Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study

Povel, Cécile M; Boer, Jolanda MA; Onland-Moret, N Charlotte; Dollé, Martijn ET; Feskens, Edith JM; van der Schouw, Yvonne T

doi:10.1186/1475-2840-11-133

Cardiovascular Diabetology

Table 1 SNPs included in the analyses of random sample of EPIC-NL (n=1886)

From: Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study

Gene	SNP (literature)	SNP (dataset)	MAF (dataset)	ref	r²SNPs
Insulin resistance
PPARG	rs1801282	rs1801282	G: 0.13	[14]	-
IRS1	rs2943634	rs2943634	A: 0.35	[15]	-
GCKR	rs780094	rs780094	T: 0.37	[14]	-
IGF1	rs35767	rs35767	A: 0.16	[14]	-
GCK	rs4607517	rs1799884	T: 0.18	[14]	1
Abdominal obesity
FTO	rs1421085	rs1421085	C: 0.40	[16]	-
MC4R ¹	rs17782313	rs17782313	C: 0.25	[16]	-
Inflammation
IL6R	rs4537545	rs4537545	T: 0.39	[17]	-
LEPR	rs6700896	rs1805096	A: 0.38	[17]	0.89
CRP	rs7553007	rs1341665	A: 0.32	[17]	1
ADIPOQ	rs1648707	rs182052	A: 0.34	[18]	1
IL18	rs1834481	rs5744256	G: 0.26	[19]	1
GCKR	rs780094	rs780094	T: 0.37	[20]	-
Triglycerides
AFF1	rs442177	rs3775214	G: 0.43	[21]	0.96
APOB	rs673548	rs673548	A: 0.22	[22]	-
APOB	rs693	rs693	G: 0.50	[23]	-
APOA5-A4-C3-A1	rs12286037	rs12286037	T: 0.08	[24]	-
APOA5	rs6589566	rs2075290	C: 0.06	[25]	1
FADS1	rs174548	rs174548	G: 0.29	[21]
FADS1-2-3	rs174547	rs174577	A: 0.35	[26]	1
GALNT2	rs4846914	rs4846914	G: 0.41	[23]	-
LPL	rs328	rs328	G: 0.10	[23]	-
MLXIPL	rs17145738	rs17145750	T: 0.16	[24]	0.86
PLTP	rs7679	rs6073952	A: 0.20	[26]	0.82
TRIB1	rs2954029	rs2954029	T: 0.47	[26]	-
CLIP2	rs16996148	rs16996148	T: 0.10	[24]	-
GCKR	rs780094	rs780094	T: 0.37	[27]	-
ANGPTL3-DOCK7	rs1748195	rs1748197	A: 0.35	[24]	1
ANGPTL3-DOCK7	rs12130333	rs12130333	T: 0.24	[23]	-
HDL cholesterol
ABCA1	rs1883025	rs1883025	T: 0.24	[26]	-
ABCA1	rs3890182	rs3890182	A: 0.10	[21]	-
APOB	rs11902417	rs11902417	A: 0.24	[21]	-
CETP	rs1800775	rs1800775	A: 0.46	[28]	-
CETP	rs3764261	rs3764261	A: 0.31	[29]	-
FADS1	rs174548	rs174548	G: 0.29	[21]	-
FADS1-2-3	rs174547	rs174577	A: 0.35	[26]	-
GALNT2	rs4846914	rs4846914	G: 0.41	[23]	-
LCAT	rs255052	rs255052	A: 0.17	[24]	-
LCAT	rs12449157	rs1109166	C: 0.18	[21]	0.94
LIPC	rs1800588	rs1800588	T: 0.22	[23]	-
LIPG	rs2156552	rs2156552	A: 0.16	[21]	-
LPL	rs328	rs328	G: 0.10	[23]	-
PLTP	rs7679	rs6073952	A: 0.20	[26]	0.82
MMAB MVK	rs2338104	rs10774708	A: 0.47	[26]	1
HNF4A	rs1800961	rs1800961	T: 0.04	[26]	-

¹Data available in 853 women.

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ISSN: 1475-2840

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