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  1. The panoply of treatment algorithms, periodically released to improve guidance, is one mean to face therapeutic uncertainty in pharmacological management of hyperglycemia in type 2 diabetes, especially after m...

    Authors: Katherine Esposito, Sandro Gentile, Riccardo Candido, Alberto De Micheli, Marco Gallo, Gerardo Medea and Antonio Ceriello
    Citation: Cardiovascular Diabetology 2013 12:81
  2. The term cardiometabolic disease encompasses a range of lifestyle-related conditions, including Metabolic syndrome (MetS) and type 2 diabetes (T2D), that are characterized by different combinations of cardiova...

    Authors: Henry Ginsberg
    Citation: Cardiovascular Diabetology 2013 12(Suppl 1):S1

    This article is part of a Supplement: Volume 12 Supplement 1

  3. Both hyperglycaemia and dendritic cells (DCs) play causative roles in atherosclerosis. However, whether they interact in atherosclerosis remains uncertain. Therefore, we examined whether high glucose could reg...

    Authors: Hao Lu, Kang Yao, Dong Huang, Aijun Sun, Yunzeng Zou, Juying Qian and Junbo Ge
    Citation: Cardiovascular Diabetology 2013 12:80
  4. The diagnosis of diabetes mellitus (DM) is based on either fasting plasma glucose levels or an oral glucose tolerance test (OGTT). Recently, an HbA1c value of ≥ 48 mmol/mol (6.5%) has been included as an addition...

    Authors: Iren D Hjellestad, Marianne C Astor, Roy M Nilsen, Eirik Søfteland and Torbjørn Jonung
    Citation: Cardiovascular Diabetology 2013 12:79
  5. Little is known about the impact of sex-specific differences in the management of type 1 diabetes (T1DM).

    Authors: Alexandra Kautzky-Willer, Kathrin Stich, Juliane Hintersteiner, Alexander Kautzky, Majid Reza Kamyar, Johannes Saukel, Julienne Johnson and Rosa Lemmens-Gruber
    Citation: Cardiovascular Diabetology 2013 12:78
  6. Fatty liver is associated with insulin resistance, dyslipidemia, and obesity and is therefore considered a phenotype of metabolic syndrome. However, less is known regarding the metabolic abnormalities associat...

    Authors: Wan-Chen Wu and Chih-Yuan Wang
    Citation: Cardiovascular Diabetology 2013 12:77
  7. The predictive potentials of neck circumference (NC) for cardio-metabolic risks remain uncertain. The aim of this study was to investigate whether NC independently contributes to the prediction of cardio-metab...

    Authors: Jing-ya Zhou, Hui Ge, Ming-fan Zhu, Li-jun Wang, Li Chen, Yao-zong Tan, Yu-ming Chen and Hui-lian Zhu
    Citation: Cardiovascular Diabetology 2013 12:76
  8. Cardiac dysfunction is well-described in endotoxemia and diagnosed in up to 60% of patients with endotoxic shock. ATP-sensitive potassium (KATP) channels are critical to cardiac function. This study investigates ...

    Authors: Zhong-Wei Yang, Ji-Kuai Chen, Min Ni, Ting Zhao, Ya-Ping Deng, Xia Tao, Guo-Jun Jiang and Fu-Ming Shen
    Citation: Cardiovascular Diabetology 2013 12:75
  9. Post-challenge hyperglycemia (PH) is well-established as one of risk factors for coronary artery disease. However, it remains unclear whether PH affects clinical outcomes in patients with stable angina undergo...

    Authors: Shoichi Kuramitsu, Hiroyoshi Yokoi, Takenori Domei, Akihiro Nomura, Hirotoshi Watanabe, Kyohei Yamaji, Yoshimitsu Soga, Takeshi Arita, Katsuhiro Kondo, Shinichi Shirai, Kenji Ando, Koyu Sakai, Masashi Iwabuchi, Hedeyuki Nosaka and Masakiyo Nobuyoshi
    Citation: Cardiovascular Diabetology 2013 12:74
  10. Treatment with the alpha-glucosidase inhibitor (AGI) acarbose is associated with a significant reduction the risk of cardiovascular events. However, the underlying mechanisms of this effect are unclear. AGIs w...

    Authors: Miao-yan Zheng, Ju-hong Yang, Chun-yan Shan, Hong-tao Zhou, Yan-guang Xu, Ying Wang, Hui-zhu Ren, Bao-cheng Chang and Li-ming Chen
    Citation: Cardiovascular Diabetology 2013 12:73
  11. Circulating adipocyte fatty acid-binding protein (FABP4) levels are considered to be a link between obesity, insulin resistance, diabetes, and cardiovascular (CV) diseases. In vitro, FABP4 has exhibited cardiodep...

    Authors: Anna Cabré, Pilar Valdovinos, Iolanda Lázaro, Gil Bonet, Alfredo Bardají and Lluís Masana
    Citation: Cardiovascular Diabetology 2013 12:72
  12. Angiotensin receptor blockers (ARBs) are reported to provide direct protection to many organs by controlling inflammation and decreasing oxidant stress. Pioglitazone, an anti-diabetic agent that improves insul...

    Authors: Hirofumi Suzuki, Masaya Sakamoto, Takeshi Hayashi, Hiroyuki Iuchi, Kennosuke Ohashi, Tsuyoshi Isaka, Noriko Sakamoto, Yosuke Kayama, Katsuyoshi Tojo, Michihiro Yoshimura and Kazunori Utsunomiya
    Citation: Cardiovascular Diabetology 2013 12:71
  13. Empagliflozin is a potent, selective sodium glucose cotransporter 2 (SGLT2) inhibitor in development as an oral antidiabetic treatment. This QT interval study assessed potential effects of empagliflozin on ven...

    Authors: Arne Ring, Tobias Brand, Sreeraj Macha, Kerstin Breithaupt-Groegler, Gudrun Simons, Beate Walter, Hans J Woerle and Uli C Broedl
    Citation: Cardiovascular Diabetology 2013 12:70
  14. Diabetic cardiovascular complications are characterised by oxidative stress-induced endothelial dysfunction. Uncoupling protein 2 (UCP2) is a regulator of mitochondrial reactive oxygen species (ROS) generation...

    Authors: Jing Sun, Yunfei Pu, Peijian Wang, Sijiao Chen, Yu Zhao, Chan Liu, Qianhui Shang, Zhiming Zhu and Daoyan Liu
    Citation: Cardiovascular Diabetology 2013 12:69
  15. Risk stratification in individuals with type 2 diabetes (T2D) remains an important priority in the management of associated morbidity and mortality, including from cardiovascular disease (CVD). The current inv...

    Authors: Amanda J Cox, Fang-Chi Hsu, J Jeffrey Carr, Barry I Freedman and Donald W Bowden
    Citation: Cardiovascular Diabetology 2013 12:68
  16. Adiponectin, an adipokine facilitating insulin action, has antiatherogenic effects. This study investigated whether common single nucleotide polymorphisms (SNPs) in the adiponectin gene influenced plasma adipo...

    Authors: Guoxin Tong, Ningfu Wang, Jianhang Leng, Xiaoshan Tong, Yun Shen, Jianmin Yang, Xianhua Ye, Liang Zhou and Yujie Zhou
    Citation: Cardiovascular Diabetology 2013 12:67
  17. Insulin resistance (IR) is currently considered a crucial cardiovascular (CV) risk factor, which seems to play a dominant role in the evolution toward cardiac and vascular impairment. Early IR-induced cardiac ...

    Authors: Christian Cadeddu, Silvio Nocco, Davide Piano, Martino Deidda, Efisio Cossu, Marco Giorgio Baroni and Giuseppe Mercuro
    Citation: Cardiovascular Diabetology 2013 12:66
  18. Although hypercaloric interventions are associated with nutritional, endocrine, metabolic, and cardiovascular disorders in obesity experiments, a rational distinction between the effects of excess adiposity an...

    Authors: Silvio A Oliveira Junior, Carlos R Padovani, Sergio A Rodrigues, Nilza R Silva, Paula F Martinez, Dijon HS Campos, Marina P Okoshi, Katashi Okoshi, Maeli Dal-Pai and Antonio C Cicogna
    Citation: Cardiovascular Diabetology 2013 12:65
  19. Endothelial dysfunction, largely dependent on impaired nitric oxide bioavailability, has been reportedly associated with incident type 2 diabetes. Our aim was to test the hypothesis that asymmetric dimethylarg...

    Authors: Andrzej Surdacki, Olga Kruszelnicka, Tomasz Rakowski, Aleksandra Jaźwińska-Kozuba and Jacek S Dubiel
    Citation: Cardiovascular Diabetology 2013 12:64
  20. The most important function of red blood cells (RBCs) is the carrying of oxygen, but they are also involved in inflammatory processes and during coagulation. RBCs are extremely deformable and elastic, as they ...

    Authors: Etheresia Pretorius
    Citation: Cardiovascular Diabetology 2013 12:63
  21. Metformin is, if not contraindicated and if tolerated, usually preferred over other antidiabetic drugs for the first line treatment of type-2 diabetes. The particular decision on which antidiabetic agent to us...

    Authors: Diethelm Tschöpe, Markolf Hanefeld, Juris J Meier, Anselm K Gitt, Martin Halle, Peter Bramlage and Petra-Maria Schumm-Draeger
    Citation: Cardiovascular Diabetology 2013 12:62
  22. The aim of this study is to evaluate the effect of gender and menopause in cardiometabolic risk in a type 2 diabetes mellitus (T2DM) population, based on classical and non-traditional markers.

    Authors: Filipa Mascarenhas-Melo, Daniela Marado, Filipe Palavra, José Sereno, Álvaro Coelho, Rui Pinto, Edite Teixeira-Lemos, Frederico Teixeira and Flávio Reis
    Citation: Cardiovascular Diabetology 2013 12:61
  23. In patients with type 2 diabetes mellitus (T2DM), hypertension and microalbuminuria are predictive markers for increased renal and cardiovascular risk. This post hoc analysis of data from a global development pro...

    Authors: Maximilian von Eynatten, Yan Gong, Angela Emser and Hans-Juergen Woerle
    Citation: Cardiovascular Diabetology 2013 12:60
  24. Numerous rheological and microvascular alterations characterize the vascular pathology in patients with type 2 diabetes mellitus (T2DM). This study investigated effects of vildagliptin in comparison to glimepi...

    Authors: Christine Berndt-Zipfel, Georg Michelson, Markus Dworak, Michael Mitry, Andrea Löffler, Andreas Pfützner and Thomas Forst
    Citation: Cardiovascular Diabetology 2013 12:59
  25. Insulin resistance is strongly associated with the development of type 2 diabetes and cardiovascular disease. However, the underlying mechanisms linking insulin resistance and the development of atherosclerosi...

    Authors: Jianxin Lu, Jingzhang Ji, Howard Meng, David Wang, Bo Jiang, Lixin Liu, Edward Randell, Khosrow Adeli and Qing H Meng
    Citation: Cardiovascular Diabetology 2013 12:58
  26. Pigment epithelium-derived factor (PEDF) has been proved to be closely correlated with metabolic syndrome (MetS) and its components that are all risk factors of cardiovascular disease and may play a protective...

    Authors: Feifei Wang, Xiaojing Ma, Mi Zhou, Xiaoping Pan, Jie Ni, Meifang Gao, Zhigang Lu, Jingyu Hang, Yuqian Bao and Weiping Jia
    Citation: Cardiovascular Diabetology 2013 12:56
  27. Anthropometric measurements are useful in clinical practice since they are non-invasive and cheap. Previous studies suggest that sagittal abdominal diameter (SAD) may be a better measure of visceral fat depots...

    Authors: Elsa M Dahlén, Niclas Bjarnegård, Toste Länne, Fredrik H Nystrom and Carl J Östgren
    Citation: Cardiovascular Diabetology 2013 12:55
  28. Cardiovascular diseases remain a leading cause of the mortality world-wide, which is related to several risks, including the life style change and the increased diabetes prevalence. The present study was to ex...

    Authors: Xiao Miao, Yonggang Wang, Jian Sun, Weixia Sun, Yi Tan, Lu Cai, Yang Zheng, Guanfang Su, Quan Liu and Yuehui Wang
    Citation: Cardiovascular Diabetology 2013 12:54
  29. Chronic treatment with currently available oral hypoglyemic medications may result in a differential effect on the clinical presentation of diabetic patients with acute coronary syndrome (ACS).

    Authors: Eyal Leibovitz, Shmuel Gottlieb, Ilan Goldenberg, Natalie Gevrielov-Yusim, Shlomi Matetzky and Dov Gavish
    Citation: Cardiovascular Diabetology 2013 12:53
  30. Diabetes mellitus (DM) patients surviving myocardial infarction (MI) exhibit a substantially higher incidence of subsequent heart failure (HF). Neuregulin (NRG)-1 and erythroblastic leukemia viral oncogene hom...

    Authors: Oghenerukevwe Odiete, Ewa A Konik, Douglas B Sawyer and Michael F Hill
    Citation: Cardiovascular Diabetology 2013 12:52
  31. The RhoA/ROCK signaling pathway mediates vascular smooth muscle contraction while endogenous NO induces vasodilation through its inhibition. Since myosin light chain phosphatase (MLCP) and eNOS are targeted by...

    Authors: Figen Amber Cicek, Hilmi B Kandilci and Belma Turan
    Citation: Cardiovascular Diabetology 2013 12:51
  32. The Editors of Cardiovascular Diabetology wish to thank all reviewers, both Editorial Board Members and external referees, who contributed to the journal in 2012 (Volume 11), and whose enthusiastic support in ...

    Authors: Alexander Tenenbaum and Enrique Fisman
    Citation: Cardiovascular Diabetology 2013 12:43
  33. Given the importance of inflammation in the onset and progression of diabetic cardiomyopathy, we investigated the potential protective effects of triptolide, an anti-inflammatory agent, in streptozotocin-induc...

    Authors: He-Ling Wen, Zhong-Shu Liang, Rui Zhang and Kan Yang
    Citation: Cardiovascular Diabetology 2013 12:50
  34. There has been accumulating evidence associating diabetes mellitus and cardiovascular dysfunctions. However, most of the studies are focused on the late stages of diabetes and on the function of large arteries...

    Authors: Evangelia Mourmoura, Guillaume Vial, Brigitte Laillet, Jean-Paul Rigaudière, Isabelle Hininger-Favier, Hervé Dubouchaud, Beatrice Morio and Luc Demaison
    Citation: Cardiovascular Diabetology 2013 12:49
  35. Diabetes is associated with a higher risk for adverse cardiovascular outcomes. To improve the health outcomes of patients with type 2 diabetes (T2DM), the American Diabetes Association (ADA) recommended target...

    Authors: Alison R Meloni, Mary Beth DeYoung, Jenny Han, Jennie H Best and Michael Grimm
    Citation: Cardiovascular Diabetology 2013 12:48
  36. Type-2 diabetes mellitus has a major impact on health related quality of life (HRQoL). We aimed to identify patient and treatment related variables having a major impact.

    Authors: Jürgen Wasem, Peter Bramlage, Anselm K Gitt, Christiane Binz, Michael Krekler, Evelin Deeg and Diethelm Tschöpe
    Citation: Cardiovascular Diabetology 2013 12:47
  37. Adiponectin is able to induce NO-dependent vasodilation in Zucker lean (ZL) rats, but this effect is clearly alleviated in their diabetic littermates, the Zucker diabetic fatty (ZDF) rats. ZDF rats also exhibi...

    Authors: Peter M Schmid, Markus Resch, Christian Schach, Christoph Birner, Guenter A Riegger, Andreas Luchner and Dierk H Endemann
    Citation: Cardiovascular Diabetology 2013 12:46
  38. We tested the effects of structured health care for the diabetic foot in one region in Germany aiming to reduce the number of major amputations.

    Authors: Matthias Weck, Torsten Slesaczeck, Hartmut Paetzold, Dirk Muench, Thomas Nanning, Georg von Gagern, Andrej Brechow, Ulf Dietrich, Mandy Holfert, Stefan Bornstein, Andreas Barthel, Antje Thomas, Carsta Koehler and Markolf Hanefeld
    Citation: Cardiovascular Diabetology 2013 12:45
  39. Diabetic cardiomyopathy (DCM) is defined as structural and functional changes in the myocardium due to metabolic and cellular abnormalities induced by diabetes mellitus (DM). The impact of prediabetic conditio...

    Authors: Sara Nunes, Edna Soares, João Fernandes, Sofia Viana, Eugénia Carvalho, Frederico C Pereira and Flávio Reis
    Citation: Cardiovascular Diabetology 2013 12:44
  40. Volatile anaesthetics exert protective effects on the heart against perioperative ischaemic injury. However, there is growing evidence that these cardioprotective properties are reduced in case of type 2 diabe...

    Authors: Charissa E van den Brom, Carolien SE Bulte, Stephan A Loer, R Arthur Bouwman and Christa Boer
    Citation: Cardiovascular Diabetology 2013 12:42
  41. Metabolic syndrome (MS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. However, data on the impact of MS and its individual components on subclinical atherosclerosis...

    Authors: Ki-Bum Won, Hyuk-Jae Chang, Hyeon-Chang Kim, Kyewon Jeon, Hancheol Lee, Sanghoon Shin, In-Jeong Cho, Sung-Ha Park, Sang-Hak Lee and Yangsoo Jang
    Citation: Cardiovascular Diabetology 2013 12:41
  42. Diabetes mellitus (DM) exacerbates coronary artery disease (CAD) morbidity and mortality. Mesenchymal stem cells (MSCs) play an important therapeutic role in myocardial ischemic injury. However, little is know...

    Authors: Yu Liu, Zhi Li, Tao Liu, Xiaodong Xue, Hui Jiang, Jianhua Huang and Huishan Wang
    Citation: Cardiovascular Diabetology 2013 12:40
  43. Apolipoprotein B100 (ApoB100) determination is superior to low-density lipoprotein cholesterol (LDL-C) to establish cardiovascular (CV) risk, and does not require prior fasting. ApoB100 is rarely measured alongsi...

    Authors: Michel P Hermans, Sylvie A Ahn and Michel F Rousseau
    Citation: Cardiovascular Diabetology 2013 12:39
  44. We hypothesized that clinical factors other than glycemic control may influence abnormal cardiac function in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the independent factors for a...

    Authors: Ryoko Ichikawa, Masao Daimon, Tetsuro Miyazaki, Takayuki Kawata, Sakiko Miyazaki, Masaki Maruyama, Shuo-Ju Chiang, Hiromasa Suzuki, Chiharu Ito, Fumihiko Sato, Hirotaka Watada and Hiroyuki Daida
    Citation: Cardiovascular Diabetology 2013 12:38
  45. Advanced glycation end products (AGEs), inflammatory-associated macrophage migration and accumulation are crucial for initiation and progression of diabetic vascular complication. Enzymatic activity of heparan...

    Authors: Qiaojing Qin, Jianying Niu, Zhaoxia Wang, Wangjie Xu, Zhongdong Qiao and Yong Gu
    Citation: Cardiovascular Diabetology 2013 12:37
  46. Classical and delayed preconditioning are powerful endogenous protection mechanisms against ischemia-reperfusion damage. However, it is still uncertain whether delayed preconditioning can effectively salvage m...

    Authors: Gerry Van der Mieren, Ines Nevelsteen, Annelies Vanderper, Wouter Oosterlinck, Willem Flameng and Paul Herijgers
    Citation: Cardiovascular Diabetology 2013 12:36
  47. Recently, incretin hormones, including glucagon-like peptide-1 (GLP-1) analogue and dipeptidyl peptidase-4 (DPP-4) inhibitor, have been found to regulate glucose metabolism. The aim of this study was to elucid...

    Authors: Yoshiko Sakamoto, Jun-ichi Oyama, Hideo Ikeda, Shigetaka Kuroki, Shigeki Gondo, Taketo Iwamoto, Yasufumi Uchida, Kazuhisa Kodama, Atsushi Hiwatashi, Mitsuhiro Shimomura, Isao Taguchi, Teruo Inoue and Koichi Node
    Citation: Cardiovascular Diabetology 2013 12:35
  48. Diabetic microvascular changes are considered to be influenced by angiogenic factors. As a compensatory mechanism, the expression of some angiogenic factors are elevated in ischemic myocardium. The aim of this...

    Authors: Chun Gui, Shi-kang Li, Qin-ling Nong, Fang Du, Li-guang Zhu and Zhi-yu Zeng
    Citation: Cardiovascular Diabetology 2013 12:34

Cardiovascular Diabetology is affiliated with Sackler Faculty of Medicine, Tel-Aviv University

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