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  1. Atrial fibrillation (AF), an inflammatory process involving arrhythmia, is associated with severe morbidity and mortality and commonly seen in patients with diabetes mellitus (DM). The effect of metformin, the...

    Authors: Shang-Hung Chang, Lung-Sheng Wu, Meng-Jiun Chiou, Jia-Rou Liu, Kuang-Hui Yu, Chang-Fu Kuo, Ming-Shien Wen, Wei-Jan Chen, Yung-Hsin Yeh and Lai-Chu See
    Citation: Cardiovascular Diabetology 2014 13:123
    Content type: Original investigation Published on:

  2. Growing evidence demonstrates subtle left ventricular myocardial dysfunction in patients with metabolic syndrome (MetS), with central obesity, glucose intolerance and inflammation emerging as important contrib...

    Authors: Juan Serrano-Ferrer, Guillaume Walther, Edward Crendal, Agnès Vinet, Frédéric Dutheil, Geraldine Naughton, Bruno Lesourd, Robert Chapier, Daniel Courteix and Philippe Obert
    Citation: Cardiovascular Diabetology 2014 13:116
    Content type: Original investigation Published on:

  4. We previously demonstrated that older beagles have impaired whole body and myocardial insulin responsiveness (MIR), and that glucagon-like peptide-1 (GLP-1 [7–36] amide) improves MIR in young beagles with dila...

    Authors: Melissa Chen, Franca S Angeli, You-tang Shen and Richard P Shannon
    Citation: Cardiovascular Diabetology 2014 13:115
    Content type: Original investigation Published on:

  5. It has been reported that increased expression of UCP-2 in the vasculature may prevent the development of atherosclerosis in patients with increased production of reactive oxygen species, as in the diabetes, o...

    Authors: Almudena Gómez-Hernández, Liliana Perdomo, Natalia de las Heras, Nuria Beneit, Óscar Escribano, Yolanda F Otero, Carlos Guillén, Sabela Díaz-Castroverde, Beatriz Gozalbo-López, Victoria Cachofeiro, Vicente Lahera and Manuel Benito
    Citation: Cardiovascular Diabetology 2014 13:108
    Content type: Original investigation Published on:

  6. Sepsis is a common disease that continues to increase in incidence in the world. Diseases, such as diabetes mellitus, may make the situation worse. Diabetic patients are at increased risk for common infections...

    Authors: Jian Cai, Shuai Lu, Zheng Yao, Ya-Ping Deng, Ling-Di Zhang, Jia-Wen Yu, Guo-Fei Ren, Fu-Ming Shen and Guo-Jun Jiang
    Citation: Cardiovascular Diabetology 2014 13:106
    Content type: Original investigation Published on:

  7. Alpha glucosidase inhibitor (GI) attenuates postprandial hyperglycemia (PPH) and reduces the risk of cardiovascular events in patients with impaired glucose tolerance or type 2 diabetes. Dipeptidyl peptidase 4...

    Authors: Kazufumi Nakamura, Hiroki Oe, Hajime Kihara, Kenei Shimada, Shota Fukuda, Kyoko Watanabe, Tsutomu Takagi, Kei Yunoki, Toru Miyoshi, Kumiko Hirata, Junichi Yoshikawa and Hiroshi Ito
    Citation: Cardiovascular Diabetology 2014 13:110
    Content type: Original investigation Published on:

  8. Endothelial nitric oxide synthase (eNOS)-uncoupling links obesity-associated insulin resistance and type-II diabetes to the increased incidence of cardiovascular disease. Studies have indicated that increased ...

    Authors: Yi Yu, Angana G Rajapakse, Jean-Pierre Montani, Zhihong Yang and Xiu-Fen Ming
    Citation: Cardiovascular Diabetology 2014 13:113
    Content type: Original investigation Published on:

  9. Although obesity is still considered a risk factor in the development of cardiovascular disorders, recent studies suggested that it may also be associated with reduced morbidity and mortality, the so-called “o...

    Authors: Ruduwaan Salie, Barbara Huisamen and Amanda Lochner
    Citation: Cardiovascular Diabetology 2014 13:109
    Content type: Original investigation Published on:

  10. Circulating endothelial progenitor cells (EPCs) reflect endothelial repair capacity and may be a significant marker for the clinical outcomes of cardiovascular disease. While some high-dose statin treatments m...

    Authors: Liang-Yu Lin, Chin-Chou Huang, Jia-Shiong Chen, Tao-Cheng Wu, Hsin-Bang Leu, Po-Hsun Huang, Ting-Ting Chang, Shing-Jong Lin and Jaw-Wen Chen
    Citation: Cardiovascular Diabetology 2014 13:111
    Content type: Original investigation Published on:

  11. Hyperglycemia has been recognized as a primary factor in endothelial barrier dysfunction and in the development of micro- and macrovascular diseases associated with diabetes, but the underlying biochemical mec...

    Authors: Mehran Haidari, Wei Zhang, James T Willerson and Richard AF Dixon
    Citation: Cardiovascular Diabetology 2014 13:112
    Content type: Original investigation Published on:

  12. Hyperglycemia has been recognized as a primary factor in endothelial barrier dysfunction and in the development of micro- and macrovascular diseases associated with diabetes, but the underlying biochemical mec...

    Authors: Mehran Haidari, Wei Zhang, James T Willerson and Richard AF Dixon
    Citation: Cardiovascular Diabetology 2014 13:105
    Content type: Original investigation Published on:

  14. Women with gestational diabetes history are at increased risk for type 2 diabetes. They face specific challenges for behavioural changes, including childcare responsibilities. The aim of this study is to test ...

    Authors: Anne-Sophie Brazeau, Aaron Leong, Sara J Meltzer, Rani Cruz, Deborah DaCosta, Mary Hendrickson-Nelson, Lawrence Joseph and Kaberi Dasgupta
    Citation: Cardiovascular Diabetology 2014 13:104
    Content type: Original investigation Published on:

  16. Evidence concerning the importance of glucose lowering in the prevention of cardiovascular (CV) outcomes remains controversial. Given the multi-faceted pathogenesis of atherosclerosis in diabetes, it is likely...

    Authors: Bernard Zinman, Silvio E Inzucchi, John M Lachin, Christoph Wanner, Roberto Ferrari, David Fitchett, Erich Bluhmki, Stefan Hantel, Joan Kempthorne-Rawson, Jennifer Newman, Odd Erik Johansen, Hans-Juergen Woerle and Uli C Broedl
    Citation: Cardiovascular Diabetology 2014 13:102
    Content type: Study protocol Published on:

  17. Diabetic patients have a significantly worse prognosis after an acute myocardial infarction (AMI) than their counterparts. Previous studies have shown that the number of circulating endothelial progenitor cell...

    Authors: Natália António, Rosa Fernandes, Ana Soares, Francisco Soares, Ana Lopes, Tiago Carvalheiro, Artur Paiva, Guilherme Mariano Pêgo, Luís A Providência, Lino Gonçalves and Carlos Fontes Ribeiro
    Citation: Cardiovascular Diabetology 2014 13:101
    Content type: Original investigation Published on:

  18. Heart disease is the leading cause of death in diabetic patients, and defective copper metabolism may play important roles in the pathogenesis of diabetic cardiomyopathy (DCM). The present study sought to dete...

    Authors: Shaoping Zhang, Hong Liu, Greeshma V Amarsingh, Carlos C H Cheung, Sebastian Hogl, Umayal Narayanan, Lin Zhang, Selina McHarg, Jingshu Xu, Deming Gong, John Kennedy, Bernard Barry, Yee Soon Choong, Anthony R J Phillips and Garth J S Cooper
    Citation: Cardiovascular Diabetology 2014 13:100
    Content type: Original investigation Published on:

  19. Vascular endothelial dysfunction is involved in macrovascular disease progression in type 2 diabetes mellitus (T2DM). We reported previously that blood glucose fluctuations, as evaluated by continuous glucose ...

    Authors: Keiichi Torimoto, Yosuke Okada, Hiroko Mori and Yoshiya Tanaka
    Citation: Cardiovascular Diabetology 2014 13:99
    Content type: Original investigation Published on:

  20. Caffeic acid phenethyl ester (CAPE) has been shown to protect the heart against ischemia/reperfusion (I/R) injury by various mechanisms including its antioxidant effect. In this study, we evaluated the protect...

    Authors: Yi-Jin Ho, An-Sheng Lee, Wen-Pin Chen, Wei-Lung Chang, Ying-Kang Tsai, Hsi-Lin Chiu, Yueh-Hsiung Kuo and Ming-Jai Su
    Citation: Cardiovascular Diabetology 2014 13:98
    Content type: Original investigation Published on:

  21. Vascular smooth muscle cells (VSMCs) proliferation and migration, which are central in the development of vascular diseases, are regulated by numerous hormones and humoral factors. Activation of the insulin re...

    Authors: Changqing Yu, Zhen Wang, Yu Han, Yukai Liu, Wei Eric Wang, Caiyu Chen, Hongyong Wang, Pedro A Jose and Chunyu Zeng
    Citation: Cardiovascular Diabetology 2014 13:97
    Content type: Original investigation Published on:

  22. The dipeptidyl-peptidase-IV (DPP-4) inhibitors, including sitagliptin, are used for the treatment of type 2 diabetes mellitus (T2DM). Adiponectin, an adipocyte-derived circulating protein, has anti-atheroscler...

    Authors: Toshiyuki Hibuse, Norikazu Maeda, Ken Kishida, Takekazu Kimura, Tomoko Minami, Eriko Takeshita, Ayumu Hirata, Yasuhiko Nakagawa, Susumu Kashine, Akemi Oka, Masumi Hayashi, Hitoshi Nishizawa, Tohru Funahashi and Iichiro Shimomura
    Citation: Cardiovascular Diabetology 2014 13:96
    Content type: Original investigation Published on:

  24. We aimed to assess the safety and tolerability of different doses of canakinumab versus placebo in patients with type 2 diabetes mellitus (T2DM).

    Authors: Campbell Howard, Adele Noe, Andrej Skerjanec, Björn Holzhauer, Margaret Wernsing, Monica Ligueros-Saylan and Tom Thuren
    Citation: Cardiovascular Diabetology 2014 13:94
    Content type: Original investigation Published on:

  25. Metformin (MET) therapy exerts positive effects improving glucose tolerance and preventing the evolution toward diabetes in insulin resistant patients. It has been shown that adding MET to exercise training do...

    Authors: Christian Cadeddu, Silvio Nocco, Lucia Cugusi, Martino Deidda, Alessandro Bina, Orru Fabio, Stefano Bandinu, Efisio Cossu, Marco Giorgio Baroni and Giuseppe Mercuro
    Citation: Cardiovascular Diabetology 2014 13:93
    Content type: Original investigation Published on:

  26. Type 2 diabetes (T2D) is associated with reduction and dysfunction of circulating pro-angiogenic cells (PACs). DPP-4 inhibitors, a class of oral agents for T2D, might possess pleiotropic vasculoprotective acti...

    Authors: Nicol Poncina, Mattia Albiero, Lisa Menegazzo, Roberta Cappellari, Angelo Avogaro and Gian Paolo Fadini
    Citation: Cardiovascular Diabetology 2014 13:92
    Content type: Original investigation Published on:

  27. Angiotensin receptor blockers (ARBs) have been shown to exert various peroxisome proliferator-activated receptor gamma (PPARγ) binding activities and insulin-sensitizing effects. The objective of this study wa...

    Authors: Chia-Hsuin Chang, Yi-Cheng Chang, Li-Chiu Wu, Jou-Wei Lin, Lee-Ming Chuang and Mei-Shu Lai
    Citation: Cardiovascular Diabetology 2014 13:91
    Content type: Original investigation Published on:

  28. The genetic polymorphism concerning the ß3-subunit of platelet integrin receptor glycoprotein IIIa is held responsible for enhanced binding of adhesive proteins resulting in increased thrombogenic potential. W...

    Authors: Bernd Stratmann, Tao Xu, Christa Meisinger, Barbara Menart, Michael Roden, Christian Herder, Harald Grallert, Annette Peters, Wolfgang Koenig, Thomas Illig, Heinz-Erich Wichmann, Rui Wang-Sattler, Wolfgang Rathmann and Diethelm Tschoepe
    Citation: Cardiovascular Diabetology 2014 13:90
    Content type: Original investigation Published on:

  29. Despite advances in the treatment of heart failure, mortality remains high, particularly in individuals with diabetes. Activated transforming growth factor beta (TGF-β) contributes to the pathogenesis of the f...

    Authors: Antoinette Bugyei-Twum, Andrew Advani, Suzanne L Advani, Yuan Zhang, Kerri Thai, Darren J Kelly and Kim A Connelly
    Citation: Cardiovascular Diabetology 2014 13:89
    Content type: Original investigation Published on:

  30. The present study was to investigate the role of calpain in reactive oxygen species (ROS) production in endothelial cells and endothelium-dependent vascular dysfunction under experimental conditions of diabetes.

    Authors: Bainian Chen, Qing Zhao, Rui Ni, Futian Tang, Limei Shan, Inga Cepinskas, Gediminas Cepinskas, Wang Wang, Peter W Schiller and Tianqing Peng
    Citation: Cardiovascular Diabetology 2014 13:88
    Content type: Original investigation Published on:

  31. Intima-media thickness (IMT) of the common carotid artery is a surrogate end point of cardiovascular disease (CVD). Identifying the factors associated with a higher IMT may contribute to the identification of ...

    Authors: Carlos Roberto Moraes de Andrade Junior, Eliete Leão Clemente Silva, Maria de Fátima Bevilaqua da Matta, Marcia Bueno Castier, Maria Luiza Garcia Rosa and Marília de Brito Gomes
    Citation: Cardiovascular Diabetology 2014 13:87
    Content type: Original investigation Published on:

  32. Insulin resistance, as a key mediator of metabolic syndrome, is thought to be associated with pathogenesis of calcific aortic valve disease and altered left ventricular (LV) function and structure. However, in...

    Authors: Hiroto Utsunomiya, Hideya Yamamoto, Eiji Kunita, Takayuki Hidaka and Yasuki Kihara
    Citation: Cardiovascular Diabetology 2014 13:86
    Content type: Original investigation Published on:

  33. Matrix Gla protein (MGP) is an important inhibitor of calcification. The objective of the present study of patients with type 2 diabetes and normal or slightly altered kidney function was to evaluate levels of...

    Authors: Sophie Liabeuf, Bourron Olivier, Cees Vemeer, Elke Theuwissen, Elke Magdeleyns, Carole Elodie Aubert, Michel Brazier, Romuald Mentaverri, Agnes Hartemann and Ziad A Massy
    Citation: Cardiovascular Diabetology 2014 13:85
    Content type: Original investigation Published on:

    The Erratum to this article has been published in Cardiovascular Diabetology 2015 14:9

  34. Various adipokines are reported to be associated with the development of heart failure (HF) through insulin resistance and chronic inflammation. Omentin-1 is a novel adipokine and is associated with incident c...

    Authors: Taro Narumi, Tetsu Watanabe, Shinpei Kadowaki, Daisuke Kinoshita, Miyuki Yokoyama, Yuki Honda, Yoichiro Otaki, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto and Isao Kubota
    Citation: Cardiovascular Diabetology 2014 13:84
    Content type: Original investigation Published on:

  35. The presence of impaired glucose tolerance (IGT) and metabolic syndrome (MetS) are two risk factors for Type 2 diabetes. The inter-relatedness of these factors among adolescents is unclear.

    Authors: Mark D DeBoer and Matthew J Gurka
    Citation: Cardiovascular Diabetology 2014 13:83
    Content type: Original investigation Published on:

  36. Glycation of high-density lipoprotein (HDL) decreases its ability to induce cyclooxygenase-2 (COX-2) expression and prostacyclin I-2 (PGI-2) release in endothelial cells. Whether lipid content of HDL, especial...

    Authors: Xunliang Tong, Pu Lv, Anna V Mathew, Donghui Liu, Chenguang Niu, Yan Wang, Liang Ji, Jizhao Li, Zhiwei Fu, Bing Pan, Subramaniam Pennathur, Lemin Zheng and Yining Huang
    Citation: Cardiovascular Diabetology 2014 13:82
    Content type: Original investigation Published on:

  37. In the emerging landscape of cardiovascular (CV) outcome trials evaluating the effects of blood glucose lowering drugs in individuals with type 2 diabetes, it is becoming increasingly apparent that since the p...

    Authors: Eberhard Standl, Michael J Theodorakis, Michael Erbach, Oliver Schnell and Jaakko Tuomilehto
    Citation: Cardiovascular Diabetology 2014 13:81
    Content type: Review Published on:

  38. Pharmaceutical interventions for diabetes aim to control glycaemia and to prevent the development of complications, such as cardiovascular diseases. Some anti-hyperglycaemic drugs have been found to have adver...

    Authors: Sefaa Al-aryahi, Danielle Kamato, Robel Getachew, Wenhua Zheng, Simon J Potocnik, Neale Cohen, Daniel Guidone, Narin Osman and Peter J Little
    Citation: Cardiovascular Diabetology 2014 13:80
    Content type: Original investigation Published on:

  39. Diabetes induces numerous electrical, ionic and biochemical defects in the heart. A general feature of diabetic myocardium is its low rate of activity, commonly characterised by prolonged twitch duration. This...

    Authors: June-Chiew Han, Kenneth Tran, Poul MF Nielsen, Andrew J Taberner and Denis S Loiselle
    Citation: Cardiovascular Diabetology 2014 13:79
    Content type: Original investigation Published on:

  40. Rat neonate cardiomyocytes were cultured and treated with AGEs at different concentration. Two classic autophagy markers, microtubule-associated protein 1 light chain 3 (LC3) and Beclin-1, were detected by wes...

    Authors: Xuwei Hou, Zhaohui Hu, Hanying Xu, Jian Xu, Shunrong Zhang, Yigang Zhong, Xiuying He and Ningfu Wang
    Citation: Cardiovascular Diabetology 2014 13:78
    Content type: Original investigation Published on:

  41. Type 2 diabetes mellitus (T2DM) is a major cardiovascular disease (CVD) risk factor. Identification of genetic risk factors for CVD is important to understand disease risk. Two recent genome-wide association s...

    Authors: Jeremy N Adams, Laura M Raffield, Barry I Freedman, Carl D Langefeld, Maggie CY Ng, J Jeffrey Carr, Amanda J Cox and Donald W Bowden
    Citation: Cardiovascular Diabetology 2014 13:77
    Content type: Original investigation Published on:

  42. Cardiovascular diseases (CVD) are a leading cause of death worldwide including the Middle East. This is caused in part by the dysregulation of adipose tissue leading to increased production of pro-inflammatory...

    Authors: Mohamed Abu-Farha, Kazem Behbehani and Naser Elkum
    Citation: Cardiovascular Diabetology 2014 13:76
    Content type: Original investigation Published on:

  43. Cardiac dysfunction in diabetic cardiomyopathy may be associated with abnormal Ca2+ homeostasis. This study investigated the effects of alterations in Ca2+ homeostasis and sarcoplasmic reticulum Ca2+-associated p...

    Authors: Shu-Mei Zhao, Yong-Liang Wang, Chun-Yan Guo, Jin-Ling Chen and Yong-Quan Wu
    Citation: Cardiovascular Diabetology 2014 13:75
    Content type: Original investigation Published on:

  44. Recent studies have demonstrated a protective effect of osteocalcin (OCN) on glucose homeostasis and metabolic syndrome. However, its role in vascular function remains unknown. This study investigated the cont...

    Authors: Jianxin Dou, Huating Li, Xiaojing Ma, Mingliang Zhang, Qichen Fang, Meiyun Nie, Yuqian Bao and Weiping Jia
    Citation: Cardiovascular Diabetology 2014 13:74
    Content type: Original investigation Published on:

  45. Insulin resistance (IR) assessed by the Homeostatic Model Assessment (HOMA) index in the acute phase of myocardial infarction in non-diabetic patients was recently established as an independent predictor of in...

    Authors: Danijela Trifunovic, Sanja Stankovic, Dragana Sobic-Saranovic, Jelena Marinkovic, Marija Petrovic, Dejan Orlic, Branko Beleslin, Marko Banovic, Bosiljka Vujisic-Tesic, Milan Petrovic, Ivana Nedeljkovic, Jelena Stepanovic, Ana Djordjevic-Dikic, Milorad Tesic, Nina Djukanovic, Olga Petrovic…
    Citation: Cardiovascular Diabetology 2014 13:73
    Content type: Original investigation Published on:

  46. Diastolic dysfunction is a key factor in the development and pathology of cardiac dysfunction in diabetes, however the exact underlying mechanism remains unknown, especially in humans. We aimed to measure cont...

    Authors: Regis R Lamberts, Shivanjali J Lingam, Heng-Yu Wang, Ilse AE Bollen, Gillian Hughes, Ivor F Galvin, Richard W Bunton, Andrew Bahn, Rajesh Katare, J Chris Baldi, Michael JA Williams, Pankaj Saxena, Sean Coffey and Peter P Jones
    Citation: Cardiovascular Diabetology 2014 13:72
    Content type: Original investigation Published on:

  47. Postprandial elevation of triglyceride-rich lipoproteins impairs endothelial function, which can initiate atherosclerosis. We investigated the effects of bezafibrate on postprandial endothelial dysfunction and...

    Authors: Yuko Ohno, Toru Miyoshi, Yoko Noda, Hiroki Oe, Norihisa Toh, Kazufumi Nakamura, Kunihisa Kohno, Hiroshi Morita and Hiroshi Ito
    Citation: Cardiovascular Diabetology 2014 13:71
    Content type: Original investigation Published on:

  48. Although body mass index (BMI) is the most widely accepted parameter for defining obesity, recent studies have indicated a unique set of patients who exhibit normal BMI and excess body fat (BF), which is terme...

    Authors: Shinae Kang, Chanhee Kyung, Jong Suk Park, Sohee Kim, Seung-Pyo Lee, Min Kyung Kim, Hye Kyung Kim, Kyung Rae Kim, Tae Joo Jeon and Chul Woo Ahn
    Citation: Cardiovascular Diabetology 2014 13:70
    Content type: Original investigation Published on:

  49. It has been reported that GLP-1 agonist exenatide (exendin-4) decreases blood pressure. The dose-dependent vasodilator effect of exendin-4 has previously been demonstrated, although the precise mechanism is no...

    Authors: Eszter Sélley, Szilárd Kun, István András Szijártó, Boglárka Laczy, Tibor Kovács, Ferenc Fülöp, István Wittmann and Gergő A Molnár
    Citation: Cardiovascular Diabetology 2014 13:69
    Content type: Original investigation Published on:

  50. Diabetic women are five times more likely to develop congestive heart failure compared with two fold for men. The underlying mechanism for this gender difference is not known. Here we investigate the molecular...

    Authors: Andrew Moore, Amol Shindikar, Ingrid Fomison-Nurse, Federica Riu, Pujika E Munasinghe, Thrishila Parshu Ram, Pankaj Saxena, Sean Coffey, Richard W Bunton, Ivor F Galvin, Michael JA Williams, Costanza Emanueli, Paolo Madeddu and Rajesh Katare
    Citation: Cardiovascular Diabetology 2014 13:68
    Content type: Original investigation Published on:
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Cardiovascular Diabetology

ISSN: 1475-2840