Articles

Serum alkaline phosphatase levels and the risk of new-onset diabetes in hypertensive adults

The association between alkaline phosphatase (ALP) and incident diabetes remains uncertain. Our study aimed to investigate the prospective relation of serum ALP with the risk of new-onset diabetes, and explore...

Authors: Yuanyuan Zhang, Chun Zhou, Jianping Li, Yan Zhang, Di Xie, Min Liang, Binyan Wang, Yun Song, Xiaobin Wang, Yong Huo, Fan Fan Hou, Xiping Xu and Xianhui Qin

Worldwide inertia to the use of cardiorenal protective glucose-lowering drugs (SGLT2i and GLP-1 RA) in high-risk patients with type 2 diabetes

The disclosure of proven cardiorenal benefits with certain antidiabetic agents was supposed to herald a new era in the management of type 2 diabetes (T2D), especially for the many patients with T2D who are at ...

Authors: Guntram Schernthaner, Naim Shehadeh, Alexander S. Ametov, Anna V. Bazarova, Fahim Ebrahimi, Peter Fasching, Andrej Janež, Péter Kempler, Ilze Konrāde, Nebojša M. Lalić, Boris Mankovsky, Emil Martinka, Dario Rahelić, Cristian Serafinceanu, Jan Škrha, Tsvetalina Tankova…

Distinct non-ischemic myocardial late gadolinium enhancement lesions in patients with type 2 diabetes

Cardiovascular magnetic resonance imaging (CMR) have described localised non-ischemic late gadolinium enhancement (LGE) lesions of prognostic importance in various non-ischemic cardiomyopathies. Ischemic LGE l...

Authors: Annemie Stege Bojer, Martin Heyn Sørensen, Niels Vejlstrup, Jens P. Goetze, Peter Gæde and Per Lav Madsen

Prognostic impact of admission high-sensitivity C-reactive protein in acute myocardial infarction patients with and without diabetes mellitus

High-sensitivity C-reactive protein (hs-CRP) elevation frequently occurs in acute myocardial infarction (AMI) and is associated with adverse outcomes. Since diabetes mellitus (DM) is characterized by an underl...

Authors: Claudia Lucci, Nicola Cosentino, Stefano Genovese, Jeness Campodonico, Valentina Milazzo, Monica De Metrio, Maurizio Rondinelli, Daniela Riggio, Maria Luisa Biondi, Mara Rubino, Katia Celentano, Alice Bonomi, Nicolò Capra, Fabrizio Veglia, Piergiuseppe Agostoni, Antonio L. Bartorelli…

Global trend of diabetes mortality attributed to vascular complications, 2000–2016

The global epidemic of diabetes mellitus continues to grow and affects developed and developing countries alike. Intensive glycemic control is thought to modify the risks for vascular complications, hence the ...

Authors: Wei Ling, Yi Huang, Yan-Mei Huang, Rong-Rong Fan, Yi Sui and Hai-Lu Zhao

Blood pressure levels and cardiovascular risk according to age in patients with diabetes mellitus: a nationwide population-based cohort study

Little is known about age-specific target blood pressure (BP) in hypertensive patients with diabetes mellitus (DM). The aim of this study was to determine the BP level at the lowest cardiovascular risk of hype...

Authors: Hack-Lyoung Kim, Hyue Mee Kim, Chang Hee Kwon, Jeong-Hun Shin, Mi-Hyang Jung, Chan Joo Lee, Dae-Hee Kim, Woo-Hyeun Kim, Si-Hyuck Kang, Ju-Hee Lee, In Jeong Cho, Iksung Cho, Jun Hyeok Lee, Dae Ryong Kang, Hae-Young Lee, Wook-Jin Chung…

MR-proANP and incident cardiovascular disease in patients with type 2 diabetes with and without heart failure with preserved ejection fraction

Mid-regional pro-atrial natriuretic peptide (MR-proANP) is a useful biomarker in outpatients with type 2 diabetes (T2D) to diagnose heart failure (HF). Elevated B-type natriuretic peptides are included in the ...

Authors: Jesper Jensen, Morten Schou, Caroline Kistorp, Jens Faber, Tine W. Hansen, Magnus T. Jensen, Henrik U. Andersen, Peter Rossing, Tina Vilsbøll and Peter G. Jørgensen

Ticagrelor monotherapy in patients with concomitant diabetes mellitus and chronic kidney disease: a post hoc analysis of the GLOBAL LEADERS trial

Patients with both diabetes mellitus (DM) and chronic kidney disease (CKD) are a subpopulation characterized by ultrahigh ischemic and bleeding risk after percutaneous coronary intervention. There are limited ...

Authors: Chao Gao, Mariusz Tomaniak, Kuniaki Takahashi, Hideyuki Kawashima, Rutao Wang, Hironori Hara, Masafumi Ono, Gilles Montalescot, Scot Garg, Michael Haude, Ton Slagboom, Pascal Vranckx, Marco Valgimigli, Stephan Windecker, Robert-Jan van Geuns, Christian Hamm…

Associations of cardiac stress biomarkers with incident type 2 diabetes and changes in glucose metabolism: KORA F4/FF4 study

High N-terminal pro-brain-type natriuretic peptide levels have been associated with a lower risk of type 2 diabetes mellitus (T2D). However, less is known about other cardiac stress biomarkers in this context....

Authors: Chaterina Sujana, Jochen Seissler, Jens Jordan, Wolfgang Rathmann, Wolfgang Koenig, Michael Roden, Ulrich Mansmann, Christian Herder, Annette Peters, Barbara Thorand and Cornelia Then

Incidence of idiopathic cardiomyopathy in patients with type 2 diabetes in Taiwan: age, sex, and urbanization status-stratified analysis

The epidemiology of diabetes and idiopathic cardiomyopathy have limited data. We investigated the overall and the age-, sex-, and urbanization-specific incidence and relative hazard of idiopathic cardiomyopath...

Authors: Hua-Fen Chen, Ya-Hui Chang, Hsien-Jung Lo, Muhammad Atoillah Isfandiari, Santi Martini, Wen-Hsuan Hou and Chung-Yi Li

Empagliflozin reduced long-term HbA1c variability and cardiovascular death: insights from the EMPA-REG OUTCOME trial

Glucose variability has been associated with cardiovascular outcomes in type 2 diabetes, however, the interplay between glucose variability, empagliflozin and cardiovascular death has not been explored. In the...

Authors: Antonio Ceriello, Anne Pernille Ofstad, Isabella Zwiener, Stefan Kaspers, Jyothis George and Antonio Nicolucci

Blood pressure and mortality in patients with type 2 diabetes and a recent coronary event in the ELIXA trial

The relationship between blood pressure and mortality in type 2 diabetes (T2DM) is controversial, with concern for increased risk associated with excessively lowered blood pressure.

Authors: Magnus O. Wijkman, Brian Claggett, Rafael Diaz, Hertzel C. Gerstein, Lars Køber, Eldrin Lewis, Aldo P. Maggioni, Emil Wolsk, David Aguilar, Rhonda Bentley-Lewis, John J. McMurray, Jeffrey Probstfield, Matthew Riddle, Jean-Claude Tardif, Scott D. Solomon and Marc A. Pfeffer

Cardiovascular risks and bleeding with non-vitamin K antagonist oral anticoagulant versus warfarin in patients with type 2 diabetes: a tapered matching cohort study

We compared the risk of bleeding and cardiovascular disease (CVD) events between non-vitamin K antagonist oral anticoagulant (NOAC) and warfarin in people with type 2 diabetes (T2DM).

Authors: Dahai Yu, Zhanzheng Zhao and David Simmons

Use of the ankle-brachial index combined with the percentage of mean arterial pressure at the ankle to improve prediction of all-cause mortality in type 2 diabetes mellitus: an observational study

Peripheral artery disease (PAD) in the lower extremities is a common complication of type 2 diabetes and has been shown to be associated with mortality. The ankle-brachial index (ABI) is a simple noninvasive m...

Authors: Yu-Hsuan Li, Wayne Huey-Herng Sheu and I-Te Lee

Comparative effectiveness of dulaglutide versus liraglutide in Asian type 2 diabetes patients: a multi-institutional cohort study and meta-analysis

Head-to-head comparison of clinical effectiveness between dulaglutide and liraglutide in Asia is limited. This study was aimed to assess the real-world comparative effectiveness of dulaglutide versus liraglutide.

Authors: Kai-Cheng Chang, Shih-Chieh Shao, Shihchen Kuo, Chen-Yi Yang, Hui-Yu Chen, Yuk-Ying Chan and Huang-Tz Ou

High glycated albumin is an independent predictor of low response to clopidogrel in ACS patients: a cross-sectional study

Glycated albumin (GA) is a marker of short-term glycemic control and is strongly associated with the occurrence of diabetes. Previous studies have shown an association between GA and the effect of clopidogrel ...

Authors: Xiliang Zhao, Quan Li, Chenchen Tu, Yong Zeng and Yicong Ye

Association between omentin-1 and major cardiovascular events after lower extremity endovascular revascularization in diabetic patients: a prospective cohort study

Cardiovascular complications represent the major cause of morbidity and mortality of type 2 diabetes mellitus (T2DM) patients. In particular, peripheral artery disease (PAD) represents a frequent T2DM vascular...

Authors: Federico Biscetti, Elisabetta Nardella, Maria Margherita Rando, Andrea Leonardo Cecchini, Flavia Angelini, Alessandro Cina, Roberto Iezzi, Marco Filipponi, Angelo Santoliquido, Dario Pitocco, Raffaele Landolfi and Andrea Flex

Impact of combined training with different exercise intensities on inflammatory and lipid markers in type 2 diabetes: a secondary analysis from a 1-year randomized controlled trial

Exercise is a well-accepted strategy to improve lipid and inflammatory profile in individuals with type 2 diabetes (T2DM). However, the exercise intensity having the most benefits on lipids and inflammatory ma...

Authors: João P. Magalhães, Diana A. Santos, Inês R. Correia, Megan Hetherington-Rauth, Rogério Ribeiro, João F. Raposo, Andreia Matos, Manuel D. Bicho and Luís B. Sardinha

Adolescent BMI and early-onset type 2 diabetes among Ethiopian immigrants and their descendants: a nationwide study

We assessed in a nationwide cohort the association between adolescent BMI and early-onset (< 40 years) type 2 diabetes among Israelis of Ethiopian origin.

Authors: Maya Simchoni, Uri Hamiel, Orit Pinhas-Hamiel, Inbar Zucker, Tali Cukierman-Yaffe, Miri Lutski, Estela Derazne, Zivan Beer, Doron Behar, Lital Keinan-Boker, Ofri Mosenzon, Dorit Tzur, Arnon Afek, Amir Tirosh, Itamar Raz and Gilad Twig

Association of circulating PCSK9 concentration with cardiovascular metabolic markers and outcomes in stable coronary artery disease patients with or without diabetes: a prospective, observational cohort study

Whether plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels is a predictor for cardiovascular outcomes has currently been controversial. No data is currently available regarding the relation of...

Authors: Jia Peng, Ming-Ming Liu, Jing-Lu Jin, Ye-Xuan Cao, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Qian Dong, Jing Sun, Rui-Xia Xu and Jian-Jun Li

Evaluation of cardiovascular risk in adults with type 1 diabetes: poor concordance between the 2019 ESC risk classification and 10-year cardiovascular risk prediction according to the Steno Type 1 Risk Engine

Patients with type 1 diabetes (T1D) have higher mortality risk compared to the general population; this is largely due to increased rates of cardiovascular disease (CVD). As accurate CVD risk stratification is...

Authors: Nicola Tecce, Maria Masulli, Roberta Lupoli, Giuseppe Della Pepa, Lutgarda Bozzetto, Luisa Palmisano, Angela Albarosa Rivellese, Gabriele Riccardi and Brunella Capaldo

Everolimus-eluting bioresorbable scaffolds and metallic stents in diabetic patients: a patient-level pooled analysis of the prospective ABSORB DM Benelux Study, TWENTE and DUTCH PEERS

Several studies compared everolimus-eluting bioresorbable scaffolds (EE-BRS) with everolimus-eluting stents (EES), but only few assessed these devices in patients with diabetes mellitus.

Authors: T. M. Hommels, R. S. Hermanides, B. Berta, E. Fabris, G. De Luca, E. H. Ploumen, C. von Birgelen and E. Kedhi

Cardiometabolic multimorbidity is associated with a worse Covid-19 prognosis than individual cardiometabolic risk factors: a multicentre retrospective study (CoViDiab II)

Cardiometabolic disorders may worsen Covid-19 outcomes. We investigated features and Covid-19 outcomes for patients with or without diabetes, and with or without cardiometabolic multimorbidity.

Authors: Ernesto Maddaloni, Luca D’Onofrio, Francesco Alessandri, Carmen Mignogna, Gaetano Leto, Giuseppe Pascarella, Ivano Mezzaroma, Miriam Lichtner, Paolo Pozzilli, Felice Eugenio Agrò, Monica Rocco, Francesco Pugliese, Andrea Lenzi, Rury R. Holman, Claudio Maria Mastroianni and Raffaella Buzzetti

Left atrial strain and diastolic function abnormalities in obese and type 2 diabetic adolescents and young adults

Adults with obesity and type 2 diabetes mellitus (T2DM) related to obesity are at increased risk of heart failure with preserved ejection fraction (HFpEF). Whether left ventricular (LV) diastolic function abno...

Authors: Jeremy M. Steele, Elaine M. Urbina, Wojciech M. Mazur, Philip R. Khoury, Sherif F. Nagueh, Justin T. Tretter and Tarek Alsaied

Clinical outcome of biodegradable polymer sirolimus-eluting stent and durable polymer everolimus-eluting stent in patients with diabetes

Diabetes mellitus is a risk for increased incidence of adverse clinical events after percutaneous coronary intervention. However, the difference in the incidence of adverse clinical events according to stent t...

Authors: Ryota Kakizaki, Yoshiyasu Minami, Masahiro Katamine, Aritomo Katsura, Yusuke Muramatsu, Takuya Hashimoto, Kentaro Meguro, Takao Shimohama and Junya Ako

The additive effects of type 2 diabetes mellitus on left ventricular deformation and myocardial perfusion in essential hypertension: a 3.0 T cardiac magnetic resonance study

Type 2 diabetes mellitus (T2DM) increases the risks of heart failure and mortality in patients with hypertension, however the underlying mechanism is unclear. This study aims to investigate the impact of coexi...

Authors: Xue-Ming Li, Li Jiang, Ying-Kun Guo, Yan Ren, Pei-Lun Han, Li-Qing Peng, Rui Shi, Wei-Feng Yan and Zhi-Gang Yang

Major adverse cardiovascular and limb events in patients with diabetes and concomitant peripheral artery disease treated with sodium glucose cotransporter 2 inhibitor versus dipeptidyl peptidase-4 inhibitor

Whether sodium glucose co-transporter 2 inhibitors (SGLT2i) are associated with a lower risk of cardiovascular as well as adverse lower limb events in patients with type-2 diabetes mellitus (T2DM) and concomit...

Authors: Hsin-Fu Lee, Shao-Wei Chen, Jia-Rou Liu, Pei-Ru Li, Lung-Sheng Wu, Shang-Hung Chang, Yung-Hsin Yeh, Chi-Tai Kuo, Yi-Hsin Chan and Lai-Chu See

Characterization of left ventricular myocardial sodium-glucose cotransporter 1 expression in patients with end-stage heart failure

Whereas selective sodium-glucose cotransporter 2 (SGLT2) inhibitors consistently showed cardiovascular protective effects in large outcome trials independent of the presence of type 2 diabetes mellitus (T2DM),...

Authors: Alex Ali Sayour, Attila Oláh, Mihály Ruppert, Bálint András Barta, Eszter Mária Horváth, Kálmán Benke, Miklós Pólos, István Hartyánszky, Béla Merkely and Tamás Radovits

Fibroblast growth factor-23 is associated with imaging markers of diabetic cardiomyopathy and anti-diabetic therapeutics

The biomarker fibroblast growth factor-23 (FGF-23) has been associated with increased cardiovascular morbidity and mortality in both patients with and without type 2 diabetes. The aim of this study was to eval...

Authors: Martin H. Sørensen, Annemie S. Bojer, Niklas R. Jørgensen, David A. Broadbent, Sven Plein, Per L. Madsen and Peter Gæde

Chronic kidney disease and undiagnosed atrial fibrillation in individuals with diabetes

Diabetes is an independent risk factor for atrial fibrillation (AF), which is associated with increases in mortality and morbidity, as well as a diminished quality of life. Renal involvement in diabetes is com...

Authors: Nam Ju Heo, Sang Youl Rhee, Jill Waalen and Steven Steinhubl

Effects of semaglutide on risk of cardiovascular events across a continuum of cardiovascular risk: combined post hoc analysis of the SUSTAIN and PIONEER trials

Semaglutide is a glucagon-like peptide-1 (GLP-1) analog treatment for type 2 diabetes (T2D) available in subcutaneous (s.c.) and oral formulations. Two cardiovascular (CV) outcomes trials showed that in subjec...

Authors: Mansoor Husain, Stephen C. Bain, Anders Gaarsdal Holst, Thomas Mark, Søren Rasmussen and Ildiko Lingvay

The impact of triglyceride-glucose index on incident cardiovascular events during 16 years of follow-up: Tehran Lipid and Glucose Study

To investigate whether the Triglyceride-Glucose index (TyG-index) is associated with increased risk of cardiovascular diseases (CVD)/coronary heart disease (CHD).

Authors: Niloofar Barzegar, Maryam Tohidi, Mitra Hasheminia, Fereidoun Azizi and Farzad Hadaegh

Heterogeneity of antidiabetic treatment effect on the risk of major adverse cardiovascular events in type 2 diabetes: a systematic review and meta-analysis

We explored whether clinically relevant baseline characteristics of patients with type 2 diabetes can modify the effect of glucagon-like peptide-1 receptor agonists (GLP-1 RA) or sodium-glucose cotransporter-2...

Authors: Elvira D’Andrea, Aaron S. Kesselheim, Jessica M. Franklin, Emily H. Jung, Spencer Phillips Hey and Elisabetta Patorno

Exposure-weighted scoring for metabolic syndrome and the risk of myocardial infarction and stroke: a nationwide population-based study

Metabolic syndrome (MetS) status changes over time, but few studies have investigated the relationship between the extent or duration of exposure to MetS and the risk of cardiovascular disease (CVD). We invest...

Authors: Eun Young Lee, Kyungdo Han, Da Hye Kim, Yong-Moon Park, Hyuk-Sang Kwon, Kun-Ho Yoon, Mee Kyoung Kim and Seung-Hwan Lee

Long-term prognostic utility of low-density lipoprotein (LDL) triglyceride in real-world patients with coronary artery disease and diabetes or prediabetes

Recent guidelines highlighted the association between atherosclerosis and triglyceride-enriched lipoproteins in patients with impaired glucose metabolism. However, evidence from prospective studies for long-te...

Authors: Jing-Lu Jin, Hui-Wen Zhang, Ye-Xuan Cao, Hui-Hui Liu, Qi Hua, Yan-Fang Li, Yan Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Rui-Xia Xu, Ying Gao, Xiao-Lin Li, Chuan-Jue Cui, Geng Liu, Jing Sun…

Diabetes as a risk factor for incident peripheral arterial disease in women compared to men: a systematic review and meta-analysis

Previous meta-analyses have suggested that diabetes confers a greater excess risk of coronary heart disease, stroke, vascular dementia, and heart failure in women compared to men. While the underlying mechanis...

Authors: Alyssa Z. Chase-Vilchez, Isaac H. Y. Chan, Sanne A. E. Peters and Mark Woodward

Metformin may adversely affect orthostatic blood pressure recovery in patients with type 2 diabetes: substudy from the placebo-controlled Copenhagen Insulin and Metformin Therapy (CIMT) trial

Metformin has been shown to have both neuroprotective and neurodegenerative effects. The aim of this study was to investigate the effect of metformin in combination with insulin on cardiovascular autonomic neu...

Authors: Christian Stevns Hansen, Louise Lundby-Christiansen, Lise Tarnow, Christian Gluud, Christoffer Hedetoft, Birger Thorsteinsson, Bianca Hemmingsen, Niels Wiinberg, Simone B. Sneppen, Søren S. Lund, Thure Krarup, Sten Madsbad, Thomas Almdal, Bendix Carstensen and Marit E. Jørgensen

Combination therapy with pemafibrate (K-877) and pitavastatin improves vascular endothelial dysfunction in dahl/salt-sensitive rats fed a high-salt and high-fat diet

Statins suppress the progression of atherosclerosis by reducing low-density lipoprotein (LDL) cholesterol levels. Pemafibrate (K-877), a novel selective peroxisome proliferator-activated receptor α modulator, ...

Authors: Masatoki Yoshida, Kazufumi Nakamura, Toru Miyoshi, Masashi Yoshida, Megumi Kondo, Kaoru Akazawa, Tomonari Kimura, Hiroaki Ohtsuka, Yuko Ohno, Daiji Miura and Hiroshi Ito

Effects of empagliflozin versus placebo on cardiac sympathetic activity in acute myocardial infarction patients with type 2 diabetes mellitus: the EMBODY trial

Protection from lethal ventricular arrhythmias leading to sudden cardiac death (SCD) is a crucial challenge after acute myocardial infarction (AMI). Cardiac sympathetic and parasympathetic activity can be noni...

Authors: Wataru Shimizu, Yoshiaki Kubota, Yu Hoshika, Kosuke Mozawa, Shuhei Tara, Yukichi Tokita, Kenji Yodogawa, Yu-ki Iwasaki, Takeshi Yamamoto, Hitoshi Takano, Yayoi Tsukada, Kuniya Asai, Masaaki Miyamoto, Yasushi Miyauchi, Eitaro Kodani, Masahiro Ishikawa…

Sortilin levels correlate with major cardiovascular events of diabetic patients with peripheral artery disease following revascularization: a prospective study

Peripheral artery disease (PAD) represents one of the most relevant vascular complications of type 2 diabetes mellitus (T2DM). Moreover, T2DM patients suffering from PAD have an increased risk of major adverse...

Authors: Federico Biscetti, Elisabetta Nardella, Maria Margherita Rando, Andrea Leonardo Cecchini, Nicola Bonadia, Piergiorgio Bruno, Flavia Angelini, Carmine Di Stasi, Andrea Contegiacomo, Angelo Santoliquido, Dario Pitocco, Raffaele Landolfi and Andrea Flex

Impact of long-term glucose variability on coronary atherosclerosis progression in patients with type 2 diabetes: a 2.3 year follow-up study

Glycemic variability (GV) confers a risk of cardiovascular events. In this study, we aimed to investigate whether long-term GV has an impact on coronary atherosclerosis progression in patients with type 2 diab...

Authors: Suhua Li, Xixiang Tang, Yanting Luo, Bingyuan Wu, Zhuoshan Huang, Zexiong Li, Long Peng, Yesheng Ling, Jieming Zhu, Junlin Zhong, Jinlai Liu and Yanming Chen

Association of glucose uptake of visceral fat and acute myocardial infarction: a pilot ¹⁸F-FDG PET/CT study

Inflamed visceral adipose tissue (VAT) facilitates chronic inflammation in atherosclerotic lesions thereby leading to increased risk of coronary artery disease (CAD). In this study, we evaluated the glucose up...

Authors: Kisoo Pahk, Eung Ju Kim, Chanmin Joung, Hong Seog Seo and Sungeun Kim

Glucose variability and the risks of stroke, myocardial infarction, and all-cause mortality in individuals with diabetes: retrospective cohort study

Previous research regarding long-term glucose variability over several years which is an emerging indicator of glycemic control in diabetes showed several limitations. We investigated whether variability in lo...

Authors: Da Young Lee, Kyungdo Han, Sanghyun Park, Ji Hee Yu, Ji A. Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park and Nan Hee Kim

Arterial stiffness is an independent predictor for risk of mortality in patients with type 2 diabetes mellitus: the REBOUND study

This study aimed to evaluate the benefit of brachial-ankle pulse wave velocity (baPWV) as a noninvasive marker of arterial stiffness for the prediction of all-cause and cause-specific mortality in patients wit...

Authors: Jeong Mi Kim, Sang Soo Kim, In Joo Kim, Jong Ho Kim, Bo Hyun Kim, Mi Kyung Kim, Soon Hee Lee, Chang Won Lee, Min Chul Kim, Jun Hyeob Ahn and Jinmi Kim

Type 2 diabetes is an independent predictor of lowered peak aerobic capacity in heart failure patients with non-reduced or reduced left ventricular ejection fraction

Although type 2 diabetes mellitus (T2DM) is one of the most frequent comorbidities in patients with chronic heart failure (CHF), the effects of T2DM on the exercise capacity of CHF patients are fully unknown. ...

Authors: Takahiro Abe, Takashi Yokota, Arata Fukushima, Naoya Kakutani, Takashi Katayama, Ryosuke Shirakawa, Satoshi Maekawa, Hideo Nambu, Yoshikuni Obata, Katsuma Yamanashi, Ippei Nakano, Shingo Takada, Isao Yokota, Koichi Okita, Shintaro Kinugawa and Toshihisa Anzai

Does acute treatment of dapagliflozin reduce cardiac infarct size through direct cardiac effects or reductions in blood glucose levels?

Authors: Coert J. Zuurbier

Circulating Receptor Activator of Nuclear Factor kB Ligand and triglycerides are associated with progression of lower limb arterial calcification in type 2 diabetes: a prospective, observational cohort study

Lower limb arterial calcification is a frequent, underestimated but serious complication of diabetes. The DIACART study is a prospective cohort study designed to evaluate the determinants of the progression of...

Authors: Olivier Bourron, Franck Phan, Mamadou Hassimiou Diallo, David Hajage, Carole-Elodie Aubert, Aurélie Carlier, Joe-Elie Salem, Christian Funck-Brentano, Salim Kemel, Philippe Cluzel, Alban Redheuil, Jean-Michel Davaine, Ziad Massy, Romuald Mentaverri, Dominique Bonnefont-Rousselot, Philippe Gillery…

Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study

Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stif...

Authors: Minghui Li, Aihua Zhan, Xiao Huang, Lihua Hu, Wei Zhou, Tao Wang, Lingjuan Zhu, Huihui Bao and Xiaoshu Cheng

Long-term trajectories of BMI predict carotid stiffness and plaque volume in type 2 diabetes older adults: a cohort study

High body mass index (BMI) is a risk factor for type 2 diabetes and cardiovascular disease. However, its relationships with indices of carotid stiffness and plaque volume are unclear. We investigated associati...

Authors: Chen Botvin Moshe, Salo Haratz, Ramit Ravona-Springer, Anthony Heymann, Lin Hung-Mo, Michal Schnaider Beeri and David Tanne

Triglyceride glucose index for the detection of asymptomatic coronary artery stenosis in patients with type 2 diabetes

Triglyceride Glucose (TyG) index has been associated with an increased risk in cardiovascular events. Silent coronary disease is common in patients with type 2 diabetes. In Vietnam, a low-middle income country...

Authors: Pham Viet Thai, Hoang Anh Tien, Huynh Van Minh and Paul Valensi