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  1. Content type: Original investigation

    Glycosuria produced by sodium–glucose co-transporter-2 (SGLT-2) inhibitors is associated with weight loss. SGLT-2 inhibitors reportedly might reduce the occurrence of cardiovascular events. Epicardial adipose ...

    Authors: Takao Sato, Yoshifusa Aizawa, Sho Yuasa, Shohei Kishi, Koichi Fuse, Satoshi Fujita, Yoshio Ikeda, Hitoshi Kitazawa, Minoru Takahashi, Masahito Sato and Masaaki Okabe

    Citation: Cardiovascular Diabetology 2018 17:6

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  2. Content type: Original investigation

    Sodium tissue content by 23Na magnetic resonance imaging (Na-MRI) has been validated in experimental and human studies. SGLT-2 inhibition blocks the reabsorption of glucose and of sodium in the proximal tubular c...

    Authors: M. V. Karg, A. Bosch, D. Kannenkeril, K. Striepe, C. Ott, M. P. Schneider, F. Boemke-Zelch, P. Linz, A. M. Nagel, J. Titze, M. Uder and R. E. Schmieder

    Citation: Cardiovascular Diabetology 2018 17:5

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  3. Content type: Original investigation

    Cardiac magnetic resonance (CMR) T1 mapping and tissue-tracking strain analysis are useful quantitative techniques that can characterize myocardial tissue and mechanical alterations, respectively, in patients ...

    Authors: Yukun Cao, Wenjuan Zeng, Yue Cui, Xiangchuang Kong, Miao Wang, Jie Yu, Shan Zhang, Jing Song, Xu Yan, Andreas Greiser and Heshui Shi

    Citation: Cardiovascular Diabetology 2018 17:7

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  4. Content type: Original investigation

    The cardiovascular safety and efficacy of linagliptin, a dipeptidyl peptidase-4 inhibitor, in patients with type 2 diabetes mellitus (T2DM) after acute coronary syndrome (ACS) or acute ischemic stroke (AIS) ar...

    Authors: Yan-Rong Li, Sung-Sheng Tsai, Dong-Yi Chen, Szu-Tah Chen, Jui-Hung Sun, Hung-Yu Chang, Miaw-Jene Liou and Tien-Hsing Chen

    Citation: Cardiovascular Diabetology 2018 17:2

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  5. Content type: Commentary

    NG-Methylation of l-arginine (Arg) residues in certain proteins by protein arginine methyltransferases and subsequent proteolysis yields NG-monomethyl-l-arginine (MMA), NG,NG-dimethyl-l-arginine (asymmetric dimet...

    Authors: Dimitrios Tsikas, Alexander Bollenbach, Erik Hanff and Arslan Arinc Kayacelebi

    Citation: Cardiovascular Diabetology 2018 17:1

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  6. Content type: Original investigation

    Data on the influence of glycemic status on the progression of coronary calcification, an important marker for future adverse cardiovascular events, are limited.

    Authors: Ki-Bum Won, Donghee Han, Ji Hyun Lee, Sang-Eun Lee, Ji Min Sung, Su-Yeon Choi, Eun Ju Chun, Sung Hak Park, Hae-Won Han, Jidong Sung, Hae Ok Jung and Hyuk-Jae Chang

    Citation: Cardiovascular Diabetology 2018 17:4

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  7. Content type: Original investigation

    Attenuated increases in ventricular stroke volume during exercise are common in type 2 diabetes and contribute to reduced aerobic capacity. The purpose of this study was to determine whether impaired ventricul...

    Authors: Genevieve A. Wilson, Gerard T. Wilkins, Jim D. Cotter, Regis R. Lamberts, Sudish Lal and James C. Baldi

    Citation: Cardiovascular Diabetology 2017 16:160

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  8. Content type: Original investigation

    Whether dipeptidyl peptidase-4 inhibitor (DPP4i) is associated with a lower risk of new-onset atrial fibrillation (AF) in patients with diabetes remains unclear. This study aimed to evaluate the risk of AF ass...

    Authors: Chia-Yu Chang, Yung-Hsin Yeh, Yi-Hsin Chan, Jia-Rou Liu, Shang-Hung Chang, Hsin-Fu Lee, Lung-Sheng Wu, Kun-Chi Yen, Chi-Tai Kuo and Lai-Chu See

    Citation: Cardiovascular Diabetology 2017 16:159

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  9. Content type: Original investigation

    Elevated levels of low-density lipoprotein cholesterol (LDL-C) and glycosylated hemoglobin (HbA1c) are risk factors for cardiovascular complications. This study evaluated LDL-C goal attainment in Russian clini...

    Authors: Sergey Boytsov, Natalia Logunova and Yunona Khomitskaya

    Citation: Cardiovascular Diabetology 2017 16:158

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  10. Content type: Original investigation

    Hyperglycemia is associated with increased morbidity and mortality in patients with an acute myocardial infarction (AMI). We evaluated whether complications after AMI are associated with absolute or relative g...

    Authors: Tien F. Lee, Morton G. Burt, Leonie K. Heilbronn, Arduino A. Mangoni, Vincent W. Wong, Mark McLean and N. Wah Cheung

    Citation: Cardiovascular Diabetology 2017 16:157

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  11. Content type: Original investigation

    Coronary atherosclerosis progresses faster in patients with diabetes mellitus (DM) and causes higher morbidity and mortality in such patients compared to non-diabetics ones (non-DM). We quantify changes in pla...

    Authors: Tomas Kovarnik, Zhi Chen, Gary S. Mintz, Andreas Wahle, Kristyna Bayerova, Ales Kral, Martin Chval, Karel Kopriva, John Lopez, Milan Sonka and Ales Linhart

    Citation: Cardiovascular Diabetology 2017 16:156

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  12. Content type: Review

    Cardiovascular disease, predominantly ischemic heart disease (IHD), is the leading cause of death in diabetes mellitus (DM). In addition to eliciting cardiomyopathy, DM induces a ‘wicked triumvirate’: (i) incr...

    Authors: Jake Russell, Eugene F. Du Toit, Jason N. Peart, Hemal H. Patel and John P. Headrick

    Citation: Cardiovascular Diabetology 2017 16:155

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  13. Content type: Original investigation

    Patients with type 2 diabetes (T2DM) are at high risk for cardiovascular events, which usually arise from the rupture of a vulnerable coronary plaque. The minimal fibrous cap thickness (FCT) overlying a necrot...

    Authors: Andrea Milzi, Mathias Burgmaier, Kathrin Burgmaier, Martin Hellmich, Nikolaus Marx and Sebastian Reith

    Citation: Cardiovascular Diabetology 2017 16:152

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  14. Content type: Original investigation

    The potential of anti-aging effect of DPP-4 inhibitors is unknown. This study was performed to determine whether linagliptin, a DPP-4 inhibitor, could protect against premature aging in klotho−/− mice.

    Authors: Yu Hasegawa, Kenyu Hayashi, Yushin Takemoto, Cao Cheng, Koki Takane, Bowen Lin, Yoshihiro Komohara and Shokei Kim-Mitsuyama

    Citation: Cardiovascular Diabetology 2017 16:154

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  15. Content type: Original investigation

    Biomarkers of inflammation and adiponectin are associated with cardiovascular autonomic neuropathy (CAN) in cross-sectional studies, but prospective data are scarce. This study aimed to assess the associations...

    Authors: Christian Stevns Hansen, Dorte Vistisen, Marit Eika Jørgensen, Daniel R. Witte, Eric J. Brunner, Adam G. Tabák, Mika Kivimäki, Michael Roden, Marek Malik and Christian Herder

    Citation: Cardiovascular Diabetology 2017 16:153

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  16. Content type: Original investigation

    Diabetes mellitus is considered an important risk factor for cardiovascular diseases. High hemoglobin A1c (HbA1c) levels, which indicate poor glycemic control, have been associated with occurrence of cardiovas...

    Authors: Shohei Ouchi, Kazunori Shimada, Tetsuro Miyazaki, Shuhei Takahashi, Yurina Sugita, Megumi Shimizu, Azusa Murata, Tomoyasu Kadoguchi, Takao Kato, Tatsuro Aikawa, Shoko Suda, Eiryu Sai, Masaru Hiki, Hiroshi Iwata, Takatoshi Kasai, Katsumi Miyauchi…

    Citation: Cardiovascular Diabetology 2017 16:151

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  17. Content type: Correction

    Following publication of the original article [1], the authors identified a number of errors. In Result (P.3), Table 1 (P.4), Table 5 (P.9) and Supplementary Table 1, the correct unit for adiponectin was μg/mL. I...

    Authors: Toshiyuki Hayashi, Tomoyasu Fukui, Noriko Nakanishi, Saki Yamamoto, Masako Tomoyasu, Anna Osamura, Makoto Ohara, Takeshi Yamamoto, Yasuki Ito and Tsutomu Hirano

    Citation: Cardiovascular Diabetology 2017 16:149

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    The original article was published in Cardiovascular Diabetology 2017 16:8

  18. Content type: Original investigation

    The cardiovascular benefits of statins have been proven, but their effect on circulation in small vessels has not been examined fully. We investigated the effect of 20 mg rosuvastatin on biomarkers, including ...

    Authors: Kyoung Min Kim, Kyong Yeun Jung, Han Mi Yun, Seo Young Lee, Tae Jung Oh, Hak Chul Jang and Soo Lim

    Citation: Cardiovascular Diabetology 2017 16:146

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  19. Content type: Original investigation

    Hypoglycemia is associated with increased mortality rate in patients with diabetes. The underlying mechanisms may involve reduced myocardial tolerance to ischemia and reperfusion (IR) or reduced capacity for i...

    Authors: Kim B. Pælestik, Nichlas R. Jespersen, Rebekka V. Jensen, Jacob Johnsen, Hans Erik Bøtker and Steen B. Kristiansen

    Citation: Cardiovascular Diabetology 2017 16:148

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  20. Content type: Original investigation

    Coexistence of left ventricular (LV) longitudinal myocardial systolic dysfunction with LV diastolic dysfunction could lead to heart failure with preserved ejection fraction (HFpEF). Diabetes mellitus (DM) is k...

    Authors: Makiko Suto, Hidekazu Tanaka, Yasuhide Mochizuki, Jun Mukai, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hiroyuki Sano, Hiroyuki Shimoura, Junichi Ooka, Kensuke Matsumoto, Yushi Hirota, Wataru Ogawa…

    Citation: Cardiovascular Diabetology 2017 16:145

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  21. Content type: Original investigation

    Irisin is a hormone released mainly from skeletal muscle after exercise which increases adipose tissue energy expenditure. Adipocytes can also release irisin after exercise, acting as a local adipokine to indu...

    Authors: Karan S. Rana, Chathyan Pararasa, Islam Afzal, David A. Nagel, Eric J. Hill, Clifford J. Bailey, Helen R. Griffiths, Ioannis Kyrou, Harpal S. Randeva, Srikanth Bellary and James E. Brown

    Citation: Cardiovascular Diabetology 2017 16:147

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  22. Content type: Original investigation

    Type 2 diabetes mellitus (T2DM) is strongly related to the in-hospital and short-term prognosis in patients with cardiovascular diseases needing surgical or invasive interventions. How T2DM might influence the...

    Authors: Manuel Mendez-Bailon, Noel Lorenzo-Villalba, Nuria Muñoz-Rivas, Jose Maria de Miguel-Yanes, Javier De Miguel-Diez, Josep Comín-Colet, Valentin Hernandez-Barrera, Rodrigo Jimenez-Garcia and Ana Lopez-de-Andres

    Citation: Cardiovascular Diabetology 2017 16:144

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  23. Content type: Original investigation

    Macrophages play a pivotal role in atherosclerotic plaque development. Recent evidence has suggested the glucagon-like peptide-1 receptor (GLP-1R) agonist, liraglutide, can attenuate pro-inflammatory responses...

    Authors: Robyn Bruen, Sean Curley, Sarina Kajani, Daniel Crean, Marcella E. O’Reilly, Margaret B. Lucitt, Catherine G. Godson, Fiona C. McGillicuddy and Orina Belton

    Citation: Cardiovascular Diabetology 2017 16:143

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  24. Content type: Original investigation

    Diabetes mellitus is a risk factor for coronary artery disease and diabetic cardiomyopathy, and adversely impacts outcomes following coronary artery bypass grafting. Current treatments focus on macro-revascula...

    Authors: Masashi Kawamura, Michael J. Paulsen, Andrew B. Goldstone, Yasuhiro Shudo, Hanjay Wang, Amanda N. Steele, Lyndsay M. Stapleton, Bryan B. Edwards, Anahita Eskandari, Vi N. Truong, Kevin J. Jaatinen, Arnar B. Ingason, Shigeru Miyagawa, Yoshiki Sawa and Y. Joseph Woo

    Citation: Cardiovascular Diabetology 2017 16:142

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  25. Content type: Original investigation

    We have previously shown that many chronic, inflammatory diseases are accompanied, and possibly partly caused or exacerbated, by various coagulopathies, manifested as anomalous clots in the form of ‘dense matt...

    Authors: Etheresia Pretorius, Martin J. Page, Lize Engelbrecht, Graham C. Ellis and Douglas B. Kell

    Citation: Cardiovascular Diabetology 2017 16:141

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  26. Content type: Original investigation

    Pioglitazone (PIO), a thiazolidinediones drug, is a well-known anti-diabetic medicine, but its anti-atherosclerotic effects remain controversial. Thus it is important to investigate the effects of PIO on ather...

    Authors: Yuling Tian, Tao Chen, Yan Wu, Lin Yang, Lijun Wang, Xiaojuan Fan, Wei Zhang, Jiahao Feng, Hang Yu, Yanjie Yang, Juan Zhou, Zuyi Yuan and Yue Wu

    Citation: Cardiovascular Diabetology 2017 16:140

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  27. Content type: Original investigation

    Altered regulation of extracellular matrix (ECM) composition by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinase (TIMPs) may contribute to arterial stiffening. We investigated associ...

    Authors: Stijn A. Peeters, Lian Engelen, Jacqueline Buijs, Nish Chaturvedi, John H. Fuller, Anders Jorsal, Hans-Henrik Parving, Lise Tarnow, Simone Theilade, Peter Rossing, Casper G. Schalkwijk and Coen D. A. Stehouwer

    Citation: Cardiovascular Diabetology 2017 16:139

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  28. Content type: Original investigation

    Sodium-glucose cotransporter-2 inhibitors reduce blood pressure (BP) and renal and cardiovascular events in patients with type 2 diabetes through not fully elucidated mechanisms. Aim of this study was to inves...

    Authors: Anna Solini, Livia Giannini, Marta Seghieri, Edoardo Vitolo, Stefano Taddei, Lorenzo Ghiadoni and Rosa Maria Bruno

    Citation: Cardiovascular Diabetology 2017 16:138

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  29. Content type: Review

    These recommendations aim to improve care for patients with type 2 diabetes (T2D) at high cardiovascular (CV) risk in Central and Eastern Europe. Cardiovascular disease (CVD) and/or chronic kidney disease (CKD...

    Authors: Guntram Schernthaner, Roger Lehmann, Martin Prázný, Leszek Czupryniak, Kristine Ducena, Peter Fasching, Andrej Janež, Avraham Karasik, Peter Kempler, Emil Martinka, Marina V. Shestakova, Lea Smirčić Duvnjak and Tsvetalina Tankova

    Citation: Cardiovascular Diabetology 2017 16:137

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  30. Content type: Correction

    This article was unintentionally published twice in this journal, by the same authors. The following should be considered the version of record and used for citation purposes: “Mehran Haidari, Wei Zhang, James...

    Authors: Mehran Haidari, Wei Zhang, James T. Willerson and Richard A. F. Dixon

    Citation: Cardiovascular Diabetology 2017 16:136

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    The original article was published in Cardiovascular Diabetology 2014 13:112

  31. Content type: Correction

    Following publication of the original article [1], author Antonio Ceriello requested that a correction be published in relation to his affiliations. His correct affiliations have been updated in this erratum. Thi...

    Authors: Oliver Schnell, Eberhard Standl, Doina Catrinoiu, Stefano Genovese, Nebojsa Lalic, Jan Skra, Paul Valensi, Dario Rahelic and Antonio Ceriello

    Citation: Cardiovascular Diabetology 2017 16:135

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    The original article was published in Cardiovascular Diabetology 2017 16:35

  32. Content type: Original investigation

    Previous studies have demonstrated that secreted frizzled-related protein 4 (SFRP4) is associated with impaired glucose and triglyceride metabolism in patients with stable coronary artery disease. In the prese...

    Authors: Qingwei Ji, Jianwei Zhang, Yu Du, Enjun Zhu, Zhijian Wang, Bin Que, Huangtai Miao, Shutian Shi, Xiuchuan Qin, Yingxin Zhao, Yujie Zhou, Fangjun Huang and Shaoping Nie

    Citation: Cardiovascular Diabetology 2017 16:133

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  33. Content type: Review

    Pioglitazone targets multiple pathogenic pathways involved in the development of cardiovascular diseases (CVD). The aim of this systematic review and meta-analysis is to assess the effects of pioglitazone trea...

    Authors: Marit de Jong, H. Bart van der Worp, Yolanda van der Graaf, Frank L. J. Visseren and Jan Westerink

    Citation: Cardiovascular Diabetology 2017 16:134

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  34. Content type: Original investigation

    Functional properties of high density lipoproteins (HDL) are increasingly recognized to play a physiological role in atheroprotection. Type 2 diabetes mellitus (T2DM) is characterized by low HDL cholesterol, b...

    Authors: Sanam Ebtehaj, Eke G. Gruppen, Mojtaba Parvizi, Uwe J. F. Tietge and Robin P. F. Dullaart

    Citation: Cardiovascular Diabetology 2017 16:132

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  35. Content type: Original investigation

    Both the progression of diabetic kidney disease and increased glycemic variability play important roles in the pathogenesis of coronary plaque formation via inflammatory pathways in patients with type 2 diabet...

    Authors: Kentaro Kakuta, Kaoru Dohi, Miho Miyoshi, Takashi Yamanaka, Masaki Kawamura, Jun Masuda, Tairo Kurita, Toru Ogura, Norikazu Yamada, Yasuhiro Sumida and Masaaki Ito

    Citation: Cardiovascular Diabetology 2017 16:131

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  36. Content type: Study Protocol

    Asymptomatic left ventricular (LV) dysfunction is highly prevalent in type 2 diabetes patients. Unlike the other hypoglycemic drugs, SGLT2 inhibitors have shown potential benefits for reducing cardiovascular d...

    Authors: Andrea Natali, Lorenzo Nesti, Iacopo Fabiani, Enrico Calogero and Vitantonio Di Bello

    Citation: Cardiovascular Diabetology 2017 16:130

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  37. Content type: Review

    In 2008 the Food and Drug Administration introduced a guidance for industry that requires the investigation of cardiovascular outcomes of glucose-lowering medications. Since then, an increasing number of cardi...

    Authors: Oliver Schnell, Lars Rydén, Eberhard Standl and Antonio Ceriello

    Citation: Cardiovascular Diabetology 2017 16:128

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    The Correction to this article has been published in Cardiovascular Diabetology 2017 16:150

  38. Content type: Original investigation

    Dipeptidyl peptidase-4 (DPP-4) inhibitors may have protective effects in the early stage of atherosclerosis in patients with type 2 diabetes, although similar effects in advanced atherosclerosis were not shown...

    Authors: Naoyuki Kitao, Hideaki Miyoshi, Tomoo Furumoto, Kota Ono, Hiroshi Nomoto, Aika Miya, Chiho Yamamoto, Atsushi Inoue, Kenichi Tsuchida, Naoki Manda, Yoshio Kurihara, Shin Aoki, Akinobu Nakamura and Tatsuya Atsumi

    Citation: Cardiovascular Diabetology 2017 16:125

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  39. Content type: Original investigation

    We investigated whether glycated albumin (GA) and its variability are associated with cardiovascular autonomic neuropathy (CAN) and further compared their associations with glycated hemoglobin (HbA1c).

    Authors: Ji Eun Jun, Seung-Eun Lee, You-Bin Lee, Ji Yeon Ahn, Gyuri Kim, Sang-Man Jin, Kyu Yeon Hur, Moon-Kyu Lee and Jae Hyeon Kim

    Citation: Cardiovascular Diabetology 2017 16:127

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  40. Content type: Original investigation

    Diabetes mellitus has long been associated with cardiovascular events. Nevertheless, the higher burden of traditional cardiovascular risk factors reported in high-income countries is offset by a more widesprea...

    Authors: José M. de Miguel-Yanes, Rodrigo Jiménez-García, Valentín Hernández-Barrera, Manuel Méndez-Bailón, Javier de Miguel-Díez and Ana Lopez-de-Andrés

    Citation: Cardiovascular Diabetology 2017 16:126

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  41. Content type: Review

    Despite best evidence-based treatment including statins, residual cardiovascular risk poses a major challenge for clinicians in the twenty first century. Atherogenic dyslipidaemia, in particular elevated trigl...

    Authors: Jean-Charles Fruchart

    Citation: Cardiovascular Diabetology 2017 16:124

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  42. Content type: Original investigation

    Previous animal studies have shown that glucagon-like peptide-1 receptor agonists (GLP-1RAs) suppress arterial restenosis, a major complication of angioplasty, presumably through their direct action on vascula...

    Authors: Hideki Kushima, Yusaku Mori, Masakazu Koshibu, Munenori Hiromura, Kyoko Kohashi, Michishige Terasaki, Tomoyasu Fukui and Tsutomu Hirano

    Citation: Cardiovascular Diabetology 2017 16:122

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  43. Content type: Original investigation

    The low-density lipoprotein cholesterol/apolipoprotein B (LDL-C/apoB) ratio has conventionally been used as an index of the LDL-particle size. Smaller LDL-particle size is associated with triglyceride (TG) met...

    Authors: Shigemasa Tani, Tsukasa Yagi, Wataru Atsumi, Kenji Kawauchi, Rei Matsuo and Atsushi Hirayama

    Citation: Cardiovascular Diabetology 2017 16:123

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  44. Content type: Review

    Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several risk factors promote AF, among which diabetes mellitus has emerged as one of the most important. The growing recognit...

    Authors: Basil S. Karam, Alejandro Chavez-Moreno, Wonjoon Koh, Joseph G. Akar and Fadi G. Akar

    Citation: Cardiovascular Diabetology 2017 16:120

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  45. Content type: Original investigation

    Abnormalities of endothelial cell function are proposed to be a critical factor underlying adverse cardiovascular outcomes in the setting of hyperglycaemia. While high-density lipoproteins (HDL) have been demo...

    Authors: Xing Chen, My-Ngan Duong, Peter J. Psaltis, Christina A. Bursill and Stephen J. Nicholls

    Citation: Cardiovascular Diabetology 2017 16:121

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  46. Content type: Original investigation

    NTproBNP and BNP levels are reduced in obese subjects, but population-based data comparing the pattern of this relationship in the full spectrum of insulin-resistance mediated conditions, overweight/obesity, m...

    Authors: Stefano Baldassarre, Salvatore Fragapani, Antonio Panero, Debora Fedele, Silvia Pinach, Manuela Lucchiari, Anna Rita Vitale, Giulio Mengozzi, Gabriella Gruden and Graziella Bruno

    Citation: Cardiovascular Diabetology 2017 16:119

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  47. Content type: Original investigation

    Microparticles (MPs) are vesicular structures shed from endothelial or circulating blood cells, after activation or apoptosis, and can be considered markers of vascular damage. We aimed to determine the levels...

    Authors: Alessandra Giannella, Claudia Maria Radu, Lorenzo Franco, Elena Campello, Paolo Simioni, Angelo Avogaro, Saula Vigili de Kreutzenberg and Giulio Ceolotto

    Citation: Cardiovascular Diabetology 2017 16:118

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  48. Content type: Erratum

    Following publication of the original article [1], the authors reported that figure 2 had not been replaced with the correct figure as indicated in the proofs.

    Authors: Anxin Wang, Yang Sun, Xiaoxue Liu, Zhaoping Su, Junjuan Li, Yanxia Luo, Shuohua Chen, Jianli Wang, Xia Li, Zhan Zhao, Huiping Zhu, Shouling Wu and Xiuhua Guo

    Citation: Cardiovascular Diabetology 2017 16:117

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    The original article was published in Cardiovascular Diabetology 2017 16:104

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