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Cardiovascular Diabetology

Original investigation
Open Access

Impaired fasting glucose and left ventricular diastolic dysfunction in middle-age adults: a retrospective cross-sectional analysis of 2971 subjects

  • Assi Milwidsky†1, 6Email author,
  • Elad Maor†1, 4,
  • Shaye Kivity2, 4, 7,
  • Anat Berkovitch1,
  • Sagit Ben Zekry1, 7,
  • Alexander Tenenbaum5, 7, 8,
  • Enrique Z. Fisman7, 8,
  • Aharon Erez1,
  • Shlomo Segev3,
  • Yechezkel Sidi2, 6,
  • Ilan Goldenberg1, 6 and
  • Rafael Kuperstein1, 7
†Contributed equally
Cardiovascular Diabetology201514:119

https://doi.org/10.1186/s12933-015-0282-4

©  Milwidsky et al. 2015

Received: 22 August 2015

Accepted: 27 August 2015

Published: 15 September 2015

Abstract

Background

Left ventricular (LV) diastolic dysfunction (LVDD) is a well-established and early echocardiographic characteristic of diabetic cardiomyopathy. However, there are limited data on the association between impaired fasting glucose (IFG) and LVDD.

Objective

To determine whether IFG is associated with LVDD among middle age adults.

Methods

Amongst 3781 subjects screened in an annual health survey program and referred for an echocardiogram, 2971 individuals without LV systolic dysfunction or valvular heart disease were selected. Mean age of study population was 59 ± 12 years and 75 % were men. The subjects were categorized into three groups: euglycemia (N = 2025), IFG (N = 534) and diabetes mellitus (DM; N = 412). Doppler echocardiography readers were blinded to glycemic state. Subjects with impaired LV relaxation, pseudo-normal or restrictive filling patterns were defined as having LVDD.

Results

LVDD was diagnosed in 574 (19 %) of subjects and it was more prevalent among patients with IFG and DM than in euglycemic individuals (27, 30 and 15 %, respectively; p < 0.001). Patients with IFG and DM had lower ratios of early (E) to late (A) trans-mitral flow (0.9 ± 0.3 and 0.9 ± 0.3 vs. 1.1 ± 0.4, respectively, p < 0.001). LV hypertrophy (LVH) was also more prevalent among patients with IFG and DM (11 and 18 %, respectively, vs. 9 %; p < 0.001). Multivariate binary logistic regression model adjusted to age, gender, obesity, LVH, renal function, total, high and low density lipoprotein cholesterol, triglycerides, ischemic heart disease, hypertension and LV ejection fraction showed that patients with IFG were 43 % more likely to have LVDD compared with euglycemic subjects (95 % confidence interval 1.12–1.83, p = 0.004).

Conclusions

IFG is independently associated with a significant increase in the likelihood for the presence of LVDD in middle aged adults.

Keywords

Diastolic dysfunctionDiabetes mellitusImpaired fasting glucose

Background

Impaired fasting glucose (IFG) is a harbinger of diabetes mellitus (DM) [1], a major risk factor for cardiovascular morbidity and heart failure (HF) [2]. Early derangements in glucose metabolism are related to cardiovascular morbidity [3–5]. Previous studies have suggested that one of the earliest structural changes related to DM is left ventricular (LV) diastolic dysfunction (LVDD), preceding the emergence of systolic dysfunction and HF [6–9]. Early cardiac damage as reflected by cardiac chamber enlargement, left ventricular hypertrophy (LVH) and LV flow changes were shown to be related to impaired glucose tolerance (IGT) [10–12]. However a possible association between IFG and LVDD is controversial [13, 14]. Thus, the aim of the current study was to investigate whether IFG is associated with LVDD among a large group of middle age adults.

Methods

Study population

The study population comprised subjects who were referred for an echocardiographic examination as part of an annual medical screening program in a tertiary Medical Center. Study population was described in previous works [15–18], and includes mainly apparently healthy men and women who pass annual health screening survey examinations. Shortly, all participants are interviewed during each annual examination using standard questionnaires that gather data regarding demographic characteristics, health related habits (e.g. degree of physical activity) and medical history. An attendant physician at the center performs a complete medical interview and physical examination, including blood pressure measurement. Thereafter, blood samples are collected after a 12 h fast and analyzed immediately. All subjects undergo a maximal exercise stress test according to the Bruce protocol in each check-up. A computerized database of all annual visits in this center, since the year 2000 serves as the source of data for this study. The institutional review board of the Sheba medical center approved this study on the basis of strict maintenance of participants’ anonymity during database analysis, accordingly no individual consent was obtained.

From 01.02.2004 to 31.01.2014—a total of 22,402 subjects were screened in the annual program and 3871 of them were referred for echocardiography at the discretion of their attending physician. Subjects with systolic dysfunction (LVEF <50 %) or valvular diseases were excluded (N = 376). Additional 508 subjects were excluded due to presence of atrial fibrillation or time to completion of echocardiography of >1 year. Thus, the final study sample comprised 2971 subjects.

Echocardiographic examination and parameters

Two-dimensional transthoracic echocardiographic and Doppler studies were obtained with clinical ultrasound machines equipped with 3.5 MHz transducers using standard views. Since 2004 the studies were digitally stored (McKesson’s Horizon Cardiology™ Medical Software, Tel-Aviv, Israel). LV systolic function was visually estimated by echocardiography specialists. LVDD was defined as such by experienced readers in the echocardiographic exam summary and was determined according to accepted guidelines at the time of the study performance [19, 20], through assessment of cardiac function by pulsed-wave Doppler examination of mitral inflow and Doppler tissue imaging of the mitral annulus. All subjects with impaired LV relaxation, pseudo-normal or restrictive filling patterns were defined as having LVDD.

Interventricular diastolic septal thickness (IVSd), LV diastolic diameter (LVDd), LV systolic diameter (LVDs) and left atrial diameter were determined. Peak velocities of early (E) and late (A) trans-mitral flow and deceleration time (DT) were determined, and the ratio E/A was calculated. LV mass (LVM) was determined according to the formula introduced by Devereux et al. [21] and normalized according to body surface area (BSA) to produce LV mass index (LVMI), adjustments of LVM to Ht2.7 were also made to correct for the effect of obesity on LVM evaluation [22]. LVH was determined separately by each correction (BSA and Ht2.7) according to the American society of cardiology and European association of echocardiography guidelines. Thus, LVH was defined as LVM/BSA >95 kg/m2 for women and >115 kg/m2 for men, and as LVM/Ht2.7 >44 g/m2.7 for women and >48 g/m2.7 for men, for each criteria separately [23].

We also calculated the relative wall thickness (RWT) (measured as: twice the posterior wall thickness divided by LVDd) and determined the LV anatomical pattern in each participant (i.e. normal LV, concentric LV remodeling, concentric LVH and eccentric LVH) [24]. Normal LVM and RWT were defined as normal LV anatomy, normal LVM and RWT >0.42 as concentric LV remodeling, increased LVM and RWT >0.42 as concentric LVH and increased LVM in the presence of RWT <0.32 as eccentric LVH.

Definitions

IFG was defined according to current guidelines [25] as a 12 h fasting plasma glucose measurement between 100 and 125 in subjects without known DM. Blood samples were drawn before echocardiography (mean time to echocardiography: 74 ± 83 days). Diabetes mellitus was defined according to past or current diagnosis of DM or a fasting plasma glucose level >125 mg/dL or the use of hypoglycemic drugs. The remainder participants were defined as euglycemic.

Obesity was defined according to body mass index (BMI)—normal <25 kg/m2, overweight >25–30 kg/m2 and obese >30 kg/m2. Renal function was assessed using Cockroft–Gault formula to produce creatinine clearance (Crcl). Hypertension was defined as the presence of two blood pressure measurements >140/90 mmHg in two different occasions, a past medical diagnosis or treatment with anti-hypertensive drugs.

Statistical analysis

Continuous data were compared with student t test and one-way ANOVA. Categorical data were compared with the use of Chi square test or Fischer exact test. Trend analysis was done using polynomial one-way-anova test for parametric and the Jonckheere–Terpstra test for non-parametric variables. Multivariate binary logistic regression modeling was used to evaluate the odds ratio of LVDD among subjects according to their glycemic state (euglycemic, IFG and DM). All models were further adjusted for the following specified covariates: age, gender, hypertension, obesity, LVH (determined by LVMI and LVM/Ht2.7), ejection fraction (EF), ischemic heart disease (IHD) and renal function. Odds ratios (and 95 % confidence intervals [CI]) for LVDD in subjects with DM and IFG were compared to euglycemic participants as the reference group.

In a confirmatory sub-analysis, we also divided the cohort into tertiles according to LVM and LV anatomical pattern in each participant (i.e. normal LV, concentric LV remodeling, concentric LVH and eccentric LVH). We then replaced the main definition of LVH (according to LVMI or LVM/Ht2.7) with these two definitions (i.e. LVM tertiles and the LV anatomic patterns) as covariates in two separate binary logistic regression models (with LVDD as the dependent variable).

Interaction-term analysis was used to evaluate the consistency of the association between IFG and LVDD in specified risk subsets categorized by age, gender, creatinine clearance, hypertension, BMI, low and high density lipoprotein cholesterol levels and LV anatomical features (LVH, LVM tertiles and 4 LV anatomical subgroups). In this analysis IFG subjects were compared with euglycemics as the reference group, while those with DM were excluded. Interactions were tested separately, adjusted for all the other relevant covariates.

Statistical significance was accepted for 2-sided p < 0.05. The statistical analyses were performed with IBM SPSS version 20.0 (Chicago, IL, USA).

Results

Among 2971 study participants, mean age was 59 ± 12 and 75 % were men. There were 343 (12 %) active smokers and mean BMI was 26.8 ± 4 kg/m2. Hypertension was diagnosed in 1366 (46 %), mean systolic and diastolic blood pressures were 129 ± 18/79 ± 10 mmHg, respectively.

Among study subjects, 2025 (68 %) were euglycemic, 534 (18 %) had IFG, and 412 (14 %) had DM. The clinical and laboratory characteristics of study subjects by the three glycemic categories are presented in Table 1. The frequency of baseline clinical cardiovascular risk factors, including an older age, higher BMI, increased creatinine level, hypertension, and the presence of ischemic heart disease, was lowest in the euglycemic group and highest in the DM group (p < 0.001 both for the overall difference among the three groups and for trend, for all parameters). Total, low and high density lipoprotein cholesterol (LDL-c and HDL-c, respectively) and triglyceride levels were all significantly different between groups (p < 0.001, for all).
Table 1

Baseline clinical characteristics of study population

 

Euglycemia (2025)

IFG (534)

DM (412)

P

P for trend*

Age, years

57 ± 12

62 ± 11

65 ± 10

<0.001

<0.001

Gender, male

1410 (70 %)

450 (84 %)

347 (84 %)

<0.001

<0.001

Days to echoa

74 ± 83

71 ± 81

74 ± 84

0.63

0.62

Active smokers

237 (12 %)

53 (10 %)

53 (13 %)

0.34

0.91

Physically active

1554 (77 %)

410 (77 %)

303 (74 %)

0.25

0.12

IHD

188 (9 %)

74 (14 %)

110 (27 %)

<0.001

<0.001

BMI

26.1 ± 4

27.6 ± 4

28.5 ± 4

<0.001

<0.001

Overweight

860 (43 %)

261 (49 %)

199 (47 %)

<0.001

<0.001

Obese

299 (15 %)

129 (24 %)

136 (33 %)

<0.001

<0.001

Systolic BP (mmHg)

127 ± 18

134 ± 18

135 ± 17

<0.001

<0.001

Diastolic BP (mmHg)

79 ± 10

81 ± 10

79 ± 10

<0.001

0.03

Hypertensive

769 (38 %)

293 (55 %)

304 (74 %)

<0.001

<0.001

Glucose (mg/dL)

88 ± 8

106 ± 6

131 ± 36

<0.001

<0.001

Hemoglobin (g/dL)

14.2 ± 1

14.5 ± 1

14.0 ± 1

<0.001

0.36

CrCl (mL/min)

84 ± 24

84 ± 26

85 ± 27

0.98

0.85

T.C. (mg/dL)

185 ± 33

180 ± 34

159 ± 35

<0.001

<0.001

LDL-C (mg/dL)

113 ± 26

110 ± 26

95 ± 26

<0.001

<0.001

HDL-C (mg/dL)

50 ± 13

47 ± 11

44 ± 11

<0.001

<0.001

TG (mg/dL)

113 ± 58

131 ± 68

144 ± 83

<0.001

<0.001

BMI body mass index, BP blood pressure, CrCl creatinine clearance, DM diabetes mellitus, IFG impaired fasting glucose, HDL-C high density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, Overweight 25 < BMI ≤ 30, Obese BMI >30, T.C. total cholesterol, TG triglycerides

* Trend analysis was done using polynomial one-way-Annova test for parametric and the Jonckheere–Terpstra test for non-parametric variables

aMean number of days from blood glucose measurement to echocardiography exam

Echocardiographic indices and LVDD

LVDD was diagnosed in 574 (19 %) subjects, 473 (94.8 %) of them had grade 1 diastolic dysfunction (impaired relaxation, defined by the presence of an E/A ratio <0.8, a deceleration time >200 ms and E/E′ relation <8 in the presence of an enlarged left atrium), 23 patients a pseudo-normal pattern (4.6 %) and 3 a restrictive filling pattern (0.6 %). The mean LVEF of the entire population was 60 ± 3 %.

Echocardiographic indices of study subjects by the three glycemic groups are presented in Table 2. LV diastolic dimension and IVSd were directly correlated with the level of dysglycemia (p < 0.001 for trend, for both). LVM, LVMI, LVM/Ht2.7 and left atrium area all significantly increased from normal to IFG and DM (p < 0.001 for the overall difference among the 3 groups and for trend for all comparisons). LVH (as adjusted either for BSA or Ht2.7) was significantly more prevalent in subjects with IFG and DM compared to those who were euglycemic (p < 0.001 for both adjustments). E/A ratios were lower in subjects with IFG and DM as compared to euglycemics (p < 0.001). There was a non-significant increase in deceleration time among the 3 groups. E/E′ (early mitral flow to early mitral annular movement) ratio significantly increased with the level of dysglycemia (p < 0.001 both for the overall difference among the three groups and for trend).
Table 2

Echocardiographic parameters of study groups

BSA body surface area, E’ mitral annular movement as measures by tissue Doppler, EF ejection fraction, Dia. diastole, IVS inter ventricular septum, LA left atrium, LV left ventricle, LVDD left ventricular diastolic dysfunction, LVM_T LV mass tertile, Ms milliseconds, RWT relative wall thickness, Sys. systole

* Trend analysis was done using polynomial one-way-Annova test for parametric and the Jonckheere–Terpstra test for non-parametric variables

Notably, of 574 participants diagnosed with LVDD, only a minority met the criteria for LVH—159 (28 %) according to LVMI and 117 (20 %) according to LVM/Ht2.7.

LVDD and glycemic groups

The prevalence of LVDD was significantly higher among subjects with both IFG (27 %) and DM (30 %), as compared to euglycemic participants (15 %) (p < 0.001 for the overall difference among the three groups, and for the comparison between both the IFG and DM groups with euglycemic group; Fig. 1).
Figure 1
Fig. 1

Rate of LVDD among subjects in different glycemic groups [308 (15 %) of euglycemic, 142 (27 %) of those with IFG and 124 (30 %) of diabetic participants]. *p < 0.001 for the comparison between both IFG and DM to euglycemic groups

Univariate binary logistic regression model showed that subjects with IFG and DM were significantly more likely to have LVDD (OR = 2.01 95 % CI [1.61–2.35] and OR = 2.40, 95 % CI [1.88–3.06], respectively; p < 0.001 for both comparisons). Multivariate binary logistic regression analysis showed consistent findings (Table 3) After adjustment for age, gender, obesity, creatinine clearance, hypertension, IHD, EF, smoking status, total cholesterol, triglycerides level, LDL-c, HDL-c and LVH (determined by either LVMI or LVM/Ht2.7)—IFG and DM were shown to be independently associated with a 43 and 38 % increased likelihood for the presence of LVDD, respectively (p = 0.004 for IFG and p = 0.03 for DM).
Table 3

Binary logistic regression: effect of glycemic group on the risk for left ventricular diastolic dysfunction

 

OR

95 % CI

P value

IFG vs. normal

1.43

1.12–1.83

0.004

DM vs. normal

1.38

1.04–1.83

0.03

Age (for each 1 year)

1.07

1.06–1.09

<0.001

Gender, male

1.15

0.88–1.52

0.30

Hypertension

1.33

1.07–1.66

0.01

LVH

2.05

1.60–2.62

<0.001

BMI >25

1.44

1.12–1.84

0.005

Model is further adjusted to LVEF, IHD, renal function, smoking status, TC, TG, LDL-C and HDL-C

CI confidence interval, DM diabetes mellitus, HDL-c high density lipoprotein cholesterol, IFG impaired fasting glucose, IHD ischemic heart disease, LDL-c low density lipoprotein cholesterol, LVEF left ventricular ejection fraction, LVH left ventricular hypertrophy determined by left ventricular mass index (LVH/BSA), OR odds ratio, TC total cholesterol, TG triglycerides

Consistent findings were shown when the main definition of LVH was replaced by LVM tertiles or by the presence of an abnormal LV anatomical pattern (i.e. concentric LV remodeling, concentric LVH and eccentric LVH) as covariates in the multivariate model. This analysis showed that IFG remained independently associated to LVDD when the main definition of LVH was replaced by LVM tertiles (OR = 1.40 95 % CI [1.09–1.80]; p = 0.009) or by LV anatomical pattern (OR = 1.40 95 % CI [1.09–1.80]; p = 0.008).

Subgroup analysis was carried out in 10 specified risk subsets and is presented in Fig. 2. This analysis showed that the independent association between IFG and the likelihood for the presence of LVDD was consistent in subjects categorized by age, gender, Crcl, BMI, HDL-c, LDL-c, LVH, LVM tertiles and LV anatomy. No interaction between IFG to the specified variables was present. However, the association between IFG and LVDD was more pronounced among lower risk subjects, including those without a history of hypertension (adjusted OR = 1.88 95 % CI [1.28–2.77]) as compared to those with hypertension (adjusted OR = 1.33 95 % CI [0.98–1.82]; p value for IFG-by-hypertension interaction = 0.06), and among younger subjects (age <59; adjusted OR = 2.06 95 % CI [1.64–3.18]) as compared with older subjects (adjusted OR = 1.35 95 % CI [1.01–1.81]; p value for IFG-by-age interaction = 0.06).
Figure 2
Fig. 2

Odds ratios (and 95 % confidence intervals [CI]) for LVDD in IFG as compared with euglycemic subjects and, P values for interaction between IFG to specified (e.g. age and hypertension). The vertical line is the reference HR for LVDD in IFG compared to euglycemic subjects (=1.96). LV_Anatomy anatomical pattern, LVM_T LVM tertiles

Discussion

The main finding of the current study is that IFG is independently associated with a significant increase in the likelihood for the presence of diastolic dysfunction in middle aged adults.

This finding is further substantiated by evidence of increased LV diastolic dimensions, increased LVM, LVMI, increased LVM/Ht2.7 and increased LA dimensions, among subjects with IFG. Notably, we have also shown that the association between IFG and LVDD was independent of LV anatomical abnormalities such as concentric LV remodeling and LVH, but appeared to be more pronounced among normotensive and younger subjects in whom LVDD is generally less prevalent.

Prevalence of LVDD

The reported prevalence of diastolic dysfunction in the general population ranges from 11.1 to 34.7 % and is influenced by a number of factors including the characteristics of the population, the choice of imaging modalities and the criteria applied for diagnosing diastolic dysfunction [26]. In the present study, 574 (19 %) patients met the criteria for LVDD.

DM and LVDD

The association between DM and cardiovascular morbidity is well documented, both through increased risk for the development of coronary artery disease (CAD) and to heart failure unassociated to the presence of CAD [2]. Diastolic dysfunction precedes progression to overt heart failure either with depressed or preserved EF in many diabetic subjects [9, 27]. Actually, a recent major prospective study in patients with long standing type 1 DM, found a prevalence of 3.7 % of CHF at the end of a 7 years follow up. Diastolic HF constituted 85 % of the cases of HF [28].

IFG and LVDD

Early derangements in glucose metabolism are related to cardiovascular morbidity [3–5]. Elmm et al. followed 10,498 patients for a period of 5.2 years. Sixty five percent of the 298 patients who died during follow-up had a glucose metabolic disturbance at baseline. Importantly, IFG was associated with a hazard ratio of 2.5 for cardiovascular mortality [29].

Data regarding the association of IFG to LVDD is equivocal, for example while Shimabukuro et al. showed that IGT but not IFG is related to LVDD, Capaldo et al. recently found that both are related to reduced ratios of peak velocities of early (E) to late (A) trans-mitral flow and to increased LVM [13, 14].

Our work shows, in a large cohort of apparently healthy middle age adults that IFG is independently associated with LVDD. These results stress the fact that IFG might serve as a marker for a possible early cardiac involvement in the dysglycemic process even in the absence of other co-morbidities such as hypertension. It should be noted that both the European society for diabetes and the American diabetes association do not currently recommend routine echocardiographic screening of patients with diabetes or IFG [25, 30].

However, subclinical LVDD is recognized as an important predictor of heart failure and long-term mortality [31]. In contrast to diabetic societies current heart failure guidelines [32, 33] give special emphasis to the early detection of these asymptomatic changes of left ventricle function and the identification of its main risk factors.

In the present analysis prevalence of LVDD was similar in IFG and DM groups. This apparent paradox may be explained by the fact that many patients with DM who already suffered cardiac complications (like systolic HF, valvular disease and atrial fibrillation) were excluded from the analysis and those who left might represent a relatively healthier subgroup.

Even after multivariate analysis that included obesity, hypertension and LVH, IFG remained closely and independently related to LVDD. Interaction analysis showed that association between IFG and LVDD was strongest among young normotensive subjects (data presented in Fig. 2). This finding reinforces our hypothesis that dysglycemia itself may be related to diastolic dysfunction independently of other co-morbidities and anatomical abnormalities.

Pathogenesis of diastolic dysfunction in dysglycemia and possible treatment directions

The mechanisms underlying the relation between dysglycemia and diastolic dysfunction are many, some grouped under the term “Diabetic Cardiomyopathy” claimed by Rubler et al. [34]. and currently under rigorous investigation. These mechanisms include—fibrosis and accumulation of advanced glycosylation end products in the myocardium, cardiomyocytes lipotoxicity and direct effects of insulin on the myocardium and its vasculature, including cellular apoptosis, endothelial dysfunction and chronic adrenergic stimulation [6, 35]. Other important mechanisms included presence of insulin resistance [36–38], excessive visceral adipose tissue [39, 40], activity of circulating dipeptidyl peptidase-4 [41, 42] and fatty acid-binding protein-4 [43].

Lifestyle intervention based on dietary management and physical activity is a well-established approach to the management of various cardiometabolic diseases, including diabetes, obesity and metabolic syndrome. Increasing evidence reports favorable and specific effects of lifestyle interventions on central obesity, insulin-resistance, glucose intolerance and myocardial function [44–46].

Limitations

The main strength of our study is the relatively large cohort size under rigorous follow-up. Despite of that there are several limitations: First, this is a cross-sectional retrospective study of a selected group with risk of residual confounding. This is reinforced by the nature of our population, with a low prevalence of obesity, a good physical condition (e.g. 76 % were physically active) and an early and effective treatment for their hypertension (e.g. reflected by adequate mean blood pressure values, see Table 1). Second, the relatively high prevalence of hypertension in our study population probably could be a result from a referral bias because hypertensive patients are commonly referred for echocardiography as part of our screening program. Finally, left ventricular function was visually estimated, reflecting common clinical practice [47, 48].

Conclusion and implications

The systematic evaluation of diastolic function by echocardiography as established by the current guidelines enables a more accurate identification of cardiac abnormalities in at risk patients at an earlier and hopefully reversible stage of their disease. Our work shows that IFG is associated to LVDD among middle age adults independently of numerous factors, including concentric remodeling, LVH and obesity. These findings support evaluation of diastolic function in subjects with IFG for possible early cardiac involvement in dysglycemic process. Future prospective longitudinal studies are required to assess long-term prognosis and the reversibility of LVDD through life style modification, drug treatment and other medical interventions in these patients.

Notes

Abbreviations

BMI: 

body mass index

BP: 

blood pressure

CrCl: 

creatinine clearance, as estimated by the Cockroft–Gault formula

DM: 

diabetes mellitus

E/A ratio: 

ratio of early (E) to late (A) trans-mitral flow

EF: 

ejection fraction

HDL-c: 

high density lipoprotein cholesterol

HF: 

heart failure

Ht: 

height

HTN: 

hypertension

IFG: 

impaired fasting glucose

IHD: 

ischemic heart disease

LDL-c: 

low density lipoprotein cholesterol

LV: 

left ventricle

LVDD: 

left ventricular diastolic dysfunction

LVEF: 

left ventricular ejection fraction

LVH: 

left ventricular hypertrophy

LVM: 

left ventricle mass

Declarations

Authors’ contributions

AM: data acquisition, design of the study, drafted the manuscript; EM: carried out data analysis and participated in design and drafting of the manuscript; SK was involved in data acquisition and revision of the manuscript; AB and AE was involved in data acquisition and analysis; SBZ: critical review; AT: data interpretation and critical review; EZF: data interpretation and study design; SS was involved in data acquisition and study design; YS: data interpretation and manuscript drafting; IG was critical for study design, data analysis and interpretation and drafting of the manuscript; and RK: data interpretation, acquisition and drafting the manuscript. All authors read and approved the final manuscript.

Acknowledgements

The study was supported by a Grant from the Shalvi foundation for the support of medical research and supported in part by the Cardiovascular Diabetology Research Foundation (RA 58-040-684-1), Holon, Israel.

Compliance with ethical guidelines

Competing interests The authors declare that they have no competing interests.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Leviev Heart Center, Chaim Sheba Medical Center, Ramat Gan, Israel
(2)
Department of Internal Medicine C, Chaim Sheba Medical Center, Ramat Gan, Israel
(3)
Institute for Medical Screening, Chaim Sheba Medical Center, Ramat Gan, Israel
(4)
Pinchas Borenstein Talpiot Medical Leadership Program, Chaim Sheba Medical Center, Ramat Gan, Israel
(5)
Cardiac Rehabilitation Institute, Chaim Sheba Medical Center, Ramat Gan, Israel
(6)
Department of Internal Medicine “E”, Tel-Aviv Medical Center, Tel Aviv, Israel
(7)
Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel
(8)
Cardiovascular Diabetology Research Foundation, Holon, Israel

References

  1. Edelstein SL, Knowler WC, Bain RP, Andres R, et al. Predictors of progression from impaired glucose tolerance to NIDDM: an analysis of six prospective studies. Diabetes. 1997;46(4):701–10.PubMed CentralView ArticlePubMedGoogle Scholar
  2. Kannel WB, McGee DL. Diabetes and cardiovascular disease. The Framingham study. JAMA. 1979;241(19):2035–8.View ArticlePubMedGoogle Scholar
  3. Group DS, On Behalf of The European Diabetes Epidemiology G. Glucose tolerance and cardiovascular mortality: comparison of fasting and 2-hour diagnostic criteria. Arch Int Med. 2001;161(3):397–405.View ArticleGoogle Scholar
  4. Nathan DM, Davidson MB, DeFronzo RA, et al. Impaired fasting glucose and impaired glucose tolerance: implications for care. Diabetes Care. 2007;30(3):753–9.View ArticlePubMedGoogle Scholar
  5. Rutter MK, Parise H, Benjamin EJ, et al. Impact of glucose intolerance and insulin resistance on cardiac structure and function: sex-related differences in the Framingham Heart Study. Circulation. 2003;107(3):448–54.View ArticlePubMedGoogle Scholar
  6. Liu JE, Palmieri V, Roman MJ, et al. The impact of diabetes on left ventricular filling pattern in normotensive and hypertensive adults: the Strong Heart Study. J Am Coll Cardiol. 2001;37(7):1943–9.View ArticlePubMedGoogle Scholar
  7. Pappachan JM, Varughese GI, Sriraman R, Arunagirinathan G. Diabetic cardiomyopathy: pathophysiology, diagnostic evaluation and management. World J Diabetes. 2013;4(5):177–89.PubMed CentralPubMedGoogle Scholar
  8. Peckova M, Charvat J, Schuck O, Hill M, Svab P, Horackova M. The association between left ventricular diastolic function and a mild-to-moderate decrease in glomerular filtration rate in patients with type 2 diabetes mellitus. J Int Med Res. 2011;39(6):2178–86.View ArticlePubMedGoogle Scholar
  9. Raev DC. Which left ventricular function is impaired earlier in the evolution of diabetic cardiomyopathy? An echocardiographic study of young type I diabetic patients. Diabetes Care. 1994;17(7):633–9.View ArticlePubMedGoogle Scholar
  10. Celentano A, Vaccaro O, Tammaro P, et al. Early abnormalities of cardiac function in non-insulin-dependent diabetes mellitus and impaired glucose tolerance. Am J Cardiol. 1995;76(16):1173–6.View ArticlePubMedGoogle Scholar
  11. Bajraktari G, Koltai MS, Ademaj F, et al. Relationship between insulin resistance and left ventricular diastolic dysfunction in patients with impaired glucose tolerance and type 2 diabetes. Int J Cardiol. 2006;110(2):206–11.View ArticlePubMedGoogle Scholar
  12. Fujita M, Asanuma H, Kim J, et al. Impaired glucose tolerance: a possible contributor to left ventricular hypertrophy and diastolic dysfunction. Int J Cardiol. 2007;118(1):76–80.View ArticlePubMedGoogle Scholar
  13. Shimabukuro M, Higa N, Asahi T, et al. Impaired glucose tolerance, but not impaired fasting glucose, underlies left ventricular diastolic dysfunction. Diabetes Care. 2011;34(3):686–90.PubMed CentralView ArticlePubMedGoogle Scholar
  14. Capaldo B, Di Bonito P, Iaccarino M, et al. Cardiovascular characteristics in subjects with increasing levels of abnormal glucose regulation: the Strong Heart Study. Diabetes Care. 2013;36(4):992–7.PubMed CentralView ArticlePubMedGoogle Scholar
  15. Kopel E, Kivity S, Morag-Koren N, Segev S, Sidi Y. Relation of serum lactate dehydrogenase to coronary artery disease. Am J Cardiol. 2012;110(12):1717–22.View ArticlePubMedGoogle Scholar
  16. Maor E, Kivity S, Kopel E, et al. Differences in heart rate profile during exercise among subjects with subclinical thyroid disease. Thyroid. 2013;23(10):1226–32.View ArticlePubMedGoogle Scholar
  17. Shaye K, Amir T, Shlomo S, Yechezkel S. Fasting glucose levels within the high normal range predict cardiovascular outcome. Am Heart J. 2012;164(1):111–6.View ArticlePubMedGoogle Scholar
  18. Milwidsky A, Kivity S, Kopel E, et al. Time dependent changes in high density lipoprotein cholesterol and cardiovascular risk. Int J Cardiol. 2014;173(2):295–9.View ArticlePubMedGoogle Scholar
  19. European Study Group on Diastolic Heart Failure. How to diagnose diastolic heart failure. Eur Heart J. 1998;19(7):990–1003.View ArticleGoogle Scholar
  20. Nagueh SF, Appleton CP, Gillebert TC, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. Eur J Echocardiogr. 2009;10(2):165–93.View ArticlePubMedGoogle Scholar
  21. Devereux RB, Alonso DR, Lutas EM, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol. 1986;57(6):450–8.View ArticlePubMedGoogle Scholar
  22. Lang RM, Bierig M, Devereux RB, et al. Recommendations for chamber quantification. Eur J Echocardiogr. 2006;7(2):79–108.View ArticlePubMedGoogle Scholar
  23. Lang RM, Bierig M, Devereux RB, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18(12):1440–63.View ArticlePubMedGoogle Scholar
  24. Gaasch WH, Zile MR. Left ventricular structural remodeling in health and disease: with special emphasis on volume, mass, and geometry. J Am Coll Cardiol. 2011;58(17):1733–40.View ArticlePubMedGoogle Scholar
  25. American Diabetes Association. Standards of medical care in diabetes—2010. Diabetes Care. 2010;33(Suppl 1):S11–61.PubMed CentralView ArticleGoogle Scholar
  26. Kuznetsova T, Herbots L, Lopez B, et al. Prevalence of left ventricular diastolic dysfunction in a general population. Circ Heart Fail. 2009;2(2):105–12.View ArticlePubMedGoogle Scholar
  27. Bell DS. Diabetic cardiomyopathy. Diabetes Care. 2003;26(10):2949–51.View ArticlePubMedGoogle Scholar
  28. Konduracka E, Cieslik G, Galicka-Latala D, et al. Myocardial dysfunction and chronic heart failure in patients with long-lasting type 1 diabetes: a 7-year prospective cohort study. Acta Diabetol. 2013;50(4):597–606.PubMed CentralView ArticlePubMedGoogle Scholar
  29. Barr EL, Zimmet PZ, Welborn TA, et al. Risk of cardiovascular and all-cause mortality in individuals with diabetes mellitus, impaired fasting glucose, and impaired glucose tolerance: the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab). Circulation. 2007;116(2):151–7.View ArticlePubMedGoogle Scholar
  30. Ryden L, Grant PJ, Anker SD, et al. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). Eur Heart J. 2013;34(39):3035–87.View ArticlePubMedGoogle Scholar
  31. Rubler S, Dlugash J, Yuceoglu YZ, Kumral T, Branwood AW, Grishman A. New type of cardiomyopathy associated with diabetic glomerulosclerosis. Am J Cardiol. 1972;30(6):595–602.View ArticlePubMedGoogle Scholar
  32. Kane GC, Karon BL, Mahoney DW, et al. Progression of left ventricular diastolic dysfunction and risk of heart failure. JAMA. 2011;306:856–63.PubMed CentralView ArticlePubMedGoogle Scholar
  33. Mogelvang R, Sogaard P, Pedersen SA, et al. Cardiac dysfunction assessed by echocardiographic tissue Doppler imaging is an independent predictor of mortality in the general population. Circulation. 2009;119:2679–85.View ArticlePubMedGoogle Scholar
  34. Yancy CW, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013;62(16):e147–239.View ArticlePubMedGoogle Scholar
  35. Banerjee D, Biggs ML, Mercer L, et al. Insulin resistance and risk of incident heart failure: cardiovascular Health Study. Circ Heart Fail. 2013;6(3):364–70.PubMed CentralView ArticlePubMedGoogle Scholar
  36. Utsunomiya H, Yamamoto H, Kunita E, Hidaka T, Kihara Y. Insulin resistance and subclinical abnormalities of global and regional left ventricular function in patients with aortic valve sclerosis. Cardiovasc Diabetol. 2014;13:86.PubMed CentralView ArticlePubMedGoogle Scholar
  37. Waddingham MT, Edgley AJ, Tsuchimochi H, Kelly DJ, Shirai M, Pearson JT. Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy. World J Diabetes. 2015;6(7):943–60.PubMed CentralView ArticlePubMedGoogle Scholar
  38. Dahiya R, Shultz SP, Dahiya A, et al. Relation of reduced preclinical left ventricular diastolic function and cardiac remodeling in overweight youth to insulin resistance and inflammation. Am J Cardiol. 2015;115(9):1222–8.View ArticlePubMedGoogle Scholar
  39. Granér M, Nyman K, Siren R, et al. Ectopic fat depots and left ventricular function in nondiabetic men with nonalcoholic fatty liver disease. Circ Cardiovasc Imaging. 2015;8(1). doi:10.1161/CIRCIMAGING.114.001979
  40. Ichikawa R, Daimon M, Miyazaki T, et al. Influencing factors on cardiac structure and function beyond glycemic control in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. 2013;12:38.PubMed CentralView ArticlePubMedGoogle Scholar
  41. dos Santos L, Salles TA, Arruda-Junior DF, et al. Circulating dipeptidyl peptidase IV activity correlates with cardiac dysfunction in human and experimental heart failure. Circ Heart Fail. 2013;6(5):1029–38.View ArticlePubMedGoogle Scholar
  42. Ravassa S, Barba J, Coma-Canella I, et al. The activity of circulating dipeptidyl peptidase-4 is associated with subclinical left ventricular dysfunction in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. 2013;12:143.PubMed CentralView ArticlePubMedGoogle Scholar
  43. Fuseya T, Furuhashi M, Yuda S, et al. Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population. Cardiovasc Diabetol. 2014;13:126.PubMed CentralView ArticlePubMedGoogle Scholar
  44. Hansen D, Dendale P, van Loon LJC, Meeusen R. The impact of training modalities on the clinical benefits of exercise intervention in patients with cardiovascular disease risk or type 2 diabetes mellitus. Sports Med. 2010;40:921–40.View ArticlePubMedGoogle Scholar
  45. Serrano-Ferrer J, Walther G, Crendal E, et al. Right ventricle free wall mechanics in metabolic syndrome without type-2 diabetes: effects of a 3-month lifestyle intervention program. Cardiovasc Diabetol. 2014;13:116.PubMed CentralView ArticlePubMedGoogle Scholar
  46. Vissers D, Hens W, Taeymans J, Baeyens J-P, Poortmans J, Van Gaal L. The effect of exercise on visceral adipose tissue in overweight adults: a systematic review and meta-analysis. PLoS One. 2013;8:e56415.PubMed CentralView ArticlePubMedGoogle Scholar
  47. Shahgaldi K, Gudmundsson P, Manouras A, Brodin LA, Winter R. Visually estimated ejection fraction by two dimensional and triplane echocardiography is closely correlated with quantitative ejection fraction by real-time three dimensional echocardiography. Cardiovasc Ultrasound. 2009;7:41.PubMed CentralView ArticlePubMedGoogle Scholar
  48. Gudmundsson P, Rydberg E, Winter R, Willenheimer R. Visually estimated left ventricular ejection fraction by echocardiography is closely correlated with formal quantitative methods. Int J Cardiol. 2005;101(2):209–12.View ArticlePubMedGoogle Scholar

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