Articles

Heterogeneity of antidiabetic treatment effect on the risk of major adverse cardiovascular events in type 2 diabetes: a systematic review and meta-analysis

We explored whether clinically relevant baseline characteristics of patients with type 2 diabetes can modify the effect of glucagon-like peptide-1 receptor agonists (GLP-1 RA) or sodium-glucose cotransporter-2...

Authors: Elvira D’Andrea, Aaron S. Kesselheim, Jessica M. Franklin, Emily H. Jung, Spencer Phillips Hey and Elisabetta Patorno

Exposure-weighted scoring for metabolic syndrome and the risk of myocardial infarction and stroke: a nationwide population-based study

Metabolic syndrome (MetS) status changes over time, but few studies have investigated the relationship between the extent or duration of exposure to MetS and the risk of cardiovascular disease (CVD). We invest...

Authors: Eun Young Lee, Kyungdo Han, Da Hye Kim, Yong-Moon Park, Hyuk-Sang Kwon, Kun-Ho Yoon, Mee Kyoung Kim and Seung-Hwan Lee

Long-term prognostic utility of low-density lipoprotein (LDL) triglyceride in real-world patients with coronary artery disease and diabetes or prediabetes

Recent guidelines highlighted the association between atherosclerosis and triglyceride-enriched lipoproteins in patients with impaired glucose metabolism. However, evidence from prospective studies for long-te...

Authors: Jing-Lu Jin, Hui-Wen Zhang, Ye-Xuan Cao, Hui-Hui Liu, Qi Hua, Yan-Fang Li, Yan Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Rui-Xia Xu, Ying Gao, Xiao-Lin Li, Chuan-Jue Cui, Geng Liu, Jing Sun…

Diabetes as a risk factor for incident peripheral arterial disease in women compared to men: a systematic review and meta-analysis

Previous meta-analyses have suggested that diabetes confers a greater excess risk of coronary heart disease, stroke, vascular dementia, and heart failure in women compared to men. While the underlying mechanis...

Authors: Alyssa Z. Chase-Vilchez, Isaac H. Y. Chan, Sanne A. E. Peters and Mark Woodward

Metformin may adversely affect orthostatic blood pressure recovery in patients with type 2 diabetes: substudy from the placebo-controlled Copenhagen Insulin and Metformin Therapy (CIMT) trial

Metformin has been shown to have both neuroprotective and neurodegenerative effects. The aim of this study was to investigate the effect of metformin in combination with insulin on cardiovascular autonomic neu...

Authors: Christian Stevns Hansen, Louise Lundby-Christiansen, Lise Tarnow, Christian Gluud, Christoffer Hedetoft, Birger Thorsteinsson, Bianca Hemmingsen, Niels Wiinberg, Simone B. Sneppen, Søren S. Lund, Thure Krarup, Sten Madsbad, Thomas Almdal, Bendix Carstensen and Marit E. Jørgensen

Combination therapy with pemafibrate (K-877) and pitavastatin improves vascular endothelial dysfunction in dahl/salt-sensitive rats fed a high-salt and high-fat diet

Statins suppress the progression of atherosclerosis by reducing low-density lipoprotein (LDL) cholesterol levels. Pemafibrate (K-877), a novel selective peroxisome proliferator-activated receptor α modulator, ...

Authors: Masatoki Yoshida, Kazufumi Nakamura, Toru Miyoshi, Masashi Yoshida, Megumi Kondo, Kaoru Akazawa, Tomonari Kimura, Hiroaki Ohtsuka, Yuko Ohno, Daiji Miura and Hiroshi Ito

Effects of empagliflozin versus placebo on cardiac sympathetic activity in acute myocardial infarction patients with type 2 diabetes mellitus: the EMBODY trial

Protection from lethal ventricular arrhythmias leading to sudden cardiac death (SCD) is a crucial challenge after acute myocardial infarction (AMI). Cardiac sympathetic and parasympathetic activity can be noni...

Authors: Wataru Shimizu, Yoshiaki Kubota, Yu Hoshika, Kosuke Mozawa, Shuhei Tara, Yukichi Tokita, Kenji Yodogawa, Yu-ki Iwasaki, Takeshi Yamamoto, Hitoshi Takano, Yayoi Tsukada, Kuniya Asai, Masaaki Miyamoto, Yasushi Miyauchi, Eitaro Kodani, Masahiro Ishikawa…

Sortilin levels correlate with major cardiovascular events of diabetic patients with peripheral artery disease following revascularization: a prospective study

Peripheral artery disease (PAD) represents one of the most relevant vascular complications of type 2 diabetes mellitus (T2DM). Moreover, T2DM patients suffering from PAD have an increased risk of major adverse...

Authors: Federico Biscetti, Elisabetta Nardella, Maria Margherita Rando, Andrea Leonardo Cecchini, Nicola Bonadia, Piergiorgio Bruno, Flavia Angelini, Carmine Di Stasi, Andrea Contegiacomo, Angelo Santoliquido, Dario Pitocco, Raffaele Landolfi and Andrea Flex

Impact of long-term glucose variability on coronary atherosclerosis progression in patients with type 2 diabetes: a 2.3 year follow-up study

Glycemic variability (GV) confers a risk of cardiovascular events. In this study, we aimed to investigate whether long-term GV has an impact on coronary atherosclerosis progression in patients with type 2 diab...

Authors: Suhua Li, Xixiang Tang, Yanting Luo, Bingyuan Wu, Zhuoshan Huang, Zexiong Li, Long Peng, Yesheng Ling, Jieming Zhu, Junlin Zhong, Jinlai Liu and Yanming Chen

Association of glucose uptake of visceral fat and acute myocardial infarction: a pilot ¹⁸F-FDG PET/CT study

Inflamed visceral adipose tissue (VAT) facilitates chronic inflammation in atherosclerotic lesions thereby leading to increased risk of coronary artery disease (CAD). In this study, we evaluated the glucose up...

Authors: Kisoo Pahk, Eung Ju Kim, Chanmin Joung, Hong Seog Seo and Sungeun Kim

Glucose variability and the risks of stroke, myocardial infarction, and all-cause mortality in individuals with diabetes: retrospective cohort study

Previous research regarding long-term glucose variability over several years which is an emerging indicator of glycemic control in diabetes showed several limitations. We investigated whether variability in lo...

Authors: Da Young Lee, Kyungdo Han, Sanghyun Park, Ji Hee Yu, Ji A. Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park and Nan Hee Kim

Arterial stiffness is an independent predictor for risk of mortality in patients with type 2 diabetes mellitus: the REBOUND study

This study aimed to evaluate the benefit of brachial-ankle pulse wave velocity (baPWV) as a noninvasive marker of arterial stiffness for the prediction of all-cause and cause-specific mortality in patients wit...

Authors: Jeong Mi Kim, Sang Soo Kim, In Joo Kim, Jong Ho Kim, Bo Hyun Kim, Mi Kyung Kim, Soon Hee Lee, Chang Won Lee, Min Chul Kim, Jun Hyeob Ahn and Jinmi Kim

Type 2 diabetes is an independent predictor of lowered peak aerobic capacity in heart failure patients with non-reduced or reduced left ventricular ejection fraction

Although type 2 diabetes mellitus (T2DM) is one of the most frequent comorbidities in patients with chronic heart failure (CHF), the effects of T2DM on the exercise capacity of CHF patients are fully unknown. ...

Authors: Takahiro Abe, Takashi Yokota, Arata Fukushima, Naoya Kakutani, Takashi Katayama, Ryosuke Shirakawa, Satoshi Maekawa, Hideo Nambu, Yoshikuni Obata, Katsuma Yamanashi, Ippei Nakano, Shingo Takada, Isao Yokota, Koichi Okita, Shintaro Kinugawa and Toshihisa Anzai

Does acute treatment of dapagliflozin reduce cardiac infarct size through direct cardiac effects or reductions in blood glucose levels?

Authors: Coert J. Zuurbier

Circulating Receptor Activator of Nuclear Factor kB Ligand and triglycerides are associated with progression of lower limb arterial calcification in type 2 diabetes: a prospective, observational cohort study

Lower limb arterial calcification is a frequent, underestimated but serious complication of diabetes. The DIACART study is a prospective cohort study designed to evaluate the determinants of the progression of...

Authors: Olivier Bourron, Franck Phan, Mamadou Hassimiou Diallo, David Hajage, Carole-Elodie Aubert, Aurélie Carlier, Joe-Elie Salem, Christian Funck-Brentano, Salim Kemel, Philippe Cluzel, Alban Redheuil, Jean-Michel Davaine, Ziad Massy, Romuald Mentaverri, Dominique Bonnefont-Rousselot, Philippe Gillery…

Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study

Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stif...

Authors: Minghui Li, Aihua Zhan, Xiao Huang, Lihua Hu, Wei Zhou, Tao Wang, Lingjuan Zhu, Huihui Bao and Xiaoshu Cheng

Long-term trajectories of BMI predict carotid stiffness and plaque volume in type 2 diabetes older adults: a cohort study

High body mass index (BMI) is a risk factor for type 2 diabetes and cardiovascular disease. However, its relationships with indices of carotid stiffness and plaque volume are unclear. We investigated associati...

Authors: Chen Botvin Moshe, Salo Haratz, Ramit Ravona-Springer, Anthony Heymann, Lin Hung-Mo, Michal Schnaider Beeri and David Tanne

Triglyceride glucose index for the detection of asymptomatic coronary artery stenosis in patients with type 2 diabetes

Triglyceride Glucose (TyG) index has been associated with an increased risk in cardiovascular events. Silent coronary disease is common in patients with type 2 diabetes. In Vietnam, a low-middle income country...

Authors: Pham Viet Thai, Hoang Anh Tien, Huynh Van Minh and Paul Valensi

MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy

The endothelium plays a pivotal role in maintaining vascular health. Obesity is a global epidemic that has seen dramatic increases in both adult and pediatric populations. Obesity perturbs the integrity of nor...

Authors: Karima Ait-Aissa, Quynh My Nguyen, Mohanad Gabani, Adam Kassan, Santosh Kumar, Soo-Kyoung Choi, Alexis A. Gonzalez, Tahsin Khataei, Amal M. Sahyoun, Cheng Chen and Modar Kassan

Macrophage accumulation within coronary arterial wall in diabetic patients with acute coronary syndrome: a study with in-vivo intravascular imaging modalities

Macrophage accumulation in arteriosclerotic plaque of coronary arteries is involved in plaque destabilization. Atherosclerosis has been known to be progressive in patients with type 2 diabetes mellitus (DM). T...

Authors: Takaaki Kogo, Takafumi Hiro, Daisuke Kitano, Tadateru Takayama, Daisuke Fukamachi, Tomoyuki Morikawa, Mitsumasa Sudo and Yasuo Okumura

Type 2 diabetes and reduced exercise tolerance: a review of the literature through an integrated physiology approach

The association between type 2 diabetes mellitus (T2DM) and heart failure (HF) is well established. Early in the course of the diabetic disease, some degree of impaired exercise capacity (a powerful marker of ...

Authors: Lorenzo Nesti, Nicola Riccardo Pugliese, Paolo Sciuto and Andrea Natali

Visit-to-visit HbA_1c variability is associated with in-stent restenosis in patients with type 2 diabetes after percutaneous coronary intervention

Patients with type 2 diabetes are under substantially higher risk of in-stent restenosis (ISR) after coronary stent implantation. We sought to investigate whether visit-to-visit HbA_1c variability is a potential p...

Authors: Chen Die Yang, Ying Shen, Lin Lu, Zhen Kun Yang, Jian Hu, Rui Yan Zhang, Wei Feng Shen, Feng Hua Ding and Xiao Qun Wang

Clinical application of sodium-glucose cotransporter 2 inhibitor into a real-world setting of heart failure care

For years there have been concerns whether the results of large-scale clinical trials that include limited specific patient populations can be applied to patients in real-world clinical practice. Therefore, it...

Authors: Atsushi Tanaka and Koichi Node

Visit-to-visit fasting plasma glucose variability is associated with left ventricular adverse remodeling in diabetic patients with STEMI

Patients with type 2 diabetes mellitus (T2DM) are predisposed to poor cardiovascular outcomes after ST-segment elevation myocardial infarction (STEMI). Left ventricular adverse remodeling (LVAR) triggered upon...

Authors: Chen Die Yang, Ying Shen, Feng Hua Ding, Zhen Kun Yang, Jian Hu, Wei Feng Shen, Rui Yan Zhang, Lin Lu and Xiao Qun Wang

SGLT2 inhibitors and atrial fibrillation in type 2 diabetes: a systematic review with meta-analysis of 16 randomized controlled trials

Type 2 diabetes is closely related to an increased risk of atrial fibrillation (AF) and atrial flutter (AFL). Whether sodium-glucose cotransporter 2 (SGLT2) inhibitors can attenuate AF/AFL progression remains ...

Authors: Wen-jie Li, Xing-qing Chen, Ling-ling Xu, Yuan-qing Li and Bi-hui Luo

Pericardial fat and its influence on cardiac diastolic function

Pericardial fat (PF) has been suggested to directly act on cardiomyocytes, leading to diastolic dysfunction. The aim of this study was to investigate whether a higher PF volume is associated with a lower diast...

Authors: Vera H. W. de Wit-Verheggen, Sibel Altintas, Romy J. M. Spee, Casper Mihl, Sander M. J. van Kuijk, Joachim E. Wildberger, Vera B. Schrauwen-Hinderling, Bas L. J. H. Kietselaer and Tineke van de Weijer

Efficacy and safety of bempedoic acid for prevention of cardiovascular events and diabetes: a systematic review and meta-analysis

Bempedoic acid is an oral, once-daily, first-in-class drug being developed for the treatment of hyperlipidemia. However, evidence of bempedoic acid use for the prevention of cardiovascular events and diabetes ...

Authors: Xing Wang, Yu Zhang, Huiwen Tan, Peng Wang, Xi Zha, Weelic Chong, Liangxue Zhou and Fang Fang

Omega-3 polyunsaturated fatty acid supplementation versus placebo on vascular health, glycaemic control, and metabolic parameters in people with type 1 diabetes: a randomised controlled preliminary trial

The role of omega-3 polyunsaturated fatty acids (n-3PUFA), and the potential impact of n-3PUFA supplementation, in the treatment and management of type 1 diabetes (T1D) remains unclear and controversial. There...

Authors: Lauren L. O’Mahoney, Gareth Dunseath, Rachel Churm, Mel Holmes, Christine Boesch, Antonios Stavropoulos-Kalinoglou, Ramzi A. Ajjan, Karen M. Birch, Nicolas M. Orsi, Georgia Mappa, Oliver J. Price and Matthew D. Campbell

Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles

Lipoprotein disturbances have been associated with increased cardiovascular disease (CVD) risk in type 1 diabetes mellitus (T1DM). We assessed the advanced lipoprotein profile in T1DM individuals, and analysed...

Authors: Antonio J. Amor, Esmeralda Castelblanco, Marta Hernández, Marga Gimenez, Minerva Granado-Casas, Jesús Blanco, Berta Soldevila, Enric Esmatjes, Ignacio Conget, Nuria Alonso, Emilio Ortega and Didac Mauricio

Elevated levels of adiponectin associated with major adverse cardiovascular and cerebrovascular events and mortality risk in ischemic stroke

Adiponectin plays role in multiple metabolic pathways. Previous studies in cardiovascular disease evaluated the association between adiponectin and clinical outcomes, yielding conflicting results. The aim of t...

Authors: Wen-Jun Tu, Han-Cheng Qiu, Ya-Kun Liu, Qiang Liu, Xianwei Zeng and Jizong Zhao

Metformin treatment in heart failure with preserved ejection fraction: a systematic review and meta-regression analysis

Observational series suggest a mortality benefit from metformin in the heart failure (HF) population. However, the benefit of metformin in HF with preserved ejection fraction (HFpEF) has yet to be explored. We...

Authors: Amera Halabi, Jonathan Sen, Quan Huynh and Thomas H. Marwick

Ferritin modifies the relationship between inflammation and arterial stiffness in hypertensive patients with different glucose tolerance

Ferritin, a crucial element for iron homeostasis, is associated with chronic diseases characterized by subclinical inflammation such as essential arterial hypertension and type 2 diabetes mellitus (T2DM), show...

Authors: Angela Sciacqua, Ettore Ventura, Giovanni Tripepi, Velia Cassano, Graziella D’Arrigo, Stefanos Roumeliotis, Raffale Maio, Sofia Miceli, Maria Perticone, Francesco Andreozzi, Giorgio Sesti and Francesco Perticone

Patients with type 2 diabetes present with multiple anomalies of the pancreatic arterial tree on abdominal computed tomography: comparison between patients with type 2 diabetes and a matched control group

Studies suggest that cardio-vascular risk factors could foster the development of type 2 diabetes (T2D). This could partly be mediated by pancreatic atherosclerosis resulting in pancreatic ischemia. We hypothe...

Authors: Laure Alexandre-Heymann, Matthias Barral, Anthony Dohan and Etienne Larger

Predictive values of ANGPTL8 on risk of all-cause mortality in diabetic patients: results from the REACTION Study

Angiopoietin-like protein 8 (ANGPTL8), an important regulator of lipid metabolism, is increased in diabetes and is associated with insulin resistance. However, the role of ANGPTL8 in the outcomes of diabetic p...

Authors: Huajie Zou, Yongping Xu, Xi Chen, Ping Yin, Danpei Li, Wenjun Li, Junhui Xie, Shiying Shao, Liegang Liu and Xuefeng Yu

Growth differentiation factor-15 is associated with cardiovascular outcomes in patients with coronary artery disease

Growth differentiation factor-15 (GDF-15) is a marker of inflammation, oxidative stress and it is associated with adverse prognosis in cardiovascular disease. The aim of the present cohort study is to investig...

Authors: Man Li, Lei Duan, Yu-Lun Cai, Hui-Ying Li, Ben-Chuan Hao, Jian-Qiao Chen and Hong-Bin Liu

Long term clinical impact of successful recanalization of chronic total occlusion in patients with and without type 2 diabetes mellitus

Diabetes mellitus is one of the risk factors for coronary artery disease and frequently associated with multivessels disease and poor clinical outcomes. Long term outcome of successful revascularization of chr...

Authors: Chuan-Tsai Tsai, Wei-Chieh Huang, Hsin-I Teng, Yi-Lin Tsai and Tse-Min Lu

Associations between abdominal obesity indices and diabetic complications: Chinese visceral adiposity index and neck circumference

Obesity, especially abdominal obesity, has been considered a risk factor for diabetic complications. Many abdominal obesity indices have been established, including neck circumference (NC), waist-to-hip ratio ...

Authors: Heng Wan, Yuying Wang, Qian Xiang, Sijie Fang, Yi Chen, Chi Chen, Wen Zhang, Haojie Zhang, Fangzhen Xia, Ningjian Wang and Yingli Lu

The adipokine fatty-acid binding protein 4 and cardiac remodeling

Previous publications about the association between fatty-acid binding protein 4 (FABP4) and cardiac remodeling have reported different, both beneficial and harmful, associations. Aim of the present investigat...

Authors: Beatrice von Jeinsen, Lisa Ritzen, Julia Vietheer, Claudia Unbehaun, Maren Weferling, Christoph Liebetrau, Christian W. Hamm, Andreas Rolf and Till Keller

Discordance between the triglyceride glucose index and fasting plasma glucose or HbA1C in patients with acute coronary syndrome undergoing percutaneous coronary intervention predicts cardiovascular events: a cohort study from China

Previous studies have investigated the relationship of the triglyceride glucose (TyG) index with the incidence of cardiovascular events. However, to date, there have been no studies comparing the predictive va...

Authors: Chengping Hu, Jianwei Zhang, Jinxing Liu, Yan Liu, Ang Gao, Yong Zhu and Yingxin Zhao

Treating type 2 diabetes in COVID-19 patients: the potential benefits of injective therapies

The coronavirus disease 2019 (COVID-19) has been declared as pandemic by the World Health Organization and is causing substantial morbidity and mortality all over the world. Type 2 diabetes, hypertension, and ...

Authors: Miriam Longo, Paola Caruso, Maria Ida Maiorino, Giuseppe Bellastella, Dario Giugliano and Katherine Esposito

Issues for the management of people with diabetes and COVID-19 in ICU

In the pandemic “Corona Virus Disease 2019” (COVID-19) people with diabetes have a high risk to require ICU admission. The management of diabetes in Intensive Care Unit is always challenging, however, when dia...

Authors: Antonio Ceriello, Eberhard Standl, Doina Catrinoiu, Baruch Itzhak, Nebojsa M. Lalic, Dario Rahelic, Oliver Schnell, Jan Škrha and Paul Valensi

Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry

The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using s...

Authors: Ki-Bum Won, Byoung Kwon Lee, Hyung-Bok Park, Ran Heo, Sang-Eun Lee, Asim Rizvi, Fay Y. Lin, Amit Kumar, Martin Hadamitzky, Yong-Jin Kim, Ji Min Sung, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J. Budoff, Ilan Gottlieb…

A high triglyceride glucose index is more closely associated with hypertension than lipid or glycemic parameters in elderly individuals: a cross-sectional survey from the Reaction Study

Both lipid and glucose abnormalities are associated with hypertension (HTN). However, it is unclear whether the triglyceride-glucose (TyG) index is associated with HTN. Therefore the aim of this study is to in...

Authors: Binruo Zhu, Jie Wang, Kang Chen, Wenhua Yan, Anping Wang, Weiqing Wang, Zhengnan Gao, Xulei Tang, Li Yan, Qin Wan, Zuojie Luo, Guijun Qin, Lulu Chen and Yiming Mu

Lipoprotein (a) predicts recurrent worse outcomes in type 2 diabetes mellitus patients with prior cardiovascular events: a prospective, observational cohort study

Merging studies have reported the association of lipoprotein(a) [Lp(a)] with poor outcomes of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). However, the prognostic importance ...

Authors: Yan Zhang, Jing-Lu Jin, Ye-Xuan Cao, Hui-Wen Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Ying Gao, Qi Hua, Yan-Fang Li, Rui-Xia Xu and Jian-Jun Li

Tofogliflozin does not delay progression of carotid atherosclerosis in patients with type 2 diabetes: a prospective, randomized, open-label, parallel-group comparative study

This study aimed to investigate the preventive effects of tofogliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, on atherosclerosis progression in type 2 diabetes (T2DM) patients without ...

Authors: Naoto Katakami, Tomoya Mita, Hidenori Yoshii, Toshihiko Shiraiwa, Tetsuyuki Yasuda, Yosuke Okada, Keiichi Torimoto, Yutaka Umayahara, Hideaki Kaneto, Takeshi Osonoi, Tsunehiko Yamamoto, Nobuichi Kuribayashi, Kazuhisa Maeda, Hiroki Yokoyama, Keisuke Kosugi, Kentaro Ohtoshi…

The association between glucose-related variables and plaque morphology in patients with ST-segment elevated myocardial infarction

Plaque rupture (PR) and plaque erosion (PE) are main causes of acute myocardial infarction with different demographic and histology characteristics and need different treatment strategy. PR and PE can be ident...

Authors: Jinxin Liu, Shanjie Wang, Can Cui, Hengxuan Cai, Rong Sun, Weili Pan, Shaohong Fang and Bo Yu

Impacts of triglyceride-glucose index on prognosis of patients with type 2 diabetes mellitus and non-ST-segment elevation acute coronary syndrome: results from an observational cohort study in China

The relationship between triglyceride-glucose index (TyG index) and the prevalence and prognosis of cardiovascular disease has been confirmed by former studies. However, it remains uncertain whether TyG index ...

Authors: Qi Zhao, Ting-Yu Zhang, Yu-Jing Cheng, Yue Ma, Ying-Kai Xu, Jia-Qi Yang and Yu-Jie Zhou

Add-on therapy in metformin-treated patients with type 2 diabetes at moderate cardiovascular risk: a nationwide study

In randomised clinical trials, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium–glucose cotransporter 2 (SGLT-2) inhibitors reduced cardiovascular events in patients with type 2 diabetes (T2D) ...

Authors: David Thein, Mia Nielsen Christiansen, Ulrik Madvig Mogensen, Johan Skov Bundgaard, Rasmus Rørth, Christian Madelaire, Emil Loldrup Fosbøl, Morten Schou, Christian Torp-Pedersen, Gunnar Gislason, Lars Køber and Søren Lund Kristensen

Liraglutide in the treatment of heart failure: insight from FIGHT and LIVE

There are many glucose-lowering agents used in patients with heart failure, showing mixed results, this study was conducted to determine the effect of liraglutide, a glucagon-like peptide-1 analogue, on the tr...

Authors: Bo Liang and Ning Gu

Comparative predictive ability of visit-to-visit HbA1c variability measures for microvascular disease risk in type 2 diabetes

To assess the associations of various HbA1c measures, including a single baseline HbA1c value, overall mean, yearly updated means, standard deviation (HbA1c-SD), coefficient of variation (HbA1c-CV), and HbA1c ...

Authors: Chen-Yi Yang, Pei-Fang Su, Jo-Ying Hung, Huang-Tz Ou and Shihchen Kuo