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  1. Diabetes has strongly been linked to atrial fibrillation, ischaemic heart disease and heart failure. The epidemiology of these cardiovascular diseases is changing, however, due to changes in prevalence of obes...

    Authors: Amy Groenewegen, Victor W. Zwartkruis, Betül Cekic, Rudolf. A. de Boer, Michiel Rienstra, Arno W. Hoes, Frans H. Rutten and Monika Hollander

    Citation: Cardiovascular Diabetology 2021 20:123

    Content type: Original investigation

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  2. Disturbances of glucose metabolism can be diagnosed by an oral glucose tolerance test (OGTT) and by glycated haemoglobin (HbA1c). The aim of this study was to investigate the association between newly detected...

    Authors: Stelios Karayiannides, Catarina Djupsjö, Jeanette Kuhl, Claes Hofman-Bang, Anna Norhammar, Martin J. Holzmann and Pia Lundman

    Citation: Cardiovascular Diabetology 2021 20:122

    Content type: Original investigation

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  3. Cardiac remodeling is one of the major risk factors for heart failure. In patients with type 2 diabetes, sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of the first hospitalization for heart...

    Authors: Yuze Zhang, Xiaoyan Lin, Yong Chu, Xiaoming Chen, Heng Du, Hailin Zhang, Changsheng Xu, Hong Xie, Qinyun Ruan, Jinxiu Lin, Jie Liu, Jinzhang Zeng, Ke Ma and Dajun Chai

    Citation: Cardiovascular Diabetology 2021 20:121

    Content type: Original investigation

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  6. Information about the renin–angiotensin–aldosterone system (RAAS) in obese individuals before and after bariatric surgery is scarce. Aim of this study was to analyze the RAAS in severely obese subjects, in rel...

    Authors: Lucia La Sala, Elena Tagliabue, Elaine Vieira, Antonio E Pontiroli and Franco Folli

    Citation: Cardiovascular Diabetology 2021 20:118

    Content type: Original investigation

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  8. Diabetes is associated with a significantly elevated risk of cardiovascular disease and its specific pathophysiology remains unclear. Recent studies have changed our understanding of cardiac cellularity, with ...

    Authors: Charles D. Cohen, Miles J. De Blasio, Man K. S. Lee, Gabriella E. Farrugia, Darnel Prakoso, Crisdion Krstevski, Minh Deo, Daniel G. Donner, Helen Kiriazis, Michelle C. Flynn, Taylah L. Gaynor, Andrew J. Murphy, Grant R. Drummond, Alexander R. Pinto and Rebecca H. Ritchie

    Citation: Cardiovascular Diabetology 2021 20:116

    Content type: Original investigation

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  9. Prior studies in animal models showed that increased cardiac expression of TRIB3 has a pathogenic role in inducing left ventricular mass (LVM). Whether alterations in TRIB3 expression or function have a pathog...

    Authors: Gaia Chiara Mannino, Carolina Averta, Teresa Vanessa Fiorentino, Elena Succurro, Rosangela Spiga, Elettra Mancuso, Sofia Miceli, Maria Perticone, Angela Sciacqua, Francesco Andreozzi and Giorgio Sesti

    Citation: Cardiovascular Diabetology 2021 20:115

    Content type: Original investigation

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  10. Carotid atherosclerosis represents one of the complications of diabetes mellitus. In particular, plaque instability contributes to disease progression and stroke incidence. High mobility group box-1 (HMGB1) is...

    Authors: Federico Biscetti, Giovanni Tinelli, Maria Margherita Rando, Elisabetta Nardella, Andrea Leonardo Cecchini, Flavia Angelini, Giuseppe Straface, Marco Filipponi, Vincenzo Arena, Dario Pitocco, Antonio Gasbarrini, Massimo Massetti and Andrea Flex

    Citation: Cardiovascular Diabetology 2021 20:114

    Content type: Original investigation

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  11. Previous studies has shown a significant relationship between baseline triglyceride-glucose (TyG) index and subsequent cardiovascular disease (CVD). However, the effect of longitudinal changes in TyG index on ...

    Authors: Anxin Wang, Xue Tian, Yingting Zuo, Shuohua Chen, Xia Meng, Shouling Wu and Yongjun Wang

    Citation: Cardiovascular Diabetology 2021 20:113

    Content type: Original investigation

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  12. In a recently published paper in Cardiovascular Diabetology, Sinha et al. (Association of fasting glucose with lifetime risk of incident heart failure: the Lifetime Risk Pooling Project. Cardiovasc Diabetol. 2021...

    Authors: Jian-di Wu, Dong-liang Liang and Yue Xie

    Citation: Cardiovascular Diabetology 2021 20:112

    Content type: Commentary

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  13. The metabolic syndrome (MetS), defined by the simultaneous clustering of cardio-metabolic risk factors, is a significant worldwide public health burden with an estimated 25% prevalence worldwide. The pathogene...

    Authors: Mohamed A. Elhadad, Rory Wilson, Shaza B. Zaghlool, Cornelia Huth, Christian Gieger, Harald Grallert, Johannes Graumann, Wolfgang Rathmann, Wolfgang Koenig, Moritz F. Sinner, Kristian Hveem, Karsten Suhre, Barbara Thorand, Christian Jonasson, Melanie Waldenberger and Annette Peters

    Citation: Cardiovascular Diabetology 2021 20:111

    Content type: Original investigation

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  14. Since 1985, the thiazolidinedione pioglitazone has been widely used as an insulin sensitizer drug for type 2 diabetes mellitus (T2DM). Although fluid retention was early recognized as a safety concern, data fr...

    Authors: Lorenzo Nesti, Domenico Tricò, Alessandro Mengozzi and Andrea Natali

    Citation: Cardiovascular Diabetology 2021 20:109

    Content type: Review

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  15. Diabetes mellitus (DM) and depression are bidirectionally interrelated. We recently identified long-term trajectories of depression symptom severity in individuals with coronary heart disease (CHD), which were...

    Authors: Raphael S. Peter, Andrea Jaensch, Ute Mons, Ben Schöttker, Roman Schmucker, Wolfgang Koenig, Hermann Brenner and Dietrich Rothenbacher

    Citation: Cardiovascular Diabetology 2021 20:108

    Content type: Original investigation

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  16. In a recent meta-analysis of randomized controlled trials of sodium glucose co-transporter 2 inhibitors (SGLT2i) in patients with diabetes, Lin and colleagues showed a positive association between SGLT2i-induc...

    Authors: Louis Potier, Kamel Mohammedi, Gilberto Velho and Ronan Roussel

    Citation: Cardiovascular Diabetology 2021 20:107

    Content type: Commentary

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  17. Type 2 diabetes mellitus (DM) is one of the most common comorbidities among patients with heart failure (HF) with reduced ejection fraction (HFrEF). There are limited data regarding efficacy of hybrid comprehe...

    Authors: Renata Główczyńska, Ewa Piotrowicz, Dominika Szalewska, Ryszard Piotrowicz, Ilona Kowalik, Michael J. Pencina, Wojciech Zaręba, Maciej Banach, Piotr Orzechowski, Sławomir Pluta, Robert Irzmański, Zbigniew Kalarus and Grzegorz Opolski

    Citation: Cardiovascular Diabetology 2021 20:106

    Content type: Original investigation

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  18. Metabolic syndrome (MetS) is an independent risk factor for the incidence of cardiovascular diseases. We investigated whether or to what extent MetS and its components was associated with coronary collateraliz...

    Authors: Tong Liu, Zheng Wu, Jinghua Liu, Yun Lv and Wenzheng Li

    Citation: Cardiovascular Diabetology 2021 20:104

    Content type: Original investigation

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  19. Transferring results obtained in cardiovascular outcome trials (CVOTs) to the real-world setting is challenging. We herein transposed CVOT results to the population of patients with type 2 diabetes (T2D) seen ...

    Authors: V. Sciannameo, P. Berchialla, A. Avogaro and G. P. Fadini

    Citation: Cardiovascular Diabetology 2021 20:103

    Content type: Original investigation

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  20. Women with type 2 diabetes are disproportionally affected by macrovascular complications; we here investigated whether this is also the case for microvascular complications and retinal microvascular measures.

    Authors: Rianneke de Ritter, Simone J. S. Sep, Carla J. H. van der Kallen, Marleen M. J. van Greevenbroek, Marit de Jong, Rimke C. Vos, Michiel L. Bots, Jos P. H. Reulen, Alfons J. H. M. Houben, Carroll A. B. Webers, Tos T. J. M. Berendschot, Pieter C. Dagnelie, Simone J. P. M. Eussen, Miranda T. Schram, Annemarie Koster, Sanne A. E. Peters…

    Citation: Cardiovascular Diabetology 2021 20:102

    Content type: Original investigation

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  21. Several studies suggest that, together with glucose variability, the variability of other risk factors, as blood pressure, plasma lipids, heart rate, body weight, and serum uric acid, might play a role in the ...

    Authors: Antonio Ceriello and Francesco Prattichizzo

    Citation: Cardiovascular Diabetology 2021 20:101

    Content type: Review

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  22. Cardiac arrhythmias are associated with poorer outcomes in patients with heart failure (HF), diabetes mellitus (DM), and chronic kidney disease (CKD). Previous studies have shown inconsistent conclusions regar...

    Authors: Hang-Long Li, Gregory-Y. H. Lip, Qi Feng, Yue Fei, Yi-Kei Tse, Mei-zhen Wu, Qing-wen Ren, Hung-Fat Tse, Bernard-M. Y. Cheung and Kai-Hang Yiu

    Citation: Cardiovascular Diabetology 2021 20:100

    Content type: Original investigation

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  23. About 50% of hospitalized coronavirus disease 2019 (COVID-19) patients with diabetes mellitus (DM) developed myocardial damage. The mechanisms of direct SARS-CoV-2 cardiomyocyte infection include viral invasio...

    Authors: Nunzia D’Onofrio, Lucia Scisciola, Celestino Sardu, Maria Consiglia Trotta, Marisa De Feo, Ciro Maiello, Pasquale Mascolo, Francesco De Micco, Fabrizio Turriziani, Emilia Municinò, Pasquale Monetti, Antonio Lombardi, Maria Gaetana Napolitano, Federica Zito Marino, Andrea Ronchi, Vincenzo Grimaldi…

    Citation: Cardiovascular Diabetology 2021 20:99

    Content type: Original investigation

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  24. Metabolic syndrome certainly favors growth of carotid plaque; however, it is uncertain if it determines plaque destabilization. Furthermore, it is likely that only some components of metabolic syndrome are ass...

    Authors: Francesca Servadei, Lucia Anemona, Marina Cardellini, Manuel Scimeca, Manuela Montanaro, Valentina Rovella, Francesca Di Daniele, Erica Giacobbi, Iacopo Maria Legramante, Annalisa Noce, Rita Bonfiglio, Patrizia Borboni, Nicola Di Daniele, Arnaldo Ippoliti, Massimo Federici and Alessandro Mauriello

    Citation: Cardiovascular Diabetology 2021 20:98

    Content type: Original investigation

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  25. Type 2 Diabetes is a major risk factor for cardiovascular (CV) mortality. Insulin resistance can be evaluated non-invasively by insulin sensitivity indices (ISI) such as the Mcauley index (MCAi), which is a fu...

    Authors: Yonatan Moshkovits, David Rott, Angela Chetrit and Rachel Dankner

    Citation: Cardiovascular Diabetology 2021 20:97

    Content type: Original investigation

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  26. Increased risk of cardiovascular events is associated not only with dyslipidemias, but also with abnormalities in glucose metabolism and liver function. This study uses pooled analysis to explore the in-depth ...

    Authors: Koutaro Yokote, Shizuya Yamashita, Hidenori Arai, Eiichi Araki, Mitsunori Matsushita, Toshiaki Nojima, Hideki Suganami and Shun Ishibashi

    Citation: Cardiovascular Diabetology 2021 20:96

    Content type: Original investigation

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  27. The association between glucose variability and the progression of atherosclerosis is not completely understood. We aimed to evaluate the associations of glucose variability with the progression of atheroscler...

    Authors: Naohiro Taya, Naoto Katakami, Tomoya Mita, Yosuke Okada, Satomi Wakasugi, Hidenori Yoshii, Toshihiko Shiraiwa, Akihito Otsuka, Yutaka Umayahara, Kayoko Ryomoto, Masahiro Hatazaki, Tetsuyuki Yasuda, Tsunehiko Yamamoto, Masahiko Gosho, Iichiro Shimomura and Hirotaka Watada

    Citation: Cardiovascular Diabetology 2021 20:95

    Content type: Original investigation

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  28. Atherogenic dyslipidemia (AD), characterized by increased concentrations of apolipoprotein B (ApoB)-containing particles, is often present in individuals with type 2 diabetes mellitus (T2DM). Non-high-density ...

    Authors: Alberto J. Lorenzatti, Maria Laura Monsalvo, J. Antonio G. López, Huei Wang and Robert S. Rosenson

    Citation: Cardiovascular Diabetology 2021 20:94

    Content type: Original investigation

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  29. Sodium–glucose cotransporter 2 inhibitor (SGLT2i) use reduces body weight (BW) in patients with type 2 diabetes mellitus (T2DM). Obesity and T2DM are strong risk factors of new-onset atrial fibrillation (AF). ...

    Authors: Yi-Hsin Chan, Shao-Wei Chen, Tze-Fan Chao, Yi-Wei Kao, Chien-Ying Huang and Pao-Hsien Chu

    Citation: Cardiovascular Diabetology 2021 20:93

    Content type: Original investigation

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  30. During the last decade we experienced a surge in the number of glucose lowering agents that can be used to treat patients with type 2 diabetes. Especially important are the discoveries that sodium glucose co-t...

    Authors: Ofri Mosenzon, Stefano Del Prato, Meir Schechter, Lawrence A. Leiter, Antonio Ceriello, Ralph A. DeFronzo and Itamar Raz

    Citation: Cardiovascular Diabetology 2021 20:92

    Content type: Review

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  31. To exam the associations between the use of sodium glucose co-transporter 2 inhibitor (SGLT2i) and the risk of lower limb complications, and to analyze the associated factors.

    Authors: Chu Lin, Xingyun Zhu, Xiaoling Cai, Wenjia Yang, Fang Lv, Lin Nie and Linong Ji

    Citation: Cardiovascular Diabetology 2021 20:91

    Content type: Original investigation

    Published on:

    The Correction to this article has been published in Cardiovascular Diabetology 2021 20:119

  32. Diabetic and obese patients are at higher risk of severe disease and cardiac injury in corona virus 2 (SARS-CoV-2) infections. Cellular entry of SARS-CoV-2 is mainly via the angiotensin-converting enzyme 2 (AC...

    Authors: Michal Herman-Edelstein, Tali Guetta, Amir Barnea, Maayan Waldman, Naomi Ben-Dor, Yaron Barak, Ran Kornowski, Michael Arad, Edith Hochhauser and Dan Aravot

    Citation: Cardiovascular Diabetology 2021 20:90

    Content type: Original investigation

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  33. The lipid-lowering and positive cardiovascular effect of proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors was shown in several studies, hence, they are more widely used in the lipid-lowering ma...

    Authors: Laurenz T. Fischer, Daniel A. Hochfellner, Lisa Knoll, Tina Pöttler, Julia K. Mader and Felix Aberer

    Citation: Cardiovascular Diabetology 2021 20:89

    Content type: Original investigation

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  34. High blood pressure is a major risk factor for cardiovascular disease. Visit-to-visit blood pressure variability (BPV) has recently been shown to predict cardiovascular outcomes. We investigated the predictive...

    Authors: Yuen-Kwun Wong, Yap-Hang Chan, JoJo S. H. Hai, Kui-Kai Lau and Hung-Fat Tse

    Citation: Cardiovascular Diabetology 2021 20:88

    Content type: Original investigation

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  35. Left ventricular (LV) longitudinal myocardial dysfunction is considered a marker of preclinical LV dysfunction in patients with type 2 diabetes mellitus (T2DM). High heart rate (HR) is associated with cardiova...

    Authors: Yuki Yamauchi, Hidekazu Tanaka, Shun Yokota, Yasuhide Mochizuki, Yuko Yoshigai, Hiroaki Shiraki, Kentaro Yamashita, Yusuke Tanaka, Ayu Shono, Makiko Suzuki, Keiko Sumimoto, Kensuke Matsumoto, Yushi Hirota, Wataru Ogawa and Ken-ichi Hirata

    Citation: Cardiovascular Diabetology 2021 20:87

    Content type: Original investigation

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  36. Chronic kidney disease (CKD) introduces an increased cardiovascular risk among patients with diabetes mellitus (DM). The risk and tempo of cardiovascular diseases may differ depending upon their type. Whether ...

    Authors: Chia-Ter Chao, Szu-Ying Lee, Jui Wang, Kuo-Liong Chien and Kuan-Yu Hung

    Citation: Cardiovascular Diabetology 2021 20:86

    Content type: Original investigation

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  37. To investigate early and long-term outcomes after treatment of carotid artery stenosis in patients with type 2 diabetes (T2D) compared to patients without T2D.

    Authors: Alexander Zabala, Anders Gottsäter, Marcus Lind, Ann-Marie Svensson, Björn Eliasson, Rebecka Bertilsson, Jan Ekelund, Thomas Nyström and Magnus Jonsson

    Citation: Cardiovascular Diabetology 2021 20:85

    Content type: Original investigation

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  38. The prognostic value of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with coronary artery disease (CAD) with different glucose status has not been established. This study sought to evaluate...

    Authors: Hui-Hui Liu, Ye-Xuan Cao, Jing-Lu Jin, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Ying Gao, Yan Zhang, Rui-Xia Xu, Qian Dong and Jian-Jun Li

    Citation: Cardiovascular Diabetology 2021 20:84

    Content type: Original investigation

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  39. Controlled studies and observational studies have shown that sodium-glucose cotransporter type 2 inhibitors (SGLT-2i) are beneficial for the survival of patients with heart failure (HF). However, it is unclear...

    Authors: Caiyun Zheng, Meimei Lin, Yan Chen, Haiting Xu, Lingqun Yan and Hengfen Dai

    Citation: Cardiovascular Diabetology 2021 20:83

    Content type: Original investigation

    Published on:

  40. The triglyceride-glucose index (TyG index) has been proposed as a simple and reliable alternative insulin resistance (IR) marker, while the homeostasis model assessment for IR (HOMA-IR) is the most frequently ...

    Authors: Shujie Wang, Juan Shi, Ying Peng, Qianhua Fang, Qian Mu, Weiqiong Gu, Jie Hong, Yifei Zhang and Weiqing Wang

    Citation: Cardiovascular Diabetology 2021 20:82

    Content type: Original investigation

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  41. To analyze incidence, use of therapeutic procedures, and in-hospital outcomes in patients with ST elevation myocardial infarction (STEMI) and non-ST elevation myocardial infarction (NSTEMI) according to the pr...

    Authors: Ana Lopez-de-Andres, Rodrigo Jimenez-Garcia, Valentin Hernández-Barrera, Jose M. de Miguel-Yanes, Romana Albaladejo-Vicente, Rosa Villanueva-Orbaiz, David Carabantes-Alarcon, Jose J. Zamorano-Leon, Marta Lopez-Herranz and Javier de Miguel-Diez

    Citation: Cardiovascular Diabetology 2021 20:81

    Content type: Original investigation

    Published on:

  42. Cardiac diastolic dysfunction (DD) and arterial stiffness are early manifestations of obesity-associated prediabetes, and both serve as risk factors for the development of heart failure with preserved ejection...

    Authors: Annayya R. Aroor, Srinivas Mummidi, Juan Carlos Lopez-Alvarenga, Nitin Das, Javad Habibi, Guanghong Jia, Guido Lastra, Bysani Chandrasekar and Vincent G. DeMarco

    Citation: Cardiovascular Diabetology 2021 20:80

    Content type: Original investigation

    Published on:

  43. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Elena M. Yubero-Serrano, Juan F. Alcalá-Diaz, Francisco M. Gutierrez-Mariscal, Antonio P. Arenas-de Larriva, Patricia J. Peña-Orihuela, Ruth Blanco-Rojo, Javier Martinez-Botas, Jose D. Torres-Peña, Pablo Perez-Martinez, Jose M. Ordovas, Javier Delgado-Lista, Diego Gómez-Coronado and Jose Lopez-Miranda

    Citation: Cardiovascular Diabetology 2021 20:79

    Content type: Correction

    Published on:

    The original article was published in Cardiovascular Diabetology 2021 20:72

  45. Patients with type 2 diabetes (T2DM) have a prothrombotic state that needs to be fully clarified; microparticles (MPs) have emerged as mediators and markers of this condition. Thus, we investigate, in vivo, in...

    Authors: Alessandra Giannella, Giulio Ceolotto, Claudia Maria Radu, Arianna Cattelan, Elisabetta Iori, Andrea Benetti, Fabrizio Fabris, Paolo Simioni, Angelo Avogaro and Saula Vigili de Kreutzenberg

    Citation: Cardiovascular Diabetology 2021 20:77

    Content type: Original investigation

    Published on:

  46. Insulin resistance has been demonstrated to be involved in the pathogenesis of atherosclerotic cardiovascular diseases (ASCVDs). This study evaluated the association between the triglyceride–glucose (TyG) inde...

    Authors: Xiaobo Ding, Xiaozhen Wang, Jing Wu, Manli Zhang and Meizi Cui

    Citation: Cardiovascular Diabetology 2021 20:76

    Content type: Original investigation

    Published on:

  47. The 6th Cardiovascular Outcome Trial (CVOT) Summit “Cardiovascular and Renal Outcomes 2020” was the first to be held virtually on October 29–30, 2020. As in previous years, this summit served as reference meet...

    Authors: Oliver Schnell, Xavier Cos, Francesco Cosentino, Thomas Forst, Francesco Giorgino, Hiddo J. L. Heersprink, Mikhail Kosiborod, Christoph Wanner and Eberhard Standl

    Citation: Cardiovascular Diabetology 2021 20:75

    Content type: Commentary

    Published on:

  48. The glucose-lowering independent effect of sodium glucose cotransporter-2 inhibitors (SGLT2i) on arterial wall function has not yet been clarified. This study aims to assess whether SGLT2i treatment can attenu...

    Authors: Andrei C. Sposito, Ikaro Breder, Alexandre A. S. Soares, Sheila T. Kimura-Medorima, Daniel B. Munhoz, Riobaldo M. R. Cintra, Isabella Bonilha, Daniela C. Oliveira, Jessica Cunha Breder, Pamela Cavalcante, Camila Moreira, Filipe A. Moura, Jose Carlos de Lima-Junior, Helison R. P. do Carmo, Joaquim Barreto, Wilson Nadruz…

    Citation: Cardiovascular Diabetology 2021 20:74

    Content type: Original investigation

    Published on:

  49. Essential hypertension and type 2 diabetes mellitus (T2DM) are two common chronic diseases that often coexist, and both of these diseases can cause heart damage. However, the additive effects of essential hype...

    Authors: Wei-feng Yan, Yue Gao, Yi Zhang, Ying-kun Guo, Jin Wang, Li Jiang, Yuan Li and Zhi-gang Yang

    Citation: Cardiovascular Diabetology 2021 20:73

    Content type: Original investigation

    Published on:

  50. Peripheral artery disease (PAD) is recognized as a significant predictor of mortality and adverse cardiovascular outcomes in patients with coronary heart disease (CHD). In fact, coexisting PAD and CHD is stron...

    Authors: Elena M. Yubero-Serrano, Juan F. Alcalá-Diaz, Francisco M. Gutierrez-Mariscal, Antonio P. Arenas-de Larriva, Patricia J. Peña-Orihuela, Ruth Blanco-Rojo, Javier Martinez-Botas, Jose D. Torres-Peña, Pablo Perez-Martinez, Jose M. Ordovas, Javier Delgado-Lista, Diego Gómez-Coronado and Jose Lopez-Miranda

    Citation: Cardiovascular Diabetology 2021 20:72

    Content type: Original investigation

    Published on:

    The Correction to this article has been published in Cardiovascular Diabetology 2021 20:79

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