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  1. Patients with type 1 diabetes have a substantial risk of developing cardiovascular complications early in life. We aimed to explore the role of insulin sensitivity (Si) as an early factor of atherosclerosis in yo...

    Authors: Björn Rathsman, Stefan Rosfors, Åke Sjöholm and Thomas Nyström
    Citation: Cardiovascular Diabetology 2012 11:145
    Content type: Original investigation Published on:

  2. Endothelial dysfunction is a well documented evidence for the onset of atherosclerosis and other cardiovascular diseases. Lipids disorder is among the main risk factors for endothelial dysfunction in these dis...

    Authors: Dai Tian, Yanyan Qiu, Yongkun Zhan, Xiaobo Li, Xiuling Zhi, Xinhong Wang, Lianhua Yin and Yanxia Ning
    Citation: Cardiovascular Diabetology 2012 11:144
    Content type: Original investigation Published on:

  3. The role of systemic and myocardial adiponectin (ADN) in dilated cardiomyopathy is still debated. We tested the regulation of both systemic and myocardial ADN and the relationship with AMP-activated protein ki...

    Authors: Chiara Caselli, Vincenzo Lionetti, Manuela Cabiati, Tommaso Prescimone, Giovanni D Aquaro, Virginia Ottaviano, Fabio Bernini, Letizia Mattii, Silvia Del Ry and Daniela Giannessi
    Citation: Cardiovascular Diabetology 2012 11:143
    Content type: Original investigation Published on:

  4. To assess the efficacy and safety of adding liraglutide to established insulin therapy in poorly controlled Chinese subjects with type 2 diabetes and abdominal obesity compared with increasing insulin dose.

    Authors: Chun-jun Li, Jing Li, Qiu-mei Zhang, Lin Lv, Rui Chen, Chun-feng Lv, Pei Yu and De-min Yu
    Citation: Cardiovascular Diabetology 2012 11:142
    Content type: Original investigation Published on:

  5. Central arterial stiffness represents a well-established predictor of cardiovascular disease. Decreased circulating endothelial progenitor cells (EPCs), increased asymmetric dimethyl-arginine (ADMA) levels, tr...

    Authors: Ioannis Protopsaltis, Stefanos Foussas, Angeliki Angelidi, Angelos Gritzapis, Theodoros Ν Sergentanis, Spyros Matsagos, Konstantinos Tzirogiannis, Georgios I Panoutsopoulos, Georgios Dimitriadis, Sotirios Raptis and Andreas Melidonis
    Citation: Cardiovascular Diabetology 2012 11:141
    Content type: Original investigation Published on:

  6. All fibrates are peroxisome proliferators-activated receptors (PPARs)-alpha agonists with ability to decrease triglyceride and increase high density lipoprotein- cholesterol (HDL-C). However, bezafibrate has a...

    Authors: Alexander Tenenbaum and Enrique Z Fisman
    Citation: Cardiovascular Diabetology 2012 11:140
    Content type: Review Published on:

  7. Telmisartan is a well-established angiotensin II type 1 receptor blocker that improves insulin sensitivity in animal models of obesity and insulin resistance, as well as in humans. Telmisartan has been reporte...

    Authors: Asuka Shiota, Michio Shimabukuro, Daiju Fukuda, Takeshi Soeki, Hiromi Sato, Etsuko Uematsu, Yoichiro Hirata, Hirotsugu Kurobe, Norikazu Maeda, Hiroshi Sakaue, Hiroaki Masuzaki, Iichiro Shimomura and Masataka Sata
    Citation: Cardiovascular Diabetology 2012 11:139
    Content type: Original investigation Published on:

  8. The genomic region at 9p21 chromosome near the CDKN2A/CDKN2B genes is associated with type 2 diabetes(T2D) and cardiovascular disease(CVD). The effect of the 9p21 locus on long-term mortality in patients with T2D...

    Authors: Gijs WD Landman, Jana V van Vliet-Ostaptchouk, Nanne Kleefstra, Kornelis JJ van Hateren, Iefke Drion, Klaas H Groenier, Rijk OB Gans, Harold Snieder, Marten H Hofker and Henk JG Bilo
    Citation: Cardiovascular Diabetology 2012 11:138
    Content type: Original investigation Published on:

  9. Although the Fat Mass and Obesity (FTO) and Melanocortin-4 Receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still...

    Authors: Carolina Ortega-Azorín, Jose V Sorlí, Eva M Asensio, Oscar Coltell, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Maria-Isabel Covas, Fernando Arós, José Lapetra, Lluís Serra-Majem, Enrique Gómez-Gracia, Miquel Fiol, Guillermo Sáez-Tormo, Xavier Pintó, Miguel Angel Muñoz, Emilio Ros…
    Citation: Cardiovascular Diabetology 2012 11:137
    Content type: Original investigation Published on:

  11. It has been reported previously that diabetic cardiomyopathy can be inhibited or reverted with chronic zinc supplementation. In the current study, we hypothesized that total cardiac calcium and zinc content is...

    Authors: Ting Yi, Yaser Cheema, Sarah M Tremble, Stephen P Bell, Zengyi Chen, Meenakumari Subramanian, Martin M LeWinter, Peter VanBuren and Bradley M Palmer
    Citation: Cardiovascular Diabetology 2012 11:135
    Content type: Original investigation Published on:

  12. Patients with hypertension and cardiovascular disease (CVD), diabetes, or chronic kidney disease (CKD) usually require two or more antihypertensive agents to achieve blood pressure (BP) goals.

    Authors: Dean J Kereiakes, Steven G Chrysant, Joseph L Izzo Jr, Thomas Littlejohn III, Michael Melino, James Lee, Victor Fernandez and Reinilde Heyrman
    Citation: Cardiovascular Diabetology 2012 11:134
    Content type: Original investigation Published on:

  13. Mechanisms involved in metabolic syndrome (MetS) development include insulin resistance, weight regulation, inflammation and lipid metabolism. Aim of this study is to investigate the association of single nucl...

    Authors: Cécile M Povel, Jolanda MA Boer, N Charlotte Onland-Moret, Martijn ET Dollé, Edith JM Feskens and Yvonne T van der Schouw
    Citation: Cardiovascular Diabetology 2012 11:133
    Content type: Original investigation Published on:

  15. Estimated glomerular filtration rate (eGFR) is a powerful predictor of mortality in diabetic patients with limited proteinuria data. In this study, we tested whether concomitant proteinuria increases the risk ...

    Authors: Cheng-Chieh Lin, Ching-Chu Chen, Pei-Tseng Kung, Chia-Ing Li, Sing-Yu Yang, Chiu-Shong Liu, Wen-Yuan Lin, Cheng-Chun Lee, Tsai-Chung Li and Sharon LR Kardia
    Citation: Cardiovascular Diabetology 2012 11:131
    Content type: Original investigation Published on:

  16. Sex hormone-binding globulin (SHBG) levels and sex hormones have been implicated in the pathogenesis of type 2 diabetes and cardiovascular diseases. As fatty liver has been suggested to be a major determinant ...

    Authors: Atsushi Goto, Akemi Morita, Maki Goto, Satoshi Sasaki, Motohiko Miyachi, Naomi Aiba, Yasuo Terauchi, Mitsuhiko Noda and Shaw Watanabe
    Citation: Cardiovascular Diabetology 2012 11:130
    Content type: Original investigation Published on:

  17. The aim of this study was to investigate whether obestatin (OB), a peptide mediator encoded by the ghrelin gene exerting a protective effect in ischemic reperfused heart, is able to reduce cardiac dysfunctions...

    Authors: Manuela Aragno, Raffaella Mastrocola, Corrado Ghé, Elisa Arnoletti, Eleonora Bassino, Giuseppe Alloatti and Giampiero Muccioli
    Citation: Cardiovascular Diabetology 2012 11:129
    Content type: Original investigation Published on:

  18. The metabolic syndrome (MetS) is a cluster of clinical indices that signals increased risk for cardiovascular disease and Type 2 diabetes. The diagnosis of MetS is typically based on cut-off points for various...

    Authors: Matthew J Gurka, Christa L Ice, Shumei S Sun and Mark D DeBoer
    Citation: Cardiovascular Diabetology 2012 11:128
    Content type: Methodology Published on:

  19. Type 2 diabetes mellitus (T2DM) is independently associated with an increased risk for cardiovascular diseases that is primarily due to the early development of advanced atherosclerotic vascular changes. The a...

    Authors: Katerina K Naka, Katerina Papathanassiou, Aris Bechlioulis, Nikolaos Kazakos, Konstantinos Pappas, Stelios Tigas, Dimitrios Makriyiannis, Agathocles Tsatsoulis and Lampros K Michalis
    Citation: Cardiovascular Diabetology 2012 11:127
    Content type: Original investigation Published on:

  20. There is overwhelming evidence that dietary supplementation with n-3 polyunsaturated fatty acids (PUFAs), mainly EPA (C20:5n-3) and DHA (C22:6n-3), has cardiovascular protective effects on patients with type 2...

    Authors: Lianguo Hou, Kaoqi Lian, Min Yao, Yun Shi, Xin Lu, Lijia Fang, Tianbo He and Lingling Jiang
    Citation: Cardiovascular Diabetology 2012 11:126
    Content type: Original investigation Published on:

  21. Currently the world faces epidemic of several closely related conditions: obesity, metabolic syndrome and type 2 diabetes (T2DM). The lipid profile of these patients and those with metabolic syndrome is charac...

    Authors: Alexander Tenenbaum and Enrique Z Fisman
    Citation: Cardiovascular Diabetology 2012 11:125
    Content type: Review Published on:

  22. In patients with type 1 diabetes mellitus (T1DM), cardiovascular events are more common, and the outcome following a myocardial infarction is worse than in nondiabetic subjects. Ischemic or pharmacological pre...

    Authors: Richard Engbersen, Niels P Riksen, Marc J Mol, Bert Bravenboer, Otto C Boerman, Patrick Meijer, Wim JG Oyen, Cees Tack, Gerard A Rongen and Paul Smits
    Citation: Cardiovascular Diabetology 2012 11:124
    Content type: Original investigation Published on:

  23. Information about the interactions of single nucleotide polymorphisms (SNPs) and overweight/obesity on serum lipid profiles is still scarce. The present study was undertaken to detect ten SNPs and their intera...

    Authors: Rui-Xing Yin, Dong-Feng Wu, Lin Miao, Lynn Htet Htet Aung, Xiao-Li Cao, Ting-Ting Yan, Xing-Jiang Long, Wan-Ying Liu, Lin Zhang and Meng Li
    Citation: Cardiovascular Diabetology 2012 11:123
    Content type: Original investigation Published on:

  24. We aimed at identifying variables predicting hypoglycemia in elderly type 2 diabetic patients and the relation to HbA1c values achieved.

    Authors: Peter Bramlage, Anselm K Gitt, Christiane Binz, Michael Krekler, Evelin Deeg and Diethelm Tschöpe
    Citation: Cardiovascular Diabetology 2012 11:122
    Content type: Original investigation Published on:

  25. Type 2 diabetes patients have a decreased health-related quality of life compared to healthy persons, especially regarding physical functioning and well-being. Health-related quality of life is even lower in t...

    Authors: Paulien R Wermeling, Kees J Gorter, Henk F van Stel and Guy EHM Rutten
    Citation: Cardiovascular Diabetology 2012 11:121
    Content type: Original investigation Published on:

  26. Hypertension and dyslipidemia are often insufficiently controlled in persons with type 2 diabetes (T2D) in Germany. In the current study we evaluated individual characteristics that are assumed to influence th...

    Authors: Ina-Maria Rückert, Werner Maier, Andreas Mielck, Sabine Schipf, Henry Völzke, Alexander Kluttig, Karin-Halina Greiser, Klaus Berger, Grit Müller, Ute Ellert, Hannelore Neuhauser, Wolfgang Rathmann, Teresa Tamayo, Susanne Moebus, Silke Andrich and Christa Meisinger
    Citation: Cardiovascular Diabetology 2012 11:120
    Content type: Original investigation Published on:

  27. Elevated plasma N-terminal (NT)-proBNP from the heart as well as white matter hyperintensities (WMH) in the brain predict cardiovascular (CV) mortality in the general population. The cause of poor prognosis as...

    Authors: Henrik Reinhard, Ellen Garde, Arnold Skimminge, Per Åkeson, Thomas Zoëga Ramsøy, Kaj Winther, Hans-Henrik Parving, Peter Rossing and Peter K Jacobsen
    Citation: Cardiovascular Diabetology 2012 11:119
    Content type: Original investigation Published on:

  28. Angiotensin receptor blockers (ARBs) are reported to provide direct protection to many organs by controlling inflammation and decreasing oxidant stress in patients without arteriosclerosis. This study aimed to...

    Authors: Masaya Sakamoto, Hirofumi Suzuki, Takeshi Hayashi, Hiroyuki Iuchi, Tsuyoshi Isaka, Noriko Sakamoto, Yosuke Kayama, Katsuyoshi Tojo, Michihiro Yoshimura and Kazunori Utsunomiya
    Citation: Cardiovascular Diabetology 2012 11:118
    Content type: Original investigation Published on:

  29. The aim of the present study was to examine how liver markers are associated with insulin resistance in Japanese community-dwelling adults.

    Authors: Ryuichi Kawamoto, Katsuhiko Kohara, Tomo Kusunoki, Yasuharu Tabara, Masanori Abe and Tetsuro Miki
    Citation: Cardiovascular Diabetology 2012 11:117
    Content type: Original investigation Published on:

  30. Increased ferritin concentrations are associated with metabolic syndrome (MetS). The association between ferritin as well as hemoglobin level and individual MetS components is unclear. Erythropoietin levels in...

    Authors: Päivi Hämäläinen, Juha Saltevo, Hannu Kautiainen, Pekka Mäntyselkä and Mauno Vanhala
    Citation: Cardiovascular Diabetology 2012 11:116
    Content type: Original investigation Published on:

  31. Visceral fat deposition and its associated atherogenic complications are mediated by glucocorticoids. Cardiac visceral fat comprises mediastinal adipose tissue (MAT) and epicardial adipose tissue (EAT), and MA...

    Authors: Fatmahan Atalar, Selcuk Gormez, Baris Caynak, Gokce Akan, Gamze Tanriverdi, Sema Bilgic-Gazioglu, Demet Gunay, Cihan Duran, Belhhan Akpinar, Ugur Ozbek, Ahmet Sevim Buyukdevrim and Zeliha Yazici
    Citation: Cardiovascular Diabetology 2012 11:115
    Content type: Original investigation Published on:

  32. Chronic arterial stiffness contributes to the negative health effects of obesity and insulin resistance, which include hypertension, stroke, and increased cardiovascular and all-cause mortality. Weight loss an...

    Authors: Timothy M Hughes, Andrew D Althouse, Nancy A Niemczyk, Marquis S Hawkins, Allison L Kuipers and Kim Sutton-Tyrrell
    Citation: Cardiovascular Diabetology 2012 11:114
    Content type: Original investigation Published on:

  33. Vascular calcification is one of the common complications in diabetes mellitus. Many studies have shown that high glucose (HG) caused cardiovascular calcification, but its underlying mechanism is not fully und...

    Authors: Rining Tang, Min Gao, Min Wu, Hong Liu, Xiaoliang Zhang and Bicheng Liu
    Citation: Cardiovascular Diabetology 2012 11:113
    Content type: Original investigation Published on:

  34. High normal values of urine albumin-to-creatinine ratio (UACR) have been reported to have predictive values for hypertension, incident stroke, and higher mortality in the general population. This study aimed t...

    Authors: Sun-Seog Kweon, Min-Ho Shin, Young-Hoon Lee, Jin-Su Choi, Hae-Sung Nam, Kyeong-Soo Park, Do-Hyung Kim and Seul-Ki Jeong
    Citation: Cardiovascular Diabetology 2012 11:112
    Content type: Original investigation Published on:

  35. Hyperglycemia leads to cardiac oxidative stress and an imbalance in glucose homeostasis. Diabetic cardiomyopathy is characterised by cardiac hypertrophy and fibrosis. However, the underlying mechanisms of diab...

    Authors: Jung Eun Lee, Chin-ok Yi, Byeong Tak Jeon, Hyun Joo Shin, Soo Kyoung Kim, Tae Sik Jung, Jun Young Choi and Gu Seob Roh
    Citation: Cardiovascular Diabetology 2012 11:111
    Content type: Original investigation Published on:

  36. Non-enzymatic glycation increases hemoglobin-oxygen affinity and reduces oxygen delivery to tissues by altering the structure and function of hemoglobin.

    Authors: Li Jin Pu, Ying Shen, Lin Lu, Rui Yan Zhang, Qi Zhang and Wei Feng Shen
    Citation: Cardiovascular Diabetology 2012 11:110
    Content type: Original investigation Published on:

  37. Few large-scale, real-world studies have assessed the relative associations of lipid fractions with diabetic microvascular events. The main objective of this study was to evaluate the association of the lipid ...

    Authors: Peter P Toth, Robert J Simko, Swetha Rao Palli, Dawn Koselleck, Ralph A Quimbo and Mark J Cziraky
    Citation: Cardiovascular Diabetology 2012 11:109
    Content type: Original investigation Published on:

  38. All of the components of Metabolic syndrome (MetS) have been regarded as risk factors for coronary artery disease (CAD). Early detection of CAD in asymptomatic patients with MetS remains a challenge. Cystatin ...

    Authors: Xie Qing, Wang Furong, Liu Yunxia, Zhang Jian, Wang Xuping and Gao Ling
    Citation: Cardiovascular Diabetology 2012 11:108
    Content type: Original investigation Published on:

  39. We recently reported that short-term treatment with liraglutide (20.0 ± 6.4 days) reduced body weight and improved some scales of eating behavior in Japanese type 2 diabetes inpatients. However, it remained un...

    Authors: Yuya Fujishima, Norikazu Maeda, Kana Inoue, Susumu Kashine, Hitoshi Nishizawa, Ayumu Hirata, Junji Kozawa, Tetsuyuki Yasuda, Kohei Okita, Akihisa Imagawa, Tohru Funahashi and Iichiro Shimomura
    Citation: Cardiovascular Diabetology 2012 11:107
    Content type: Original investigation Published on:

  40. Growing evidence suggests that epicardial adipose tissue (EAT) may contribute to the development of coronary artery disease (CAD). In this study, we explored gender disparities in EAT volume (EATV) and its imp...

    Authors: Munkhbaatar Dagvasumberel, Michio Shimabukuro, Takeshi Nishiuchi, Junji Ueno, Shoichiro Takao, Daiju Fukuda, Yoichiro Hirata, Hirotsugu Kurobe, Takeshi Soeki, Takashi Iwase, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Shusuke Yagi, Noriko Tomita…
    Citation: Cardiovascular Diabetology 2012 11:106
    Content type: Original investigation Published on:

  41. Recent studies revealed that erythropoietin (EPO) has tissue-protective effects in the heart by increasing vascular endothelial growth factor (VEGF) expression and attenuating myocardial fibrosis in ischemia m...

    Authors: Jing Lu, Yu-yu Yao, Qi-ming Dai, Gen-shan Ma, Shu-feng Zhang, Lei Cao, Li-qun Ren and Nai-feng Liu
    Citation: Cardiovascular Diabetology 2012 11:105
    Content type: Original investigation Published on:

  42. Many patients who survive a myocardial infarction (MI) remain at risk of sudden cardiac death despite revascularization and optimal medical treatment. We used the modified moving average (MMA) method to assess...

    Authors: Ren Li-na, Fang Xin-hui, Ren Li-dong, Gong Jian, Wang Yong-quan and Qi Guo-xian
    Citation: Cardiovascular Diabetology 2012 11:104
    Content type: Original investigation Published on:

  43. Endothelial dysfunction is an independent risk factor for cardiovascular events. Inflammatory mediators released by the adipose tissue can lead to local insulin resistance and endothelial dysfunction. This stu...

    Authors: Anna Solini, Francesco Stea, Eleonora Santini, Rosa Maria Bruno, Emiliano Duranti, Stefano Taddei and Lorenzo Ghiadoni
    Citation: Cardiovascular Diabetology 2012 11:103
    Content type: Original investigation Published on:

  44. Since post-infarction heart failure (HF) determines a great morbidity and mortality, and given the physiopathology implications of advanced glycation end products (AGE) in the genesis of myocardial dysfunction...

    Authors: Sergio Raposeiras-Roubín, Bruno K Rodiño-Janeiro, Beatriz Paradela-Dobarro, Lilian Grigorian-Shamagian, José M García-Acuña, Pablo Aguiar-Souto, Michel Jacquet-Hervet, María V Reino-Maceiras, Ezequiel Álvarez and José R González-Juanatey
    Citation: Cardiovascular Diabetology 2012 11:102
    Content type: Original investigation Published on:

  45. Type 2 diabetes mellitus (T2DM) patients are at increased risk of developing cardiovascular events. Unfortunately traditional risk assessment scores, including the Framingham Risk Score (FRS), have only modest...

    Authors: Kui-Kai Lau, Yuen-Kwun Wong, Yap-Hang Chan, Kai-Hang Yiu, Kay-Cheong Teo, Leonard Sheung-Wai Li, Shu-Leong Ho, Koon-Ho Chan, Chung-Wah Siu and Hung-Fat Tse
    Citation: Cardiovascular Diabetology 2012 11:101
    Content type: Original investigation Published on:

  46. Metabolic syndrome is characterized by insulin resistance, which is closely related to GLUT4 content in insulin-sensitive tissues. Thus, we evaluated the GLUT4 expression, insulin resistance and inflammation, ...

    Authors: Natalia M Leguisamo, Alexandre M Lehnen, Ubiratan F Machado, Maristela M Okamoto, Melissa M Markoski, Graziela H Pinto and Beatriz D Schaan
    Citation: Cardiovascular Diabetology 2012 11:100
    Content type: Original investigation Published on:

  47. Far infra-red (IFR) therapy was shown to exert beneficial effects in cardiovascular system, but effects of IFR on endothelial progenitor cell (EPC) and EPC-related vasculogenesis remain unclear. We hypothesize...

    Authors: Po-Hsun Huang, Jaw-Wen Chen, Chih-Pei Lin, Ying-Hwa Chen, Chao-Hung Wang, Hsin-Bang Leu and Shing-Jong Lin
    Citation: Cardiovascular Diabetology 2012 11:99
    Content type: Original investigation Published on:

  48. Previous studies have demonstrated that postprandial hyperglycemia attenuates brachial artery flow-mediated dilation (FMD) in prediabetic patients, in diabetic patients, and even in normal subjects. We have pr...

    Authors: Kazunari Suzuki, Kentaro Watanabe, Shoko Futami-Suda, Hiroyuki Yano, Masayuki Motoyama, Noriaki Matsumura, Yoshimasa Igari, Tatsuya Suzuki, Hiroshi Nakano and Kenzo Oba
    Citation: Cardiovascular Diabetology 2012 11:98
    Content type: Original investigation Published on:

  49. Insulin resistance has been linked to exercise intolerance in heart failure patients. The aim of this study was to assess the potential role of coronary flow reserve (CFR), endothelial function and arterial st...

    Authors: Martin Snoer, Tea Monk-Hansen, Rasmus Huan Olsen, Lene Rørholm Pedersen, Lene Simonsen, Hanne Rasmusen, Flemming Dela and Eva Prescott
    Citation: Cardiovascular Diabetology 2012 11:97
    Content type: Original investigation Published on:

  50. The presence of diabetes mellitus poses a challenge in the treatment of patients with acute myocardial infarction (AMI). We aimed to evaluate the sex-specific outcomes of diabetic and non-diabetic patients wit...

    Authors: Mai Blöndal, Tiia Ainla, Toomas Marandi, Aleksei Baburin and Jaan Eha
    Citation: Cardiovascular Diabetology 2012 11:96
    Content type: Original investigation Published on:
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