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  1. Content type: Original investigation

    The pathogenesis and cardiovascular impact of type 2 diabetes (T2D) may be different in South Asians compared with other ethnic groups. The phenotypic characterization of diabetic cardiomyopathy remains debate...

    Authors: Elisabeth H. M. Paiman, Huub J. van Eyk, Maurice B. Bizino, Ilona A. Dekkers, Paul de Heer, Johannes W. A. Smit, Ingrid M. Jazet and Hildo J. Lamb

    Citation: Cardiovascular Diabetology 2019 18:133

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  2. Content type: Original investigation

    Diabetes mellitus (DM) is a major cause of morbidity and mortality following heart transplantation (HT), with 21% and 35% of survivors being affected within 1 and 5 years following HT, respectively. Magnesium ...

    Authors: Yael Peled, Eilon Ram, Jacob Lavee, Alexander Tenenbaum, Enrique Z. Fisman, Dov Freimark, Robert Klempfner, Leonid Sternik and Michael Shechter

    Citation: Cardiovascular Diabetology 2019 18:132

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  3. Content type: Original investigation

    Accumulating evidence has shown that type 2 diabetes (T2D) and coronary artery disease (CAD) may stem from a ‘common soil’. The aim of our study was to examine the association between genetic predisposition to...

    Authors: Qiwen Zheng, Jie Jiang, Yong Huo and Dafang Chen

    Citation: Cardiovascular Diabetology 2019 18:131

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  4. Content type: Original investigation

    Cardiovascular diseases (CVDs) are globally the leading cause of death and hypertension is a significant risk factor. Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists has been associated with d...

    Authors: Julie R. Lundgren, Kristine Færch, Daniel R. Witte, Anna E. Jonsson, Oluf Pedersen, Torben Hansen, Torsten Lauritzen, Jens J. Holst, Dorte Vistisen, Marit E. Jørgensen, Signe S. Torekov and Nanna B. Johansen

    Citation: Cardiovascular Diabetology 2019 18:130

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  5. Content type: Commentary

    Four large-scale trials in type 2 diabetes have shown that sodium-glucose cotransporter 2 (SGLT2) inhibitors prevent the occurrence of serious heart failure events. Additionally, the DAPA-HF trial demonstrated...

    Authors: Milton Packer

    Citation: Cardiovascular Diabetology 2019 18:129

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  6. Content type: Original investigation

    Being obese or underweight, and having diabetes are important risk factors for new-onset atrial fibrillation (AF). However, it is unclear whether there is any interaction between body weight and diabetes in re...

    Authors: Yun Gi Kim, Kyung-Do Han, Jong-Il Choi, Ki Yung Boo, Do Young Kim, Suk-Kyu Oh, Kwang-No Lee, Jaemin Shim, Jin Seok Kim and Young-Hoon Kim

    Citation: Cardiovascular Diabetology 2019 18:128

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  7. Content type: Original investigation

    Dyslipidaemia and low-grade inflammation are central in atherogenesis and linked to overweight and physical inactivity. Lifestyle changes are important in secondary prevention of coronary artery disease (CAD)....

    Authors: Lene Rørholm Pedersen, Rasmus Huan Olsen, Christian Anholm, Arne Astrup, Jesper Eugen-Olsen, Mogens Fenger, Lene Simonsen, Rosemary L. Walzem, Steen Bendix Haugaard and Eva Prescott

    Citation: Cardiovascular Diabetology 2019 18:127

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  8. Content type: Original investigation

    Pericoronary adipose tissue inflammation might lead to the development and destabilization of coronary plaques in prediabetic patients. Here, we evaluated inflammation and leptin to adiponectin ratio in perico...

    Authors: Celestino Sardu, Nunzia D’Onofrio, Michele Torella, Michele Portoghese, Francesco Loreni, Simone Mureddu, Giuseppe Signoriello, Lucia Scisciola, Michelangela Barbieri, Maria Rosaria Rizzo, Marilena Galdiero, Marisa De Feo, Maria Luisa Balestrieri, Giuseppe Paolisso and Raffaele Marfella

    Citation: Cardiovascular Diabetology 2019 18:126

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  9. Content type: Original investigation

    Insulin resistance (IR) is considered as a risk factor for atrial fibrillation (AF) even before diabetes develops. The pathophysiology and underlying mechanism are largely unclear.

    Authors: Yi-Hsin Chan, Gwo-Jyh Chang, Ying-Ju Lai, Wei-Jan Chen, Shang-Hung Chang, Li-Man Hung, Chi-Tai Kuo and Yung-Hsin Yeh

    Citation: Cardiovascular Diabetology 2019 18:125

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  10. Content type: Original investigation

    Gene coding mutations found in sodium glucose co-transporters (SGLTs) are known to cause renal glucosuria. SGLT2 inhibitors have recently been shown to be effective hypoglycemic agents as well as possessing ca...

    Authors: Boris Fishman, Gadi Shlomai, Gilad Twig, Estela Derazne, Alexander Tenenbaum, Enrique Z. Fisman, Adi Leiba and Ehud Grossman

    Citation: Cardiovascular Diabetology 2019 18:124

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  11. Content type: Original investigation

    Patients with Diabetes mellitus (DM) are susceptible to coronary artery disease (CAD). However, the impact of DM on plaque progression in the non-stented segments of stent-implanted patients has been rarely re...

    Authors: Rui Shi, Ke Shi, Zhi-gang Yang, Ying-kun Guo, Kai-yue Diao, Yue Gao, Yi Zhang and Shan Huang

    Citation: Cardiovascular Diabetology 2019 18:123

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  12. Content type: Original investigation

    Coronary calcification is associated with high risk for cardiovascular events. However, its impact on plaque vulnerability is incompletely understood. In the present study we defined the intrinsic calcificatio...

    Authors: Sebastian Reith, Andrea Milzi, Enrico Domenico Lemma, Rosalia Dettori, Kathrin Burgmaier, Nikolaus Marx and Mathias Burgmaier

    Citation: Cardiovascular Diabetology 2019 18:122

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  13. Content type: Hypothesis

    Both obesity and type 2 diabetes are important risk factors for atrial fibrillation (AF), possibly because they both cause an expansion of epicardial adipose tissue, which is the source of proinflammatory adip...

    Authors: Milton Packer

    Citation: Cardiovascular Diabetology 2019 18:121

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  14. Content type: Original investigation

    To compare the cardiovascular event risk in type 2 diabetes patients newly receiving dapagliflozin vs. empagliflozin.

    Authors: Shih-Chieh Shao, Kai-Cheng Chang, Ming-Jui Hung, Ning-I Yang, Yuk-Ying Chan, Hui-Yu Chen, Yea-Huei Kao Yang and Edward Chia-Cheng Lai

    Citation: Cardiovascular Diabetology 2019 18:120

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  15. Content type: Original investigation

    Recently, several randomized trials have noted improved outcomes with staged percutaneous coronary intervention (PCI) of nonculprit vessels in patients with ST-segment elevation myocardial infarction (STEMI) a...

    Authors: Kongyong Cui, Shuzheng Lyu, Hong Liu, Xiantao Song, Fei Yuan, Feng Xu, Min Zhang, Wei Wang, Mingduo Zhang, Dongfeng Zhang and Jinfan Tian

    Citation: Cardiovascular Diabetology 2019 18:119

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  16. Content type: Original investigation

    Cardiac allograft vasculopathy (CAV) is a major cause of morbidity and mortality following heart transplantation (HT). Reduced cardiovascular mortality and morbidity have been reported in non-HT patients treat...

    Authors: Eilon Ram, Jacob Lavee, Alexander Tenenbaum, Robert Klempfner, Enrique Z. Fisman, Elad Maor, Tal Ovdat, Sergei Amunts, Leonid Sternik and Yael Peled

    Citation: Cardiovascular Diabetology 2019 18:118

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  17. Content type: Original investigation

    Complication screening is recommended for patients with type 2 diabetes (T2D), but the optimal screening intensity and schedules are unknown. In this study, we evaluated whether intensive versus standard compl...

    Authors: Mario Luca Morieri, Enrico Longato, Marta Mazzucato, Barbara Di Camillo, Arianna Cocchiglia, Lorenzo Gubian, Giovanni Sparacino, Angelo Avogaro, Gian Paolo Fadini and Saula Vigili de Kreutzenberg

    Citation: Cardiovascular Diabetology 2019 18:117

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  18. Content type: Original investigation

    To examine the effects of the DPP-4i sitagliptin on CV outcomes during and after incident MI in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS).

    Authors: Michael A. Nauck, Darren K. McGuire, Karen S. Pieper, Yuliya Lokhnygina, Timo E. Strandberg, Axel Riefflin, Tuncay Delibasi, Eric D. Peterson, Harvey D. White, Russell Scott and Rury R. Holman

    Citation: Cardiovascular Diabetology 2019 18:116

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  19. Content type: Commentary

    EMPA-REG OUTCOME is recognised by international guidelines as a landmark study that showed a significant cardioprotective benefit with empagliflozin in patients with type 2 diabetes (T2D) and cardiovascular di...

    Authors: Guntram Schernthaner, Avraham Karasik, Agnė Abraitienė, Alexander S. Ametov, Zsolt Gaàl, Janusz Gumprecht, Andrej Janež, Susanne Kaser, Katarina Lalić, Boris N. Mankovsky, Evgeny Moshkovich, Marju Past, Martin Prázný, Gabriela Radulian, Lea Smirčić Duvnjak, Ivan Tkáč…

    Citation: Cardiovascular Diabetology 2019 18:115

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  20. Content type: Original investigation

    Cardiac fat is a cardiovascular biomarker but its importance in patients with type 2 diabetes is not clear. The aim was to evaluate the predictive potential of epicardial (EAT), pericardial (PAT) and total car...

    Authors: Regitse H. Christensen, Bernt Johan von Scholten, Christian S. Hansen, Magnus T. Jensen, Tina Vilsbøll, Peter Rossing and Peter G. Jørgensen

    Citation: Cardiovascular Diabetology 2019 18:114

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  21. Content type: Review

    In the light of growing global epidemic of type 2 diabetes mellitus (T2DM), significant efforts are made to discover next-generation biomarkers for early detection of the disease. Multiple mechanisms including...

    Authors: Justyna Pordzik, Daniel Jakubik, Joanna Jarosz-Popek, Zofia Wicik, Ceren Eyileten, Salvatore De Rosa, Ciro Indolfi, Jolanta M. Siller-Matula, Pamela Czajka and Marek Postula

    Citation: Cardiovascular Diabetology 2019 18:113

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  22. Content type: Original investigation

    Recent trials suggested that glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose co-transporter-2 (SGLT-2) inhibitors reduced cardiovascular events. Comparative effectiveness of these new ...

    Authors: Yue Fei, Man-Fung Tsoi and Bernard Man Yung Cheung

    Citation: Cardiovascular Diabetology 2019 18:112

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  23. Content type: Original investigation

    There is no clearly defined temporal relationship between arterial stiffness and diabetes. We aimed to investigate the prospective association between baseline brachial–ankle pulse wave velocity (baPWV) and th...

    Authors: Yuanyuan Zhang, Panpan He, Youbao Li, Yan Zhang, Jianping Li, Min Liang, Guobao Wang, Genfu Tang, Yun Song, Binyan Wang, Chengzhang Liu, Lishun Liu, Yimin Cui, Xiaobin Wang, Yong Huo, Xiping Xu…

    Citation: Cardiovascular Diabetology 2019 18:111

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  24. Content type: Original investigation

    The Y-AIDA study was designed to investigate the renal- and home blood pressure (BP)-modulating effects of add-on dapagliflozin treatment in Japanese individuals with type 2 diabetes mellitus (T2DM) and albumi...

    Authors: Sho Kinguchi, Hiromichi Wakui, Yuzuru Ito, Yoshinobu Kondo, Kengo Azushima, Uru Osada, Tadashi Yamakawa, Tamio Iwamoto, Jun Yutoh, Toshihiro Misumi, Kazutaka Aoki, Gen Yasuda, Taishi Yoshii, Takayuki Yamada, Syuji Ono, Tomoko Shibasaki-Kurita…

    Citation: Cardiovascular Diabetology 2019 18:110

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  25. Content type: Original investigation

    Inflammation and insulin resistance play crucial roles in the development of type 2 diabetes mellitus (T2DM). We aim to examine the temporal relationship between high-sensitivity C-reactive protein (hsCRP) and...

    Authors: Yinkun Yan, Shengxu Li, Yang Liu, Lydia Bazzano, Jiang He, Jie Mi and Wei Chen

    Citation: Cardiovascular Diabetology 2019 18:109

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  26. Content type: Original investigation

    The territory of the right coronary artery (RCA) is smaller than that of the left anterior descending artery. Previous studies have reported conflicting results when considering whether stable RCA-chronic tota...

    Authors: Yunfeng Yan, Mingduo Zhang, Fei Yuan, Hong Liu, Di Wu, Yudong Fan, Xinjing Guo, Feng Xu, Min Zhang, Quanming Zhao and Shuzheng Lyu

    Citation: Cardiovascular Diabetology 2019 18:108

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  27. Content type: Original investigation

    Heart failure with preserved ejection fraction (HFpEF) is a difficult disease with high morbidity and mortality rates and lacks an effective treatment. Here, we report the therapeutic effect of dapagliflozin, ...

    Authors: Nannan Zhang, Bin Feng, Xuexing Ma, Kangyun Sun, Guidong Xu and Yafeng Zhou

    Citation: Cardiovascular Diabetology 2019 18:107

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  28. Content type: Original investigation

    Cardiovascular outcome trials have documented a strong benefit of sodium glucose cotransporter-2 inhibitors (SGLT2i) on the risk of hospitalization for heart failure (HF) in patients with type 2 diabetes (T2D)...

    Authors: Benedetta Maria Bonora, Saula Vigili de Kreutzenberg, Angelo Avogaro and Gian Paolo Fadini

    Citation: Cardiovascular Diabetology 2019 18:106

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  29. Content type: Original investigation

    Although adiponectin is a major adipocytokine that affects the pathogenesis of various cardiovascular diseases, its clinical significance in stroke remains controversial. The purpose of this study was to asses...

    Authors: Zengliang Wang, Bo Li, Yongxin Wang, Aisha Maimaitili, Hu Qin, Geng Dangmurenjiafu and Shuo Wang

    Citation: Cardiovascular Diabetology 2019 18:105

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  30. Content type: Original investigation

    To examine the effect of high-intensity interval training (HIIT) on metabolic syndrome (MetS) and body composition in cardiac rehabilitation (CR) patients with myocardial infarction (MI).

    Authors: Yaoshan Dun, Randal J. Thomas, Joshua R. Smith, Jose R. Medina-Inojosa, Ray W. Squires, Amanda R. Bonikowske, Hsuhang Huang, Suixin Liu and Thomas P. Olson

    Citation: Cardiovascular Diabetology 2019 18:104

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  31. Content type: Original investigation

    We investigated the association regarding severe hypoglycemia episodes with cardiovascular disease risk and all-cause mortality in patients with type 2 diabetes.

    Authors: Jae-Seung Yun, Yong-Moon Park, Kyungdo Han, Seon-Ah Cha, Yu-Bae Ahn and Seung-Hyun Ko

    Citation: Cardiovascular Diabetology 2019 18:103

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  32. Content type: Original investigation

    Myocardial infarction is the main mortality cause in patients with type 2 diabetes (T2DM). Endothelial dysfunction due to reduced bioavailability of nitric oxide (NO) is an early step of atherogenesis. Asymmet...

    Authors: Gaia Chiara Mannino, Serena Pezzilli, Carolina Averta, Anastasia Fuoco, Rosangela Spiga, Elettra Mancuso, Concetta Di Fatta, Francesco Perticone, Sabrina Prudente, Vincenzo Trischitta, Francesco Andreozzi and Giorgio Sesti

    Citation: Cardiovascular Diabetology 2019 18:102

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  33. Content type: Correction

    Following publication of the original article [1], the authors reported an error in Fig. 3. The bars in the upper right panel that represent heart rate in placebo treated patients is not correct.

    Authors: Maurice B. Bizino, Ingrid M. Jazet, Jos J. M. Westenberg, Huub J. van Eyk, Elisabeth H. M. Paiman, Jan W. A. Smit and Hildebrandus J. Lamb

    Citation: Cardiovascular Diabetology 2019 18:101

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    The original article was published in Cardiovascular Diabetology 2019 18:55

  34. Content type: Original investigation

    Adverse cardiac remodeling after ST-segment elevation myocardial infarction (STEMI) is a major cause for poor cardiovascular outcomes such as heart failure. The predisposing factors and underlying mechanisms r...

    Authors: Chen Die Yang, Ying Shen, Lin Lu, Feng Hua Ding, Zhen Kun Yang, Rui Yan Zhang, Wei Feng Shen, Wei Jin and Xiao Qun Wang

    Citation: Cardiovascular Diabetology 2019 18:100

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  35. Content type: Review

    To summarize the four recent sodium-glucose cotransporter 2 inhibitor (SGLT2i) trials: Dapagliflozin Effect on CardiovascuLAR Events (DECLARE-TIMI 58), CANagliflozin CardioVascular Assessment Study (CANVAS) Pr...

    Authors: Aaron Y. Kluger, Kristen M. Tecson, Andy Y. Lee, Edgar V. Lerma, Janani Rangaswami, Norman E. Lepor, Michael E. Cobble and Peter A. McCullough

    Citation: Cardiovascular Diabetology 2019 18:99

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  36. Content type: Original investigation

    Large changes in health behaviors achieved through intensive lifestyle intervention programs improve cardiovascular disease (CVD) risk factors among adults with type 2 diabetes. However, such interventions are...

    Authors: Jean Strelitz, Amy L. Ahern, Gráinne H. Long, Clare E. Boothby, Nicholas J. Wareham and Simon J. Griffin

    Citation: Cardiovascular Diabetology 2019 18:98

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  37. Content type: Original investigation

    Associations between sex hormones and vascular remodeling have been extensively studied, but the results vary widely among different races and sex. We aimed to investigate whether total testosterone (TT), estr...

    Authors: Chiyu Wang, Wen Zhang, Yuying Wang, Heng Wan, Yi Chen, Fangzhen Xia, Kun Zhang, Ningjian Wang and Yingli Lu

    Citation: Cardiovascular Diabetology 2019 18:97

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  38. Content type: Original investigation

    Metformin is the most widely prescribed drug to lower glucose and has a definitive effect on the cardiovascular system. The goal of this systematic review and meta-analysis is to assess the effects of metformi...

    Authors: Yechen Han, Hongzhi Xie, Yongtai Liu, Peng Gao, Xufei Yang and Zhujun Shen

    Citation: Cardiovascular Diabetology 2019 18:96

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  39. Content type: Original investigation

    It has been reported that the triglyceride-glucose (TyG) index may serve as a simple and credible surrogate marker of insulin resistance (IR). However, its association with macrovascular and microvascular dama...

    Authors: Song Zhao, Shikai Yu, Chen Chi, Ximin Fan, Jiamin Tang, Hongwei Ji, Jiadela Teliewubai, Yi Zhang and Yawei Xu

    Citation: Cardiovascular Diabetology 2019 18:95

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  40. Content type: Commentary

    The definition of class effect for SGLT-2 inhibitors may be based on three concepts: a similar chemical structure, a similar mechanism of action and similar pharmacological effects. We have also assumed that a...

    Authors: Dario Giugliano and Katherine Esposito

    Citation: Cardiovascular Diabetology 2019 18:94

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  41. Content type: Original investigation

    Individuals with diabetes have remarkably high rates of cardiovascular morbidity and mortality. However, the incremental cardiovascular risk in diabetes is heterogeneous and has often been related to renal inv...

    Authors: Ana Palanca, Esmeralda Castelblanco, Àngels Betriu, Hèctor Perpiñán, Berta Soldevila, José Manuel Valdivielso, Marcelino Bermúdez-Lopez, Carlos Puig-Jové, Manel Puig-Domingo, Per-Henrik Groop, Elvira Fernández, Núria Alonso and Didac Mauricio

    Citation: Cardiovascular Diabetology 2019 18:93

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  42. Content type: Original investigation

    Degenerative aortic stenosis (AS), a disease of the elderly, frequently coexists with concomitant diseases, including type 2 diabetes (T2DM) which amplifies the cardiovascular (CV) risk. T2DM affects left vent...

    Authors: Ewa Czestkowska, Agnieszka Rożanowska, Dorota Długosz, Klaudiusz Bolt, Jolanta Świerszcz, Olga Kruszelnicka, Bernadeta Chyrchel and Andrzej Surdacki

    Citation: Cardiovascular Diabetology 2019 18:92

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  43. Content type: Original investigation

    Glucagon-like peptide-1 (GLP-1) treatment has been shown to reduce stroke incidence in diabetes and also to be neuroprotective in experimental stroke models. The prognostic value of endogenous levels of GLP-1 ...

    Authors: Martin Larsson, Cesare Patrone, Mia von Euler, Jens J. Holst and David Nathanson

    Citation: Cardiovascular Diabetology 2019 18:91

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  44. Content type: Original investigation

    Experimental and clinical data indicate a major influence of diabetes on atherogenesis. We aimed to assess whether the effect of diabetes on long-term mortality in asymptomatic patient with carotid stenosis is...

    Authors: Matthias Hoke, Martin Schillinger, Erich Minar, Georg Goliasch, Christoph J. Binder and Florian J. Mayer

    Citation: Cardiovascular Diabetology 2019 18:90

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  45. Content type: Original investigation

    The triglyceride-glucose index (TyG index) is a tool for insulin resistance evaluation, however, little is known about its association with coronary artery disease (CAD), which is the major cardiovascular deat...

    Authors: Alessandra da Silva, Ana Paula Silva Caldas, Helen Hermana Miranda Hermsdorff, Ângela Cristine Bersch-Ferreira, Camila Ragne Torreglosa, Bernardete Weber and Josefina Bressan

    Citation: Cardiovascular Diabetology 2019 18:89

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  46. Content type: Original investigation

    Hypertension is one of the strongest risk factors for stroke in the general population, while systolic blood pressure has been shown to independently increase the risk of stroke in type 1 diabetes. The aim of ...

    Authors: Stefanie Hägg-Holmberg, Emma H. Dahlström, Carol M. Forsblom, Valma Harjutsalo, Ron Liebkind, Jukka Putaala, Turgut Tatlisumak, Per-Henrik Groop and Lena M. Thorn

    Citation: Cardiovascular Diabetology 2019 18:88

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  47. Content type: Original investigation

    South Asians have a high risk to develop type 2 diabetes, which may be related to substantial ectopic fat deposition. Since glucagon-like peptide-1 analogues can reduce ectopic fat accumulation, the aim of the...

    Authors: Huub J. van Eyk, Elisabeth H. M. Paiman, Maurice B. Bizino, Paul de Heer, Petronella H. Geelhoed-Duijvestijn, Aan V. Kharagjitsingh, Johannes W. A. Smit, Hildo J. Lamb, Patrick C. N. Rensen and Ingrid M. Jazet

    Citation: Cardiovascular Diabetology 2019 18:87

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  48. Content type: Original investigation

    Branched chain amino acids (BCAA) can impair insulin signaling, and cardiac insulin resistance can occur in the failing heart. We, therefore, determined if cardiac BCAA accumulation occurs in patients with dil...

    Authors: Golam M. Uddin, Liyan Zhang, Saumya Shah, Arata Fukushima, Cory S. Wagg, Keshav Gopal, Rami Al Batran, Simran Pherwani, Kim L. Ho, Jamie Boisvenue, Qutuba G. Karwi, Tariq Altamimi, David S. Wishart, Jason R. B. Dyck, John R. Ussher, Gavin Y. Oudit…

    Citation: Cardiovascular Diabetology 2019 18:86

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  49. Content type: Original investigation

    Recent large-scale clinical trials have shown that SGLT2-inhibitors reduce cardiovascular events in diabetic patients. However, the regulation and functional role of cardiac sodium–glucose cotransporter (SGLT1...

    Authors: Akira Yoshii, Tomohisa Nagoshi, Yusuke Kashiwagi, Haruka Kimura, Yoshiro Tanaka, Yuhei Oi, Keiichi Ito, Takuya Yoshino, Toshikazu D. Tanaka and Michihiro Yoshimura

    Citation: Cardiovascular Diabetology 2019 18:85

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  50. Content type: Review

    Heart disease continues to affect health outcomes globally, accounting for a quarter of all deaths in the United States. Despite the improvement in the development and implementation of guideline-directed medi...

    Authors: Omar Sheikh, Anthony G. Vande Hei, Ayman Battisha, Tarek Hammad, Son Pham and Robert Chilton

    Citation: Cardiovascular Diabetology 2019 18:84

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