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  1. Adults who have experienced multiple cardiovascular disease (CVD) events have a very high risk for additional events. Diabetes and chronic kidney disease (CKD) are each associated with an increased risk for re...

    Authors: Demetria Hubbard, Lisandro D. Colantonio, Robert S. Rosenson, Todd M. Brown, Elizabeth A. Jackson, Lei Huang, Kate K. Orroth, Stephanie Reading, Mark Woodward, Vera Bittner, Orlando M. Gutierrez, Monika M. Safford, Michael E. Farkouh and Paul Muntner

    Citation: Cardiovascular Diabetology 2021 20:58

    Content type: Original investigation

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  2. Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that has demonstrated cardiovascular and renal protection in patients with type 2 diabetes (T2D). We hypothesized that empaglifozin (EMPA) co...

    Authors: B. Gaborit, P. Ancel, A. E. Abdullah, F. Maurice, I. Abdesselam, A. Calen, A. Soghomonian, M. Houssays, I. Varlet, M. Eisinger, A. Lasbleiz, F. Peiretti, C. E. Bornet, Y. Lefur, L. Pini, S. Rapacchi…

    Citation: Cardiovascular Diabetology 2021 20:57

    Content type: Original investigation

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  3. Impaired fasting glucose (IFG) is a prevalent and potentially reversible intermediate stage leading to type 2 diabetes that increases risk for cardiometabolic complications. The identification of clinical and ...

    Authors: Magdalena del Rocío Sevilla-González, Jordi Merino, Hortensia Moreno-Macias, Rosalba Rojas-Martínez, Donají Verónica Gómez-Velasco and Alisa K. Manning

    Citation: Cardiovascular Diabetology 2021 20:56

    Content type: Original investigation

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  4. The epidemic of diabetes mellitus (DM) necessitates the development of novel therapeutic and preventative strategies to attenuate complications of this debilitating disease. Diabetic cardiomyopathy (DCM) is a ...

    Authors: Daniel Jakubik, Alex Fitas, Ceren Eyileten, Joanna Jarosz-Popek, Anna Nowak, Pamela Czajka, Zofia Wicik, Harald Sourij, Jolanta M. Siller-Matula, Salvatore De Rosa and Marek Postula

    Citation: Cardiovascular Diabetology 2021 20:55

    Content type: Review

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  5. The prognostic importance of non-traditional risk factors for peripheral artery disease (PAD) development/progression is scarcely studied in diabetes. We investigated if carotid intima-media thickness (CIMT) a...

    Authors: Claudia R. L. Cardoso, Juliana V. Melo, Thainá R. M. Santos, Nathalie C. Leite and Gil F. Salles

    Citation: Cardiovascular Diabetology 2021 20:54

    Content type: Original investigation

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  6. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Judith van Haare, M. Eline Kooi, Jurgen W. G. E. van Teeffelen, Hans Vink, Jos Slenter, Hanneke Cobelens, Gustav J. Strijkers, Dennis Koehn, Mark J. Post and Marc van Bilsen

    Citation: Cardiovascular Diabetology 2021 20:53

    Content type: Correction

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    The original article was published in Cardiovascular Diabetology 2017 16:47

  7. Diabetes increases a patient’s risk of developing atrial fibrillation by 49%. Patients with nonvalvular atrial fibrillation are at a fivefold increased risk of stroke and die more frequently from vascular caus...

    Authors: Craig I. Coleman, Olivia S. Costa, Christopher W. Brescia, Burcu Vardar, Khaled Abdelgawwad and Nitesh Sood

    Citation: Cardiovascular Diabetology 2021 20:52

    Content type: Original investigation

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  8. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Judith van Haare, M. Eline Kooi, Hans Vink, Mark J. Post, Jurgen W. G. E. van Teeffelen, Jos Slenter, Chantal Munts, Hanneke Cobelens, Gustav J. Strijkers, Dennis Koehn and Marc van Bilsen

    Citation: Cardiovascular Diabetology 2021 20:51

    Content type: Correction

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    The original article was published in Cardiovascular Diabetology 2015 14:150

  9. Acetylcholine (ACh) plays a crucial role in the function of the heart. Recent evidence suggests that cardiomyocytes possess a non-neuronal cholinergic system (NNCS) that comprises of choline acetyltransferase ...

    Authors: Eng Leng Saw, James T. Pearson, Daryl O. Schwenke, Pujika Emani Munasinghe, Hirotsugu Tsuchimochi, Shruti Rawal, Sean Coffey, Philip Davis, Richard Bunton, Isabelle Van Hout, Yuko Kai, Michael J. A. Williams, Yoshihiko Kakinuma, Martin Fronius and Rajesh Katare

    Citation: Cardiovascular Diabetology 2021 20:50

    Content type: Original investigation

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  10. Soluble suppression of tumorigenesis-2 (sST2) is implicated in myocardial overload and has long been recognized as an inflammatory marker related to heart failure and acute coronary syndrome, but data on the p...

    Authors: Man Li, Lei Duan, Yulun Cai, Benchuan Hao, Jianqiao Chen, Huiying Li and Hongbin Liu

    Citation: Cardiovascular Diabetology 2021 20:49

    Content type: Original investigation

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  11. Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome, with several underlying etiologic and pathophysiologic factors. The presence of diabetes might identify an important phenotyp...

    Authors: Sibille Lejeune, Clotilde Roy, Alisson Slimani, Agnès Pasquet, David Vancraeynest, Jean-Louis Vanoverschelde, Bernhard L. Gerber, Christophe Beauloye and Anne-Catherine Pouleur

    Citation: Cardiovascular Diabetology 2021 20:48

    Content type: Original investigation

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  12. Patients with type 2 diabetes mellitus (T2DM) are at high risk of cardiovascular mortality, but the mechanisms behind this remain unclear. Prothrombotic fibrin clot properties have been shown in T2DM and cardi...

    Authors: Agata Hanna Bryk, Małgorzata Konieczyńska, Maciej Polak, Dariusz Plicner, Maciej Bochenek and Anetta Undas

    Citation: Cardiovascular Diabetology 2021 20:47

    Content type: Original investigation

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  13. Triglyceride-glucose (TyG) index was recently suggested to be a reliable surrogate marker of insulin resistance. We aim to investigate the associations between baseline and long-term TyG index with subsequent ...

    Authors: Anxin Wang, Guangyao Wang, Qian Liu, Yingting Zuo, Shuohua Chen, Boni Tao, Xue Tian, Penglian Wang, Xia Meng, Shouling Wu, Yongjun Wang and Yilong Wang

    Citation: Cardiovascular Diabetology 2021 20:46

    Content type: Original investigation

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  15. Endothelial progenitor cells (EPCs) has been shown to be dysfunctional in both type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) leading to poor regeneration of endothelium and renal perfusion. ...

    Authors: Seshagiri Rao Nandula, Nabanita Kundu, Hassan B. Awal, Beda Brichacek, Mona Fakhri, Nikhila Aimalla, Adrian Elzarki, Richard L. Amdur and Sabyasachi Sen

    Citation: Cardiovascular Diabetology 2021 20:44

    Content type: Original investigation

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  16. Triglyceride glucose (TyG) index is considered a reliable alternative marker of insulin resistance and an independent predictor of cardiovascular (CV) outcomes. However, the prognostic value of TyG index in pa...

    Authors: Yue Zhang, Xiaosong Ding, Bing Hua, Qingbo Liu, Hui Gao, Hui Chen, Xue-Qiao Zhao, Weiping Li and Hongwei Li

    Citation: Cardiovascular Diabetology 2021 20:43

    Content type: Original investigation

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  18. Clinical trials are often performed to investigate the effects of various types of cardiometabolic therapies on cardiovascular surrogate markers, including vascular function and biomarkers. This study platform...

    Authors: Atsushi Tanaka and Koichi Node

    Citation: Cardiovascular Diabetology 2021 20:41

    Content type: Commentary

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  19. There are limited data on the association of diabetes mellitus (DM) and levels of glycated hemoglobin (HbA1c) with outcomes in patients with atrial fibrillation (AF).

    Authors: Andreas S. Papazoglou, Anastasios Kartas, Athanasios Samaras, Ioannis Vouloagkas, Eleni Vrana, Dimitrios V. Moysidis, Evangelos Akrivos, Georgios Kotzampasis, Amalia Baroutidou, Anastasios Papanastasiou, Evangelos Liampas, Michail Botis, Efstratios Karagiannidis, Nikolaos Stalikas, Haralambos Karvounis, Apostolos Tzikas…

    Citation: Cardiovascular Diabetology 2021 20:40

    Content type: Original investigation

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  20. Sodium glucose cotransporter-2 inhibitors (SGLT2i) reduce the risk of heart failure and new data show they can prevent atrial fibrillation (AF). We examined the association between SGLT2i and AF in the Food an...

    Authors: Benedetta Maria Bonora, Emanuel Raschi, Angelo Avogaro and Gian Paolo Fadini

    Citation: Cardiovascular Diabetology 2021 20:39

    Content type: Original investigation

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  21. Gender disparities in the management of dysglycaemia, defined as either impaired glucose tolerance (IGT) or type 2 diabetes (T2DM), in coronary artery disease (CAD) patients are a medical challenge. Recent dat...

    Authors: Giulia Ferrannini, Dirk De Bacquer, Pieter Vynckier, Guy De Backer, Viveca Gyberg, Kornelia Kotseva, Linda Mellbin, Anna Norhammar, Jaakko Tuomilehto, David Wood and Lars Rydén

    Citation: Cardiovascular Diabetology 2021 20:38

    Content type: Original investigation

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  22. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Shaminie J. Athinarayanan, Sarah J. Hallberg, Amy L. McKenzie, Katharina Lechner, Sarah King, James P. McCarter, Jeff S. Volek, Stephen D. Phinney and Ronald M. Krauss

    Citation: Cardiovascular Diabetology 2021 20:37

    Content type: Correction

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    The original article was published in Cardiovascular Diabetology 2020 19:208

  23. In this commentary, we introduce the concepts of removed and residual risks in conditioning thecardiorenal outlook of patients with type 2 diabetes (T2D). The removed cardiorenal risk represents the risk of pr...

    Authors: Dario Giugliano, Maria Ida Maiorino, Giuseppe Bellastella and Katherine Esposito

    Citation: Cardiovascular Diabetology 2021 20:36

    Content type: Commentary

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  24. Epicardial adipose tissue (EAT) has anatomic and functional proximity to the heart and is considered a novel diagnostic marker and therapeutic target in cardiometabolic diseases. The aim of this study was to e...

    Authors: Emmanuel Cosson, Minh Tuan Nguyen, Imen Rezgani, Sopio Tatulashvili, Meriem Sal, Narimane Berkane, Lucie Allard, Pierre-Yves Brillet and Hélène Bihan

    Citation: Cardiovascular Diabetology 2021 20:35

    Content type: Original investigation

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  25. Recently, the European Society of Cardiology (ESC) and European Association for the Society of Diabetes (EASD) introduced a new cardiovascular disease (CVD) risk stratification model to aid further treatment d...

    Authors: Suriya Prausmüller, Michael Resl, Henrike Arfsten, Georg Spinka, Raphael Wurm, Stephanie Neuhold, Philipp E. Bartko, Georg Goliasch, Guido Strunk, Noemi Pavo, Martin Clodi and Martin Hülsmann

    Citation: Cardiovascular Diabetology 2021 20:34

    Content type: Original investigation

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  26. Hyperglycemia has been associated with increased inflammatory indexes and larger infarct sizes in patients with obstructive acute myocardial infarction (obs-AMI). In contrast, no studies have explored these co...

    Authors: Pasquale Paolisso, Alberto Foà, Luca Bergamaschi, Francesco Donati, Michele Fabrizio, Chiara Chiti, Francesco Angeli, Sebastiano Toniolo, Andrea Stefanizzi, Matteo Armillotta, Paola Rucci, Gianmarco Iannopollo, Gianni Casella, Cinzia Marrozzini, Nazzareno Galiè and Carmine Pizzi

    Citation: Cardiovascular Diabetology 2021 20:33

    Content type: Original investigation

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  27. While the cardioprotective benefits of sodium-glucose cotransporter-2 (SGLT2) inhibitors have been established in patients with cardiovascular disease (CVD), their advantages over other anti-diabetic drugs at ...

    Authors: Shigenori Hiruma, Fumika Shigiyama, Shinji Hisatake, Sunao Mizumura, Nobuyuki Shiraga, Masaaki Hori, Takanori Ikeda, Takahisa Hirose and Naoki Kumashiro

    Citation: Cardiovascular Diabetology 2021 20:32

    Content type: Original investigation

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  28. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Lei Guo, Junjie Wang, Huaiyu Ding, Shaoke Meng, Xiaoyan Zhang, Haichen Lv, Lei Zhong, Jian Wu, Jiaying Xu, Xuchen Zhou and Rongchong Huang

    Citation: Cardiovascular Diabetology 2021 20:31

    Content type: Correction

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    The original article was published in Cardiovascular Diabetology 2020 19:100

  29. Metformin is a first-line drug in type 2 diabetes mellitus (T2DM) treatment, yet whether metformin may increase all-cause or cardiovascular mortality of T2DM patients remains inconclusive.

    Authors: Tian Li, Rui Providencia, Nan Mu, Yue Yin, Mai Chen, Yishi Wang, Manling Liu, Lu Yu, Chunhu Gu and Heng Ma

    Citation: Cardiovascular Diabetology 2021 20:30

    Content type: Original investigation

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  30. Diabetes mellitus (DM) is highly prevalent among patients undergoing percutaneous coronary intervention (PCI) for chronic total occlusion (CTO). Therefore, the purpose of our study was to investigate the clini...

    Authors: Yong Zhu, Shuai Meng, Maolin Chen, Kesen Liu, Ruofei Jia, Hong Li, Huagang Zhu and Zening Jin

    Citation: Cardiovascular Diabetology 2021 20:29

    Content type: Original investigation

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  31. Atherogenic dyslipidaemia has been implicated in the residual risk for cardiovascular morbidity and mortality, which remains despite attainment of LDL cholesterol goals especially in individuals with type 2 di...

    Authors: Emanuela Orsi, Giuseppe Penno, Anna Solini, Enzo Bonora, Cecilia Fondelli, Roberto Trevisan, Monica Vedovato, Franco Cavalot, Susanna Morano, Marco G. Baroni, Antonio Nicolucci and Giuseppe Pugliese

    Citation: Cardiovascular Diabetology 2021 20:28

    Content type: Original investigation

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  32. We sought to evaluate the association of metabolic syndrome (MetS) and computed tomography (CT)-derived cardiometabolic biomarkers (non-alcoholic fatty liver disease [NAFLD] and epicardial adipose tissue [EAT]...

    Authors: Andrew Lin, Nathan D. Wong, Aryabod Razipour, Priscilla A. McElhinney, Frederic Commandeur, Sebastien J. Cadet, Heidi Gransar, Xi Chen, Stephanie Cantu, Robert J. H. Miller, Nitesh Nerlekar, Dennis T. L. Wong, Piotr J. Slomka, Alan Rozanski, Balaji K. Tamarappoo, Daniel S. Berman…

    Citation: Cardiovascular Diabetology 2021 20:27

    Content type: Original investigation

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  33. The independent role of pericardial adipose tissue (PAT) as an ectopic fat associated with cardiovascular disease (CVD) remains controversial. This study aimed to determine whether PAT is associated with left ...

    Authors: Jin-Seok Kim, Seon Won Kim, Jong Seok Lee, Seung Ku Lee, Robert Abbott, Ki Yeol Lee, Hong Euy Lim, Ki-Chul Sung, Goo-Yeong Cho, Kwang Kon Koh, Sun H. Kim, Chol Shin and Seong Hwan Kim

    Citation: Cardiovascular Diabetology 2021 20:26

    Content type: Original investigation

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  34. Although the benefits of sodium–glucose cotransporter 2 inhibitors (SGLT2i) on cardiovascular events have been reported in patients with type 2 diabetes mellitus (T2DM) with or without heart failure (HF), the ...

    Authors: Yi-Wen Yu, Xue-Mei Zhao, Yun-Hong Wang, Qiong Zhou, Yan Huang, Mei Zhai and Jian Zhang

    Citation: Cardiovascular Diabetology 2021 20:25

    Content type: Review

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  35. There remain uncertainties regarding diabetes mellitus and the incidence of atrial fibrillation (AF), in relation to type of diabetes, and the interactions with sex and age. We investigated whether diabetes co...

    Authors: Arnaud Bisson, Alexandre Bodin, Grégoire Fauchier, Julien Herbert, Denis Angoulvant, Pierre Henri Ducluzeau, Gregory Y. H. Lip and Laurent Fauchier

    Citation: Cardiovascular Diabetology 2021 20:24

    Content type: Original investigation

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  36. Diabetes patients without obstructive coronary artery disease as assessed by coronary angiography have a low risk of myocardial infarction, but their myocardial infarction risk may still be higher than the gen...

    Authors: Kevin Kris Warnakula Olesen, Morten Madsen, Christine Gyldenkerne, Pernille Gro Thrane, Troels Thim, Lisette Okkels Jensen, Hans Erik Bøtker, Henrik Toft Sørensen and Michael Maeng

    Citation: Cardiovascular Diabetology 2021 20:23

    Content type: Original investigation

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  37. Insulin resistance carries increased risk of heart failure, although the pathophysiological mechanisms remain unclear. LV global longitudinal strain (LVGLS) assessed by speckle-tracking echocardiography has em...

    Authors: Kazutoshi Hirose, Koki Nakanishi, Masao Daimon, Naoko Sawada, Yuriko Yoshida, Kentaro Iwama, Yuko Yamamoto, Jumpei Ishiwata, Megumi Hirokawa, Katsuhiro Koyama, Tomoko Nakao, Hiroyuki Morita, Marco R. Di Tullio, Shunichi Homma and Issei Komuro

    Citation: Cardiovascular Diabetology 2021 20:22

    Content type: Original investigation

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  38. To conduct a real-word-study-based cost-effectiveness analysis of a GLP-1 receptor agonist (GLP-1RA) versus insulin among type 2 diabetes patients requiring intensified injection therapy and a systematic revie...

    Authors: Chen-Yi Yang, Ying-Ren Chen, Huang-Tz Ou and Shihchen Kuo

    Citation: Cardiovascular Diabetology 2021 20:21

    Content type: Original investigation

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  39. The metabolic syndrome (MetS) and its components are associated with the development of atrial fibrillation (AF). However, the impact of time-burden of MetS on the risk of AF is unknown. We investigated the ef...

    Authors: Hyo-Jeong Ahn, Kyung-Do Han, Eue-Keun Choi, Jin-Hyung Jung, Soonil Kwon, So-Ryoung Lee, Seil Oh and Gregory Y. H. Lip

    Citation: Cardiovascular Diabetology 2021 20:20

    Content type: Original investigation

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  40. The triglyceride–glucose (TyG) index, which is a simple surrogate marker of insulin resistance, has been suggested as a contributor of cardiovascular disease. However, evidence on the effect of long-term eleva...

    Authors: Xue Tian, Yingting Zuo, Shuohua Chen, Qian Liu, Boni Tao, Shouling Wu and Anxin Wang

    Citation: Cardiovascular Diabetology 2021 20:19

    Content type: Original investigation

    Published on:

  41. Mortality in individuals with diabetes with severe hypoglycemia requiring ambulance services intervention is high and it is unclear whether this is modifiable. Our aim was to characterise this high-risk group ...

    Authors: Sam M. Pearson, Beverley Whittam, Kavita Kulavarasalingam, Amelia Mitchell-Gears, Cathyrn James and Ramzi A. Ajjan

    Citation: Cardiovascular Diabetology 2021 20:18

    Content type: Original investigation

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  42. Hospitalization for major diabetes complications, including myocardial infarction, stroke, lower-extremity amputation, and end-stage kidney disease, is on the rise and represents a great health burden for pati...

    Authors: Dario Giugliano, Miriam Longo, Lorenzo Scappaticcio, Paola Caruso and Katherine Esposito

    Citation: Cardiovascular Diabetology 2021 20:17

    Content type: Review

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  43. Patients with diabetes and triple-vessel disease (TVD) are associated with a high risk of events. The choice of treatment strategies remains a subject of discussion. In the real-world, we aim to compare the ou...

    Authors: Xueyan Zhao, Lianjun Xu, Lin Jiang, Jian Tian, Yin Zhang, Dong Wang, Kai Sun, Bo Xu, Wei Zhao, Rutai Hui, Runlin Gao, Lei Song and Jinqing Yuan

    Citation: Cardiovascular Diabetology 2021 20:16

    Content type: Original investigation

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  44. Previous studies have suggested that high mean glucose levels and glycemic abnormalities such as glucose fluctuation and hypoglycemia accelerate the progression of atherosclerosis in patients with type 2 diabe...

    Authors: Satomi Wakasugi, Tomoya Mita, Naoto Katakami, Yosuke Okada, Hidenori Yoshii, Takeshi Osonoi, Nobuichi Kuribayashi, Yoshinobu Taneda, Yuichi Kojima, Masahiko Gosho, Iichiro Shimomura and Hirotaka Watada

    Citation: Cardiovascular Diabetology 2021 20:15

    Content type: Original investigation

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  45. Patients with diabetes and acute coronary syndrome (ACS) are at high risk for subsequent heart failure. Apabetalone is a selective inhibitor of bromodomain and extra-terminal (BET) proteins, epigenetic regulat...

    Authors: Stephen J. Nicholls, Gregory G. Schwartz, Kevin A. Buhr, Henry N. Ginsberg, Jan O. Johansson, Kamyar Kalantar-Zadeh, Ewelina Kulikowski, Peter P. Toth, Norman Wong, Michael Sweeney and Kausik K. Ray

    Citation: Cardiovascular Diabetology 2021 20:13

    Content type: Original investigation

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  46. Diastolic dysfunction is highly prevalent in patients with type 2 diabetes mellitus (T2DM) and is associated with overweight, glucose dysregulation and coronary artery disease (CAD). The GLP-1 receptor agonist...

    Authors: Preman Kumarathurai, Ahmad Sajadieh, Christian Anholm, Ole P. Kristiansen, Steen B. Haugaard and Olav W. Nielsen

    Citation: Cardiovascular Diabetology 2021 20:12

    Content type: Original investigation

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  47. Patients with type 2 diabetes mellitus (T2DM) are susceptible to coexisted with chronic kidney disease (CKD), which may increase cardiovascular mortality in these patients. The present study aimed to verify wh...

    Authors: Yi Zhang, Jin Wang, Yan Ren, Wei-feng Yan, Li Jiang, Yuan Li and Zhi-gang Yang

    Citation: Cardiovascular Diabetology 2021 20:11

    Content type: Original investigation

    Published on:

  49. Sodium–glucose linked transporter type 2 (SGLT-2) inhibition has been shown to reduce cardiovascular mortality in heart failure independently of glycemic control and prevents the onset of atrial arrhythmias, a...

    Authors: David Bode, Lukas Semmler, Paulina Wakula, Niklas Hegemann, Uwe Primessnig, Nicola Beindorff, David Powell, Raphael Dahmen, Hartmut Ruetten, Christian Oeing, Alessio Alogna, Daniel Messroghli, Burkert M. Pieske, Frank R. Heinzel and Felix Hohendanner

    Citation: Cardiovascular Diabetology 2021 20:7

    Content type: Original investigation

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  50. In the EMPA-REG OUTCOME trial (Empagliflozin Cardiovascular Outcome Event Trial) treatment with the sodium-glucose cotransporter-2 (SGLT2) inhibitor empagliflozin significantly reduced heart failure hospitaliz...

    Authors: Matthias Rau, Kirsten Thiele, Niels-Ulrik Korbinian Hartmann, Alexander Schuh, Ertunc Altiok, Julia Möllmann, András P. Keszei, Michael Böhm, Nikolaus Marx and Michael Lehrke

    Citation: Cardiovascular Diabetology 2021 20:6

    Content type: Original investigation

    Published on:

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ISSN: 1475-2840