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  1. Inflammation plays an important role in coronary artery disease from the initiation of endothelial dysfunction to plaque formation to final rupture of the plaque. In this study, we investigated the potential p...

    Authors: Hyun Min Kim, Byung-Wan Lee, Young-Mi Song, Won Jin Kim, Hyuk-Jae Chang, Dong-Hoon Choi, Hee Tae Yu, EunSeok Kang, Bong Soo Cha and Hyun Chul Lee
    Citation: Cardiovascular Diabetology 2012 11:84
    Content type: Original investigation Published on:

  2. We used cardiovascular magnetic resonance (CMR) to investigate the association between epicardial adipose tissue (EAT) thickness and silent myocardial ischemia, as well as coronary artery stenosis, in asymptom...

    Authors: Hyun Min Kim, Kwang Joon Kim, Hye-Jeong Lee, Hee Tae Yu, Jae Hoon Moon, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Byung-Wan Lee and Young Jin Kim
    Citation: Cardiovascular Diabetology 2012 11:83
    Content type: Original investigation Published on:

  3. Diabetes has been shown to be independent predictor of restenosis after percutaneous coronary intervention (PCI). The aim of the present study was to investigate whether a pre- and post-procedural glycaemic co...

    Authors: Seyed Ebrahim Kassaian, Hamidreza Goodarzynejad, Mohammad Ali Boroumand, Mojtaba Salarifar, Farzad Masoudkabir, Mohammad Reza Mohajeri-Tehrani, Hamidreza Pourhoseini, Saeed Sadeghian, Narges Ramezanpour, Mohammad Alidoosti, Elham Hakki, Soheil Saadat and Ebrahim Nematipour
    Citation: Cardiovascular Diabetology 2012 11:82
    Content type: Original investigation Published on:

  4. Different population studies have reported gender difference in carotid intima-media thickness (CIMT), which is proved to be a risk factor of cardiovascular diseases. However, few longitudinal researches exami...

    Authors: Bo Zhao, Yanping Liu, Yifei Zhang, Yuhong Chen, Zhifang Yang, Ying Zhu and Weiwei Zhan
    Citation: Cardiovascular Diabetology 2012 11:51
    Content type: Original investigation Published on:

  6. Recent data suggest that concentrations of lipoprotein(a) [Lp(a)] may be inversely associated with the risk of diabetes. This study analyzed the relationships between Lp(a) and both diabetes and insulin resist...

    Authors: Mauro Boronat, Pedro Saavedra, Nuria Pérez-Martín, María J López-Madrazo, Carlos Rodríguez-Pérez and Francisco J Nóvoa
    Citation: Cardiovascular Diabetology 2012 11:81
    Content type: Original investigation Published on:

  7. Low serum amylase is likely to be associated with obesity and metabolic abnormalities, which are often accompanied by impaired insulin action. However, it is unclear whether low serum amylase is associated wit...

    Authors: Toshitaka Muneyuki, Kei Nakajima, Atsushi Aoki, Masashi Yoshida, Hiroshi Fuchigami, Hiromi Munakata, San-e Ishikawa, Hitoshi Sugawara, Masanobu Kawakami, Shin-ichi Momomura and Masafumi Kakei
    Citation: Cardiovascular Diabetology 2012 11:80
    Content type: Original investigation Published on:

  8. The risk of cardiovascular complication in a diabetes patient is similar to that in a nondiabetic patient with a history of myocardial infarction. Although intensive control of glycemia achieved by conventiona...

    Authors: Lisa Kitasato, Taiki Tojo, Yuko Hatakeyama, Ryo Kameda, Takehiro Hashikata and Minako Yamaoka-Tojo
    Citation: Cardiovascular Diabetology 2012 11:79
    Content type: Review Published on:

  9. Diabetes (DM) deteriorates the prognosis in patients with coronary heart disease. However, the prognostic value of different glucose abnormalities (GA) other than DM in subjects with acute myocardial infarctio...

    Authors: Michal Mazurek, Jacek Kowalczyk, Radoslaw Lenarczyk, Teresa Zielinska, Agnieszka Sedkowska, Patrycja Pruszkowska-Skrzep, Andrzej Swiatkowski, Beata Sredniawa, Oskar Kowalski, Lech Polonski, Krzysztof Strojek and Zbigniew Kalarus
    Citation: Cardiovascular Diabetology 2012 11:78
    Content type: Original investigation Published on:

  10. The metabolic syndrome (MetS) is associated with increased risk of cardiovascular disease. In this study, we examine if metabolic syndrome predicts progression of atherosclerosis over 13 years.

    Authors: Marit Herder, Kjell Arne Arntzen, Stein Harald Johnsen and Ellisiv B Mathiesen
    Citation: Cardiovascular Diabetology 2012 11:77
    Content type: Original investigation Published on:

    The Erratum to this article has been published in Cardiovascular Diabetology 2013 12:144

  11. Individuals who had normoglycemia but whose 2-hour plasma glucose (2hPG) concentrations did not return to the fasting plasma glucose (FPG) levels during an oral glucose tolerance test (OGTT) have been shown to...

    Authors: Feng Ning, Lei Zhang, Jacqueline M Dekker, Altan Onat, Coen DA Stehouwer, John S Yudkin, Tiina Laatikainen, Jaakko Tuomilehto, Kalevi Pyörälä and Qing Qiao
    Citation: Cardiovascular Diabetology 2012 11:76
    Content type: Original investigation Published on:

  12. Diabetes remains a significant risk factor for restenosis/thrombosis following stenting. Although vascular healing responses following drug-eluting stent (DES) treatment have been characterized previously in h...

    Authors: Alexander Sheehy, Steven Hsu, Amelie Bouchard, Pablo Lema, Claudine Savard, Louis-Georges Guy, Julie Tai and Igor Polyakov
    Citation: Cardiovascular Diabetology 2012 11:75
    Content type: Original investigation Published on:

  13. Glucose intolerance is a major health problem and is associated with increased risk of progression to type 2 diabetes mellitus and cardiovascular disease. However, whether glucose intolerance is related to imp...

    Authors: Charissa E van den Brom, Carolien SE Bulte, B Margreet Kloeze, Stephan A Loer, Christa Boer and R Arthur Bouwman
    Citation: Cardiovascular Diabetology 2012 11:74
    Content type: Original investigation Published on:

  14. Alpha-lipoic acid (ALA), a naturally occurring compound, exerts powerful protective effects in various cardiovascular disease models. However, its role in protecting against diabetic cardiomyopathy (DCM) has n...

    Authors: Chun-jun Li, Lin Lv, Hui Li and De-min Yu
    Citation: Cardiovascular Diabetology 2012 11:73
    Content type: Original investigation Published on:

  15. Recent studies have shown that fatty acid-binding protein 4 (FABP4) plasma levels are associated with impaired endothelial function in type 2 diabetes (T2D). In this work, we analysed the effect of FABP4 on th...

    Authors: Gemma Aragonès, Paula Saavedra, Mercedes Heras, Anna Cabré, Josefa Girona and Lluís Masana
    Citation: Cardiovascular Diabetology 2012 11:72
    Content type: Original investigation Published on:

  16. The aim of our study was to explore and evaluate the relationship between insulin resistance and progression of coronary atherosclerotic plaques. With the great burden coronary heart disease is imposing on ind...

    Authors: Xuanqi An, Dong Yu, Ruiyan Zhang, Jinzhou Zhu, Run Du, Yuhang Shi and Xiaowei Xiong
    Citation: Cardiovascular Diabetology 2012 11:71
    Content type: Original investigation Published on:

  17. Although a variety of treatment guidelines for Type 2 diabetes patients are available, a majority of patients does not achieve recommended targets. We aimed to characterise Type 2 diabetes patients from Swiss ...

    Authors: Anja Frei, Stefanie Herzog, Katja Woitzek, Ulrike Held, Oliver Senn, Thomas Rosemann and Corinne Chmiel
    Citation: Cardiovascular Diabetology 2012 11:70
    Content type: Original investigation Published on:

  19. Type 2 diabetes (2DM), obesity, and coronary artery disease (CAD) are frequently coexisted being as key components of metabolic syndrome. Whether there is shared genetic background underlying these diseases re...

    Authors: Chaoneng Wu, Yunguo Gong, Jie Yuan, Hui Gong, Yunzeng Zou and Junbo Ge
    Citation: Cardiovascular Diabetology 2012 11:68
    Content type: Review Published on:

  20. In spite of the current optimal therapy, the mortality of patients with ischemic heart disease (IHD) remains high, particularly in cases with diabetes mellitus (DM) as a co-morbidity. Myocardial infarct size i...

    Authors: Takayuki Miki, Takahito Itoh, Daisuke Sunaga and Tetsuji Miura
    Citation: Cardiovascular Diabetology 2012 11:67
    Content type: Review Published on:

  21. It has been suggested that the antioxidant properties of olmesartan (OLM), an angiotensin II type 1 receptor (AT1R) blocker, contribute to renal protection rather than blood pressure lowering effects despite the ...

    Authors: Yao-Chen Chuang, Ming-Shiou Wu, Yi-Kai Su and Kwang-Ming Fang
    Citation: Cardiovascular Diabetology 2012 11:66
    Content type: Original investigation Published on:

  22. Previous studies suggested that the RhoA/ROCK pathway may contribute to vascular complications in diabetes. The present study was designed to investigate whether ROCK inhibitor fasudil could prevent high gluco...

    Authors: Hailing Li, Wenhui Peng, Weixia Jian, Yuanmin Li, Qi Li, Weiming Li and Yawei Xu
    Citation: Cardiovascular Diabetology 2012 11:65
    Content type: Original investigation Published on:

  23. Glucagon like peptide-1 (GLP-1) receptor agonist treatment may improve endothelial function via direct and indirect mechanisms. We compared the acute and chronic effects of the GLP-1 receptor agonist exenatide...

    Authors: Aaron S Kelly, Richard M Bergenstal, J Michael Gonzalez-Campoy, Harold Katz and Alan J Bank
    Citation: Cardiovascular Diabetology 2012 11:64
    Content type: Original investigation Published on:

  24. The heart derives energy from a wide variety of substrates including fatty acids, carbohydrates, ketones, and amino acids. The healthy heart generates up to 30% of its ATP from glucose. Under conditions of car...

    Authors: Lauren Aerni-Flessner, Melissa Abi-Jaoude, Amanda Koenig, Maria Payne and Paul W Hruz
    Citation: Cardiovascular Diabetology 2012 11:63
    Content type: Original investigation Published on:

  25. The relationship between body composition parameters such as thigh and calf circumference and insulin resistance or atherosclerosis in type 2 diabetes is poorly understood. The aim of this study was to investi...

    Authors: Jong Suk Park, Min Ho Cho, Chul Woo Ahn, Kyung Rae Kim and Kap Bum Huh
    Citation: Cardiovascular Diabetology 2012 11:62
    Content type: Original investigation Published on:

  26. Insulin resistance (IR) is the major driving force behind development and progression of atherosclerosis in patients with nonalcoholic fatty liver disease (NAFLD). Therefore, correction of IR is a relevant the...

    Authors: Marina Shargorodsky, Elena Omelchenko, Zipora Matas, Mona Boaz and Dov Gavish
    Citation: Cardiovascular Diabetology 2012 11:61
    Content type: Original investigation Published on:

  27. Diabetic patients present with an accelerated atherosclerotic process and an increased risk for future cardiovascular events. In addition to the risk imposed by the disease itself, pharmacological treatment ad...

    Authors: Robert Klempfner, Jonathan Leor, Alexander Tenenbaum, Enrique Z Fisman and Ilan Goldenberg
    Citation: Cardiovascular Diabetology 2012 11:60
    Content type: Study protocol Published on:

  28. Women with previous gestational diabetes mellitus (pGDM) face a higher risk of developing type 2 diabetes and, consequently, a higher cardiovascular risk. This study aimed to compare the carotid intima-media t...

    Authors: Claudia Maria Vilas Freire, Felipe Batista Lima Barbosa, Maria Cristina C de Almeida, Paulo Augusto Carvalho Miranda, Márcia Melo Barbosa, Anelise Impeliziere Nogueira, Milena Moreira Guimarães, Maria do Carmo Pereira Nunes and Antônio Ribeiro-Oliveira Jr
    Citation: Cardiovascular Diabetology 2012 11:59
    Content type: Original investigation Published on:

  29. Diabetes mellitus is associated with micro- and macrovascular complications and increased cardiovascular risk. Elevated levels of serum asymmetric dimethylarginine (ADMA) may be responsible for endothelial dys...

    Authors: Erik Salum, Priit Kampus, Mihkel Zilmer, Jaan Eha, Mark Butlin, Alberto P Avolio, Taavi Põdramägi, Andres Arend, Marina Aunapuu and Jaak Kals
    Citation: Cardiovascular Diabetology 2012 11:58
    Content type: Original investigation Published on:

  30. Calcium (Ca2+) handling proteins are known to play a pivotal role in the pathophysiology of cardiomyopathy. However little is known about early changes in the diabetic heart and the impact of insulin treatment...

    Authors: Sabine Fredersdorf, Christian Thumann, Wolfram H Zimmermann, Roland Vetter, Tobias Graf, Andreas Luchner, Günter AJ Riegger, Heribert Schunkert, Thomas Eschenhagen and Joachim Weil
    Citation: Cardiovascular Diabetology 2012 11:57
    Content type: Original investigation Published on:

  31. The prevention of type 2 diabetes is a globally recognised health care priority, but there is a lack of rigorous research investigating optimal methods of translating diabetes prevention programmes, based on t...

    Authors: Laura J Gray, Kamlesh Khunti, Sian Williams, Stephanie Goldby, Jacqui Troughton, Thomas Yates, Alastair Gray and Melanie J Davies
    Citation: Cardiovascular Diabetology 2012 11:56
    Content type: Study protocol Published on:

  32. Increased low-density lipoprotein cholesterol (LDL) concentration is associated with increased risk of coronary heart disease (CHD) but a substantial risk of cardiovascular disease often remains after LDL conc...

    Authors: Dong-Sik Cho, Sookyoung Woo, Seonwoo Kim, Christopher D Byrne, Joon-Hyuk Kong and Ki-Chul Sung
    Citation: Cardiovascular Diabetology 2012 11:55
    Content type: Original investigation Published on:

  33. Uncontrolled blood pressure (BP) is a significant contributor of morbidity and even mortality in type 2 diabetes (T2D) patients. This study was done to determine the significant determinants of uncontrolled bl...

    Authors: Boon How Chew, Ismail Mastura, Sazlina Shariff-Ghazali, Ping Yein Lee, Ai Theng Cheong, Zaiton Ahmad, Sri Wahyu Taher, Jamaiyah Haniff, Feisul Idzwan Mustapha and Mohd Adam Bujang
    Citation: Cardiovascular Diabetology 2012 11:54
    Content type: Original investigation Published on:

  34. Both angiotensin II type I receptor blockers (ARBs) and calcium channel blockers (CCBs) are widely used antihypertensive drugs. Many clinical studies have demonstrated and compared the organ-protection effects...

    Authors: Yayoi Nishida, Yasuo Takahashi, Tomohiro Nakayama and Satoshi Asai
    Citation: Cardiovascular Diabetology 2012 11:53
    Content type: Original investigation Published on:

  35. Admission hyperglycaemia is associated with mortality in patients with acute coronary syndrome (ACS), but controversy exists whether hyperglycaemia uniformly affects both genders. We evaluated coronary risk fa...

    Authors: Julio Yoshio Takada, Rogério Bicudo Ramos, Larissa Cardoso Roza, Solange Desiree Avakian, José Antonio Franchini Ramires and Antonio de Pádua Mansur
    Citation: Cardiovascular Diabetology 2012 11:47
    Content type: Original investigation Published on:

  36. The published literature regarding the relationships between retinol-binding protein 4 (RBP4) and cardiometabolic risk factors and subclinical atherosclerosis is conflicting, likely due, in part, to limitation...

    Authors: Gary Huang, Dan Wang, Unab I Khan, Irfan Zeb, JoAnn E Manson, Virginia Miller, Howard N Hodis, Matthew J Budoff, George R Merriam, Mitchell S Harman, Eliot A Brinton, Marcelle I Cedars, Yali Su, Rogerio A Lobo, Frederick Naftolin, Nanette Santoro…
    Citation: Cardiovascular Diabetology 2012 11:52
    Content type: Original investigation Published on:

  37. Although most deaths among patients with type 2 diabetes (T2D) are attributable to cardiovascular disease, modifiable cardiovascular risk factors appear to be inadequately treated in medical practice. The aim ...

    Authors: Ina-Maria Rückert, Michaela Schunk, Rolf Holle, Sabine Schipf, Henry Völzke, Alexander Kluttig, Karin-Halina Greiser, Klaus Berger, Grit Müller, Ute Ellert, Hannelore Neuhauser, Wolfgang Rathmann, Teresa Tamayo, Susanne Moebus, Silke Andrich and Christa Meisinger
    Citation: Cardiovascular Diabetology 2012 11:50
    Content type: Original investigation Published on:

  38. Chronic elevation of glucose level activates vascular inflammation and increases endothelial adhesiveness to monocytes, an early sign of atherogenesis. This study aimed to elucidate the detailed mechanisms of ...

    Authors: Jia-Shiong Chen, Yung-Hsiang Chen, Po-Hsun Huang, Hsiao-Ya Tsai, Yuh-Lien Chen, Shing-Jong Lin and Jaw-Wen Chen
    Citation: Cardiovascular Diabetology 2012 11:49
    Content type: Original investigation Published on:

  39. Genome-wide association studies (GWAS) are useful to reveal an association between single nucleotide polymorphisms and different measures of obesity. A multitude of new loci has recently been reported, but the...

    Authors: Peter M Schmid, Iris Heid, Christa Buechler, Andreas Steege, Markus Resch, Christoph Birner, Dierk H Endemann, Guenter A Riegger and Andreas Luchner
    Citation: Cardiovascular Diabetology 2012 11:48
    Content type: Original investigation Published on:

  40. Endothelial progenitor cells (EPCs), especially late EPCs, play a critical role in endothelial maintenance and repair, and postnatal vasculogenesis. Advanced glycation end products (AGEs) have been shown to im...

    Authors: Hong Li, Xiaoyun Zhang, Xiumei Guan, Xiaodong Cui, Yuliang Wang, Hairong Chu and Min Cheng
    Citation: Cardiovascular Diabetology 2012 11:46
    Content type: Original investigation Published on:

  42. Metabolic abnormalities have a cumulative effect on development of diabetes, but only central obesity has been defined as the essential criterion of metabolic syndrome (MetS) by the International Diabetes Fede...

    Authors: I-Te Lee, Yen-Feng Chiu, Chii-Min Hwu, Chih-Tsueng He, Fu-Tien Chiang, Yu-Chun Lin, Themistocles Assimes, J David Curb and Wayne H-H Sheu
    Citation: Cardiovascular Diabetology 2012 11:43
    Content type: Original investigation Published on:

  43. Connective tissue growth factor (CTGF) has been implicated in the cardiac and kidney complications of type 2 diabetes, and the CTGF − 945 G/C polymorphism is associated with susceptibility to systemic sclerosis, ...

    Authors: Sheila K Patel, Bryan Wai, Richard J MacIsaac, Sharon Grant, Elena Velkoska, Michelle Ord, Sianna Panagiotopoulos, George Jerums, Piyush M Srivastava and Louise M Burrell
    Citation: Cardiovascular Diabetology 2012 11:42
    Content type: Original investigation Published on:

  44. Uncoupling protein 2 (UCP2) gene polymorphisms have been reported as genetic risk factors for obesity and type 2 diabetes mellitus (T2DM). We examined the association of commonly observed UCP2 G(−866)A (rs6593...

    Authors: Sukma Oktavianthi, Hidayat Trimarsanto, Clarissa A Febinia, Ketut Suastika, Made R Saraswati, Pande Dwipayana, Wibowo Arindrarto, Herawati Sudoyo and Safarina G Malik
    Citation: Cardiovascular Diabetology 2012 11:41
    Content type: Original investigation Published on:

  45. Serum C-reactive protein (CRP) and leptin levels have been independently associated with the cardiovascular risk factors. The aim of the present study was to determine if their serum levels were associated wit...

    Authors: Feng-Hsiang Chiu, Chung Hsun Chuang, Wen-Cheng Li, Yi-Ming Weng, Wen-Chih Fann, Hsiang-Yun Lo, Cheng Sun and Shih-Hao Wang
    Citation: Cardiovascular Diabetology 2012 11:40
    Content type: Original investigation Published on:

  47. Reduced lung function is associated with incident insulin resistance and diabetes. The aim of this study was to assess the relationship between lung function and incident type 2 diabetes in Korean men.

    Authors: Chang-Hee Kwon, Eun-Jung Rhee, Jae-Uk Song, Jung-Tae Kim, Hyon Joo Kwag and Ki-Chul Sung
    Citation: Cardiovascular Diabetology 2012 11:38
    Content type: Original investigation Published on:

  49. The most common apolipoprotein E (apoE) gene polymorphism has been found to influence plasma lipid concentration and its correlation with coronary artery disease (CAD) has been extensively investigated in the ...

    Authors: Rajesh Chaudhary, Atip Likidlilid, Thavatchai Peerapatdit, Damras Tresukosol, Sorachai Srisuma, Suphachai Ratanamaneechat and Charn Sriratanasathavorn
    Citation: Cardiovascular Diabetology 2012 11:36
    Content type: Original investigation Published on:

  50. Health utility (HU) measures are used as overall measures of quality of life and to determine quality adjusted life years (QALYs) in economic analyses. We compared baseline values of three HUs including Short ...

    Authors: Dennis W Raisch, Patricia Feeney, David C Goff Jr, KM Venkat Narayan, Patrick J O’Connor, Ping Zhang, Don G Hire and Mark D Sullivan
    Citation: Cardiovascular Diabetology 2012 11:35
    Content type: Original investigation Published on:
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