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  1. The aim of this study is to evaluate the effect of gender and menopause in cardiometabolic risk in a type 2 diabetes mellitus (T2DM) population, based on classical and non-traditional markers.

    Authors: Filipa Mascarenhas-Melo, Daniela Marado, Filipe Palavra, José Sereno, Álvaro Coelho, Rui Pinto, Edite Teixeira-Lemos, Frederico Teixeira and Flávio Reis
    Citation: Cardiovascular Diabetology 2013 12:61
    Content type: Original investigation Published on:

  2. In patients with type 2 diabetes mellitus (T2DM), hypertension and microalbuminuria are predictive markers for increased renal and cardiovascular risk. This post hoc analysis of data from a global development pro...

    Authors: Maximilian von Eynatten, Yan Gong, Angela Emser and Hans-Juergen Woerle
    Citation: Cardiovascular Diabetology 2013 12:60
    Content type: Original investigation Published on:

  3. Numerous rheological and microvascular alterations characterize the vascular pathology in patients with type 2 diabetes mellitus (T2DM). This study investigated effects of vildagliptin in comparison to glimepi...

    Authors: Christine Berndt-Zipfel, Georg Michelson, Markus Dworak, Michael Mitry, Andrea Löffler, Andreas Pfützner and Thomas Forst
    Citation: Cardiovascular Diabetology 2013 12:59
    Content type: Original investigation Published on:

  4. Insulin resistance is strongly associated with the development of type 2 diabetes and cardiovascular disease. However, the underlying mechanisms linking insulin resistance and the development of atherosclerosi...

    Authors: Jianxin Lu, Jingzhang Ji, Howard Meng, David Wang, Bo Jiang, Lixin Liu, Edward Randell, Khosrow Adeli and Qing H Meng
    Citation: Cardiovascular Diabetology 2013 12:58
    Content type: Original investigation Published on:

  5. Pigment epithelium-derived factor (PEDF) has been proved to be closely correlated with metabolic syndrome (MetS) and its components that are all risk factors of cardiovascular disease and may play a protective...

    Authors: Feifei Wang, Xiaojing Ma, Mi Zhou, Xiaoping Pan, Jie Ni, Meifang Gao, Zhigang Lu, Jingyu Hang, Yuqian Bao and Weiping Jia
    Citation: Cardiovascular Diabetology 2013 12:56
    Content type: Original investigation Published on:

  6. Anthropometric measurements are useful in clinical practice since they are non-invasive and cheap. Previous studies suggest that sagittal abdominal diameter (SAD) may be a better measure of visceral fat depots...

    Authors: Elsa M Dahlén, Niclas Bjarnegård, Toste Länne, Fredrik H Nystrom and Carl J Östgren
    Citation: Cardiovascular Diabetology 2013 12:55
    Content type: Original investigation Published on:

  7. Cardiovascular diseases remain a leading cause of the mortality world-wide, which is related to several risks, including the life style change and the increased diabetes prevalence. The present study was to ex...

    Authors: Xiao Miao, Yonggang Wang, Jian Sun, Weixia Sun, Yi Tan, Lu Cai, Yang Zheng, Guanfang Su, Quan Liu and Yuehui Wang
    Citation: Cardiovascular Diabetology 2013 12:54
    Content type: Original investigation Published on:

  8. Chronic treatment with currently available oral hypoglyemic medications may result in a differential effect on the clinical presentation of diabetic patients with acute coronary syndrome (ACS).

    Authors: Eyal Leibovitz, Shmuel Gottlieb, Ilan Goldenberg, Natalie Gevrielov-Yusim, Shlomi Matetzky and Dov Gavish
    Citation: Cardiovascular Diabetology 2013 12:53
    Content type: Original investigation Published on:

  9. Diabetes mellitus (DM) patients surviving myocardial infarction (MI) exhibit a substantially higher incidence of subsequent heart failure (HF). Neuregulin (NRG)-1 and erythroblastic leukemia viral oncogene hom...

    Authors: Oghenerukevwe Odiete, Ewa A Konik, Douglas B Sawyer and Michael F Hill
    Citation: Cardiovascular Diabetology 2013 12:52
    Content type: Original investigation Published on:

  10. The RhoA/ROCK signaling pathway mediates vascular smooth muscle contraction while endogenous NO induces vasodilation through its inhibition. Since myosin light chain phosphatase (MLCP) and eNOS are targeted by...

    Authors: Figen Amber Cicek, Hilmi B Kandilci and Belma Turan
    Citation: Cardiovascular Diabetology 2013 12:51
    Content type: Original investigation Published on:

  11. The Editors of Cardiovascular Diabetology wish to thank all reviewers, both Editorial Board Members and external referees, who contributed to the journal in 2012 (Volume 11), and whose enthusiastic support in ...

    Authors: Alexander Tenenbaum and Enrique Fisman
    Citation: Cardiovascular Diabetology 2013 12:43
    Content type: Reviewer acknowledgement Published on:

  12. Given the importance of inflammation in the onset and progression of diabetic cardiomyopathy, we investigated the potential protective effects of triptolide, an anti-inflammatory agent, in streptozotocin-induc...

    Authors: He-Ling Wen, Zhong-Shu Liang, Rui Zhang and Kan Yang
    Citation: Cardiovascular Diabetology 2013 12:50
    Content type: Original investigation Published on:

  13. There has been accumulating evidence associating diabetes mellitus and cardiovascular dysfunctions. However, most of the studies are focused on the late stages of diabetes and on the function of large arteries...

    Authors: Evangelia Mourmoura, Guillaume Vial, Brigitte Laillet, Jean-Paul Rigaudière, Isabelle Hininger-Favier, Hervé Dubouchaud, Beatrice Morio and Luc Demaison
    Citation: Cardiovascular Diabetology 2013 12:49
    Content type: Original investigation Published on:

  14. Diabetes is associated with a higher risk for adverse cardiovascular outcomes. To improve the health outcomes of patients with type 2 diabetes (T2DM), the American Diabetes Association (ADA) recommended target...

    Authors: Alison R Meloni, Mary Beth DeYoung, Jenny Han, Jennie H Best and Michael Grimm
    Citation: Cardiovascular Diabetology 2013 12:48
    Content type: Original investigation Published on:

  15. Type-2 diabetes mellitus has a major impact on health related quality of life (HRQoL). We aimed to identify patient and treatment related variables having a major impact.

    Authors: Jürgen Wasem, Peter Bramlage, Anselm K Gitt, Christiane Binz, Michael Krekler, Evelin Deeg and Diethelm Tschöpe
    Citation: Cardiovascular Diabetology 2013 12:47
    Content type: Original investigation Published on:

  16. Adiponectin is able to induce NO-dependent vasodilation in Zucker lean (ZL) rats, but this effect is clearly alleviated in their diabetic littermates, the Zucker diabetic fatty (ZDF) rats. ZDF rats also exhibi...

    Authors: Peter M Schmid, Markus Resch, Christian Schach, Christoph Birner, Guenter A Riegger, Andreas Luchner and Dierk H Endemann
    Citation: Cardiovascular Diabetology 2013 12:46
    Content type: Original investigation Published on:

  17. We tested the effects of structured health care for the diabetic foot in one region in Germany aiming to reduce the number of major amputations.

    Authors: Matthias Weck, Torsten Slesaczeck, Hartmut Paetzold, Dirk Muench, Thomas Nanning, Georg von Gagern, Andrej Brechow, Ulf Dietrich, Mandy Holfert, Stefan Bornstein, Andreas Barthel, Antje Thomas, Carsta Koehler and Markolf Hanefeld
    Citation: Cardiovascular Diabetology 2013 12:45
    Content type: Original investigation Published on:

  18. Diabetic cardiomyopathy (DCM) is defined as structural and functional changes in the myocardium due to metabolic and cellular abnormalities induced by diabetes mellitus (DM). The impact of prediabetic conditio...

    Authors: Sara Nunes, Edna Soares, João Fernandes, Sofia Viana, Eugénia Carvalho, Frederico C Pereira and Flávio Reis
    Citation: Cardiovascular Diabetology 2013 12:44
    Content type: Original investigation Published on:

  19. Volatile anaesthetics exert protective effects on the heart against perioperative ischaemic injury. However, there is growing evidence that these cardioprotective properties are reduced in case of type 2 diabe...

    Authors: Charissa E van den Brom, Carolien SE Bulte, Stephan A Loer, R Arthur Bouwman and Christa Boer
    Citation: Cardiovascular Diabetology 2013 12:42
    Content type: Review Published on:

  20. Metabolic syndrome (MS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. However, data on the impact of MS and its individual components on subclinical atherosclerosis...

    Authors: Ki-Bum Won, Hyuk-Jae Chang, Hyeon-Chang Kim, Kyewon Jeon, Hancheol Lee, Sanghoon Shin, In-Jeong Cho, Sung-Ha Park, Sang-Hak Lee and Yangsoo Jang
    Citation: Cardiovascular Diabetology 2013 12:41
    Content type: Original investigation Published on:

  21. Diabetes mellitus (DM) exacerbates coronary artery disease (CAD) morbidity and mortality. Mesenchymal stem cells (MSCs) play an important therapeutic role in myocardial ischemic injury. However, little is know...

    Authors: Yu Liu, Zhi Li, Tao Liu, Xiaodong Xue, Hui Jiang, Jianhua Huang and Huishan Wang
    Citation: Cardiovascular Diabetology 2013 12:40
    Content type: Original investigation Published on:

  22. Apolipoprotein B100 (ApoB100) determination is superior to low-density lipoprotein cholesterol (LDL-C) to establish cardiovascular (CV) risk, and does not require prior fasting. ApoB100 is rarely measured alongsi...

    Authors: Michel P Hermans, Sylvie A Ahn and Michel F Rousseau
    Citation: Cardiovascular Diabetology 2013 12:39
    Content type: Original investigation Published on:

  23. We hypothesized that clinical factors other than glycemic control may influence abnormal cardiac function in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the independent factors for a...

    Authors: Ryoko Ichikawa, Masao Daimon, Tetsuro Miyazaki, Takayuki Kawata, Sakiko Miyazaki, Masaki Maruyama, Shuo-Ju Chiang, Hiromasa Suzuki, Chiharu Ito, Fumihiko Sato, Hirotaka Watada and Hiroyuki Daida
    Citation: Cardiovascular Diabetology 2013 12:38
    Content type: Original investigation Published on:

  24. Advanced glycation end products (AGEs), inflammatory-associated macrophage migration and accumulation are crucial for initiation and progression of diabetic vascular complication. Enzymatic activity of heparan...

    Authors: Qiaojing Qin, Jianying Niu, Zhaoxia Wang, Wangjie Xu, Zhongdong Qiao and Yong Gu
    Citation: Cardiovascular Diabetology 2013 12:37
    Content type: Original investigation Published on:

  25. Classical and delayed preconditioning are powerful endogenous protection mechanisms against ischemia-reperfusion damage. However, it is still uncertain whether delayed preconditioning can effectively salvage m...

    Authors: Gerry Van der Mieren, Ines Nevelsteen, Annelies Vanderper, Wouter Oosterlinck, Willem Flameng and Paul Herijgers
    Citation: Cardiovascular Diabetology 2013 12:36
    Content type: Original investigation Published on:

  26. Recently, incretin hormones, including glucagon-like peptide-1 (GLP-1) analogue and dipeptidyl peptidase-4 (DPP-4) inhibitor, have been found to regulate glucose metabolism. The aim of this study was to elucid...

    Authors: Yoshiko Sakamoto, Jun-ichi Oyama, Hideo Ikeda, Shigetaka Kuroki, Shigeki Gondo, Taketo Iwamoto, Yasufumi Uchida, Kazuhisa Kodama, Atsushi Hiwatashi, Mitsuhiro Shimomura, Isao Taguchi, Teruo Inoue and Koichi Node
    Citation: Cardiovascular Diabetology 2013 12:35
    Content type: Original investigation Published on:

  27. Diabetic microvascular changes are considered to be influenced by angiogenic factors. As a compensatory mechanism, the expression of some angiogenic factors are elevated in ischemic myocardium. The aim of this...

    Authors: Chun Gui, Shi-kang Li, Qin-ling Nong, Fang Du, Li-guang Zhu and Zhi-yu Zeng
    Citation: Cardiovascular Diabetology 2013 12:34
    Content type: Original investigation Published on:

  28. Acute phase hyperglycemia has been associated with increased mortality in patients with acute myocardial infarction (AMI). However, the predictive value of glycemic excursion for adverse outcome in elderly AMI...

    Authors: Gong Su, Shu-hua Mi, Zhao Li, Hong Tao, Hong-xia Yang and Hong Zheng
    Citation: Cardiovascular Diabetology 2013 12:33
    Content type: Original investigation Published on:

  29. The aim of this study was to examine the effects of intense physical training on vascular function in streptozotocin-diabetic rats. We focused on the endothelium-dependent relaxation (EDR) induced by acetylcho...

    Authors: Mohamed Sami Zguira, Sophie Vincent, Solène Le Douairon Lahaye, Ludivine Malarde, Zouhair Tabka and Bernard Saïag
    Citation: Cardiovascular Diabetology 2013 12:32
    Content type: Original investigation Published on:

  30. Haptoglobin (HP) is an acute phase protein that binds to freely circulating hemoglobin. HP exists as two distinct forms, HP1 and HP2. The longer HP2 form has been associated with cardiovascular (CVD) events an...

    Authors: Jeremy N Adams, Amanda J Cox, Barry I Freedman, Carl D Langefeld, J Jeffrey Carr and Donald W Bowden
    Citation: Cardiovascular Diabetology 2013 12:31
    Content type: Original investigation Published on:

  31. Peroxisome-proliferator–activated-receptor-γ (PPARγ) acts as a transcriptional regulator of multiple genes involved in glucose and lipid metabolism. In vitro studies showed that activated PPARγ suppresses AT1R...

    Authors: Vedat Tiyerili, Ulrich M Becher, Adem Aksoy, Dieter Lütjohann, Sven Wassmann, Georg Nickenig and Cornelius FH Mueller
    Citation: Cardiovascular Diabetology 2013 12:30
    Content type: Original investigation Published on:

  32. Limited studies have suggested that inflammatory biomarkers play a role in the initiation and progression of atherosclerosis in diabetic patients. This study assesses the effect of inflammatory biomarkers: fib...

    Authors: Marijan Bosevski, Golubinka Bosevska and Lily Stojanovska
    Citation: Cardiovascular Diabetology 2013 12:29
    Content type: Original investigation Published on:

  33. Defective copper regulation is implicated as a causative mechanism of organ damage in diabetes. Treatment with trientine, a divalent-copper-selective chelator, improves arterial and renal structure/function in...

    Authors: Jun Lu, Beau Pontré, Stephen Pickup, Soon Y Choong, Mingming Li, Hong Xu, Gregory D Gamble, Anthony RJ Phillips, Brett R Cowan, Alistair A Young and Garth JS Cooper
    Citation: Cardiovascular Diabetology 2013 12:28
    Content type: Original investigation Published on:

  34. Dysfunctional high-density lipoprotein (HDL) may have pro-inflammatory effects on the endothelial cells,which causes atherosclerosis in type 2 diabetes mellitus (T2DM). HDL is a major carrier of sphingosine-1-...

    Authors: Xunliang Tong, Hui Peng, Donghui Liu, Liang Ji, Chenguang Niu, Jun Ren, Bing Pan, Jianying Hu, Lemin Zheng and Yining Huang
    Citation: Cardiovascular Diabetology 2013 12:27
    Content type: Original investigation Published on:

  35. Diabetes is characterized by profound lipid abnormalities. The objective of this study was to examine changes in concentrations of lipids and apolipoprotein B among participants stratified by glycemic status (...

    Authors: Earl S Ford, Chaoyang Li and Allan Sniderman
    Citation: Cardiovascular Diabetology 2013 12:26
    Content type: Original investigation Published on:

  36. Red blood cells (RBCs) are highly deformable and possess a robust membrane that can withstand shear force. Previous research showed that in diabetic patients, there is a changed RBC ultrastructure, where these...

    Authors: Antoinette V Buys, Mia-Jean Van Rooy, Prashilla Soma, Dirk Van Papendorp, Boguslaw Lipinski and Etheresia Pretorius
    Citation: Cardiovascular Diabetology 2013 12:25
    Content type: Original investigation Published on:

  40. We developed a simple and new insulin resistance index derived from a glucose clamp and a meal tolerance test (MTT) in Japanese patients with type 2 diabetes mellitus.

    Authors: Tsuyoshi Ohkura, Hideki Shiochi, Youhei Fujioka, Keisuke Sumi, Naoya Yamamoto, Kazuhiko Matsuzawa, Shoichiro Izawa, Hiroshi Kinoshita, Hiroko Ohkura, Masahiko Kato, Shin-ichi Taniguchi and Kazuhiro Yamamoto
    Citation: Cardiovascular Diabetology 2013 12:21
    Content type: Original investigation Published on:

  41. Macrovascular diseases (MVD) in type 2 diabetes mellitus (T2DM) are often considered all together, without discriminating the areas involved. The aim of our study was to analyse MVD prevalence in a large popul...

    Authors: Giuseppe Papa, Claudia Degano, Maria P Iurato, Carmelo Licciardello, Raffaella Maiorana and Concetta Finocchiaro
    Citation: Cardiovascular Diabetology 2013 12:20
    Content type: Original investigation Published on:

  42. Diabetes increases the risk of cardiovascular complications including arrhythmias, but the underlying mechanisms remain to be established. Decreased conduction velocity (CV), which is an independent risk facto...

    Authors: Kristine Boisen Olsen, Lene Nygaard Axelsen, Thomas Hartig Braunstein, Charlotte Mehlin Sørensen, Claus B Andersen, Thorkil Ploug, Niels-Henrik Holstein-Rathlou and Morten Schak Nielsen
    Citation: Cardiovascular Diabetology 2013 12:19
    Content type: Original investigation Published on:

  43. The features of carotid atherosclerosis in ketosis-onset diabetes have not been investigated. Our aim was to evaluate the prevalence and clinical characteristics of carotid atherosclerosis in newly diagnosed C...

    Authors: Lian-Xi Li, Cui-Chun Zhao, Ying Ren, Yin-Fang Tu, Jun-Xi Lu, Xing Wu, Wei-Xing Zhang, Jia-An Zhu, Mei-Fang Li, Li-Bo Yu, Yu-Qian Bao and Wei-Ping Jia
    Citation: Cardiovascular Diabetology 2013 12:18
    Content type: Original investigation Published on:

  44. Lipoprotein lipase (LPL) and serum 25-hydroxyvitamin D [25(OH)D] play important roles in the regulation of lipid metabolism. Although dyslipidemia is associated with insulin resistance (IR) and type 2 diabetes...

    Authors: Yifan Huang, Xiaoxia Li, Maoqing Wang, Hua Ning, Lima A, Ying Li and Changhao Sun
    Citation: Cardiovascular Diabetology 2013 12:17
    Content type: Original investigation Published on:

  45. Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expres...

    Authors: Márta Sárközy, Ágnes Zvara, Nóra Gyémánt, Veronika Fekete, Gabriella F Kocsis, Judit Pipis, Gergő Szűcs, Csaba Csonka, László G Puskás, Péter Ferdinandy and Tamás Csont
    Citation: Cardiovascular Diabetology 2013 12:16
    Content type: Original investigation Published on:

  46. The contribution of glycemic variability to macrovascular complications remains unclear. We therefore investigated the association between glycemic variability and cervical and/or intracranial atherosclerosis ...

    Authors: Yifei Mo, Jian Zhou, Mei Li, Yuwei Wang, Yuqian Bao, Xiaojing Ma, Ding Li, Wei Lu, Cheng Hu, Minghua Li and Weiping Jia
    Citation: Cardiovascular Diabetology 2013 12:15
    Content type: Original investigation Published on:

  47. Prediabetes is an independent risk factor for cardiovascular diseases. Mean platelet volume (MPV) can reflect platelet activity, and high MPV is associated with thrombogenic activation and an increased risk of...

    Authors: Masanori Shimodaira, Tomohiro Niwa, Koji Nakajima, Mutsuhiro Kobayashi, Norinao Hanyu and Tomohiro Nakayama
    Citation: Cardiovascular Diabetology 2013 12:14
    Content type: Original investigation Published on:

  48. Hyperglycemia could induce oxidative stress, activate transcription factor nuclear factor kappa B (NF-κB), up-regulate expression of endothelial adhesion molecules, and lead to endothelial injury. Studies have...

    Authors: Minmin Zhu, Jiawei Chen, Hui Jiang and Changhong Miao
    Citation: Cardiovascular Diabetology 2013 12:13
    Content type: Original investigation Published on:

  49. Patients with diabetes mellitus (DM) have an increased risk for periprocedural complications and adverse cardiac events after percutaneous coronary intervention. We addressed the potential for coronary microva...

    Authors: Theodor Baars, Thomas Konorza, Philipp Kahlert, Stefan Möhlenkamp, Raimund Erbel, Gerd Heusch and Petra Kleinbongard
    Citation: Cardiovascular Diabetology 2013 12:12
    Content type: Original investigation Published on:

  50. Although an association between low-level environmental heavy metal exposure and the incidence of metabolic syndrome (MS) has been hypothesized, little research on this topic has been conducted on a population...

    Authors: Sang Youl Rhee, You-Cheol Hwang, Jeong-taek Woo, Dong Hyun Sinn, Sang Ouk Chin, Suk Chon and Young Seol Young Seol Kim
    Citation: Cardiovascular Diabetology 2013 12:9
    Content type: Original investigation Published on:
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ISSN: 1475-2840