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  1. Osteoprotegerin is a member of the tumor necrosis factor-related family and inhibits RANK stimulation of osteoclast formation as a soluble decoy receptor. The goal of this study was to determine the relationsh...

    Authors: Atsushi Aoki, Miho Murata, Tomoko Asano, Aki Ikoma, Masami Sasaki, Tomoyuki Saito, Taeko Otani, Sachimi Jinbo, Nahoko Ikeda, Masanobu Kawakami and San-e Ishikawa
    Citation: Cardiovascular Diabetology 2013 12:11
    Content type: Original investigation Published on:

  2. High LDL-cholesterol (LDL-C) and glucose levels are risk factors for ischemic heart disease (IHD) in middle-aged diabetic individuals; however, the risk among the elderly, especially the very elderly, is not w...

    Authors: Toshio Hayashi, Atsushi Araki, Seinosuke Kawashima, Hirohito Sone, Hiroshi Watanabe, Takashi Ohrui, Koutaro Yokote, Minoru Takemoto, Kiyoshi Kubota, Mitsuhiko Noda, Hiroshi Noto, Koichiro Ina and Hideki Nomura
    Citation: Cardiovascular Diabetology 2013 12:10
    Content type: Original investigation Published on:

  3. Postprandial hyperlipidemia impairs endothelial function and participates in the development of atherosclerosis. We investigated the postprandial effects of a dipeptidyl peptidase IV inhibitor, alogliptin, on ...

    Authors: Yoko Noda, Toru Miyoshi, Hiroki Oe, Yuko Ohno, Kazufumi Nakamura, Norihisa Toh, Kunihisa Kohno, Hiroshi Morita, Kengo Kusano and Hiroshi Ito
    Citation: Cardiovascular Diabetology 2013 12:8
    Content type: Original investigation Published on:

  4. Vitamin K has been related to glucose metabolism, insulin sensitivity and diabetes. Because inflammation underlies all these metabolic conditions, it is plausible that the potential role of vitamin K in glucos...

    Authors: Martí Juanola-Falgarona, Jordi Salas-Salvadó, Ramon Estruch, Maria P Portillo, Rosa Casas, Jonatan Miranda, Miguel A Martínez-González and Mònica Bulló
    Citation: Cardiovascular Diabetology 2013 12:7
    Content type: Original investigation Published on:

  5. Fibulin-1 is one of a few extracellular matrix proteins present in blood in high concentrations. We aimed to define the relationship between plasma fibulin-1 levels and risk markers of cardiovascular disease.

    Authors: Alexandra Scholze, Else-Marie Bladbjerg, Johannes J Sidelmann, Axel CP Diederichsen, Hans Mickley, Mads Nybo, W Scott Argraves, Peter Marckmann and Lars M Rasmussen
    Citation: Cardiovascular Diabetology 2013 12:6
    Content type: Original investigation Published on:

  6. The Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome (JAPAN-ACS) trial demonstrated that early aggressive statin therapy in patients with ACS significantly reduces plaque volume (PV...

    Authors: Yoshifumi Fukushima, Hiroyuki Daida, Takeshi Morimoto, Takatoshi Kasai, Katsumi Miyauchi, Sho-ichi Yamagishi, Masayoshi Takeuchi, Takafumi Hiro, Takeshi Kimura, Yoshihisa Nakagawa, Masakazu Yamagishi, Yukio Ozaki and Masunori Matsuzaki
    Citation: Cardiovascular Diabetology 2013 12:5
    Content type: Original investigation Published on:

  7. Although a decrease in serum potassium level has been suggested to be a fairly common observation in acute coronary syndrome (ACS), there have so far been no definitive reports directly demonstrating the trans...

    Authors: Hiroshi Sekiyama, Tomohisa Nagoshi, Kimiaki Komukai, Masato Matsushima, Daisuke Katoh, Kazuo Ogawa, Kosuke Minai, Takayuki Ogawa and Michihiro Yoshimura
    Citation: Cardiovascular Diabetology 2013 12:4
    Content type: Original investigation Published on:

  8. To compare the incidence of cardiovascular events and mortality in patients with type 2 diabetes mellitus treated with sitagliptin or non-sitagliptin comparators.

    Authors: Samuel S Engel, Gregory T Golm, Deborah Shapiro, Michael J Davies, Keith D Kaufman and Barry J Goldstein
    Citation: Cardiovascular Diabetology 2013 12:3
    Content type: Original investigation Published on:

  10. Fluctuations in blood glucose level cause endothelial dysfunction and play a critical role in onset and/or progression of atherosclerosis. We hypothesized that fluctuation in blood glucose levels correlate wit...

    Authors: Keiichi Torimoto, Yosuke Okada, Hiroko Mori and Yoshiya Tanaka
    Citation: Cardiovascular Diabetology 2013 12:1
    Content type: Original investigation Published on:

  11. Cardiovascular risk factors (CVRF) may cluster in type 1 diabetes, analogously to the metabolic syndrome described in type 2 diabetes. The threshold of HbA1c above which lipid variables start changing behavior is...

    Authors: Fernando MA Giuffrida, Alexis D Guedes, Eloa R Rocco, Denise B Mory, Patricia Dualib, Odelisa S Matos, Reine M Chaves-Fonseca, Roberta A Cobas, Carlos Antonio Negrato, Marilia B Gomes and Sergio A Dib
    Citation: Cardiovascular Diabetology 2012 11:156
    Content type: Original investigation Published on:

  12. The appropriateness of the routine performance of an oral glucose tolerance test (OGTT) to screen for diabetes mellitus (DM) during acute coronary syndrome hospitalization is still under debate.

    Authors: Yicong Ye, Hongzhi Xie, Xiliang Zhao and Shuyang Zhang
    Citation: Cardiovascular Diabetology 2012 11:155
    Content type: Original investigation Published on:

  13. Elevation of cardiac troponin has been documented in multiple settings without acute coronary syndrome. However, its impact on long-term cardiac outcomes in the context of acute decompensated diabetes remains ...

    Authors: Anthony Eubanks, Farhan Raza, Mohamad Alkhouli, April N Glenn, Carol Homko, Abul Kashem and Alfred Bove
    Citation: Cardiovascular Diabetology 2012 11:154
    Content type: Original investigation Published on:

  14. In diabetes, a variety of pro-inflammatory cellular changes has been found in various cell types, including monocytes which are known to be involved in all the phases of atherogenesis. Angiotensin II (Ang II) ...

    Authors: Franca Marino, Andrea Maria Maresca, Marco Cosentino, Luana Castiglioni, Emanuela Rasini, Christian Mongiardi, Ramona C Maio, Massimiliano Legnaro, Laura Schembri, Francesco Dentali, Anna Maria Grandi and Luigina Guasti
    Citation: Cardiovascular Diabetology 2012 11:153
    Content type: Original investigation Published on:

  15. Diabetic patients experience stimulated coagulation and dysfibrinolysis, which is associated with an increased risk of cardiovascular events. This imbalance may precede the manifest diagnosis. We investigated ...

    Authors: Jenny Hernestål-Boman, Margareta Norberg, Jan-Hakan Jansson, Mats Eliasson, Jan W Eriksson, Bernt Lindahl and Lars Johansson
    Citation: Cardiovascular Diabetology 2012 11:152
    Content type: Original investigation Published on:

  16. Several peptides, named adipokines, are produced by the adipose tissue. Among those, adiponectin (AD) is the most abundant. AD promotes peripheral insulin sensitivity, inhibits liver gluconeogenesis and displa...

    Authors: Samuele Baldasseroni, Alessandro Antenore, Claudia Di Serio, Francesco Orso, Giuseppe Lonetto, Nadia Bartoli, Alice Foschini, Andrea Marella, Alessandra Pratesi, Salvatore Scarantino, Stefano Fumagalli, Matteo Monami, Edoardo Mannucci, Niccolò Marchionni and Francesca Tarantini
    Citation: Cardiovascular Diabetology 2012 11:151
    Content type: Original investigation Published on:

  17. Neointimal formation plays an important role in the pathogenesis of coronary restenosis after percutaneous coronary intervention (PCI), especially in patients with diabetes mellitus. Recently, some studies hav...

    Authors: Jingsheng Guo, Dongye Li, Shiru Bai, Tongda Xu, Zhongmin Zhou and Yanbin Zhang
    Citation: Cardiovascular Diabetology 2012 11:150
    Content type: Study protocol Published on:

  18. Low concentrations of plasma vitamin D (25(OH)D) have been associated with the development of metabolic syndrome (MetS), obesity, diabetes and cardiovascular disease. The objective of this study was to quantif...

    Authors: Alba Guasch, Mònica Bulló, Antoni Rabassa, Anna Bonada, Daniel Del Castillo, Fàtima Sabench and Jordi Salas-Salvadó
    Citation: Cardiovascular Diabetology 2012 11:149
    Content type: Original investigation Published on:

  19. Patients with type 2 diabetes have 2–4 times greater risk for cardiovascular morbidity and mortality than those without, and this is even further aggravated if they also suffer from hypertension. Unfortunately...

    Authors: Anselm K Gitt, Roland E Schmieder, Eva Duetting, Peter Bramlage, Steffen Schneider and Diethelm Tschöpe
    Citation: Cardiovascular Diabetology 2012 11:148
    Content type: Study protocol Published on:

  20. Endothelial progenitor cells (EPCs) are responsible for angiogenesis and maintenance of microvascular integrity, the number of EPCs is correlated with oxidative stress. Their relation to myocardial dysfunction...

    Authors: Chun Ting Zhao, Mei Wang, Chung Wah Siu, Ying Long Hou, Tian Wang, Hung Fat Tse and Kai Hang Yiu
    Citation: Cardiovascular Diabetology 2012 11:147
    Content type: Original investigation Published on:

  21. The purpose of this study was to determine the sex-specific pattern of pediatric cardiometabolic risk with principal component analysis, using several biological, behavioral and parental variables in a large c...

    Authors: Mark D Peterson, Dongmei Liu, Heidi B IglayReger, William A Saltarelli, Paul S Visich and Paul M Gordon
    Citation: Cardiovascular Diabetology 2012 11:146
    Content type: Original investigation Published on:

  22. Patients with type 1 diabetes have a substantial risk of developing cardiovascular complications early in life. We aimed to explore the role of insulin sensitivity (Si) as an early factor of atherosclerosis in yo...

    Authors: Björn Rathsman, Stefan Rosfors, Åke Sjöholm and Thomas Nyström
    Citation: Cardiovascular Diabetology 2012 11:145
    Content type: Original investigation Published on:

  23. Endothelial dysfunction is a well documented evidence for the onset of atherosclerosis and other cardiovascular diseases. Lipids disorder is among the main risk factors for endothelial dysfunction in these dis...

    Authors: Dai Tian, Yanyan Qiu, Yongkun Zhan, Xiaobo Li, Xiuling Zhi, Xinhong Wang, Lianhua Yin and Yanxia Ning
    Citation: Cardiovascular Diabetology 2012 11:144
    Content type: Original investigation Published on:

  24. The role of systemic and myocardial adiponectin (ADN) in dilated cardiomyopathy is still debated. We tested the regulation of both systemic and myocardial ADN and the relationship with AMP-activated protein ki...

    Authors: Chiara Caselli, Vincenzo Lionetti, Manuela Cabiati, Tommaso Prescimone, Giovanni D Aquaro, Virginia Ottaviano, Fabio Bernini, Letizia Mattii, Silvia Del Ry and Daniela Giannessi
    Citation: Cardiovascular Diabetology 2012 11:143
    Content type: Original investigation Published on:

  25. To assess the efficacy and safety of adding liraglutide to established insulin therapy in poorly controlled Chinese subjects with type 2 diabetes and abdominal obesity compared with increasing insulin dose.

    Authors: Chun-jun Li, Jing Li, Qiu-mei Zhang, Lin Lv, Rui Chen, Chun-feng Lv, Pei Yu and De-min Yu
    Citation: Cardiovascular Diabetology 2012 11:142
    Content type: Original investigation Published on:

  26. Central arterial stiffness represents a well-established predictor of cardiovascular disease. Decreased circulating endothelial progenitor cells (EPCs), increased asymmetric dimethyl-arginine (ADMA) levels, tr...

    Authors: Ioannis Protopsaltis, Stefanos Foussas, Angeliki Angelidi, Angelos Gritzapis, Theodoros Ν Sergentanis, Spyros Matsagos, Konstantinos Tzirogiannis, Georgios I Panoutsopoulos, Georgios Dimitriadis, Sotirios Raptis and Andreas Melidonis
    Citation: Cardiovascular Diabetology 2012 11:141
    Content type: Original investigation Published on:

  27. All fibrates are peroxisome proliferators-activated receptors (PPARs)-alpha agonists with ability to decrease triglyceride and increase high density lipoprotein- cholesterol (HDL-C). However, bezafibrate has a...

    Authors: Alexander Tenenbaum and Enrique Z Fisman
    Citation: Cardiovascular Diabetology 2012 11:140
    Content type: Review Published on:

  28. Telmisartan is a well-established angiotensin II type 1 receptor blocker that improves insulin sensitivity in animal models of obesity and insulin resistance, as well as in humans. Telmisartan has been reporte...

    Authors: Asuka Shiota, Michio Shimabukuro, Daiju Fukuda, Takeshi Soeki, Hiromi Sato, Etsuko Uematsu, Yoichiro Hirata, Hirotsugu Kurobe, Norikazu Maeda, Hiroshi Sakaue, Hiroaki Masuzaki, Iichiro Shimomura and Masataka Sata
    Citation: Cardiovascular Diabetology 2012 11:139
    Content type: Original investigation Published on:

  29. The genomic region at 9p21 chromosome near the CDKN2A/CDKN2B genes is associated with type 2 diabetes(T2D) and cardiovascular disease(CVD). The effect of the 9p21 locus on long-term mortality in patients with T2D...

    Authors: Gijs WD Landman, Jana V van Vliet-Ostaptchouk, Nanne Kleefstra, Kornelis JJ van Hateren, Iefke Drion, Klaas H Groenier, Rijk OB Gans, Harold Snieder, Marten H Hofker and Henk JG Bilo
    Citation: Cardiovascular Diabetology 2012 11:138
    Content type: Original investigation Published on:

  30. Although the Fat Mass and Obesity (FTO) and Melanocortin-4 Receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still...

    Authors: Carolina Ortega-Azorín, Jose V Sorlí, Eva M Asensio, Oscar Coltell, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Maria-Isabel Covas, Fernando Arós, José Lapetra, Lluís Serra-Majem, Enrique Gómez-Gracia, Miquel Fiol, Guillermo Sáez-Tormo, Xavier Pintó, Miguel Angel Muñoz, Emilio Ros…
    Citation: Cardiovascular Diabetology 2012 11:137
    Content type: Original investigation Published on:

  32. It has been reported previously that diabetic cardiomyopathy can be inhibited or reverted with chronic zinc supplementation. In the current study, we hypothesized that total cardiac calcium and zinc content is...

    Authors: Ting Yi, Yaser Cheema, Sarah M Tremble, Stephen P Bell, Zengyi Chen, Meenakumari Subramanian, Martin M LeWinter, Peter VanBuren and Bradley M Palmer
    Citation: Cardiovascular Diabetology 2012 11:135
    Content type: Original investigation Published on:

  33. Patients with hypertension and cardiovascular disease (CVD), diabetes, or chronic kidney disease (CKD) usually require two or more antihypertensive agents to achieve blood pressure (BP) goals.

    Authors: Dean J Kereiakes, Steven G Chrysant, Joseph L Izzo Jr, Thomas Littlejohn III, Michael Melino, James Lee, Victor Fernandez and Reinilde Heyrman
    Citation: Cardiovascular Diabetology 2012 11:134
    Content type: Original investigation Published on:

  34. Mechanisms involved in metabolic syndrome (MetS) development include insulin resistance, weight regulation, inflammation and lipid metabolism. Aim of this study is to investigate the association of single nucl...

    Authors: Cécile M Povel, Jolanda MA Boer, N Charlotte Onland-Moret, Martijn ET Dollé, Edith JM Feskens and Yvonne T van der Schouw
    Citation: Cardiovascular Diabetology 2012 11:133
    Content type: Original investigation Published on:

  36. Estimated glomerular filtration rate (eGFR) is a powerful predictor of mortality in diabetic patients with limited proteinuria data. In this study, we tested whether concomitant proteinuria increases the risk ...

    Authors: Cheng-Chieh Lin, Ching-Chu Chen, Pei-Tseng Kung, Chia-Ing Li, Sing-Yu Yang, Chiu-Shong Liu, Wen-Yuan Lin, Cheng-Chun Lee, Tsai-Chung Li and Sharon LR Kardia
    Citation: Cardiovascular Diabetology 2012 11:131
    Content type: Original investigation Published on:

  37. Sex hormone-binding globulin (SHBG) levels and sex hormones have been implicated in the pathogenesis of type 2 diabetes and cardiovascular diseases. As fatty liver has been suggested to be a major determinant ...

    Authors: Atsushi Goto, Akemi Morita, Maki Goto, Satoshi Sasaki, Motohiko Miyachi, Naomi Aiba, Yasuo Terauchi, Mitsuhiko Noda and Shaw Watanabe
    Citation: Cardiovascular Diabetology 2012 11:130
    Content type: Original investigation Published on:

  38. The aim of this study was to investigate whether obestatin (OB), a peptide mediator encoded by the ghrelin gene exerting a protective effect in ischemic reperfused heart, is able to reduce cardiac dysfunctions...

    Authors: Manuela Aragno, Raffaella Mastrocola, Corrado Ghé, Elisa Arnoletti, Eleonora Bassino, Giuseppe Alloatti and Giampiero Muccioli
    Citation: Cardiovascular Diabetology 2012 11:129
    Content type: Original investigation Published on:

  39. The metabolic syndrome (MetS) is a cluster of clinical indices that signals increased risk for cardiovascular disease and Type 2 diabetes. The diagnosis of MetS is typically based on cut-off points for various...

    Authors: Matthew J Gurka, Christa L Ice, Shumei S Sun and Mark D DeBoer
    Citation: Cardiovascular Diabetology 2012 11:128
    Content type: Methodology Published on:

  40. Type 2 diabetes mellitus (T2DM) is independently associated with an increased risk for cardiovascular diseases that is primarily due to the early development of advanced atherosclerotic vascular changes. The a...

    Authors: Katerina K Naka, Katerina Papathanassiou, Aris Bechlioulis, Nikolaos Kazakos, Konstantinos Pappas, Stelios Tigas, Dimitrios Makriyiannis, Agathocles Tsatsoulis and Lampros K Michalis
    Citation: Cardiovascular Diabetology 2012 11:127
    Content type: Original investigation Published on:

  41. There is overwhelming evidence that dietary supplementation with n-3 polyunsaturated fatty acids (PUFAs), mainly EPA (C20:5n-3) and DHA (C22:6n-3), has cardiovascular protective effects on patients with type 2...

    Authors: Lianguo Hou, Kaoqi Lian, Min Yao, Yun Shi, Xin Lu, Lijia Fang, Tianbo He and Lingling Jiang
    Citation: Cardiovascular Diabetology 2012 11:126
    Content type: Original investigation Published on:

  42. Currently the world faces epidemic of several closely related conditions: obesity, metabolic syndrome and type 2 diabetes (T2DM). The lipid profile of these patients and those with metabolic syndrome is charac...

    Authors: Alexander Tenenbaum and Enrique Z Fisman
    Citation: Cardiovascular Diabetology 2012 11:125
    Content type: Review Published on:

  43. In patients with type 1 diabetes mellitus (T1DM), cardiovascular events are more common, and the outcome following a myocardial infarction is worse than in nondiabetic subjects. Ischemic or pharmacological pre...

    Authors: Richard Engbersen, Niels P Riksen, Marc J Mol, Bert Bravenboer, Otto C Boerman, Patrick Meijer, Wim JG Oyen, Cees Tack, Gerard A Rongen and Paul Smits
    Citation: Cardiovascular Diabetology 2012 11:124
    Content type: Original investigation Published on:

  44. Information about the interactions of single nucleotide polymorphisms (SNPs) and overweight/obesity on serum lipid profiles is still scarce. The present study was undertaken to detect ten SNPs and their intera...

    Authors: Rui-Xing Yin, Dong-Feng Wu, Lin Miao, Lynn Htet Htet Aung, Xiao-Li Cao, Ting-Ting Yan, Xing-Jiang Long, Wan-Ying Liu, Lin Zhang and Meng Li
    Citation: Cardiovascular Diabetology 2012 11:123
    Content type: Original investigation Published on:

  45. We aimed at identifying variables predicting hypoglycemia in elderly type 2 diabetic patients and the relation to HbA1c values achieved.

    Authors: Peter Bramlage, Anselm K Gitt, Christiane Binz, Michael Krekler, Evelin Deeg and Diethelm Tschöpe
    Citation: Cardiovascular Diabetology 2012 11:122
    Content type: Original investigation Published on:

  46. Type 2 diabetes patients have a decreased health-related quality of life compared to healthy persons, especially regarding physical functioning and well-being. Health-related quality of life is even lower in t...

    Authors: Paulien R Wermeling, Kees J Gorter, Henk F van Stel and Guy EHM Rutten
    Citation: Cardiovascular Diabetology 2012 11:121
    Content type: Original investigation Published on:

  47. Hypertension and dyslipidemia are often insufficiently controlled in persons with type 2 diabetes (T2D) in Germany. In the current study we evaluated individual characteristics that are assumed to influence th...

    Authors: Ina-Maria Rückert, Werner Maier, Andreas Mielck, Sabine Schipf, Henry Völzke, Alexander Kluttig, Karin-Halina Greiser, Klaus Berger, Grit Müller, Ute Ellert, Hannelore Neuhauser, Wolfgang Rathmann, Teresa Tamayo, Susanne Moebus, Silke Andrich and Christa Meisinger
    Citation: Cardiovascular Diabetology 2012 11:120
    Content type: Original investigation Published on:

  48. Elevated plasma N-terminal (NT)-proBNP from the heart as well as white matter hyperintensities (WMH) in the brain predict cardiovascular (CV) mortality in the general population. The cause of poor prognosis as...

    Authors: Henrik Reinhard, Ellen Garde, Arnold Skimminge, Per Åkeson, Thomas Zoëga Ramsøy, Kaj Winther, Hans-Henrik Parving, Peter Rossing and Peter K Jacobsen
    Citation: Cardiovascular Diabetology 2012 11:119
    Content type: Original investigation Published on:

  49. Angiotensin receptor blockers (ARBs) are reported to provide direct protection to many organs by controlling inflammation and decreasing oxidant stress in patients without arteriosclerosis. This study aimed to...

    Authors: Masaya Sakamoto, Hirofumi Suzuki, Takeshi Hayashi, Hiroyuki Iuchi, Tsuyoshi Isaka, Noriko Sakamoto, Yosuke Kayama, Katsuyoshi Tojo, Michihiro Yoshimura and Kazunori Utsunomiya
    Citation: Cardiovascular Diabetology 2012 11:118
    Content type: Original investigation Published on:

  50. The aim of the present study was to examine how liver markers are associated with insulin resistance in Japanese community-dwelling adults.

    Authors: Ryuichi Kawamoto, Katsuhiko Kohara, Tomo Kusunoki, Yasuharu Tabara, Masanori Abe and Tetsuro Miki
    Citation: Cardiovascular Diabetology 2012 11:117
    Content type: Original investigation Published on:
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ISSN: 1475-2840