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  1. Original investigation

    Human epicardial adipose tissue-derived and circulating secreted frizzled-related protein 4 (SFRP4) levels are increased in patients with coronary artery disease

    Previous studies have demonstrated that secreted frizzled-related protein 4 (SFRP4) is associated with impaired glucose and triglyceride metabolism in patients with stable coronary artery disease. In the prese...

    Qingwei Ji, Jianwei Zhang, Yu Du, Enjun Zhu, Zhijian Wang, Bin Que, Huangtai Miao, Shutian Shi, Xiuchuan Qin, Yingxin Zhao, Yujie Zhou, Fangjun Huang and Shaoping Nie

    Cardiovascular Diabetology 2017 16:133

    Published on: 16 October 2017

  2. Review

    Pioglitazone and the secondary prevention of cardiovascular disease. A meta-analysis of randomized-controlled trials

    Pioglitazone targets multiple pathogenic pathways involved in the development of cardiovascular diseases (CVD). The aim of this systematic review and meta-analysis is to assess the effects of pioglitazone trea...

    Marit de Jong, H. Bart van der Worp, Yolanda van der Graaf, Frank L. J. Visseren and Jan Westerink

    Cardiovascular Diabetology 2017 16:134

    Published on: 16 October 2017

  3. Original investigation

    The anti-inflammatory function of HDL is impaired in type 2 diabetes: role of hyperglycemia, paraoxonase-1 and low grade inflammation

    Functional properties of high density lipoproteins (HDL) are increasingly recognized to play a physiological role in atheroprotection. Type 2 diabetes mellitus (T2DM) is characterized by low HDL cholesterol, b...

    Sanam Ebtehaj, Eke G. Gruppen, Mojtaba Parvizi, Uwe J. F. Tietge and Robin P. F. Dullaart

    Cardiovascular Diabetology 2017 16:132

    Published on: 12 October 2017

  4. Original investigation

    Impact of renal function on the underlying pathophysiology of coronary plaque composition in patients with type 2 diabetes mellitus

    Both the progression of diabetic kidney disease and increased glycemic variability play important roles in the pathogenesis of coronary plaque formation via inflammatory pathways in patients with type 2 diabet...

    Kentaro Kakuta, Kaoru Dohi, Miho Miyoshi, Takashi Yamanaka, Masaki Kawamura, Jun Masuda, Tairo Kurita, Toru Ogura, Norikazu Yamada, Yasuhiro Sumida and Masaaki Ito

    Cardiovascular Diabetology 2017 16:131

    Published on: 12 October 2017

  5. Study Protocol

    Impact of empagliflozin on subclinical left ventricular dysfunctions and on the mechanisms involved in myocardial disease progression in type 2 diabetes: rationale and design of the EMPA-HEART trial

    Asymptomatic left ventricular (LV) dysfunction is highly prevalent in type 2 diabetes patients. Unlike the other hypoglycemic drugs, SGLT2 inhibitors have shown potential benefits for reducing cardiovascular d...

    Andrea Natali, Lorenzo Nesti, Iacopo Fabiani, Enrico Calogero and Vitantonio Di Bello

    Cardiovascular Diabetology 2017 16:130

    Published on: 12 October 2017

  6. Review

    Updates on cardiovascular outcome trials in diabetes

    In 2008 the Food and Drug Administration introduced a guidance for industry that requires the investigation of cardiovascular outcomes of glucose-lowering medications. Since then, an increasing number of cardi...

    Oliver Schnell, Lars Rydén, Eberhard Standl and Antonio Ceriello

    Cardiovascular Diabetology 2017 16:128

    Published on: 11 October 2017

  7. Original investigation

    The effects of vildagliptin compared with metformin on vascular endothelial function and metabolic parameters: a randomized, controlled trial (Sapporo Athero-Incretin Study 3)

    Dipeptidyl peptidase-4 (DPP-4) inhibitors may have protective effects in the early stage of atherosclerosis in patients with type 2 diabetes, although similar effects in advanced atherosclerosis were not shown...

    Naoyuki Kitao, Hideaki Miyoshi, Tomoo Furumoto, Kota Ono, Hiroshi Nomoto, Aika Miya, Chiho Yamamoto, Atsushi Inoue, Kenichi Tsuchida, Naoki Manda, Yoshio Kurihara, Shin Aoki, Akinobu Nakamura and Tatsuya Atsumi

    Cardiovascular Diabetology 2017 16:125

    Published on: 10 October 2017

  8. Original investigation

    Glycated albumin and its variability as an indicator of cardiovascular autonomic neuropathy development in type 2 diabetic patients

    We investigated whether glycated albumin (GA) and its variability are associated with cardiovascular autonomic neuropathy (CAN) and further compared their associations with glycated hemoglobin (HbA1c).

    Ji Eun Jun, Seung-Eun Lee, You-Bin Lee, Ji Yeon Ahn, Gyuri Kim, Sang-Man Jin, Kyu Yeon Hur, Moon-Kyu Lee and Jae Hyeon Kim

    Cardiovascular Diabetology 2017 16:127

    Published on: 10 October 2017

  9. Original investigation

    Impact of type 2 diabetes mellitus on in-hospital-mortality after major cardiovascular events in Spain (2002–2014)

    Diabetes mellitus has long been associated with cardiovascular events. Nevertheless, the higher burden of traditional cardiovascular risk factors reported in high-income countries is offset by a more widesprea...

    José M. de Miguel-Yanes, Rodrigo Jiménez-García, Valentín Hernández-Barrera, Manuel Méndez-Bailón, Javier de Miguel-Díez and Ana Lopez-de-Andrés

    Cardiovascular Diabetology 2017 16:126

    Published on: 10 October 2017

  10. Original investigation

    The role of endothelial nitric oxide in the anti-restenotic effects of liraglutide in a mouse model of restenosis

    Previous animal studies have shown that glucagon-like peptide-1 receptor agonists (GLP-1RAs) suppress arterial restenosis, a major complication of angioplasty, presumably through their direct action on vascula...

    Hideki Kushima, Yusaku Mori, Masakazu Koshibu, Munenori Hiromura, Kyoko Kohashi, Michishige Terasaki, Tomoyasu Fukui and Tsutomu Hirano

    Cardiovascular Diabetology 2017 16:122

    Published on: 2 October 2017

  11. Original investigation

    Relation between low-density lipoprotein cholesterol/apolipoprotein B ratio and triglyceride-rich lipoproteins in patients with coronary artery disease and type 2 diabetes mellitus: a cross-sectional study

    The low-density lipoprotein cholesterol/apolipoprotein B (LDL-C/apoB) ratio has conventionally been used as an index of the LDL-particle size. Smaller LDL-particle size is associated with triglyceride (TG) met...

    Shigemasa Tani, Tsukasa Yagi, Wataru Atsumi, Kenji Kawauchi, Rei Matsuo and Atsushi Hirayama

    Cardiovascular Diabetology 2017 16:123

    Published on: 2 October 2017

  12. Original investigation

    High-density lipoproteins attenuate high glucose-impaired endothelial cell signaling and functions: potential implications for improved vascular repair in diabetes

    Abnormalities of endothelial cell function are proposed to be a critical factor underlying adverse cardiovascular outcomes in the setting of hyperglycaemia. While high-density lipoproteins (HDL) have been demo...

    Xing Chen, My-Ngan Duong, Peter J. Psaltis, Christina A. Bursill and Stephen J. Nicholls

    Cardiovascular Diabetology 2017 16:121

    Published on: 29 September 2017

  13. Original investigation

    NTproBNP in insulin-resistance mediated conditions: overweight/obesity, metabolic syndrome and diabetes. The population-based Casale Monferrato Study

    NTproBNP and BNP levels are reduced in obese subjects, but population-based data comparing the pattern of this relationship in the full spectrum of insulin-resistance mediated conditions, overweight/obesity, m...

    Stefano Baldassarre, Salvatore Fragapani, Antonio Panero, Debora Fedele, Silvia Pinach, Manuela Lucchiari, Anna Rita Vitale, Giulio Mengozzi, Gabriella Gruden and Graziella Bruno

    Cardiovascular Diabetology 2017 16:119

    Published on: 25 September 2017

  14. Original investigation

    Circulating levels and characterization of microparticles in patients with different degrees of glucose tolerance

    Microparticles (MPs) are vesicular structures shed from endothelial or circulating blood cells, after activation or apoptosis, and can be considered markers of vascular damage. We aimed to determine the levels...

    Alessandra Giannella, Claudia Maria Radu, Lorenzo Franco, Elena Campello, Paolo Simioni, Angelo Avogaro, Saula Vigili de Kreutzenberg and Giulio Ceolotto

    Cardiovascular Diabetology 2017 16:118

    Published on: 19 September 2017

  15. Erratum

    Erratum to: Changes in proteinuria and the risk of myocardial infarction in people with diabetes or pre-diabetes: a prospective cohort study

    Following publication of the original article [1], the authors reported that figure 2 had not been replaced with the correct figure as indicated in the proofs.

    Anxin Wang, Yang Sun, Xiaoxue Liu, Zhaoping Su, Junjuan Li, Yanxia Luo, Shuohua Chen, Jianli Wang, Xia Li, Zhan Zhao, Huiping Zhu, Shouling Wu and Xiuhua Guo

    Cardiovascular Diabetology 2017 16:117

    Published on: 19 September 2017

    The original article was published in Cardiovascular Diabetology 2017 16:104

  16. Original investigation

    High density lipoprotein modulates osteocalcin expression in circulating monocytes: a potential protective mechanism for cardiovascular disease in type 1 diabetes

    Cardiovascular disease (CVD) is a major cause of mortality in type 1 diabetes (T1D). A pro-calcific drift of circulating monocytes has been linked to vascular calcification and is marked by the surface express...

    Ernesto Maddaloni, Yu Xia, Kyoungmin Park, Stephanie D’Eon, Liane J. Tinsley, Ronald St-Louis, Mogher Khamaisi, Qian Li, George L. King and Hillary A. Keenan

    Cardiovascular Diabetology 2017 16:116

    Published on: 16 September 2017

  17. Original investigation

    The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control

    Good glycaemic control in type 2 diabetes (T2DM) protects the microcirculation. Current guidelines suggest glycaemic targets be relaxed in advanced diabetes. We explored whether disease duration or pre-existin...

    F. Casanova, D. D. Adingupu, F. Adams, K. M. Gooding, H. C. Looker, K. Aizawa, F. Dove, S. Elyas, J. J. F. Belch, P. E. Gates, R. C. Littleford, M. Gilchrist, H. M. Colhoun, A. C. Shore, F. Khan and W. D. Strain

    Cardiovascular Diabetology 2017 16:114

    Published on: 15 September 2017

  18. Original investigation

    Evolution and bad prognostic value of advanced glycation end products after acute heart failure: relation with body composition

    The role of advanced glycation end products (AGEs) and their soluble receptor (sRAGE) on the progression and prognosis of acute heart failure (HF) was analysed in relation with metabolic parameters as body com...

    Beatriz Paradela-Dobarro, Ángel Fernández-Trasancos, Diana Bou-Teen, Sonia Eiras, Rocío González-Ferreiro, Rosa M. Agra, Alfonso Varela-Román, Ana I. Castro-Pais, Marcos C. Carreira, Felipe F. Casanueva, Ezequiel Álvarez and José R. González-Juanatey

    Cardiovascular Diabetology 2017 16:115

    Published on: 15 September 2017

  19. Review

    Nonclinical and clinical pharmacology evidence for cardiovascular safety of saxagliptin

    In the Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus (SAVOR) trial in patients with type 2 diabetes mellitus (T2D) at high risk of cardiovascular (CV) disease, saxagli...

    Pia S. Pollack, Kristina D. Chadwick, David M. Smith, Martin Billger, Boaz Hirshberg, Nayyar Iqbal and David W. Boulton

    Cardiovascular Diabetology 2017 16:113

    Published on: 13 September 2017

  20. Original investigation

    A randomized, placebo-controlled study of the cardiovascular safety of the once-weekly DPP-4 inhibitor omarigliptin in patients with type 2 diabetes mellitus

    Omarigliptin is a once-weekly (q.w.) oral DPP-4 inhibitor that is approved for the treatment of patients with type 2 diabetes mellitus (T2DM) in Japan. To support approval of omarigliptin in the United States,...

    Ira Gantz, Menghui Chen, Shailaja Suryawanshi, Catherine Ntabadde, Sukrut Shah, Edward A. O’Neill, Samuel S. Engel, Keith D. Kaufman and Eseng Lai

    Cardiovascular Diabetology 2017 16:112

    Published on: 11 September 2017

  21. Original investigation

    Association between carotid plaque characteristics and acute cerebral infarction determined by MRI in patients with type 2 diabetes mellitus

    Type 2 diabetes mellitus (T2DM) might aggravate the carotid plaque vulnerability, and increase the risk for ischemic stroke. Few studies reported the acute stroke subtype with carotid plaque characteristics in...

    Beibei Sun, Xiao Li, Xiaosheng Liu, Xiaoqian Ge, Qing Lu, Xihai Zhao, Jun Pu, Jianrong Xu and Huilin Zhao

    Cardiovascular Diabetology 2017 16:111

    Published on: 11 September 2017

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