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Table 4 Individual SNPs associated with waist circumference or insulin resistance in GWAS in relation to MetS and MetS-score

From: Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study

 

MetS

MetS-score

n

1886

1886

WC

  

FTO rs1421085

1.02(0.93; 1.12)

0.05(−0.03; 0.14)

MC4Rrs17782313 1

1.16(1.02; 1.32)

0.10(−0.05; 0.24)

IR

  

PPARG rs1801282

1.04(0.91; 1.19)

0.10(−0.02; 023)

IRS1 rs2943634

0.88(0.79; 0.97)

−0.14(−0.23;-0.06)

GCKR rs780094

0.99(0.89; 1.09)

0.05(−0.04; 0.13)

IGF1 rs35767

1.03(0.91; 1.16)

0.03(−0.08; 0.14)

GCK rs1799884

1.07(0.95; 1.20)

0.08(−0.03; 0.22)

  1. Data are presented as PR per minor allele for MetS and as minor allele change for MetS Score; Mets Metabolic syndrome, WC waist circumference, IR insulin resistance.
  2. All analyses are adjusted for age, sex and cohort.
  3. 1Data available in 853 women.