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  1. Content type: Original investigation

    Obesity is associated with type 2 diabetes mellitus, left ventricular diastolic dysfunction and heart failure but it is unclear to which extent it is related to left ventricular systolic dysfunction. The aim o...

    Authors: Peter Blomstrand, Peter Sjöblom, Mats Nilsson, Magnus Wijkman, Martin Engvall, Toste Länne, Fredrik H. Nyström, Carl Johan Östgren and Jan Engvall

    Citation: Cardiovascular Diabetology 2018 17:113

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  2. Content type: Original investigation

    Although obesity-related type 2 diabetes mellitus (T2DM) and sarcopenia in the elderly have been increasing worldwide, the associations among visceral fat accumulation, skeletal muscle indices (mass, strength,...

    Authors: Jun Murai, Hitoshi Nishizawa, Akihito Otsuka, Shiro Fukuda, Yoshimitsu Tanaka, Hirofumi Nagao, Yasuna Sakai, Masahide Suzuki, Shinji Yokota, Hidetoshi Tada, Mayumi Doi, Yuya Fujishima, Shunbun Kita, Tohru Funahashi, Norikazu Maeda, Tadashi Nakamura…

    Citation: Cardiovascular Diabetology 2018 17:112

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  3. Content type: Original investigation

    Metabolic disorders such as obesity, insulin resistance and type 2 diabetes mellitus (DM2) are all linked to diabetic cardiomyopathy that lead to heart failure. Cardiomyopathy is initially characterized by car...

    Authors: Maayan Waldman, Keren Cohen, Dor Yadin, Vadim Nudelman, Dan Gorfil, Michal Laniado-Schwartzman, Ran Kornwoski, Dan Aravot, Nader G. Abraham, Michael Arad and Edith Hochhauser

    Citation: Cardiovascular Diabetology 2018 17:111

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    The Correction to this article has been published in Cardiovascular Diabetology 2018 17:115

  4. Content type: Original investigation

    Cardiovascular disease and kidney damage are tightly associated in people with type 2 diabetes. Experimental evidence supports a causal role for vasopressin (or antidiuretic hormone) in the development of diab...

    Authors: Gilberto Velho, Stéphanie Ragot, Ray El Boustany, Pierre-Jean Saulnier, Mathilde Fraty, Kamel Mohammedi, Frédéric Fumeron, Louis Potier, Michel Marre, Samy Hadjadj and Ronan Roussel

    Citation: Cardiovascular Diabetology 2018 17:110

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  5. Content type: Original investigation

    Arterial stiffness is emerging as an independent risk factor for the development of chronic kidney disease. The sodium glucose co-transporter 2 (SGLT2) inhibitors, which lower serum glucose by inhibiting SGLT2...

    Authors: Annayya R. Aroor, Nitin A. Das, Andrea J. Carpenter, Javad Habibi, Guanghong Jia, Francisco I. Ramirez-Perez, Luis Martinez-Lemus, Camila M. Manrique-Acevedo, Melvin R. Hayden, Cornel Duta, Ravi Nistala, Eric Mayoux, Jaume Padilla, Bysani Chandrasekar and Vincent G. DeMarco

    Citation: Cardiovascular Diabetology 2018 17:108

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  6. Content type: Original investigation

    The excess risks of mortality and cardiovascular morbidity among patients with type 2 diabetes mellitus (T2DM) is well known. In this nationwide study, we assessed risks of mortality and cardiovascular events ...

    Authors: Zoltán Kiss, György Rokszin, Zsolt Abonyi-Tóth, György Jermendy, Péter Kempler, Dániel Aradi and István Wittmann

    Citation: Cardiovascular Diabetology 2018 17:107

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  7. Content type: Original investigation

    Sodium glucose co-transporter2 inhibitors reduce the incidence of cardiovascular events in patients with type 2 diabetes mellitus based on the results of recent cardiovascular outcome studies. Herein, we inves...

    Authors: Νarjes Nasiri-Ansari, Georgios K. Dimitriadis, Georgios Agrogiannis, Despoina Perrea, Ioannis D. Kostakis, Gregory Kaltsas, Athanasios G. Papavassiliou, Harpal S. Randeva and Eva Kassi

    Citation: Cardiovascular Diabetology 2018 17:106

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  8. Content type: Original investigation

    Antioxidant enzymes play a fundamental role in counteracting oxidative stress induced by high glucose. Although mitochondrial superoxide dismutase (SOD2) is the principal defence against the toxicity of supero...

    Authors: Lucia La Sala, Simona Mrakic-Sposta, Stefano Micheloni, Francesco Prattichizzo and Antonio Ceriello

    Citation: Cardiovascular Diabetology 2018 17:105

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  9. Content type: Original investigation

    Oxidative stress (OS) plays an important role in type 2 diabetes (T2D) pathogenesis and its complications. New therapies target natural antioxidants as an alternative and/or supplemental strategy to prevent an...

    Authors: Remmelt Van der Werf, Catherine Walter, William Bietiger, Elodie Seyfritz, Carole Mura, Claude Peronet, Julie Legrandois, Dalal Werner, Said Ennahar, Fabien Digel, Elisa Maillard-Pedracini, Michel Pinget, Nathalie Jeandidier, Eric Marchioni, Séverine Sigrist and Stéphanie Dal

    Citation: Cardiovascular Diabetology 2018 17:104

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  10. Content type: Original investigation

    The cardiac hormones atrial (ANP) and B-type natriuretic peptides (BNP) moderate arterial blood pressure and improve energy metabolism as well as insulin sensitivity via their shared cGMP-producing guanylyl cy...

    Authors: Sabine Tauscher, Hitoshi Nakagawa, Katharina Völker, Franziska Werner, Lisa Krebes, Tamara Potapenko, Sören Doose, Andreas L. Birkenfeld, Hideo A. Baba and Michaela Kuhn

    Citation: Cardiovascular Diabetology 2018 17:103

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  11. Content type: Original investigation

    Incretin-based therapies including dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon like peptide-1 (GLP-1) receptor agonists are novel medications for type 2 diabetes management. Several studies have fou...

    Authors: Ghadeer K. Dawwas, Steven M. Smith and Haesuk Park

    Citation: Cardiovascular Diabetology 2018 17:102

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  12. Content type: Original investigation

    Hypertriglyceridemia, insulin resistance and hyperglycemia are risk factors for atherosclerosis in type 2 diabetes. Angiopoietin-like protein 8 (ANGPTL8) is a newly identified liver-derived hormone related to ...

    Authors: Tianpeng Zheng, Bo Ge, Hongbo Liu, Bo Chen, Linyuan Qin, Liuping Xiao and Jianfei Song

    Citation: Cardiovascular Diabetology 2018 17:84

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  13. Content type: Review

    Diabetes mellitus currently affects over 350 million patients worldwide and is associated with many deaths from cardiovascular complications. Sodium–glucose co-transporter 2 (SGLT-2) inhibitors are a novel cla...

    Authors: Sarayut Lahnwong, Siriporn C. Chattipakorn and Nipon Chattipakorn

    Citation: Cardiovascular Diabetology 2018 17:101

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  14. Content type: Original investigation

    The relationship between long-term glycemic variability (GV) represented by visit-to-visit HbA1c variability and baroreflex sensitivity (BRS) in type 2 diabetes mellitus (T2DM) has not been clarified by previo...

    Authors: Daisuke Matsutani, Masaya Sakamoto, Soichiro Minato, Yosuke Kayama, Norihiko Takeda, Ryuzo Horiuchi and Kazunori Utsunomiya

    Citation: Cardiovascular Diabetology 2018 17:100

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  15. Content type: Original investigation

    Inhibiting both type 1 and 2 sodium–glucose linked cotransporter (SGLT1/2) offers the potential to not only increase glucosuria beyond that seen with selective SGLT2 inhibition alone but to reduce glucose abso...

    Authors: Kim A. Connelly, Yanling Zhang, Jean-François Desjardins, Kerri Thai and Richard E. Gilbert

    Citation: Cardiovascular Diabetology 2018 17:99

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  16. Content type: Review

    Randomized controlled trials (RCTs) suggest that supplementation with omega-3 polyunsaturated fatty acids (n-3PUFAs) may favourably modify cardiometabolic biomarkers in type 2 diabetes (T2DM). Previous meta-an...

    Authors: Lauren L. O’Mahoney, Jamie Matu, Oliver J. Price, Karen M. Birch, Ramzi A. Ajjan, Diane Farrar, Robyn Tapp, Daniel J. West, Kevin Deighton and Matthew D. Campbell

    Citation: Cardiovascular Diabetology 2018 17:98

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  17. Content type: Original investigation

    The aim of the present study was to examine the association of angiopoietin-like proteins-8 (ANGPTL8) rs2278426, cholesteryl ester-transfer protein (CETP) rs708272 and endothelial nitric oxide synthase (NOS3) rs1...

    Authors: Dalia El-Lebedy

    Citation: Cardiovascular Diabetology 2018 17:97

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  18. Content type: Original investigation

    The prognostic impact of long-term glycemic variability on clinical outcomes in patients with heart failure (HF) and type 2 diabetes mellitus (T2DM) remains unclear. We determined and compared hemoglobin A1c (...

    Authors: Jun Gu, Jian-an Pan, Yu-qi Fan, Hui-li Zhang, Jun-feng Zhang and Chang-qian Wang

    Citation: Cardiovascular Diabetology 2018 17:96

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  19. Content type: Original investigation

    As body fat composition and metabolism differ between men and women, we evaluated sex-related differences in the association among epicardial adipose tissue (EAT), secretome profile, and myocardial function of...

    Authors: Dong-Hyuk Cho, Hyung Joon Joo, Mi-Na Kim, Do-Sun Lim, Wan Joo Shim and Seong-Mi Park

    Citation: Cardiovascular Diabetology 2018 17:95

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  20. Content type: Review

    Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug metformin and a cholesterol-lowering statin. However, b...

    Authors: Mariël F. van Stee, Albert A. de Graaf and Albert K. Groen

    Citation: Cardiovascular Diabetology 2018 17:94

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  21. Content type: Original investigation

    Previous studies have documented that visceral adipose tissue is positively associated with the risk of diabetes. However, the association of subcutaneous adipose tissue with diabetes risk is still in dispute....

    Authors: Peizhu Chen, Xuhong Hou, Gang Hu, Li Wei, Lei Jiao, Hongmei Wang, Siyu Chen, Jingzhu Wu, Yuqian Bao and Weiping Jia

    Citation: Cardiovascular Diabetology 2018 17:93

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  22. Content type: Original investigation

    Angiopoietin-like protein 8 (ANGPTL8), which is a novel hormone produced in liver and adipose tissue, is involved in regulating lipid metabolism. Patients with diabetes and coronary artery disease (CAD) have r...

    Authors: Xiaolu Jiao, Jiqiang He, Yunyun Yang, Song Yang, Juan Li and Yanwen Qin

    Citation: Cardiovascular Diabetology 2018 17:92

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  23. Content type: Original investigation

    Recently, two large randomized controlled trials which only included patients with underlying cardiovascular disease (CVD) or patients at high risk for CVD showed that two sodium glucose co-transporter 2 inhib...

    Authors: Young-Gun Kim, Seung Jin Han, Dae Jung Kim, Kwan-Woo Lee and Hae Jin Kim

    Citation: Cardiovascular Diabetology 2018 17:91

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  24. Content type: Original investigation

    Raised hemoglobinA1c (HbA1c) is an indicator of pre-diabetes, which is associated with increased risk of coronary artery disease. However, the detailed morphological characteristics of non-culprit plaques in a...

    Authors: Shaotao Zhang, Jiannan Dai, Haibo Jia, Sining Hu, Hongwei Du, Ning Li, Yongpeng Zou, Yanan Zou, Shenhong Jing, Yan Wang, Rong Sun and Bo Yu

    Citation: Cardiovascular Diabetology 2018 17:90

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  25. Content type: Original investigation

    Calcium/calmodulin-dependent kinase II-delta (CaMKIIδ) activity is enhanced during hyperglycemia and has been shown to alter intracellular calcium handling in cardiomyocytes, ultimately leading to reduced card...

    Authors: Lorna J. Daniels, Rachel S. Wallace, Olivia M. Nicholson, Genevieve A. Wilson, Fiona J. McDonald, Peter P. Jones, J. Chris Baldi, Regis R. Lamberts and Jeffrey R. Erickson

    Citation: Cardiovascular Diabetology 2018 17:89

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  26. Content type: Original investigation

    Local, abdominal fat depots may be related to alterations in cardiac function and morphology due to a metabolic linkage. Thus, we aimed to determine their association with subtle cardiac changes and the potent...

    Authors: Christopher L. Schlett, Roberto Lorbeer, Carolyn Arndt, Sigrid Auweter, Jürgen Machann, Holger Hetterich, Birgit Linkohr, Wolfgang Rathmann, Annette Peters and Fabian Bamberg

    Citation: Cardiovascular Diabetology 2018 17:88

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  27. Content type: Original investigation

    Chronic low-grade inflammation and associated insulin resistance and metabolic abnormalities have been proposed as ‘common soil’ for diabetes mellitus (DM) and cardiovascular disease (CVD). This paper aimed to...

    Authors: Xue Bao, Yan Borné, Linda Johnson, Iram Faqir Muhammad, Margaretha Persson, Kaijun Niu and Gunnar Engström

    Citation: Cardiovascular Diabetology 2018 17:87

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  28. Content type: Study protocol

    Recent studies reported that sodium glucose cotransporter 2 (SGLT2) inhibitors reduced the cardiovascular morbidity and mortality in patients with type 2 diabetes mellitus (T2DM) compared to placebo in contras...

    Authors: Fumika Shigiyama, Naoki Kumashiro, Ayako Fuchigami and Takahisa Hirose

    Citation: Cardiovascular Diabetology 2018 17:86

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  29. Content type: Commentary

    Recent clinical trials investigating cardiovascular (CV) safety of newer antidiabetic agents have been rapidly and largely changing the landscape of diabetes care and providing highly important clinical inform...

    Authors: Atsushi Tanaka and Koichi Node

    Citation: Cardiovascular Diabetology 2018 17:85

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  30. Content type: Original investigation

    Advanced glycation end-products play a role in diabetic vascular complications. Their optical properties allow to estimate their accumulation in tissues by measuring the skin autofluorescence (SAF). We searche...

    Authors: C. Blanc-Bisson, F. L. Velayoudom-Cephise, A. Cougnard-Gregoire, C. Helmer, K. Rajaobelina, C. Delcourt, L. Alexandre, L. Blanco, K. Mohammedi, M. Monlun and V. Rigalleau

    Citation: Cardiovascular Diabetology 2018 17:82

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  31. Content type: Original investigation

    Patients with type 2 diabetes (T2D) face a high amputation rate. We investigated the relationship between the level of amputation and the presence of micro or macro-vascular disease and related circulating bio...

    Authors: Fabrice Schneider, Pierre-Jean Saulnier, Elise Gand, Mathieu Desvergnes, Nicolas Lefort, Eric Thorin, Nathalie Thorin-Trescases, Kamel Mohammedi, Stéphanie Ragot, Jean-Baptiste Ricco and Samy Hadjadj

    Citation: Cardiovascular Diabetology 2018 17:81

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  32. Content type: Original investigation

    Most studies linking long-term consequences of adolescent underweight and obesity are limited to men.

    Authors: Ariel Furer, Arnon Afek, Omri Orr, Liron Gershovitz, Moran Landau Rabbi, Estela Derazne, Orit Pinhas-Hamiel, Noam Fink, Adi Leiba, Amir Tirosh, Jeremy D. Kark and Gilad Twig

    Citation: Cardiovascular Diabetology 2018 17:80

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  33. Content type: Review

    Cardiovascular (CV) safety of one anti-diabetic medication over another remains partially delineated. We sought to assess the comparative effect on CV outcomes among novel anti-diabetic agents.

    Authors: Xiao-dong Zhuang, Xin He, Da-ya Yang, Yue Guo, Jian-gui He, Hai-peng Xiao and Xin-xue Liao

    Citation: Cardiovascular Diabetology 2018 17:79

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  34. Content type: Original investigation

    High-density lipoproteins (HDLs) can exert anti-atherogenic effects. On top of removing excess cholesterol through reverse cholesterol transport, HDLs play beneficial actions on endothelial function and integr...

    Authors: Daniela Lucchesi, Simona Georgiana Popa, Veronica Sancho, Laura Giusti, Monia Garofolo, Giuseppe Daniele, Laura Pucci, Roberto Miccoli, Giuseppe Penno and Stefano Del Prato

    Citation: Cardiovascular Diabetology 2018 17:78

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  35. Content type: Original investigation

    Cardiovascular risk stratification is complex in type 1 diabetes. We hypothesised that traditional and diabetes-specific cardiovascular risk factors were prevalent and strongly associated with cardiovascular d...

    Authors: Anthony Pease, Arul Earnest, Sanjeeva Ranasinha, Natalie Nanayakkara, Danny Liew, Natalie Wischer, Sofianos Andrikopoulos and Sophia Zoungas

    Citation: Cardiovascular Diabetology 2018 17:77

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  36. Content type: Original investigation

    We investigated whether and to what extent stenosis of predominant collateral donor artery (PCDA) affects coronary collateral flow in relation to blood pressure (BP) in type 2 diabetic patients with chronic to...

    Authors: Ying Shen, Zhen Kun Yang, Jian Hu, Xiao Qun Wang, Yang Dai, Su Zhang, Rui Yan Zhang, Lin Lu, Feng Hua Ding and Wei Feng Shen

    Citation: Cardiovascular Diabetology 2018 17:76

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  37. Content type: Original Investigation

    Inflammation has been recognized as a key feature of both type 2 diabetes mellitus (T2DM) and atherosclerosis. However, the relationships between circulating levels of novel adipose tissue-derived inflammatory...

    Authors: Wei Yang, Yun Li, Jie-Yu Wang, Rui Han and Li Wang

    Citation: Cardiovascular Diabetology 2018 17:75

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  38. Content type: Commentary

    Prevention and treatment strategies for heart failure (HF) in diabetes have not been fully established, at least partly due to lack of recognition of a pathological link between the two and effective antidiabe...

    Authors: Atsushi Tanaka and Koichi Node

    Citation: Cardiovascular Diabetology 2018 17:74

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  39. Content type: Original investigation

    Type 2 diabetes mellitus (T2DM) greatly increases the risks of cardiovascular disease and heart failure. In particular, left ventricular diastolic dysfunction that develops from the early stages of T2DM is an ...

    Authors: Daisuke Matsutani, Masaya Sakamoto, Yosuke Kayama, Norihiko Takeda, Ryuzo Horiuchi and Kazunori Utsunomiya

    Citation: Cardiovascular Diabetology 2018 17:73

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  40. Content type: Original investigation

    Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) are approved drugs for the treatment of hyperglycemia in patients with type 2 diabetes. These effects are mainly mediated by inhibiting endogenous glucagon-...

    Authors: Fausto Chiazza, Harald Tammen, Hiranya Pintana, Grazyna Lietzau, Massimo Collino, Thomas Nyström, Thomas Klein, Vladimer Darsalia and Cesare Patrone

    Citation: Cardiovascular Diabetology 2018 17:60

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  41. Content type: Original investigation

    Type 2 diabetes mellitus (T2DM) is an independent risk factor of cardiovascular disease (CVD), however, the underlying mechanisms are largely unknown. Using non-atherosclerotic internal thoracic arteries (ITAs...

    Authors: Lasse Bach Steffensen, Søren Feddersen, Simone Rørdam Preil and Lars Melholt Rasmussen

    Citation: Cardiovascular Diabetology 2018 17:72

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  42. Content type: Original investigation

    Early glucose lowering intervention in subjects with type 2 diabetes mellitus was demonstrated to be beneficial in terms of micro- and macrovascular risk reduction. However, most of currently ongoing cardiovas...

    Authors: Norbert J. Tripolt, Felix Aberer, Regina Riedl, Jasmin Url, Gudrun Dimsity, Andreas Meinitzer, Tatjana Stojakovic, Faisal Aziz, Ronald Hödl, Gabriele Brachtl, Dirk Strunk, Marianne Brodmann, Franz Hafner and Harald Sourij

    Citation: Cardiovascular Diabetology 2018 17:71

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  43. Content type: Original investigation

    To estimate the risk of developing long-term major cardiovascular and renal complications in relation to levels of body mass index (BMI) in a population of White European (WE), African-Caribbean (AC), and Sout...

    Authors: Ebenezer S. Owusu Adjah, Srikanth Bellary, Wasim Hanif, Kiran Patel, Kamlesh Khunti and Sanjoy K. Paul

    Citation: Cardiovascular Diabetology 2018 17:70

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  44. Content type: Original investigation

    Elevated retinol-binding protein 4 (RBP4) levels may contribute to the development of metabolic abnormalities, but prospective studies evaluating the association between childhood RBP4 levels and metabolic syn...

    Authors: Ge Li, Issy C. Esangbedo, Lu Xu, Junling Fu, Lujiao Li, Dan Feng, Lanwen Han, Xinhua Xiao, Mingyao Li, Jie Mi, Ming Li, Shan Gao and Steven M. Willi

    Citation: Cardiovascular Diabetology 2018 17:69

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  45. Content type: Original investigation

    Epidemiological studies show that maternal diabetes predisposes offspring to cardiovascular and metabolic disorders. However, the precise mechanisms for the underlying penetrance and disease predisposition rem...

    Authors: Radka Cerychova, Romana Bohuslavova, Frantisek Papousek, David Sedmera, Pavel Abaffy, Vladimir Benes, Frantisek Kolar and Gabriela Pavlinkova

    Citation: Cardiovascular Diabetology 2018 17:68

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  46. Content type: Original investigation

    Coronary artery calcified plaque (CAC) is strongly predictive of cardiovascular disease (CVD) events and mortality, both in general populations and individuals with type 2 diabetes at high risk for CVD. CAC is...

    Authors: Laura M. Raffield, Amanda J. Cox, Michael H. Criqui, Fang-Chi Hsu, James G. Terry, Jianzhao Xu, Barry I. Freedman, J. Jeffrey Carr and Donald W. Bowden

    Citation: Cardiovascular Diabetology 2018 17:67

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  47. Content type: Original investigation

    Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2 diabetes. The aim of the study was to assess the associat...

    Authors: Marc Carbonell, Esmeralda Castelblanco, Xavier Valldeperas, Àngels Betriu, Alícia Traveset, Minerva Granado-Casas, Marta Hernández, Federico Vázquez, Mariona Martín, Esther Rubinat, Albert Lecube, Josep Franch-Nadal, Elvira Fernández, Manel Puig-Domingo, Angelo Avogaro, Núria Alonso…

    Citation: Cardiovascular Diabetology 2018 17:66

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  48. Content type: Original investigation

    Type 2 diabetes is associated with endothelial dysfunction leading to cardiovascular disease. CD34+ endothelial Progenitor Cells (EPCs) are responsible for endothelial repair and neo-angiogenesis and can be us...

    Authors: Fiona J. Dore, Cleyton C. Domingues, Neeki Ahmadi, Nabanita Kundu, Yana Kropotova, Sara Houston, Carol Rouphael, Aytan Mammadova, Linda Witkin, Anamil Khiyami, Richard L. Amdur and Sabyasachi Sen

    Citation: Cardiovascular Diabetology 2018 17:65

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