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  1. In a previous study, we demonstrated that the thickness of epicardial adipose tissue (EAT), measured by echocardiography, was increased in patients with metabolic syndrome (MS) and coronary artery disease (CAD...

    Authors: Jin-Sun Park, Sung-Gyun Ahn, Jung-Won Hwang, Hong-Seok Lim, Byoung-Joo Choi, So-Yeon Choi, Myeong-Ho Yoon, Gyo-Seung Hwang, Seung-Jea Tahk and Joon-Han Shin

    Citation: Cardiovascular Diabetology 2010 9:29

    Content type: Original investigation

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  2. The purpose of this study was to test the hypothesis that sidestream tobacco smoke extracts would inhibit the culture of endothelial cells and enhance platelet aggregation under diabetic vascular conditions. S...

    Authors: David A Rubenstein, Blake E Morton and Wei Yin

    Citation: Cardiovascular Diabetology 2010 9:28

    Content type: Original investigation

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  3. Insulin resistance (IR) and related metabolic disturbances are characterized by low levels of adiponectin. High molecular weight adiponectin (HMWA) is considered the active form of adiponectin and a better mar...

    Authors: Paloma Almeda-Valdes, Daniel Cuevas-Ramos, Roopa Mehta, Francisco J Gomez-Perez, Ivette Cruz-Bautista, Olimpia Arellano-Campos, Mariana Navarrete-Lopez and Carlos A Aguilar-Salinas

    Citation: Cardiovascular Diabetology 2010 9:26

    Content type: Original investigation

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  4. In patients with myocardial infarction or heart failure, right ventricular (RV) dysfunction is associated with death, shock and arrhythmias. In patients with type 2 diabetes mellitus, structural and functional...

    Authors: Charissa E van den Brom, Joanna WAM Bosmans, Ronald Vlasblom, Louis M Handoko, Marc C Huisman, Mark Lubberink, Carla FM Molthoff, Adriaan A Lammertsma, Margriet D Ouwens, Michaela Diamant and Christa Boer

    Citation: Cardiovascular Diabetology 2010 9:25

    Content type: Original investigation

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  5. Diabetes is a major challenge for the health care system and especially for the primary care provider. The Chronic Care Model represents an evidence-based framework for the care for chronically ill. An increas...

    Authors: Anja Frei, Corinne Chmiel, Hansueli Schläpfer, Beatrice Birnbaum, Ulrike Held, Johann Steurer and Thomas Rosemann

    Citation: Cardiovascular Diabetology 2010 9:23

    Content type: Study protocol

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  6. Studies of beta blockade in patients with type 2 diabetes have shown inferiority of metoprolol treatment compared to carvedilol on indices of insulin resistance. The aim of this study was to examine the effect...

    Authors: Britt Kveiborg, Thomas S Hermann, Atheline Major-Pedersen, Buris Christiansen, Christian Rask-Madsen, Jakob Raunsø, Lars Køber, Christian Torp-Pedersen and Helena Dominguez

    Citation: Cardiovascular Diabetology 2010 9:21

    Content type: Original investigation

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  7. The primary goal of therapy in patients with hypercholesterolemia and coronary heart disease (CHD) is reducing low-density lipoprotein cholesterol (LDL-C). This was a multicenter, randomized, double-blind, dou...

    Authors: Gianluca Bardini, Carlo B Giorda, Antonio E Pontiroli, Cristina Le Grazie and Carlo M Rotella

    Citation: Cardiovascular Diabetology 2010 9:20

    Content type: Original investigation

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  8. Endothelial dysfunction precedes atherogenesis and clinical complications in type 2 diabetes. The vascular dysfunction in Zucker diabetic fatty (ZDF) rats was evaluated at different ages along with the effect ...

    Authors: Xiao Lu, Xiaomei Guo, Sotirios K Karathanasis, Karen M Zimmerman, Jude E Onyia, Richard G Peterson and Ghassan S Kassab

    Citation: Cardiovascular Diabetology 2010 9:19

    Content type: Original investigation

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  9. To study the relationship between the intima-media thickness (IMT) of the carotid artery and the stage of chronic kidney disease (CKD) based on the estimated glomerular filtration rate (eGFR) and diabetic neph...

    Authors: Hiroyuki Ito, Yuko Komatsu, Mizuo Mifune, Shinichi Antoku, Hidenori Ishida, Yuichiro Takeuchi and Michiko Togane

    Citation: Cardiovascular Diabetology 2010 9:18

    Content type: Original investigation

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  10. Glucagon-like peptide-1 (GLP-1) is an incretin hormone that has a wide range of effects on glucose metabolism and cardiovascular function (e.g., improving insulin sensitivity, reduction in appetite, modulation...

    Authors: Minako Yamaoka-Tojo, Taiki Tojo, Naonobu Takahira, Atsuhiko Matsunaga, Naoyoshi Aoyama, Takashi Masuda and Tohru Izumi

    Citation: Cardiovascular Diabetology 2010 9:17

    Content type: Original investigation

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  11. To evaluate glycemic variability associated with two different premixed insulin analogue formulations when used in a twice-daily regimen.

    Authors: Rimei Nishimura, Daisuke Tsujino, Kentaro Taki, Aya Morimoto and Naoko Tajima

    Citation: Cardiovascular Diabetology 2010 9:16

    Content type: Original investigation

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  12. Although there is a growing body of evidence showing that patients with type 2 diabetes mellitus (T2DM) have poor glycemic control in general, it is not clear whether T2DM patients with pre-existing cardiovasc...

    Authors: Alex Z Fu, Ying Qiu, Larry Radican, Donald D Yin and Panagiotis Mavros

    Citation: Cardiovascular Diabetology 2010 9:15

    Content type: Original investigation

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  13. Many studies on diabetes have demonstrated that an intensive control of glycaemia and the main associated risk factors (hypertension, dislipidaemia, obesity and smoking) reduce cardiovascular morbi-mortality. ...

    Authors: Lucas Mengual, Pilar Roura, Marta Serra, Montserrat Montasell, Gemma Prieto and Sandra Bonet

    Citation: Cardiovascular Diabetology 2010 9:14

    Content type: Original investigation

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  14. Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor, which regulates gene expression of the key proteins involved in lipid metabolism, vascular inflammation, and pro...

    Authors: Jing Wan, Shixi Xiong, Shengping Chao, Jianming Xiao, Yexin Ma, Jinghua Wang and Sabita Roy

    Citation: Cardiovascular Diabetology 2010 9:13

    Content type: Original investigation

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  15. Postprandial hyperglycemia is believed to affect vascular endothelial function. The aim of our study was to compare the effects of acarbose and nateglinide on postprandial endothelial dysfunction.

    Authors: Toru Kato, Teruo Inoue and Koichi Node

    Citation: Cardiovascular Diabetology 2010 9:12

    Content type: Original investigation

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  16. The metabolic syndrome is thought to be associated with a chronic low-grade inflammation, and a growing body of evidence suggests that interleukin-18 (IL-18) might be closely related to the metabolic syndrome ...

    Authors: Marius Trøseid, Ingebjørg Seljeflot and Harald Arnesen

    Citation: Cardiovascular Diabetology 2010 9:11

    Content type: Review

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  17. Adiponectin is an adipose tissue secreted protein known for its insulin sensitising and anti-atherogenic actions. To this date two adiponectin receptors have been discovered, adiponectin receptor 1 (ADIPOR1) a...

    Authors: Iosif Halvatsiotis, Panayoula C Tsiotra, Ignatios Ikonomidis, Anastasios Kollias, Panagiota Mitrou, Eirini Maratou, Eleni Boutati, John Lekakis, George Dimitriadis, Theofanis Economopoulos, Dimitrios T Kremastinos and Sotirios A Raptis

    Citation: Cardiovascular Diabetology 2010 9:10

    Content type: Original investigation

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  18. CVD in obesity and T2DM are associated with endothelial activation, elevated plasma vascular inflammation markers and a prothrombotic state. We examined the contribution of FFA to these abnormalities following...

    Authors: Manoj Mathew, Eric Tay and Kenneth Cusi

    Citation: Cardiovascular Diabetology 2010 9:9

    Content type: Original investigation

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  19. Diminished calcium (Ca2+) transients in response to physiological agonists have been reported in vascular smooth muscle cells (VSMCs) from diabetic animals. However, the mechanism responsible was unclear.

    Authors: Yvonne M Searls, Rajprasad Loganathan, Irina V Smirnova and Lisa Stehno-Bittel

    Citation: Cardiovascular Diabetology 2010 9:8

    Content type: Original investigation

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  20. This cross-sectional study sought to determine the prevalence of cardiometabolic risk factor clusters (CMRFCs) and their effect on BP control among hypertensive patients from 28 US physician practices.

    Authors: Daniel A Belletti, Christopher Zacker and Jenifer Wogen

    Citation: Cardiovascular Diabetology 2010 9:7

    Content type: Original investigation

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  21. Cardiovascular effects of glucose-lowering agents are of increasing interest. Our aim was to assess the effects of the glucagon-like peptide-1 receptor agonist exenatide on heart rate (HR) and blood pressure (...

    Authors: Anne Gill, Byron J Hoogwerf, Jude Burger, Simon Bruce, Leigh MacConell, Ping Yan, Daniel Braun, Joseph Giaconia and James Malone

    Citation: Cardiovascular Diabetology 2010 9:6

    Content type: Original investigation

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  22. Diabetes is associated with changes in myocardial stress-response pathways and is recognized as an independent risk factor for cardiac remodeling. Using spontaneously diabetic Goto Kakizaki rats as a model of ...

    Authors: Erik Vahtola, Marjut Louhelainen, Hanna Forstén, Saara Merasto, Johanna Raivio, Petri Kaheinen, Ville Kytö, Ilkka Tikkanen, Jouko Levijoki and Eero Mervaala

    Citation: Cardiovascular Diabetology 2010 9:5

    Content type: Original investigation

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  23. The aim of this study was to determine whether South Asian patients with diabetes have a worse prognosis following hospitalization for acute myocardial infarction (AMI) compared with their White counterparts. ...

    Authors: Aman PK Nijjar, Hong Wang, Kaberi Dasgupta, Doreen M Rabi, Hude Quan and Nadia A Khan

    Citation: Cardiovascular Diabetology 2010 9:4

    Content type: Original investigation

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  24. Patients with diabetes mellitus (DM) have high risk of heart failure. Whether some of the risk is directly linked to metabolic derangements in the myocardium or whether the risk is primarily caused by coronary...

    Authors: Charlotte Andersson, Gunnar H Gislason, Peter Weeke, Søren Hoffmann, Peter R Hansen, Christian Torp-Pedersen and Peter Søgaard

    Citation: Cardiovascular Diabetology 2010 9:3

    Content type: Original investigation

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  25. The aims of this study were to estimate the prevalence of left ventricular systolic (LVSD) and diastolic (LVDD) dysfunction, and to test if BNP and urinary albumin excretion rate (AER) are related to LVSD, LVD...

    Authors: Martin Magnusson, Stefan Jovinge, Kambiz Shahgaldi, Bo Israelsson, Leif Groop and Olle Melander

    Citation: Cardiovascular Diabetology 2010 9:2

    Content type: Original investigation

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  26. The long-term prognosis of diabetic patients with acute myocardial infarction (AMI) treated by acute revascularization is uncertain, and the optimal pharmacotherapy for such cases has not been fully evaluated.

    Authors: Ayako Takara, Hiroshi Ogawa, Yasuhiro Endoh, Fumiaki Mori, Jun-ichi Yamaguchi, Atsushi Takagi, Ryo Koyanagi, Tsuyoshi Shiga, Hiroshi Kasanuki and Nobuhisa Hagiwara

    Citation: Cardiovascular Diabetology 2010 9:1

    Content type: Original investigation

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  27. Dysfunctionally uncoupled endothelial nitric oxide synthase (eNOS) is involved in producing reactive oxygen species (ROS) in the diabetic endothelium. The present study investigated whether anti-diabetes drug ...

    Authors: Jeong-Ho Oak, Ji-Youn Youn and Hua Cai

    Citation: Cardiovascular Diabetology 2009 8:65

    Content type: Original investigation

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  28. Vascular smooth muscular cells (VSMC) express lipogenic genes. Therefore in situ lipogenesis could provide fatty acids for triglycerides synthesis and cholesterol esterification and contribute to lipid accumulati...

    Authors: Nadjiba Hamlat, Fabien Forcheron, Samia Negazzi, Peggy del Carmine, Patrick Feugier, Giampiero Bricca, Souhila Aouichat-Bouguerra and Michel Beylot

    Citation: Cardiovascular Diabetology 2009 8:64

    Content type: Original investigation

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  29. Hepatocyte nuclear factor 4α (HNF4α) is a nuclear receptor involved in glucose homeostasis and is required for normal β cell function. Mutations in the HNF4α gene are associated with maturity onset diabetes of...

    Authors: Seyed Morteza Taghavi, Seyedeh Seddigheh Fatemi, Houshang Rafatpanah, Rashin Ganjali, Jalil Tavakolafshari and Narges Valizadeh

    Citation: Cardiovascular Diabetology 2009 8:63

    Content type: Original investigation

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  30. Patients with obesity, diabetes, and chronic kidney disease (CKD) are generally physically inactive, have a high mortality rate, and may benefit from an exercise program.

    Authors: David J Leehey, Irfan Moinuddin, Joseph P Bast, Shahzad Qureshi, Christine S Jelinek, Cheryl Cooper, Lonnie C Edwards, Bridget M Smith and Eileen G Collins

    Citation: Cardiovascular Diabetology 2009 8:62

    Content type: Original investigation

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  31. Resistin, secreted from adipocytes, causes insulin resistance in mice. The relationship between resistin and coronary artery disease is highly controversial, and the information regarding resistin and ischemic...

    Authors: Haruhiko Osawa, Yasufumi Doi, Hideichi Makino, Toshiharu Ninomiya, Koji Yonemoto, Ryoichi Kawamura, Jun Hata, Yumihiro Tanizaki, Mitsuo Iida and Yutaka Kiyohara

    Citation: Cardiovascular Diabetology 2009 8:60

    Content type: Original investigation

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  32. A large number of people throughout the world have diabetes and the prevalence is increasing. Persons with diabetes have a twice higher risk of cardiovascular disease than those without diabetes. There is a la...

    Authors: Marina Taloyan, Alexandre Wajngot, Sven-Erik Johansson, Jonas Tovi and Jan Sundquist

    Citation: Cardiovascular Diabetology 2009 8:59

    Content type: Original investigation

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  33. Diabetes mellitus (DM) has reached epidemic proportions and is an important risk factor for heart failure (HF). Left ventricular diastolic dysfunction (LVDD) is recognized as the earliest manifestation of DM-i...

    Authors: Wilfried Dinh, Reiner Füth, Werner Nickl, Thomas Krahn, Peter Ellinghaus, Thomas Scheffold, Lars Bansemir, Alexander Bufe, Michael Coll Barroso and Mark Lankisch

    Citation: Cardiovascular Diabetology 2009 8:58

    Content type: Original investigation

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  34. The risk-benefit ratio of aspirin therapy in prevention of cardiovascular disease (CVD) remains contentious, especially in type 2 diabetes. This study examined the benefit and harm of low-dose aspirin (daily d...

    Authors: Wilson Y Leung, Wing-yee So, Derek Stewart, Augustine Lui, Peter C Tong, Gary T Ko, Alice P Kong, Ronald C Ma, Francis K Chan, Xilin Yang, Sau-chu Chiang and Juliana C Chan

    Citation: Cardiovascular Diabetology 2009 8:57

    Content type: Original investigation

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  35. The function of endothelial progenitor cells (EPCs), which are key cells in vascular repair, is impaired in diabetes mellitus. Nitric oxide (NO) and reactive oxygen species can regulate EPC functions. EPCs tol...

    Authors: Saher Hamed, Benjamin Brenner, Anat Aharon, Deeb Daoud and Ariel Roguin

    Citation: Cardiovascular Diabetology 2009 8:56

    Content type: Original investigation

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  36. Increased resting heart rate (RHR) may be associated with increased cardiovascular morbidity. Our aim was to explore the possibility that increased RHR is associated with the prevalence of the metabolic syndro...

    Authors: Ori Rogowski, Arie Steinvil, Shlomo Berliner, Michael Cohen, Nili Saar, Orit Kliuk Ben-Bassat and Itzhak Shapira

    Citation: Cardiovascular Diabetology 2009 8:55

    Content type: Original investigation

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  37. Cardiovascular disease is the main cause of premature death in patients with type 1 diabetes. Patients with diabetic kidney disease have an increased risk of heart attack or stroke. Accurate knowledge of the c...

    Authors: Ville-Petteri Mäkinen, Carol Forsblom, Lena M Thorn, Johan Wadén, Kimmo Kaski, Mika Ala-Korpela and Per-Henrik Groop

    Citation: Cardiovascular Diabetology 2009 8:54

    Content type: Original investigation

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  38. Patients with type 2 diabetes are at increased risk of cardiovascular events, and there is an associated economic burden attached to this risk. We conducted a retrospective claims database analysis to evaluate...

    Authors: Robert J Straka, Larry Z Liu, Prafulla S Girase, Allyson DeLorenzo and Richard H Chapman

    Citation: Cardiovascular Diabetology 2009 8:53

    Content type: Original investigation

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  39. Metabolic syndrome increases cardiovascular risk. Limited information on its prevalence in Latin America is available. The Cardiovascular Risk Factor Multiple Evaluation in Latin America (CARMELA) study includ...

    Authors: Jorge Escobedo, Herman Schargrodsky, Beatriz Champagne, Honorio Silva, Carlos P Boissonnet, Raul Vinueza, Marta Torres, Rafael Hernandez and Elinor Wilson

    Citation: Cardiovascular Diabetology 2009 8:52

    Content type: Original investigation

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  40. The GOOD (Global Cardiometabolic Risk Profile in Patients with Hypertension Disease) survey showed that blood pressure control was significantly worse in hypertensive patients with metabolic syndrome and/or di...

    Authors: Walter Zidek, Lisa Naditch-Brûlé, Stefano Perlini, Csaba Farsang and Sverre E Kjeldsen

    Citation: Cardiovascular Diabetology 2009 8:51

    Content type: Original investigation

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  41. Myocardial infarction results as a consequence of atherosclerotic plaque rupture, with plaque stability largely depending on the lesion forming extracellular matrix components. Lipid enriched non-calcified les...

    Authors: Michael Lehrke, Martin Greif, Uli C Broedl, Corinna Lebherz, Rüdiger P Laubender, Alexander Becker, Franz von Ziegler, Janine Tittus, Maximilian Reiser, Christoph Becker, Burkhard Göke, Gerhard Steinbeck, Alexander W Leber and Klaus G Parhofer

    Citation: Cardiovascular Diabetology 2009 8:50

    Content type: Original investigation

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  42. Type 2 diabetes mellitus (T2DM) is commonly associated with both microvascular and macrovascular complications and a strong correlation exists between glycaemic control and the incidence and progression of vas...

    Authors: Federico Biscetti, Giuseppe Straface, Vincenzo Arena, Egidio Stigliano, Giovanni Pecorini, Paola Rizzo, Giulia De Angelis, Luigi Iuliano, Giovanni Ghirlanda and Andrea Flex

    Citation: Cardiovascular Diabetology 2009 8:49

    Content type: Original investigation

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  43. Thrombosis is regarded to be a key factor in the development of acute coronary syndromes in patients with coronary artery disease (CAD). We hypothesize, that hemostatic and rheological risk factors may be of m...

    Authors: Thomas W Jax, Ansgar J Peters, Gunnar Plehn and Frank-Chris Schoebel

    Citation: Cardiovascular Diabetology 2009 8:48

    Content type: Original investigation

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  44. Endothelial progenitor cells play an important role in vascular wall repair. Patients with type 1 diabetes have reduced levels of endothelial progenitor cells of which their functional capacity is impaired. Re...

    Authors: Olivia van Oostrom, Dominique PV de Kleijn, Joost O Fledderus, Mario Pescatori, Andrew Stubbs, Attie Tuinenburg, Sai Kiang Lim and Marianne C Verhaar

    Citation: Cardiovascular Diabetology 2009 8:47

    Content type: Original investigation

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  45. Heparan sulfate proteoglycans (HSPGs) contain glycosaminoglycan (GAG) chains made primarily of heparan sulfate (HS). Hyperglycemia in diabetes leads to endothelial injury and nephropathy, retinopathy and ather...

    Authors: Juying Han, Fuming Zhang, Jin Xie, Robert J Linhardt and Linda M Hiebert

    Citation: Cardiovascular Diabetology 2009 8:46

    Content type: Original investigation

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  46. Nε-Carboxymethyllysine (CML) is the major non-cross linking advanced glycation end product (AGE). CML is elevated in diabetic patients and apparent in atherosclerotic lesions. AGEs are associated with hypertensi....

    Authors: Marcus Baumann, Tom Richart, Daniel Sollinger, Jaroslav Pelisek, Marcel Roos, Tatiana Kouznetsova, Hans-Henning Eckstein, Uwe Heemann and Jan A Staessen

    Citation: Cardiovascular Diabetology 2009 8:45

    Content type: Original investigation

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