Lala A, Johnson KW, Januzzi JL, et al. Prevalence and impact of myocardial injury in patients hospitalized with COVID-19 infection. J Am Coll Cardiol. 2020;76:533–46.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shi S, Qin M, Cai Y, Liu T, et al. Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019. Eur Heart J. 2020;4:2070–9.
Article
Google Scholar
Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O. Potential effects of coronaviruses on the cardiovascular system: a review. JAMA Cardiol. 2020;5:831–40.
Article
PubMed
Google Scholar
Ceriello A, Standl E, Catrinoiu D, Itzhak B, Lalic NM, Rahelic D, Schnell O, Škrha J, Valensi P. Issues of cardiovascular risk management in people with diabetes in the COVID-19 era. Diabetes Care. 2020.
De Luca G, Cercek M, Jensen LO, et al. Impact of COVID-19 pandemic and diabetes on mechanical reperfusion in patients with STEMI: insights from the ISACS STEMI COVID 19 registry. Cardiovasc Diabetol. 2020;19:215. https://doi.org/10.1186/s12933-020-01196-0.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sheshah E, Sabico S, Albakr RM, Sultan AA, Alghamdi KS, Madani KA, Alotair HA, Al-Daghri NM. Prevalence of diabetes, management and outcomes among Covid-19 adult patients admitted in a specialized tertiary hospital in Riyadh, Saudi Arabia. Diabetes Res Clin Pract. 2021;172:108538. https://doi.org/10.1016/j.diabres.2020.108538.
Article
CAS
PubMed
Google Scholar
Maddaloni E, D’Onofrio L, Alessandri F, Mignogna C, Leto G, Pascarella G, Mezzaroma I, Lichtner M, Pozzilli P, Agrò FE, Rocco M, Pugliese F, Lenzi A, Holman RR, Mastroianni CM, Buzzetti R, CoViDiab Study Group. Cardiometabolic multimorbidity is associated with a worse Covid-19 prognosis than individual cardiometabolic risk factors: a multicentre retrospective study (CoViDiab II). Cardiovasc Diabetol. 2020;19(1):164. https://doi.org/10.1186/s12933-020-01140-2.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pretorius E, Venter C, Laubscher GJ et al. Prevalence of readily detected amyloid blood clots in ‘unclotted’ Type 2 diabetes mellitus and COVID-19 plasma: a preliminary report. Cardiovasc Diabetol 2020;193. https://doi.org/10.1186/s12933-020-01165-7.
Longo M, Caruso P, Maiorino MI, Bellastella G, Giugliano D, Esposito K. Treating type 2 diabetes in COVID-19 patients: the potential benefits of injective therapies. Cardiovasc Diabetol. 2020;19(1):115. https://doi.org/10.1186/s12933-020-01090-9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ceriello A, Standl E, Catrinoiu D, Itzhak B, Lalic NM, Rahelic D, Schnell O, Škrha J, Valensi P. “Diabetes and Cardiovascular Disease (D&CVD)” Study Group of the European Association for the Study of Diabetes (EASD). Issues for the management of people with diabetes and COVID-19 in ICU. Cardiovasc Diabetol. 2020;19(1):114. https://doi.org/10.1186/s12933-020-01089-2.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ren H, Yang Y, Wang F, Yan Y, Shi X, Dong K, Yu X, Zhang S. Association of the insulin resistance marker TyG index with the severity and mortality of COVID-19. Cardiovasc Diabetol. 2020;19(1):58. https://doi.org/10.1186/s12933-020-01035-2.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sardu C, Gargiulo G, Esposito G, Paolisso G, Marfella R. Impact of diabetes mellitus on clinical outcomes in patients affected by Covid-19. Cardiovasc Diabetol. 2020;19(1):76. https://doi.org/10.1186/s12933-020-01047-y.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Xia J, Yu T, Zhang X, Zhang L. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507–13. https://doi.org/10.1016/S0140-6736(20)30211-7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Ericksen S, Schiergens TS, Herrler G, Wu N-W, Nitsche A, Müller MA, Drosten C, Pöhlmann S. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271-280.e8. https://doi.org/10.1016/j.cell.2020.02.052.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shajahan, A, Archer-Hartmann, S, Supekar, NT, Gleinich, AS, Heiss, C, Azadi, P. Comprehensive characterization of N- and O-glycosylation of SARS-CoV-2 human receptor angiotensin converting enzyme 2. Glycobiology. 2020;cwaa101. https://doi.org/10.1093/glycob/cwaa101.
Guo L, Bi W, Wang X, Xu W, Yan R, Zhang Y, Zhao K, Li Y, Zhang M, Cai X, Jiang S, Xie Y, Zhou Q, Lu L, Dang B. Engineered trimeric ACE2 binds viral spike protein and locks it in “Three-up” conformation to potently inhibit SARS-CoV-2 infection. Cell Res. 2021;31(1):98–100. https://doi.org/10.1038/s41422-020-00438-w.
Article
CAS
PubMed
Google Scholar
Zhao P, Praissman JL, Grant OC, Cai Y, Xiao T, Rosenbalm KE, Aoki K, Kellman BP, Bridger R, Barouch DH, Brindley MA, Lewis NE, Tiemeyer M, Chen B, Woods RJ, Wellis L. Virus–receptor interactions of glycosylated SARS-CoV-2 spike and human ACE2 receptor. Cell Host Microbe. 2020;28(4):586–6016. https://doi.org/10.1016/j.chom.2020.08.004.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xiao T, Lu J, Zhang J, Johnson RI, McKay LGA, Storm N, Lavine CL, Peng H, Cai Y, Rits-Volloch S, Lu S, Quinlan BD, Farzan M, Seaman MS, Griffiths A, Chen B. A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent. Nat Struct Mol Biol. 2021. https://doi.org/10.1038/s41594-020-00549-3.
Article
PubMed
PubMed Central
Google Scholar
Chen Y, Liu Q, Guo D. Emerging coronaviruses: genome structure, replication, and pathogenesis. J Med Virol. 2020;92:418–23. https://doi.org/10.1002/jmv.25681.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, Gong W, Liu X, Liang J, Zhao Q, Huang H, Yang B, Huang C. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol. 2020;5:802–10.
Article
PubMed
PubMed Central
Google Scholar
Bulfamante GP, Perrucci GL, Falleni M, Sommariva E, Tosi D, Martinelli C, Songia P, Poggio P, Carugo S, Pompilio G. Evidence of SARS-CoV-2 transcriptional activity in cardiomyocytes of COVID-19 patients without clinical signs of cardiac involvement. Biomedicines. 2020;8(12):626. https://doi.org/10.3390/biomedicines8120626.
Article
CAS
PubMed Central
Google Scholar
Letarov AV, Babenko VV, Kulikov EE. Free SARS-CoV-2 spike protein S1 particles may play a role in the pathogenesis of COVID-19 infection. Biochemistry (Mosc). 2021;86(3):257–61. https://doi.org/10.1134/S0006297921030032.
Article
CAS
Google Scholar
Brufsky A. Hyperglycemia, hydroxychloroquine, and the COVID-19 pandemic. J Med Virol. 2020;92:770–5. https://doi.org/10.1002/jmv.25887.
Article
CAS
PubMed
Google Scholar
Forbes M, Cooper ME. Mechanisms of diabetic complications. Physiol Rev. 2013;93:137–88.
Article
CAS
PubMed
Google Scholar
Geuijen KPM, Oppers-Tiemissen C, Egging DF, Simons PJ, Boon L, Schasfoort RBM, Eppink MHM. Rapid screening of IgG quality attributes-effects on Fc receptor binding. FEBS Open Bio. 2017;7(10):1557–74. https://doi.org/10.1002/2211-5463.12283.
Article
CAS
PubMed
PubMed Central
Google Scholar
Marfella R, Amarelli C, Cacciatore F, et al. Lipid accumulation in hearts transplanted from nondiabetic donors to diabetic recipients. J Am Coll Cardiol. 2020;75:1249–62.
Article
CAS
PubMed
Google Scholar
Esposito S, Maiello C, Renzulli A, et al. Determinants and prognostic value of ischemic necrosis in early biopsies following heart transplant. Heart Vessels. 2000;15:167–71.
Article
CAS
PubMed
Google Scholar
Cotrufo M, De Santo LS, Della Corte A, et al. Acute hemodynamic and functional effects of surgical ventricular restoration and heart transplantation in patients with ischemic dilated cardiomyopathy. J Thorac Cardiovasc Surg. 2008;135:1054–60.
Article
PubMed
Google Scholar
American Diabetes Association. Classification and diagnosis of diabetes: standards of medical care in diabetes-2018. Diabetes Care. 2018;41(Suppl 1):S13–27.
Article
Google Scholar
Galiè N, Humbert M, Vachiery JL, ESC Scientific Document Group. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur Heart J. 2016;37:67–119.
Article
PubMed
Google Scholar
Corman VM, Landt O, Kaiser M, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill. 2020;25:1804–6.
Google Scholar
Nicin L, Abplanalp WT, Mellentin H, et al. Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts. Eur Heart J. 2020;41:1804–6.
Article
CAS
PubMed
Google Scholar
Basso C, Leone O, Rizzo S, et al. Pathological features of COVID-19-associated myocardial injury: a multicentre cardiovascular pathology study. Eur Heart J. 2020;41:3827–35.
Article
CAS
PubMed
Google Scholar
Lindner D, Fitzek A, Bräuninger H, et al. Association of cardiac infection with SARS-CoV-2 in confirmed COVID-19 autopsy cases. JAMA Cardiol. 2021;5:1281–5.
Article
Google Scholar
Bojkova D, Wagner JUG, Shumliakivska M, et al. SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes. Cardiovasc Res. 2020;116:2207–15.
Article
CAS
PubMed
Google Scholar
Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science. 2020;6485:1444–8. https://doi.org/10.1126/science.abb2762.
Article
Google Scholar
Bernardi A, Huang Y, Harris B, Xiong Y, Nandi S, McDonald KA, Faller R. Development and simulation of fully glycosylated molecular models of ACE2-Fc fusion proteins and their interaction with the SARS-CoV-2 spike protein binding domain. PLoS ONE. 2020;8:e0237295. https://doi.org/10.1371/journal.pone.0237295.
Article
CAS
Google Scholar
Lan J, Ge J, Yu J, Shan S, Zhou H, Fan S, Zhang Q, Shi X, Wang Q, Zhang L, Wang X. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature. 2020;581:215–20. https://doi.org/10.1038/s41586-020-2180-5.
Article
CAS
PubMed
Google Scholar
Chen L, Li X, Chen M, Feng Yi, Xiong C. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Cardiovasc Res. 2020;116(6):1097–100. https://doi.org/10.1093/cvr/cvaa078.
Article
CAS
PubMed
Google Scholar
Goh SY, Cooper ME. Clinical review: the role of advanced glycation end products in progression and complications of diabetes. J Clin Endocrinol Metab. 2008;4:1143–52. https://doi.org/10.1210/jc.2007-1817.
Article
CAS
Google Scholar
Ravaioli S, Tebaldi M, Fonzi E, Angeli D, Mazza M, Nicolini F, Lucchesi A, Fanini F, Pirini F, Tumedei MM, Cerchione C, Viale P, Sambri V, Martinelli G, Bravaccini S. ACE2 and TMPRSS2 potential involvement in genetic susceptibility to SARS-COV-2 in cancer patients. Cell Transplant. 2020;29:96368–7209.
Article
Google Scholar
Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA. Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. Proc Natl Acad Sci USA. 2020;117(45):28046–55.
Article
CAS
PubMed
PubMed Central
Google Scholar
Marfella R, Paolisso P, Sardu C, Bergamaschi L, D’Angelo EC, Barbieri M, Rizzo MR, Messina V, Maggi P, Coppola N, Pizzi C, Biffi M, Viale P, Galié N, Paolisso G. Negative impact of hyperglycaemia on tocilizumab therapy in Covid-19 patients. Diabetes Metab. 2020;46(5):403–5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Paolisso P, Bergamaschi L, D’Angelo EC, Donati F, Giannella M, Tedeschi S, Pascale R, Bartoletti M, Tesini G, Biffi M, Cosmi B, Pizzi C, Viale P, Galié N. Preliminary experience with low molecular weight heparin strategy in COVID-19 patients. Front Pharmacol. 2020;6(11):1124. https://doi.org/10.3389/fphar.2020.01124.PMID:32848743;PMCID:PMC7424043.
Article
Google Scholar
Bergamaschi L, D’Angelo EC, Paolisso P, Toniolo S, Fabrizio M, Angeli F, Donati F, Magnani I, Rinaldi A, Bartoli L, Chiti C, Biffi M, Pizzi C, Viale P, Galié N. The value of ECG changes in risk stratification of COVID-19 patients. Ann Noninvasive Electrocardiol. 2021;29:e12815. https://doi.org/10.1111/anec.12815.
Article
Google Scholar
Chung MK, Zidar DA, Bristow MR, Cameron SJ, Chan T, Harding CV 3rd, Kwon DH, Singh T, Tilton JC, Tsai EJ, Tucker NR, Barnard J, Loscalzo J. COVID-19 and cardiovascular disease: from bench to bedside. Circ Res. 2021;128(8):1214–36. https://doi.org/10.1161/CIRCRESAHA.121.317997.
Article
CAS
PubMed
PubMed Central
Google Scholar