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  1. Inflammation plays an important role in the pathophysiology of both atherosclerosis and type 2 diabetes and some inflammatory markers may also predict the risk of developing type 2 diabetes. The aims of the pr...

    Authors: Eva C Knudsen, Ingebjørg Seljeflot, Abdelnoor Michael, Jan Eritsland, Arild Mangschau, Carl Müller, Harald Arnesen and Geir Ø Andersen

    Citation: Cardiovascular Diabetology 2010 9:47

    Content type: Original investigation

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  2. Patients with metabolic syndrome (MetS) have an increased risk of cardiovascular disease. Data obtained from muscle biopsies have demonstrated altered insulin signaling (IS) in patients with MetS. The IS regul...

    Authors: Evasio Pasini, Vincenzo Flati, Silvia Paiardi, Damiano Rizzoni, Enzo Porteri, Roberto Aquilani, Deodato Assanelli, Giovanni Corsetti, Silvia Speca, Rita Rezzani, Carolina De Ciuceis and Enrico Agabiti-Rosei

    Citation: Cardiovascular Diabetology 2010 9:46

    Content type: Original investigation

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  3. Although diabetic patients have an increased rate of cardio-vascular events, there is considerable heterogeneity with respect to cardiovascular risk, requiring new approaches to individual cardiovascular risk ...

    Authors: Hannes M Findeisen, Sabine Weckbach, Renée G Stark, Maximilian F Reiser, Stefan O Schoenberg and Klaus G Parhofer

    Citation: Cardiovascular Diabetology 2010 9:44

    Content type: Original investigation

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  4. The mechanisms responsible for the cardiovascular mortality in type I diabetes (DM) have not been defined completely. We have shown in conscious dogs with DM that: 1) baseline coronary blood flow (CBF) was signif...

    Authors: Caroline Ojaimi, Shintaro Kinugawa, Fabio A Recchia and Thomas H Hintze

    Citation: Cardiovascular Diabetology 2010 9:43

    Content type: Original investigation

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  5. The beta-1 adrenergic receptor (β1AR) plays a fundamental role in the regulation of cardiovascular functions. It carries a nonsynonymous single nucleotide polymorphism in its carboxyl terminal tail (Arg389Gly), w...

    Authors: Anna E Hakalahti, Jari M Tapanainen, Juhani M Junttila, Kari S Kaikkonen, Heikki V Huikuri and Ulla E Petäjä-Repo

    Citation: Cardiovascular Diabetology 2010 9:42

    Content type: Original investigation

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  6. Accumulation of oxidized low-density lipoproteins in the intimae of arteries and endothelial dysfunction are key events in the development of atherosclerosis. Patients with metabolic syndrome are at high risk ...

    Authors: Hanna Pohjantähti-Maaroos, Ari Palomäki, Päivi Kankkunen, Ruth Laitinen, Sari Husgafvel and Kalevi Oksanen

    Citation: Cardiovascular Diabetology 2010 9:41

    Content type: Original investigation

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  7. The use of carotid intima-media thickness (carotid IMT) as a surrogate marker of cardiovascular disease is increasing and the method has now also been applied in several trials investigating patients with type...

    Authors: Louise Lundby-Christensen, Thomas P Almdal, Bendix Carstensen, Lise Tarnow and Niels Wiinberg

    Citation: Cardiovascular Diabetology 2010 9:40

    Content type: Methodology

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  8. C-reactive protein (CRP), a biomarker of inflammation, has been associated with increased risk of developing cardiovascular disease. Common variants of the hepatocyte nuclear factor 1A (HNF1A) gene encoding HNF-1...

    Authors: Sylvia H Ley, Robert A Hegele, Philip W Connelly, Stewart B Harris, Mary Mamakeesick, Henian Cao, Joel Gittelsohn, Ravi Retnakaran, Bernard Zinman and Anthony J Hanley

    Citation: Cardiovascular Diabetology 2010 9:39

    Content type: Original investigation

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  9. Studies focusing on the add-on effects of angiotensin II type 1 receptor blockers (ARBs) other than their antihypertensive effect are receiving attention. However, the effects of prolonged administration of AR...

    Authors: Yayoi Nishida, Yasuo Takahashi, Tomohiro Nakayama, Masayoshi Soma, Noboru Kitamura and Satoshi Asai

    Citation: Cardiovascular Diabetology 2010 9:38

    Content type: Original investigation

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  10. Hypertensive patients with reduced blood pressure fall (BPF) at night are at higher risk of cardiovascular events (CVE).

    Authors: João S Felício, Ana Carolina CB de Souza, Nárcia Kohlmann, Oswaldo Kohlmann Jr, Arthur B Ribeiro and Maria T Zanella

    Citation: Cardiovascular Diabetology 2010 9:36

    Content type: Original investigation

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  11. Four single nucleotide polymorphisms (SNPs) (rs2237892, rs2237895, rs2237897, and rs2283228) in KCNQ1 are reported to be associated with type 2 diabetes mellitus (T2DM), possibly caused by a reduction in insulin ...

    Authors: Zhong Chen, Quanzhong Yin, Genshan Ma and Qi Qian

    Citation: Cardiovascular Diabetology 2010 9:35

    Content type: Original investigation

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  12. Based on the AHA/NHLBI-definition three out of five cardiometabolic traits must be present for the diagnosis of the metabolic syndrome (MetS), resulting in 16 different combination types. The associated cardio...

    Authors: Susanne Moebus, Chakrapani Balijepalli, Christian Lösch, Laura Göres, Bernd von Stritzky, Peter Bramlage, Jürgen Wasem and Karl-Heinz Jöckel

    Citation: Cardiovascular Diabetology 2010 9:34

    Content type: Original investigation

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  13. We sought to explore the association of variant rs1333049 on chromosome 9p21.3 with coronary artery disease (CAD) and angiographic plaque progression in non-diabetic and type 2 diabetic patients.

    Authors: Wei Wang, Wenhui Peng, Xianling Zhang, Lin Lu, Ruiyan Zhang, Qi Zhang, Lingjie Wang, Qiujing Chen and Weifeng Shen

    Citation: Cardiovascular Diabetology 2010 9:33

    Content type: Original investigation

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  14. Activation of glucagon-like peptide-1 (GLP-1) receptors improves insulin sensitivity and induces vasodilatation and diuresis. AC3174 is a peptide analogue with pharmacologic properties similar to the GLP-1 rec...

    Authors: Que Liu, Lisa Adams, Anatoly Broyde, Rayne Fernandez, Alain D Baron and David G Parkes

    Citation: Cardiovascular Diabetology 2010 9:32

    Content type: Original investigation

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  15. Substantial evidence suggests that high glucose (HG) causes endothelial cell damage; however, the potential mechanism therein has yet to be clarified. The aim of this study was to investigate the influence of ...

    Authors: Rining Tang, Qing Li, Linli Lv, Houyong Dai, Min Zheng, Kunling Ma and Bicheng Liu

    Citation: Cardiovascular Diabetology 2010 9:31

    Content type: Original investigation

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  16. Metabolic syndrome (MetS) is frequently characterized by elevated liver enzymes, including gamma-glutamyl transferase (GGT) and alanine aminotransferase (ALT). Our objective was to evaluate the range of preval...

    Authors: Arie Steinvil, Itzhak Shapira, Orit Kliuk Ben-Bassat, Michael Cohen, Yaffa Vered, Shlomo Berliner and Ori Rogowski

    Citation: Cardiovascular Diabetology 2010 9:30

    Content type: Original investigation

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  17. In a previous study, we demonstrated that the thickness of epicardial adipose tissue (EAT), measured by echocardiography, was increased in patients with metabolic syndrome (MS) and coronary artery disease (CAD...

    Authors: Jin-Sun Park, Sung-Gyun Ahn, Jung-Won Hwang, Hong-Seok Lim, Byoung-Joo Choi, So-Yeon Choi, Myeong-Ho Yoon, Gyo-Seung Hwang, Seung-Jea Tahk and Joon-Han Shin

    Citation: Cardiovascular Diabetology 2010 9:29

    Content type: Original investigation

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  18. The purpose of this study was to test the hypothesis that sidestream tobacco smoke extracts would inhibit the culture of endothelial cells and enhance platelet aggregation under diabetic vascular conditions. S...

    Authors: David A Rubenstein, Blake E Morton and Wei Yin

    Citation: Cardiovascular Diabetology 2010 9:28

    Content type: Original investigation

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  19. Insulin resistance (IR) and related metabolic disturbances are characterized by low levels of adiponectin. High molecular weight adiponectin (HMWA) is considered the active form of adiponectin and a better mar...

    Authors: Paloma Almeda-Valdes, Daniel Cuevas-Ramos, Roopa Mehta, Francisco J Gomez-Perez, Ivette Cruz-Bautista, Olimpia Arellano-Campos, Mariana Navarrete-Lopez and Carlos A Aguilar-Salinas

    Citation: Cardiovascular Diabetology 2010 9:26

    Content type: Original investigation

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  20. In patients with myocardial infarction or heart failure, right ventricular (RV) dysfunction is associated with death, shock and arrhythmias. In patients with type 2 diabetes mellitus, structural and functional...

    Authors: Charissa E van den Brom, Joanna WAM Bosmans, Ronald Vlasblom, Louis M Handoko, Marc C Huisman, Mark Lubberink, Carla FM Molthoff, Adriaan A Lammertsma, Margriet D Ouwens, Michaela Diamant and Christa Boer

    Citation: Cardiovascular Diabetology 2010 9:25

    Content type: Original investigation

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  21. Diabetes is a major challenge for the health care system and especially for the primary care provider. The Chronic Care Model represents an evidence-based framework for the care for chronically ill. An increas...

    Authors: Anja Frei, Corinne Chmiel, Hansueli Schläpfer, Beatrice Birnbaum, Ulrike Held, Johann Steurer and Thomas Rosemann

    Citation: Cardiovascular Diabetology 2010 9:23

    Content type: Study protocol

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  22. Studies of beta blockade in patients with type 2 diabetes have shown inferiority of metoprolol treatment compared to carvedilol on indices of insulin resistance. The aim of this study was to examine the effect...

    Authors: Britt Kveiborg, Thomas S Hermann, Atheline Major-Pedersen, Buris Christiansen, Christian Rask-Madsen, Jakob Raunsø, Lars Køber, Christian Torp-Pedersen and Helena Dominguez

    Citation: Cardiovascular Diabetology 2010 9:21

    Content type: Original investigation

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  23. The primary goal of therapy in patients with hypercholesterolemia and coronary heart disease (CHD) is reducing low-density lipoprotein cholesterol (LDL-C). This was a multicenter, randomized, double-blind, dou...

    Authors: Gianluca Bardini, Carlo B Giorda, Antonio E Pontiroli, Cristina Le Grazie and Carlo M Rotella

    Citation: Cardiovascular Diabetology 2010 9:20

    Content type: Original investigation

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  24. Endothelial dysfunction precedes atherogenesis and clinical complications in type 2 diabetes. The vascular dysfunction in Zucker diabetic fatty (ZDF) rats was evaluated at different ages along with the effect ...

    Authors: Xiao Lu, Xiaomei Guo, Sotirios K Karathanasis, Karen M Zimmerman, Jude E Onyia, Richard G Peterson and Ghassan S Kassab

    Citation: Cardiovascular Diabetology 2010 9:19

    Content type: Original investigation

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  25. To study the relationship between the intima-media thickness (IMT) of the carotid artery and the stage of chronic kidney disease (CKD) based on the estimated glomerular filtration rate (eGFR) and diabetic neph...

    Authors: Hiroyuki Ito, Yuko Komatsu, Mizuo Mifune, Shinichi Antoku, Hidenori Ishida, Yuichiro Takeuchi and Michiko Togane

    Citation: Cardiovascular Diabetology 2010 9:18

    Content type: Original investigation

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  26. Glucagon-like peptide-1 (GLP-1) is an incretin hormone that has a wide range of effects on glucose metabolism and cardiovascular function (e.g., improving insulin sensitivity, reduction in appetite, modulation...

    Authors: Minako Yamaoka-Tojo, Taiki Tojo, Naonobu Takahira, Atsuhiko Matsunaga, Naoyoshi Aoyama, Takashi Masuda and Tohru Izumi

    Citation: Cardiovascular Diabetology 2010 9:17

    Content type: Original investigation

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  27. To evaluate glycemic variability associated with two different premixed insulin analogue formulations when used in a twice-daily regimen.

    Authors: Rimei Nishimura, Daisuke Tsujino, Kentaro Taki, Aya Morimoto and Naoko Tajima

    Citation: Cardiovascular Diabetology 2010 9:16

    Content type: Original investigation

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  28. Although there is a growing body of evidence showing that patients with type 2 diabetes mellitus (T2DM) have poor glycemic control in general, it is not clear whether T2DM patients with pre-existing cardiovasc...

    Authors: Alex Z Fu, Ying Qiu, Larry Radican, Donald D Yin and Panagiotis Mavros

    Citation: Cardiovascular Diabetology 2010 9:15

    Content type: Original investigation

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  29. Many studies on diabetes have demonstrated that an intensive control of glycaemia and the main associated risk factors (hypertension, dislipidaemia, obesity and smoking) reduce cardiovascular morbi-mortality. ...

    Authors: Lucas Mengual, Pilar Roura, Marta Serra, Montserrat Montasell, Gemma Prieto and Sandra Bonet

    Citation: Cardiovascular Diabetology 2010 9:14

    Content type: Original investigation

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  30. Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor, which regulates gene expression of the key proteins involved in lipid metabolism, vascular inflammation, and pro...

    Authors: Jing Wan, Shixi Xiong, Shengping Chao, Jianming Xiao, Yexin Ma, Jinghua Wang and Sabita Roy

    Citation: Cardiovascular Diabetology 2010 9:13

    Content type: Original investigation

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  31. Postprandial hyperglycemia is believed to affect vascular endothelial function. The aim of our study was to compare the effects of acarbose and nateglinide on postprandial endothelial dysfunction.

    Authors: Toru Kato, Teruo Inoue and Koichi Node

    Citation: Cardiovascular Diabetology 2010 9:12

    Content type: Original investigation

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  32. The metabolic syndrome is thought to be associated with a chronic low-grade inflammation, and a growing body of evidence suggests that interleukin-18 (IL-18) might be closely related to the metabolic syndrome ...

    Authors: Marius Trøseid, Ingebjørg Seljeflot and Harald Arnesen

    Citation: Cardiovascular Diabetology 2010 9:11

    Content type: Review

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  33. Adiponectin is an adipose tissue secreted protein known for its insulin sensitising and anti-atherogenic actions. To this date two adiponectin receptors have been discovered, adiponectin receptor 1 (ADIPOR1) a...

    Authors: Iosif Halvatsiotis, Panayoula C Tsiotra, Ignatios Ikonomidis, Anastasios Kollias, Panagiota Mitrou, Eirini Maratou, Eleni Boutati, John Lekakis, George Dimitriadis, Theofanis Economopoulos, Dimitrios T Kremastinos and Sotirios A Raptis

    Citation: Cardiovascular Diabetology 2010 9:10

    Content type: Original investigation

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  34. CVD in obesity and T2DM are associated with endothelial activation, elevated plasma vascular inflammation markers and a prothrombotic state. We examined the contribution of FFA to these abnormalities following...

    Authors: Manoj Mathew, Eric Tay and Kenneth Cusi

    Citation: Cardiovascular Diabetology 2010 9:9

    Content type: Original investigation

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  35. Diminished calcium (Ca2+) transients in response to physiological agonists have been reported in vascular smooth muscle cells (VSMCs) from diabetic animals. However, the mechanism responsible was unclear.

    Authors: Yvonne M Searls, Rajprasad Loganathan, Irina V Smirnova and Lisa Stehno-Bittel

    Citation: Cardiovascular Diabetology 2010 9:8

    Content type: Original investigation

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  36. This cross-sectional study sought to determine the prevalence of cardiometabolic risk factor clusters (CMRFCs) and their effect on BP control among hypertensive patients from 28 US physician practices.

    Authors: Daniel A Belletti, Christopher Zacker and Jenifer Wogen

    Citation: Cardiovascular Diabetology 2010 9:7

    Content type: Original investigation

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  37. Cardiovascular effects of glucose-lowering agents are of increasing interest. Our aim was to assess the effects of the glucagon-like peptide-1 receptor agonist exenatide on heart rate (HR) and blood pressure (...

    Authors: Anne Gill, Byron J Hoogwerf, Jude Burger, Simon Bruce, Leigh MacConell, Ping Yan, Daniel Braun, Joseph Giaconia and James Malone

    Citation: Cardiovascular Diabetology 2010 9:6

    Content type: Original investigation

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  38. Diabetes is associated with changes in myocardial stress-response pathways and is recognized as an independent risk factor for cardiac remodeling. Using spontaneously diabetic Goto Kakizaki rats as a model of ...

    Authors: Erik Vahtola, Marjut Louhelainen, Hanna Forstén, Saara Merasto, Johanna Raivio, Petri Kaheinen, Ville Kytö, Ilkka Tikkanen, Jouko Levijoki and Eero Mervaala

    Citation: Cardiovascular Diabetology 2010 9:5

    Content type: Original investigation

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  39. The aim of this study was to determine whether South Asian patients with diabetes have a worse prognosis following hospitalization for acute myocardial infarction (AMI) compared with their White counterparts. ...

    Authors: Aman PK Nijjar, Hong Wang, Kaberi Dasgupta, Doreen M Rabi, Hude Quan and Nadia A Khan

    Citation: Cardiovascular Diabetology 2010 9:4

    Content type: Original investigation

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  40. Patients with diabetes mellitus (DM) have high risk of heart failure. Whether some of the risk is directly linked to metabolic derangements in the myocardium or whether the risk is primarily caused by coronary...

    Authors: Charlotte Andersson, Gunnar H Gislason, Peter Weeke, Søren Hoffmann, Peter R Hansen, Christian Torp-Pedersen and Peter Søgaard

    Citation: Cardiovascular Diabetology 2010 9:3

    Content type: Original investigation

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  41. The aims of this study were to estimate the prevalence of left ventricular systolic (LVSD) and diastolic (LVDD) dysfunction, and to test if BNP and urinary albumin excretion rate (AER) are related to LVSD, LVD...

    Authors: Martin Magnusson, Stefan Jovinge, Kambiz Shahgaldi, Bo Israelsson, Leif Groop and Olle Melander

    Citation: Cardiovascular Diabetology 2010 9:2

    Content type: Original investigation

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  42. The long-term prognosis of diabetic patients with acute myocardial infarction (AMI) treated by acute revascularization is uncertain, and the optimal pharmacotherapy for such cases has not been fully evaluated.

    Authors: Ayako Takara, Hiroshi Ogawa, Yasuhiro Endoh, Fumiaki Mori, Jun-ichi Yamaguchi, Atsushi Takagi, Ryo Koyanagi, Tsuyoshi Shiga, Hiroshi Kasanuki and Nobuhisa Hagiwara

    Citation: Cardiovascular Diabetology 2010 9:1

    Content type: Original investigation

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  43. Dysfunctionally uncoupled endothelial nitric oxide synthase (eNOS) is involved in producing reactive oxygen species (ROS) in the diabetic endothelium. The present study investigated whether anti-diabetes drug ...

    Authors: Jeong-Ho Oak, Ji-Youn Youn and Hua Cai

    Citation: Cardiovascular Diabetology 2009 8:65

    Content type: Original investigation

    Published on:

  44. Vascular smooth muscular cells (VSMC) express lipogenic genes. Therefore in situ lipogenesis could provide fatty acids for triglycerides synthesis and cholesterol esterification and contribute to lipid accumulati...

    Authors: Nadjiba Hamlat, Fabien Forcheron, Samia Negazzi, Peggy del Carmine, Patrick Feugier, Giampiero Bricca, Souhila Aouichat-Bouguerra and Michel Beylot

    Citation: Cardiovascular Diabetology 2009 8:64

    Content type: Original investigation

    Published on:

  45. Hepatocyte nuclear factor 4α (HNF4α) is a nuclear receptor involved in glucose homeostasis and is required for normal β cell function. Mutations in the HNF4α gene are associated with maturity onset diabetes of...

    Authors: Seyed Morteza Taghavi, Seyedeh Seddigheh Fatemi, Houshang Rafatpanah, Rashin Ganjali, Jalil Tavakolafshari and Narges Valizadeh

    Citation: Cardiovascular Diabetology 2009 8:63

    Content type: Original investigation

    Published on:

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