes between insulin-treated and non-in...

    Authors: Pravesh Kumar Bundhun, Nuo Li and Meng-Hua Chen
    Citation: Cardiovascular Diabetology 2015 14:135
    Content type: Original investigation Published on:

  5. Diabetic cardiomyopathy (DCM), a fatal cardiovascular complication of diabetes mellitus, often leads to progressive heart failure, however its pathogenesis remains unclear. Corin, a cardiac serine protease, is...

    Authors: Aiming Pang, Yahui Hu, Pengfei Zhou, Guangfeng Long, Xin Tian, Li Men, Yanna Shen, Yunde Liu and Yujie Cui
    Citation: Cardiovascular Diabetology 2015 14:134
    Content type: Original investigation Published on:

  6. In order to influence every day clinical practice professional organisations issue management guidelines. Cross-sectional surveys are used to evaluate the implementation of such guidelines. The present survey ...

    Authors: Viveca Gyberg, Dirk De Bacquer, Guy De Backer, Catriona Jennings, Kornelia Kotseva, Linda Mellbin, Oliver Schnell, Jaakko Tuomilehto, David Wood, Lars Rydén, Philippe Amouyel, Jan Bruthans, Almudena Castro Conde, Renata Cifkova, Jaap W. Deckers, Johan De Sutter…
    Citation: Cardiovascular Diabetology 2015 14:133
    Content type: Original investigation Published on:

  7. The purpose of this study was to analyze the evolution of vascular, cardiac and renal target organ damage (TOD) in patients with increased insulin resistance over a 3.5 year follow-up and to investigate gender...

    Authors: Manuel Ángel Gómez-Marcos, José Ignacio Recio-Rodríguez, Leticia Gómez-Sánchez, Cristina Agudo-Conde, Emiliano Rodríguez-Sanchez, JoseAngel Maderuelo-Fernandez, Marta Gomez-Sanchez and Luís García-Ortiz
    Citation: Cardiovascular Diabetology 2015 14:132
    Content type: Original investigation Published on:

  8. Diabetes mellitus (DM) and aortic stenosis (AS) are frequent findings in the elderly population. Data regarding the influence of DM on the outcomes of patients undergoing transcatheter aortic valve replacemen...

    Authors: Anat Berkovitch, Amit Segev, Israel Barbash, Yoni Grossman, Elad Maor, Aharon Erez, Ehud Regev, Noam Fink, Israel Mazin, Ashraf Hamdan, Ilan Goldenberg, Ilan Hay, Dan Spiegelstien, Victor Guetta and Paul Fefer
    Citation: Cardiovascular Diabetology 2015 14:131
    Content type: Original investigation Published on:

  9. Increased cardiac fat has been identified as a risk factor for coronary artery disease. Metabolic syndrome is associated with increased cardiac fat deposition. Steroids are known to imitate some effects of met...

    Authors: Daniel Kitterer, Joerg Latus, Joerg Henes, Stefan Birkmeier, Maik Backes, Niko Braun, Udo Sechtem, M. Dominik Alscher, Heiko Mahrholdt and Simon Greulich
    Citation: Cardiovascular Diabetology 2015 14:130
    Content type: Original investigation Published on:

  11. Authors: Stijn A Peeters, Lian Engelen, Jacqueline Buijs, Nish Chaturvedi, John H Fuller, Casper G Schalkwijk and Coen D Stehouwer
    Citation: Cardiovascular Diabetology 2015 14:128
    Content type: Erratum Published on:

    The original article was published in Cardiovascular Diabetology 2015 14:31

  12. Cardiomyopathy is a devastating complication of obesity and type 2 diabetes mellitus (T2DM). It arises even in patients with normoglycemia (glycosylated hemoglobin, A1C ≤7 %). As obesity and T2DM are approachi...

    Authors: Nathan W. Roberts, Magdalis González-Vega, Tirsit K. Berhanu, Aaron Mull, Jesús García and Ahlke Heydemann
    Citation: Cardiovascular Diabetology 2015 14:127
    Content type: Original investigation Published on:

  13. Advanced glycation end products (AGEs) play a role in the development of late complications and atherosclerosis in diabetes by engaging the receptor for advanced glycation end products, RAGE. Receptor binding ...

    Authors: Martin Heier, Hanna Dis Margeirsdottir, Mario Gaarder, Knut Haakon Stensæth, Cathrine Brunborg, Peter Abusdal Torjesen, Ingebjørg Seljeflot, Kristian Folkvord Hanssen and Knut Dahl-Jørgensen
    Citation: Cardiovascular Diabetology 2015 14:126
    Content type: Original investigation Published on:

  14. IL-1β was considered as an important inflammatory cytokine in diabetic cardiovascular complications. DCM is one of the major manifestations of diabetic cardiovascular complications whose specific mechanisms ar...

    Authors: Zhongwei Liu, Na Zhao, Huolan Zhu, Shunming Zhu, Shuo Pan, Jing Xu, Xuejun Zhang, Yong Zhang and Junkui Wang
    Citation: Cardiovascular Diabetology 2015 14:125
    Content type: Original investigation Published on:

  15. Whether lowering glycosylated haemoglobin (HbA1c) level below 7.0 % improves macro-vascular outcomes in diabetes remains unclear. Here, we aimed to assess the effect of relatively tight glucose control resulti...

    Authors: Pin Wang, Rong Huang, Sen Lu, Wenqing Xia, Haixia Sun, Jie Sun, Rongrong Cai and Shaohua Wang
    Citation: Cardiovascular Diabetology 2015 14:124
    Content type: Original investigation Published on:

  16. Type 2 diabetes mellitus (T2DM) complicated by retinopathy is associated with altered left ventricular (LV) structure and resting myocardial dysfunction unlike T2DM without retinopathy. The myocardial response...

    Authors: Zhe Zhen, Yan Chen, Kendrick Shih, Ju-Hua Liu, Michele Yuen, David Sai-Hung Wong, Karen Siu-Ling Lam, Hung-Fat Tse and Kai-Hang Yiu
    Citation: Cardiovascular Diabetology 2015 14:123
    Content type: Original investigation Published on:

  17. Whole body cardiovascular MR (WB CVMR) combines whole body angiography and cardiac MR assessment. It is accepted that there is a high disease burden in patients with diabetes, however the quantification of the...

    Authors: Suzanne L. Duce, Jonathan R. Weir-McCall, Stephen J. Gandy, Shona Z. Matthew, Deirdre B. Cassidy, Lynne McCormick, Petra Rauchhaus, Helen Looker, Helen M. Colhoun and J. Graeme Houston
    Citation: Cardiovascular Diabetology 2015 14:122
    Content type: Original investigation Published on:

  18. The glycoprotein YKL-40 is a new marker of early inflammation and endothelial dysfunction. Adiponectin is a collagen-like protein with anti-atherogenic and anti-inflammatory effects. Increased concentrations o...

    Authors: Eva Aguilera, Enric Serra-Planas, M. Luisa Granada, Silvia Pellitero, Jordi L. Reverter, Núria Alonso, Berta Soldevila, Dídac Mauricio and Manel Puig-Domingo
    Citation: Cardiovascular Diabetology 2015 14:121
    Content type: Original investigation Published on:

  19. Diabetes and impaired glucose tolerance (IGT) are major risk factors for atherosclerosis including coronary artery disease (CAD). The present study’s aim was to investigate the importance of glucose tolerance ...

    Authors: Jeanette Kuhl, Gun Jörneskog, Malin Wemminger, Mattias Bengtsson, Pia Lundman and Majid Kalani
    Citation: Cardiovascular Diabetology 2015 14:120
    Content type: Original investigation Published on:

  20. Left ventricular (LV) diastolic dysfunction (LVDD) is a well-established and early echocardiographic characteristic of diabetic cardiomyopathy. However, there are limited data on the association between impair...

    Authors: Assi Milwidsky, Elad Maor, Shaye Kivity, Anat Berkovitch, Sagit Ben Zekry, Alexander Tenenbaum, Enrique Z. Fisman, Aharon Erez, Shlomo Segev, Yechezkel Sidi, Ilan Goldenberg and Rafael Kuperstein
    Citation: Cardiovascular Diabetology 2015 14:119
    Content type: Original investigation Published on:

  21. We recently reported strong associations between eight skin collagen AGEs and two solubility markers from skin biopsies obtained at DCCT study closeout and the long-term progression of microvascular disease in...

    Authors: Vincent M Monnier, Wanjie Sun, Xiaoyu Gao, David R Sell, Patricia A Cleary, John M Lachin and Saul Genuth
    Citation: Cardiovascular Diabetology 2015 14:118
    Content type: Original investigation Published on:

    The Erratum to this article has been published in Cardiovascular Diabetology 2015 14:138

  22. It has been shown that visceral fat accumulation is associated with autonomic dysfunction, though the precise mechanism remains unclear. A recent basic study found that leptin can directly modulate autonomic f...

    Authors: Masafumi Kurajoh, Hidenori Koyama, Manabu Kadoya, Mariko Naka, Akio Miyoshi, Akinori Kanzaki, Miki Kakutani-Hatayama, Hirokazu Okazaki, Takuhito Shoji, Yuji Moriwaki, Tetsuya Yamamoto, Masanori Emoto, Masaaki Inaba and Mitsuyoshi Namba
    Citation: Cardiovascular Diabetology 2015 14:117
    Content type: Original investigation Published on:

  23. The risk of cardiovascular morbidity and mortality is significantly increased in patients with diabetes; thus, it is important to determine whether glucose-lowering therapy affects this risk over time. Changes...

    Authors: Rafael Simó, Bruno Guerci, Guntram Schernthaner, Baptist Gallwitz, Juan Rosas-Guzmàn, Francesco Dotta, Andreas Festa, Ming Zhou and Jacek Kiljański
    Citation: Cardiovascular Diabetology 2015 14:116
    Content type: Original investigation Published on:

  25. Hyperglycemia is the hallmark of diabetes and its cardiovascular complications. Insulin plays an important role in the regulation of vascular homeostasis and maintenance of endothelial function. Insulin signal...

    Authors: Valeria De Nigris, Gemma Pujadas, Lucia La Sala, Roberto Testa, Stefano Genovese and Antonio Ceriello
    Citation: Cardiovascular Diabetology 2015 14:114
    Content type: Original investigation Published on:

  26. The hyperinsulinemia of obesity is a function of both increased pancreatic insulin secretion and decreased insulin clearance, and contributes to cardiovascular risk. Whilst weight loss is known to enhance insu...

    Authors: Nora E. Straznicky, Mariee T. Grima, Carolina I. Sari, Elisabeth A. Lambert, Sarah E. Phillips, Nina Eikelis, Daisuke Kobayashi, Dagmara Hering, Justin A. Mariani, John B. Dixon, Paul J. Nestel, Sofie Karapanagiotidis, Markus P. Schlaich and Gavin W. Lambert
    Citation: Cardiovascular Diabetology 2015 14:113
    Content type: Original investigation Published on:

  27. Betatrophin has been suggested as an inducer of β-cell proliferation in mice in addition to its function in regulating triglyceride. Recent data showed that betatrophin was increased in Type 2 Diabetes (T2D), ...

    Authors: Mohamed Abu-Farha, Jehad Abubaker, Fiona Noronha, Irina Al-Khairi, Preethi Cherian, Monira Alarouj, Abdullah Bennakhi and Naser Elkum
    Citation: Cardiovascular Diabetology 2015 14:112
    Content type: Original investigation Published on:

  28. Blood glucose variability is receiving considerable attention as a new risk factor for coronary artery disease. This study aimed to investigate the association between blood glucose variability and coronary pl...

    Authors: Kozo Okada, Kiyoshi Hibi, Masaomi Gohbara, Shunsuke Kataoka, Keiko Takano, Eiichi Akiyama, Yasushi Matsuzawa, Kenichiro Saka, Nobuhiko Maejima, Mitsuaki Endo, Noriaki Iwahashi, Kengo Tsukahara, Masami Kosuge, Toshiaki Ebina, Peter J. Fitzgerald, Yasuhiro Honda…
    Citation: Cardiovascular Diabetology 2015 14:111
    Content type: Original investigation Published on:

  29. The Global Registry of Acute Coronary Events (GRACE) risk score is widely recommended for risk assessment in patients with acute coronary syndrome (ACS). Chronic hyperglycemia [hemoglobinA1c (HbA1c)] can indep...

    Authors: Xiao-Jun Liu, Zhao-Fei Wan, Na Zhao, Ya-Ping Zhang, Lan Mi, Xin-Hong Wang, Dong Zhou, Yan Wu and Zu-Yi Yuan
    Citation: Cardiovascular Diabetology 2015 14:110
    Content type: Original investigation Published on:

  31. With the increasing trend of metabolic syndrome (MetS) and atherothrombotic stroke (which can manifest as stroke lesion multiplicity), studies on the association between MetS and the clinical aspects of athero...

    Authors: Kazuhiko Kotani, Noriko Satoh-Asahara, Takuya Nakakuki, Hajime Yamakage, Akira Shimatsu and Tetsuya Tsukahara
    Citation: Cardiovascular Diabetology 2015 14:108
    Content type: Original investigation Published on:

  32. We previously showed that unesterified-cholesterol transfer to high-density lipoprotein (HDL), a crucial step in cholesterol esterification and role in reverse cholesterol transport, was diminished in non-diab...

    Authors: Marilia C O Sprandel, Whady A Hueb, Alexandre Segre, José A F Ramires, Roberto Kalil-Filho and Raul C Maranhão
    Citation: Cardiovascular Diabetology 2015 14:107
    Content type: Original investigation Published on:

  33. Coronary microvascular dysfunction (CMD) is associated with cardiovascular events in type 2 diabetes mellitus (T2DM). Optimal glycaemic control does not always preclude future events. We sought to assess the e...

    Authors: Luis Felipe Valenzuela-Garcia, Yasushi Matsuzawa, Jaskanwal D S Sara, Taek-Geun Kwon, Ryan J Lennon, Lilach O Lerman, Rafael J Ruiz-Salmeron and Amir Lerman
    Citation: Cardiovascular Diabetology 2015 14:106
    Content type: Original investigation Published on:

  34. Studies on the long-term effectiveness of multidisciplinary risk-stratification based management in Chinese population were rare. This study aimed to evaluate the effectiveness of a multidisciplinary risk ass...

    Authors: Fangfang Jiao, Colman Siu Cheung Fung, Yuk Fai Wan, Sarah Morag McGhee, Carlos King Ho Wong, Daisy Dai, Ruby Kwok and Cindy Lo Kuen Lam
    Citation: Cardiovascular Diabetology 2015 14:105
    Content type: Original investigation Published on:

  35. Vascular calcification is an independent risk factor for cardiovascular disease. Diabetes mellitus increases the incidence of vascular calcification; however, detailed molecular mechanisms of vascular calcific...

    Authors: Yuya Terao, Seimi Satomi-Kobayashi, Ken-ichi Hirata and Yoshiyuki Rikitake
    Citation: Cardiovascular Diabetology 2015 14:104
    Content type: Original investigation Published on:

  36. Type 2 diabetes mellitus (T2DM) worsens the outcome after myocardial infarction (MI). Here, we hypothesized that inhibition of dipeptidyl peptidase-4 (DPP-4) improves survival after MI in T2DM by modifying aut...

    Authors: Hiromichi Murase, Atsushi Kuno, Takayuki Miki, Masaya Tanno, Toshiyuki Yano, Hidemichi Kouzu, Satoko Ishikawa, Toshiyuki Tobisawa, Makoto Ogasawara, Keitaro Nishizawa and Tetsuji Miura
    Citation: Cardiovascular Diabetology 2015 14:103
    Content type: Original investigation Published on:

  37. Enhancement of myocardial glucose uptake may reduce fatty acid oxidation and improve tolerance to ischemia. Hyperglycemia, in association with hyperinsulinemia, stimulates this metabolic change but may have d...

    Authors: Liam M McCormick, Patrick M Heck, Liam S Ring, Anna C Kydd, Sophie J Clarke, Stephen P Hoole and David P Dutka
    Citation: Cardiovascular Diabetology 2015 14:102
    Content type: Original investigation Published on:

  38. Obesity is a recognized risk factor for various cardiometabolic diseases and several indices are used clinically to assess overall cardiometabolic risk. This study aims to determine the sensitivity of six anth...

    Authors: Nasser M Al-Daghri, Omar S Al-Attas, Kaiser Wani, Abdullah M Alnaami, Shaun Sabico, Abdulrahman Al-Ajlan, George P Chrousos and Majed S Alokail
    Citation: Cardiovascular Diabetology 2015 14:101
    Content type: Original investigation Published on:

  39. The aim of the study was to evaluate the effect of delay in treatment intensification (IT; clinical inertia) in conjunction with glycaemic burden on the risk of macrovascular events (CVE) in type 2 diabetes (T...

    Authors: Sanjoy K Paul, Kerenaftali Klein, Brian L Thorsted, Michael L Wolden and Kamlesh Khunti
    Citation: Cardiovascular Diabetology 2015 14:100
    Content type: Original investigation Published on:

  40. Recent evidence indicates that inhibition of histone deacetylase (HDAC) protects the heart against myocardial injury and stimulates endogenous angiomyogenesis. However, it remains unknown whether HDAC inhibiti...

    Authors: Youfang Chen, Jianfeng Du, Yu Tina Zhao, Ling Zhang, Guorong Lv, Shougang Zhuang, Gangjian Qin and Ting C Zhao
    Citation: Cardiovascular Diabetology 2015 14:99
    Content type: Original investigation Published on:

  41. Left ventricular (LV) diastolic dysfunction is known as an early marker of myocardial alterations in patients with diabetes. Because microvascular disease has been regarded as an important cause of heart failu...

    Authors: Takayuki Kawata, Masao Daimon, Sakiko Miyazaki, Ryoko Ichikawa, Masaki Maruyama, Shuo-Ju Chiang, Chiharu Ito, Fumihiko Sato, Hirotaka Watada and Hiroyuki Daida
    Citation: Cardiovascular Diabetology 2015 14:98
    Content type: Original investigation Published on:

  42. In diabetes mellitus the morbidity and mortality of cardiovascular disease is increased and represents an important independent mechanism by which heart disease is exacerbated. The pathogenesis of diabetic car...

    Authors: Jun He, Megan T Quintana, Jenyth Sullivan, Traci L Parry, Trisha J Grevengoed, Jonathan C Schisler, Joseph A Hill, Cecelia C Yates, Rudo F Mapanga, M Faadiel Essop, William E Stansfield, James R Bain, Christopher B Newgard, Michael J Muehlbauer, Yipin Han, Brian A Clarke…
    Citation: Cardiovascular Diabetology 2015 14:97
    Content type: Original investigation Published on:

  44. To evaluate the relevance of adding acetylsalicylic acid (ASA) in primary prevention in subjects with type 2 diabetes mellitus.

    Authors: Giuseppe Derosa, Amedeo Mugellini, Rosa M Pesce, Angela D’Angelo and Pamela Maffioli
    Citation: Cardiovascular Diabetology 2015 14:95
    Content type: Original investigation Published on:

  45. Acute hyperglycemia co-presenting with myocardial infarction (in diabetic and non-diabetic individuals) is often associated with a poor prognosis. Although acute hyperglycemia induces oxidative stress that can...

    Authors: Buin Adams, Rudo F Mapanga and M Faadiel Essop
    Citation: Cardiovascular Diabetology 2015 14:94
    Content type: Original investigation Published on:

  46. Patients with type 2 diabetes have a high risk for early and extensive development of peripheral arterial disease (PAD) and this excess risk is not explained by increased burden of traditional atherosclerotic ...

    Authors: Jonas Malmstedt, Lars Kärvestedt, Jesper Swedenborg and Kerstin Brismar
    Citation: Cardiovascular Diabetology 2015 14:93
    Content type: Original investigation Published on:

  47. Impaired actin–myosin cross-bridge (CB) dynamics correlate with impaired left ventricular (LV) function in early diabetic cardiomyopathy (DCM). Elevated expression and activity of Rho kinase (ROCK) contributes...

    Authors: Mark T Waddingham, Amanda J Edgley, Alberto Astolfo, Tadakatsu Inagaki, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Hirotsugu Tsuchimochi, Naoto Yagi, Darren J Kelly, Mikiyasu Shirai and James T Pearson
    Citation: Cardiovascular Diabetology 2015 14:92
    Content type: Original investigation Published on:

  48. Insulin-induced microvascular recruitment is important for optimal muscle glucose uptake. 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR, an activator of AMP-activated protein kinase), can also induce...

    Authors: Eloise A Bradley, Lei Zhang, Amanda J Genders, Stephen M Richards, Stephen Rattigan and Michelle A Keske
    Citation: Cardiovascular Diabetology 2015 14:91
    Content type: Original investigation Published on:

  49. Oxidative stress plays a major role in diabetic cardiomyopathy pathogenesis. Anti-oxidant therapy has been investigated in preventing or treating several diabetic complications. However, anti-oxidant action on...

    Authors: Julliano F C Guimaraes, Bruno P Muzio, Camila M Rosa, Andre F Nascimento, Mario M Sugizaki, Ana A H Fernandes, Antonio C Cicogna, Carlos R Padovani, Marina P Okoshi and Katashi Okoshi
    Citation: Cardiovascular Diabetology 2015 14:90
    Content type: Original investigation Published on:

  50. Skin autofluorescence is a non-invasive measurement of advanced glycation end products (AGE), which are suggested to be one of the major agents in the pathogenesis and progression of diabetes related cardiovas...

    Authors: Y H M Krul-Poel, R Agca, P Lips, H van Wijland, F Stam and S Simsek
    Citation: Cardiovascular Diabetology 2015 14:89
    Content type: Original investigation Published on:
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Cardiovascular Diabetology

ISSN: 1475-2840