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Cardiovascular Diabetology


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  1. Content type: Original investigation

    The severity of the metabolic syndrome (MetS) is significantly associated with future coronary heart disease (CHD) among individuals without baseline Type 2 diabetes. However, the validity of assessing MetS se...

    Authors: Matthew J. Gurka, Yi Guo, Stephanie L. Filipp and Mark D. DeBoer

    Citation: Cardiovascular Diabetology 2018 17:17

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  2. Content type: Original investigation

    The risk of diabetic complications is modified by genetic and epigenetic factors. p66Shc drives the hyperglycaemic cell damage and its deletion prevents experimental diabetic complications. We herein tested wheth...

    Authors: Gian Paolo Fadini, Mattia Albiero, Benedetta Maria Bonora, Nicol Poncina, Saula Vigili de Kreutzenberg and Angelo Avogaro

    Citation: Cardiovascular Diabetology 2018 17:16

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  3. Content type: Original investigation

    Increased reactive oxygen species (ROS) generation in diabetes mellitus (DM) is an important mechanism leading to diabetic cardiomyopathy. Apocynin, a drug isolated from the herb Picrorhiza kurroa, is considered ...

    Authors: R. Gimenes, C. Gimenes, C. M. Rosa, N. P. Xavier, D. H. S. Campos, A. A. H. Fernandes, M. D. M. Cezar, G. N. Guirado, L. U. Pagan, I. D. Chaer, D. C. Fernandes, F. R. Laurindo, A. C. Cicogna, M. P. Okoshi and K. Okoshi

    Citation: Cardiovascular Diabetology 2018 17:15

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  4. Content type: Original investigation

    Measurement of systolic and diastolic function in animal models is challenging by conventional non-invasive methods. Therefore, we aimed at comparing speckle-tracking echocardiography (STE)-derived parameters ...

    Authors: Csaba Mátyás, Attila Kovács, Balázs Tamás Németh, Attila Oláh, Szilveszter Braun, Márton Tokodi, Bálint András Barta, Kálmán Benke, Mihály Ruppert, Bálint Károly Lakatos, Béla Merkely and Tamás Radovits

    Citation: Cardiovascular Diabetology 2018 17:13

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  5. Content type: Original investigation

    Haptoglobin (Hp) functions as an antioxidant by binding with haemoglobin. We investigated whether serum Hp has a causal effect on macroangiopathy via Mendelian randomization (MR) analysis with common variants ...

    Authors: Shiyun Wang, Jie Wang, Rong Zhang, Tao Wang, Dandan Yan, Zhen He, Feng Jiang, Cheng Hu and Weiping Jia

    Citation: Cardiovascular Diabetology 2018 17:14

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  6. Content type: Original investigation

    Albuminuria is of one the strongest predictors of cardiovascular disease (CVD) in diabetes. Diabetes is associated with cardiac microvascular dysfunction (CMD), a powerful, independent prognostic factor for ca...

    Authors: Louis Potier, Renata Chequer, Ronan Roussel, Kamel Mohammedi, Souad Sismail, Agnès Hartemann, Chloé Amouyal, Michel Marre, Dominique Le Guludec and Fabien Hyafil

    Citation: Cardiovascular Diabetology 2018 17:11

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  7. Content type: Original investigation

    Statins are widely used for lipid lowering in patients with coronary artery disease (CAD), but increasing evidence indicates an association between statin use and new-onset of diabetes mellitus (NODM). Epicard...

    Authors: Jeehoon Kang, Young-Chan Kim, Jin Joo Park, Sehun Kim, Si-Hyuck Kang, Young Jin Cho, Yeonyee E. Yoon, Il-Young Oh, Chang-Hwan Yoon, Jung-Won Suh, Young-Seok Cho, Tae-Jin Youn, In-Ho Chae and Dong-Ju Choi

    Citation: Cardiovascular Diabetology 2018 17:10

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  8. Content type: Original investigation

    The distribution of glucose and fatty-acid transporters in the heart is crucial for energy consecution and myocardial function. In this sense, the glucagon-like peptide-1 (GLP-1) enhancer, sitagliptin, improve...

    Authors: E. Ramírez, B. Picatoste, A. González-Bris, M. Oteo, F. Cruz, A. Caro-Vadillo, J. Egido, J. Tuñón, M. A. Morcillo and Ó. Lorenzo

    Citation: Cardiovascular Diabetology 2018 17:12

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  9. Content type: Original investigation

    Incretin-based therapies are used in the treatment of type 2 diabetes mellitus (T2DM) and obesity. We investigated the changes in arterial stiffness and left ventricular (LV) myocardial deformation after 6-mon...

    Authors: Vaia Lambadiari, George Pavlidis, Foteini Kousathana, Maria Varoudi, Dimitrios Vlastos, Eirini Maratou, Dimitrios Georgiou, Ioanna Andreadou, John Parissis, Helen Triantafyllidi, John Lekakis, Efstathios Iliodromitis, George Dimitriadis and Ignatios Ikonomidis

    Citation: Cardiovascular Diabetology 2018 17:8

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  10. Content type: Review

    Drugs that inhibit dipeptidyl peptidase-4 (DPP-4) are conventionally regarded as incretin-based agents that signal through the glucagon-like peptide-1 (GLP-1) receptor. However, inhibition of DPP-4 also potent...

    Authors: Milton Packer

    Citation: Cardiovascular Diabetology 2018 17:9

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  11. Content type: Original investigation

    Glycosuria produced by sodium–glucose co-transporter-2 (SGLT-2) inhibitors is associated with weight loss. SGLT-2 inhibitors reportedly might reduce the occurrence of cardiovascular events. Epicardial adipose ...

    Authors: Takao Sato, Yoshifusa Aizawa, Sho Yuasa, Shohei Kishi, Koichi Fuse, Satoshi Fujita, Yoshio Ikeda, Hitoshi Kitazawa, Minoru Takahashi, Masahito Sato and Masaaki Okabe

    Citation: Cardiovascular Diabetology 2018 17:6

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  12. Content type: Original investigation

    Sodium tissue content by 23Na magnetic resonance imaging (Na-MRI) has been validated in experimental and human studies. SGLT-2 inhibition blocks the reabsorption of glucose and of sodium in the proximal tubular c...

    Authors: M. V. Karg, A. Bosch, D. Kannenkeril, K. Striepe, C. Ott, M. P. Schneider, F. Boemke-Zelch, P. Linz, A. M. Nagel, J. Titze, M. Uder and R. E. Schmieder

    Citation: Cardiovascular Diabetology 2018 17:5

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  13. Content type: Original investigation

    Cardiac magnetic resonance (CMR) T1 mapping and tissue-tracking strain analysis are useful quantitative techniques that can characterize myocardial tissue and mechanical alterations, respectively, in patients ...

    Authors: Yukun Cao, Wenjuan Zeng, Yue Cui, Xiangchuang Kong, Miao Wang, Jie Yu, Shan Zhang, Jing Song, Xu Yan, Andreas Greiser and Heshui Shi

    Citation: Cardiovascular Diabetology 2018 17:7

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  14. Content type: Original investigation

    The cardiovascular safety and efficacy of linagliptin, a dipeptidyl peptidase-4 inhibitor, in patients with type 2 diabetes mellitus (T2DM) after acute coronary syndrome (ACS) or acute ischemic stroke (AIS) ar...

    Authors: Yan-Rong Li, Sung-Sheng Tsai, Dong-Yi Chen, Szu-Tah Chen, Jui-Hung Sun, Hung-Yu Chang, Miaw-Jene Liou and Tien-Hsing Chen

    Citation: Cardiovascular Diabetology 2018 17:2

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  15. Content type: Commentary

    NG-Methylation of l-arginine (Arg) residues in certain proteins by protein arginine methyltransferases and subsequent proteolysis yields NG-monomethyl-l-arginine (MMA), NG,NG-dimethyl-l-arginine (asymmetric dimet...

    Authors: Dimitrios Tsikas, Alexander Bollenbach, Erik Hanff and Arslan Arinc Kayacelebi

    Citation: Cardiovascular Diabetology 2018 17:1

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  16. Content type: Original investigation

    Data on the influence of glycemic status on the progression of coronary calcification, an important marker for future adverse cardiovascular events, are limited.

    Authors: Ki-Bum Won, Donghee Han, Ji Hyun Lee, Sang-Eun Lee, Ji Min Sung, Su-Yeon Choi, Eun Ju Chun, Sung Hak Park, Hae-Won Han, Jidong Sung, Hae Ok Jung and Hyuk-Jae Chang

    Citation: Cardiovascular Diabetology 2018 17:4

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  17. Content type: Commentary

    A recent study found that among individuals with a preserved left ventricular ejection fraction ≥ 55%, global longitudinal strain was significantly lower in overweight patients (i.e., body mass index ≥ 25 kg/m2) ...

    Authors: Katrine Dina Musaeus and Manan Pareek

    Citation: Cardiovascular Diabetology 2018 17:3

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  18. Content type: Original investigation

    Attenuated increases in ventricular stroke volume during exercise are common in type 2 diabetes and contribute to reduced aerobic capacity. The purpose of this study was to determine whether impaired ventricul...

    Authors: Genevieve A. Wilson, Gerard T. Wilkins, Jim D. Cotter, Regis R. Lamberts, Sudish Lal and James C. Baldi

    Citation: Cardiovascular Diabetology 2017 16:160

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  19. Content type: Original investigation

    Whether dipeptidyl peptidase-4 inhibitor (DPP4i) is associated with a lower risk of new-onset atrial fibrillation (AF) in patients with diabetes remains unclear. This study aimed to evaluate the risk of AF ass...

    Authors: Chia-Yu Chang, Yung-Hsin Yeh, Yi-Hsin Chan, Jia-Rou Liu, Shang-Hung Chang, Hsin-Fu Lee, Lung-Sheng Wu, Kun-Chi Yen, Chi-Tai Kuo and Lai-Chu See

    Citation: Cardiovascular Diabetology 2017 16:159

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  20. Content type: Original investigation

    Elevated levels of low-density lipoprotein cholesterol (LDL-C) and glycosylated hemoglobin (HbA1c) are risk factors for cardiovascular complications. This study evaluated LDL-C goal attainment in Russian clini...

    Authors: Sergey Boytsov, Natalia Logunova and Yunona Khomitskaya

    Citation: Cardiovascular Diabetology 2017 16:158

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  21. Content type: Original investigation

    Hyperglycemia is associated with increased morbidity and mortality in patients with an acute myocardial infarction (AMI). We evaluated whether complications after AMI are associated with absolute or relative g...

    Authors: Tien F. Lee, Morton G. Burt, Leonie K. Heilbronn, Arduino A. Mangoni, Vincent W. Wong, Mark McLean and N. Wah Cheung

    Citation: Cardiovascular Diabetology 2017 16:157

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  22. Content type: Original investigation

    Coronary atherosclerosis progresses faster in patients with diabetes mellitus (DM) and causes higher morbidity and mortality in such patients compared to non-diabetics ones (non-DM). We quantify changes in pla...

    Authors: Tomas Kovarnik, Zhi Chen, Gary S. Mintz, Andreas Wahle, Kristyna Bayerova, Ales Kral, Martin Chval, Karel Kopriva, John Lopez, Milan Sonka and Ales Linhart

    Citation: Cardiovascular Diabetology 2017 16:156

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  23. Content type: Review

    Cardiovascular disease, predominantly ischemic heart disease (IHD), is the leading cause of death in diabetes mellitus (DM). In addition to eliciting cardiomyopathy, DM induces a ‘wicked triumvirate’: (i) incr...

    Authors: Jake Russell, Eugene F. Du Toit, Jason N. Peart, Hemal H. Patel and John P. Headrick

    Citation: Cardiovascular Diabetology 2017 16:155

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  24. Content type: Original investigation

    The potential of anti-aging effect of DPP-4 inhibitors is unknown. This study was performed to determine whether linagliptin, a DPP-4 inhibitor, could protect against premature aging in klotho−/− mice.

    Authors: Yu Hasegawa, Kenyu Hayashi, Yushin Takemoto, Cao Cheng, Koki Takane, Bowen Lin, Yoshihiro Komohara and Shokei Kim-Mitsuyama

    Citation: Cardiovascular Diabetology 2017 16:154

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  25. Content type: Original investigation

    Biomarkers of inflammation and adiponectin are associated with cardiovascular autonomic neuropathy (CAN) in cross-sectional studies, but prospective data are scarce. This study aimed to assess the associations...

    Authors: Christian Stevns Hansen, Dorte Vistisen, Marit Eika Jørgensen, Daniel R. Witte, Eric J. Brunner, Adam G. Tabák, Mika Kivimäki, Michael Roden, Marek Malik and Christian Herder

    Citation: Cardiovascular Diabetology 2017 16:153

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