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  1. Content type: Original investigation

    Cardiovascular disease (CVD) is a major cause of mortality in type 1 diabetes (T1D). A pro-calcific drift of circulating monocytes has been linked to vascular calcification and is marked by the surface express...

    Authors: Ernesto Maddaloni, Yu Xia, Kyoungmin Park, Stephanie D’Eon, Liane J. Tinsley, Ronald St-Louis, Mogher Khamaisi, Qian Li, George L. King and Hillary A. Keenan

    Citation: Cardiovascular Diabetology 2017 16:116

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  2. Content type: Original investigation

    Good glycaemic control in type 2 diabetes (T2DM) protects the microcirculation. Current guidelines suggest glycaemic targets be relaxed in advanced diabetes. We explored whether disease duration or pre-existin...

    Authors: F. Casanova, D. D. Adingupu, F. Adams, K. M. Gooding, H. C. Looker, K. Aizawa, F. Dove, S. Elyas, J. J. F. Belch, P. E. Gates, R. C. Littleford, M. Gilchrist, H. M. Colhoun, A. C. Shore, F. Khan and W. D. Strain

    Citation: Cardiovascular Diabetology 2017 16:114

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  3. Content type: Original investigation

    The role of advanced glycation end products (AGEs) and their soluble receptor (sRAGE) on the progression and prognosis of acute heart failure (HF) was analysed in relation with metabolic parameters as body com...

    Authors: Beatriz Paradela-Dobarro, Ángel Fernández-Trasancos, Diana Bou-Teen, Sonia Eiras, Rocío González-Ferreiro, Rosa M. Agra, Alfonso Varela-Román, Ana I. Castro-Pais, Marcos C. Carreira, Felipe F. Casanueva, Ezequiel Álvarez and José R. González-Juanatey

    Citation: Cardiovascular Diabetology 2017 16:115

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  4. Content type: Review

    In the Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus (SAVOR) trial in patients with type 2 diabetes mellitus (T2D) at high risk of cardiovascular (CV) disease, saxagli...

    Authors: Pia S. Pollack, Kristina D. Chadwick, David M. Smith, Martin Billger, Boaz Hirshberg, Nayyar Iqbal and David W. Boulton

    Citation: Cardiovascular Diabetology 2017 16:113

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  5. Content type: Original investigation

    Omarigliptin is a once-weekly (q.w.) oral DPP-4 inhibitor that is approved for the treatment of patients with type 2 diabetes mellitus (T2DM) in Japan. To support approval of omarigliptin in the United States,...

    Authors: Ira Gantz, Menghui Chen, Shailaja Suryawanshi, Catherine Ntabadde, Sukrut Shah, Edward A. O’Neill, Samuel S. Engel, Keith D. Kaufman and Eseng Lai

    Citation: Cardiovascular Diabetology 2017 16:112

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  6. Content type: Original investigation

    Type 2 diabetes mellitus (T2DM) might aggravate the carotid plaque vulnerability, and increase the risk for ischemic stroke. Few studies reported the acute stroke subtype with carotid plaque characteristics in...

    Authors: Beibei Sun, Xiao Li, Xiaosheng Liu, Xiaoqian Ge, Qing Lu, Xihai Zhao, Jun Pu, Jianrong Xu and Huilin Zhao

    Citation: Cardiovascular Diabetology 2017 16:111

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  7. Content type: Original investigation

    Purpose: to establish if exercise training improves clinical outcomes in people with metabolic syndrome (MetS). Registered with PROSPERO international prospective register of systemati...

    Authors: C. Ostman, N. A. Smart, D. Morcos, A. Duller, W. Ridley and D. Jewiss

    Citation: Cardiovascular Diabetology 2017 16:110

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  8. Content type: Original investigation

    Secreted frizzled-related protein (Sfrp)5 has beneficial effects on insulin sensitivity, inflammation and cardiovascular risk in different mouse models, but its relevance for cardiometabolic diseases in humans...

    Authors: Maren Carstensen-Kirberg, Julia M. Kannenberg, Cornelia Huth, Christa Meisinger, Wolfgang Koenig, Margit Heier, Annette Peters, Wolfgang Rathmann, Michael Roden, Christian Herder and Barbara Thorand

    Citation: Cardiovascular Diabetology 2017 16:109

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  9. Content type: Original investigation

    The triglyceride glucose (TyG) index has been considered a simple surrogate marker of insulin resistance. However, few studies have investigated the relationship between the TyG index and coronary artery calci...

    Authors: Min Kyung Kim, Chul Woo Ahn, Shinae Kang, Ji Sun Nam, Kyung Rae Kim and Jong Suk Park

    Citation: Cardiovascular Diabetology 2017 16:108

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  10. Content type: Original investigation

    Statins may increase the risk of new-onset diabetes and adversely affect glycaemic control, but their effects on the glycemic response and mortality outcomes following commencement of insulin therapy in patien...

    Authors: Uchenna Anyanwagu, Jil Mamza, Richard Donnelly and Iskandar Idris

    Citation: Cardiovascular Diabetology 2017 16:107

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  11. Content type: Original investigation

    The relationship between fibroblast growth factor 21 (FGF21) and cardiovascular disease has been well established in recent studies. This study aimed to investigate the relationship between FGF21 and left vent...

    Authors: Yun Shen, Xueli Zhang, Xiaoping Pan, Yiting Xu, Qin Xiong, Zhigang Lu, Xiaojing Ma, Yuqian Bao and Weiping Jia

    Citation: Cardiovascular Diabetology 2017 16:106

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  12. Content type: Original investigation

    The relationship between changes in proteinuria and myocardial infarction (MI) remains unclear in people with diabetes or pre-diabetes. We aimed to evaluate the predictive value and independent role of changes...

    Authors: Anxin Wang, Yang Sun, Xiaoxue Liu, Zhaoping Su, Junjuan Li, Yanxia Luo, Shuohua Chen, Jianli Wang, Xia Li, Zhan Zhao, Huiping Zhu, Shouling Wu and Xiuhua Guo

    Citation: Cardiovascular Diabetology 2017 16:104

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    The Erratum to this article has been published in Cardiovascular Diabetology 2017 16:117

  13. Content type: Original investigation

    Diabetes has been reported to be associated with an increased relative risk for mortality, with estimates ranging from 1.1 to 2.1. Findings are inconsistent regarding modification of the risk by gender and by ...

    Authors: Inbar Zucker, Tamy Shohat, Rachel Dankner and Gabriel Chodick

    Citation: Cardiovascular Diabetology 2017 16:105

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  14. Content type: Original investigation

    We aimed to investigate the efficacy of ascorbic acid and acetylsalicylic acid among type II diabetes mellitus patients using metformin (only) for diabetes management therapy.

    Authors: Syed Wasif Gillani, Syed Azhar Syed Sulaiman, Mohi Iqbal Mohammad Abdul and Mirza R. Baig

    Citation: Cardiovascular Diabetology 2017 16:103

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  15. Content type: Original investigation

    High admission blood glucose (ABG) level has been associated with a poor short-term outcome among non-diabetic patients with heart failure (HF). We aimed to investigate the association between ABG levels and l...

    Authors: Osnat Itzhaki Ben Zadok, Ran Kornowski, Ilan Goldenberg, Robert Klempfner, Yoel Toledano, Yitschak Biton, Enrique Z. Fisman, Alexander Tenenbaum, Gregory Golovchiner, Ehud Kadmon, Alexander Omelchenko, Tuvia Ben Gal and Alon Barsheshet

    Citation: Cardiovascular Diabetology 2017 16:102

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  16. Content type: Original investigation

    Secondary prevention of cardiovascular disease (CVD) has improved immensely during the past decade but controversies persist on cardiovascular benefits among women with diabetes. We investigated 11-year trends...

    Authors: Anthony A. Laverty, Alex Bottle, Sung-Hee Kim, Bhakti Visani, Azeem Majeed, Christopher Millett and Eszter P. Vamos

    Citation: Cardiovascular Diabetology 2017 16:100

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  17. Content type: Original investigation

    High mobility group box-1 (HMGB-1) is a nuclear protein also acting as inflammatory mediator, whilst osteoprotegerin (OPG), member of tumor necrosis factor receptor superfamily, is indicated as marker of vascu...

    Authors: Silvia Giovannini, Giovanni Tinelli, Federico Biscetti, Giuseppe Straface, Flavia Angelini, Dario Pitocco, Luciana Mucci, Raffaele Landolfi and Andrea Flex

    Citation: Cardiovascular Diabetology 2017 16:99

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  18. Content type: Original investigation

    Previously, we have reported that daily glucose fluctuations could affect coronary plaque vulnerability, but the underlying mechanisms remained unclear. This study sought to investigate the impact of CD14++CD16+ ...

    Authors: Naofumi Yoshida, Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Masaru Kuroda, Daisuke Terashita, Hachidai Takahashi, Kazuhiko Sakaguchi, Yushi Hirota, Takuo Emoto, Hilman Zulkifli Amin, Taiji Mizoguchi, Tomohiro Hayashi, Naoto Sasaki, Tomoya Yamashita, Wataru Ogawa…

    Citation: Cardiovascular Diabetology 2017 16:96

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  19. Content type: Original investigation

    Neutrophil gelatinase-associated lipocalin (NGAL), an acute phase protein released by neutrophils, has been described as biomarker of inflammatory states. Type 2 diabetes mellitus (T2DM) is characterized by in...

    Authors: W. Eilenberg, S. Stojkovic, A. Piechota-Polanczyk, A. Kaider, N. Kozakowski, W. J. Weninger, J. Nanobachvili, J. Wojta, I. Huk, S. Demyanets and C. Neumayer

    Citation: Cardiovascular Diabetology 2017 16:98

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  20. Content type: Original investigation

    Acute myocardial infarction (AMI) patients with type 2 diabetes mellitus are known to present with multiple vessel lesions during coronary angiography. The underlying mechanism remains elusive and there is a s...

    Authors: Jianqing She, Yangyang Deng, Yue Wu, Yulong Xia, Hongbing Li, Xiao Liang, Rui Shi and Zuyi Yuan

    Citation: Cardiovascular Diabetology 2017 16:97

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  21. Content type: Original investigation

    Newer oral antidiabetic drug classes are expanding treatment options for type 2 diabetes mellitus (T2DM); however, concerns remain. The objective was to assess relative risk of heart failure hospitalization of...

    Authors: Santosh Gautam, Abiy Agiro, John Barron, Thomas Power, Harry Weisman and Jeff White

    Citation: Cardiovascular Diabetology 2017 16:93

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  22. Content type: Original investigation

    LADA is probably the most prevalent form of autoimmune diabetes. Nevertheless, there are few data about cardiovascular disease in this group of patients. The aim of this study was to investigate the frequency ...

    Authors: Marta Hernández, Carolina López, Jordi Real, Joan Valls, Emilio Ortega-Martinez de Victoria, Federico Vázquez, Esther Rubinat, Minerva Granado-Casas, Nuria Alonso, Teresa Molí, Angels Betriu, Albert Lecube, Elvira Fernández, Richard David Leslie and Dídac Mauricio

    Citation: Cardiovascular Diabetology 2017 16:94

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  23. Content type: Original investigation

    Microvascular disease is associated with a high risk of macrovascular events in patients with type 2 diabetes, but the impact of macrovascular disease on the risk of microvascular events remains unknown. We so...

    Authors: Kamel Mohammedi, Mark Woodward, Michel Marre, Stephen Colagiuri, Mark Cooper, Stephen Harrap, Giuseppe Mancia, Neil Poulter, Bryan Williams, Sophia Zoungas and John Chalmers

    Citation: Cardiovascular Diabetology 2017 16:95

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  24. Content type: Original investigation

    A previous genome-wide association study showed that a genetic variant of sortilin was associated with the risk of coronary artery disease (CAD). However, the role of circulating sortilin is still unknown. We ...

    Authors: Tae Jung Oh, Chang Ho Ahn, Bo-Rahm Kim, Kyoung Min Kim, Jae Hoon Moon, Soo Lim, Kyong Soo Park, Cheong Lim, HakChul Jang and Sung Hee Choi

    Citation: Cardiovascular Diabetology 2017 16:92

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  25. Content type: Erratum

    Authors: Yu-Ming Chang, Chih-Chung Shiao, Ya-Ting Huang, I-Ling Chen, Chuan-Lan Yang, Show-Chin Leu, Hung-Li Su, Jsun-Liang Kao, Shih-Ching Tsai, Rong-Na Jhen and Ching-Cherng Uen

    Citation: Cardiovascular Diabetology 2017 16:90

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    The original article was published in Cardiovascular Diabetology 2016 15:16

  26. Content type: Original investigation

    To evaluate symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA) as risk markers of cardiovascular disease, all-cause mortality and deterioration in renal function in a well characterised t...

    Authors: Emilie H. Zobel, Bernt Johan von Scholten, Henrik Reinhard, Frederik Persson, Tom Teerlink, Tine W. Hansen, Hans-Henrik Parving, Peter K. Jacobsen and Peter Rossing

    Citation: Cardiovascular Diabetology 2017 16:88

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  27. Content type: Original investigation

    Previous studies regarding the cardioprotective effects of dipeptidyl peptidase 4 (DPP-4) inhibitors have not provided sufficient evidence of a relationship between DPP-4 inhibition and actual cardiovascular o...

    Authors: Mei-Tzu Wang, Sheng-Che Lin, Pei-Ling Tang, Wang-Ting Hung, Chin-Chang Cheng, Jin-Shiou Yang, Hong-Tai Chang, Chun-Peng Liu, Guang-Yuan Mar and Wei-Chun Huang

    Citation: Cardiovascular Diabetology 2017 16:89

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  28. Content type: Original investigation

    Omentin-1, also known as Intelectin-1 (ITLN1), is an adipokine with plasma levels associated with diabetes, obesity, and coronary artery disease. Recent studies suggest that ITLN1 can mitigate myocardial ische...

    Authors: Louis A. Saddic, Sarah M. Nicoloro, Olga T. Gupta, Michael P. Czech, Joshua Gorham, Stanton K. Shernan, Christine E. Seidman, Jon G. Seidman, Sary F. Aranki, Simon C. Body, Timothy P. Fitzgibbons and Jochen D. Muehlschlegel

    Citation: Cardiovascular Diabetology 2017 16:87

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  29. Content type: Original investigation

    Little is known about clinical associations between glucose fluctuations including hypoglycemia, heart rate variability (HRV), and the activity of the sympathetic nervous system (SNS) in patients with acute ph...

    Authors: Michio Shimabukuro, Atsushi Tanaka, Masataka Sata, Kazuoki Dai, Yoshisato Shibata, Yohei Inoue, Hiroki Ikenaga, Shinji Kishimoto, Kozue Ogasawara, Akira Takashima, Toshiyuki Niki, Osamu Arasaki, Koichi Oshiro, Yutaka Mori, Masaharu Ishihara and Koichi Node

    Citation: Cardiovascular Diabetology 2017 16:86

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  30. Content type: Original investigation

    Recent studies reported that sodium glucose cotransporter 2 (SGLT2) inhibitors can potentially reduce the risk of cardiovascular mortality in patients with type 2 diabetes mellitus (T2DM). However, there is li...

    Authors: Fumika Shigiyama, Naoki Kumashiro, Masahiko Miyagi, Kayoko Ikehara, Eiichiro Kanda, Hiroshi Uchino and Takahisa Hirose

    Citation: Cardiovascular Diabetology 2017 16:84

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  31. Content type: Original investigation

    To investigate the association between diabetic retinopathy (DR) and myocardial dysfunction in patients with type 2 diabetes and dilated cardiomyopathy (dCMP).

    Authors: Yoo-Ri Chung, Se-Jun Park, Ka Young Moon, Seoyoung Annie Choi, Hong-Seok Lim, Sung Wook Park, Jeong Hun Kim and Kihwang Lee

    Citation: Cardiovascular Diabetology 2017 16:82

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  32. Content type: Original investigation

    Emerging evidence suggests that specific (poly)phenols may constitute new preventative strategies to counteract cell oxidative stress and myocardial tissue inflammation, which have a key role in the patho-phys...

    Authors: Monia Savi, Leonardo Bocchi, Pedro Mena, Margherita Dall’Asta, Alan Crozier, Furio Brighenti, Donatella Stilli and Daniele Del Rio

    Citation: Cardiovascular Diabetology 2017 16:80

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  33. Content type: Original investigation

    Patients with type 1 diabetes (T1D) are at increased risk of cardiovascular disease (CVD). Measures of high-density lipoprotein (HDL) function provide a better risk estimate for future CVD events than serum le...

    Authors: Martin Heier, Mark S. Borja, Cathrine Brunborg, Ingebjørg Seljeflot, Hanna Dis Margeirsdottir, Kristian F. Hanssen, Knut Dahl-Jørgensen and Michael N. Oda

    Citation: Cardiovascular Diabetology 2017 16:85

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  34. Content type: Original investigation

    Red blood cell distribution width (RDW) is an established prognostic marker in acute and chronic heart failure (HF). Recent studies have pointed out a link among RDW, diabetes mellitus (DM) and inflammation. W...

    Authors: Andrew Xanthopoulos, Gregory Giamouzis, Andreas Melidonis, Takeshi Kitai, Efi Paraskevopoulou, Pinelopi Paraskevopoulou, Sotirios Patsilinakos, Filippos Triposkiadis and John Skoularigis

    Citation: Cardiovascular Diabetology 2017 16:81

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  35. Content type: Original investigation

    Although Japanese–Americans and native Japanese share the same genetic predispositions, they live different lifestyles, resulting in insulin resistance in Japanese–Americans. We investigated whether the quanti...

    Authors: Mitsunobu Kubota, Masayasu Yoneda, Norikazu Maeda, Haruya Ohno, Kenji Oki, Tohru Funahashi, Iichiro Shimomura and Noboru Hattori

    Citation: Cardiovascular Diabetology 2017 16:83

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  36. Content type: Original investigation

    Albuminuria is an established marker for endothelial dysfunction and cardiovascular risk in diabetes and prediabetes. Exercise induced albuminuria (EiA) appears earlier and may be a more sensitive biomarker fo...

    Authors: Rafael Y. Brzezinski, Inbal Etz-Hadar, Ayelet Grupper, Michal Ehrenwald, Itzhak Shapira, David Zeltser, Shlomo Berliner, Ori Rogowski, Roy Eldor and Shani Shenhar-Tsarfaty

    Citation: Cardiovascular Diabetology 2017 16:79

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  37. Content type: Original investigation

    Poor glycemic control is associated with impaired left ventricular (LV) diastolic function in patients with type 2 diabetes mellitus (T2DM). Inappropriate LV mass increase and accelerated aortic stiffening wer...

    Authors: Michaela Kozakova, Carmela Morizzo, Alan G. Fraser and Carlo Palombo

    Citation: Cardiovascular Diabetology 2017 16:78

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  38. Content type: Review

    The increasing prevalence of atherosclerosis has become a worldwide health concern. Although significant progress has been made in the understanding of atherosclerosis pathogenesis, the underlying mechanisms a...

    Authors: Lihua Duan, Xiaoquan Rao, Chang Xia, Sanjay Rajagopalan and Jixin Zhong

    Citation: Cardiovascular Diabetology 2017 16:76

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  39. Content type: Original investigation

    Recently, basic and clinical studies have provided evidence supporting the relationship between circulating levels of fibroblast growth factor (FGF) 23 and the development of atherosclerosis. Given that diabet...

    Authors: Xingxing He, Xiang Hu, Xiaojing Ma, Hang Su, Lingwen Ying, Jiahui Peng, Xiaoping Pan, Yuqian Bao, Jian Zhou and Weiping Jia

    Citation: Cardiovascular Diabetology 2017 16:77

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  40. Content type: Original investigation

    Type 2 diabetes mellitus (T2DM) is a multi factorial disease, affecting clinical outcomes in failing heart patients treated by cardiac resynchronization therapy with a defibrillator (CRT-d).

    Authors: Celestino Sardu, Michelangela Barbieri, Matteo Santamaria, Valerio Giordano, Cosimo Sacra, Pasquale Paolisso, Alessandro Spirito, Raffaele Marfella, Giuseppe Paolisso and Maria Rosaria Rizzo

    Citation: Cardiovascular Diabetology 2017 16:75

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  41. Content type: Original investigation

    Dipeptidyl peptidase-4 (DPP4) regulates blood glucose levels and inflammation, and it is also implicated in the pathophysiological process of myocardial infarction (MI). Plasma DPP4 activity (DPP4a) may provid...

    Authors: Jing-Wei Li, Yun-Dai Chen, Wei-Ren Chen, Qi You, Bo Li, Hao Zhou, Ying Zhang and Tian-Wen Han

    Citation: Cardiovascular Diabetology 2017 16:72

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  42. Content type: Original investigation

    In Phase 2/3 studies of basal insulin peglispro (BIL) compared to insulin glargine, patients with type 1 or type 2 diabetes previously treated with insulin and randomized to BIL had an increase in serum trigly...

    Authors: Trevor J. Orchard, Bertrand Cariou, Margery A. Connelly, James D. Otvos, Shuyu Zhang, Caryl J. Antalis, Tibor Ivanyi and Byron J. Hoogwerf

    Citation: Cardiovascular Diabetology 2017 16:73

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  43. Content type: Original investigation

    We aimed to investigate the impact of diabetes duration and carotid artery stenosis (CAS) on the occurrence of major adverse cardiovascular events (MACE) in patients with type 2 diabetes mellitus (T2DM) withou...

    Authors: Minsu Noh, Hyunwook Kwon, Chang Hee Jung, Sun U. Kwon, Min Seon Kim, Woo Je Lee, Joong Yeol Park, Youngjin Han, Hyangkyoung Kim, Tae-Won Kwon and Yong-Pil Cho

    Citation: Cardiovascular Diabetology 2017 16:74

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  44. Content type: Review

    Mechanisms underlying the pathogenesis of ischemia/reperfusion injury are particularly complex, multifactorial and highly interconnected. A complex and entangled interaction is also emerging between platelet f...

    Authors: Isabella Russo, Claudia Penna, Tiziana Musso, Jasmin Popara, Giuseppe Alloatti, Franco Cavalot and Pasquale Pagliaro

    Citation: Cardiovascular Diabetology 2017 16:71

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  45. Content type: Study protocol

    Type 2 diabetes mellitus (T2DM) is often associated with mixed dyslipidaemia, where non-high-density lipoprotein cholesterol (non-HDL-C) levels may more closely align with cardiovascular risk than low-density ...

    Authors: Dirk Müller-Wieland, Lawrence A. Leiter, Bertrand Cariou, Alexia Letierce, Helen M. Colhoun, Stefano Del Prato, Robert R. Henry, Francisco J. Tinahones, Lisa Aurand, Jaman Maroni, Kausik K. Ray and Maja Bujas-Bobanovic

    Citation: Cardiovascular Diabetology 2017 16:70

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  46. Content type: Original investigation

    Patients with type 2 diabetes present with an accelerated atherosclerotic process. Animal evidence indicates that dipeptidyl peptidase-4 inhibitors (gliptins) have anti-inflammatory and anti-atherosclerotic ef...

    Authors: Arwa Younis, Dana Eskenazi, Ronen Goldkorn, Jonathan Leor, Nili Naftali-Shani, Enrique Z. Fisman, Alexander Tenenbaum, Ilan Goldenberg and Robert Klempfner

    Citation: Cardiovascular Diabetology 2017 16:69

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  47. Content type: Original investigation

    Dyslipidaemia is a major contributor to the increased risk of cardiovascular disease (CVD) associated with type 2 diabetes (T2D). This study aimed to characterize the extent of lipid-lowering therapy use and i...

    Authors: Markolf Hanefeld, Louise Traylor, Ling Gao and Wolfgang Landgraf

    Citation: Cardiovascular Diabetology 2017 16:66

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  48. Content type: Original investigation

    Multiple bloodglucose-lowering agents have been linked to cardiovascular events. Preliminary studies showed improvement in left ventricular (LV) function during glucagon-like peptide-1 receptor agonist adminis...

    Authors: Weena J. Y. Chen, Michaela Diamant, Karin de Boer, Hendrik J. Harms, Lourens F. H. J. Robbers, Albert C. van Rossum, Mark H. H. Kramer, Adriaan A. Lammertsma and Paul Knaapen

    Citation: Cardiovascular Diabetology 2017 16:67

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