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  1. The risk-benefit ratio of aspirin therapy in prevention of cardiovascular disease (CVD) remains contentious, especially in type 2 diabetes. This study examined the benefit and harm of low-dose aspirin (daily d...

    Authors: Wilson Y Leung, Wing-yee So, Derek Stewart, Augustine Lui, Peter C Tong, Gary T Ko, Alice P Kong, Ronald C Ma, Francis K Chan, Xilin Yang, Sau-chu Chiang and Juliana C Chan
    Citation: Cardiovascular Diabetology 2009 8:57
    Content type: Original investigation Published on:

  2. The function of endothelial progenitor cells (EPCs), which are key cells in vascular repair, is impaired in diabetes mellitus. Nitric oxide (NO) and reactive oxygen species can regulate EPC functions. EPCs tol...

    Authors: Saher Hamed, Benjamin Brenner, Anat Aharon, Deeb Daoud and Ariel Roguin
    Citation: Cardiovascular Diabetology 2009 8:56
    Content type: Original investigation Published on:

  3. Increased resting heart rate (RHR) may be associated with increased cardiovascular morbidity. Our aim was to explore the possibility that increased RHR is associated with the prevalence of the metabolic syndro...

    Authors: Ori Rogowski, Arie Steinvil, Shlomo Berliner, Michael Cohen, Nili Saar, Orit Kliuk Ben-Bassat and Itzhak Shapira
    Citation: Cardiovascular Diabetology 2009 8:55
    Content type: Original investigation Published on:

  4. Cardiovascular disease is the main cause of premature death in patients with type 1 diabetes. Patients with diabetic kidney disease have an increased risk of heart attack or stroke. Accurate knowledge of the c...

    Authors: Ville-Petteri Mäkinen, Carol Forsblom, Lena M Thorn, Johan Wadén, Kimmo Kaski, Mika Ala-Korpela and Per-Henrik Groop
    Citation: Cardiovascular Diabetology 2009 8:54
    Content type: Original investigation Published on:

  5. Patients with type 2 diabetes are at increased risk of cardiovascular events, and there is an associated economic burden attached to this risk. We conducted a retrospective claims database analysis to evaluate...

    Authors: Robert J Straka, Larry Z Liu, Prafulla S Girase, Allyson DeLorenzo and Richard H Chapman
    Citation: Cardiovascular Diabetology 2009 8:53
    Content type: Original investigation Published on:

  6. Metabolic syndrome increases cardiovascular risk. Limited information on its prevalence in Latin America is available. The Cardiovascular Risk Factor Multiple Evaluation in Latin America (CARMELA) study includ...

    Authors: Jorge Escobedo, Herman Schargrodsky, Beatriz Champagne, Honorio Silva, Carlos P Boissonnet, Raul Vinueza, Marta Torres, Rafael Hernandez and Elinor Wilson
    Citation: Cardiovascular Diabetology 2009 8:52
    Content type: Original investigation Published on:

  7. The GOOD (Global Cardiometabolic Risk Profile in Patients with Hypertension Disease) survey showed that blood pressure control was significantly worse in hypertensive patients with metabolic syndrome and/or di...

    Authors: Walter Zidek, Lisa Naditch-Brûlé, Stefano Perlini, Csaba Farsang and Sverre E Kjeldsen
    Citation: Cardiovascular Diabetology 2009 8:51
    Content type: Original investigation Published on:

  8. Myocardial infarction results as a consequence of atherosclerotic plaque rupture, with plaque stability largely depending on the lesion forming extracellular matrix components. Lipid enriched non-calcified les...

    Authors: Michael Lehrke, Martin Greif, Uli C Broedl, Corinna Lebherz, Rüdiger P Laubender, Alexander Becker, Franz von Ziegler, Janine Tittus, Maximilian Reiser, Christoph Becker, Burkhard Göke, Gerhard Steinbeck, Alexander W Leber and Klaus G Parhofer
    Citation: Cardiovascular Diabetology 2009 8:50
    Content type: Original investigation Published on:

  9. Type 2 diabetes mellitus (T2DM) is commonly associated with both microvascular and macrovascular complications and a strong correlation exists between glycaemic control and the incidence and progression of vas...

    Authors: Federico Biscetti, Giuseppe Straface, Vincenzo Arena, Egidio Stigliano, Giovanni Pecorini, Paola Rizzo, Giulia De Angelis, Luigi Iuliano, Giovanni Ghirlanda and Andrea Flex
    Citation: Cardiovascular Diabetology 2009 8:49
    Content type: Original investigation Published on:

  10. Thrombosis is regarded to be a key factor in the development of acute coronary syndromes in patients with coronary artery disease (CAD). We hypothesize, that hemostatic and rheological risk factors may be of m...

    Authors: Thomas W Jax, Ansgar J Peters, Gunnar Plehn and Frank-Chris Schoebel
    Citation: Cardiovascular Diabetology 2009 8:48
    Content type: Original investigation Published on:

  11. Endothelial progenitor cells play an important role in vascular wall repair. Patients with type 1 diabetes have reduced levels of endothelial progenitor cells of which their functional capacity is impaired. Re...

    Authors: Olivia van Oostrom, Dominique PV de Kleijn, Joost O Fledderus, Mario Pescatori, Andrew Stubbs, Attie Tuinenburg, Sai Kiang Lim and Marianne C Verhaar
    Citation: Cardiovascular Diabetology 2009 8:47
    Content type: Original investigation Published on:

  12. Heparan sulfate proteoglycans (HSPGs) contain glycosaminoglycan (GAG) chains made primarily of heparan sulfate (HS). Hyperglycemia in diabetes leads to endothelial injury and nephropathy, retinopathy and ather...

    Authors: Juying Han, Fuming Zhang, Jin Xie, Robert J Linhardt and Linda M Hiebert
    Citation: Cardiovascular Diabetology 2009 8:46
    Content type: Original investigation Published on:

  13. Nε-Carboxymethyllysine (CML) is the major non-cross linking advanced glycation end product (AGE). CML is elevated in diabetic patients and apparent in atherosclerotic lesions. AGEs are associated with hypertensi....

    Authors: Marcus Baumann, Tom Richart, Daniel Sollinger, Jaroslav Pelisek, Marcel Roos, Tatiana Kouznetsova, Hans-Henning Eckstein, Uwe Heemann and Jan A Staessen
    Citation: Cardiovascular Diabetology 2009 8:45
    Content type: Original investigation Published on:

  14. All previous studies that investigated the association between abdominal fat distribution and insulin resistance evaluated subcutaneous and visceral fat area and/or volume, but these values were not related to...

    Authors: Yoshinori Miyazaki and Ralph A DeFronzo
    Citation: Cardiovascular Diabetology 2009 8:44
    Content type: Original investigation Published on:

  15. Maternal diabetes affects the developing fetal cardiovascular system. Newborn offspring of diabetic mothers can have a transient cardiomyopathy. We hypothesized that cardiomyopathic remodeling is associated wi...

    Authors: Benjamin E Reinking, Elesa W Wedemeyer, Robert M Weiss, Jeffrey L Segar and Thomas D Scholz
    Citation: Cardiovascular Diabetology 2009 8:43
    Content type: Original investigation Published on:

  16. White adipose tissue (WAT) is a disperse organ acting as energy storage depot and endocrine/paracrine controlling factor in the management of energy availability and inflammation. WAT sites response under ener...

    Authors: María del Mar Romero, José Antonio Fernández-López, Montserrat Esteve and Marià Alemany
    Citation: Cardiovascular Diabetology 2009 8:42
    Content type: Original investigation Published on:

  17. The prevalence of diabetes is increasing rapidly, and individuals with diabetes are at high risk for cardiovascular disorders. Subsequently the percentage of patients with diabetes subjected to revascularisati...

    Authors: Chris PH Lexis, Braim M Rahel, Joan G Meeder, Felix Zijlstra and Iwan CC van der Horst
    Citation: Cardiovascular Diabetology 2009 8:41
    Content type: Review Published on:

  18. A meta-analysis suggested the use of rosiglitazone was associated with an increased risk for cardiovascular (CV) events. Rosiglitazone remained available for use as more definitive safety trials were ongoing. ...

    Authors: Doreen M Rabi, Adriane M Lewin, Garielle E Brown, Alun L Edwards, Jeffrey A Johnson and William A Ghali
    Citation: Cardiovascular Diabetology 2009 8:40
    Content type: Review Published on:

  19. In vitro data suggest that changes in myocardial substrate metabolism may contribute to impaired myocardial function in diabetic cardiomyopathy (DCM). The purpose of the present study was to study in a rat model ...

    Authors: Charissa E van den Brom, Marc C Huisman, Ronald Vlasblom, Nicky M Boontje, Suzanne Duijst, Mark Lubberink, Carla FM Molthoff, Adriaan A Lammertsma, Jolanda van der Velden, Christa Boer, D Margriet Ouwens and Michaela Diamant
    Citation: Cardiovascular Diabetology 2009 8:39
    Content type: Original investigation Published on:

  21. Bariatric surgery is able to improve glucose and lipid metabolism, and cardiovascular function in morbid obesity. Aim of this study was to compare the long-term effects of malabsorptive (biliary pancreatic div...

    Authors: Antonio E Pontiroli, Marco Laneri, Annamaria Veronelli, Francesca Frigè, Giancarlo Micheletto, Franco Folli, Gianfranco Adami and Nicola Scopinaro
    Citation: Cardiovascular Diabetology 2009 8:37
    Content type: Original investigation Published on:

  22. We investigated whether macronutrient composition of energy-restricted diets influences the efficacy of a telemedically guided weight loss program.

    Authors: Sabine Frisch, Armin Zittermann, Heiner K Berthold, Christian Götting, Joachim Kuhn, Knut Kleesiek, Peter Stehle and Heinrich Körtke
    Citation: Cardiovascular Diabetology 2009 8:36
    Content type: Original investigation Published on:

  23. Our aim was to compare the effects of a Paleolithic ('Old Stone Age') diet and a diabetes diet as generally recommended on risk factors for cardiovascular disease in patients with type 2 diabetes not treated w...

    Authors: Tommy Jönsson, Yvonne Granfeldt, Bo Ahrén, Ulla-Carin Branell, Gunvor Pålsson, Anita Hansson, Margareta Söderström and Staffan Lindeberg
    Citation: Cardiovascular Diabetology 2009 8:35
    Content type: Original investigation Published on:

  24. Few studies have assessed secular changes in the levels of cardiovascular risk factors (CV-RF) in populations of low or middle income countries. The systematic collection of a broad set of both traditional and...

    Authors: Pascal Bovet, Sarah Romain, Conrad Shamlaye, Shanti Mendis, Roger Darioli, Walter Riesen, Luc Tappy and Fred Paccaud
    Citation: Cardiovascular Diabetology 2009 8:34
    Content type: Original investigation Published on:

  25. Both obesity and type 2 diabetes are among the risk factors for breast cancer development. Combined effect of these metabolic abnormalities on breast cancer risk however, has not been examined in premenopausal...

    Authors: Majed S Alokail, Nasser M Al-Daghri, Omar S Al-Attas and Tajamul Hussain
    Citation: Cardiovascular Diabetology 2009 8:33
    Content type: Original investigation Published on:

  26. In streptozotocin-injected rats (STZ-rats), we previously demonstrated a role for angiotensin II (AT-II) in cardiac remodelling and insulin resistance partially counteracted by in vivo treatment with losartan, an...

    Authors: Paola Failli, Chiara Alfarano, Sergio Franchi-Micheli, Edoardo Mannucci, Elisabetta Cerbai, Alessandro Mugelli and Laura Raimondi
    Citation: Cardiovascular Diabetology 2009 8:32
    Content type: Original investigation Published on:

  27. A variant in the promoter of the human uncoupling protein 2 (UCP2) gene, the G-866A polymorphism, has been associated with future risk of coronary heart disease events, in those devoid of traditional risk fact...

    Authors: Barry R Palmer, Courtney L Devereaux, Sukhbir S Dhamrait, Tessa J Mocatta, Anna P Pilbrow, Chris M Frampton, Lorraine Skelton, Tim G Yandle, Christine C Winterbourn, A Mark Richards, Hugh E Montgomery and Vicky A Cameron
    Citation: Cardiovascular Diabetology 2009 8:31
    Content type: Original investigation Published on:

  28. The study examined changes in and relationship between body mass index (BMI), leptin and adiponectin levels over a 3-year period in a pediatric population-based cohort.

    Authors: Rimei Nishimura, Hironari Sano, Toru Matsudaira, Aya Morimoto, Yumi Miyashita, Takako Shirasawa, Akatsuki Kokaze and Naoko Tajima
    Citation: Cardiovascular Diabetology 2009 8:30
    Content type: Original investigation Published on:

  29. We have recently demonstrated in man that a functional allelic polymorphism in the Haptoglobin (Hp) gene plays a major role in determining survival and congestive heart failure after myocardial infarction (MI)...

    Authors: Roy Asaf, Shany Blum, Ariel Roguin, Shiri Kalet-Litman, Jad Kheir, Avi Frisch, Rachel Miller-Lotan and Andrew P Levy
    Citation: Cardiovascular Diabetology 2009 8:29
    Content type: Original investigation Published on:

  30. Type 2 diabetes mellitus (T2DM) is a genetically heterogeneous disease, hepatocyte nuclear factor-1 homeobox A (HNF1A) single-nucleotide polymorphisms (SNPs) playing a minor role in its pathogenesis. HNF1A is a f...

    Authors: Fernando MA Giuffrida, Gilberto K Furuzawa, Teresa S Kasamatsu, Marcos M Oliveira, Andre F Reis and Sergio A Dib
    Citation: Cardiovascular Diabetology 2009 8:28
    Content type: Original investigation Published on:

  31. Asymmetric dimethylarginine (ADMA) is a competitive inhibitor of endothelial nitric oxide synthase (eNOS) that is associated with endothelial dysfunction, and is a risk marker for cardiovascular disease, a sig...

    Authors: Latika Sibal, Sharad C Agarwal, Edzard Schwedhelm, Nicole Lüneburg, Rainer H Böger and Philip D Home
    Citation: Cardiovascular Diabetology 2009 8:27
    Content type: Original investigation Published on:

  33. The benefit of statins for prevention of cardiovascular events in type 2 diabetes is established, but a gap exists between guideline recommendations and clinical practice. The aim of the study was to identify ...

    Authors: Heiner K Berthold, Ioanna Gouni-Berthold, Michael Böhm, Wilhelm Krone and Kurt P Bestehorn
    Citation: Cardiovascular Diabetology 2009 8:25
    Content type: Original investigation Published on:

  36. Non-human primates are valuable models for the study of insulin resistance and human obesity. In baboons, insulin sensitivity levels can be evaluated directly with the euglycemic clamp and is highly predicted ...

    Authors: Alberto O Chavez, Amalia Gastaldelli, Rodolfo Guardado-Mendoza, Juan C Lopez-Alvarenga, M Michelle Leland, M Elizabeth Tejero, GianPio Sorice, Francesca Casiraghi, Alberto Davalli, Raúl A Bastarrachea, Anthony G Comuzzie, Ralph A DeFronzo and Franco Folli
    Citation: Cardiovascular Diabetology 2009 8:22
    Content type: Original investigation Published on:

  37. Over the last 30 years the citizens of the United Arab Emirates have experienced major changes in life-style secondary to increased affluence. Currently, 1 in 5 adults have diabetes mellitus, but the associati...

    Authors: Latifa M Baynouna, Anthony D Revel, Nico JD Nagelkerke, Tariq M Jaber, Aziza O Omar, Nader M Ahmed, Mohammad K Nazirudeen, Mamdouh F Al Sayed, Fuad A Nour and Sameh Abdouni
    Citation: Cardiovascular Diabetology 2009 8:21
    Content type: Original investigation Published on:

  38. Chronic low-grade inflammation is a significant factor in the development of obesity associated diabetes. This is supported by recent studies suggesting endotoxin, derived from gut flora, may be key to the dev...

    Authors: Omar S Al-Attas, Nasser M Al-Daghri, Khalid Al-Rubeaan, Nancy F da Silva, Shaun L Sabico, Sudhesh Kumar, Philip G McTernan and Alison L Harte
    Citation: Cardiovascular Diabetology 2009 8:20
    Content type: Original investigation Published on:

  39. Lower extremity complications (neuropathy, ulceration, infection, and peripheral arterial disease) are common in diabetes mellitus. There is an inverse relation between plasma testosterone and insulin sensitiv...

    Authors: Svetlana Kalinchenko, Alexandr Zemlyanoy and Louis J Gooren
    Citation: Cardiovascular Diabetology 2009 8:19
    Content type: Case Report Published on:

  42. Diabetic cardiomyopathy (DCM) contributes to cardiac failure in diabetic patients. It is characterized by excessive lipids accumulation, with increased triacylglycerol (TAG) stores, and fibrosis in left ventri...

    Authors: Fabien Forcheron, Alexandra Basset, Pauline Abdallah, Peggy Del Carmine, Nicolas Gadot and Michel Beylot
    Citation: Cardiovascular Diabetology 2009 8:16
    Content type: Original investigation Published on:

  43. Both insulin and thiazolidinediones (TZDs) are effective in the treatment of hyperglycaemia and amelioration of insulin resistance in type 2 diabetes but have side effects including weight gain and fluid reten...

    Authors: Mozhgan Dorkhan, Magnus Dencker, Martin Stagmo and Leif Groop
    Citation: Cardiovascular Diabetology 2009 8:15
    Content type: Original investigation Published on:

  44. Angiotensin converting enzyme (ACE) is a possible candidate gene that may influence both body fatness and blood pressure. Although several genetic studies have been conducted in adults, relatively few studies ...

    Authors: Joey C Eisenmann, Mark A Sarzynski, Kim Glenn, Max Rothschild and Kate A Heelan
    Citation: Cardiovascular Diabetology 2009 8:14
    Content type: Original investigation Published on:

  45. Obesity is a major risk factor for development and progression of hypertension and diabetes, which often coexist in obese patients. Losing weight by means of energy restriction and physical activity has been e...

    Authors: Guixiang Zhao, Earl S Ford, Chaoyang Li and Ali H Mokdad
    Citation: Cardiovascular Diabetology 2009 8:13
    Content type: Original investigation Published on:

  46. Poor control of type 2 diabetes results in substantial long-term consequences. Studies of new diabetes treatments are rarely designed to assess mortality, complication rates and costs. We sought to estimate th...

    Authors: Sean D Sullivan, Rafael Alfonso-Cristancho, Chris Conner, Mette Hammer and Lawrence Blonde
    Citation: Cardiovascular Diabetology 2009 8:12
    Content type: Original investigation Published on:

  47. The renin-angiotensin aldosterone system (RAAS) plays an important role in regulating the blood pressure and the genetic polymorphisms of RAAS genes has been extensively studied in relation to the cardiovascul...

    Authors: Vasudevan Ramachandran, Patimah Ismail, Johnson Stanslas and Norashikin Shamsudin
    Citation: Cardiovascular Diabetology 2009 8:11
    Content type: Original investigation Published on:

  48. Inflammation contributes to cardiovascular complications in type 2 diabetes, which are often characterized by microvascular alterations. We investigated whether myeloid-related protein 8/14 complex (MRP8/14) s...

    Authors: Klaus Burkhardt, Sonja Schwarz, Chengrui Pan, Felix Stelter, Konstantin Kotliar, Maxilian Von Eynatten, Daniel Sollinger, Ines Lanzl, Uwe Heemann and Marcus Baumann
    Citation: Cardiovascular Diabetology 2009 8:10
    Content type: Original investigation Published on:

  49. Insulin glargine (glargine) and premixed insulins (premix) are alternative insulin treatments. This analysis evaluated glycaemic control in 528 patients with type 1 (n = 183) or type 2 (n = 345) diabetes, afte...

    Authors: Peter Sharplin, Jason Gordon, John R Peters, Anthony P Tetlow, Andrea J Longman and Philip McEwan
    Citation: Cardiovascular Diabetology 2009 8:9
    Content type: Original investigation Published on:

  50. High glucose could induce structure and function change in cardiomyocytes, PKC plays a core effect in the onset and progression of diabetic cardiomyopathy, but its underlying downstream signal transduction pat...

    Authors: Wang Min, Zhang Wen Bin, Zhou Bin Quan, Zhu Jun Hui and Fu Guo Sheng
    Citation: Cardiovascular Diabetology 2009 8:8
    Content type: Original investigation Published on:
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ISSN: 1475-2840