Watson AM, Gray SP, Jiaze L, Soro-Paavonen A, Wong B, Cooper ME, Bierhaus A, Pickering R, Tikellis C, Tsorotes D, Thomas MC, Jandeleit-Dahm KA: Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGE activation in diabetic apolipoprotein E knockout mice. Diabetes. 2012, 61 (8): 2105-2113. 10.2337/db11-1546.
Article
PubMed Central
CAS
PubMed
Google Scholar
Soetikno V, Sari FR, Veeraveedu PT, Thandavarayan RA, Harima M, Sukumaran V, Lakshmanan AP, Suzuki K, Kawachi H, Watanabe K: Curcumin ameliorates macrophage infiltration by inhibiting NF-κB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy. Nutr Metab (Lond). 2011, 8 (1): 35-10.1186/1743-7075-8-35.
Article
CAS
Google Scholar
Rosenson RS, Fioretto P, Dodson PM: Does microvascular disease predict macrovascular events in type 2 diabetes?. Atherosclerosis. 2011, 218 (1): 13-18. 10.1016/j.atherosclerosis.2011.06.029.
Article
CAS
PubMed
Google Scholar
Marino F, Maresca AM, Cosentino M, Castiglioni L, Rasini E, Mongiardi C, Maio RC, Legnaro M, Schembri L, Dentali F, Grandi AM, Guasti L: Angiotensin II type 1 and type 2 receptor expression in circulating monocytes of diabetic and hypercholesterolemic patients over 3-month rosuvastatin treatment. Cardiovasc Diabetol. 2012, 11: 153-10.1186/1475-2840-11-153.
Article
PubMed Central
CAS
PubMed
Google Scholar
Coughlan MT, Yap FY, Tong DC, Andrikopoulos S, Gasser A, Thallas-Bonke V, Webster DE, Miyazaki J, Kay TW, Slattery RM, Kaye DM, Drew BG, Kingwell BA, Fourlanos S, Groop PH, Harrison LC, Knip M, Forbes JM: Advanced glycation end products are direct modulators of β-cell function. Diabetes. 2011, 60 (10): 2523-2532. 10.2337/db10-1033.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zhong Y, Li J, Chen Y, Wang JJ, Ratan R, Zhang SX: Activation of endoplasmic reticulum stress by hyperglycemia is essential for Muller cell-derived inflammatory cytokine production in diabetes. Diabetes. 2012, 61 (2): 492-504. 10.2337/db11-0315.
Article
PubMed Central
CAS
PubMed
Google Scholar
Raposeiras-Roubín S, Rodiño-Janeiro BK, Paradela-Dobarro B, Grigorian-Shamagian L, García-Acuña JM, Aguiar-Souto P, Jacquet-Hervet M, Reino-Maceiras MV, Alvarez E, González-Juanatey JR: Predictive value of advanced glycation end products for the development of post-infarction heart failure: a preliminary report. Cardiovasc Diabetol. 2012, 11: 102-10.1186/1475-2840-11-102.
Article
PubMed Central
PubMed
Google Scholar
Peterson S, Liu J: Deciphering mode of action of heparanase using structurally defined oligosaccharides. J Biol Chem. 2012, 287 (41): 34836-34843. 10.1074/jbc.M112.390161.
Article
PubMed Central
CAS
PubMed
Google Scholar
Shafat I, Agbaria A, Boaz M, Schwartz D, Baruch R, Nakash R, Ilan N, Vlodavsky I, Weinstein T: Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft function. PLoS One. 2012, 7 (9): e44076-10.1371/journal.pone.0044076.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bhattacharjee PS, Huq TS, Potter V, Young A, Davenport IR, Graves R, Mandal TK, Clement C, McFerrin HE, Muniruzzaman S, Ireland SK, Hill JM: High-glucose-induced endothelial cell injury is inhibited by a Peptide derived from human apolipoprotein e. PLoS One. 2012, 7 (12): e52152-10.1371/journal.pone.0052152.
Article
PubMed Central
CAS
PubMed
Google Scholar
Purushothaman A, Babitz SK, Sanderson RD: Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma. J Biol Chem. 2012, 287 (49): 41288-41296. 10.1074/jbc.M112.391417.
Article
PubMed Central
CAS
PubMed
Google Scholar
Cohen-Kaplan V, Jrbashyan J, Yanir Y, Naroditsky I, Ben-Izhak O, Ilan N, Doweck I, Vlodavsky I: Heparanase induces signal transducer and activator of transcription (STAT) protein phosphorylation: preclinical and clinical significance in head and neck cancer. J Biol Chem. 2012, 287 (9): 6668-66678. 10.1074/jbc.M111.271346.
Article
PubMed Central
CAS
PubMed
Google Scholar
Purushothaman A, Uyama T, Kobayashi F, Yamada S, Sugahara K, Rapraeger AC, Sanderson RD: Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis. Blood. 2010, 115 (12): 2449-2457. 10.1182/blood-2009-07-234757.
Article
PubMed Central
CAS
PubMed
Google Scholar
Xu X, Rao G, Quiros RM, Kim AW, Miao HQ, Brunn GJ, Platt JL, Gattuso P, Prinz RA: In vivo and in vitro degradation of heparan sulfate (HS) proteoglycans by HPR1 in pancreatic adenocarcinomas. Loss of cell surface HS suppresses fibroblast growth factor 2-mediated cell signaling and proliferation. J Biol Chem. 2007, 282 (4): 2363-2373.
Article
CAS
PubMed
Google Scholar
Osterholm C, Folkersen L, Lengquist M, Pontén F, Renné T, Li J, Hedin U: Increased expression of heparanase in symptomatic carotid atherosclerosis. Atherosclerosis. 2013, 226 (1): 67-73. 10.1016/j.atherosclerosis.2012.09.030.
Article
CAS
PubMed
Google Scholar
Gil N, Goldberg R, Neuman T, Garsen M, Zcharia E, Rubinstein AM, van Kuppevelt T, Meirovitz A, Pisano C, Li JP, van der Vlag J, Vlodavsky I, Elkin M: Heparanase is essential for the development of diabetic nephropathy in mice. Diabetes. 2012, 61 (1): 208-216. 10.2337/db11-1024.
Article
PubMed Central
CAS
PubMed
Google Scholar
Baker AB, Chatzizisis YS, Beigel R, Jonas M, Stone BV, Coskun AU, Maynard C, Rogers C, Koskinas KC, Feldman CL, Stone PH, Edelman ER: Regulation of heparanase expression in coronary artery disease in diabetic, hyperlipidemic swine. Atherosclerosis. 2010, 213 (2): 436-442. 10.1016/j.atherosclerosis.2010.09.003.
Article
PubMed Central
CAS
PubMed
Google Scholar
Masola V, Gambaro G, Tibaldi E, Onisto M, Abaterusso C, Lupo A: Regulation of heparanase by albumin and advanced glycation end products in proximal tubular cells. Biochim Biophys Acta. 2011, 1813 (8): 1475-1482. 10.1016/j.bbamcr.2011.05.004.
Article
CAS
PubMed
Google Scholar
An XF, Zhou L, Jiang PJ, Yan M, Huang YJ, Zhang SN, Niu YF, Ten SC, Yu JY: Advanced glycation end-products induce heparanase expression in endothelial cells by the receptor for advanced glycation end products and through activation of the FOXO4 transcription factor. Mol Cell Biochem. 2011, 354 (1–2): 47-55.
Article
CAS
PubMed
Google Scholar
Rao G, Ding HG, Huang W, Le D, Maxhimer JB, Oosterhof A, van Kuppevelt T, Lum H, Lewis EJ, Reddy V, Prinz RA, Xu X: Reactive oxygen species mediate high glucose-induced heparanase-1 production and heparan sulphate proteoglycan degradation in human and rat endothelial cells: a potential role in the pathogenesis of atherosclerosis. Diabetologia. 2011, 54 (6): 1527-1538. 10.1007/s00125-011-2110-z.
Article
CAS
PubMed
Google Scholar
Li H, Peng W, Jian W, Li Y, Li Q, Li W, Xu Y: ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion. Cardiovasc Diabetol. 2012, 11: 65-10.1186/1475-2840-11-65.
Article
PubMed Central
CAS
PubMed
Google Scholar
Teixeira-Lemos E, Nunes S, Teixeira F, Reis F: Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties. Cardiovasc Diabetol. 2011, 10: 12-10.1186/1475-2840-10-12.
Article
PubMed Central
PubMed
Google Scholar
Wen Y, Gu J, Li SL, Reddy MA, Natarajan R, Nadler JL: Elevated glucose and diabetes promote interleukin-12 cytokine gene expression in mouse macrophages. Endocrinology. 2006, 147 (5): 2518-2525. 10.1210/en.2005-0519.
Article
CAS
PubMed
Google Scholar
Li Y, Liu S, Zhang Z, Xu Q, Xie F, Wang J, Ping S, Li C, Wang Z, Zhang M, Huang J, Chen D, Hu L, Li C: RAGE mediates accelerated diabetic vein graft atherosclerosis induced by combined mechanical stress and AGEs via synergistic ERK activation. PLoS One. 2012, 7 (4): e35016-10.1371/journal.pone.0035016.
Article
PubMed Central
CAS
PubMed
Google Scholar
Soulis V, Thallas S, Youssef RE, Gilbert BG, McWilliam RP, Murray-McIntosh RP, Cooper ME: Advanced glycation end products and their receptors co-localise in rat organs susceptible to diabetic microvascular injury. Diabetologia. 1997, 40 (6): 619-628. 10.1007/s001250050725.
Article
CAS
PubMed
Google Scholar
Xu Y, Feng L, Wang S, Zhu Q, Lin J, Lou C, Xiang P, He B, Zheng Z, Tang D, Zuo G: Phytoestrogen calycosin-7-O-β-D-glucopyranoside ameliorates advanced glycation end products-induced HUVEC damage. J Cell Biochem. 2011, 112 (10): 2953-2965. 10.1002/jcb.23212.
Article
CAS
PubMed
Google Scholar
Cohen E, Doweck I, Naroditsky I, Ben-Izhak O, Kremer R, Best LA, Vlodavsky I, Ilan N: Heparanase is overexpressed in lung cancer and correlates inversely with patient survival. Cancer. 2008, 113 (5): 1004-1011. 10.1002/cncr.23680.
Article
PubMed Central
PubMed
Google Scholar
Li JP, Vlodavsky I: Heparin, heparan sulfate and heparanase in inflammatory reactions. Thromb Haemost. 2009, 102 (5): 823-828.
CAS
PubMed
Google Scholar
Blich M, Golan A, Arvatz G, Sebbag A, Shafat I, Sabo E, Cohen-Kaplan V, Petcherski S, Avniel-Polak S, Eitan A, Hammerman H, Aronson D, Axelman E, Ilan N, Nussbaum G, Vlodavsky I: Macrophage Activation by Heparanase Is Mediated by TLR-2 and TLR-4 and Associates With Plaque Progression. Arterioscler Thromb Vasc Biol. 2013, 33 (2): e56-e65. 10.1161/ATVBAHA.112.254961.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fux L, Feibish N, Cohen-Kaplan V, Gingis-Velitski S, Feld S, Geffen C, Vlodavsky I, Ilan N: Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling. Cancer Res. 2009, 69 (5): 1758-1767. 10.1158/0008-5472.CAN-08-1837.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ben-Zaken O, Gingis-Velitski S, Vlodavsky I, Ilan N:Heparanase induces Akt phosphorylation via a lipid raft receptor. Biochem Biophys Res Commun. 2007, 361 (4): 829-834. 10.1016/j.bbrc.2007.06.188.
Article
PubMed Central
CAS
PubMed
Google Scholar
Rubinfeld H, Cohen-Kaplan V, Nass D, Ilan N, Meisel S, Cohen ZR, Hadani M, Vlodavsky I, Shimon I:Heparanase is highly expressed and regulates proliferation in GH-secreting pituitary tumor cells. Endocrinology. 2011, 152 (12): 4562-4570. 10.1210/en.2011-0273.
Article
CAS
PubMed
Google Scholar
Masola V, Gambaro G, Tibaldi E, Brunati AM, Gastaldello A, D’Angelo A, Onisto M, Lupo A:Heparanase and Syndecan-1 Interplay Orchestrates Fibroblast Growth Factor-2-induced Epithelial-Mesenchymal Transition in Renal Tubular Cells. J Biol Chem. 2012, 287 (2): 1478-1488. 10.1074/jbc.M111.279836.
Article
PubMed Central
CAS
PubMed
Google Scholar
Boudot C, Saidak Z, Boulanouar AK, Petit L, Gouilleux F, Massy Z, Brazier M, Mentaverri R, Kamel S:Implication of the calcium sensing receptor and the Phosphoinositide 3-kinase/Akt pathway in the extracellular calcium-mediated migration of RAW 264.7 osteoclast precursor cells. Bone. 2010, 46 (5): 1416-1423. 10.1016/j.bone.2010.01.383.
Article
CAS
PubMed
Google Scholar
Granado MH, Gangoiti P, Ouro A, Arana L, González M, Trueba M, Gómez-Muñoz A:Ceramide 1-phosphate (C1P) promotes cell migration Involvement of a specific C1P receptor. Cell Signal. 2009, 21 (3): 405-412. 10.1016/j.cellsig.2008.11.003.
Article
CAS
PubMed
Google Scholar
Ghosh P, Garcia-Marcos M, Bornheimer SJ, Farquhar MG:Activation of Galphai3 triggers cell migration via regulation of GIV. J Cell Biol. 2008, 182 (2): 381-393. 10.1083/jcb.200712066.
Article
PubMed Central
CAS
PubMed
Google Scholar
Xu Y, Feng L, Wang S, Zhu Q, Zheng Z, Xiang P, He B, Tang D:Calycosin protects HUVECs from advanced glycation end products-induced macrophage infiltration. J Ethnopharmacol. 2011, 137 (1): 359-370. 10.1016/j.jep.2011.05.041.
Article
CAS
PubMed
Google Scholar
Monden M, Koyama H, Otsuka Y, Morioka T, Mori K, Shoji T, Mima Y, Motoyama K, Fukumoto S, Shioi A, Emoto M, Yamamoto Y, Yamamoto H, Nishizawa Y, Kurajoh M, Yamamoto T, Inaba M:Receptor for advanced glycation End products regulates adipocyte hypertrophy and insulin sensitivity in mice: involvement of toll-like receptor 2. Diabetes. 2013, 62 (2): 478-489. 10.2337/db11-1116.
Article
PubMed Central
CAS
PubMed
Google Scholar
Reiniger N, Lau K, McCalla D, Eby B, Cheng B, Lu Y, Qu W, Quadri N, Ananthakrishnan R, Furmansky M, Rosario R, Song F, Rai V, Weinberg A, Friedman R, Ramasamy R, D’Agati V, Schmidt AM:Deletion of the receptor for advanced glycation end products reduces glomerulosclerosis and preserves renal function in the diabetic OVE26 mouse. Diabetes. 2010, 59 (8): 2043-2054. 10.2337/db09-1766.
Article
PubMed Central
CAS
PubMed
Google Scholar
Milutinovic PS, Alcorn JF, Englert JM, Crum LT, Oury TD:The receptor for advanced glycation end products is a central mediator of asthma pathogenesis. Am J Pathol. 2012, 181 (4): 1215-1225. 10.1016/j.ajpath.2012.06.031.
Article
PubMed Central
CAS
PubMed
Google Scholar
Tang CH, Keng YT, Liu JF:HMGB-1 induces cell motility and α5β1 integrin expression in human chondrosarcoma cells. Cancer Lett. 2012, 322 (1): 98-106. 10.1016/j.canlet.2012.02.014.
Article
CAS
PubMed
Google Scholar
Rai V, Maldonado AY, Burz DS, Reverdatto S, Schmidt AM, Shekhtman A:Signal transduction in receptor for advanced glycation end products (RAGE): solution structure of C-terminal rage (ctRAGE) and its binding to mDia1. J Biol Chem. 2012, 287 (7): 5133-5144. 10.1074/jbc.M111.277731.
Article
PubMed Central
PubMed
Google Scholar