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  1. Content type: Original investigation

    As body fat composition and metabolism differ between men and women, we evaluated sex-related differences in the association among epicardial adipose tissue (EAT), secretome profile, and myocardial function of...

    Authors: Dong-Hyuk Cho, Hyung Joon Joo, Mi-Na Kim, Do-Sun Lim, Wan Joo Shim and Seong-Mi Park

    Citation: Cardiovascular Diabetology 2018 17:95

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  2. Content type: Review

    Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug metformin and a cholesterol-lowering statin. However, b...

    Authors: Mariël F. van Stee, Albert A. de Graaf and Albert K. Groen

    Citation: Cardiovascular Diabetology 2018 17:94

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  3. Content type: Original investigation

    Previous studies have documented that visceral adipose tissue is positively associated with the risk of diabetes. However, the association of subcutaneous adipose tissue with diabetes risk is still in dispute....

    Authors: Peizhu Chen, Xuhong Hou, Gang Hu, Li Wei, Lei Jiao, Hongmei Wang, Siyu Chen, Jingzhu Wu, Yuqian Bao and Weiping Jia

    Citation: Cardiovascular Diabetology 2018 17:93

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  4. Content type: Original investigation

    Angiopoietin-like protein 8 (ANGPTL8), which is a novel hormone produced in liver and adipose tissue, is involved in regulating lipid metabolism. Patients with diabetes and coronary artery disease (CAD) have r...

    Authors: Xiaolu Jiao, Jiqiang He, Yunyun Yang, Song Yang, Juan Li and Yanwen Qin

    Citation: Cardiovascular Diabetology 2018 17:92

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  5. Content type: Original investigation

    Recently, two large randomized controlled trials which only included patients with underlying cardiovascular disease (CVD) or patients at high risk for CVD showed that two sodium glucose co-transporter 2 inhib...

    Authors: Young-Gun Kim, Seung Jin Han, Dae Jung Kim, Kwan-Woo Lee and Hae Jin Kim

    Citation: Cardiovascular Diabetology 2018 17:91

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  6. Content type: Original investigation

    Raised hemoglobinA1c (HbA1c) is an indicator of pre-diabetes, which is associated with increased risk of coronary artery disease. However, the detailed morphological characteristics of non-culprit plaques in a...

    Authors: Shaotao Zhang, Jiannan Dai, Haibo Jia, Sining Hu, Hongwei Du, Ning Li, Yongpeng Zou, Yanan Zou, Shenhong Jing, Yan Wang, Rong Sun and Bo Yu

    Citation: Cardiovascular Diabetology 2018 17:90

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  7. Content type: Original investigation

    Calcium/calmodulin-dependent kinase II-delta (CaMKIIδ) activity is enhanced during hyperglycemia and has been shown to alter intracellular calcium handling in cardiomyocytes, ultimately leading to reduced card...

    Authors: Lorna J. Daniels, Rachel S. Wallace, Olivia M. Nicholson, Genevieve A. Wilson, Fiona J. McDonald, Peter P. Jones, J. Chris Baldi, Regis R. Lamberts and Jeffrey R. Erickson

    Citation: Cardiovascular Diabetology 2018 17:89

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  8. Content type: Original investigation

    Local, abdominal fat depots may be related to alterations in cardiac function and morphology due to a metabolic linkage. Thus, we aimed to determine their association with subtle cardiac changes and the potent...

    Authors: Christopher L. Schlett, Roberto Lorbeer, Carolyn Arndt, Sigrid Auweter, Jürgen Machann, Holger Hetterich, Birgit Linkohr, Wolfgang Rathmann, Annette Peters and Fabian Bamberg

    Citation: Cardiovascular Diabetology 2018 17:88

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  9. Content type: Original investigation

    Chronic low-grade inflammation and associated insulin resistance and metabolic abnormalities have been proposed as ‘common soil’ for diabetes mellitus (DM) and cardiovascular disease (CVD). This paper aimed to...

    Authors: Xue Bao, Yan Borné, Linda Johnson, Iram Faqir Muhammad, Margaretha Persson, Kaijun Niu and Gunnar Engström

    Citation: Cardiovascular Diabetology 2018 17:87

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  10. Content type: Study protocol

    Recent studies reported that sodium glucose cotransporter 2 (SGLT2) inhibitors reduced the cardiovascular morbidity and mortality in patients with type 2 diabetes mellitus (T2DM) compared to placebo in contras...

    Authors: Fumika Shigiyama, Naoki Kumashiro, Ayako Fuchigami and Takahisa Hirose

    Citation: Cardiovascular Diabetology 2018 17:86

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  11. Content type: Commentary

    Recent clinical trials investigating cardiovascular (CV) safety of newer antidiabetic agents have been rapidly and largely changing the landscape of diabetes care and providing highly important clinical inform...

    Authors: Atsushi Tanaka and Koichi Node

    Citation: Cardiovascular Diabetology 2018 17:85

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  12. Content type: Original investigation

    Advanced glycation end-products play a role in diabetic vascular complications. Their optical properties allow to estimate their accumulation in tissues by measuring the skin autofluorescence (SAF). We searche...

    Authors: C. Blanc-Bisson, F. L. Velayoudom-Cephise, A. Cougnard-Gregoire, C. Helmer, K. Rajaobelina, C. Delcourt, L. Alexandre, L. Blanco, K. Mohammedi, M. Monlun and V. Rigalleau

    Citation: Cardiovascular Diabetology 2018 17:82

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  13. Content type: Original investigation

    Patients with type 2 diabetes (T2D) face a high amputation rate. We investigated the relationship between the level of amputation and the presence of micro or macro-vascular disease and related circulating bio...

    Authors: Fabrice Schneider, Pierre-Jean Saulnier, Elise Gand, Mathieu Desvergnes, Nicolas Lefort, Eric Thorin, Nathalie Thorin-Trescases, Kamel Mohammedi, Stéphanie Ragot, Jean-Baptiste Ricco and Samy Hadjadj

    Citation: Cardiovascular Diabetology 2018 17:81

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  14. Content type: Original investigation

    Most studies linking long-term consequences of adolescent underweight and obesity are limited to men.

    Authors: Ariel Furer, Arnon Afek, Omri Orr, Liron Gershovitz, Moran Landau Rabbi, Estela Derazne, Orit Pinhas-Hamiel, Noam Fink, Adi Leiba, Amir Tirosh, Jeremy D. Kark and Gilad Twig

    Citation: Cardiovascular Diabetology 2018 17:80

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  15. Content type: Review

    Cardiovascular (CV) safety of one anti-diabetic medication over another remains partially delineated. We sought to assess the comparative effect on CV outcomes among novel anti-diabetic agents.

    Authors: Xiao-dong Zhuang, Xin He, Da-ya Yang, Yue Guo, Jian-gui He, Hai-peng Xiao and Xin-xue Liao

    Citation: Cardiovascular Diabetology 2018 17:79

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  16. Content type: Original investigation

    High-density lipoproteins (HDLs) can exert anti-atherogenic effects. On top of removing excess cholesterol through reverse cholesterol transport, HDLs play beneficial actions on endothelial function and integr...

    Authors: Daniela Lucchesi, Simona Georgiana Popa, Veronica Sancho, Laura Giusti, Monia Garofolo, Giuseppe Daniele, Laura Pucci, Roberto Miccoli, Giuseppe Penno and Stefano Del Prato

    Citation: Cardiovascular Diabetology 2018 17:78

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  17. Content type: Original investigation

    Cardiovascular risk stratification is complex in type 1 diabetes. We hypothesised that traditional and diabetes-specific cardiovascular risk factors were prevalent and strongly associated with cardiovascular d...

    Authors: Anthony Pease, Arul Earnest, Sanjeeva Ranasinha, Natalie Nanayakkara, Danny Liew, Natalie Wischer, Sofianos Andrikopoulos and Sophia Zoungas

    Citation: Cardiovascular Diabetology 2018 17:77

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  18. Content type: Original investigation

    We investigated whether and to what extent stenosis of predominant collateral donor artery (PCDA) affects coronary collateral flow in relation to blood pressure (BP) in type 2 diabetic patients with chronic to...

    Authors: Ying Shen, Zhen Kun Yang, Jian Hu, Xiao Qun Wang, Yang Dai, Su Zhang, Rui Yan Zhang, Lin Lu, Feng Hua Ding and Wei Feng Shen

    Citation: Cardiovascular Diabetology 2018 17:76

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  19. Content type: Original Investigation

    Inflammation has been recognized as a key feature of both type 2 diabetes mellitus (T2DM) and atherosclerosis. However, the relationships between circulating levels of novel adipose tissue-derived inflammatory...

    Authors: Wei Yang, Yun Li, Jie-Yu Wang, Rui Han and Li Wang

    Citation: Cardiovascular Diabetology 2018 17:75

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  20. Content type: Commentary

    Prevention and treatment strategies for heart failure (HF) in diabetes have not been fully established, at least partly due to lack of recognition of a pathological link between the two and effective antidiabe...

    Authors: Atsushi Tanaka and Koichi Node

    Citation: Cardiovascular Diabetology 2018 17:74

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  21. Content type: Original investigation

    Type 2 diabetes mellitus (T2DM) greatly increases the risks of cardiovascular disease and heart failure. In particular, left ventricular diastolic dysfunction that develops from the early stages of T2DM is an ...

    Authors: Daisuke Matsutani, Masaya Sakamoto, Yosuke Kayama, Norihiko Takeda, Ryuzo Horiuchi and Kazunori Utsunomiya

    Citation: Cardiovascular Diabetology 2018 17:73

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  22. Content type: Original investigation

    Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) are approved drugs for the treatment of hyperglycemia in patients with type 2 diabetes. These effects are mainly mediated by inhibiting endogenous glucagon-...

    Authors: Fausto Chiazza, Harald Tammen, Hiranya Pintana, Grazyna Lietzau, Massimo Collino, Thomas Nyström, Thomas Klein, Vladimer Darsalia and Cesare Patrone

    Citation: Cardiovascular Diabetology 2018 17:60

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  23. Content type: Original investigation

    Type 2 diabetes mellitus (T2DM) is an independent risk factor of cardiovascular disease (CVD), however, the underlying mechanisms are largely unknown. Using non-atherosclerotic internal thoracic arteries (ITAs...

    Authors: Lasse Bach Steffensen, Søren Feddersen, Simone Rørdam Preil and Lars Melholt Rasmussen

    Citation: Cardiovascular Diabetology 2018 17:72

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  24. Content type: Original investigation

    Early glucose lowering intervention in subjects with type 2 diabetes mellitus was demonstrated to be beneficial in terms of micro- and macrovascular risk reduction. However, most of currently ongoing cardiovas...

    Authors: Norbert J. Tripolt, Felix Aberer, Regina Riedl, Jasmin Url, Gudrun Dimsity, Andreas Meinitzer, Tatjana Stojakovic, Faisal Aziz, Ronald Hödl, Gabriele Brachtl, Dirk Strunk, Marianne Brodmann, Franz Hafner and Harald Sourij

    Citation: Cardiovascular Diabetology 2018 17:71

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  25. Content type: Original investigation

    To estimate the risk of developing long-term major cardiovascular and renal complications in relation to levels of body mass index (BMI) in a population of White European (WE), African-Caribbean (AC), and Sout...

    Authors: Ebenezer S. Owusu Adjah, Srikanth Bellary, Wasim Hanif, Kiran Patel, Kamlesh Khunti and Sanjoy K. Paul

    Citation: Cardiovascular Diabetology 2018 17:70

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  26. Content type: Original investigation

    Elevated retinol-binding protein 4 (RBP4) levels may contribute to the development of metabolic abnormalities, but prospective studies evaluating the association between childhood RBP4 levels and metabolic syn...

    Authors: Ge Li, Issy C. Esangbedo, Lu Xu, Junling Fu, Lujiao Li, Dan Feng, Lanwen Han, Xinhua Xiao, Mingyao Li, Jie Mi, Ming Li, Shan Gao and Steven M. Willi

    Citation: Cardiovascular Diabetology 2018 17:69

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  27. Content type: Original investigation

    Epidemiological studies show that maternal diabetes predisposes offspring to cardiovascular and metabolic disorders. However, the precise mechanisms for the underlying penetrance and disease predisposition rem...

    Authors: Radka Cerychova, Romana Bohuslavova, Frantisek Papousek, David Sedmera, Pavel Abaffy, Vladimir Benes, Frantisek Kolar and Gabriela Pavlinkova

    Citation: Cardiovascular Diabetology 2018 17:68

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  28. Content type: Original investigation

    Coronary artery calcified plaque (CAC) is strongly predictive of cardiovascular disease (CVD) events and mortality, both in general populations and individuals with type 2 diabetes at high risk for CVD. CAC is...

    Authors: Laura M. Raffield, Amanda J. Cox, Michael H. Criqui, Fang-Chi Hsu, James G. Terry, Jianzhao Xu, Barry I. Freedman, J. Jeffrey Carr and Donald W. Bowden

    Citation: Cardiovascular Diabetology 2018 17:67

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  29. Content type: Original investigation

    Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2 diabetes. The aim of the study was to assess the associat...

    Authors: Marc Carbonell, Esmeralda Castelblanco, Xavier Valldeperas, Àngels Betriu, Alícia Traveset, Minerva Granado-Casas, Marta Hernández, Federico Vázquez, Mariona Martín, Esther Rubinat, Albert Lecube, Josep Franch-Nadal, Elvira Fernández, Manel Puig-Domingo, Angelo Avogaro, Núria Alonso…

    Citation: Cardiovascular Diabetology 2018 17:66

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  30. Content type: Original investigation

    Type 2 diabetes is associated with endothelial dysfunction leading to cardiovascular disease. CD34+ endothelial Progenitor Cells (EPCs) are responsible for endothelial repair and neo-angiogenesis and can be us...

    Authors: Fiona J. Dore, Cleyton C. Domingues, Neeki Ahmadi, Nabanita Kundu, Yana Kropotova, Sara Houston, Carol Rouphael, Aytan Mammadova, Linda Witkin, Anamil Khiyami, Richard L. Amdur and Sabyasachi Sen

    Citation: Cardiovascular Diabetology 2018 17:65

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  31. Content type: Original investigation

    Exercise training is considered a cornerstone in the management of type 2 diabetes, which is associated with impaired endothelial function. However, the association of exercise training with endothelial functi...

    Authors: Shanhu Qiu, Xue Cai, Han Yin, Zilin Sun, Martina Zügel, Jürgen Michael Steinacker and Uwe Schumann

    Citation: Cardiovascular Diabetology 2018 17:64

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  32. Content type: Original investigation

    Cardiovascular disease (CVD) is a leading cause of death among adults with type 2 diabetes mellitus (T2D). We recently reported that glycemic control in patients with T2D can be significantly improved through ...

    Authors: Nasir H. Bhanpuri, Sarah J. Hallberg, Paul T. Williams, Amy L. McKenzie, Kevin D. Ballard, Wayne W. Campbell, James P. McCarter, Stephen D. Phinney and Jeff S. Volek

    Citation: Cardiovascular Diabetology 2018 17:56

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  33. Content type: Original investigation

    The aim of the present study was to evaluate the prognostic value of the Stanniocalcin-2/PAPP-A/IGFBP-4 axis in patients with ST-segment elevation myocardial infarction (STEMI).

    Authors: Germán Cediel, Ferran Rueda, Claus Oxvig, Teresa Oliveras, Carlos Labata, Oriol de Diego, Marc Ferrer, M. Cruz Aranda-Nevado, Judith Serra-Gregori, Julio Núñez, Cosme García and Antoni Bayes-Genis

    Citation: Cardiovascular Diabetology 2018 17:63

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  34. Content type: Original investigation

    Type 2 diabetes (T2D) is associated with generalized vascular dysfunction characterized by increases in large artery stiffness, endothelial dysfunction, and vascular smooth muscle dysfunction. Sodium glucose c...

    Authors: Dustin M. Lee, Micah L. Battson, Dillon K. Jarrell, Shuofei Hou, Kayl E. Ecton, Tiffany L. Weir and Christopher L. Gentile

    Citation: Cardiovascular Diabetology 2018 17:62

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  35. Content type: Original investigation

    Patients with type 1 diabetes are more at risk of coronary artery disease than the general population. Although evidence points to a genetic risk there have been no study investigating genetic risk factors of ...

    Authors: Romain Charmet, Seamus Duffy, Sareh Keshavarzi, Beata Gyorgy, Michel Marre, Peter Rossing, Amy Jayne McKnight, Alexander P. Maxwell, Tarun veer Singh Ahluwalia, Andrew D. Paterson, David-Alexandre Trégouët and Samy Hadjadj

    Citation: Cardiovascular Diabetology 2018 17:61

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  36. Content type: Review

    Multiple population based analyses have demonstrated a high incidence of cardiovascular disease (CVD) and cardiovascular (CV) mortality in subjects with T2DM that reduces life expectancy by as much as 15 years...

    Authors: Annayya R. Aroor, Camila Manrique-Acevedo and Vincent G. DeMarco

    Citation: Cardiovascular Diabetology 2018 17:59

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  37. Content type: Original investigation

    Type 2 diabetes mellitus (T2D) is associated with the development of left ventricular systolic dysfunction (LVSD) and heart failure with reduced ejection fraction (HFrEF). T2D patients with LVSD are at higher ...

    Authors: Selma Bouthoorn, Aisha Gohar, Gideon Valstar, Hester M. den Ruijter, J. B. Reitsma, Arno W. Hoes and Frans H. Rutten

    Citation: Cardiovascular Diabetology 2018 17:58

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  38. Content type: Review

    Cardiovascular disease (CVD) is the leading cause of mortality in people with type 2 diabetes mellitus (T2DM), yet a significant proportion of the disease burden cannot be accounted for by conventional cardiov...

    Authors: W. David Strain and P. M. Paldánius

    Citation: Cardiovascular Diabetology 2018 17:57

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  39. Content type: Original investigation

    Sarcopenic obesity, defined as reduced skeletal muscle mass and power with increased adiposity, was reported to be associated with cardiovascular disease risks in previous cross-sectional studies. Whole body d...

    Authors: Tatsuya Fukuda, Ryotaro Bouchi, Takato Takeuchi, Kazutaka Tsujimoto, Isao Minami, Takanobu Yoshimoto and Yoshihiro Ogawa

    Citation: Cardiovascular Diabetology 2018 17:55

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  40. Content type: Original investigation

    To evaluate real-world patient characteristics, medication use, and health care utilization patterns in patients with type 2 diabetes with established cardiovascular disease (CVD).

    Authors: Kevin M. Pantalone, Anita D. Misra-Hebert, Todd M. Hobbs, Xinge Ji, Sheldon X. Kong, Alex Milinovich, Wayne Weng, Janine Bauman, Rahul Ganguly, Bartolome Burguera, Michael W. Kattan and Robert S. Zimmerman

    Citation: Cardiovascular Diabetology 2018 17:54

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  41. Content type: Original investigation

    It has been suggested that liraglutide could have an impact on glucose and lipid metabolism disorder and adhesion molecule activation, which may play important roles in the vascular damage of diabetes. In this...

    Authors: Xiao-min Chen, Wen-qiang Zhang, Yuan Tian, Li-fen Wang, Chan-chan Chen and Chuan-mei Qiu

    Citation: Cardiovascular Diabetology 2018 17:53

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  42. Content type: Original investigation

    Cardiovascular protection following empagliflozin therapy is not entirely attributable to the glucose lowering effect. Increased hematocrit might influence the shear stress that is the main force acting on the...

    Authors: Concetta Irace, Francesco Casciaro, Faustina Barbara Scavelli, Rosa Oliverio, Antonio Cutruzzolà, Claudio Cortese and Agostino Gnasso

    Citation: Cardiovascular Diabetology 2018 17:52

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  43. Content type: Original investigation

    The effect of change in blood glucose levels on the risk of cardiovascular disease among individuals without diabetes is currently unclear. We aimed to examine the association of change in fasting serum glucos...

    Authors: Gyeongsil Lee, Sung Min Kim, Seulggie Choi, Kyuwoong Kim, Su-Min Jeong, Joung Sik Son, Jae-Moon Yun and Sang Min Park

    Citation: Cardiovascular Diabetology 2018 17:51

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  44. Content type: Original investigation

    The urinary proteomic classifier CKD273 has shown promise for prediction of progressive diabetic nephropathy (DN). Whether it is also a determinant of mortality and cardiovascular disease in patients with micr...

    Authors: Gemma E. Currie, Bernt Johan von Scholten, Sheon Mary, Jose-Luis Flores Guerrero, Morten Lindhardt, Henrik Reinhard, Peter K. Jacobsen, William Mullen, Hans-Henrik Parving, Harald Mischak, Peter Rossing and Christian Delles

    Citation: Cardiovascular Diabetology 2018 17:50

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  45. Content type: Correction

    The author found errors in Table 1 after publication of the original article [1].

    Authors: Núria Alonso, Alicia Traveset, Esther Rubinat, Emilio Ortega, Nuria Alcubierre, Jordi Sanahuja, Marta Hernández, Angels Betriu, Carmen Jurjo, Elvira Fernández and Didac Mauricio

    Citation: Cardiovascular Diabetology 2018 17:49

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    The original article was published in Cardiovascular Diabetology 2015 14:33

  46. Content type: Original investigation

    Proprotein convertase subtilisin/kexin type 9 (PCSK9), a major regulator of cholesterol homeostasis, is associated with glucose metabolism. Liraglutide, a glucagon-like peptide-1 receptor agonist, can increase...

    Authors: Sheng-Hua Yang, Rui-Xia Xu, Chuan-Jue Cui, Yin Wang, Ying Du, Zhi-Guo Chen, Yu-Hong Yao, Chun-Yan Ma, Cheng-Gang Zhu, Yuan-Lin Guo, Na-Qiong Wu, Jing Sun, Bu-Xing Chen and Jian-Jun Li

    Citation: Cardiovascular Diabetology 2018 17:48

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  47. Content type: Original investigation

    Diabetic complications may be associated with impaired time-dependent glycemic control. Therefore, long-term glycemic variability, assessed by variations in haemoglobin A1c (HbA1c), may be a potential risk fac...

    Authors: Jian-bin Su, Li-hua Zhao, Xiu-lin Zhang, Hong-li Cai, Hai-yan Huang, Feng Xu, Tong Chen and Xue-qin Wang

    Citation: Cardiovascular Diabetology 2018 17:47

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  48. Content type: Original investigation

    In the last decade, several studies have reported an unexpected and seemingly paradoxical inverse correlation between BMI and incidence of cardiovascular diseases. This so called “obesity paradox effect” has b...

    Authors: Valentina Rovella, Lucia Anemona, Marina Cardellini, Manuel Scimeca, Andrea Saggini, Giuseppe Santeusanio, Elena Bonanno, Manuela Montanaro, Iacopo Maria Legramante, Arnaldo Ippoliti, Nicola Di Daniele, Massimo Federici and Alessandro Mauriello

    Citation: Cardiovascular Diabetology 2018 17:46

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  49. Content type: Original investigation

    Vascular calcifications are associated with a three- to fourfold increased risk of cardiovascular disease (CVD) and are highly prevalent in type 2 diabetes patients. Emerging evidence indicates that vascular c...

    Authors: Sabine R. Zwakenberg, Yvonne T. van der Schouw, Casper G. Schalkwijk, Annemieke M. W. Spijkerman and Joline W. J. Beulens

    Citation: Cardiovascular Diabetology 2018 17:45

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