Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study

Table 3 P-values for Goeman’s global test, testing the statistical significance of associations of waist circumference and insulin resistance SNPs with metabolic syndrome and related features

Group of SNPs	MetS	MetS-score	WC (cm)	HbA1C (%)	Log (TG) (mmol/L)	HDL (mmol/L)	SBP (mm HG)	DBP (mm HG)	Log (CRP) (mmol/L)
n	1886	1886	1886	1864 ¹	1886	1886	1684 ³	1684 ³	1683 ²
WC ⁴	P=0.03	P=0.08	P=0.01	P=0.73	P=0.81	P=0.36	P=0.29	P=0.11	P=0.22
Adj WC	P=0.16	P=0.80	-	P=0.47	P=0.55	P=0.09	P=0.36	P=0.34	P=0.68
IR	P=0.06	P=0.003	P=0.45	P=0.04	P=0.0003	P=0.0005	P=0.07	P=0.16	P=0.16
Adj HbA1C	P=0.12	P=0.01	P=0.70	-	P=0.0005	P=0.0008	P=0.10	P=0.22	P=0.17

All analyses are adjusted for age, sex and cohort; Mets Metabolic syndrome, WC waist circumference, TG triglycerides, HDL HDL-cholesterol, HbA1C haemoglobin A1c, SBP systolic blood pressure, DBP diastolic blood pressure, Adj, adjusted, IR insulin resistance.
¹Subjects which are using glucose lowering medication are excluded.
²Subjects with CRP > 10 mmol/L are excluded.
³Subjects with blood pressure lowering medication are excluded.
⁴Data available in 853 women.

ISSN: 1475-2840