Eckel RH, Grundy SM, Zimmet PZ: The metabolic syndrome. Lancet. 2005, 365 (9468): 1415-1428. 10.1016/S0140-6736(05)66378-7.
Article
CAS
PubMed
Google Scholar
Hotamisligil GS: Inflammation and metabolic disorders. Nature. 2006, 444 (7121): 860-867. 10.1038/nature05485.
Article
CAS
PubMed
Google Scholar
Sutherland JP, McKinley B, Eckel RH: The metabolic syndrome and inflammation. Metab Syndr Relat Disord. 2004, 2 (2): 82-104. 10.1089/met.2004.2.82.
Article
CAS
PubMed
Google Scholar
Povel CM, Boer JMA, Reiling E, Feskens EJM: Genetic variants and the metabolic syndrome: a systematic review. Obes Rev. 2011, 12 (11): 952-967. 10.1111/j.1467-789X.2011.00907.x.
Article
CAS
PubMed
Google Scholar
Kraja AT, Vaidya D, Pankow JS, Goodarzi MO, Assimes TL, Kullo IJ, Sovio U, Mathias RA, Sun YV, Franceschini N, et al: A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium. Diabetes. 2011, 60 (4): 1329-1339. 10.2337/db10-1011.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bosy-Westphal A, Onur S, Geisler C, Wolf A, Korth O, Pfeufferm M, Schrezenmeir J, Krawczak M, Muller MJ: Common familial influences on clustering of metabolic syndrome traits with central obesity and insulin resistance: the Kiel obesity prevention study. Int J Obes (Lond). 2007, 31 (5): 784-790.
CAS
Google Scholar
Goeman JJ, van de Geer SA, de Kort F, van Houwelingen HC: A global test for groups of genes: testing association with a clinical outcome. Bioinformatics. 2004, 20 (1): 93-99. 10.1093/bioinformatics/btg382.
Article
CAS
PubMed
Google Scholar
Beulens JW, Monninkhof EM, Verschuren WM, van der Schouw YT, Smit J, Ocke MC, Jansen EH, van Dieren S, Grobbee DE, Peeters PH, et al: Cohort profile: the EPIC-NL study. Int J Epidemiol. 2010, 39 (5): 1170-1178. 10.1093/ije/dyp217.
Article
PubMed
Google Scholar
Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC, et al: Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Executive summary. Cardiol Rev. 2005, 13 (6): 322-327.
PubMed
Google Scholar
American Diabetes Association: Standards of medical care in diabetes–2010. Diabetes. 2010, 33 (Suppl 1): S11-S61.
Google Scholar
American Diabetes Association: Diagnosis and classification of diabetes mellitus. Diabetes. 2010, 33 (Suppl 1): S62-S69.
Google Scholar
Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, Glessner JT, Galver L, Barrett JC, Grant SF, Farlow DN, et al: Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One. 2008, 3 (10): e3583-10.1371/journal.pone.0003583.
Article
PubMed Central
PubMed
Google Scholar
Bauer F, Elbers CC, Adan RA, Loos RJ, Onland-Moret NC, Grobbee DE, van Vliet-Ostaptchouk JV, Wijmenga C, van der Schouw YT: Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am J Clin Nutr. 2009, 90 (4): 951-959. 10.3945/ajcn.2009.27781.
Article
CAS
PubMed
Google Scholar
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, et al: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat. 2010, 42 (2): 105-116. 10.1038/ng.520.
CAS
Google Scholar
Rung J, Cauchi S, Albrechtsen A, Shen L, Rocheleau G, Cavalcanti-Proenca C, Bacot F, Balkau B, Belisle A, Borch-Johnsen K, et al: Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet. 2009, 41 (10): 1110-1115. 10.1038/ng.443. Epub 2009 Sep 1116
Article
CAS
PubMed
Google Scholar
Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM, et al: Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet. 2009, 5 (6): e1000508-10.1371/journal.pgen.1000508.
Article
PubMed Central
PubMed
Google Scholar
Elliott P, Chambers JC, Zhang W, Clarke R, Hopewell JC, Peden JF, Erdmann J, Braund P, Engert JC, Bennett D, et al: Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA. 2009, 302 (1): 37-48. 10.1001/jama.2009.954.
Article
PubMed Central
CAS
PubMed
Google Scholar
Richards JB, Waterworth D, O’Rahilly S, Hivert MF, Loos RJ, Perry JR, Tanaka T, Timpson NJ, Semple RK, Soranzo N, et al: A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet. 2009, 5 (12): e1000768-10.1371/journal.pgen.1000768.
Article
PubMed Central
PubMed
Google Scholar
He M, Cornelis MC, Kraft P, van Dam RM, Sun Q, Laurie CC, Mirel DB, Chasman DI, Ridker PM, Hunter DJ, et al: Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels. Arterioscler. 2010, 30 (4): 885-890. 10.1161/ATVBAHA.109.199422.
Article
CAS
Google Scholar
Ridker PM, Pare G, Parker A, Zee RY, Danik JS, Buring JE, Kwiatkowski D, Cook NR, Miletich JP, Chasman DI: Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women’s Genome Health Study. Am J Hum Genet. 2008, 82 (5): 1185-1192. 10.1016/j.ajhg.2008.03.015. Epub 2008 Apr 1124
Article
PubMed Central
CAS
PubMed
Google Scholar
Waterworth DM, Ricketts SL, Song K, Chen L, Zhao JH, Ripatti S, Aulchenko YS, Zhang W, Yuan X, Lim N, et al: Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol. 2010, 30 (11): 2264-2276. 10.1161/ATVBAHA.109.201020.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sabatti C, Service SK, Hartikainen AL, Pouta A, Ripatti S, Brodsky J, Jones CG, Zaitlen NA, Varilo T, Kaakinen M, et al: Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet. 2009, 41 (1): 35-46. 10.1038/ng.271.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kathiresan S, Melander O, Guiducci C, Surti A, Burtt NP, Rieder MJ, Cooper GM, Roos C, Voight BF, Havulinna AS, et al: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet. 2008, 40 (2): 189-197. 10.1038/ng.75.
Article
PubMed Central
CAS
PubMed
Google Scholar
Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, Heath SC, Timpson NJ, Najjar SS, Stringham HM, et al: Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet. 2008, 40 (2): 161-169. 10.1038/ng.76.
Article
CAS
PubMed
Google Scholar
Wallace C, Newhouse SJ, Braund P, Zhang F, Tobin M, Falchi M, Ahmadi K, Dobson RJ, Marcano AC, Hajat C, et al: Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet. 2008, 82 (1): 139-149. 10.1016/j.ajhg.2007.11.001.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T, et al: Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet. 2009, 41 (1): 56-65. 10.1038/ng.291.
Article
PubMed Central
CAS
PubMed
Google Scholar
Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, Pramstaller PP, Penninx BW, Janssens AC, Wilson JF, Spector T, et al: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet. 2009, 41 (1): 47-55. 10.1038/ng.269.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ridker PM, Pare G, Parker AN, Zee RY, Miletich JP, Chasman DI: Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women’s Genome Health Study. Circ Cardiovasc Genet. 2009, 2 (1): 26-33. 10.1161/CIRCGENETICS.108.817304.
Article
PubMed Central
CAS
PubMed
Google Scholar
Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, et al: Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010, 466 (7307): 707-713. 10.1038/nature09270.
Article
PubMed Central
CAS
PubMed
Google Scholar
Heid IM, Vollmert C, Kronenberg F, Huth C, Ankerst DP, Luchner A, Hinney A, Bronner G, Wichmann HE, Illig T, et al: Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study. Obesity (Silver Spring). 2008, 16 (2): 369-376. 10.1038/oby.2007.21.
Article
CAS
Google Scholar
Butler AA, Cone RD: The melanocortin receptors: lessons from knockout models. Neuropeptides. 2002, 36 (2–3): 77-84.
Article
CAS
PubMed
Google Scholar
Chambers J, Elliott P, Zabaneh D, Zhang W, Li Y, Froguel P, Balding D, Scott J, Kooner JS: Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet. 2008, 40 (6): 716-718. 10.1038/ng.156.
Article
CAS
PubMed
Google Scholar
Freathy RM, Timpson NJ, Lawlor DA, Pouta A, Ben-Shlomo Y, Ruokonen A, Ebrahim S, Shields B, Zeggini E, Weedon MN, et al: Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes. 2008, 57 (5): 1419-1426. 10.2337/db07-1466.
Article
PubMed Central
CAS
PubMed
Google Scholar
Borai A, Livingstone C, Abdelaal F, Bawazeer A, Keti V, Ferns G: The relationship between glycosylated haemoglobin (HbA1c) and measures of insulin resistance across a range of glucose tolerance. Scand J Clin Lab Invest. 2011, 71 (2): 168-172.
CAS
PubMed
Google Scholar
Abe H, Yamada N, Kamata K, Kuwaki T, Shimada M, Osuga J, Shionoiri F, Yahagi N, Kadowaki T, Tamemoto H, et al: Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1. J Clin Invest. 1998, 101 (8): 1784-1788. 10.1172/JCI1594.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kilpelainen TO, Zillikens MC, Stancakova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L, et al: Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet. 2011, 43 (8): 753-760. 710.1038/ng.1866.
Article
PubMed Central
CAS
PubMed
Google Scholar
Vassy JL, Shrader P, Yang Q, Liu T, Yesupriya A, Chang MH, Dowling NF, Ned RM, Dupuis J, Florez JC, et al: Genetic associations with metabolic syndrome and its quantitative traits by race/ethnicity in the United States. Metab Syndr Relat Disord. 2011, 9 (6): 475-482. 10.1089/met.2011.0021.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sjogren M, Lyssenko V, Jonsson A, Berglund G, Nilsson P, Groop L, Orho-Melander M: The search for putative unifying genetic factors for components of the metabolic syndrome. Diabetologia. 2008, 51 (12): 2242-2251. 10.1007/s00125-008-1151-4.
Article
CAS
PubMed
Google Scholar
Tonjes A, Scholz M, Loeffler M, Stumvoll M: Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals. Diabetes Care. 2006, 29 (11): 2489-2497. 10.2337/dc06-0513.
Article
PubMed
Google Scholar
Passaro A, Dalla Nora E, Marcello C, Di Vece F, Morieri ML, Sanz JM, Bosi C, Fellin R, Zuliani G: PPARgamma Pro12Ala and ACE ID polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome. Cardiovasc Diabetol. 2011, 10: 112-10.1186/1475-2840-10-112.
Article
PubMed Central
CAS
PubMed
Google Scholar
Chasman DI, Pare G, Mora S, Hopewell JC, Peloso G, Clarke R, Cupples LA, Hamsten A, Kathiresan S, Malarstig A, et al: Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet. 2009, 5 (11): e1000730-10.1371/journal.pgen.1000730.
Article
PubMed Central
PubMed
Google Scholar
Timpson NJ, Lawlor DA, Harbord RM, Gaunt TR, Day IN, Palmer LJ, Hattersley AT, Ebrahim S, Lowe GD, Rumley A, et al: C-reactive protein and its role in metabolic syndrome: mendelian randomisation study. Lancet. 2005, 366 (9501): 1954-1959. 10.1016/S0140-6736(05)67786-0.
Article
CAS
PubMed
Google Scholar
Rafiq S, Melzer D, Weedon MN, Lango H, Saxena R, Scott LJ, Palmer CN, Morris AD, McCarthy MI, Ferrucci L, et al: Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes. Diabetologia. 2008, 51 (12): 2205-2213. 10.1007/s00125-008-1160-3.
Article
PubMed Central
CAS
PubMed
Google Scholar
Davey Smith G, Ebrahim S: ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?. Int J Epidemiol. 2003, 32 (1): 1-22. 10.1093/ije/dyg070.
Article
Google Scholar
Yoshiuchi I: Evidence of selection at insulin receptor substrate-1 gene loci. Acta Diabetol. 2012, 15: 15.
Google Scholar
Heard-Costa N, Zillikens MC, Monda KL, Johansson A, Harris TB, Fu M, Haritunians T, Feitosa MF, Aspelund T, Eiriksdottir G, et al: NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet. 2009, 5 (6): e1000539-10.1371/journal.pgen.1000539.
Article
PubMed Central
PubMed
Google Scholar
Dehghan A, Dupuis J, Barbalic M, Bis JC, Eiriksdottir G, Lu C, Pellikka N, Wallaschofski H, Kettunen J, Henneman P, et al: Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation. 2011, 123 (7): 731-738. 10.1161/CIRCULATIONAHA.110.948570.
Article
PubMed Central
CAS
PubMed
Google Scholar
Jee SH, Sull JW, Lee JE, Shin C, Park J, Kimm H, Cho EY, Shin ES, Yun JE, Park JW, et al: Adiponectin concentrations: a genome-wide association study. Am J Hum Genet. 2010, 87 (4): 545-552. 10.1016/j.ajhg.2010.09.004.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kooner JS, Chambers JC, Aguilar-Salinas CA, Hinds DA, Hyde CL, Warnes GR, Gomez Perez FJ, Frazer KA, Elliott P, Scott J, et al: Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nat Genet. 2008, 40 (2): 149-151. 10.1038/ng.2007.61.
Article
CAS
PubMed
Google Scholar
Pollin TI, Damcott CM, Shen H, Ott SH, Shelton J, Horenstein RB, Post W, McLenithan JC, Bielak LF, Peyser PA, et al: A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection. Science. 2008, 322 (5908): 1702-1705. 10.1126/science.1161524.
Article
PubMed Central
CAS
PubMed
Google Scholar