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  1. Content type: Original investigation

    Metabolic syndrome (MetS) is a prevalent risk factor for cardiac dysfunction. Although SGLT2-inhibitors have important cardioprotective effects in hyperglycemia, their underlying mechanisms are complex and not...

    Authors: Aysegul Durak, Yusuf Olgar, Sinan Degirmenci, Erman Akkus, Erkan Tuncay and Belma Turan

    Citation: Cardiovascular Diabetology 2018 17:144

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  2. Content type: Original investigation

    The aim of this study was to investigate the interrelationships between three bone-derived factors [serum osteocalcin (OCN), fibroblast growth factor (FGF) 23, and neutrophil gelatinase-associated lipocalin (N...

    Authors: Yiting Xu, Xiaojing Ma, Xiaoping Pan, Xingxing He, Yunfeng Xiao and Yuqian Bao

    Citation: Cardiovascular Diabetology 2018 17:143

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  3. Content type: Original investigation

    It is well known that angiopoietin-like protein 8 (ANGPTL8) exerts its effects on lipid metabolism through the inhibition of lipoprotein lipase and subsequent elevation of plasma triglyceride. However, it is n...

    Authors: Mengdie Luo, Ziyu Zhang, Yani Peng, Shuai Wang and Daoquan Peng

    Citation: Cardiovascular Diabetology 2018 17:142

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  4. Content type: Original investigation

    A strong correlation exists between type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), with CVD and the presence of atherosclerosis being the prevailing cause of morbidity and mortality in diabe...

    Authors: Lesha Pretorius, Greig J. A. Thomson, Rozanne C. M. Adams, Theo A. Nell, Willem A. Laubscher and Etheresia Pretorius

    Citation: Cardiovascular Diabetology 2018 17:141

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  5. Content type: Original investigation

    The aim of the study was to investigate whether intravenous (iv) infusion of exenatide, a synthetic GLP-1 receptor agonist, could provide a protective effect against myocardial ischemia-reperfusion injury afte...

    Authors: Guillaume Besch, Andrea Perrotti, Lucie Salomon du Mont, Marc Puyraveau, Xavier Ben-Said, Maude Baltres, Benoit Barrucand, Guillaume Flicoteaux, Lucie Vettoretti, Emmanuel Samain, Sidney Chocron and Sebastien Pili-Floury

    Citation: Cardiovascular Diabetology 2018 17:140

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  6. Content type: Original investigation

    Early detection of subclinical myocardial dysfunction in patients with diabetes mellitus (DM) is essential for recommending therapeutic interventions that can prevent or reverse heart failure, thereby improvin...

    Authors: Xi Liu, Zhi-gang Yang, Yue Gao, Lin-jun Xie, Li Jiang, Bi-yue Hu, Kai-yue Diao, Ke Shi, Hua-yan Xu, Meng-ting Shen, Yan Ren and Ying-kun Guo

    Citation: Cardiovascular Diabetology 2018 17:139

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  7. Content type: Review

    Lower-extremity arterial disease (LEAD) is a major endemic disease with an alarming increased prevalence worldwide. It is a common and severe condition with excess risk of major cardiovascular events and death...

    Authors: Mathilde Nativel, Louis Potier, Laure Alexandre, Laurence Baillet-Blanco, Eric Ducasse, Gilberto Velho, Michel Marre, Ronan Roussel, Vincent Rigalleau and Kamel Mohammedi

    Citation: Cardiovascular Diabetology 2018 17:138

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  8. Content type: Original investigation

    To evaluate clinical outcomes in patients with diabetes, treated by cardiac resynchronization therapy with a defibrillator (CRT-d), and glucagon-like peptide 1 receptor agonists (GLP-1 RA) in addition to conve...

    Authors: Celestino Sardu, Pasquale Paolisso, Cosimo Sacra, Matteo Santamaria, Claudio de Lucia, Antonio Ruocco, Ciro Mauro, Giuseppe Paolisso, Maria Rosaria Rizzo, Michelangela Barbieri and Raffaele Marfella

    Citation: Cardiovascular Diabetology 2018 17:137

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  9. Content type: Original investigation

    Little is known about the association of hyperglycemia with the development of ventricular tachycardia (VT) in patients hospitalized with acute myocardial infarction (AMI) which we examined in the present stud...

    Authors: Hoang V. Tran, Joel M. Gore, Chad E. Darling, Arlene S. Ash, Catarina I. Kiefe and Robert J. Goldberg

    Citation: Cardiovascular Diabetology 2018 17:136

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  10. Content type: Original investigation

    The aims of this study were to examine trends in the incidence and in-hospital outcomes of SAVR among T2DM patients from 2001 to 2015, to compare clinical variables among T2DM patients and matched non-T2DM pat...

    Authors: Ana López-de-Andrés, Napoleon Perez-Farinos, Javier de Miguel-Díez, Valentín Hernández-Barrera, Manuel Méndez-Bailón, José M. de Miguel-Yanes and Rodrigo Jiménez-García

    Citation: Cardiovascular Diabetology 2018 17:135

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  11. Content type: Review

    Perivascular adipose tissue (PVAT), the adipose tissue that surrounds most of the vasculature, has emerged as an active component of the blood vessel wall regulating vascular homeostasis and affecting the path...

    Authors: Xiao-Yan Qi, Shun-Lin Qu, Wen-Hao Xiong, Oren Rom, Lin Chang and Zhi-Sheng Jiang

    Citation: Cardiovascular Diabetology 2018 17:134

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  12. Content type: Original investigation

    Gestational diabetes (GDM) and milder gestational impaired glucose tolerance (GIGT) identify women at risk of developing type 2 diabetes and cardiovascular disease later in life. Accordingly, the postpartum ye...

    Authors: Sadia Mehmood, Chang Ye, Philip W. Connelly, Anthony J. Hanley, Bernard Zinman and Ravi Retnakaran

    Citation: Cardiovascular Diabetology 2018 17:133

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  13. Content type: Original investigation

    The objective of this study was to investigate the impact of sodium glucose cotransporter type 2 (SGLT2) inhibitors on left ventricular (LV) diastolic function of type 2 diabetes mellitus (T2DM) patients with ...

    Authors: Fumitaka Soga, Hidekazu Tanaka, Kazuhiro Tatsumi, Yasuhide Mochizuki, Hiroyuki Sano, Hiromi Toki, Kensuke Matsumoto, Junya Shite, Hideyuki Takaoka, Tomofumi Doi and Ken-ichi Hirata

    Citation: Cardiovascular Diabetology 2018 17:132

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  14. Content type: Original investigation

    As a strong platelet agonist on the one hand and key molecule in plasmatic coagulation on the other hand, thrombin connects primary and secondary hemostasis. Thrombin generation potential reflects the individu...

    Authors: Silvia Lee, Cihan Ay, Christoph W. Kopp, Simon Panzer and Thomas Gremmel

    Citation: Cardiovascular Diabetology 2018 17:131

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  15. Content type: Original investigation

    We used a network meta-analysis of randomized controlled trials (RCTs) to comparatively examine the effects of oral antidiabetic drugs (OADs) on left ventricular mass (LVM) in patients with type 2 diabetes.

    Authors: Satoshi Ida, Ryutaro Kaneko and Kazuya Murata

    Citation: Cardiovascular Diabetology 2018 17:129

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  16. Content type: Original investigation

    Diabetes mellitus (DM) correlates with accelerated aging and earlier appearance of geriatric phenotypes, including frailty. However, whether pre-frailty or frailty predicts greater healthcare utilization in di...

    Authors: Chia-Ter Chao, Jui Wang and Kuo-Liong Chien

    Citation: Cardiovascular Diabetology 2018 17:130

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  17. Content type: Original investigation

    Diabetes converts from a metabolic disorder into a predominantly vascular disease, once its duration extends over several years or/and when additional cardiovascular risk factors such as hypertension coexist. ...

    Authors: Dennis Kannenkeril, Agnes Bosch, Joanna Harazny, Marina Karg, Susanne Jung, Christian Ott and Roland E. Schmieder

    Citation: Cardiovascular Diabetology 2018 17:128

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  18. Content type: Original investigation

    Type 2 diabetes mellitus (T2D), rapidly increasing to epidemic proportions, globally escalates cardiovascular disease risk. Although intensive interventions and comprehensive management of environmental risks ...

    Authors: Cheng Liu, Yanfang Li, Tianwang Guan, Yanxian Lai, Yan Shen, Abudurexiti Zeyaweiding, Haiyan Zhao, Fang Li and Tutiguli Maimaiti

    Citation: Cardiovascular Diabetology 2018 17:127

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  19. Content type: Original investigation

    Ambiguity exists in relation to the role of physical activity (PA) for cardiovascular disease (CVD) risk reduction. We examined the interplay between PA dimensions and more conventional CVD risk factors to ass...

    Authors: Hanan Amadid, Nanna B. Johansen, Anne-Louise Bjerregaard, Søren Brage, Kristine Færch, Torsten Lauritzen, Daniel R. Witte, Annelli Sandbæk, Marit E. Jørgensen and Dorte Vistisen

    Citation: Cardiovascular Diabetology 2018 17:126

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  20. Content type: Original investigation

    Women with history of hypertensive disorders of pregnancy (HDP) are at increased risk of early onset cardiovascular disease and type 2 diabetes (T2D). We aimed to investigate the extent to which HDP is also as...

    Authors: Simon Timpka, Amanda Markovitz, Tommy Schyman, Ingrid Mogren, Abigail Fraser, Paul W. Franks and Janet W. Rich-Edwards

    Citation: Cardiovascular Diabetology 2018 17:124

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  21. Content type: Original investigation

    The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission.

    Authors: Kathrin Weidner, Michael Behnes, Tobias Schupp, Jonas Rusnak, Linda Reiser, Armin Bollow, Gabriel Taton, Thomas Reichelt, Dominik Ellguth, Niko Engelke, Jorge Hoppner, Ibrahim El-Battrawy, Kambis Mashayekhi, Christel Weiß, Martin Borggrefe and Ibrahim Akin

    Citation: Cardiovascular Diabetology 2018 17:125

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  22. Content type: Original investigation

    Diabetes is a leading cause of mortality and morbidity across the world. Over 50% of deaths among diabetic patients are caused by cardiovascular diseases. Cardiac diastolic dysfunction is one of the key early ...

    Authors: Beibei Dai, Huaping Li, Jiahui Fan, Yanru Zhao, Zhongwei Yin, Xiang Nie, Dao Wen Wang and Chen Chen

    Citation: Cardiovascular Diabetology 2018 17:123

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  23. Content type: Review

    The incidence and prevalence of diabetes mellitus is rapidly increasing worldwide at an alarming rate. Type 2 diabetes mellitus (T2DM) is the most prevalent form of diabetes, accounting for approximately 90–95...

    Authors: Raminderjit Kaur, Manpreet Kaur and Jatinder Singh

    Citation: Cardiovascular Diabetology 2018 17:121

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  24. Content type: Review

    For many years, cardiovascular disease (CVD) has been the leading cause of death around the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid profiles and insulin resistance. I...

    Authors: Valeska Ormazabal, Soumyalekshmi Nair, Omar Elfeky, Claudio Aguayo, Carlos Salomon and Felipe A. Zuñiga

    Citation: Cardiovascular Diabetology 2018 17:122

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  25. Content type: Original investigation

    The N-terminal prohormone of brain natriuretic peptide (NT-proBNP) is an important biomarker for the diagnosis of heart failure. Apart from this and only recently recognized, NT-proBNP levels associate with hi...

    Authors: Annette Masuch, Maik Pietzner, Martin Bahls, Kathrin Budde, Gabi Kastenmüller, Stephanie Zylla, Anna Artati, Jerzy Adamski, Henry Völzke, Marcus Dörr, Stephan B. Felix, Matthias Nauck and Nele Friedrich

    Citation: Cardiovascular Diabetology 2018 17:120

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  26. Content type: Commentary

    There is a vast disagreement in relation to the possible beneficial effects of omega-3 polyunsaturated fatty acids (omega-3 PUFA) supplementation in patients with diabetes and cardiovascular disease. The confl...

    Authors: Alexander Tenenbaum and Enrique Z. Fisman

    Citation: Cardiovascular Diabetology 2018 17:119

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  27. Content type: Original investigation

    There exist several predictive risk models for cardiovascular disease (CVD), including some developed specifically for patients with type 2 diabetes mellitus (T2DM). However, the models developed for a diabeti...

    Authors: James B. Young, Marjolaine Gauthier-Loiselle, Robert A. Bailey, Ameur M. Manceur, Patrick Lefebvre, Morris Greenberg, Marie-Hélène Lafeuille, Mei Sheng Duh, Brahim Bookhart and Carol H. Wysham

    Citation: Cardiovascular Diabetology 2018 17:118

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  28. Content type: Original investigation

    Impaired glucose metabolism is an established risk factor for coronary artery disease. Previous studies revealed that glycemic variability (GV) is also important for glucose metabolism in patients with acute c...

    Authors: Hironori Takahashi, Noriaki Iwahashi, Jin Kirigaya, Shunsuke Kataoka, Yugo Minamimoto, Masaomi Gohbara, Takeru Abe, Kozo Okada, Yasushi Matsuzawa, Masaaki Konishi, Nobuhiko Maejima, Kiyoshi Hibi, Masami Kosuge, Toshiaki Ebina, Kouichi Tamura and Kazuo Kimura

    Citation: Cardiovascular Diabetology 2018 17:116

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  29. Content type: Correction

    Unfortunately, after publication of this article [1], it was noticed that Table 1 contained errors introduced during the production process. In the WT + AT column, the FS value is 21 ± 7 and the Body Weight va...

    Authors: Maayan Waldman, Keren Cohen, Dor Yadin, Vadim Nudelman, Dan Gorfil, Michal Laniado-Schwartzman, Ran Kornwoski, Dan Aravot, Nader G. Abraham, Michael Arad and Edith Hochhauser

    Citation: Cardiovascular Diabetology 2018 17:115

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    The original article was published in Cardiovascular Diabetology 2018 17:111

  30. Content type: Original investigation

    Obesity is associated with type 2 diabetes mellitus, left ventricular diastolic dysfunction and heart failure but it is unclear to which extent it is related to left ventricular systolic dysfunction. The aim o...

    Authors: Peter Blomstrand, Peter Sjöblom, Mats Nilsson, Magnus Wijkman, Martin Engvall, Toste Länne, Fredrik H. Nyström, Carl Johan Östgren and Jan Engvall

    Citation: Cardiovascular Diabetology 2018 17:113

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  31. Content type: Original investigation

    To improve outcomes in patients with diabetes mellitus (DM) undergoing percutaneous coronary intervention remain an unmet clinical need. The study aimed to evaluate the efficacy and safety of G2-DESs and BP-DE...

    Authors: Xiao-Fang Tang, Yuan-Liang Ma, Ying Song, Jing-Jing Xu, Yi Yao, Chen He, Huan-Huan Wang, Ping Jiang, Lin Jiang, Ru Liu, Zhan Gao, Xue-yan Zhao, Shu-Bin Qiao, Yue-Jin Yang, Run-Lin Gao, Bo Xu…

    Citation: Cardiovascular Diabetology 2018 17:114

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  32. Content type: Original investigation

    Although obesity-related type 2 diabetes mellitus (T2DM) and sarcopenia in the elderly have been increasing worldwide, the associations among visceral fat accumulation, skeletal muscle indices (mass, strength,...

    Authors: Jun Murai, Hitoshi Nishizawa, Akihito Otsuka, Shiro Fukuda, Yoshimitsu Tanaka, Hirofumi Nagao, Yasuna Sakai, Masahide Suzuki, Shinji Yokota, Hidetoshi Tada, Mayumi Doi, Yuya Fujishima, Shunbun Kita, Tohru Funahashi, Norikazu Maeda, Tadashi Nakamura…

    Citation: Cardiovascular Diabetology 2018 17:112

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  33. Content type: Original investigation

    Metabolic disorders such as obesity, insulin resistance and type 2 diabetes mellitus (DM2) are all linked to diabetic cardiomyopathy that lead to heart failure. Cardiomyopathy is initially characterized by car...

    Authors: Maayan Waldman, Keren Cohen, Dor Yadin, Vadim Nudelman, Dan Gorfil, Michal Laniado-Schwartzman, Ran Kornwoski, Dan Aravot, Nader G. Abraham, Michael Arad and Edith Hochhauser

    Citation: Cardiovascular Diabetology 2018 17:111

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    The Correction to this article has been published in Cardiovascular Diabetology 2018 17:115

  34. Content type: Original investigation

    Cardiovascular disease and kidney damage are tightly associated in people with type 2 diabetes. Experimental evidence supports a causal role for vasopressin (or antidiuretic hormone) in the development of diab...

    Authors: Gilberto Velho, Stéphanie Ragot, Ray El Boustany, Pierre-Jean Saulnier, Mathilde Fraty, Kamel Mohammedi, Frédéric Fumeron, Louis Potier, Michel Marre, Samy Hadjadj and Ronan Roussel

    Citation: Cardiovascular Diabetology 2018 17:110

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  35. Content type: Original investigation

    Arterial stiffness is emerging as an independent risk factor for the development of chronic kidney disease. The sodium glucose co-transporter 2 (SGLT2) inhibitors, which lower serum glucose by inhibiting SGLT2...

    Authors: Annayya R. Aroor, Nitin A. Das, Andrea J. Carpenter, Javad Habibi, Guanghong Jia, Francisco I. Ramirez-Perez, Luis Martinez-Lemus, Camila M. Manrique-Acevedo, Melvin R. Hayden, Cornel Duta, Ravi Nistala, Eric Mayoux, Jaume Padilla, Bysani Chandrasekar and Vincent G. DeMarco

    Citation: Cardiovascular Diabetology 2018 17:108

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  36. Content type: Original investigation

    The excess risks of mortality and cardiovascular morbidity among patients with type 2 diabetes mellitus (T2DM) is well known. In this nationwide study, we assessed risks of mortality and cardiovascular events ...

    Authors: Zoltán Kiss, György Rokszin, Zsolt Abonyi-Tóth, György Jermendy, Péter Kempler, Dániel Aradi and István Wittmann

    Citation: Cardiovascular Diabetology 2018 17:107

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  37. Content type: Original investigation

    Sodium glucose co-transporter2 inhibitors reduce the incidence of cardiovascular events in patients with type 2 diabetes mellitus based on the results of recent cardiovascular outcome studies. Herein, we inves...

    Authors: Νarjes Nasiri-Ansari, Georgios K. Dimitriadis, Georgios Agrogiannis, Despoina Perrea, Ioannis D. Kostakis, Gregory Kaltsas, Athanasios G. Papavassiliou, Harpal S. Randeva and Eva Kassi

    Citation: Cardiovascular Diabetology 2018 17:106

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  38. Content type: Original investigation

    Antioxidant enzymes play a fundamental role in counteracting oxidative stress induced by high glucose. Although mitochondrial superoxide dismutase (SOD2) is the principal defence against the toxicity of supero...

    Authors: Lucia La Sala, Simona Mrakic-Sposta, Stefano Micheloni, Francesco Prattichizzo and Antonio Ceriello

    Citation: Cardiovascular Diabetology 2018 17:105

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  39. Content type: Original investigation

    Oxidative stress (OS) plays an important role in type 2 diabetes (T2D) pathogenesis and its complications. New therapies target natural antioxidants as an alternative and/or supplemental strategy to prevent an...

    Authors: Remmelt Van der Werf, Catherine Walter, William Bietiger, Elodie Seyfritz, Carole Mura, Claude Peronet, Julie Legrandois, Dalal Werner, Said Ennahar, Fabien Digel, Elisa Maillard-Pedracini, Michel Pinget, Nathalie Jeandidier, Eric Marchioni, Séverine Sigrist and Stéphanie Dal

    Citation: Cardiovascular Diabetology 2018 17:104

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  40. Content type: Original investigation

    The cardiac hormones atrial (ANP) and B-type natriuretic peptides (BNP) moderate arterial blood pressure and improve energy metabolism as well as insulin sensitivity via their shared cGMP-producing guanylyl cy...

    Authors: Sabine Tauscher, Hitoshi Nakagawa, Katharina Völker, Franziska Werner, Lisa Krebes, Tamara Potapenko, Sören Doose, Andreas L. Birkenfeld, Hideo A. Baba and Michaela Kuhn

    Citation: Cardiovascular Diabetology 2018 17:103

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  41. Content type: Original investigation

    Incretin-based therapies including dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon like peptide-1 (GLP-1) receptor agonists are novel medications for type 2 diabetes management. Several studies have fou...

    Authors: Ghadeer K. Dawwas, Steven M. Smith and Haesuk Park

    Citation: Cardiovascular Diabetology 2018 17:102

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  42. Content type: Original investigation

    Hypertriglyceridemia, insulin resistance and hyperglycemia are risk factors for atherosclerosis in type 2 diabetes. Angiopoietin-like protein 8 (ANGPTL8) is a newly identified liver-derived hormone related to ...

    Authors: Tianpeng Zheng, Bo Ge, Hongbo Liu, Bo Chen, Linyuan Qin, Liuping Xiao and Jianfei Song

    Citation: Cardiovascular Diabetology 2018 17:84

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  43. Content type: Original investigation

    The relationship between long-term glycemic variability (GV) represented by visit-to-visit HbA1c variability and baroreflex sensitivity (BRS) in type 2 diabetes mellitus (T2DM) has not been clarified by previo...

    Authors: Daisuke Matsutani, Masaya Sakamoto, Soichiro Minato, Yosuke Kayama, Norihiko Takeda, Ryuzo Horiuchi and Kazunori Utsunomiya

    Citation: Cardiovascular Diabetology 2018 17:100

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  44. Content type: Review

    Diabetes mellitus currently affects over 350 million patients worldwide and is associated with many deaths from cardiovascular complications. Sodium–glucose co-transporter 2 (SGLT-2) inhibitors are a novel cla...

    Authors: Sarayut Lahnwong, Siriporn C. Chattipakorn and Nipon Chattipakorn

    Citation: Cardiovascular Diabetology 2018 17:101

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  45. Content type: Review

    Randomized controlled trials (RCTs) suggest that supplementation with omega-3 polyunsaturated fatty acids (n-3PUFAs) may favourably modify cardiometabolic biomarkers in type 2 diabetes (T2DM). Previous meta-an...

    Authors: Lauren L. O’Mahoney, Jamie Matu, Oliver J. Price, Karen M. Birch, Ramzi A. Ajjan, Diane Farrar, Robyn Tapp, Daniel J. West, Kevin Deighton and Matthew D. Campbell

    Citation: Cardiovascular Diabetology 2018 17:98

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  46. Content type: Original investigation

    Inhibiting both type 1 and 2 sodium–glucose linked cotransporter (SGLT1/2) offers the potential to not only increase glucosuria beyond that seen with selective SGLT2 inhibition alone but to reduce glucose abso...

    Authors: Kim A. Connelly, Yanling Zhang, Jean-François Desjardins, Kerri Thai and Richard E. Gilbert

    Citation: Cardiovascular Diabetology 2018 17:99

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  47. Content type: Original investigation

    The aim of the present study was to examine the association of angiopoietin-like proteins-8 (ANGPTL8) rs2278426, cholesteryl ester-transfer protein (CETP) rs708272 and endothelial nitric oxide synthase (NOS3) rs1...

    Authors: Dalia El-Lebedy

    Citation: Cardiovascular Diabetology 2018 17:97

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  48. Content type: Original investigation

    The prognostic impact of long-term glycemic variability on clinical outcomes in patients with heart failure (HF) and type 2 diabetes mellitus (T2DM) remains unclear. We determined and compared hemoglobin A1c (...

    Authors: Jun Gu, Jian-an Pan, Yu-qi Fan, Hui-li Zhang, Jun-feng Zhang and Chang-qian Wang

    Citation: Cardiovascular Diabetology 2018 17:96

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