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  1. Acid–base imbalance has been reported to increase incidence of hypertension and diabetes. However, the association between diet-induced acid load and cardiovascular disease (CVD) risk in the general population...

    Authors: Eugene Han, Gyuri Kim, Namki Hong, Yong-ho Lee, Dong Woo Kim, Hyun Joon Shin, Byung-Wan Lee, Eun Seok Kang, In-Kyu Lee and Bong-Soo Cha
    Citation: Cardiovascular Diabetology 2016 15:122
    Content type: Original investigation Published on:

  2. Recent experimental studies have revealed that n-3 fatty acids, such as eicosapentaenoic acid (EPA) regulate postprandial insulin secretion, and correct postprandial glucose and lipid abnormalities. However, t...

    Authors: Takahiro Sawada, Hideo Tsubata, Naoko Hashimoto, Michinori Takabe, Taishi Miyata, Kosuke Aoki, Soichiro Yamashita, Shogo Oishi, Tsuyoshi Osue, Kiminobu Yokoi, Yasue Tsukishiro, Tetsuari Onishi, Akira Shimane, Yasuyo Taniguchi, Yoshinori Yasaka, Takeshi Ohara…
    Citation: Cardiovascular Diabetology 2016 15:121
    Content type: Original Investigation Published on:

  3. High fat diet (HFD) induces insulin resistance in various tissues, including the vasculature. HFD also increases plasma levels of TNF-α, a cytokine that contributes to insulin resistance and vascular dysfuncti...

    Authors: Rafael Menezes da Costa, Karla Bianca Neves, Fabíola Leslie Mestriner, Paulo Louzada-Junior, Thiago Bruder-Nascimento and Rita C. Tostes
    Citation: Cardiovascular Diabetology 2016 15:119
    Content type: Original investigation Published on:

  4. We intended to analyse the associations between blood glucose (BG) level and clinical outcomes of in-hospital cardiac arrest (IHCA).

    Authors: Chih-Hung Wang, Chien-Hua Huang, Wei-Tien Chang, Min-Shan Tsai, Ping-Hsun Yu, Yen-Wen Wu and Wen-Jone Chen
    Citation: Cardiovascular Diabetology 2016 15:118
    Content type: Original investigation Published on:

  5. Chemokines are critical components in pathology. The roles of chemokine CC motif ligand 4 (CCL4) and its receptor are associated with diabetes mellitus (DM) and atherosclerosis cardiovascular diseases. However...

    Authors: Ting-Ting Chang and Jaw-Wen Chen
    Citation: Cardiovascular Diabetology 2016 15:117
    Content type: Review Published on:

  6. An intergenic locus on chromosome 1 (lead SNP rs10911021) was previously associated with coronary heart disease (CHD) in type 2 diabetes (T2D). Using data from the UCLEB consortium we investigated the relation...

    Authors: Katherine E. Beaney, Jackie A. Cooper, Stela McLachlan, S. Goya Wannamethee, Barbara J. Jefferis, Peter Whincup, Yoav Ben-Shlomo, Jacqueline F. Price, Meena Kumari, Andrew Wong, Ken Ong, Rebecca Hardy, Diana Kuh, Mika Kivimaki, Antti J. Kangas, Pasi Soininen…
    Citation: Cardiovascular Diabetology 2016 15:115
    Content type: Original investigation Published on:

  7. Chronic stress is associated with increased risk of glucose intolerance and cardiovascular diseases, albeit through undefined mechanisms. With the aim of gaining insights into the latter, this study examined t...

    Authors: Vitor H. Pereira, Fernanda Marques, Vânia Lages, Filipa G. Pereira, Alexandre Patchev, Osborne F. X. Almeida, Joana Almeida-Palha, Nuno Sousa and João J. Cerqueira
    Citation: Cardiovascular Diabetology 2016 15:114
    Content type: Original investigation Published on:

  8. Despite the known risk of diabetes-induced cardiac fibrosis, less is known about whether diabetes causes an altered cardiac phenotype independent of coronary atherosclerosis. Peroxisome proliferator-activated ...

    Authors: Wei-Ting Chang, Juei-Tang Cheng and Zhih-Cherng Chen
    Citation: Cardiovascular Diabetology 2016 15:113
    Content type: Original investigation Published on:

  9. There are conflicting results for relationships between serum vitamin D levels and metabolic diseases. The aim of this study was to investigate whether serum vitamin D levels were associated with various metab...

    Authors: Ki-Chul Sung, Yoosoo Chang, Seungho Ryu and Hye-Kyung Chung
    Citation: Cardiovascular Diabetology 2016 15:112
    Content type: Original investigation Published on:

  10. Diabetic patients suffer from a high rate of cardiovascular events and such risk increases with HbA1c. However, lowering HbA1c does not appear to yield the same benefit on macrovascular endpoints, as observed ...

    Authors: Angelo Avogaro, Gian Paolo Fadini, Giorgio Sesti, Enzo Bonora and Stefano Del Prato
    Citation: Cardiovascular Diabetology 2016 15:111
    Content type: Review Published on:

  11. There is a spectacular rise in the global prevalence of type 2 diabetes mellitus (T2DM) due to the worldwide obesity epidemic. However, a significant proportion of T2DM patients are non-obese and they also hav...

    Authors: Márta Sárközy, Gergő Szűcs, Veronika Fekete, Márton Pipicz, Katalin Éder, Renáta Gáspár, Andrea Sója, Judit Pipis, Péter Ferdinandy, Csaba Csonka and Tamás Csont
    Citation: Cardiovascular Diabetology 2016 15:110
    Content type: Original investigation Published on:

  12. Complications of diabetes mellitus (DM) are related not only to elevated plasma glucose, but also plasma glucose fluctuations. However, the specific mechanism underlying the role of plasma glucose fluctuation ...

    Authors: Na Wu, Haitao Shen, Henan Liu, Yanjun Wang, Yu Bai and Ping Han
    Citation: Cardiovascular Diabetology 2016 15:109
    Content type: Original investigation Published on:

  13. This study investigated the association between serum gamma-glutamyltransferase (GGT) level and subclinical atherosclerosis in patients with type 2 diabetes.

    Authors: Hye Eun Yoon, Eun Young Mo, Seok Joon Shin, Sung Dae Moon, Je Ho Han and Eun Sook Kim
    Citation: Cardiovascular Diabetology 2016 15:108
    Content type: Original investigation Published on:

  14. PCSK9 inhibition is a new powerful cholesterol-lowering strategy. Recently, it was reported that CETP inhibitors influence PCSK9 levels as an off-target effect. We explored the relationship between circulating...

    Authors: Josefa Girona, Daiana Ibarretxe, Nuria Plana, Sandra Guaita-Esteruelas, Nuria Amigo, Mercedes Heras and Luis Masana
    Citation: Cardiovascular Diabetology 2016 15:107
    Content type: Original investigation Published on:

  15. We try to analyse the effect of renal functions on death in CAD patients with different body compositions.

    Authors: Yong Peng, Hua Wang, Fei Chen, Fang-yang Huang, Tian-li Xia, Yan-biao Liao, Hua Chai, Peng-ju Wang, Zhi-liang Zuo, Wei Liu, Chen Zhang, Yi-jian Li, Yi-yue Gui, Mao Chen and De-jia Huang
    Citation: Cardiovascular Diabetology 2016 15:106
    Content type: Original investigation Published on:

  16. Patients with type 2 diabetes (T2D) and coronary artery disease (CAD) have increased risk of cardiac dysfunction. The diabetic heart is characterized by increased fatty acid oxidation and reduced glucose uptak...

    Authors: Preman Kumarathurai, Christian Anholm, Olav W. Nielsen, Ole P. Kristiansen, Jens Mølvig, Sten Madsbad, Steen B. Haugaard and Ahmad Sajadieh
    Citation: Cardiovascular Diabetology 2016 15:105
    Content type: Original investigation Published on:

  17. To investigate whether atherogenic dyslipidemia, a dyslipidemic profile combining elevated triglycerides and low high-density lipoprotein (HDL) cholesterol, is predictive of risk of silent myocardial ischemia ...

    Authors: Paul Valensi, Antoine Avignon, Ariane Sultan, Bernard Chanu, Minh Tuan Nguyen and Emmanuel Cosson
    Citation: Cardiovascular Diabetology 2016 15:104
    Content type: Original investigation Published on:

  18. Authors: Ana Lopez-de-Andrés, Isabel Jiménez-Trujillo, Rodrigo Jiménez-García, Valentín Hernández-Barrera, José Mª de Miguel-Yanes, Manuel Méndez-Bailón, Napoleón Perez-Farinos, Miguel Ángel Salinero-Fort and Pilar Carrasco-Garrido
    Citation: Cardiovascular Diabetology 2016 15:103
    Content type: Erratum Published on:

    The original article was published in Cardiovascular Diabetology 2015 14:48

  19. The prevalence of type 2 diabetes (T2DM) in younger adults is growing. Compared to the late onset T2DM, it is well recognized that the disease tends to behave more aggressively in the younger age group with ev...

    Authors: Z. Z. Htike, T. Yates, E. M. Brady, D. Webb, L. J. Gray, D. Swarbrick, G. P. McCann, K. Khunti and M. J. Davies
    Citation: Cardiovascular Diabetology 2016 15:102
    Content type: Study protocol Published on:

  20. Strict glycaemic control in patients with type 2 diabetes has proven to have microvascular benefits while the effects on CVD and mortality are less clear, especially in high risk patients. Whether strict glyca...

    Authors: Sophie H. Bots, Yolanda van der Graaf, Hendrik M. W. Nathoe, Gert Jan de Borst, Jaap L. Kappelle, Frank L. J. Visseren and Jan Westerink
    Citation: Cardiovascular Diabetology 2016 15:101
    Content type: Original investigation Published on:

  21. Deferred revascularisation based upon fractional flow reserve (FFR >0.80) is associated with a low incidence of target lesion failure (TLF). Whether deferred revascularisation is also as safe in diabetes melli...

    Authors: Mark W. Kennedy, Eliza Kaplan, Rik S. Hermanides, Enrico Fabris, Veemal Hemradj, Petra C. Koopmans, Jan-Hank E. Dambrink, A. T. Marcel Gosselink, Arnoud W. J. van‘t Hof, Jan Paul Ottervanger, Vincent Roolvink, Wouter S. Remkes, Aize van der Sluis, Harry Suryapranata and Elvin Kedhi
    Citation: Cardiovascular Diabetology 2016 15:100
    Content type: Original investigation Published on:

  22. Glucagon-like peptide-1 (7–36) amide (GLP-1) protects against stunning and cumulative left ventricular dysfunction in humans. The mechanism remains uncertain but GLP-1 may act by opening mitochondrial K-ATP ch...

    Authors: Joel P. Giblett, Richard G. Axell, Paul A. White, Sophie J. Clarke, Liam McCormick, Philip A. Read, Johannes Reinhold, Adam J. Brown, Michael O’Sullivan, Nick E. J. West, David P. Dutka and Stephen P. Hoole
    Citation: Cardiovascular Diabetology 2016 15:99
    Content type: Original investigation Published on:

  23. Diabetes mellitus (DM) is associated to the morphological and componential characteristics of atheromatous plaques. It has proven that plaque textures are related to plaque components and beneficial for athero...

    Authors: Xiao-Wei Huang, Yan-Ling Zhang, Long Meng, Ming Qian, Wei Zhou, Rong-Qin Zheng, Hai-Rong Zheng and Li–Li Niu
    Citation: Cardiovascular Diabetology 2016 15:98
    Content type: Original investigation Published on:

  24. Heart failure (HF) and diabetes (DM) are a lethal combination. The current armamentarium of anti-diabetic agents has been shown to be less efficacious and sometimes even harmful in diabetic patients with conco...

    Authors: Jagdeep S. S. Singh, Amir Fathi, Keeran Vickneson, Ify Mordi, Mohapradeep Mohan, J. Graeme Houston, Ewan R. Pearson, Allan D. Struthers and Chim C. Lang
    Citation: Cardiovascular Diabetology 2016 15:97
    Content type: Methodology Published on:

  25. The effects of insulin on cardiomyocytes, such as positive inotropic action and glucose uptake are well described. However, in vitro studies comparing long-acting insulin analogues with regard to cardiomyocyte...

    Authors: Thorsten Hartmann, Sabrina Overhagen, D. Margriet Ouwens, Silja Raschke, Paulus Wohlfart, Norbert Tennagels, Nina Wronkowitz and Jürgen Eckel
    Citation: Cardiovascular Diabetology 2016 15:96
    Content type: Original investigation Published on:

  27. Vascular stiffening, a risk factor for cardiovascular disease, is accelerated, particularly in women with obesity and type 2 diabetes. Preclinical evidence suggests that dipeptidylpeptidase-4 (DPP-4) inhibitor...

    Authors: Camila Manrique, Javad Habibi, Annayya R. Aroor, James R. Sowers, Guanghong Jia, Melvin R. Hayden, Mona Garro, Luis A. Martinez-Lemus, Francisco I. Ramirez-Perez, Thomas Klein, Gerald A. Meininger and Vincent G. DeMarco
    Citation: Cardiovascular Diabetology 2016 15:94
    Content type: Original investigation Published on:

  28. Obesity is associated with multiple adverse cardiovascular conditions and may increase the risk of ventricular tachyarrhythmias (VT/VF). There is limited data on the association between obesity and risk of VT/...

    Authors: Barbara Szepietowska, Bronislava Polonsky, Saadia Sherazi, Yitschak Biton, Valentina Kutyifa, Scott McNitt, Mehmet Aktas, Arthur J. Moss and Wojciech Zareba
    Citation: Cardiovascular Diabetology 2016 15:93
    Content type: Original investigation Published on:

  29. It is not clear how severe metabolic syndrome (MS) affects the development of coronary atherosclerosis.

    Authors: Lee Kyung Kim, Ji Won Yoon, Dong-Hwa Lee, Kyoung Min Kim, Sung Hee Choi, Kyong Soo Park, Hak Chul Jang, Min-Kyung Kim, Hyo Eun Park, Su-Yeon Choi and Soo Lim
    Citation: Cardiovascular Diabetology 2016 15:92
    Content type: Original investigation Published on:

  30. To evaluate the role of the autonomic nervous system (ANS) in the development of insulin resistance (IR) and assess the relationship between IR and activity of ANS using power spectrum analysis of heart rate v...

    Authors: Maria K. Svensson, Stina Lindmark, Urban Wiklund, Peter Rask, Marcus Karlsson, Jan Myrin, Joel Kullberg, Lars Johansson and Jan W. Eriksson
    Citation: Cardiovascular Diabetology 2016 15:91
    Content type: Original investigation Published on:

  31. Omentin-1, a novel adipocytokine mainly expressed in visceral adipose tissue, has been found to inhibit the inflammatory response and improve insulin resistance as well as other obesity-related disorders. This...

    Authors: Yu Du, Qingwei Ji, Lun Cai, Fangjiong Huang, Yongqiang Lai, Yue Liu, Jianbo Yu, Bo Han, Enjun Zhu, Jinwei Zhang, Yujie Zhou, Zhijian Wang and Yingxin Zhao
    Citation: Cardiovascular Diabetology 2016 15:90
    Content type: Original investigation Published on:

  32. Combination therapy with canagliflozin and insulin was investigated in a prescribed substudy of the canagliflozin Cardiovascular Assessment Study (CANVAS); however, it was not evaluated in Japanese patients wi...

    Authors: Nobuya Inagaki, Shin-ichi Harashima, Nobuko Maruyama, Yutaka Kawaguchi, Maki Goda and Hiroaki Iijima
    Citation: Cardiovascular Diabetology 2016 15:89
    Content type: Original investigation Published on:

  33. Endothelial dysfunction has been suggested as a possible causal link between hyperglycemia and microvascular complications in diabetes mellitus. The effect of metformin on endothelial progenitor cells (EPCs) i...

    Authors: Jia-Wen Yu, Ya-Ping Deng, Xue Han, Guo-Fei Ren, Jian Cai and Guo-Jun Jiang
    Citation: Cardiovascular Diabetology 2016 15:88
    Content type: Original investigation Published on:

  34. Xanthine oxidase inhibitors are anti-hyperuricemic drugs that decrease serum uric acid levels by inhibiting its synthesis. Xanthine oxidase is also recognized as a pivotal enzyme in the production of oxidative...

    Authors: Jun-ichi Oyama, Atsushi Tanaka, Yasunori Sato, Hirofumi Tomiyama, Masataka Sata, Tomoko Ishizu, Isao Taguchi, Takanori Kuroyanagi, Hiroki Teragawa, Nobukazu Ishizaka, Yumiko Kanzaki, Mitsuru Ohishi, Kazuo Eguchi, Yukihito Higashi, Hirotsugu Yamada, Koji Maemura…
    Citation: Cardiovascular Diabetology 2016 15:87
    Content type: Study protocol Published on:

  35. There is an increasing appreciation for a series of less traditional risk factors that should not be ignored when considering type 2 diabetes, obesity, hypertension, and cardiovascular disease. These include a...

    Authors: Craig L. Hanis, Susan Redline, Brian E. Cade, Graeme I. Bell, Nancy J. Cox, Jennifer E. Below, Eric L. Brown and David Aguilar
    Citation: Cardiovascular Diabetology 2016 15:86
    Content type: Original investigation Published on:

  37. To assess the 9-year changes of the incidence and characteristics of metabolic syndrome (MetS) in Chinese community under the background of dramatically changed environment.

    Authors: Boren Jiang, Bin Li, Yongbin Wang, Bing Han, Ningjian Wang, Qin Li, Weihong Yang, Guolan Huang, Jinhua Wang, Yi Chen, Yingchao Chen, Chunfang Zhu, Dongping Lin and Yingli Lu
    Citation: Cardiovascular Diabetology 2016 15:84
    Content type: Original investigation Published on:

  38. In patients with type 2 diabetes, the prognostic impact of an orthostatic rise in blood pressure is not known. Therefore, the aim of this study was to determine the prognostic implications of the diastolic ort...

    Authors: Magnus Wijkman, Toste Länne, Carl Johan Östgren and Fredrik H. Nystrom
    Citation: Cardiovascular Diabetology 2016 15:83
    Content type: Original investigation Published on:

  39. Hyperglycemia is acknowledged as a pro-inflammatory condition and a major cause of vascular damage. Nevertheless, we have previously described that high glucose only promotes inflammation in human vascular cel...

    Authors: Concepción Peiró, Tania Romacho, Verónica Azcutia, Laura Villalobos, Emilio Fernández, Juan P. Bolaños, Salvador Moncada and Carlos F. Sánchez-Ferrer
    Citation: Cardiovascular Diabetology 2016 15:82
    Content type: Original investigation Published on:

    The Erratum to this article has been published in Cardiovascular Diabetology 2017 16:25

  40. The risk for a first myocardial infarction (MI) in people with diabetes has been shown to be as high as the risk for a new MI in non-diabetic patients with a prior MI. Consequently, risk-reducing statin therap...

    Authors: Martin Bødtker Mortensen, Imra Kulenovic and Erling Falk
    Citation: Cardiovascular Diabetology 2016 15:81
    Content type: Original Investigation Published on:

  41. We have previously shown that a Palaeolithic diet consisting of the typical food groups that our ancestors ate during the Palaeolithic era, improves cardiovascular disease risk factors and glucose control comp...

    Authors: Maelán Fontes-Villalba, Staffan Lindeberg, Yvonne Granfeldt, Filip K. Knop, Ashfaque A. Memon, Pedro Carrera-Bastos, Óscar Picazo, Madhvi Chanrai, Jan Sunquist, Kristina Sundquist and Tommy Jönsson
    Citation: Cardiovascular Diabetology 2016 15:80
    Content type: Original investigation Published on:

  42. Several studies have revealed that glucose fluctuations provoke oxidative stress that leads to endothelial cell dysfunction, progression of coronary atherosclerosis, and plaque vulnerability. However, little i...

    Authors: Masaru Kuroda, Toshiro Shinke, Hiromasa Otake, Daisuke Sugiyama, Tomofumi Takaya, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Natsuko Tahara, Daiji Kashiwagi, Koji Kuroda, Yuto Shinkura, Yoshinori Nagasawa, Kazuhiko Sakaguchi, Yushi Hirota, Wataru Ogawa…
    Citation: Cardiovascular Diabetology 2016 15:79
    Content type: Original investigation Published on:

  43. To identify possible differences in cardiovascular (CV) risk among different insulin therapies, we performed pre-specified meta-analyses across the clinical program for basal insulin peglispro (BIL), in patien...

    Authors: Byron J. Hoogwerf, A. Michael Lincoff, Angel Rodriguez, Lei Chen and Yongming Qu
    Citation: Cardiovascular Diabetology 2016 15:78
    Content type: Original investigation Published on:

  44. Impaired vasoreactivity is often observed in subjects with metabolic syndrome, a condition that includes the presence of a specific cluster of risk factors for obesity and cardiovascular disease. However, hier...

    Authors: Michio Shimabukuro, Namio Higa, Hiroaki Masuzaki, Masataka Sata and Shinichiro Ueda
    Citation: Cardiovascular Diabetology 2016 15:77
    Content type: Original investigation Published on:

  45. The aim of the present study was to elucidate the effect of teneligliptin on oxidative stress and endothelial function in Japanese patients with type 2 diabetes and chronic kidney disease (CKD).

    Authors: Masaaki Sagara, Kunihiro Suzuki, Chie Aoki, Seiichi Tanaka, Isao Taguchi, Teruo Inoue and Yoshimasa Aso
    Citation: Cardiovascular Diabetology 2016 15:76
    Content type: Original investigation Published on:

  46. Type-2 diabetics have an increased risk of cardiomyopathy, and heart failure is a major cause of death among these patients. Growing evidence indicates that proinflammatory cytokines may induce the development...

    Authors: Sevil Korkmaz-Icöz, Samer Al Said, Tamás Radovits, Shiliang Li, Maik Brune, Péter Hegedűs, Ayhan Atmanli, Mihály Ruppert, Paige Brlecic, Lorenz Heyne Lehmann, Bernd Lahrmann, Niels Grabe, Yutaka Yoshikawa, Hiroyuki Yasui, Patrick Most, Matthias Karck…
    Citation: Cardiovascular Diabetology 2016 15:75
    Content type: Original investigation Published on:

  47. Previous studies have reported an increasing prevalence of metabolic abnormalities in immigrants who moved from low-cardiovascular-risk regions to Western countries, but little is known about time trends follo...

    Authors: Yonatan Reuven, Jacob Dreiher and Pesach Shvartzman
    Citation: Cardiovascular Diabetology 2016 15:74
    Content type: Original investigation Published on:

  48. Low birth weight is associated with increased rates of obesity, insulin resistance and type 2 diabetes, but the precise mechanisms for this association remain unclear. We aimed to assess the relationships betw...

    Authors: François R. Jornayvaz, Peter Vollenweider, Murielle Bochud, Vincent Mooser, Gérard Waeber and Pedro Marques-Vidal
    Citation: Cardiovascular Diabetology 2016 15:73
    Content type: Original investigation Published on:

  49. To analyze whether medical care is in accordance with guidelines for secondary prevention of myocardial infarction (MI), or stroke in patients with type 2 diabetes from Germany and Austria.

    Authors: Barbara Bohn, Christof Schöfl, Vincent Zimmer, Michael Hummel, Nikolai Heise, Erhard Siegel, Wolfram Karges, Michaela Riedl and Reinhard W. Holl
    Citation: Cardiovascular Diabetology 2016 15:72
    Content type: Original investigation Published on:

  50. Intracellular antioxidant response to high glucose is mediated by Cu/Mn-superoxide dismutases (SOD-1/SOD-2), catalase (CAT) and glutathione peroxidases (GPx), particularly glutathione peroxidase-1 (GPx-1). Alt...

    Authors: Lucia La Sala, Monica Cattaneo, Valeria De Nigris, Gemma Pujadas, Roberto Testa, Anna R. Bonfigli, Stefano Genovese and Antonio Ceriello
    Citation: Cardiovascular Diabetology 2016 15:71
    Content type: Original investigation Published on:
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Cardiovascular Diabetology

ISSN: 1475-2840