World Health Organization:Obesity and overweight; WHO Fact Sheet No311. 2013,http://www.who.int/mediacentre/factsheets/fs311/en/index.html.
Google Scholar
Shaw JE, Sicree RA, Zimmet PZ: Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010, 87: 4-14. 10.1016/j.diabres.2009.10.007.
Article
CAS
PubMed
Google Scholar
Yoon KH, Lee JH, Kim JW, Cho JH, Choi YH, Ko SH, Zimmet P, Son HY: Epidemic obesity and type 2 diabetes in Asia. Lancet. 2006, 368: 1681-1688. 10.1016/S0140-6736(06)69703-1.
Article
PubMed
Google Scholar
Chan JC, Malik V, Jia W, Kadowaki T, Yajnik CS, Yoon KH, Hu FB: Diabetes in Asia. epidemiology, risk factors, and pathophysiology. JAMA. 2009, 301: 2129-2140. 10.1001/jama.2009.726.
Article
CAS
PubMed
Google Scholar
Fujimoto WY: Overview of non-insulin-dependent diabetes mellitus (NIDDM) in different population groups. Diabet Med. 1996, 13: S7-S10.
Article
CAS
PubMed
Google Scholar
Fujimoto WY, Akanuma Y, Kanazawa Y, Mashiko S, Leonetti D, Wahl P: Plasma insulin levels in Japanese and Japanese-American men with type 2 diabetes may be related to the occurrence of cardiovascular disease. Diabetes Res Clin Pract. 1989, 6: 121-127. 10.1016/0168-8227(89)90116-2.
Article
CAS
PubMed
Google Scholar
Huxley R, James WP, Barzi F, Patel JV, Lear SA, Suriyawongpaisal P, Janus E, Caterson I, Zimmet P, Prabhakaran D, Reddy S, Woodward M: Obesity in Asia Collaboration. Ethnic comparisons of the cross-sectional relationships between measures of body size with diabetes and hypertension. Obes Rev. 2008, 9: 53-61. 10.1111/j.1467-789X.2007.00439.x.
Article
PubMed
Google Scholar
Nagaya T, Yoshida H, Takahashi H, Kawai M: Increases in body mass index, even within non-obese levels, raise the risk for Type 2 diabetes mellitus: a follow-up study in a Japanese population. Diabet Med. 2005, 22: 1107-1111. 10.1111/j.1464-5491.2005.01602.x.
Article
CAS
PubMed
Google Scholar
Oh SW, Shin SA, Yun YH, Yoo T, Huh BY: Cut-off point of BMI and obesity-related comorbidities and mortality in middle-aged Koreans. Obes Res. 2004, 12: 2031-2040. 10.1038/oby.2004.254.
Article
PubMed
Google Scholar
Neeland IJ, Ayers CR, Rohatgi AK, Turer AT, Berry JD, Das SR, Vega GL, Khera A, McGuire DK, Grundy SM, de Lemos JA: Associations of visceral and abdominal subcutaneous adipose tissue with markers of cardiac and metabolic risk in obese adults. Obesity (Silver Spring). 2012, 10.1002/oby.20135. Epub ahead of print
Google Scholar
Iwahashi H, Okauchi Y, Ryo M, Noguchi M, Morita S, Kishida K, Okita K, Ohira T, Funahashi T, Nakamura T, Imagawa A, Shimomura I: Insulin-secretion capacity in normal glucose tolerance, impaired glucose tolerance, and diabetes in obese and non-obese Japanese patients. J Diabetes Invest. 2012, 3: 271-275. 10.1111/j.2040-1124.2011.00180.x.
Article
CAS
Google Scholar
Okauchi Y, Nishizawa H, Funahashi T, Ogawa T, Noguchi M, Ryo M, Kihara S, Iwahashi H, Yamagata K, Nakamura T, Shimomura I, Matsuzawa Y: Reduction of visceral fat is associated with decrease in the number of metabolic risk factors in Japanese men. Diabetes Care. 2007, 30: 2392-2394. 10.2337/dc07-0218.
Article
PubMed
Google Scholar
Kissebah AH, Vydelingum N, Murray R, Evans DJ, Hartz AJ, Kalkhoff RK, Adams PW: Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab. 1982, 54: 254-260. 10.1210/jcem-54-2-254.
Article
CAS
PubMed
Google Scholar
Nakamura T, Tokunaga K, Shimomura I, Nakamura T, Tokunaga K, Shimomura I, Nishida M, Yoshida S, Kotani K, Islam AH, Keno Y, Kobatake T, Nagai Y, Fujioka S, Tarui S, Matsuzawa Y: Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese men. Atherosclerosis. 1994, 107: 239-246. 10.1016/0021-9150(94)90025-6.
Article
CAS
PubMed
Google Scholar
Shimomura I, Funahashi T, Takahashi M, Maeda K, Kotani K, Nakamura T, Yamashita S, Miura M, Fukuda Y, Takemura K, Tokunaga K, Matsuzawa Y: Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med. 1996, 2: 800-803. 10.1038/nm0796-800.
Article
CAS
PubMed
Google Scholar
Hotmisligli GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM: Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. J Clin Invest. 1995, 95: 2409-2415. 10.1172/JCI117936.
Article
Google Scholar
Lindsay RS, Funahashi T, Hanson RL, Matsuzawa Y, Tanaka S, Tataranni PA, Knowler WC, Krakoff J: Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet. 2002, 360: 57-58. 10.1016/S0140-6736(02)09335-2.
Article
CAS
PubMed
Google Scholar
Ryo M, Nakamura T, Kihara S, Kumada M, Shibazaki S, Takahashi M, Nagai M, Matsuzawa Y, Funahashi T: Adiponectin as a biomarker of the metabolic syndrome. Circ J. 2004, 68: 975-981. 10.1253/circj.68.975.
Article
CAS
PubMed
Google Scholar
Mallamaci F, Zoccali C, Cuzzola F, Tripepi G, Cutrupi S, Parlongo S, Tanaka S, Ouchi N, Kihara S, Funahashi T, Matsuzawa Y: Adiponectin in essential hypertension. J Nephrol. 2002, 15: 507-511.
CAS
PubMed
Google Scholar
Mohammadreza B, Farzad H, Davoud K, Fereidoun Prof AF: Prognostic significance of the complex “Visceral Adiposity Index” vs. simple anthropometric measures: Tehran lipid and glucose study. Cardiovasc Diabetol. 2012, 11-20.
Google Scholar
Hiuge-Shimizu A, Kishida K, Funahashi T, Ishizaka Y, Oka R, Okada M, Suzuki S, Takaya N, Nakagawa T, Fukui T, Fukuda H, Watanabe N, Yoshizumi T, Nakamura T, Matsuzawa Y, Yamakado M, Shimomura I: Absolute value of visceral fat area measured on computed tomography scans and obesity-related cardiovascular risk factors in large-scale Japanese general population (the VACATION-J study). Ann Med. 2012, 44: 82-92. 10.3109/07853890.2010.526138.
Article
PubMed
Google Scholar
New criteria for ‘obesity disease’ in Japan. Examination Committee of Criteria for ‘Obesity Disease’ in Japan; Japan Society for the Study of Obesity: New criteria for ‘obesity disease’ in Japan. Examination Committee of Criteria for ‘Obesity Disease’ in Japan. Circ J. 2002, 66: 987-992. 10.1253/circj.66.987.
Article
Google Scholar
Teramoto T, Sasaki J, Ueshima H, Egusa G, Kinoshita M, Shimamoto K, Daida H, Biro S, Hirobe K, Funahashi T, Yokote K, Yokode M: Metabolic syndrome. J Atheroscler Thromb. 2008, 15: 1-5. 10.5551/jat.E580.
Article
PubMed
Google Scholar
Kashiwagi A, Kasuga M, Araki E, Oka Y, Hanafusa T, Ito H, Tominaga M, Oikawa S, Noda M, Kawamura T, Sanke T, Namba M, Hashiramoto M, Sasahara T, Nishio Y, Kuwa K, Ueki K, Takei I, Umemoto M, Murakami M, Yamakado M, Yatomi Y, Ohashi H: International clinical harmonization of glycated hemoglobin in Japan : From Japan Diabetes Society to National Glycohemoglobin Standardization Program values. J Diabetes Invest. 2012, 3: 39-40. 10.1111/j.2040-1124.2012.00207.x.
Article
Google Scholar
Yki-Järvinen H, Esko N, Eero H, Marja-Riitta T: Clinical benefits and mechanisms of a sustained response to intermittent insulin therapy in type 2 diabetic patients with secondary drug failure. Am J Med. 1988, 84: 185-92. 10.1016/0002-9343(88)90412-3.
Article
PubMed
Google Scholar
Hiatt WR: Medical Treatment of Peripheral Arterial Disease and Claudication. N Engl J Med. 2001, 344: 1608-1621. 10.1056/NEJM200105243442108.
Article
CAS
PubMed
Google Scholar
Mohler ER: Peripheral arterial disease: identification and implications. Arch Intern Med. 2003, 163: 2306-2314. 10.1001/archinte.163.19.2306.
Article
PubMed
Google Scholar
Smith U, Hammersten J, Björntorp P, Kral JG: Regional differences and effect of weight reduction on human fat cell metabolism. Eur J Clin Invest. 1979, 9: 327-332. 10.1111/j.1365-2362.1979.tb00892.x.
Article
CAS
PubMed
Google Scholar
Mittelman SD, Van Citters GW, Kirkman EL, Bergman RN: Extreme insulin resistance of the central adipose depot in vivo. Diabetes. 2002, 51: 755-761. 10.2337/diabetes.51.3.755.
Article
CAS
PubMed
Google Scholar
Londos C, Brasaemle DL, Schultz CJ, Adler-Wailes DC, Levin DM, Kimmel AR, Rondinone CM: On the control of lipolysis in adipocytes. Ann N Y Acad Sci. 1999, 892: 155-168. 10.1111/j.1749-6632.1999.tb07794.x.
Article
CAS
PubMed
Google Scholar
Kuriyama H, Yamashita S, Shimomura I, Funahashi T, Ishigami M, Aragane K, Miyaoka K, Nakamura T, Takemura K, Man Z, Toide K, Nakayama N, Fukuda Y, Lin MC, Wetterau JR, Matsuzawa Y: Enhanced expression of hepatic acyl-coenzyme A synthetase and microsomal triglyceride transfer protein messenger RNAs in the obese and hypertriglyceridemic rat with visceral fat accumulation. Hepatology. 1998, 27: 557-562. 10.1002/hep.510270233.
Article
CAS
PubMed
Google Scholar
White DA, Bennett AJ, Billett MA, Salter AM: The assembly of triacylglycerol-rich lipoproteins: an essential role for the microsomal triacylglycerol transfer protein. Br J Nutr. 1998, 80: 219-229.
CAS
PubMed
Google Scholar
Adeli K, Taghibiglou C, Van Iderstine SC, Lewis GF: Mechanisms of hepatic very low-density lipoprotein overproduction in insulin resistance. Trends Cardiovasc Med. 2001, 11: 170-176. 10.1016/S1050-1738(01)00084-6.
Article
CAS
PubMed
Google Scholar
Kuriyama H, Shimomura I, Kishida K, Kondo H, Furuyama N, Nishizawa H, Maeda N, Matsuda M, Nagaretani H, Kihara S, Nakamura T, Tochino Y, Funahashi T, Matsuzawa Y: Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9. Diabetes. 2002, 51: 2915-2921. 10.2337/diabetes.51.10.2915.
Article
CAS
PubMed
Google Scholar
Maeda N, Funahashi T, Shimomura I: Metabolic impact of adipose and hepatic glycerol channels aquaporin 7 and aquaporin 9. Nat Clin Pract Endocrinol Metab. 2008, 4: 627-34.
CAS
PubMed
Google Scholar
Spiegelman BM, Flier JS: Obesity and the regulation of energy balance. Cell. 2001, 23: 531-543.
Article
Google Scholar
Matsuzawa Y, Funahashi T, Nakamura T: The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism. J Atheroscler Thromb. 2011, 18: 629-639. 10.5551/jat.7922.
Article
CAS
PubMed
Google Scholar
Maeda N, Takahashi M, Funahashi T, Kihara S, Nishizawa H, Kishida K, Nagaretani H, Matsuda M, Komuro R, Ouchi N, Kuriyama H, Hotta K, Nakamura T, Shimomura I, Matsuzawa Y: PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes. 2001, 50: 2094-2099. 10.2337/diabetes.50.9.2094.
Article
CAS
PubMed
Google Scholar
Kurata A, Nishizawa H, Kihara S, Maeda N, Sonoda M, Okada T, Ohashi K, Hibuse T, Fujita K, Yasui A, Hiuge A, Kumada M, Kuriyama H, Shimomura I, Funahashi T: Blockade of Angiotensin II type-1 receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation. Kidney Int. 2006, 70: 1717-1724. 10.1038/sj.ki.5001810.
Article
CAS
PubMed
Google Scholar
Hiuge A, Tenenbaum A, Maeda N, Benderly M, Kumada M, Fisman EZ, Tanne D, Matas Z, Hibuse T, Fujita K, Nishizawa H, Adler Y, Motro M, Kihara S, Shimomura I, Behar S, Funahashi T: Effects of peroxisome proliferator-activated receptor ligands, bezafibrate and fenofibrate, on adiponectin level. Arterioscler Thromb Vasc Biol. 2007, 27: 635-641. 10.1161/01.ATV.0000256469.06782.d5.
Article
CAS
PubMed
Google Scholar
Inoue K, Maeda N, Kashine S, Fujishima Y, Kozawa J, Hiuge-Shimizu A, Okita K, Imagawa A, Funahashi T, Shimomura I: Short-term effects of liraglutide on visceral fat adiposity, appetite, and food preference: a pilot study of obese Japanese patients with type 2 diabetes. Cardiovasc Diabetol. 2011, 10: 109-10.1186/1475-2840-10-109.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fujishima Y, Maeda N, Inoue K, Kashine S, Nishizawa H, Hirata A, Kozawa J, Yasuda T, Okita K, Imagawa A, Funahashi T, Shimomura I: Efficacy of liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, on body weight, eating behavior, and glycemic control, in Japanese obese type 2 diabetes. Cardiovasc Diabetol. 2012, 11: 107-10.1186/1475-2840-11-107.
Article
PubMed Central
CAS
PubMed
Google Scholar
Yoshida Y, Hagura R, Hara Y, Sugasawa G, Akanuma Y: Risk factors for the development of diabetic retinopathy in Japanese type 2 diabetic patients. Diabetes Res Clin Pract. 2001, 51: 195-203. 10.1016/S0168-8227(00)00212-6.
Article
CAS
PubMed
Google Scholar
Stratton IM, Kohner EM, Aldington SJ, Turner RC, Holman RR, Manley SE, Matthews DR, UKPDS 50: risk factors for incidence and progression of retinopathy in Type II diabetes over 6 years from diagnosis. Diabetologia. 2001, 44: 156-163. 10.1007/s001250051594.
Article
CAS
PubMed
Google Scholar
The Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993, 329: 977-986.
Article
Google Scholar
UK Prospective Diabetes Study (UKPDS) Group: Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998, 352: 837-853.
Article
Google Scholar
Lee IT, Chiu YF, Hwu CM, He CT, Chiang FT, Lin YC, Assimes T, Curb JD, Sheu WH: Central obesity is important but not essential component of the metabolic syndrome for predicting diabetes mellitus in a hypertensive family-based cohort. Results from the Stanford Asia-pacific program for hypertension and insulin resistance (SAPPHIRe) Taiwan follow-up study. Cardiovasc Diabetol. 2012, 11: 43-10.1186/1475-2840-11-43.
Article
PubMed Central
PubMed
Google Scholar
Nooyens AC, van Duijnhoven FJ, Verschuren WM, Boer JM, van der A DL: All-cause mortality risk of metabolically healthy abdominal obese individuals: The EPIC-MORGEN study. Obesity (Silver Spring). 2013, 10.1002/oby.20480. Epub ahead of print
Google Scholar