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  1. Heart type fatty acid binding protein (H-FABP) has been closely associated with acute coronary syndrome, cardiac abnormalities, stroke, and obstructive sleep disorder in previous studies. The aim of this study...

    Authors: Basak Karbek, Mustafa Özbek, Nujen Colak Bozkurt, Zeynep Ginis, Askın Güngünes, İlknur Öztürk Ünsal, Erman Cakal and Tuncay Delibası
    Citation: Cardiovascular Diabetology 2011 10:37
    Content type: Original investigation Published on:

  2. Leptin is associated with cardiovascular disease (CVD); however, few studies have assessed its relationship with metabolic syndrome, especially in an Asian population. Therefore, the aim of the present study w...

    Authors: Wen-Cheng Li, Kuang-Yu Hsiao, I-Chuan Chen, Yu-Che Chang, Shih-Hao Wang and Kuan-Han Wu
    Citation: Cardiovascular Diabetology 2011 10:36
    Content type: Original investigation Published on:

  3. Changes in the proteoglycans glypican and syndecan-4 have been reported in several pathological conditions, but little is known about their expression in the heart during diabetes. The aim of this study was to...

    Authors: Célia MC Strunz, Monique Matsuda, Vera MC Salemi, Adriana Nogueira, Antonio P Mansur, Ismar N Cestari and Monica V Marquezini
    Citation: Cardiovascular Diabetology 2011 10:35
    Content type: Original investigation Published on:

  4. Low serum amylase levels may reflect impaired exocrine-endocrine relationship in the pancreas. However, few clinical studies have addressed this issue. Therefore, in this epidemiological study, we investigated...

    Authors: Kei Nakajima, Tohru Nemoto, Toshitaka Muneyuki, Masafumi Kakei, Hiroshi Fuchigami and Hiromi Munakata
    Citation: Cardiovascular Diabetology 2011 10:34
    Content type: Original investigation Published on:

  5. The effects of renal denervation on cardiovascular reflexes and markers of nephropathy in diabetic-hypertensive rats have not yet been explored.

    Authors: Lucinara D Dias, Karina R Casali, Natalia M Leguisamo, Felipe Azambuja, Martina S Souza, Maristela Okamoto, Ubiratan F Machado, Maria Cláudia Irigoyen and Beatriz D Schaan
    Citation: Cardiovascular Diabetology 2011 10:33
    Content type: Original investigation Published on:

    The Erratum to this article has been published in Cardiovascular Diabetology 2011 10:49

  6. Coronary artery disease (CAD) and stroke share a major linkage at the chromosome 12q24 locus. The same chromosome region entails at least a major risk gene for type 2 diabetes (T2D) within NIDDM2, the non-insu...

    Authors: Claudia Gragnoli
    Citation: Cardiovascular Diabetology 2011 10:32
    Content type: Original investigation Published on:

  7. For patients with diabetes, clinical practice guidelines recommend treating to a low-density lipoprotein cholesterol (LDL-C) goal of <2.59 mmol/L (100 mg/dL) and a blood pressure (BP) target of <130/80 mmHg. T...

    Authors: Andreas Kuznik and Jack Mardekian
    Citation: Cardiovascular Diabetology 2011 10:31
    Content type: Original investigation Published on:

  8. Increased fasting plasma glucose (FPG), which includes impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes, is a risk factor for arterial stiffness. While IFG is widely accepted as a...

    Authors: Jin Young Shin, Hye Ree Lee and Duk Chul Lee
    Citation: Cardiovascular Diabetology 2011 10:30
    Content type: Original investigation Published on:

  9. Left ventricular hypertrophy (LVH) is a strong predictor of cardiovascular disease and is common among patients with type 2 diabetes. However, no systematic screening for LVH is currently recommended for patie...

    Authors: Jithendra B Somaratne, Gillian A Whalley, Katrina K Poppe, Mariska M ter Bals, Gina Wadams, Ann Pearl, Warwick Bagg and Rob N Doughty
    Citation: Cardiovascular Diabetology 2011 10:29
    Content type: Original investigation Published on:

  10. N-terminal-pro-brain natriuretic peptide (NT-proBNP) is elevated in gestational hypertension and preeclampsia. This trial aimed to generate data for gestational diabetes mellitus patients, who are at risk to d...

    Authors: Martin Andreas, Harald Zeisler, Ammon Handisurya, Maximilian B Franz, Michael Gottsauner-Wolf, Michael Wolzt and Alexandra Kautzky-Willer
    Citation: Cardiovascular Diabetology 2011 10:28
    Content type: Original investigation Published on:

  11. Several studies have shown that common variants in the MTNR1B gene were associated with fasting glucose level and type 2 diabetes. The purpose of this study was to examine whether tagging single nucleotide polymo...

    Authors: Yan Ling, Xiaomu Li, Qian Gu, Hongyan Chen, Daru Lu and Xin Gao
    Citation: Cardiovascular Diabetology 2011 10:27
    Content type: Original investigation Published on:

  12. Although clinical diabetes mellitus is obviously a high risk factor for myocardial infarction (MI), in experimental studies disagreement exists about the sensitivity to ischemic injury of an infarcted myocardi...

    Authors: Bruno Rodrigues, Kaleizu T Rosa, Alessandra Medeiros, Beatriz D Schaan, Patricia C Brum, Kátia De Angelis and Maria Cláudia Irigoyen
    Citation: Cardiovascular Diabetology 2011 10:26
    Content type: Original investigation Published on:

  13. Aspirin has been recommended for the prevention of major adverse cardiovascular events (MACE, composite of non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death) in diabetic patients with...

    Authors: Sonia Butalia, Alexander A Leung, William A Ghali and Doreen M Rabi
    Citation: Cardiovascular Diabetology 2011 10:25
    Content type: Review Published on:

  14. Hypertension, diabetes and obesity are not isolated findings, but a series of interacting interactive physiologic derangements. Taking into account genetic background and lifestyle behavior, AI (autonomic imba...

    Authors: Leandro Boer-Martins, Valéria N Figueiredo, Caroline Demacq, Luiz C Martins, Fernanda Consolin-Colombo, Márcio J Figueiredo, Fernando PS Cannavan and Heitor Moreno Jr
    Citation: Cardiovascular Diabetology 2011 10:24
    Content type: Original investigation Published on:

  15. Increased plasma plasminogen activator inhibitor-1 (PAI-1) activity and decreased tissue plasminogen activator (tPA) activity could be considered a true component of the metabolic syndrome (MetS) associated wi...

    Authors: Zaid Al-Hamodi, Ikram S Ismail, Riyadh Saif-Ali, Khaled A Ahmed and Sekaran Muniandy
    Citation: Cardiovascular Diabetology 2011 10:23
    Content type: Original investigation Published on:

  16. It is important for patients that treatments for diabetes not increase cardiovascular (CV) risk. The objective of this analysis was to examine retrospectively the CV safety of exenatide BID, a GLP-1 receptor a...

    Authors: Robert Ratner, Jenny Han, Dawn Nicewarner, Irina Yushmanova, Byron J Hoogwerf and Larry Shen
    Citation: Cardiovascular Diabetology 2011 10:22
    Content type: Original investigation Published on:

  17. Although European guidelines advise oral glucose tolerance test (OGTT) in patients with acute myocardial infarction (AMI) before or shortly after hospital discharge, data supporting this recommendation are inc...

    Authors: Agata Bronisz, Marek Kozinski, Przemyslaw Magielski, Tomasz Fabiszak, Joanna Gierach, Iwona Swiatkiewicz, Adam Sukiennik, Aldona Kubica, Marek Bronisz, Zofia Grabczewska, Anna Sinkiewicz, Roman Junik and Jacek Kubica
    Citation: Cardiovascular Diabetology 2011 10:21
    Content type: Original investigation Published on:

  18. Apolipoprotein B100 (apoB) is a superior indicator of CV risk than total or LDL-C. Non-HDL-C represents a simple surrogate for apoB in hypertriglyceridemic and/or T2DM patients. ApoB and non-HDL-C show high corre...

    Authors: Michel P Hermans, Frank M Sacks, Sylvie A Ahn and Michel F Rousseau
    Citation: Cardiovascular Diabetology 2011 10:20
    Content type: Original investigation Published on:

  19. Glucose variability is one of components of the dysglycemia in diabetes and may play an important role in development of diabetic vascular complications. The objective of this study was to assess the relations...

    Authors: Gong Su, Shuhua Mi, Hong Tao, Zhao Li, Hongxia Yang, Hong Zheng, Yun Zhou and Changsheng Ma
    Citation: Cardiovascular Diabetology 2011 10:19
    Content type: Original investigation Published on:

  20. Type 2 diabetes (T2D) is strongly associated with cardiovascular risk and requires medications that improve glycemic control and other cardiovascular risk factors. The authors aimed to assess the relative effe...

    Authors: Ángel Rodríguez, Jesús Reviriego, Vasilios Karamanos, Francisco J del Cañizo, Nikolaos Vlachogiannis and Vangelis Drossinos
    Citation: Cardiovascular Diabetology 2011 10:18
    Content type: Original investigation Published on:

  21. The biological mechanisms in the association between the metabolic syndrome (MS) and various biomarkers, such as 25-hydroxyvitamin D (vit D) and magnesium, are not fully understood. Several of the proposed pre...

    Authors: Jo Røislien, Ben Van Calster and Jøran Hjelmesæth
    Citation: Cardiovascular Diabetology 2011 10:17
    Content type: Original investigation Published on:

  22. Elevated plasma levels of asymmetric dimethylarginine (ADMA) has been reported to be associated with insulin resistance and micro/macrovascular diabetic complications, and may predict cardiovascular events in ...

    Authors: Tse-Min Lu, Shing-Jong Lin, Ming-Wei Lin, Chiao-Po Hsu and Ming-Yi Chung
    Citation: Cardiovascular Diabetology 2011 10:16
    Content type: Original investigation Published on:

  23. To assess heart failure therapies in diabetic patients with preserved as compared to impaired systolic ventricular function.

    Authors: Frank Edelmann, Rolf Wachter, Hans-Dirk Düngen, Stefan Störk, Annette Richter, Raoul Stahrenberg, Till Neumann, Claus Lüers, Christiane E Angermann, Felix Mehrhof, Götz Gelbrich and Burkert Pieske
    Citation: Cardiovascular Diabetology 2011 10:15
    Content type: Original investigation Published on:

  24. Adiponectin has insulin-sensitizing and anti-atherosclerotic effects, partly mediated through its action on monocytes. We aimed to determine adiponectin levels and expression of its receptors (AdipoR1 and Adip...

    Authors: Anastasios Kollias, Panayoula C Tsiotra, Ignatios Ikonomidis, Eirini Maratou, Panayota Mitrou, Erifyli Kyriazi, Eleni Boutati, John Lekakis, Theofanis Economopoulos, Dimitrios T Kremastinos, George Dimitriadis and Sotirios A Raptis
    Citation: Cardiovascular Diabetology 2011 10:14
    Content type: Original investigation Published on:

  26. Diabetes mellitus has emerged as one of the main alarms to human health in the 21st century. Pronounced changes in the human environment, behavior and lifestyle have accompanied globalization, which resulted i...

    Authors: Edite Teixeira-Lemos, Sara Nunes, Frederico Teixeira and Flávio Reis
    Citation: Cardiovascular Diabetology 2011 10:12
    Content type: Review Published on:

  28. The peroxisome proliferator-activated receptor-γ (PPARγ) agonist rosiglitazone has been suggested to exert cardiovascular protection through the improvement of lipid metabolism, anti-inflammation, anti-prolife...

    Authors: Liqun Ren, Naifeng Liu, Hong Zhi, Yingjuan Li, Yanzhi Li, Rining Tang and Zulong Sheng
    Citation: Cardiovascular Diabetology 2011 10:10
    Content type: Original investigation Published on:

  29. Given the elevated risk of cardiovascular events and the higher prevalence of silent coronary artery disease (CAD) in diabetic versus non-diabetic patients, the need to screen asymptomatic diabetic patients fo...

    Authors: Cristina Hernández, Jaume Candell-Riera, Andreea Ciudin, Gemma Francisco, Santiago Aguadé-Bruix and Rafael Simó
    Citation: Cardiovascular Diabetology 2011 10:9
    Content type: Original investigation Published on:

  30. Adiponectin and resistin are adipokines which modulate insulin action, energy, glucose and lipid homeostasis. Meta-analyses showed that hypoadiponectinemia and hyperresistinemia are strongly associated with in...

    Authors: Cia-Hin Lau and Sekaran Muniandy
    Citation: Cardiovascular Diabetology 2011 10:8
    Content type: Original investigation Published on:

  31. Glycemic control and management of dyslipidemia to reduce cardiovascular risk are major therapeutic goals in individuals with type 2 diabetes mellitus (T2DM). This study was performed to evaluate the effects o...

    Authors: Barbara C Hansen, Xenia T Tigno, Agnes Bénardeau, Markus Meyer, Elena Sebokova and Jacques Mizrahi
    Citation: Cardiovascular Diabetology 2011 10:7
    Content type: Original investigation Published on:

  32. Glucagon-like peptide-1 (GLP-1) is a hormone predominately synthesized and secreted by intestinal L-cells. GLP-1 modulates multiple cellular functions and its receptor agonists are now used clinically for diab...

    Authors: Yong-Fu Xiao, Alena Nikolskaya, Deborah A Jaye and Daniel C Sigg
    Citation: Cardiovascular Diabetology 2011 10:6
    Content type: Original investigation Published on:

  33. Type 2 diabetes is a well-established risk factor for cardiovascular disease and is common among patients with acute myocardial infarction (MI). The extent to which patients with first-time MI develop diabetes...

    Authors: Mette L Norgaard, Charlotte Andersson, Peter Riis Hansen, Søren S Andersen, Allan Vaag, Tina K Schramm, Fredrik Folke, Lars Køber, Christian Torp-Pedersen and Gunnar H Gislason
    Citation: Cardiovascular Diabetology 2011 10:5
    Content type: Original investigation Published on:

  34. Diabetic cardiomyopathy, characterized by myocardial structural and functional changes, is a specific cardiomyopathy develops in patients with diabetes mellitus. The present study was to investigate the role o...

    Authors: Dongdong Sun, Min Shen, Jiayi Li, Weijie Li, Yingmei Zhang, Li Zhao, Zheng Zhang, Yuan Yuan, Haichang Wang and Feng Cao
    Citation: Cardiovascular Diabetology 2011 10:4
    Content type: Original investigation Published on:

  35. We examined the relationship between the intima-media thickness of the common carotid artery (CCA-IMT) and arterial stiffness, assessed by pulse wave velocity (PWV), the ambulatory arterial stiffness index (AA...

    Authors: Manuel Ángel Gómez-Marcos, José Ignacio Recio-Rodríguez, María Carmen Patino-Alonso, Cristina Agudo-Conde, Leticia Gómez-Sánchez, Emiliano Rodríguez-Sánchez, Carlos Martín-Cantera and Luís García-Ortiz
    Citation: Cardiovascular Diabetology 2011 10:3
    Content type: Original investigation Published on:

  36. Disorders of endocrine substances in epicardial adipose tissue are known causes of coronary artery disease (CAD). Adiponectin is associated with cardiovascular disease. However, expression of adiponectin in ep...

    Authors: Yuan Zhou, Yutao Wei, Lei Wang, Xianguo Wang, Xinling Du, Zongquan Sun, Nianguo Dong and Xinzhong Chen
    Citation: Cardiovascular Diabetology 2011 10:2
    Content type: Original investigation Published on:

  37. To estimate the incidence of complications, life expectancy and diabetes related mortality in the Mexican diabetic population over the next two decades using data from a nation-wide, population based survey an...

    Authors: Nancy Reynoso-Noverón, Roopa Mehta, Paloma Almeda-Valdes, Rosalba Rojas-Martinez, Salvador Villalpando, Mauricio Hernández-Ávila and Carlos A Aguilar-Salinas
    Citation: Cardiovascular Diabetology 2011 10:1
    Content type: Original investigation Published on:

  38. Diabetes mellitus counts as a major risk factor for developing atherosclerosis. The activation of protein kinase C (PKC) is commonly known to take a pivotal part in the pathogenesis of atherosclerosis, though ...

    Authors: Dieter Paul Hoyer, Yüksel Korkmaz, Sabine Grönke, Klaus Addicks, Nina Wettschureck, Stefan Offermanns and Hannes Reuter
    Citation: Cardiovascular Diabetology 2010 9:93
    Content type: Original investigation Published on:

  39. There is debate as to whether the association between C-reactive protein (CRP) and insulin resistance is independent of body fatness, particularly central obesity. Therefore, the association among CRP, insulin...

    Authors: Bin Lu, Yehong Yang, Zhihong Yang, Xiaocheng Feng, Xuanchun Wang, Zhaoyun Zhang and Renming Hu
    Citation: Cardiovascular Diabetology 2010 9:92
    Content type: Original investigation Published on:

  40. Plaque morphology directly correlates with risk of embolism and the recently developed dual-source computed tomography angiography (DSCTA) may help to detect plaques more precisely. The aim of our study was to...

    Authors: Ci He, Zhi-gang Yang, Zhi-gang Chu, Zhi-hui Dong, Heng Shao, Wen Deng, Jing Chen, Li-qing Peng, Si-shi Tang and Jia-he Xiao
    Citation: Cardiovascular Diabetology 2010 9:91
    Content type: Original investigation Published on:

  41. Endothelial inflammatory responses mediated by Toll-like receptors (TLRs), particularly TLR2 and TLR4, play an important role in atherogenesis. While Type 1 diabetes (T1D) promotes the development and progress...

    Authors: Jilin Li, Chunhua Jin, Joseph C Cleveland Jr, Lihua Ao, Dingli Xu, David A Fullerton and Xianzhong Meng
    Citation: Cardiovascular Diabetology 2010 9:90
    Content type: Original investigation Published on:

  42. The aim of the present study was to verify whether BNP might detect pre-clinical diastolic dysfunction (LVDD) in type-2 diabetic patients.

    Authors: Silvio Romano, Michele Di Mauro, Simona Fratini, Leonello Guarracini, Fabrizio Guarracini, Gianfranco Poccia and Maria Penco
    Citation: Cardiovascular Diabetology 2010 9:89
    Content type: Original investigation Published on:

  43. T2DM is associated with atherogenic dyslipidemia (AD), defined as decreased HDL-C plus raised triglycerides (TG). AD confers increased risk for CAD, even when LDL-C is at target. AD is rarely assessed due to l...

    Authors: Michel P Hermans, Sylvie A Ahn and Michel F Rousseau
    Citation: Cardiovascular Diabetology 2010 9:88
    Content type: Original investigation Published on:

  44. Metabolic syndrome (MetS) is associated with an increased risk of major cardiovascular events. Increased high-sensitivity C-reactive protein (hsCRP) levels are associated with MetS and its components. Changes ...

    Authors: Ryuichi Kawamoto, Yasuharu Tabara, Katsuhiko Kohara, Tetsuro Miki, Tomo Kusunoki, Shuzo Takayama, Masanori Abe, Tateaki Katoh and Nobuyuki Ohtsuka
    Citation: Cardiovascular Diabetology 2010 9:87
    Content type: Original investigation Published on:

  45. Low grade inflammation is of pathogenic importance in atherosclerosis and in the development of cardiovascular disease (CVD) and type 2 diabetes (T2D). Matrix GLA protein (MGP), an inhibitor of medial calcific...

    Authors: Stine B Thomsen, Camilla N Rathcke, Bo Zerahn and Henrik Vestergaard
    Citation: Cardiovascular Diabetology 2010 9:86
    Content type: Original investigation Published on:

  46. Insulin resistance (IR) has been associated with cardiovascular diseases (CVD). Heart rate variability (HRV), an index of cardiac autonomic modulation (CAM), is also associated with CVD mortality and CVD morbi...

    Authors: Sol M Rodríguez-Colón, Xian Li, Michele L Shaffer, Fan He, Edward O Bixler, Alexandros N Vgontzas, Jianwen Cai and Duanping Liao
    Citation: Cardiovascular Diabetology 2010 9:85
    Content type: Original investigation Published on:

  47. To investigate whether the known diabetes mellitus (KDM) or newly diagnosed diabetes mellitus (NDM) could be regarded as a coronary heart disease (CHD) risk equivalent among a relatively young Middle East popu...

    Authors: Farzad Hadaegh, Nooshin Fahimfar, Davood Khalili, Farhad Sheikholeslami and Fereidoun Azizi
    Citation: Cardiovascular Diabetology 2010 9:84
    Content type: Original investigation Published on:

  48. Notwithstanding previous studies supporting independent associations between obstructive sleep apnea (OSA) and prevalence of diabetes, the underlying pathogenesis of impaired glucose regulation in OSA remains ...

    Authors: Maria Pallayova, Kimberley E Steele, Thomas H Magnuson, Michael A Schweitzer, Nathan R Hill, Shannon Bevans-Fonti and Alan R Schwartz
    Citation: Cardiovascular Diabetology 2010 9:83
    Content type: Original investigation Published on:

  49. Azelnidipine (AZL), a long-acting dihydropyridine-based calcium antagonist, has been recently approved and used for treating ischemic heart disease and cardiac remodeling after myocardial infarction, however, ...

    Authors: Vasundhara Kain, Sandeep Kumar, Amrutesh S Puranik and Sandhya L Sitasawad
    Citation: Cardiovascular Diabetology 2010 9:82
    Content type: Original investigation Published on:

  50. Higher walking levels lead to lower mortality in type 2 diabetes, but inclement weather may reduce walking. In this patient population, we conducted a longitudinal cohort study to objectively quantify seasonal...

    Authors: Kaberi Dasgupta, Lawrence Joseph, Louise Pilote, Ian Strachan, Ron J Sigal and Cathy Chan
    Citation: Cardiovascular Diabetology 2010 9:81
    Content type: Original investigation Published on:
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