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  1. Endothelial dysfunction precedes pathogenesis of vascular complications in diabetes. In recent years, the mechanisms of endothelial dysfunction were investigated to outline strategies for its treatment. Howeve...

    Authors: Hemang Patel, Juan Chen, Kumuda C Das and Mahendra Kavdia
    Citation: Cardiovascular Diabetology 2013 12:142
  2. Accumulation of advanced glycation end products (AGEs) in the vasculature triggers a series of morphological and functional changes contributing to endothelial hyperpermeability. The reorganisation and redistr...

    Authors: Zhenyu Li, Qiaoqing Zhong, Tianlun Yang, Xiumei Xie and Meifang Chen
    Citation: Cardiovascular Diabetology 2013 12:141
  3. It is a matter of debate whether metabolic syndrome (MS) improves cardiovascular risk prediction beyond the risk associated with its individual components. The present study examined the association of MS scor...

    Authors: Jong-Youn Kim, Eui-Young Choi, Hee-Sun Mun, Pil-Ki Min, Young-Won Yoon, Byoung Kwon Lee, Bum-Kee Hong, Se-Joong Rim and Hyuck Moon Kwon
    Citation: Cardiovascular Diabetology 2013 12:140
  4. Development of a cardiomyopathy in diabetes mellitus is independent of traditional risk factors, with no clinical trials targeting specific therapeutic interventions. Myocardial fibrosis is one of the key mech...

    Authors: Melissa Leung, Vincent W Wong, Stephane Heritier, Anastasia S Mihailidou and Dominic Y Leung
    Citation: Cardiovascular Diabetology 2013 12:139
  5. Dyslipidemia, a major risk factor for cardiovascular disease is a common finding in patients with type 2 diabetes and among women with gestational diabetes. Elevated levels of lipoprotein(a) [Lp(a)] are linked...

    Authors: Jelena Todoric, Ammon Handisurya, Karoline Leitner, Juergen Harreiter, Gregor Hoermann and Alexandra Kautzky-Willer
    Citation: Cardiovascular Diabetology 2013 12:138
  6. A relationship between plasma adiponectin level and a number of metabolic conditions, including insulin resistance, obesity, and type 2 diabetes, has been reported. This study aimed to assess whether urinary a...

    Authors: Won Seon Jeon, Ji Woo Park, Namseok Lee, Se Eun Park, Eun Jung Rhee, Won Young Lee, Ki Won Oh, Sung Woo Park, Cheol-Young Park and Byung-Soo Youn
    Citation: Cardiovascular Diabetology 2013 12:137
  7. To study the pathogenesis of diabetic cardiomyopathy, reliable animal models of type 2 diabetes are required. Physiologically relevant rodent models are needed, which not only replicate the human pathology but...

    Authors: Latt S Mansor, Eileen R Gonzalez, Mark A Cole, Damian J Tyler, Jessica H Beeson, Kieran Clarke, Carolyn A Carr and Lisa C Heather
    Citation: Cardiovascular Diabetology 2013 12:136
  8. Increased levels of the sugar metabolite methylglyoxal (MG) in vivo were shown to participate in the pathophysiology of vascular complications in diabetes. Alterations of endothelial nitric oxide synthase (eNOS) ...

    Authors: Yang Su, Syed M Qadri, Lingyun Wu and Lixin Liu
    Citation: Cardiovascular Diabetology 2013 12:134
  9. Large body of evidences accumulated in clinical and epidemiological studies indicate that hearts of diabetic subjects are more sensitive to ischemia reperfusion injury (IRI), which results in a higher rate of ...

    Authors: Haobo Li, Zipeng Liu, Junwen Wang, Gordon T Wong, Chi-Wai Cheung, Liangqing Zhang, Can Chen, Zhengyuan Xia and Michael G Irwin
    Citation: Cardiovascular Diabetology 2013 12:133
  10. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) detoxifies reactive aldehydes in the micro- and macrovasculature. These substrates, including methylglyoxal and 4-hydroxynonenal formed from glucose and lipids, c...

    Authors: Kazunori Morita, Junji Saruwatari, Haruna Miyagawa, Yoshihiro Uchiyashiki, Kentaro Oniki, Misaki Sakata, Ayami Kajiwara, Akira Yoshida, Hideaki Jinnouchi and Kazuko Nakagawa
    Citation: Cardiovascular Diabetology 2013 12:132
  11. The Cardiovascular Risk Evaluation in people with type 2 Diabetes on Insulin Therapy (CREDIT) study is an international, multicenter, observational study designed to assess metabolic parameters and cardiovascu...

    Authors: Ryuzo Kawamori, Koichi Node, Toshiaki Hanafusa, Yoshihito Atsumi, Yusuke Naito and Yoshitomo Oka
    Citation: Cardiovascular Diabetology 2013 12:131
  12. Sulfonylureas (SUs) are commonly used in the treatment of type 2 diabetes (T2DM), usually as second-line treatment after the failure of metformin. However, SUs are associated with poor durability, hypoglycemia...

    Authors: Martin Ridderstråle, Robbyna Svaerd, Cordula Zeller, Gabriel Kim, Hans J Woerle and Uli C Broedl
    Citation: Cardiovascular Diabetology 2013 12:129
  13. This study aimed to evaluate the efficacy of mesenchymal stem cell (MSC) transplantation to mitigate abnormalities in cardiac-specific and systemic metabolism mediated by a combination of a myocardial infarcti...

    Authors: Curtis C Hughey, Lianli Ma, Freyja D James, Deanna P Bracy, Zhizhang Wang, David H Wasserman, Jeffrey N Rottman, Dustin S Hittel and Jane Shearer
    Citation: Cardiovascular Diabetology 2013 12:128
  14. Symptoms of heart failure with preserved left ventricular systolic function are common among patients undergoing peritoneal dialysis (PD). Epicardial fat (EpF) is an ectopic fat depot with possible paracrine o...

    Authors: Heng-Hsu Lin, Jen-Kuang Lee, Chung-Yi Yang, Yu-Chung Lien, Jenq-Wen Huang and Cho-Kai Wu
    Citation: Cardiovascular Diabetology 2013 12:127
  15. Novel and robust cardiovascular (CV) markers are needed to improve CV morbidity and mortality risk prediction in type 2 diabetes (T2D). We assessed the long term predictive value of 4 novel CV risk markers for...

    Authors: Anne Pernille Ofstad, Lars Gullestad, Elsa Orvik, Svend Aakhus, Knut Endresen, Thor Ueland, Pål Aukrust, Morten W Fagerland, Kåre I Birkeland and Odd Erik Johansen
    Citation: Cardiovascular Diabetology 2013 12:126
  16. Advanced glycation end products (AGEs) and receptor RAGE interaction play a role in diabetic vascular complications. Inhibition of dipeptidyl peptidase-4 (DPP-4) is a potential therapeutic target for type 2 di...

    Authors: Yuji Ishibashi, Takanori Matsui, Sayaka Maeda, Yuichiro Higashimoto and Sho-ichi Yamagishi
    Citation: Cardiovascular Diabetology 2013 12:125
  17. Expression and activity of the fibroblast growth factor (FGF) 21 hormone-like protein are associated with development of several metabolic disorders. This study was designed to investigate whether serum FGF21 ...

    Authors: Yun Shen, Xiaojing Ma, Jian Zhou, Xiaoping Pan, Yaping Hao, Mi Zhou, Zhigang Lu, Meifang Gao, Yuqian Bao and Weiping Jia
    Citation: Cardiovascular Diabetology 2013 12:124
  18. Intracellular calcium (Ca2+) coordinates the cardiac contraction cycle and is dysregulated in diabetic cardiomyopathy. Treatment with triethylenetetramine (TETA), a divalent-copper-selective chelator, improves ca...

    Authors: Lin Zhang, Marie-Louise Ward, Anthony RJ Phillips, Shaoping Zhang, John Kennedy, Bernard Barry, Mark B Cannell and Garth JS Cooper
    Citation: Cardiovascular Diabetology 2013 12:123
  19. Authors: Joris van Ark, Hans-Peter Hammes, Marcory CRF van Dijk, Chris PH Lexis, Iwan CC van der Horst, Clark J Zeebregts, Marc G Vervloet, Bruce HR Wolffenbuttel, Harry van Goor and Jan-Luuk Hillebrands
    Citation: Cardiovascular Diabetology 2013 12:120

    The original article was published in Cardiovascular Diabetology 2013 12:116

  20. Non-invasive measurements of 24 hour ambulatory central aortic systolic pressure (24 h-CASP) and central pulse pressure (24 h-CPP) are now feasible. We evaluate the relationship between 24 h central blood pres...

    Authors: Simone Theilade, Maria Lajer, Tine Willum Hansen, Christel Joergensen, Frederik Persson, Gudbjörg Andrésdottir, Henrik Reinhard, Stine Elkjær Nielsen, Peter Lacy, Bryan Williams and Peter Rossing
    Citation: Cardiovascular Diabetology 2013 12:122
  21. Cardiovascular risk stratification of asymptomatic diabetic patients is important and remains a difficult clinical problem. Our aim was to test the hypothesis that coronary flow reserve (CFR) assessed by nonin...

    Authors: Takayuki Kawata, Masao Daimon, Rei Hasegawa, Tomohiko Toyoda, Tai Sekine, Toshiharu Himi, Daigaku Uchida, Sakiko Miyazaki, Kuniaki Hirose, Ryoko Ichikawa, Masaki Maruyama, Hiromasa Suzuki and Hiroyuki Daida
    Citation: Cardiovascular Diabetology 2013 12:121
  22. Nicotinamide phosphoribosyltransferase (NAMPT) is the limiting enzyme in one of pathways of synthesis of Nicotinamide Adenine Dinucleotide, a redox coenzyme. NAMPT is considered as an insulin-mimetic factor an...

    Authors: Pedro Saddi-Rosa, Carolina Soares Oliveira, Felipe Crispim, Fernando MA Giuffrida, Valter Correia de Lima, José Gilberto Vieira, Alessandro Doria, Gilberto Velho and André Fernandes Reis
    Citation: Cardiovascular Diabetology 2013 12:119
  23. Limitations of the currently recommended stepwise treatment pathway for type 2 diabetes mellitus (T2DM), especially the failure of monotherapies to maintain good glycemic control, have prompted use of early, m...

    Authors: Li-Nong Ji, Chang-Yu Pan, Ju-Ming Lu, Hong Li, Qiang Li, Qi-Fu Li, Yong-De Peng, Hao-Ming Tian, Chen Yao, Zhi-Gang Zhao, Ru-Ya Zhang, Xiang-Ling Wang and Lei Wang
    Citation: Cardiovascular Diabetology 2013 12:118
  24. GLP-1 is an incretine hormone which gets secreted from intestinal L-cells in response to nutritional stimuli leading to pancreatic insulin secretion and suppression of glucagon release. GLP-1 further inhibits ...

    Authors: Katja Piotrowski, Melanie Becker, Julia Zugwurst, Ingeborg Biller-Friedmann, Gerald Spoettl, Martin Greif, Alexander W Leber, Alexander Becker, Rüdiger P Laubender, Corinna Lebherz, Burkhard Goeke, Nikolaus Marx, Klaus G Parhofer and Michael Lehrke
    Citation: Cardiovascular Diabetology 2013 12:117
  25. Diabetes is associated with a high incidence of macrovascular disease (MVD), including peripheral and coronary artery disease. Circulating soluble-Klotho (sKlotho) is produced in the kidney and is a putative a...

    Authors: Joris van Ark, Hans-Peter Hammes, Marcory C R F van Dijk, Marc G Vervloet, Bruce H R Wolffenbuttel, Harry van Goor and Jan-Luuk Hillebrands
    Citation: Cardiovascular Diabetology 2013 12:116

    The Erratum to this article has been published in Cardiovascular Diabetology 2013 12:120

  26. We used Laser Doppler Fluximetry (LDF) to define "normal" endothelial function in a large cohort of healthy children and adolescents and to evaluate skin microcirculation in paediatric patients with type 1 dia...

    Authors: Mirjam Heimhalt-El Hamriti, Corinna Schreiver, Anja Noerenberg, Julia Scheffler, Ulrike Jacoby, Dieter Haffner and Dagmar-C Fischer
    Citation: Cardiovascular Diabetology 2013 12:115
  27. Cardiac nestin(+) cells exhibit properties of a neural progenitor/stem cell population characterized by the de novo synthesis of neurofilament-M in response to ischemic injury and 6-hydroxydopamine administration...

    Authors: Andreanne Chabot, Marc-Andre Meus, Vanessa Hertig, Natacha Duquette and Angelino Calderone
    Citation: Cardiovascular Diabetology 2013 12:114
  28. Little or no research has determined the effect of vitamin D3 supplementation in conjunction with pharmacological and non-pharmacological approaches in the diabetes mellitus type 2 (DMT2) patients. The objecti...

    Authors: Khalid M Alkharfy, Nasser M Al-Daghri, Shaun B Sabico, Abdulaziz Al-Othman, Osama Moharram, Majed S Alokail, Yousef Al-Saleh, Sudhesh Kumar and George P Chrousos
    Citation: Cardiovascular Diabetology 2013 12:113
  29. Qualitative alterations of lipoproteins underlie the high incidence of atherosclerosis in diabetes. The objective of this study was to assess the impact of low-density lipoprotein (LDL) subfraction phenotype o...

    Authors: Jose Luis Sánchez-Quesada, Irene Vinagre, Elena De Juan-Franco, Juan Sánchez-Hernández, Rosa Bonet-Marques, Francisco Blanco-Vaca, Jordi Ordóñez-Llanos and Antonio Pérez
    Citation: Cardiovascular Diabetology 2013 12:112
  30. Activation of RhoA/Rho-kinase (ROCK) is increasingly implicated in acute vasospasm and chronic vasoconstriction in major organ systems. Therefore we aimed to ascertain whether an increase in ROCK activity play...

    Authors: James T Pearson, Mathew J Jenkins, Amanda J Edgley, Takashi Sonobe, Mandar Joshi, Mark T Waddingham, Yutaka Fujii, Daryl O Schwenke, Hirotsugu Tsuchimochi, Misa Yoshimoto, Keiji Umetani, Darren J Kelly and Mikiyasu Shirai
    Citation: Cardiovascular Diabetology 2013 12:111
  31. Low-grade albuminuria is associated with cardiovascular risk factors and mortality. Our aim was to investigate the association between low-grade albuminuria and carotid atherosclerotic lesions in community-bas...

    Authors: Mei-Fang Li, Yin-Fang Tu, Lian-Xi Li, Jun-Xi Lu, Xue-Hong Dong, Li-Bo Yu, Rong Zhang, Yu-Qian Bao, Wei-Ping Jia and Ren-Ming Hu
    Citation: Cardiovascular Diabetology 2013 12:110
  32. Left ventricular hypertrophy has multiple aetiologies including diabetes and genetic factors. We aimed to identify genetic variants predicting left ventricular hypertrophy in diabetic individuals.

    Authors: Helen M Parry, Louise A Donnelly, Natalie Van Zuydam, Alexander SF Doney, Douglas HJ Elder, Andrew D Morris, Alan D Struthers, Colin NA Palmer and Chim C Lang
    Citation: Cardiovascular Diabetology 2013 12:109
  33. Circulatory and tissue renin-angiotensin systems (RAS) play a central role in cardiovascular (CV) and renal pathophysiology, making RAS inhibition a logical therapeutic approach in the prevention of CV and ren...

    Authors: Samir G Mallat
    Citation: Cardiovascular Diabetology 2013 12:108
  34. The arterial system in diabetic patients is characterized by generalized non-atherosclerotic alterations in the vascular extracellular matrix causing increased arterial stiffness compared with subjects without...

    Authors: Esben Laugesen, Pernille Høyem, Jens Sandahl Christiansen, Søren Tang Knudsen, Klavs Würgler Hansen, W Scott Argraves, Troels Krarup Hansen, Per Løgstrup Poulsen and Lars Melholt Rasmussen
    Citation: Cardiovascular Diabetology 2013 12:107
  35. Insulin resistance (IR) is the key feature of the metabolic syndrome (MetS); its association with peripheral arterial disease (PAD) is unclear. We hypothesized that IR is associated with both the MetS and sono...

    Authors: Alexander Vonbank, Christoph H Saely, Philipp Rein and Heinz Drexel
    Citation: Cardiovascular Diabetology 2013 12:106
  36. Adipokines, including adipocyte fatty acid-binding protein (A-FABP), have been demonstrated to be involved in the pathogenesis of atherosclerosis. In the present study, we investigated the association of circu...

    Authors: Chi-Lun Huang, Yen-Wen Wu, Chih-Cheng Wu, Lin Lin, Yu-Chin Wu, Pei-Ying Hsu, Yuh-Shiun Jong and Wei-Shiung Yang
    Citation: Cardiovascular Diabetology 2013 12:105
  37. Dyslipidemia is a common complication in patients with diabetes and is involved in being prone to cardiovascular disease. The risk of coronary artery disease is known to be lower in light-to-moderate drinkers ...

    Authors: Tomoko Shimomura and Ichiro Wakabayashi
    Citation: Cardiovascular Diabetology 2013 12:104
  38. Genetic variants of the FTO gene rs9939609 A/T and the MC4R gene rs17782313 C/T have been associated with obesity. Individuals with mutations in MC4R gene have lower blood pressure (BP), independently of obesity....

    Authors: Aline Marcadenti, Flavio D Fuchs, Ursula Matte, Fernanda Sperb, Leila B Moreira and Sandra C Fuchs
    Citation: Cardiovascular Diabetology 2013 12:103
  39. Patients with type 2 diabetes are at increased risk for both, left ventricular (LV)-dilatation and myocardial infarction (MI) following the rupture of a vulnerable plaque. This study investigated the to date i...

    Authors: Mathias Burgmaier, Michael Frick, Ana Liberman, Simone Battermann, Martin Hellmich, Walter Lehmacher, Agnes Jaskolka, Nikolaus Marx and Sebastian Reith
    Citation: Cardiovascular Diabetology 2013 12:102
  40. Exercise causes physiological cardiac hypertrophy and benefits the diabetic heart. Mammalian switch-independent 3A (mSin3A) and histone deacetylases (HDACs) 1 and 2 regulate hypertrophic genes through associat...

    Authors: Emily J Cox and Susan A Marsh
    Citation: Cardiovascular Diabetology 2013 12:101
  41. Icosapent ethyl (IPE) is a high-purity prescription form of eicosapentaenoic acid (EPA) ethyl ester indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe (≥500 mg/dL)...

    Authors: Eliot A Brinton, Christie M Ballantyne, Harold E Bays, John J Kastelein, Rene A Braeckman and Paresh N Soni
    Citation: Cardiovascular Diabetology 2013 12:100
  42. Glucose intolerance and cardiovascular complications are major symptoms in patients with diabetes. Many therapies have proven beneficial in treating diabetes in animals by protecting the cardiovascular system ...

    Authors: Yi-Jin Ho, Wen-Pin Chen, Tzong-Cherng Chi, Ching-Chia Chang Chien, An-Sheng Lee, Hsi-Lin Chiu, Yueh-Hsiung Kuo and Ming-Jai Su
    Citation: Cardiovascular Diabetology 2013 12:99
  43. Previous reports have clearly indicated a significant relationship between hemoglobin (Hb) A1c change from one visit to the next and microvascular complications, especially nephropathy (albuminuria and albuminuri...

    Authors: Giuseppe Penno, Anna Solini, Giacomo Zoppini, Emanuela Orsi, Cecilia Fondelli, Gianpaolo Zerbini, Susanna Morano, Franco Cavalot, Olga Lamacchia, Roberto Trevisan, Monica Vedovato and Giuseppe Pugliese
    Citation: Cardiovascular Diabetology 2013 12:98
  44. It has been reported that hyperglycemia following hypoglycemia produces an ischemia-reperfusion-like effect in type 1 diabetes. In this study the possibility that GLP-1 has a protective effect on this phenomen...

    Authors: Antonio Ceriello, Anna Novials, Emilio Ortega, Silvia Canivell, Gemma Pujadas, Lucia La Sala, Loredana Bucciarelli, Maurizio Rondinelli and Stefano Genovese
    Citation: Cardiovascular Diabetology 2013 12:97
  45. Glycemic memory of endothelial cells is an effect of long-lasting hyperglycemia and is a cause of various diabetics complications, that arises despite of the treatment targeted towards returning low glucose le...

    Authors: Marta Targosz-Korecka, Grzegorz D Brzezinka, Katarzyna E Malek, Ewa Stȩpień and Marek Szymonski
    Citation: Cardiovascular Diabetology 2013 12:96
  46. Patients with type 2 diabetes (T2D) are at elevated risk for cardiovascular disease (CVD) events and mortality. Recent studies have assessed the impact of genetic variants affecting high-density lipoprotein ch...

    Authors: Laura M Raffield, Amanda J Cox, Fang-Chi Hsu, Maggie C-Y Ng, Carl D Langefeld, J Jeffrey Carr, Barry I Freedman and Donald W Bowden
    Citation: Cardiovascular Diabetology 2013 12:95
  47. Type 2 diabetes mellitus (T2DM) is associated with subclinical myocardial injury although the underlying mechanism is uncertain. We postulated that arterial stiffness, endothelial dysfunction and subclinical a...

    Authors: Kai-Hang Yiu, Chun-Ting Zhao, Yan Chen, Chung-Wah Siu, Yap-Hang Chan, Kui-Kai Lau, Shasha Liu, Chu-Pak Lau and Hung-Fat Tse
    Citation: Cardiovascular Diabetology 2013 12:94
  48. Increased arterial stiffness is a cardiovascular outcome of metabolic syndrome (MetS). The chromosome 9p21 locus has been identified as a major locus for risk of coronary artery disease (CAD). The single nucle...

    Authors: Suphawadee Phababpha, Upa Kukongviriyapan, Poungrat Pakdeechote, Laddawan Senggunprai, Veerapol Kukongviriyapan, Chatri Settasatian, Pyatat Tatsanavivat, Phongsak Intharaphet, Vichai Senthong, Nantarat Komanasin, Nongnuch Settasatian and Stephen E Greenwald
    Citation: Cardiovascular Diabetology 2013 12:93

Cardiovascular Diabetology is affiliated with Sackler Faculty of Medicine, Tel-Aviv University

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