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  1. Studies assessing the efficacy of pioglitazone solely for primary stroke prevention in Asian patients with type 2 diabetes mellitus (DM) and present multiple cardiovascular (CV) risk factors are rare. Thus, we...

    Authors: Yi-Chih Hung, Lu-Ting Chiu, Hung-Yu Huang and Da-Tian Bau

    Citation: Cardiovascular Diabetology 2020 19:94

    Content type: Original investigation

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  2. The potential for PPAR agonists to positively affect risk of cardiovascular disease in patients with type 2 diabetes (T2DM) is of persistent attention. The PRESS XII study primarily aimed to evaluate the effic...

    Authors: Manjunath Krishnappa, Kishor Patil, Krupi Parmar, Purav Trivedi, Nirali Mody, Chintan Shah, Khushboo Faldu, Sanjay Maroo and Deven Parmar

    Citation: Cardiovascular Diabetology 2020 19:93

    Content type: Original investigation

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  3. Accumulation of advanced glycation end products (AGEs) leads to chronic glycation of proteins and tissue damage, particularly in patients with diabetes mellitus (DM). We aimed to evaluate whether increased acc...

    Authors: Magdalena Kopytek, Michał Ząbczyk, Piotr Mazur, Anetta Undas and Joanna Natorska

    Citation: Cardiovascular Diabetology 2020 19:92

    Content type: Original investigation

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  4. A sodium-glucose co-transporter 2 (SGLT-2) inhibitor had favorable impact on the attenuation of hyperglycemia together with the severity of heart failure. However, the effects of acute dapagliflozin administra...

    Authors: Sarayut Lahnwong, Siripong Palee, Nattayaporn Apaijai, Sirawit Sriwichaiin, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Siriporn C. Chattipakorn and Nipon Chattipakorn

    Citation: Cardiovascular Diabetology 2020 19:91

    Content type: Original investigation

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  5. Exercise induced albuminuria (EiA) is elevated in patients with metabolic dysfunction and diabetes, and may serve as an early biomarker for endothelial dysfunction and “kidney reserve”. However, the change in ...

    Authors: Rafael Y. Brzezinski, Limor Friedensohn, Itzhak Shapira, David Zeltser, Ori Rogowski, Shlomo Berliner, Ayelet Grupper and Shani Shenhar-Tsarfaty

    Citation: Cardiovascular Diabetology 2020 19:90

    Content type: Original investigation

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  6. Fatty acid-binding protein 4 (FABP4) acts as a novel adipokine, and elevated FABP4 concentration is associated with obesity, insulin resistance and atherosclerosis. Dipeptidyl peptidase-4 (DPP-4) inhibitors, a...

    Authors: Masato Furuhashi, Ichiro Sakuma, Takeshi Morimoto, Yukimura Higashiura, Akiko Sakai, Megumi Matsumoto, Mio Sakuma, Michio Shimabukuro, Takashi Nomiyama, Osamu Arasaki, Koichi Node and Shinichiro Ueda

    Citation: Cardiovascular Diabetology 2020 19:89

    Content type: Original investigation

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  7. The role of right ventricular (RV) and atrial (RA) structure and function, in the increased heart failure risk in (pre)diabetes is incompletely understood. The purpose of this study is to investigate the assoc...

    Authors: Pauline B. C. Linssen, Marja G. J. Veugen, Ronald M. A. Henry, Carla J. H. van der Kallen, Abraham A. Kroon, Miranda T. Schram, Hans-Peter Brunner-La Rocca and Coen D. A. Stehouwer

    Citation: Cardiovascular Diabetology 2020 19:88

    Content type: Original investigation

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  8. Cardiovascular outcome trials of sodium-glucose co-transporter-2 inhibitors (SGLT2i CVOTs) found the agents to be associated with clinical benefits in terms of cardiovascular and renal outcomes. We performed a...

    Authors: Marco Castellana, Filippo Procino, Rodolfo Sardone, Pierpaolo Trimboli and Gianluigi Giannelli

    Citation: Cardiovascular Diabetology 2020 19:87

    Content type: Original investigation

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  9. Type 2 diabetes mellitus (DM) is a risk factor for cardiovascular diseases and is common among patients undergoing coronary artery bypass grafting (CABG) surgery. The main objective of our study was to investi...

    Authors: Eilon Ram, Leonid Sternik, Robert Klempfner, Zaza Iakobishvili, Enrique Z. Fisman, Alexander Tenenbaum, Elchanan Zuroff, Yael Peled and Ehud Raanani

    Citation: Cardiovascular Diabetology 2020 19:86

    Content type: Original investigation

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  10. Type 2 diabetes (T2D) is associated with renal impairment and vascular endothelial dysfunction. Therefore, this pathological connection is an important therapeutic target. Recent cardiovascular and renal outco...

    Authors: Atsushi Tanaka, Michio Shimabukuro, Yosuke Okada, Kazuhiro Sugimoto, Akira Kurozumi, Keiichi Torimoto, Hiroyuki Hirai and Koichi Node

    Citation: Cardiovascular Diabetology 2020 19:85

    Content type: Study protocol

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  11. Left ventricular (LV) longitudinal dysfunction has been identified in type 2 diabetes mellitus (T2DM) patients with preserved LV ejection fraction (LVEF). However, the impact of T2DM on LV longitudinal functio...

    Authors: Hidekazu Tanaka, Kazuhiro Tatsumi, Hiroki Matsuzoe, Kensuke Matsumoto and Ken-ichi Hirata

    Citation: Cardiovascular Diabetology 2020 19:84

    Content type: Original investigation

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  12. Current evidence about the cardiovascular safety of glucagon-like peptide-1 receptor agonist (GLP-1ra) possesses limited generalizability to real-world patients with type 2 diabetes (T2D) in usual practice. Th...

    Authors: Chun-Ting Yang, Chen-Yi Yang, Huang-Tz Ou and Shihchen Kuo

    Citation: Cardiovascular Diabetology 2020 19:83

    Content type: Original investigation

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  13. Reactive hyperemia-peripheral arterial tonometry (RH-PAT) is a noninvasive and simple test for evaluating the endothelial function. There has been sparse evidence on the usefulness of the RH-PAT index (RHI) in...

    Authors: Bo Kyung Koo, Woo-Young Chung and Min Kyong Moon

    Citation: Cardiovascular Diabetology 2020 19:82

    Content type: Original investigation

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  14. There is increasing concern regarding cardiovascular risk in individuals with non-alcoholic fatty liver disease. This study was conducted to evaluate whether hepatic steatosis with or without fibrosis is assoc...

    Authors: Hyeok-Hee Lee, Yongin Cho, Young Ju Choi, Byung Wook Huh, Byung-Wan Lee, Eun Seok Kang, Seok Won Park, Bong-Soo Cha, Eun Jig Lee, Yong-ho Lee and Kap Bum Huh

    Citation: Cardiovascular Diabetology 2020 19:81

    Content type: Original investigation

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  15. The triglyceride-glucose index (TyG index) has been regarded as a reliable alternative marker of insulin resistance and an independent predictor of cardiovascular outcomes. Whether the TyG index predicts adver...

    Authors: Le Wang, Hong-liang Cong, Jing-xia Zhang, Yue-cheng Hu, Ao Wei, Ying-yi Zhang, Hua Yang, Li-bin Ren, Wei Qi, Wen-yu Li, Rui Zhang and Jing-han Xu

    Citation: Cardiovascular Diabetology 2020 19:80

    Content type: Original investigation

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  16. Severe obesity among children and adolescents is a significant global public health concern. The prevalence has markedly increased over the last decades, becoming common in many countries. Overwhelming rates o...

    Authors: Cole D. Bendor, Aya Bardugo, Orit Pinhas-Hamiel, Arnon Afek and Gilad Twig

    Citation: Cardiovascular Diabetology 2020 19:79

    Content type: Review

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  17. Bodyweight variability is a risk factor for atrial fibrillation (AF). We aimed to examine the relationship between bodyweight variability and the risk of AF in patients with type 2 diabetes mellitus (DM), and ...

    Authors: Hyun-Jung Lee, Eue-Keun Choi, Kyung-Do Han, Da Hye Kim, Euijae Lee, So-Ryoung Lee, Seil Oh and Gregory Y. H. Lip

    Citation: Cardiovascular Diabetology 2020 19:78

    Content type: Original investigation

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  18. We aimed to investigate the hazard of hospitalization for heart failure (hHF) according to the transitions in metabolic health and obesity status.

    Authors: You-Bin Lee, Da Hye Kim, Seon Mee Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Kyungdo Han and Hye Jin Yoo

    Citation: Cardiovascular Diabetology 2020 19:77

    Content type: Original investigation

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  19. A possible association could exist between type 2 diabetes mellitus (T2DM) and Coronavirus-19 (Covid-19) infection. Indeed, patients with T2DM show high prevalence, severity of disease and mortality during Cov...

    Authors: Celestino Sardu, Giuseppe Gargiulo, Giovanni Esposito, Giuseppe Paolisso and Raffaele Marfella

    Citation: Cardiovascular Diabetology 2020 19:76

    Content type: Commentary

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  20. Although an increased arterial stiffness has been associated with traditional coronary risk factors, the risk factors and pathology of arterial stiffness remain unclear. In this study, we aimed to identify the...

    Authors: Naoto Katakami, Kazuo Omori, Naohiro Taya, Shoya Arakawa, Mitsuyoshi Takahara, Taka-aki Matsuoka, Hiroshi Tsugawa, Masahiro Furuno, Takeshi Bamba, Eiichiro Fukusaki and Iichiro Shimomura

    Citation: Cardiovascular Diabetology 2020 19:75

    Content type: Original investigation

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  21. Cardiovascular outcome trials in high-risk patients showed that some GLP-1 receptor agonists (GLP-1RA), but not dipeptidyl-peptidase-4 inhibitors (DPP-4i), can prevent cardiovascular events in type 2 diabetes ...

    Authors: Enrico Longato, Barbara Di Camillo, Giovanni Sparacino, Lara Tramontan, Angelo Avogaro and Gian Paolo Fadini

    Citation: Cardiovascular Diabetology 2020 19:74

    Content type: Original investigation

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  22. Clinical trials have shown the cardiovascular protective effect of sodium–glucose cotransporter-2 (SGLT2) inhibitors and reduced hospitalization for heart failure. However, no study has investigated the associ...

    Authors: Hung-Yi Chen, Jing-Yang Huang, Wun-Zhih Siao and Gwo-Ping Jong

    Citation: Cardiovascular Diabetology 2020 19:73

    Content type: Original investigation

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  23. Endothelial Progenitor cells (EPCs) has been shown to be dysfunctional in both type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) leading to poor regeneration of endothelium and renal perfusion. ...

    Authors: Hassan B. Awal, Seshagiri Rao Nandula, Cleyton C. Domingues, Fiona J. Dore, Nabanita Kundu, Beda Brichacek, Mona Fakhri, Adrian Elzarki, Neeki Ahmadi, Shauna Safai, Magan Fosso, Richard L. Amdur and Sabyasachi Sen

    Citation: Cardiovascular Diabetology 2020 19:72

    Content type: Original investigation

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  24. Postprandial hyperglycemia was reported to play a key role in established risk factors of coronary artery diseases (CAD) and cardiovascular events. Serum 1,5-anhydroglucitol (1,5-AG) levels are known to be a c...

    Authors: Gong Su, Ming-Xi Gao, Gen-Ling Shi, Xi-Xi Dai, Wei-Feng Yao, Tao Zhang and Shao-Wei Zhuang

    Citation: Cardiovascular Diabetology 2020 19:71

    Content type: Original investigation

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  25. Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that collectively cause an increased risk of type 2 diabetes mellitus (T2DM) and nonatherosclerotic cardiovascular disease. This study aimed to...

    Authors: Yue Gao, Yan Ren, Ying-kun Guo, Xi Liu, Lin-jun Xie, Li Jiang, Meng-ting Shen, Ming-yan Deng and Zhi-gang Yang

    Citation: Cardiovascular Diabetology 2020 19:70

    Content type: Original investigation

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  26. The effects of sodium-glucose cotransporter 2 inhibitor (SGLT2i) on cardiac function are not fully understood. We investigated the changes in cardiac function in diabetic patients according to the presence and...

    Authors: In-Chang Hwang, Goo-Yeong Cho, Yeonyee E. Yoon, Jin Joo Park, Jun-Bean Park, Seung-Pyo Lee, Hyung-Kwan Kim, Yong-Jin Kim and Dae-Won Sohn

    Citation: Cardiovascular Diabetology 2020 19:69

    Content type: Original investigation

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  27. ABO blood groups have previously been associated with cardiovascular disease (CVD) in the general population. This study aimed to investigate the potential relationship between ABO blood groups and CVD in indi...

    Authors: Erika B. Parente, Valma Harjutsalo, Markku Lehto, Carol Forsblom, Niina Sandholm and Per-Henrik Groop

    Citation: Cardiovascular Diabetology 2020 19:68

    Content type: Original investigation

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  28. We evaluated the effect of statin use on new-onset type 2 diabetes among individuals without atherosclerotic cardiovascular disease (ASCVD) using nationally representative South Korean claims data (2002–2013, ...

    Authors: Eonji Na, Sunyoung Cho, Dae Jung Kim, Junjeong Choi and Euna Han

    Citation: Cardiovascular Diabetology 2020 19:67

    Content type: Original investigation

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  29. Empagliflozin showed efficacy in controlling glycaemia, leading to reductions in HbA1c levels, weight loss and blood pressure, compared to standard treatment. Moreover, the EMPA-REG OUTCOME trial demonstrated ...

    Authors: Jolanda Sabatino, Salvatore De Rosa, Laura Tammè, Claudio Iaconetti, Sabato Sorrentino, Alberto Polimeni, Chiara Mignogna, Andrea Amorosi, Carmen Spaccarotella, Masakazu Yasuda and Ciro Indolfi

    Citation: Cardiovascular Diabetology 2020 19:66

    Content type: Original investigation

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  31. Type 2 diabetes mellitus is common in cardiovascular disease. It is associated with adverse clinical outcomes for patients who had undergone coronary artery bypass and valve operations. The aim of this study w...

    Authors: Shengwei Wang, Hao Cui, Keshan Ji, Changpeng Song, Changwei Ren, Hongchang Guo, Changsheng Zhu, Shuiyun Wang and Yongqiang Lai

    Citation: Cardiovascular Diabetology 2020 19:64

    Content type: Original investigation

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  32. Evidence of adverse clinical outcomes for non-vitamin K antagonist oral anticoagulant (NOACs) and warfarin in patients with atrial fibrillation (AF) and diabetes mellitus are limited. We investigated the effec...

    Authors: Yi-Hsin Chan, Hsin-Fu Lee, Pei-Ru Li, Jia-Rou Liu, Tze-Fan Chao, Lung-Sheng Wu, Shang-Hung Chang, Yung-Hsin Yeh, Chi-Tai Kuo, Lai-Chu See and Gregory Y. H. Lip

    Citation: Cardiovascular Diabetology 2020 19:63

    Content type: Original investigation

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  34. Sleep disturbance has been significantly associated with the incidence of cardiovascular disease (CVD) in the general population. However, despite the common prevalence of sleep disturbance in patients with ty...

    Authors: Young Choi and Jae Woo Choi

    Citation: Cardiovascular Diabetology 2020 19:61

    Content type: Original investigation

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  35. Nationwide studies on contemporary trends in incidence of diabetes-related complications in Asia are lacking. We describe trends in incident coronary heart disease (CHD), stroke, heart failure, hyperglycaemic ...

    Authors: Hongjiang Wu, Eric S. H. Lau, Aimin Yang, Ronald C. W. Ma, Alice P. S. Kong, Elaine Chow, Wing-Yee So, Juliana C. N. Chan and Andrea O. Y. Luk

    Citation: Cardiovascular Diabetology 2020 19:60

    Content type: Original investigation

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  36. To assess the prognostic role of coronary collaterals in patients with type 2 diabetes mellitus (T2DM) after successful percutaneous coronary intervention (PCI) for chronic total occlusion (CTO).

    Authors: Zhen Kun Yang, Ying Shen, Yang Dai, Xiao Qun Wang, Jian Hu, Feng Hua Ding, Rui Yan Zhang, Lin Lu and Wei Feng Shen

    Citation: Cardiovascular Diabetology 2020 19:59

    Content type: Original investigation

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  37. The triglyceride and glucose index (TyG) has been proposed as a marker of insulin resistance. This study aims to evaluate the association of the TyG index with the severity and mortality of coronavirus disease...

    Authors: Huihui Ren, Yan Yang, Fen Wang, Yongli Yan, Xiaoli Shi, Kun Dong, Xuefeng Yu and Shujun Zhang

    Citation: Cardiovascular Diabetology 2020 19:58

    Content type: Original investigation

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  38. Glucagon-like peptide-1 (GLP-1) induces diuresis and natriuresis. Previously we have shown that GLP-1 activates afferent renal nerve to increase efferent renal sympathetic nerve activity that negates the diure...

    Authors: Kenichi Katsurada, Shyam S. Nandi, Hong Zheng, Xuefei Liu, Neeru M. Sharma and Kaushik P. Patel

    Citation: Cardiovascular Diabetology 2020 19:57

    Content type: Original investigation

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  39. The intracellular ROCK signaling pathway is an important modulator of blood pressure and of cardiovascular and renal remodeling when Rho-kinase activity is increased. Besides, in preclinical models of diabetes...

    Authors: Maria Paz Ocaranza, Patricio Valderas, Jackeline Moya, Luigi Gabrielli, Iván Godoy, Samuel Córdova, Paul Mac Nab, Lorena García, Luis Farías and Jorge E. Jalil

    Citation: Cardiovascular Diabetology 2020 19:56

    Content type: Original investigation

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  42. The triglyceride-glucose (TyG) index is a marker of insulin resistance (IR) and has been associated with various metabolic syndromes, cardiovascular diseases, and cerebrovascular diseases. However, limited inf...

    Authors: Ki-Woong Nam, Hyung-Min Kwon, Han-Yeong Jeong, Jin-Ho Park, Hyuktae Kwon and Su-Min Jeong

    Citation: Cardiovascular Diabetology 2020 19:53

    Content type: Original investigation

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  43. The microvascular effects of obesity should be considered in diabetic individuals for elucidating underlying mechanisms and developing targeted therapies. This study aims to determine the effect of obesity on ...

    Authors: Li Jiang, Ke Shi, Ying-kun Guo, Yan Ren, Zhen-lin Li, Chun-chao Xia, Lei Li, Xi Liu, Lin-jun Xie, Yue Gao, Meng-ting Shen, Ming-yan Deng and Zhi-gang Yang

    Citation: Cardiovascular Diabetology 2020 19:52

    Content type: Original investigation

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  44. Despite the known association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD), whether NAFLD predicts future CVD events, especially CVD mortality, remains uncertain. We evalu...

    Authors: Jun Hyung Kim, Jin Sil Moon, Seok Joon Byun, Jun Hyeok Lee, Dae Ryong Kang, Ki Chul Sung, Jang Young Kim and Ji Hye Huh

    Citation: Cardiovascular Diabetology 2020 19:51

    Content type: Original investigation

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  45. The prognostic importance of an increased visit-to-visit blood pressure variability (BP-VVV) for the future development of micro- and macrovascular complications in type 2 diabetes has been scarcely investigat...

    Authors: Claudia R. L. Cardoso, Nathalie C. Leite and Gil F. Salles

    Citation: Cardiovascular Diabetology 2020 19:50

    Content type: Original investigation

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  46. Although more than one-third of the patients with acute heart failure (AHF) have diabetes mellitus (DM), it is unclear if DM has an adverse impact on clinical outcomes. This study compared the outcomes in pati...

    Authors: Min Gyu Kong, Se Yong Jang, Jieun Jang, Hyun-Jai Cho, Sangjun Lee, Sang Eun Lee, Kye Hun Kim, Byung-Su Yoo, Seok-Min Kang, Sang Hong Baek, Dong-Ju Choi, Eun-Seok Jeon, Jae-Joong Kim, Myeong-Chan Cho, Shung Chull Chae, Byung-Hee Oh…

    Citation: Cardiovascular Diabetology 2020 19:49

    Content type: Original investigation

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  47. Exenatide, a glucagon like peptide 1 analog, has been suggested to reduce the cardiovascular disease risk factors, such as body weight, blood pressure and subclinical atherosclerosis in patients with type 2 di...

    Authors: Jie Zhang, Tong-Zhang Xian, Ming-Xiao Wu, Chen Li, Qi Pan and Li-Xin Guo

    Citation: Cardiovascular Diabetology 2020 19:48

    Content type: Original investigation

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  48. The 5th Cardiovascular Outcome Trial (CVOT) Summit was held in Munich on October 24th–25th, 2019. As in previous years, this summit served as a reference meeting for in-depth discussions on the topic of recent...

    Authors: Oliver Schnell, Eberhard Standl, Xavier Cos, Hiddo JL Heerspink, Baruch Itzhak, Nebojsa Lalic, Michael Nauck and Antonio Ceriello

    Citation: Cardiovascular Diabetology 2020 19:47

    Content type: Commentary

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  49. The clear evidence of cardiovascular benefits in cardiovascular outcome trials of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in type 2 diabetes might suggest an effect on atherosclerotic plaque vulnera...

    Authors: Valentina Spigoni, Federica Fantuzzi, Cecilia Carubbi, Giulia Pozzi, Elena Masselli, Giuliana Gobbi, Anna Solini, Riccardo C. Bonadonna and Alessandra Dei Cas

    Citation: Cardiovascular Diabetology 2020 19:46

    Content type: Original investigation

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  50. Elevation in small dense low-density lipoprotein (sdLDL) is common in patients with diabetes mellitus (DM), which has already been reported to be associated with incidence of coronary artery disease (CAD). The...

    Authors: Jing-Lu Jin, Hui-Wen Zhang, Ye-Xuan Cao, Hui-Hui Liu, Qi Hua, Yan-Fang Li, Yan Zhang, Na-Qiong Wu, Cheng-Gang Zhu, Rui-Xia Xu, Ying Gao, Xiao-Lin Li, Chuan-Jue Cui, Geng Liu, Jing Sun, Qian Dong…

    Citation: Cardiovascular Diabetology 2020 19:45

    Content type: Original investigation

    Published on:

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