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  1. Metabolic syndrome (MetS) is associated with increased risk of cardiovascular disease (CVD). One important feature underlying the pathophysiology of many types of CVD is microvascular dysfunction. Although com...

    Authors: Cristiane Aoqui, Stefan Chmielewski, Elias Scherer, Ruth Eißler, Daniel Sollinger, Irina Heid, Rickmer Braren, Christoph Schmaderer, Remco TA Megens, Christian Weber, Uwe Heemann, Matthias Tschöp and Marcus Baumann
    Citation: Cardiovascular Diabetology 2014 13:31
    Content type: Original investigation Published on:

  2. Azilsartan, an angiotensin II type 1 (AT1) receptor blocker (ARB), has a higher affinity for and slower dissociation from AT1 receptors and shows stronger inverse agonism compared to other ARBs. Possible benef...

    Authors: Sachiko Matsumoto, Michio Shimabukuro, Daiju Fukuda, Takeshi Soeki, Ken Yamakawa, Hiroaki Masuzaki and Masataka Sata
    Citation: Cardiovascular Diabetology 2014 13:30
    Content type: Original investigation Published on:

  4. The Editors of Cardiovascular Diabetology wish to thank all reviewers, both Editorial Board Members and external referees, who contributed to the journal in 2013 (Volume 12), and whose enthusiastic support in ...

    Authors: Alexander Tenenbaum and Enrique Fisman
    Citation: Cardiovascular Diabetology 2014 13:18
    Content type: Reviewer acknowledgement Published on:

  5. Individuals with type 1 diabetes mellitus are at high risk for the development of hypertension, contributing to cardiovascular complications. Hyperglycaemia-mediated neurohormonal activation increases arterial...

    Authors: David ZI Cherney, Bruce A Perkins, Nima Soleymanlou, Ronnie Har, Nora Fagan, Odd Erik Johansen, Hans-Juergen Woerle, Maximilian von Eynatten and Uli C Broedl
    Citation: Cardiovascular Diabetology 2014 13:28
    Content type: Original investigation Published on:

  6. AMP activated protein kinase (AMPK) regulates the coordination of anabolic and catabolic processes and is an attractive therapeutic target for T2DM, obesity and metabolic syndrome. We report the anti-hyperglyc...

    Authors: Tharappel M Anil, Chandrashekaran Harish, Mudigere N Lakshmi, KrishnaReddy Harsha, Mallappa Onkaramurthy, Venkatesh Sathish Kumar, Nitya Shree, Venkatachalaiah Geetha, Gundalmandikal V Balamurali, Aralakuppe S Gopala, Bobbili Madhusudhan Reddy, Madabosse K Govind, Mammen O Anup, Yoganand Moolemath, Marikunte V Venkataranganna, Madanahalli R Jagannath…
    Citation: Cardiovascular Diabetology 2014 13:27
    Content type: Original investigation Published on:

  7. Cardiovascular disease poses a major challenge for the 21st century, exacerbated by the pandemics of obesity, metabolic syndrome and type 2 diabetes. While best standards of care, including high-dose statins, ...

    Authors: Jean-Charles Fruchart, Jean Davignon, Michel P Hermans, Khalid Al-Rubeaan, Pierre Amarenco, Gerd Assmann, Philip Barter, John Betteridge, Eric Bruckert, Ada Cuevas, Michel Farnier, Ele Ferrannini, Paola Fioretto, Jacques Genest, Henry N Ginsberg, Antonio M Gotto Jr…
    Citation: Cardiovascular Diabetology 2014 13:26
    Content type: Review Published on:

  8. The associations of metabolic syndrome (MetS) or diabetes mellitus (DM) on long-term survival after coronary artery bypass grafting (CABG) have not been extensively evaluated. The aim of the present study was ...

    Authors: Ville Hällberg, Ari Palomäki, Jorma Lahtela, Seppo Voutilainen, Matti Tarkka and Matti Kataja
    Citation: Cardiovascular Diabetology 2014 13:25
    Content type: Original investigation Published on:

  9. The liver-specific glucokinase knockout (gckw/–) mouse experiences long-term hyperglycemia and insulin resistance. This study was designed to evaluate the functional and structural changes in the myocardium of 60...

    Authors: Hui Li, Xi Wang, Yiqing Mao, Ruobi Hu, Wei Xu, Zhen Lei, Na Zhou, Ling Jin, Tingting Guo, Zhixin Li, David M Irwin, Gang Niu and Huanran Tan
    Citation: Cardiovascular Diabetology 2014 13:24
    Content type: Original investigation Published on:

  10. Obesity and particularly the metabolic syndrome, which is often associated with obesity, combine a major risk for type 2 diabetes and cardiovascular disease. Emerging evidence indicate obesity-associated subcl...

    Authors: Angelika Neuhofer, Bernhard Wernly, Lukas Leitner, Alisina Sarabi, Nicole G Sommer, Günther Staffler, Maximilian Zeyda and Thomas M Stulnig
    Citation: Cardiovascular Diabetology 2014 13:23
    Content type: Methodology Published on:

  11. Early menarche has been linked to higher risk of type 2 diabetes in Western and Asian societies, yet whether age at menarche is associated with diabetes in Latin America, where puberty and diabetes may have di...

    Authors: Noel T Mueller, Bruce B Duncan, Sandhi M Barreto, Dora Chor, Marina Bessel, Estela ML Aquino, Mark A Pereira and Maria Inês Schmidt
    Citation: Cardiovascular Diabetology 2014 13:22
    Content type: Original investigation Published on:

  12. An impaired endothelial function has been recognized in the early stage of atherosclerosis, and is a major factor affecting the future development of cardiovascular events. Type 2 diabetes mellitus (T2DM) is w...

    Authors: Jun-ichi Oyama, Yukihito Higashi and Koichi Node
    Citation: Cardiovascular Diabetology 2014 13:21
    Content type: Review Published on:

  13. To investigate whether flow-mediated dilation (FMD) impairment, which precedes overt atherosclerosis, is associated with silent myocardial ischemia (SMI) and asymptomatic coronary artery disease (CAD) in type ...

    Authors: Minh Tuan Nguyen, Isabelle Pham, Paul Valensi, Hélène Rousseau, Eric Vicaut, Christelle Laguillier-Morizot, Alain Nitenberg and Emmanuel Cosson
    Citation: Cardiovascular Diabetology 2014 13:20
    Content type: Original investigation Published on:

  14. Patients with diabetes mellitus are at increased risk for microvascular complications. Early changes in microcirculation are characterized by hyperperfusion (e.g. in the retina and kidney) and increased pulse ...

    Authors: Christian Ott, Ulrike Raff, Stephanie Schmidt, Iris Kistner, Stefanie Friedrich, Peter Bramlage, Joanna M Harazny and Roland E Schmieder
    Citation: Cardiovascular Diabetology 2014 13:19
    Content type: Original investigation Published on:

  15. High density lipoproteins (HDL) have many cardioprotective roles; however, in subjects with type 2 diabetes (T2D) these cardioprotective properties are diminished. Conversely, increased fruit and vegetable (F&...

    Authors: Jane-Ann Daniels, Ciara Mulligan, David McCance, Jayne V Woodside, Christopher Patterson, Ian S Young and Jane McEneny
    Citation: Cardiovascular Diabetology 2014 13:16
    Content type: Original investigation Published on:

  16. The purpose of this study was to elucidate the effects of glimepiride on the levels of biomarkers related to cardiovascular regulation in patients with type 2 diabetes mellitus.

    Authors: Ikuko Nakamura, Jun-ichi Oyama, Hiroshi Komoda, Aya Shiraki, Yoshiko Sakamoto, Isao Taguchi, Atsushi Hiwatashi, Aiko Komatsu, Masayoshi Takeuchi, Sho-ichi Yamagishi, Teruo Inoue and Koichi Node
    Citation: Cardiovascular Diabetology 2014 13:15
    Content type: Original investigation Published on:

  17. C1q/TNF-related protein-3 (CTRP-3), an adiponectin paralog, and progranulin were recently identified as novel adipokines which may link obesity with glucose dysregulation and subclinical inflammation. We analy...

    Authors: Kyung Mook Choi, Soon Young Hwang, Ho Chel Hong, Hae Yoon Choi, Hye Jin Yoo, Byung-Soo Youn, Sei Hyun Baik and Hong Seog Seo
    Citation: Cardiovascular Diabetology 2014 13:14
    Content type: Original investigation Published on:

  18. Diabetes mellitus (DM) accelerates plaque progression despite the use of statin therapy. The purpose of the present study was to evaluate the determinants of atheroma progression in statin-treated patients wit...

    Authors: Tsuyoshi Nozue, Shingo Yamamoto, Shinichi Tohyama, Kazuki Fukui, Shigeo Umezawa, Yuko Onishi, Tomoyuki Kunishima, Akira Sato, Toshihiro Nozato, Shogo Miyake, Youichi Takeyama, Yoshihiro Morino, Takao Yamauchi, Toshiya Muramatsu, Kiyoshi Hibi, Mitsuyasu Terashima…
    Citation: Cardiovascular Diabetology 2014 13:13
    Content type: Original investigation Published on:

  19. Coronary heart disease and type-2 diabetes are both major global health burdens associated with an increased risk of myocardial infarction (MI). Following MI, ischaemia-reperfusion injury (IRI) remains a signi...

    Authors: Sophie J Clarke, Liam M McCormick and David P Dutka
    Citation: Cardiovascular Diabetology 2014 13:12
    Content type: Review Published on:

  20. Cardiomyopathy and distal symmetrical polyneuropathy (DSPN), including sensory and autonomic dysfunction, often co-occur in diabetic mellitus (DM) patients. However, the temporal relationship and progression b...

    Authors: Maria N Marangoni, Scott T Brady, Shamim A Chowdhury and Mariann R Piano
    Citation: Cardiovascular Diabetology 2014 13:11
    Content type: Original investigation Published on:

  21. The adipocyte-derived hormone leptin plays a key role in the regulation of appetite and body weight. Recent studies have suggested that leptin is also involved in the pathogenesis of obesity-related atheroscle...

    Authors: Tomoaki Morioka, Masanori Emoto, Yuko Yamazaki, Naoya Kawano, Satoshi Imamura, Ryutaro Numaguchi, Hiromi Urata, Koka Motoyama, Katsuhito Mori, Shinya Fukumoto, Hidenori Koyama, Tetsuo Shoji and Masaaki Inaba
    Citation: Cardiovascular Diabetology 2014 13:10
    Content type: Original investigation Published on:

  22. The complement system is part of the immune system in acute coronary syndrome (ACS). Adiponectin has anti-atherogenic and anti-inflammatory properties. Adiponectin and C1q form a protein complex in blood, and ...

    Authors: Ken Kishida, Yasuhiko Nakagawa, Hironori Kobayashi, Toru Mazaki, Hiroyoshi Yokoi, Koji Yanagi, Tohru Funahashi and Iichiro Shimomura
    Citation: Cardiovascular Diabetology 2014 13:9
    Content type: Original investigation Published on:

  23. High blood and tissue concentrations of glucose and advanced glycation end-products are believed to play an important role in the development of vascular complications in patients with diabetes mellitus (DM) a...

    Authors: Tali Zitman-Gal, Janice Green, Metsada Pasmanik-Chor, Eliezer Golan, Jacques Bernheim and Sydney Benchetrit
    Citation: Cardiovascular Diabetology 2014 13:8
    Content type: Original investigation Published on:

  24. With increasing numbers of type 2 diabetes (DM2) and hypertension patients, there is a pressing need for effective, time-efficient and sustainable strategies to help physicians support their patients to achiev...

    Authors: Kaberi Dasgupta, Ellen Rosenberg and Stella S Daskalopoulou
    Citation: Cardiovascular Diabetology 2014 13:7
    Content type: Study protocol Published on:

  25. Type 2 diabetes mellitus (T2DM) is often associated with atherosclerotic changes in coronary vessels, most notably plaques. The angiostatic parameter endostatin is able to inhibit angiogenesis in tissue as wel...

    Authors: Michael Sponder, Daniela Dangl, Stephanie Kampf, Monika Fritzer-Szekeres and Jeanette Strametz-Juranek
    Citation: Cardiovascular Diabetology 2014 13:6
    Content type: Original investigation Published on:

  26. The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G > A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related ...

    Authors: Dolores Corella, Jose V Sorlí, José I González, Carolina Ortega, Montserrat Fitó, Monica Bulló, Miguel Angel Martínez-González, Emilio Ros, Fernando Arós, José Lapetra, Enrique Gómez-Gracia, Lluís Serra-Majem, Valentina Ruiz-Gutierrez, Miquel Fiol, Oscar Coltell, Ernest Vinyoles…
    Citation: Cardiovascular Diabetology 2014 13:5
    Content type: Original investigation Published on:

  27. Diabetes is known to alter the energy metabolism of the heart. Thus, it may be expected to affect the efficiency of contraction (i.e., the ratio of mechanical work output to metabolic energy input). The litera...

    Authors: June-Chiew Han, Soyeon Goo, Carolyn J Barrett, Kimberley M Mellor, Andrew J Taberner and Denis S Loiselle
    Citation: Cardiovascular Diabetology 2014 13:4
    Content type: Original investigation Published on:

  28. Diabetes is associated with a high risk of death due to coronary artery disease (CAD). People with diabetes suffering from CAD are frequently treated with revascularization procedures. We aim to compare trends...

    Authors: Ana Lopez-de-Andres, Rodrigo Jimenez-García, Valentin Hernandez-Barrera, Napoleon Perez-Farinos, Jose M de Miguel-Yanes, Manuel Mendez-Bailon, Isabel Jimenez-Trujillo, Angel Gil de Miguel, Carmen Gallardo Pino and Pilar Carrasco-Garrido
    Citation: Cardiovascular Diabetology 2014 13:3
    Content type: Original investigation Published on:

  29. Obesity is associated with increased risk for stroke. The breath-holding index (BHI) is a measure of vasomotor reactivity of the brain which can be measured with the transcranial Doppler (TCD). We aim to evalu...

    Authors: Marcela Rodríguez-Flores, Eduardo García-García, Claudia Vanessa Cano-Nigenda and Carlos Cantú-Brito
    Citation: Cardiovascular Diabetology 2014 13:2
    Content type: Original investigation Published on:

  30. The role played by T helper cytokines under chronic, low grade inflammation as seen in type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) co-morbidity is less well studied. In the present study,...

    Authors: Haridoss Madhumitha, Viswanathan Mohan, Mohan Deepa, Subash Babu and Vivekanandhan Aravindhan
    Citation: Cardiovascular Diabetology 2014 13:1
    Content type: Original investigation Published on:

  31. An increased leukocyte count is an independent risk factor for cardiovascular events, but the association between leukocyte subtype counts and carotid atherosclerosis in patients with diabetes has not been det...

    Authors: Takeshi Matsumura, Kayo Taketa, Hiroyuki Motoshima, Takafumi Senokuchi, Norio Ishii, Hiroyuki Kinoshita, Kazuki Fukuda, Sarie Yamada, Daisuke Kukidome, Tatsuya Kondo, Aya Hisada, Takahiko Katoh, Seiya Shimoda, Takeshi Nishikawa and Eiichi Araki
    Citation: Cardiovascular Diabetology 2013 12:177
    Content type: Original investigation Published on:

  32. The lipocalin-2 (LCN2) cytokine, primarily known as a protein of the granules of human neutrophils, has been recently reported to be implicated in metabolic and inflammatory disorders. This study was designed ...

    Authors: Jie Ni, Xiaojing Ma, Mi Zhou, Xiaoping Pan, Junling Tang, Yaping Hao, Zhigang Lu, Meifang Gao, Yuqian Bao and Weiping Jia
    Citation: Cardiovascular Diabetology 2013 12:176
    Content type: Original investigation Published on:

  33. The anti-diabetic drug metformin has been demonstrated to exert a protective effect against vascular complications in diabetes independent of its glucose lowering action. Since the endothelial glycocalyx has b...

    Authors: Bart JM Eskens, Coert J Zuurbier, Judith van Haare, Hans Vink and Jurgen WGE van Teeffelen
    Citation: Cardiovascular Diabetology 2013 12:175
    Content type: Original investigation Published on:

  34. Previous studies suggested an impaired endothelial function in patients with diabetes. However, the validity of this finding may be limited by the lack of adequate adjustment for further cardiovascular confoun...

    Authors: Klaus Empen, Roberto Lorbeer, Henry Völzke, Thorsten Reffelmann, Sabine Schipf, Matthias Nauck, Wolfgang Kerner, Henri Wallaschofski, Stephan B Felix and Marcus Dörr
    Citation: Cardiovascular Diabetology 2013 12:174
    Content type: Original investigation Published on:

  35. Atherosclerosis is a major health burden. Metabolic disorders had been associated with large consumption of soft drinks. The rising incidence of atherosclerosis and metabolic alterations warrants the study of ...

    Authors: Matilde E Otero-Losada, Santiago Mc Loughlin, Gastón Rodríguez-Granillo, Angélica Müller, Graciela Ottaviano, Marisa Moriondo, Juan C Cutrin and José Milei
    Citation: Cardiovascular Diabetology 2013 12:57
    Content type: Original investigation Published on:

  36. We have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult sub...

    Authors: Camila C Leança, Valéria S Nunes, Natália B Panzoldo, Vanessa S Zago, Eliane S Parra, Patrícia M Cazita, Matti Jauhiainen, Marisa Passarelli, Edna R Nakandakare, Eliana C de Faria and Eder CR Quintão
    Citation: Cardiovascular Diabetology 2013 12:173
    Content type: Original investigation Published on:

  37. Cardiac steatosis and apoptosis are key processes in diabetic cardiomyopathy, but the underlying mechanisms have not been elucidated, leading to a lack of effective therapy. The mineralocorticoid receptor bloc...

    Authors: Elisa Ramírez, Mercedes Klett-Mingo, Sara Ares-Carrasco, Belén Picatoste, Alessia Ferrarini, Francisco J Rupérez, Alicia Caro-Vadillo, Coral Barbas, Jesús Egido, José Tuñón and Óscar Lorenzo
    Citation: Cardiovascular Diabetology 2013 12:172
    Content type: Original investigation Published on:

  38. The presence of diabetes and plasma glucose concentration on admission are associated with adverse outcomes after an acute myocardial infarction (AMI), as high glucose can induce vascular endothelial cell apop...

    Authors: Jing Chang, Gong Zhang, Li Zhang, Yuan-Ping Hou, Xiu-Lan Liu and Lin Zhang
    Citation: Cardiovascular Diabetology 2013 12:171
    Content type: Original investigation Published on:

  39. Ethnic-specific differences in insulin resistance (IR) are well described but the underlying mechanisms are unknown. Adiponectin is an insulin sensitizing adipocytokine that circulates as multiple isoforms, wi...

    Authors: Dian C Sulistyoningrum, Danijela Gasevic, Scott A Lear, Joe Ho, Andrew Mente and Angela M Devlin
    Citation: Cardiovascular Diabetology 2013 12:170
    Content type: Original investigation Published on:

  40. Diabetes-induced organ damage is significantly associated with the activation of the renin-angiotensin system (RAS). Recently, several studies have demonstrated a change in the RAS from an extracellular to an ...

    Authors: Qian Chen Yong, Candice M Thomas, Rachid Seqqat, Niketa Chandel, Kenneth M Baker and Rajesh Kumar
    Citation: Cardiovascular Diabetology 2013 12:169
    Content type: Original investigation Published on:

  41. Elevated plasma preprovasopressin (copeptin) levels are associated with cardiovascular complications as well as with an increased risk for type 2 diabetes (T2D). Here, we studied, whether plasma copeptin is re...

    Authors: Cornelia Then, Bernd Kowall, Andreas Lechner, Christa Meisinger, Margit Heier, Wolfgang Koenig, Annette Peters, Joachim Thiery, Wolfgang Rathmann and Jochen Seissler
    Citation: Cardiovascular Diabetology 2013 12:168
    Content type: Original investigation Published on:

  42. Long pentraxin 3 (PTX3) is a component of the pentraxin superfamily and a potential marker of vascular damage and inflammation, associated with negative outcome in patients with acute coronary syndromes (ACS)....

    Authors: Rocco Barazzoni, Aneta Aleksova, Cosimo Carriere, Maria Rosa Cattin, Michela Zanetti, Pierandrea Vinci, Davide Stolfo, Gianfranco Guarnieri and Gianfranco Sinagra
    Citation: Cardiovascular Diabetology 2013 12:167
    Content type: Original investigation Published on:

  43. Bilirubin has been implicated in cardiovascular protection by virtue of its anti-inflammatory and anti-oxidative properties. The metabolic syndrome is featured by enhanced low-grade systemic inflammation and o...

    Authors: Petronella E Deetman, Stephan JL Bakker and Robin PF Dullaart
    Citation: Cardiovascular Diabetology 2013 12:166
    Content type: Original investigation Published on:

  44. We investigated whether serum glycated albumin (GA) levels are related to coronary collateralization in type 2 diabetic patients with chronic total occlusion.

    Authors: Ying Shen, Lin Lu, Feng Hua Ding, Zhen Sun, Rui Yan Zhang, Qi Zhang, Zheng Kun Yang, Jian Hu, Qiu Jing Chen and Wei Feng Shen
    Citation: Cardiovascular Diabetology 2013 12:165
    Content type: Original investigation Published on:

  45. There is little information about predictive ability of haemoglobin A1c (HbA1c) for cardiovascular disease (CVD) in Asians. To investigate the discriminatory ability of HbA1c to identify subjects who are at gr...

    Authors: Fumie Ikeda, Yasufumi Doi, Toshiharu Ninomiya, Yoichiro Hirakawa, Naoko Mukai, Jun Hata, Kentaro Shikata, Daigo Yoshida, Takayuki Matsumoto, Takanari Kitazono and Yutaka Kiyohara
    Citation: Cardiovascular Diabetology 2013 12:164
    Content type: Original investigation Published on:

  46. There are numerous reports describing the efficacy of fenofibrate in combination with ezetimibe for treating dyslipidemia. In contrast, a study combining bezafibrate and ezetimibe has not yet been conducted. I...

    Authors: Tamio Teramoto, Kazunori Abe and Takehiko Taneyama
    Citation: Cardiovascular Diabetology 2013 12:163
    Content type: Original investigation Published on:

  47. We tested whether fatty liver, brachial-ankle pulse wave velocity (baPWV) and conventional cardiovascular risk factors were associated with a coronary artery calcium (CAC) score > 0 (as a marker of the presenc...

    Authors: Ki-Chul Sung, Young-Hyo Lim, Sungha Park, Seok-Min Kang, Jeong Bae Park, Byung-Jin Kim and Jin-Ho Shin
    Citation: Cardiovascular Diabetology 2013 12:162
    Content type: Original investigation Published on:

  48. Coronary artery calcification (CAC) is closely related to coronary atherosclerosis. However, less is known about the clinical significance of extensive CAC (ECAC) in regard to types of first coronary events (a...

    Authors: Joseph Shemesh, Alexander Tenenbaum, Enrique Z Fisman, Nira Koren-Morag and Ehud Grossman
    Citation: Cardiovascular Diabetology 2013 12:161
    Content type: Original investigation Published on:

  49. Dipeptidyl peptidase-4 (DPP-4) inhibitors modulate incretin hormones and exert anti-diabetic effects in type 2 diabetes mellitus. Treatment with angiotensin II type 1 receptor blockers (ARB) is a proven succes...

    Authors: Katsutoshi Miyagawa, Tatsuya Kondo, Rieko Goto, Rina Matsuyama, Kaoru Ono, Sayaka Kitano, Shuji Kawasaki, Motoyuki Igata, Junji Kawashima, Takeshi Matsumura, Hiroyuki Motoshima and Eiichi Araki
    Citation: Cardiovascular Diabetology 2013 12:160
    Content type: Original investigation Published on:

  50. Angiotensin II type 1 receptor blockers (ARB) are a frequently used class of antihypertensive drug. The ARB losartan is known to decrease the serum uric acid (SUA) level. However, there are very few clinical d...

    Authors: Yayoi Nishida, Yasuo Takahashi, Norio Susa, Nobukazu Kanou, Tomohiro Nakayama and Satoshi Asai
    Citation: Cardiovascular Diabetology 2013 12:159
    Content type: Original investigation Published on:
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Cardiovascular Diabetology

ISSN: 1475-2840