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  1. There is a paucity of global data on cardiovascular disease (CVD) prevalence in people with type 2 diabetes (T2D). The primary objective of the CAPTURE study was to estimate the prevalence of established CVD a...

    Authors: Ofri Mosenzon, Abdullah Alguwaihes, Jose Luis Arenas Leon, Fahri Bayram, Patrice Darmon, Timothy M. E. Davis, Guillermo Dieuzeide, Kirsten T. Eriksen, Tianpei Hong, Margit S. Kaltoft, Csaba Lengyel, Nicolai A. Rhee, Giuseppina T. Russo, Shinichiro Shirabe, Katerina Urbancova and Sergio Vencio

    Citation: Cardiovascular Diabetology 2021 20:154

    Content type: Original investigation

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  2. Obesity and type 2 diabetes are well-known risk factors for heart failure (HF). Although obesity has increased in type 1 diabetes, studies regarding HF in this population are scarce. Therefore, we investigated...

    Authors: Erika B. Parente, Valma Harjutsalo, Carol Forsblom and Per-Henrik Groop

    Citation: Cardiovascular Diabetology 2021 20:153

    Content type: Original investigation

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  3. Pioglitazone use is known to be associated with a reduced risk of recurrent stroke in patients with diabetes mellitus (DM) who have a history of stroke. However, it is unclear whether this benefit extends to p...

    Authors: Junghee Ha, Dong-Woo Choi, Keun You Kim, Chung Mo Nam and Eosu Kim

    Citation: Cardiovascular Diabetology 2021 20:152

    Content type: Original investigation

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  4. Succinate is produced by both host and microbiota, with a key role in the interplay of immunity and metabolism and an emerging role as a biomarker for inflammatory and metabolic disorders in middle-aged adults...

    Authors: Francisco J. Osuna-Prieto, Borja Martinez-Tellez, Lourdes Ortiz-Alvarez, Xinyu Di, Lucas Jurado-Fasoli, Huiwen Xu, Victoria Ceperuelo-Mallafré, Catalina Núñez-Roa, Isabelle Kohler, Antonio Segura-Carretero, José V. García-Lario, Angel Gil, Concepción M. Aguilera, Jose M. Llamas-Elvira, Patrick C. N. Rensen, Joan Vendrell…

    Citation: Cardiovascular Diabetology 2021 20:151

    Content type: Original investigation

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  5. Empagliflozin (EMPA), a selective inhibitor of the sodium glucose co-transporter 2, reduced the risk of hospitalization for heart failure and cardiovascular death in type 2 diabetic patients in the EMPA‐REG OU...

    Authors: Vincenzo Quagliariello, Michelino De Laurentiis, Domenica Rea, Antonio Barbieri, Maria Gaia Monti, Andreina Carbone, Andrea Paccone, Lucia Altucci, Mariarosaria Conte, Maria Laura Canale, Gerardo Botti and Nicola Maurea

    Citation: Cardiovascular Diabetology 2021 20:150

    Content type: Original investigation

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  6. Diabetic patients have an increased predisposition to thromboembolic events, in most cases originating from thrombi in the left atrial appendage (LAA). Remodeling of the LAA, which predisposes to thrombi forma...

    Authors: Or Yosefy, Barucha Sharon, Chana Yagil, Mark Shlapoberski, Alejandro Livoff, Ilana Novitski, Ronen Beeri, Yoram Yagil and Chaim Yosefy

    Citation: Cardiovascular Diabetology 2021 20:149

    Content type: Original investigation

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  7. Atrial fibrillation (AF) is prevalent in patients with type 2 diabetes mellitus (T2DM). Glycemic variability (GV) is associated with risk of micro- and macrovascular diseases. However, whether the GV can incre...

    Authors: Jung-Chi Hsu, Yen-Yun Yang, Shu-Lin Chuang, Chih-Chieh Yu and Lian-Yu Lin

    Citation: Cardiovascular Diabetology 2021 20:148

    Content type: Original investigation

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  8. Both visceral adipose tissue and epicardial adipose tissue (EAT) have pro-inflammatory properties. The former is associated with Coronavirus Disease 19 (COVID-19) severity. We aimed to investigate whether an a...

    Authors: Hélène Bihan, Richard Heidar, Aude Beloeuvre, Lucie Allard, Elise Ouedraogo, Sopio Tatulashvili, Yacine Tandjaoui, Stephane Gaudry, Pierre-Yves Brillet and Emmanuel Cosson

    Citation: Cardiovascular Diabetology 2021 20:147

    Content type: Original investigation

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  9. Triglyceride–glucose (TyG) index, a simple surrogate marker of insulin resistance, has been reported to be associated with arterial stiffness. However, previous studies were limited by the cross-sectional desi...

    Authors: Shouling Wu, Luli Xu, Mingyang Wu, Shuohua Chen, Youjie Wang and Yaohua Tian

    Citation: Cardiovascular Diabetology 2021 20:146

    Content type: Original investigation

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  10. Multiple modifiable risk factors for late complications in patients with diabetic kidney disease (DKD), including hyperglycemia, hypertension and dyslipidemia, increase the risk of a poor outcome. DKD is assoc...

    Authors: Ferdinando Carlo Sasso, Pia Clara Pafundi, Vittorio Simeon, Luca De Nicola, Paolo Chiodini, Raffaele Galiero, Luca Rinaldi, Riccardo Nevola, Teresa Salvatore, Celestino Sardu, Raffaele Marfella, Luigi Elio Adinolfi and Roberto Minutolo

    Citation: Cardiovascular Diabetology 2021 20:145

    Content type: Original investigation

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  11. This cross-sectional study aimed to identify actionable factors to improve LDL-cholesterol target achievement and overcome underuse of lipid-lowering treatments in high- or very-high-cardiovascular risk patients.

    Authors: Mario Luca Morieri, Valentina Perrone, Chiara Veronesi, Luca Degli Esposti, Margherita Andretta, Mario Plebani, Gian Paolo Fadini, Saula Vigili de Kreutzenberg and Angelo Avogaro

    Citation: Cardiovascular Diabetology 2021 20:144

    Content type: Original investigation

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  12. Fibrinogen (FIB) is an independent risk factor for mortality and cardiovascular events in the general population. However, the relationship between FIB and long-term mortality among CAD patients undergoing PCI...

    Authors: Deshan Yuan, Ping Jiang, Pei Zhu, Sida Jia, Ce Zhang, Yue Liu, Ru Liu, Jingjing Xu, Xiaofang Tang, Xueyan Zhao, Runlin Gao, Yuejin Yang, Bo Xu, Zhan Gao and Jinqing Yuan

    Citation: Cardiovascular Diabetology 2021 20:143

    Content type: Original investigation

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  13. Some studies have suggested that patients with diabetes and foot complications have worse cardiovascular and cerebrovascular risk profiles, higher degrees of endothelial dysfunction and arterial stiffness and ...

    Authors: Antonino Tuttolomondo, Alessandro Del Cuore, Alessandro La Malfa, Alessandra Casuccio, Mario Daidone, Carlo Domenico Maida, Domenico Di Raimondo, Tiziana Di Chiara, Maria Grazia Puleo, Rosario Norrito, Giovanni Guercio and Antonio Pinto

    Citation: Cardiovascular Diabetology 2021 20:142

    Content type: Original investigation

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  14. To examine the impact of weight change on incident cardiovascular disease and coronary heart disease (CVD/CHD) among an Iranian population with type 2 diabetes mellitus (T2DM).

    Authors: Seyyed Saeed Moazzeni, Reyhane Hizomi Arani, Niloofar Deravi, Mitra Hasheminia, Davood Khalili, Fereidoun Azizi and Farzad Hadaegh

    Citation: Cardiovascular Diabetology 2021 20:141

    Content type: Original investigation

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  15. The pleiotropic effects of statins may reduce the severity of COVID-19 disease. This study aims to determine the association between inpatient statin use and severe disease outcomes among hospitalized COVID-19...

    Authors: Prateek Lohia, Shweta Kapur, Sindhuri Benjaram, Zachary Cantor, Navid Mahabadi, Tanveer Mir and M. Safwan Badr

    Citation: Cardiovascular Diabetology 2021 20:140

    Content type: Original investigation

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  16. Evidence from prospective cardiovascular (CV) outcome trials in type 2 diabetes (T2DM) patients supports the use of sodium–glucose co-transporter-2 inhibitors (SGLT2i) to reduce the risk of CV events. In this ...

    Authors: Jordi Real, Bogdan Vlacho, Emilio Ortega, Joan Antoni Vallés, Manel Mata-Cases, Esmeralda Castelblanco, Eric T. Wittbrodt, Peter Fenici, Mikhail Kosiborod, Dídac Mauricio and Josep Franch-Nadal

    Citation: Cardiovascular Diabetology 2021 20:139

    Content type: Original investigation

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  17. To analyze incidence, use of therapeutic procedures, use of oral anticoagulants (OACs) and antiplatelet agents prior to hospitalization, and in-hospital outcomes among patients who were hospitalized with hemor...

    Authors: Ana Lopez-de-Andres, Rodrigo Jimenez-Garcia, Valentín Hernández-Barrera, Isabel Jiménez-Trujillo, José M. de Miguel-Yanes, David Carabantes-Alarcon, Javier de Miguel-Diez and Marta Lopez-Herranz

    Citation: Cardiovascular Diabetology 2021 20:138

    Content type: Original investigation

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  18. The triglyceride-glucose (TyG) index is an alternative marker of insulin resistance (IR) and is closely associated with the prevalence and prognosis of atherosclerotic cardiovascular disease (ASCVD). However, ...

    Authors: Yong Zhu, Kesen Liu, Maolin Chen, Yan Liu, Ang Gao, Chengping Hu, Hong Li, Huagang Zhu, Hongya Han, Jianwei Zhang and Yingxin Zhao

    Citation: Cardiovascular Diabetology 2021 20:137

    Content type: Original investigation

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  19. To compare left ventricular structure (LV) and diastolic function in young adults with youth- onset diabetes by type, determine the prevalence of abnormal diastolic function by diabetes type using published va...

    Authors: Amy S. Shah, Scott Isom, Dana Dabelea, Ralph D’Agostino Jr., Lawrence M. Dolan, Lynne Wagenknecht, Giuseppina Imperatore, Sharon Saydah, Angela D. Liese, Jean M. Lawrence, Cate Pihoker and Elaine M. Urbina

    Citation: Cardiovascular Diabetology 2021 20:136

    Content type: Original investigation

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  20. Lower extremity amputations (LEA) are associated with a high mortality and medical expenditure. Diabetes accounts for 45% to 70% of LEA and is one of the most potent risk factors for peripheral artery diseases...

    Authors: Paola Caruso, Lorenzo Scappaticcio, Maria Ida Maiorino, Katherine Esposito and Dario Giugliano

    Citation: Cardiovascular Diabetology 2021 20:135

    Content type: Commentary

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  21. Cross-sectional studies have reported that insulin resistance (IR) is associated with arterial stiffness. However, the relationship between IR and arterial stiffness progression remains unclear. This study aim...

    Authors: Zhiyuan Wu, Di Zhou, Yue Liu, Zhiwei Li, Jinqi Wang, Ze Han, Xinlei Miao, Xiangtong Liu, Xia Li, Wei Wang, Xiuhua Guo and Lixin Tao

    Citation: Cardiovascular Diabetology 2021 20:134

    Content type: Original investigation

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  22. The prognostic importance of several hematological parameters has been scarcely investigated in type 2 diabetes. So, we aimed to evaluate their prognostic importance for development of complications in a cohor...

    Authors: Claudia R. L. Cardoso, Nathalie C. Leite and Gil F. Salles

    Citation: Cardiovascular Diabetology 2021 20:133

    Content type: Original investigation

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  23. Myocardial fibrosis is a multistep process, which results in collagen deposition in the injured muscle. Empagliflozin, a sodium-glucose cotransporter 2 inhibitor (SGLT2i), decreases cardiovascular events risk....

    Authors: Elias Daud, Offir Ertracht, Nadav Bandel, Gassan Moady, Monah Shehadeh, Tali Reuveni and Shaul Atar

    Citation: Cardiovascular Diabetology 2021 20:132

    Content type: Original investigation

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  24. This prospective study explored plaque morphology according to the underlying culprit lesion pathology (rupture versus erosion) in relation to the triglyceride glucose (TyG) index in patients with acute ST-ele...

    Authors: Xiaoxiao Zhao, Ying Wang, Runzhen Chen, Jiannan Li, Jinying Zhou, Chen Liu, Peng Zhou, Zhaoxue Sheng, Yi Chen, Li Song, Hanjun Zhao and Hongbing Yan

    Citation: Cardiovascular Diabetology 2021 20:131

    Content type: Original investigation

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  25. Sodium-glucose co-transporter-2 inhibitors (SGLT-2is) are licenced for initiation for glucose lowering in people with type 2 diabetes (T2DM) with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73m2)...

    Authors: William Hinton, Michael D. Feher, Neil Munro, Mark Joy and Simon de Lusignan

    Citation: Cardiovascular Diabetology 2021 20:130

    Content type: Original investigation

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  26. Sodium glucose co-transporter 2 inhibitors promote osmotic/natriuretic diuresis and reduce excess fluid volume, and this improves cardiovascular outcomes, including hospitalization for heart failure. We sought...

    Authors: Atsushi Tanaka, Michio Shimabukuro, Hiroki Teragawa, Yosuke Okada, Toshinari Takamura, Isao Taguchi, Shigeru Toyoda, Hirofumi Tomiyama, Shinichiro Ueda, Yukihito Higashi and Koichi Node

    Citation: Cardiovascular Diabetology 2021 20:105

    Content type: Original investigation

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  27. Advanced glycation end-products are proteins that become glycated after contact with sugars and are implicated in endothelial dysfunction and arterial stiffening. We aimed to investigate the relationships betw...

    Authors: Anna Birukov, Rafael Cuadrat, Elli Polemiti, Fabian Eichelmann and Matthias B. Schulze

    Citation: Cardiovascular Diabetology 2021 20:110

    Content type: Original investigation

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  28. To identify occupations where employees with type 2 diabetes have a high risk of cardiovascular disease (CVD) and mortality, and their prevalence of CVD risk factors. This study can contribute in the creation ...

    Authors: Sofia Carlsson, Tomas Andersson, Mats Talbäck and Maria Feychting

    Citation: Cardiovascular Diabetology 2021 20:129

    Content type: Original investigation

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  29. The global burden of atrial fibrillation (AF) and diabetes mellitus (DM) is constantly rising, leading to an increasing healthcare burden of stroke. AF often remains undiagnosed due to the occurrence in an asy...

    Authors: Jakub Gumprecht, Gregory Y. H. Lip, Adam Sokal, Beata Średniawa, Katarzyna Mitręga, Jakub Stokwiszewski, Łukasz Wierucki, Aleksandra Rajca, Marcin Rutkowski, Tomasz Zdrojewski, Tomasz Grodzicki, Jarosław Kaźmierczak, Grzegorz Opolski and Zbigniew Kalarus

    Citation: Cardiovascular Diabetology 2021 20:128

    Content type: Original investigation

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  30. ANGPTL8, an important regulator of lipid metabolism, was recently proven to have additional intracellular and receptor-mediated functions. This study aimed to investigate circulating levels of ANGPTL8 and its ...

    Authors: Huajie Zou, Yongping Xu, Xiaoyu Meng, Danpei Li, Xi Chen, Tingting Du, Yan Yang, Yong Chen, Shiying Shao, Gang Yuan, Xinrong Zhou, Shuhong Hu, Wentao He, Delin Ma, Junhui Xie, Benping Zhang…

    Citation: Cardiovascular Diabetology 2021 20:127

    Content type: Original investigation

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  31. It remains unclear whether triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, is prospectively associated with incident peripheral arterial disease (PAD).

    Authors: Jing-Wei Gao, Qing-Yun Hao, Ming Gao, Kun Zhang, Xiong-Zhi Li, Jing-Feng Wang, Dominique A. Vuitton, Shao-Ling Zhang and Pin-Ming Liu

    Citation: Cardiovascular Diabetology 2021 20:126

    Content type: Original investigation

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  32. In stable patients with type 2 diabetes (T2D), insulin treatment is associated with elevated risk for major adverse cardiovascular events (MACE). Patients with acute coronary syndrome (ACS) and T2D are at part...

    Authors: Gregory G. Schwartz, Stephen J. Nicholls, Peter P. Toth, Michael Sweeney, Christopher Halliday, Jan O. Johansson, Norman C. W. Wong, Ewelina Kulikowski, Kamyar Kalantar-Zadeh, Henry N. Ginsberg and Kausik K. Ray

    Citation: Cardiovascular Diabetology 2021 20:125

    Content type: Original investigation

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  33. Type 2 diabetes mellitus (T2D) increases the risk of incident heart failure (HF), whose earliest fingerprint is effort intolerance (i.e. impaired peak oxygen consumption, or VO2peak). In the uncomplicated T2D pop...

    Authors: Lorenzo Nesti, Nicola Riccardo Pugliese, Paolo Sciuto, Nicolò De Biase, Matteo Mazzola, Iacopo Fabiani, Domenico Trico, Stefano Masi and Andrea Natali

    Citation: Cardiovascular Diabetology 2021 20:124

    Content type: Original investigation

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  34. Diabetes has strongly been linked to atrial fibrillation, ischaemic heart disease and heart failure. The epidemiology of these cardiovascular diseases is changing, however, due to changes in prevalence of obes...

    Authors: Amy Groenewegen, Victor W. Zwartkruis, Betül Cekic, Rudolf. A. de Boer, Michiel Rienstra, Arno W. Hoes, Frans H. Rutten and Monika Hollander

    Citation: Cardiovascular Diabetology 2021 20:123

    Content type: Original investigation

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  35. Disturbances of glucose metabolism can be diagnosed by an oral glucose tolerance test (OGTT) and by glycated haemoglobin (HbA1c). The aim of this study was to investigate the association between newly detected...

    Authors: Stelios Karayiannides, Catarina Djupsjö, Jeanette Kuhl, Claes Hofman-Bang, Anna Norhammar, Martin J. Holzmann and Pia Lundman

    Citation: Cardiovascular Diabetology 2021 20:122

    Content type: Original investigation

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  36. Cardiac remodeling is one of the major risk factors for heart failure. In patients with type 2 diabetes, sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of the first hospitalization for heart...

    Authors: Yuze Zhang, Xiaoyan Lin, Yong Chu, Xiaoming Chen, Heng Du, Hailin Zhang, Changsheng Xu, Hong Xie, Qinyun Ruan, Jinxiu Lin, Jie Liu, Jinzhang Zeng, Ke Ma and Dajun Chai

    Citation: Cardiovascular Diabetology 2021 20:121

    Content type: Original investigation

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  37. Information about the renin–angiotensin–aldosterone system (RAAS) in obese individuals before and after bariatric surgery is scarce. Aim of this study was to analyze the RAAS in severely obese subjects, in rel...

    Authors: Lucia La Sala, Elena Tagliabue, Elaine Vieira, Antonio E Pontiroli and Franco Folli

    Citation: Cardiovascular Diabetology 2021 20:118

    Content type: Original investigation

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  38. Diabetes is associated with a significantly elevated risk of cardiovascular disease and its specific pathophysiology remains unclear. Recent studies have changed our understanding of cardiac cellularity, with ...

    Authors: Charles D. Cohen, Miles J. De Blasio, Man K. S. Lee, Gabriella E. Farrugia, Darnel Prakoso, Crisdion Krstevski, Minh Deo, Daniel G. Donner, Helen Kiriazis, Michelle C. Flynn, Taylah L. Gaynor, Andrew J. Murphy, Grant R. Drummond, Alexander R. Pinto and Rebecca H. Ritchie

    Citation: Cardiovascular Diabetology 2021 20:116

    Content type: Original investigation

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  39. Prior studies in animal models showed that increased cardiac expression of TRIB3 has a pathogenic role in inducing left ventricular mass (LVM). Whether alterations in TRIB3 expression or function have a pathog...

    Authors: Gaia Chiara Mannino, Carolina Averta, Teresa Vanessa Fiorentino, Elena Succurro, Rosangela Spiga, Elettra Mancuso, Sofia Miceli, Maria Perticone, Angela Sciacqua, Francesco Andreozzi and Giorgio Sesti

    Citation: Cardiovascular Diabetology 2021 20:115

    Content type: Original investigation

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  40. Carotid atherosclerosis represents one of the complications of diabetes mellitus. In particular, plaque instability contributes to disease progression and stroke incidence. High mobility group box-1 (HMGB1) is...

    Authors: Federico Biscetti, Giovanni Tinelli, Maria Margherita Rando, Elisabetta Nardella, Andrea Leonardo Cecchini, Flavia Angelini, Giuseppe Straface, Marco Filipponi, Vincenzo Arena, Dario Pitocco, Antonio Gasbarrini, Massimo Massetti and Andrea Flex

    Citation: Cardiovascular Diabetology 2021 20:114

    Content type: Original investigation

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  41. Previous studies has shown a significant relationship between baseline triglyceride-glucose (TyG) index and subsequent cardiovascular disease (CVD). However, the effect of longitudinal changes in TyG index on ...

    Authors: Anxin Wang, Xue Tian, Yingting Zuo, Shuohua Chen, Xia Meng, Shouling Wu and Yongjun Wang

    Citation: Cardiovascular Diabetology 2021 20:113

    Content type: Original investigation

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  42. In a recently published paper in Cardiovascular Diabetology, Sinha et al. (Association of fasting glucose with lifetime risk of incident heart failure: the Lifetime Risk Pooling Project. Cardiovasc Diabetol. 2021...

    Authors: Jian-di Wu, Dong-liang Liang and Yue Xie

    Citation: Cardiovascular Diabetology 2021 20:112

    Content type: Commentary

    Published on:

  43. The metabolic syndrome (MetS), defined by the simultaneous clustering of cardio-metabolic risk factors, is a significant worldwide public health burden with an estimated 25% prevalence worldwide. The pathogene...

    Authors: Mohamed A. Elhadad, Rory Wilson, Shaza B. Zaghlool, Cornelia Huth, Christian Gieger, Harald Grallert, Johannes Graumann, Wolfgang Rathmann, Wolfgang Koenig, Moritz F. Sinner, Kristian Hveem, Karsten Suhre, Barbara Thorand, Christian Jonasson, Melanie Waldenberger and Annette Peters

    Citation: Cardiovascular Diabetology 2021 20:111

    Content type: Original investigation

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  44. Since 1985, the thiazolidinedione pioglitazone has been widely used as an insulin sensitizer drug for type 2 diabetes mellitus (T2DM). Although fluid retention was early recognized as a safety concern, data fr...

    Authors: Lorenzo Nesti, Domenico Tricò, Alessandro Mengozzi and Andrea Natali

    Citation: Cardiovascular Diabetology 2021 20:109

    Content type: Review

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  45. Diabetes mellitus (DM) and depression are bidirectionally interrelated. We recently identified long-term trajectories of depression symptom severity in individuals with coronary heart disease (CHD), which were...

    Authors: Raphael S. Peter, Andrea Jaensch, Ute Mons, Ben Schöttker, Roman Schmucker, Wolfgang Koenig, Hermann Brenner and Dietrich Rothenbacher

    Citation: Cardiovascular Diabetology 2021 20:108

    Content type: Original investigation

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  46. In a recent meta-analysis of randomized controlled trials of sodium glucose co-transporter 2 inhibitors (SGLT2i) in patients with diabetes, Lin and colleagues showed a positive association between SGLT2i-induc...

    Authors: Louis Potier, Kamel Mohammedi, Gilberto Velho and Ronan Roussel

    Citation: Cardiovascular Diabetology 2021 20:107

    Content type: Commentary

    Published on:

  47. Type 2 diabetes mellitus (DM) is one of the most common comorbidities among patients with heart failure (HF) with reduced ejection fraction (HFrEF). There are limited data regarding efficacy of hybrid comprehe...

    Authors: Renata Główczyńska, Ewa Piotrowicz, Dominika Szalewska, Ryszard Piotrowicz, Ilona Kowalik, Michael J. Pencina, Wojciech Zaręba, Maciej Banach, Piotr Orzechowski, Sławomir Pluta, Robert Irzmański, Zbigniew Kalarus and Grzegorz Opolski

    Citation: Cardiovascular Diabetology 2021 20:106

    Content type: Original investigation

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