Articles

Glucose variability and the risks of stroke, myocardial infarction, and all-cause mortality in individuals with diabetes: retrospective cohort study

Previous research regarding long-term glucose variability over several years which is an emerging indicator of glycemic control in diabetes showed several limitations. We investigated whether variability in lo...

Authors: Da Young Lee, Kyungdo Han, Sanghyun Park, Ji Hee Yu, Ji A. Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park and Nan Hee Kim

Arterial stiffness is an independent predictor for risk of mortality in patients with type 2 diabetes mellitus: the REBOUND study

This study aimed to evaluate the benefit of brachial-ankle pulse wave velocity (baPWV) as a noninvasive marker of arterial stiffness for the prediction of all-cause and cause-specific mortality in patients wit...

Authors: Jeong Mi Kim, Sang Soo Kim, In Joo Kim, Jong Ho Kim, Bo Hyun Kim, Mi Kyung Kim, Soon Hee Lee, Chang Won Lee, Min Chul Kim, Jun Hyeob Ahn and Jinmi Kim

Type 2 diabetes is an independent predictor of lowered peak aerobic capacity in heart failure patients with non-reduced or reduced left ventricular ejection fraction

Although type 2 diabetes mellitus (T2DM) is one of the most frequent comorbidities in patients with chronic heart failure (CHF), the effects of T2DM on the exercise capacity of CHF patients are fully unknown. ...

Authors: Takahiro Abe, Takashi Yokota, Arata Fukushima, Naoya Kakutani, Takashi Katayama, Ryosuke Shirakawa, Satoshi Maekawa, Hideo Nambu, Yoshikuni Obata, Katsuma Yamanashi, Ippei Nakano, Shingo Takada, Isao Yokota, Koichi Okita, Shintaro Kinugawa and Toshihisa Anzai

Does acute treatment of dapagliflozin reduce cardiac infarct size through direct cardiac effects or reductions in blood glucose levels?

Authors: Coert J. Zuurbier

Circulating Receptor Activator of Nuclear Factor kB Ligand and triglycerides are associated with progression of lower limb arterial calcification in type 2 diabetes: a prospective, observational cohort study

Lower limb arterial calcification is a frequent, underestimated but serious complication of diabetes. The DIACART study is a prospective cohort study designed to evaluate the determinants of the progression of...

Authors: Olivier Bourron, Franck Phan, Mamadou Hassimiou Diallo, David Hajage, Carole-Elodie Aubert, Aurélie Carlier, Joe-Elie Salem, Christian Funck-Brentano, Salim Kemel, Philippe Cluzel, Alban Redheuil, Jean-Michel Davaine, Ziad Massy, Romuald Mentaverri, Dominique Bonnefont-Rousselot, Philippe Gillery…

Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study

Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stif...

Authors: Minghui Li, Aihua Zhan, Xiao Huang, Lihua Hu, Wei Zhou, Tao Wang, Lingjuan Zhu, Huihui Bao and Xiaoshu Cheng

Long-term trajectories of BMI predict carotid stiffness and plaque volume in type 2 diabetes older adults: a cohort study

High body mass index (BMI) is a risk factor for type 2 diabetes and cardiovascular disease. However, its relationships with indices of carotid stiffness and plaque volume are unclear. We investigated associati...

Authors: Chen Botvin Moshe, Salo Haratz, Ramit Ravona-Springer, Anthony Heymann, Lin Hung-Mo, Michal Schnaider Beeri and David Tanne

Triglyceride glucose index for the detection of asymptomatic coronary artery stenosis in patients with type 2 diabetes

Triglyceride Glucose (TyG) index has been associated with an increased risk in cardiovascular events. Silent coronary disease is common in patients with type 2 diabetes. In Vietnam, a low-middle income country...

Authors: Pham Viet Thai, Hoang Anh Tien, Huynh Van Minh and Paul Valensi

MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy

The endothelium plays a pivotal role in maintaining vascular health. Obesity is a global epidemic that has seen dramatic increases in both adult and pediatric populations. Obesity perturbs the integrity of nor...

Authors: Karima Ait-Aissa, Quynh My Nguyen, Mohanad Gabani, Adam Kassan, Santosh Kumar, Soo-Kyoung Choi, Alexis A. Gonzalez, Tahsin Khataei, Amal M. Sahyoun, Cheng Chen and Modar Kassan

Macrophage accumulation within coronary arterial wall in diabetic patients with acute coronary syndrome: a study with in-vivo intravascular imaging modalities

Macrophage accumulation in arteriosclerotic plaque of coronary arteries is involved in plaque destabilization. Atherosclerosis has been known to be progressive in patients with type 2 diabetes mellitus (DM). T...

Authors: Takaaki Kogo, Takafumi Hiro, Daisuke Kitano, Tadateru Takayama, Daisuke Fukamachi, Tomoyuki Morikawa, Mitsumasa Sudo and Yasuo Okumura

Type 2 diabetes and reduced exercise tolerance: a review of the literature through an integrated physiology approach

The association between type 2 diabetes mellitus (T2DM) and heart failure (HF) is well established. Early in the course of the diabetic disease, some degree of impaired exercise capacity (a powerful marker of ...

Authors: Lorenzo Nesti, Nicola Riccardo Pugliese, Paolo Sciuto and Andrea Natali

Visit-to-visit HbA_1c variability is associated with in-stent restenosis in patients with type 2 diabetes after percutaneous coronary intervention

Patients with type 2 diabetes are under substantially higher risk of in-stent restenosis (ISR) after coronary stent implantation. We sought to investigate whether visit-to-visit HbA_1c variability is a potential p...

Authors: Chen Die Yang, Ying Shen, Lin Lu, Zhen Kun Yang, Jian Hu, Rui Yan Zhang, Wei Feng Shen, Feng Hua Ding and Xiao Qun Wang

Clinical application of sodium-glucose cotransporter 2 inhibitor into a real-world setting of heart failure care

For years there have been concerns whether the results of large-scale clinical trials that include limited specific patient populations can be applied to patients in real-world clinical practice. Therefore, it...

Authors: Atsushi Tanaka and Koichi Node

Visit-to-visit fasting plasma glucose variability is associated with left ventricular adverse remodeling in diabetic patients with STEMI

Patients with type 2 diabetes mellitus (T2DM) are predisposed to poor cardiovascular outcomes after ST-segment elevation myocardial infarction (STEMI). Left ventricular adverse remodeling (LVAR) triggered upon...

Authors: Chen Die Yang, Ying Shen, Feng Hua Ding, Zhen Kun Yang, Jian Hu, Wei Feng Shen, Rui Yan Zhang, Lin Lu and Xiao Qun Wang

SGLT2 inhibitors and atrial fibrillation in type 2 diabetes: a systematic review with meta-analysis of 16 randomized controlled trials

Type 2 diabetes is closely related to an increased risk of atrial fibrillation (AF) and atrial flutter (AFL). Whether sodium-glucose cotransporter 2 (SGLT2) inhibitors can attenuate AF/AFL progression remains ...

Authors: Wen-jie Li, Xing-qing Chen, Ling-ling Xu, Yuan-qing Li and Bi-hui Luo

Pericardial fat and its influence on cardiac diastolic function

Pericardial fat (PF) has been suggested to directly act on cardiomyocytes, leading to diastolic dysfunction. The aim of this study was to investigate whether a higher PF volume is associated with a lower diast...

Authors: Vera H. W. de Wit-Verheggen, Sibel Altintas, Romy J. M. Spee, Casper Mihl, Sander M. J. van Kuijk, Joachim E. Wildberger, Vera B. Schrauwen-Hinderling, Bas L. J. H. Kietselaer and Tineke van de Weijer

Efficacy and safety of bempedoic acid for prevention of cardiovascular events and diabetes: a systematic review and meta-analysis

Bempedoic acid is an oral, once-daily, first-in-class drug being developed for the treatment of hyperlipidemia. However, evidence of bempedoic acid use for the prevention of cardiovascular events and diabetes ...

Authors: Xing Wang, Yu Zhang, Huiwen Tan, Peng Wang, Xi Zha, Weelic Chong, Liangxue Zhou and Fang Fang

Omega-3 polyunsaturated fatty acid supplementation versus placebo on vascular health, glycaemic control, and metabolic parameters in people with type 1 diabetes: a randomised controlled preliminary trial

The role of omega-3 polyunsaturated fatty acids (n-3PUFA), and the potential impact of n-3PUFA supplementation, in the treatment and management of type 1 diabetes (T1D) remains unclear and controversial. There...

Authors: Lauren L. O’Mahoney, Gareth Dunseath, Rachel Churm, Mel Holmes, Christine Boesch, Antonios Stavropoulos-Kalinoglou, Ramzi A. Ajjan, Karen M. Birch, Nicolas M. Orsi, Georgia Mappa, Oliver J. Price and Matthew D. Campbell

Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles

Lipoprotein disturbances have been associated with increased cardiovascular disease (CVD) risk in type 1 diabetes mellitus (T1DM). We assessed the advanced lipoprotein profile in T1DM individuals, and analysed...

Authors: Antonio J. Amor, Esmeralda Castelblanco, Marta Hernández, Marga Gimenez, Minerva Granado-Casas, Jesús Blanco, Berta Soldevila, Enric Esmatjes, Ignacio Conget, Nuria Alonso, Emilio Ortega and Didac Mauricio

Elevated levels of adiponectin associated with major adverse cardiovascular and cerebrovascular events and mortality risk in ischemic stroke

Adiponectin plays role in multiple metabolic pathways. Previous studies in cardiovascular disease evaluated the association between adiponectin and clinical outcomes, yielding conflicting results. The aim of t...

Authors: Wen-Jun Tu, Han-Cheng Qiu, Ya-Kun Liu, Qiang Liu, Xianwei Zeng and Jizong Zhao

Metformin treatment in heart failure with preserved ejection fraction: a systematic review and meta-regression analysis

Observational series suggest a mortality benefit from metformin in the heart failure (HF) population. However, the benefit of metformin in HF with preserved ejection fraction (HFpEF) has yet to be explored. We...

Authors: Amera Halabi, Jonathan Sen, Quan Huynh and Thomas H. Marwick

Ferritin modifies the relationship between inflammation and arterial stiffness in hypertensive patients with different glucose tolerance

Ferritin, a crucial element for iron homeostasis, is associated with chronic diseases characterized by subclinical inflammation such as essential arterial hypertension and type 2 diabetes mellitus (T2DM), show...

Authors: Angela Sciacqua, Ettore Ventura, Giovanni Tripepi, Velia Cassano, Graziella D’Arrigo, Stefanos Roumeliotis, Raffale Maio, Sofia Miceli, Maria Perticone, Francesco Andreozzi, Giorgio Sesti and Francesco Perticone

Patients with type 2 diabetes present with multiple anomalies of the pancreatic arterial tree on abdominal computed tomography: comparison between patients with type 2 diabetes and a matched control group

Studies suggest that cardio-vascular risk factors could foster the development of type 2 diabetes (T2D). This could partly be mediated by pancreatic atherosclerosis resulting in pancreatic ischemia. We hypothe...

Authors: Laure Alexandre-Heymann, Matthias Barral, Anthony Dohan and Etienne Larger

Predictive values of ANGPTL8 on risk of all-cause mortality in diabetic patients: results from the REACTION Study

Angiopoietin-like protein 8 (ANGPTL8), an important regulator of lipid metabolism, is increased in diabetes and is associated with insulin resistance. However, the role of ANGPTL8 in the outcomes of diabetic p...

Authors: Huajie Zou, Yongping Xu, Xi Chen, Ping Yin, Danpei Li, Wenjun Li, Junhui Xie, Shiying Shao, Liegang Liu and Xuefeng Yu

Growth differentiation factor-15 is associated with cardiovascular outcomes in patients with coronary artery disease

Growth differentiation factor-15 (GDF-15) is a marker of inflammation, oxidative stress and it is associated with adverse prognosis in cardiovascular disease. The aim of the present cohort study is to investig...

Authors: Man Li, Lei Duan, Yu-Lun Cai, Hui-Ying Li, Ben-Chuan Hao, Jian-Qiao Chen and Hong-Bin Liu

Long term clinical impact of successful recanalization of chronic total occlusion in patients with and without type 2 diabetes mellitus

Diabetes mellitus is one of the risk factors for coronary artery disease and frequently associated with multivessels disease and poor clinical outcomes. Long term outcome of successful revascularization of chr...

Authors: Chuan-Tsai Tsai, Wei-Chieh Huang, Hsin-I Teng, Yi-Lin Tsai and Tse-Min Lu

Associations between abdominal obesity indices and diabetic complications: Chinese visceral adiposity index and neck circumference

Obesity, especially abdominal obesity, has been considered a risk factor for diabetic complications. Many abdominal obesity indices have been established, including neck circumference (NC), waist-to-hip ratio ...

Authors: Heng Wan, Yuying Wang, Qian Xiang, Sijie Fang, Yi Chen, Chi Chen, Wen Zhang, Haojie Zhang, Fangzhen Xia, Ningjian Wang and Yingli Lu

The adipokine fatty-acid binding protein 4 and cardiac remodeling

Previous publications about the association between fatty-acid binding protein 4 (FABP4) and cardiac remodeling have reported different, both beneficial and harmful, associations. Aim of the present investigat...

Authors: Beatrice von Jeinsen, Lisa Ritzen, Julia Vietheer, Claudia Unbehaun, Maren Weferling, Christoph Liebetrau, Christian W. Hamm, Andreas Rolf and Till Keller

Discordance between the triglyceride glucose index and fasting plasma glucose or HbA1C in patients with acute coronary syndrome undergoing percutaneous coronary intervention predicts cardiovascular events: a cohort study from China

Previous studies have investigated the relationship of the triglyceride glucose (TyG) index with the incidence of cardiovascular events. However, to date, there have been no studies comparing the predictive va...

Authors: Chengping Hu, Jianwei Zhang, Jinxing Liu, Yan Liu, Ang Gao, Yong Zhu and Yingxin Zhao

Treating type 2 diabetes in COVID-19 patients: the potential benefits of injective therapies

The coronavirus disease 2019 (COVID-19) has been declared as pandemic by the World Health Organization and is causing substantial morbidity and mortality all over the world. Type 2 diabetes, hypertension, and ...

Authors: Miriam Longo, Paola Caruso, Maria Ida Maiorino, Giuseppe Bellastella, Dario Giugliano and Katherine Esposito

Issues for the management of people with diabetes and COVID-19 in ICU

In the pandemic “Corona Virus Disease 2019” (COVID-19) people with diabetes have a high risk to require ICU admission. The management of diabetes in Intensive Care Unit is always challenging, however, when dia...

Authors: Antonio Ceriello, Eberhard Standl, Doina Catrinoiu, Baruch Itzhak, Nebojsa M. Lalic, Dario Rahelic, Oliver Schnell, Jan Škrha and Paul Valensi

Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry

The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using s...

Authors: Ki-Bum Won, Byoung Kwon Lee, Hyung-Bok Park, Ran Heo, Sang-Eun Lee, Asim Rizvi, Fay Y. Lin, Amit Kumar, Martin Hadamitzky, Yong-Jin Kim, Ji Min Sung, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J. Budoff, Ilan Gottlieb…

A high triglyceride glucose index is more closely associated with hypertension than lipid or glycemic parameters in elderly individuals: a cross-sectional survey from the Reaction Study

Both lipid and glucose abnormalities are associated with hypertension (HTN). However, it is unclear whether the triglyceride-glucose (TyG) index is associated with HTN. Therefore the aim of this study is to in...

Authors: Binruo Zhu, Jie Wang, Kang Chen, Wenhua Yan, Anping Wang, Weiqing Wang, Zhengnan Gao, Xulei Tang, Li Yan, Qin Wan, Zuojie Luo, Guijun Qin, Lulu Chen and Yiming Mu

Lipoprotein (a) predicts recurrent worse outcomes in type 2 diabetes mellitus patients with prior cardiovascular events: a prospective, observational cohort study

Merging studies have reported the association of lipoprotein(a) [Lp(a)] with poor outcomes of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). However, the prognostic importance ...

Authors: Yan Zhang, Jing-Lu Jin, Ye-Xuan Cao, Hui-Wen Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Ying Gao, Qi Hua, Yan-Fang Li, Rui-Xia Xu and Jian-Jun Li

Tofogliflozin does not delay progression of carotid atherosclerosis in patients with type 2 diabetes: a prospective, randomized, open-label, parallel-group comparative study

This study aimed to investigate the preventive effects of tofogliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, on atherosclerosis progression in type 2 diabetes (T2DM) patients without ...

Authors: Naoto Katakami, Tomoya Mita, Hidenori Yoshii, Toshihiko Shiraiwa, Tetsuyuki Yasuda, Yosuke Okada, Keiichi Torimoto, Yutaka Umayahara, Hideaki Kaneto, Takeshi Osonoi, Tsunehiko Yamamoto, Nobuichi Kuribayashi, Kazuhisa Maeda, Hiroki Yokoyama, Keisuke Kosugi, Kentaro Ohtoshi…

The association between glucose-related variables and plaque morphology in patients with ST-segment elevated myocardial infarction

Plaque rupture (PR) and plaque erosion (PE) are main causes of acute myocardial infarction with different demographic and histology characteristics and need different treatment strategy. PR and PE can be ident...

Authors: Jinxin Liu, Shanjie Wang, Can Cui, Hengxuan Cai, Rong Sun, Weili Pan, Shaohong Fang and Bo Yu

Impacts of triglyceride-glucose index on prognosis of patients with type 2 diabetes mellitus and non-ST-segment elevation acute coronary syndrome: results from an observational cohort study in China

The relationship between triglyceride-glucose index (TyG index) and the prevalence and prognosis of cardiovascular disease has been confirmed by former studies. However, it remains uncertain whether TyG index ...

Authors: Qi Zhao, Ting-Yu Zhang, Yu-Jing Cheng, Yue Ma, Ying-Kai Xu, Jia-Qi Yang and Yu-Jie Zhou

Add-on therapy in metformin-treated patients with type 2 diabetes at moderate cardiovascular risk: a nationwide study

In randomised clinical trials, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium–glucose cotransporter 2 (SGLT-2) inhibitors reduced cardiovascular events in patients with type 2 diabetes (T2D) ...

Authors: David Thein, Mia Nielsen Christiansen, Ulrik Madvig Mogensen, Johan Skov Bundgaard, Rasmus Rørth, Christian Madelaire, Emil Loldrup Fosbøl, Morten Schou, Christian Torp-Pedersen, Gunnar Gislason, Lars Køber and Søren Lund Kristensen

Liraglutide in the treatment of heart failure: insight from FIGHT and LIVE

There are many glucose-lowering agents used in patients with heart failure, showing mixed results, this study was conducted to determine the effect of liraglutide, a glucagon-like peptide-1 analogue, on the tr...

Authors: Bo Liang and Ning Gu

Comparative predictive ability of visit-to-visit HbA1c variability measures for microvascular disease risk in type 2 diabetes

To assess the associations of various HbA1c measures, including a single baseline HbA1c value, overall mean, yearly updated means, standard deviation (HbA1c-SD), coefficient of variation (HbA1c-CV), and HbA1c ...

Authors: Chen-Yi Yang, Pei-Fang Su, Jo-Ying Hung, Huang-Tz Ou and Shihchen Kuo

The longitudinal association of remnant cholesterol with cardiovascular outcomes in patients with diabetes and pre-diabetes

The atherogenicity of remnant cholesterol (RC) has been underlined by recent guidelines, which was linked to coronary artery disease (CAD), especially for patients with diabetes mellitus (DM). This study aimed...

Authors: Ye-Xuan Cao, Hui-Wen Zhang, Jing-Lu Jin, Hui-Hui Liu, Yan Zhang, Ying Gao, Yuan-Lin Guo, Na-Qiong Wu, Qi Hua, Yan-Fang Li, Xiao-Lin Li, Rui-Xia Xu, Chuan-Jue Cui, Geng Liu, Qian Dong, Jing Sun…

Prior bariatric surgery and perioperative cardiovascular outcomes following noncardiac surgery in patients with type 2 diabetes mellitus: hint from National Inpatient Sample Database

Both diabetes and obesity are risk factors for perioperative major adverse events. This study aims to evaluate the association between prior bariatric surgery (prior-BS) and perioperative cardiovascular outcom...

Authors: Jiewen Jin, Zhantao Deng, Lijuan Xu, Hai Li, Pengyuan Zhang, Liehua Liu, Juan Liu, Hedong Han, Zhimin Huang, Xiaopei Cao, Haipeng Xiao and Yanbing Li

Glycemic variability: adverse clinical outcomes and how to improve it?

Glycemic variability (GV), defined as an integral component of glucose homoeostasis, is emerging as an important metric to consider when assessing glycemic control in clinical practice. Although it remains yet...

Authors: Zheng Zhou, Bao Sun, Shiqiong Huang, Chunsheng Zhu and Meng Bian

Augmented glycaemic gap is a marker for an increased risk of post-infarct left ventricular systolic dysfunction

Left ventricular systolic dysfunction (LVSD) occurs frequently after acute ST-segment elevation myocardial infarction (STEMI). The predisposing factors and underlying mechanism of post-infarct LVSD are not ful...

Authors: Yong Zhu, Kesen Liu, Shuai Meng, Ruofei Jia, Xuan Lei, Maolin Chen, Kaiyuan Zou, Huagang Zhu and Zening Jin

Long-term outcomes of medical therapy versus successful recanalisation for coronary chronic total occlusions in patients with and without type 2 diabetes mellitus

In this study, we compared the outcomes of medical therapy (MT) with successful percutaneous coronary intervention (PCI) in chronic total occlusions (CTO) patients with and without type 2 diabetes mellitus.

Authors: Lei Guo, Junjie Wang, Huaiyu Ding, Shaoke Meng, Xiaoyan Zhang, Haichen Lv, Lei Zhong, Jian Wu, Jiaying Xu, Xuchen Zhou and Rongchong Huang

Cardiovascular and diabetes burden attributable to physical inactivity in Mexico

Physical inactivity (PI) is associated with the development of non-communicable chronic diseases. The purposes of this study were to estimate the extent to which the 31% relative increase in PI among 35–64 yea...

Authors: Catalina Medina, Pamela Coxson, Joanne Penko, Ian Janssen, Sergio Bautista-Arredondo, Simón Barquera and Kirsten Bibbins-Domingo

SGLT2i: beyond the glucose-lowering effect

Sodium/glucose cotransporter-2 inhibitors (SGLT2i) are a new type of glucose-lowering drug that can reduce blood glucose by inhibiting its reabsorption in proximal tubules and by promoting urinary glucose excr...

Authors: Lihua Ni, Cheng Yuan, Guopeng Chen, Changjiang Zhang and Xiaoyan Wu

Influence of preprocedural glycemic control on clinical outcomes of endovascular therapy in diabetic patients with lower extremity artery disease: an analysis from a Korean multicenter retrospective registry cohort

The influence of intensive glucose control in diabetic patients on the macrovascular outcomes is controversial. Thus, this study aimed to elucidate the effect of preprocedural hemoglobin A1c (HbA1c) on clinica...

Authors: Jung-Joon Cha, Hyoeun Kim, Young-Guk Ko, Donghoon Choi, Jae-Hwan Lee, Chang-Hwan Yoon, In-Ho Chae, Cheol Woong Yu, Seung Whan Lee, Sang-Rok Lee, Seung Hyuk Choi, Yoon Seok Koh and Pil-Ki Min

Indirect comparison of glucagon like peptide-1 receptor agonists regarding cardiovascular safety and mortality in patients with type 2 diabetes mellitus: network meta-analysis

The cardiovascular outcome trials (CVOTs) have shown that glucagon like peptide-1 receptor agonists (GLP1RAs) have varying degrees of cardiovascular (CV) safety in patients with type 2 diabetes mellitus (T2DM....

Authors: Osamah M. Alfayez, Omar A. Almohammed, Omar S. Alkhezi, Abdulaali R. Almutairi and Majed S. Al Yami

Comparison of heart failure risk and medical costs between patients with type 2 diabetes mellitus treated with dapagliflozin and dipeptidyl peptidase-4 inhibitors: a nationwide population-based cohort study

Dapagliflozin is one of the novel glucose-lowering agents, which has recently been reported to reduce the risk of hospitalization for heart failure (hHF). The present study aimed to compare the differences bet...

Authors: Jong-Mi Seong, Jong Joo Kim, Hae Jin Kim and Hyun Soon Sohn