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  1. Accelerated atherosclerosis is one of the major vascular complications of diabetes. Factors including hyperglycemia and hyperinsulinemia may contribute to accelerated vascular disease. Among the several mechan...

    Authors: Wenlan Duan, Latha Paka and Sivaram Pillarisetti
    Citation: Cardiovascular Diabetology 2005 4:16
    Content type: Original investigation Published on:

  2. The aim of the present study was to evaluate, by heart rate variability (HRV) with 24-hours ECG Holter (HRV), the circadian autonomic activity in offspring of type 2 diabetic subjects and the relation with ins...

    Authors: A Fiorentini, A Perciaccante, A Paris, P Serra and L Tubani
    Citation: Cardiovascular Diabetology 2005 4:15
    Content type: Original investigation Published on:

  3. There are three peroxisome proliferator-activated receptors (PPARs) subtypes which are commonly designated PPAR alpha, PPAR gamma and PPAR beta/delta. PPAR alpha activation increases high density lipoprotein (...

    Authors: Alexander Tenenbaum, Michael Motro and Enrique Z Fisman
    Citation: Cardiovascular Diabetology 2005 4:14
    Content type: Review Published on:

  4. The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study is examining the effects of long-term fibrate therapy on coronary heart disease (CHD) event rates in patients with diabetes mellitus. T...

    Authors:
    Citation: Cardiovascular Diabetology 2005 4:13
    Content type: Original investigation Published on:

  5. Uncontrolled hyperglycemia is the main risk factor in the development of diabetic vascular complications. The endothelial cells are the first cells targeted by hyperglycemia. The mechanism of endothelial injur...

    Authors: Juying Han, Anil K Mandal and Linda M Hiebert
    Citation: Cardiovascular Diabetology 2005 4:12
    Content type: Original investigation Published on:

  6. The objective of this study was to determine the rate of blood pressure control according to 4 sets of Canadian guidelines published over a decade in patients with diabetes mellitus attending Diabetes Centres ...

    Authors: Cory Russell, Peggy Dunbar, Sonia Salisbury, Ingrid Sketris and George Kephart
    Citation: Cardiovascular Diabetology 2005 4:11
    Content type: Methodology Published on:

  7. Resistin is an adipocyte-derived factor implicated in obesity-associated type 2 diabetes (T2DM). This study examines the association between human serum resistin, T2DM and coronary heart disease.

    Authors: N Al-Daghri, R Chetty, PG McTernan, K Al-Rubean, O Al-Attas, AF Jones and S Kumar
    Citation: Cardiovascular Diabetology 2005 4:10
    Content type: Original investigation Published on:

  8. The vascular endothelial basement membrane and extra cellular matrix is a compilation of different macromolecules organized by physical entanglements, opposing ionic charges, chemical covalent bonding, and cro...

    Authors: Melvin R Hayden, James R Sowers and Suresh C Tyagi
    Citation: Cardiovascular Diabetology 2005 4:9
    Content type: Review Published on:

  9. Drugs in the same class are generally thought to be therapeutically equivalent because of similar mechanisms of action (the so-called "class effect"). However, statins differ in multiple characteristics, inclu...

    Authors: Enrique Z Fisman, Yehuda Adler and Alexander Tenenbaum
    Citation: Cardiovascular Diabetology 2005 4:8
    Content type: Editorial Published on:

  10. The Use of Rosuvastatin versus Atorvastatin iN type 2 diabetes mellitUS (URANUS) study compared rosuvastatin with atorvastatin for the reduction of low-density lipoprotein cholesterol (LDL-C) in patients with ...

    Authors: Christian Berne and Annica Siewert-Delle
    Citation: Cardiovascular Diabetology 2005 4:7
    Content type: Original investigation Published on:

  11. Metabolic syndrome is a cluster of common cardiovascular risk factors that includes hypertension and insulin resistance. Hypertension and diabetes mellitus are frequent comorbidities and, like metabolic syndro...

    Authors: Cristiana Vitale, Giuseppe Mercuro, Carlotta Castiglioni, Alessandra Cornoldi, Arianna Tulli, Massimo Fini, Maurizio Volterrani and Giuseppe MC Rosano
    Citation: Cardiovascular Diabetology 2005 4:6
    Content type: Original investigation Published on:

  12. Cardiovascular complications, characterized by endothelial dysfunction and accelerated atherosclerosis, are the leading cause of morbidity and mortality associated with diabetes. There is growing evidence that...

    Authors: Jeanette Schultz Johansen, Alex K Harris, David J Rychly and Adviye Ergul
    Citation: Cardiovascular Diabetology 2005 4:5
    Content type: Review Published on:

  13. Vascular calcification is associated with metabolic syndrome, diabetes, hypertension, atherosclerosis, chronic kidney disease, and end stage renal disease. Each of the above contributes to an accelerated and p...

    Authors: Melvin R Hayden, Suresh C Tyagi, Lisa Kolb, James R Sowers and Ramesh Khanna
    Citation: Cardiovascular Diabetology 2005 4:4
    Content type: Review Published on:

  14. In the present study we tested the hypothesis that progression of streptozotocin (STZ)-induced diabetes (14-days to 28-days) would produce renal and vascular dysfunction that correlate with altered p38- mitoge...

    Authors: Hongmei Chen, Sachin Brahmbhatt, Akanksha Gupta and Avadhesh C Sharma
    Citation: Cardiovascular Diabetology 2005 4:3
    Content type: Original investigation Published on:

  15. In type 2 diabetes, free fatty acids (FFA) accumulate in microvascular cells, but the phenotypic consequences of FFA accumulation in the microvasculature are incompletely understood. Here we investigated wheth...

    Authors: Rangnath Mishra and Michael S Simonson
    Citation: Cardiovascular Diabetology 2005 4:2
    Content type: Original investigation Published on:

  16. The importance of low high-density lipoprotein cholesterol (HDL-C), elevated non HDL-C (as part of the metabolic syndrome, prediabetes, and type 2 diabetes mellitus), and an isolated low HDL-C is rapidly emerg...

    Authors: Melvin R Hayden and Suresh C Tyagi
    Citation: Cardiovascular Diabetology 2005 4:1
    Content type: Case Report Published on:

  18. Fibrates correct the typical lipid abnormalities of type 2 diabetes mellitus, yet no study, to date, has specifically set out to evaluate the role of fibrate therapy in preventing cardiovascular events in this...

    Authors:
    Citation: Cardiovascular Diabetology 2004 3:9
    Content type: Original investigation Published on:

  19. Hypertriglyceridemia in combination with low HDL cholesterol levels is a risk factor for cardiovascular disease. Our objective was to evaluate the efficacy of ciprofibrate for the treatment of this form of dys...

    Authors: Carlos A Aguilar-Salinas, Andréia Assis-Luores-Vale, Benjamín Stockins, Hector Mario Rengifo, José Dondici Filho, Abrahão Afiune Neto, Lísia Marcílio Rabelo, Kerginaldo Paulo Torres, José Egídio Paulo de Oliveira, Carlos Alberto Machado, Eliana Reyes, Victor Saavedra, Fernando Florenzano, Ma Victoria Hernández, Sergio Hernandez Jiménez, Erika Ramírez…
    Citation: Cardiovascular Diabetology 2004 3:8
    Content type: Original investigation Published on:

  20. Acute hyperglycaemia is an independent cardiovascular risk factor in Type 2 diabetes which may be mediated through increased oxidative damage to plasma low density lipoprotein, and in vitro, high glucose conce...

    Authors: Mike Sampson, Isabel Davies, Jelena Gavrilovic, Brendan Sussams, Jackie Brown, Sian Astley and David A Hughes
    Citation: Cardiovascular Diabetology 2004 3:7
    Content type: Original investigation Published on:

  21. Arterial proteoglycans are implicated in the pathogenesis of atherosclerosis by their ability to trap plasma lipoproteins in the arterial wall and by their influence on cellular migration, adhesion and prolife...

    Authors: Iris J Edwards, Janice D Wagner, Catherine A Vogl-Willis, Kenneth N Litwak and William T Cefalu
    Citation: Cardiovascular Diabetology 2004 3:6
    Content type: Original investigation Published on:

  22. Severe obesity is associated with important morbidity and increased mortality. The successes of lifestyle modifications and drug therapy have been partial and mostly unsustained in reducing obesity and its com...

    Authors: Philippe Woods, Carmen Paquette, Julie Martin, Jean-Gaston Dumesnil, Picard Marceau, Simon Marceau, Simon Biron, Frédéric Hould, Odette Lescelleur, Stéphane Lebel and Paul Poirier
    Citation: Cardiovascular Diabetology 2004 3:5
    Content type: Case Report Published on:

  24. Type 2 diabetes mellitus (DM-2) is one of the most prevalent chronic diseases of the aged and contributes to a significant amount of cardiovascular disease morbidity and mortality. Exercise training may be ben...

    Authors: Jonathan McGavock, Sandra Mandic, Richard Lewanczuk, Matthew Koller, Isabelle Vonder Muhll, Arthur Quinney, Dylan Taylor, Robert Welsh and Mark Haykowsky
    Citation: Cardiovascular Diabetology 2004 3:3
    Content type: Original investigation Published on:

  25. Microalbuminuria and subsequent progression to proteinuria and nephropathy is associated with increased oxidative stress, increased inflammatory cytokines and increased cardiovascular (CVD) risk. The common fu...

    Authors: Jeffrey W Stephens, Steven J Hurel, Jayshree Acharya and Steve E Humphries
    Citation: Cardiovascular Diabetology 2004 3:2
    Content type: Original investigation Published on:

  26. Vascularization is an exciting and complex mechanism involving angiogenesis and arteriogenesis. The metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM) are associated with multiple metabolic toxicities...

    Authors: Melvin R Hayden and Suresh C Tyagi
    Citation: Cardiovascular Diabetology 2004 3:1
    Content type: Review Published on:

  27. Impaired fibrinolysis is found in impaired glucose tolerance and type 2 diabetes, associated with components of the metabolic syndrome. There are no data concerning fibrinolysis in subjects with normal glucose...

    Authors: Mats CE Eliasson, Jan-Håkan Jansson, Bernt Lindahl and Birgitta Stegmayr
    Citation: Cardiovascular Diabetology 2003 2:19
    Content type: Original investigation Published on:

  28. Angiogenic therapy with vascular endothelial growth factor (VEGF) has been proposed as a treatment paradigm for patients suffering from an insufficiency of collateral vessels. Diabetes is associated with incre...

    Authors: Ariel Roguin, Samy Nitecki, Irit Rubinstein, Eviatar Nevo, Aaron Avivi, Nina S Levy, Zaid A Abassi, Edmond Sabo, Orit Lache, Meira Frank, Aaron Hoffman and Andrew P Levy
    Citation: Cardiovascular Diabetology 2003 2:18
    Content type: Original investigation Published on:

  29. Diabetic dyslipoproteinemia is characterized by hypertriglyceridemia, low HDL-cholesterol and often elevated LDL-cholesterol and is a strong risk factor for atherosclerosis. Adhesion molecule levels are elevat...

    Authors: Klaus Empen, Robert JA Frost, H Christian Geiss, Carsten Otto and Klaus G Parhofer
    Citation: Cardiovascular Diabetology 2003 2:17
    Content type: Original investigation Published on:

  30. Patients with diabetic cardiomyopathy have an impaired myocardial glucose handling and distal distribution of coronary atherosclerosis. Trimetazidine, an anti-ischemic metabolic agent, improves myocardial gluc...

    Authors: Giuseppe MC Rosano, Cristiana Vitale, Barbara Sposato, Giuseppe Mercuro and Massimo Fini
    Citation: Cardiovascular Diabetology 2003 2:16
    Content type: Original investigation Published on:

  31. An insertion/deletion polymorphism in the α2B-adrenoceptor (AR) has been associated with the risk for acute myocardial infarction (AMI) and sudden cardiac death. In this study we tested whether this polymorphism ...

    Authors: Amir Snapir, Mika Scheinin, Leif C Groop and Marju Orho-Melander
    Citation: Cardiovascular Diabetology 2003 2:15
    Content type: Original investigation Published on:

  32. Left ventricular hypertrophy (LVH) is a powerful independent risk factor for cardiovascular morbidity and mortality among hypertensive patients. Data regarding relationships between diabetes and LVH are contro...

    Authors: Alexander Tenenbaum, Enrique Z Fisman, Ehud Schwammenthal, Yehuda Adler, Michal Benderly, Michael Motro and Joseph Shemesh
    Citation: Cardiovascular Diabetology 2003 2:14
    Content type: Original investigation Published on:

  33. Even mild hyperglycemia is associated with future acute and chronic complications. Nevertheless, many cases of diabetes in the community go unrecognized. The aim of the study was to determine if national elect...

    Authors: Shlomo Vinker, Yaacov Fogelman, Asher Elhayany, Sasson Nakar and Ernesto Kahan
    Citation: Cardiovascular Diabetology 2003 2:13
    Content type: Original investigation Published on:

  34. More than seventeen million Americans are afflicted with diabetes and these people have four times the rate of coronary heart disease (CHD) as non-diabetics. Furthermore, diabetic women have a 3.8 fold greater...

    Authors: Hillary A Tuttle, Grace Davis-Gorman, Steven Goldman, Jack G Copeland and Paul F McDonagh
    Citation: Cardiovascular Diabetology 2003 2:12
    Content type: Original investigation Published on:

  35. The impressive correlation between cardiovascular disease and glucose metabolism alterations has raised the likelihood that atherosclerosis and type 2 diabetes may share common antecedents. Inflammation is eme...

    Authors: Enrique Z Fisman, Michael Motro and Alexander Tenenbaum
    Citation: Cardiovascular Diabetology 2003 2:11
    Content type: Hypothesis Published on:

  36. Recently a new automatic device that measures brachial-ankle pulse wave velocity using an oscillometric method has been developed. However, the practical significance of brachial-ankle pulse wave velocity meas...

    Authors: Osamu Ogawa, Tomio Onuma, Sayaka Kubo, Naomi Mitsuhashi, Chie Muramatsu and Ryuzo Kawamori
    Citation: Cardiovascular Diabetology 2003 2:10
    Content type: Original investigation Published on:

  39. A C825T polymorphism was recently identified in the gene encoding the β3 subunit of heterotrimeric G-proteins (GNB3). The T-allele is significantly associated with essential hypertension and obesity. In order to ...

    Authors: Jens Nürnberger, Sandra Dammer, Thomas Philipp, Rene R Wenzel and Rafael F Schäfers
    Citation: Cardiovascular Diabetology 2003 2:7
    Content type: Original investigation Published on:

  40. Using the streptozotocin-induced diabetic rat model, we have recently showed that the expression and function of β1-adrenoreceptor were decreased in the diabetic rat heart. However, the effect of diabetes on expr...

    Authors: U Deniz Dinçer, Şahika Güner, Aydin Tay, Ebru Arioğlu, Atilay Taşdelen, Sait Aşlamaci and Keshore R Bidasee
    Citation: Cardiovascular Diabetology 2003 2:6
    Content type: Original investigation Published on:

  41. Interleukin 8 (IL-8) is a cytokine with atherogenic properties. In vitro studies revealed that it is produced and secreted by human adipocytes. We recently reported that plasma IL-8 is increased in obese subje...

    Authors: Marek Straczkowski, Irina Kowalska, Agnieszka Nikolajuk, Stella Dzienis-Straczkowska, Malgorzata Szelachowska and Ida Kinalska
    Citation: Cardiovascular Diabetology 2003 2:5
    Content type: Original investigation Published on:

  42. The metabolic syndrome is a highly prevalent clinical entity. The recent Adult Treatment Panel (ATP III) guidelines have called specific attention to the importance of targeting the cardiovascular risk factors...

    Authors: Alexander Tenenbaum, Enrique Z Fisman and Michael Motro
    Citation: Cardiovascular Diabetology 2003 2:4
    Content type: Review Published on:

  43. Coronary plaque rupture may result from localised over expression of matrix metalloproteinases (MMPs) within the plaque by infiltrating monocyte – macrophages. As MMP expression can be promoted by the modified...

    Authors: Mark D Baugh, Jelena Gavrilovic, Isabel R Davies, David A Hughes and Mike J Sampson
    Citation: Cardiovascular Diabetology 2003 2:3
    Content type: Original investigation Published on:

  44. Cardiovascular disease accounts for at least 85 percent of deaths for those patients with type 2 diabetes mellitus (T2DM). Additionally, 75 percent of these deaths are due to ischemic heart disease.

    Authors: Melvin R Hayden and Suresh C Tyagi
    Citation: Cardiovascular Diabetology 2003 2:2
    Content type: Hypothesis Published on:

  45. Our aim is to summarize and discuss the recent literature linking diabetes mellitus with heart failure, and to address the issue of the optimal treatment for diabetic patients with heart failure.

    Authors: Christophe Bauters, Nicolas Lamblin, Eugène P Mc Fadden, Eric Van Belle, Alain Millaire and Pascal de Groote
    Citation: Cardiovascular Diabetology 2003 2:1
    Content type: Review Published on:

  46. There is little data on the relationship between novel cardiovascular risk factors and silent coronary artery disease (CAD) in diabetic patients. We investigated whether Lipoprotein(a), homocysteine and apolip...

    Authors: Carmine Gazzaruso, Adriana Garzaniti, Stefano Giordanetti, Colomba Falcone and Pietro Fratino
    Citation: Cardiovascular Diabetology 2002 1:5
    Content type: Original investigation Published on:

  47. The increase in the prevalence of insulin resistance-related metabolic syndrome, a disorder that greatly increases the risk of diabetes, heart attack and stroke, is alarming. One of the most frequent and early...

    Authors: Radka Lichnovská, Simona Gwozdziewiczová and Jirí Hrebícek
    Citation: Cardiovascular Diabetology 2002 1:4
    Content type: Original investigation Published on:

  48. Metabolic syndrome, insulin resistance, prediabetes, and overt type 2 diabetes mellitus are associated with an accelerated atherosclerosis (atheroscleropathy). This quartet is also associated with multiple met...

    Authors: Melvin R Hayden and Suresh C Tyagi
    Citation: Cardiovascular Diabetology 2002 1:3
    Content type: Review Published on:

  49. The RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan) study is a multinational, double-blind, randomized, placebo controlled trial which was recently published. It was aimed ...

    Authors: Enrique Z Fisman, Alexander Tenenbaum and Michael Motro
    Citation: Cardiovascular Diabetology 2002 1:2
    Content type: Commentary Published on:
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