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  1. The endothelium plays a pivotal role in maintaining vascular health. Obesity is a global epidemic that has seen dramatic increases in both adult and pediatric populations. Obesity perturbs the integrity of nor...

    Authors: Karima Ait-Aissa, Quynh My Nguyen, Mohanad Gabani, Adam Kassan, Santosh Kumar, Soo-Kyoung Choi, Alexis A. Gonzalez, Tahsin Khataei, Amal M. Sahyoun, Cheng Chen and Modar Kassan

    Citation: Cardiovascular Diabetology 2020 19:136

    Content type: Review

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  2. Macrophage accumulation in arteriosclerotic plaque of coronary arteries is involved in plaque destabilization. Atherosclerosis has been known to be progressive in patients with type 2 diabetes mellitus (DM). T...

    Authors: Takaaki Kogo, Takafumi Hiro, Daisuke Kitano, Tadateru Takayama, Daisuke Fukamachi, Tomoyuki Morikawa, Mitsumasa Sudo and Yasuo Okumura

    Citation: Cardiovascular Diabetology 2020 19:135

    Content type: Original investigation

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  3. The association between type 2 diabetes mellitus (T2DM) and heart failure (HF) is well established. Early in the course of the diabetic disease, some degree of impaired exercise capacity (a powerful marker of ...

    Authors: Lorenzo Nesti, Nicola Riccardo Pugliese, Paolo Sciuto and Andrea Natali

    Citation: Cardiovascular Diabetology 2020 19:134

    Content type: Commentary

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  4. Patients with type 2 diabetes are under substantially higher risk of in-stent restenosis (ISR) after coronary stent implantation. We sought to investigate whether visit-to-visit HbA1c variability is a potential p...

    Authors: Chen Die Yang, Ying Shen, Lin Lu, Zhen Kun Yang, Jian Hu, Rui Yan Zhang, Wei Feng Shen, Feng Hua Ding and Xiao Qun Wang

    Citation: Cardiovascular Diabetology 2020 19:133

    Content type: Original investigation

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  5. Patients with type 2 diabetes mellitus (T2DM) are predisposed to poor cardiovascular outcomes after ST-segment elevation myocardial infarction (STEMI). Left ventricular adverse remodeling (LVAR) triggered upon...

    Authors: Chen Die Yang, Ying Shen, Feng Hua Ding, Zhen Kun Yang, Jian Hu, Wei Feng Shen, Rui Yan Zhang, Lin Lu and Xiao Qun Wang

    Citation: Cardiovascular Diabetology 2020 19:131

    Content type: Original investigation

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  6. Type 2 diabetes is closely related to an increased risk of atrial fibrillation (AF) and atrial flutter (AFL). Whether sodium-glucose cotransporter 2 (SGLT2) inhibitors can attenuate AF/AFL progression remains ...

    Authors: Wen-jie Li, Xing-qing Chen, Ling-ling Xu, Yuan-qing Li and Bi-hui Luo

    Citation: Cardiovascular Diabetology 2020 19:130

    Content type: Review

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  7. Pericardial fat (PF) has been suggested to directly act on cardiomyocytes, leading to diastolic dysfunction. The aim of this study was to investigate whether a higher PF volume is associated with a lower diast...

    Authors: Vera H. W. de Wit-Verheggen, Sibel Altintas, Romy J. M. Spee, Casper Mihl, Sander M. J. van Kuijk, Joachim E. Wildberger, Vera B. Schrauwen-Hinderling, Bas L. J. H. Kietselaer and Tineke van de Weijer

    Citation: Cardiovascular Diabetology 2020 19:129

    Content type: Original investigation

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  8. Bempedoic acid is an oral, once-daily, first-in-class drug being developed for the treatment of hyperlipidemia. However, evidence of bempedoic acid use for the prevention of cardiovascular events and diabetes ...

    Authors: Xing Wang, Yu Zhang, Huiwen Tan, Peng Wang, Xi Zha, Weelic Chong, Liangxue Zhou and Fang Fang

    Citation: Cardiovascular Diabetology 2020 19:128

    Content type: Original investigation

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  9. The role of omega-3 polyunsaturated fatty acids (n-3PUFA), and the potential impact of n-3PUFA supplementation, in the treatment and management of type 1 diabetes (T1D) remains unclear and controversial. There...

    Authors: Lauren L. O’Mahoney, Gareth Dunseath, Rachel Churm, Mel Holmes, Christine Boesch, Antonios Stavropoulos-Kalinoglou, Ramzi A. Ajjan, Karen M. Birch, Nicolas M. Orsi, Georgia Mappa, Oliver J. Price and Matthew D. Campbell

    Citation: Cardiovascular Diabetology 2020 19:127

    Content type: Original investigation

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  10. Lipoprotein disturbances have been associated with increased cardiovascular disease (CVD) risk in type 1 diabetes mellitus (T1DM). We assessed the advanced lipoprotein profile in T1DM individuals, and analysed...

    Authors: Antonio J. Amor, Esmeralda Castelblanco, Marta Hernández, Marga Gimenez, Minerva Granado-Casas, Jesús Blanco, Berta Soldevila, Enric Esmatjes, Ignacio Conget, Nuria Alonso, Emilio Ortega and Didac Mauricio

    Citation: Cardiovascular Diabetology 2020 19:126

    Content type: Original investigation

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  11. Adiponectin plays role in multiple metabolic pathways. Previous studies in cardiovascular disease evaluated the association between adiponectin and clinical outcomes, yielding conflicting results. The aim of t...

    Authors: Wen-Jun Tu, Han-Cheng Qiu, Ya-Kun Liu, Qiang Liu, Xianwei Zeng and Jizong Zhao

    Citation: Cardiovascular Diabetology 2020 19:125

    Content type: Original investigation

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  12. Observational series suggest a mortality benefit from metformin in the heart failure (HF) population. However, the benefit of metformin in HF with preserved ejection fraction (HFpEF) has yet to be explored. We...

    Authors: Amera Halabi, Jonathan Sen, Quan Huynh and Thomas H. Marwick

    Citation: Cardiovascular Diabetology 2020 19:124

    Content type: Original investigation

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  13. Ferritin, a crucial element for iron homeostasis, is associated with chronic diseases characterized by subclinical inflammation such as essential arterial hypertension and type 2 diabetes mellitus (T2DM), show...

    Authors: Angela Sciacqua, Ettore Ventura, Giovanni Tripepi, Velia Cassano, Graziella D’Arrigo, Stefanos Roumeliotis, Raffale Maio, Sofia Miceli, Maria Perticone, Francesco Andreozzi, Giorgio Sesti and Francesco Perticone

    Citation: Cardiovascular Diabetology 2020 19:123

    Content type: Original investigation

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  14. Studies suggest that cardio-vascular risk factors could foster the development of type 2 diabetes (T2D). This could partly be mediated by pancreatic atherosclerosis resulting in pancreatic ischemia. We hypothe...

    Authors: Laure Alexandre-Heymann, Matthias Barral, Anthony Dohan and Etienne Larger

    Citation: Cardiovascular Diabetology 2020 19:122

    Content type: Original investigation

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  15. Angiopoietin-like protein 8 (ANGPTL8), an important regulator of lipid metabolism, is increased in diabetes and is associated with insulin resistance. However, the role of ANGPTL8 in the outcomes of diabetic p...

    Authors: Huajie Zou, Yongping Xu, Xi Chen, Ping Yin, Danpei Li, Wenjun Li, Junhui Xie, Shiying Shao, Liegang Liu and Xuefeng Yu

    Citation: Cardiovascular Diabetology 2020 19:121

    Content type: Original investigation

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  16. Growth differentiation factor-15 (GDF-15) is a marker of inflammation, oxidative stress and it is associated with adverse prognosis in cardiovascular disease. The aim of the present cohort study is to investig...

    Authors: Man Li, Lei Duan, Yu-Lun Cai, Hui-Ying Li, Ben-Chuan Hao, Jian-Qiao Chen and Hong-Bin Liu

    Citation: Cardiovascular Diabetology 2020 19:120

    Content type: Original investigation

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  17. Diabetes mellitus is one of the risk factors for coronary artery disease and frequently associated with multivessels disease and poor clinical outcomes. Long term outcome of successful revascularization of chr...

    Authors: Chuan-Tsai Tsai, Wei-Chieh Huang, Hsin-I Teng, Yi-Lin Tsai and Tse-Min Lu

    Citation: Cardiovascular Diabetology 2020 19:119

    Content type: Original investigation

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  18. Obesity, especially abdominal obesity, has been considered a risk factor for diabetic complications. Many abdominal obesity indices have been established, including neck circumference (NC), waist-to-hip ratio ...

    Authors: Heng Wan, Yuying Wang, Qian Xiang, Sijie Fang, Yi Chen, Chi Chen, Wen Zhang, Haojie Zhang, Fangzhen Xia, Ningjian Wang and Yingli Lu

    Citation: Cardiovascular Diabetology 2020 19:118

    Content type: Original investigation

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  19. Previous publications about the association between fatty-acid binding protein 4 (FABP4) and cardiac remodeling have reported different, both beneficial and harmful, associations. Aim of the present investigat...

    Authors: Beatrice von Jeinsen, Lisa Ritzen, Julia Vietheer, Claudia Unbehaun, Maren Weferling, Christoph Liebetrau, Christian W. Hamm, Andreas Rolf and Till Keller

    Citation: Cardiovascular Diabetology 2020 19:117

    Content type: Original investigation

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  20. Previous studies have investigated the relationship of the triglyceride glucose (TyG) index with the incidence of cardiovascular events. However, to date, there have been no studies comparing the predictive va...

    Authors: Chengping Hu, Jianwei Zhang, Jinxing Liu, Yan Liu, Ang Gao, Yong Zhu and Yingxin Zhao

    Citation: Cardiovascular Diabetology 2020 19:116

    Content type: Original investigation

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  21. The coronavirus disease 2019 (COVID-19) has been declared as pandemic by the World Health Organization and is causing substantial morbidity and mortality all over the world. Type 2 diabetes, hypertension, and ...

    Authors: Miriam Longo, Paola Caruso, Maria Ida Maiorino, Giuseppe Bellastella, Dario Giugliano and Katherine Esposito

    Citation: Cardiovascular Diabetology 2020 19:115

    Content type: Commentary

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  22. In the pandemic “Corona Virus Disease 2019” (COVID-19) people with diabetes have a high risk to require ICU admission. The management of diabetes in Intensive Care Unit is always challenging, however, when dia...

    Authors: Antonio Ceriello, Eberhard Standl, Doina Catrinoiu, Baruch Itzhak, Nebojsa M. Lalic, Dario Rahelic, Oliver Schnell, Jan Škrha and Paul Valensi

    Citation: Cardiovascular Diabetology 2020 19:114

    Content type: Review

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  23. The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using s...

    Authors: Ki-Bum Won, Byoung Kwon Lee, Hyung-Bok Park, Ran Heo, Sang-Eun Lee, Asim Rizvi, Fay Y. Lin, Amit Kumar, Martin Hadamitzky, Yong-Jin Kim, Ji Min Sung, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J. Budoff, Ilan Gottlieb…

    Citation: Cardiovascular Diabetology 2020 19:113

    Content type: Original investigation

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  24. Both lipid and glucose abnormalities are associated with hypertension (HTN). However, it is unclear whether the triglyceride-glucose (TyG) index is associated with HTN. Therefore the aim of this study is to in...

    Authors: Binruo Zhu, Jie Wang, Kang Chen, Wenhua Yan, Anping Wang, Weiqing Wang, Zhengnan Gao, Xulei Tang, Li Yan, Qin Wan, Zuojie Luo, Guijun Qin, Lulu Chen and Yiming Mu

    Citation: Cardiovascular Diabetology 2020 19:112

    Content type: Original investigation

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  25. Merging studies have reported the association of lipoprotein(a) [Lp(a)] with poor outcomes of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). However, the prognostic importance ...

    Authors: Yan Zhang, Jing-Lu Jin, Ye-Xuan Cao, Hui-Wen Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Ying Gao, Qi Hua, Yan-Fang Li, Rui-Xia Xu and Jian-Jun Li

    Citation: Cardiovascular Diabetology 2020 19:111

    Content type: Original investigation

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  26. This study aimed to investigate the preventive effects of tofogliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, on atherosclerosis progression in type 2 diabetes (T2DM) patients without ...

    Authors: Naoto Katakami, Tomoya Mita, Hidenori Yoshii, Toshihiko Shiraiwa, Tetsuyuki Yasuda, Yosuke Okada, Keiichi Torimoto, Yutaka Umayahara, Hideaki Kaneto, Takeshi Osonoi, Tsunehiko Yamamoto, Nobuichi Kuribayashi, Kazuhisa Maeda, Hiroki Yokoyama, Keisuke Kosugi, Kentaro Ohtoshi…

    Citation: Cardiovascular Diabetology 2020 19:110

    Content type: Original investigation

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  27. Plaque rupture (PR) and plaque erosion (PE) are main causes of acute myocardial infarction with different demographic and histology characteristics and need different treatment strategy. PR and PE can be ident...

    Authors: Jinxin Liu, Shanjie Wang, Can Cui, Hengxuan Cai, Rong Sun, Weili Pan, Shaohong Fang and Bo Yu

    Citation: Cardiovascular Diabetology 2020 19:109

    Content type: Original investigation

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  28. The relationship between triglyceride-glucose index (TyG index) and the prevalence and prognosis of cardiovascular disease has been confirmed by former studies. However, it remains uncertain whether TyG index ...

    Authors: Qi Zhao, Ting-Yu Zhang, Yu-Jing Cheng, Yue Ma, Ying-Kai Xu, Jia-Qi Yang and Yu-Jie Zhou

    Citation: Cardiovascular Diabetology 2020 19:108

    Content type: Original investigation

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  29. In randomised clinical trials, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium–glucose cotransporter 2 (SGLT-2) inhibitors reduced cardiovascular events in patients with type 2 diabetes (T2D) ...

    Authors: David Thein, Mia Nielsen Christiansen, Ulrik Madvig Mogensen, Johan Skov Bundgaard, Rasmus Rørth, Christian Madelaire, Emil Loldrup Fosbøl, Morten Schou, Christian Torp-Pedersen, Gunnar Gislason, Lars Køber and Søren Lund Kristensen

    Citation: Cardiovascular Diabetology 2020 19:107

    Content type: Original investigation

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  30. To assess the associations of various HbA1c measures, including a single baseline HbA1c value, overall mean, yearly updated means, standard deviation (HbA1c-SD), coefficient of variation (HbA1c-CV), and HbA1c ...

    Authors: Chen-Yi Yang, Pei-Fang Su, Jo-Ying Hung, Huang-Tz Ou and Shihchen Kuo

    Citation: Cardiovascular Diabetology 2020 19:105

    Content type: Original investigation

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  31. The atherogenicity of remnant cholesterol (RC) has been underlined by recent guidelines, which was linked to coronary artery disease (CAD), especially for patients with diabetes mellitus (DM). This study aimed...

    Authors: Ye-Xuan Cao, Hui-Wen Zhang, Jing-Lu Jin, Hui-Hui Liu, Yan Zhang, Ying Gao, Yuan-Lin Guo, Na-Qiong Wu, Qi Hua, Yan-Fang Li, Xiao-Lin Li, Rui-Xia Xu, Chuan-Jue Cui, Geng Liu, Qian Dong, Jing Sun…

    Citation: Cardiovascular Diabetology 2020 19:104

    Content type: Original investigation

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  32. Both diabetes and obesity are risk factors for perioperative major adverse events. This study aims to evaluate the association between prior bariatric surgery (prior-BS) and perioperative cardiovascular outcom...

    Authors: Jiewen Jin, Zhantao Deng, Lijuan Xu, Hai Li, Pengyuan Zhang, Liehua Liu, Juan Liu, Hedong Han, Zhimin Huang, Xiaopei Cao, Haipeng Xiao and Yanbing Li

    Citation: Cardiovascular Diabetology 2020 19:103

    Content type: Original investigation

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  33. Left ventricular systolic dysfunction (LVSD) occurs frequently after acute ST-segment elevation myocardial infarction (STEMI). The predisposing factors and underlying mechanism of post-infarct LVSD are not ful...

    Authors: Yong Zhu, Kesen Liu, Shuai Meng, Ruofei Jia, Xuan Lei, Maolin Chen, Kaiyuan Zou, Huagang Zhu and Zening Jin

    Citation: Cardiovascular Diabetology 2020 19:101

    Content type: Original investigation

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  34. In this study, we compared the outcomes of medical therapy (MT) with successful percutaneous coronary intervention (PCI) in chronic total occlusions (CTO) patients with and without type 2 diabetes mellitus.

    Authors: Lei Guo, Junjie Wang, Huaiyu Ding, Shaoke Meng, Xiaoyan Zhang, Haichen Lv, Lei Zhong, Jian Wu, Jiaying Xu, Xuchen Zhou and Rongchong Huang

    Citation: Cardiovascular Diabetology 2020 19:100

    Content type: Original investigation

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  35. Physical inactivity (PI) is associated with the development of non-communicable chronic diseases. The purposes of this study were to estimate the extent to which the 31% relative increase in PI among 35–64 yea...

    Authors: Catalina Medina, Pamela Coxson, Joanne Penko, Ian Janssen, Sergio Bautista-Arredondo, Simón Barquera and Kirsten Bibbins-Domingo

    Citation: Cardiovascular Diabetology 2020 19:99

    Content type: Original investigation

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  36. Sodium/glucose cotransporter-2 inhibitors (SGLT2i) are a new type of glucose-lowering drug that can reduce blood glucose by inhibiting its reabsorption in proximal tubules and by promoting urinary glucose excr...

    Authors: Lihua Ni, Cheng Yuan, Guopeng Chen, Changjiang Zhang and Xiaoyan Wu

    Citation: Cardiovascular Diabetology 2020 19:98

    Content type: Review

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  37. The influence of intensive glucose control in diabetic patients on the macrovascular outcomes is controversial. Thus, this study aimed to elucidate the effect of preprocedural hemoglobin A1c (HbA1c) on clinica...

    Authors: Jung-Joon Cha, Hyoeun Kim, Young-Guk Ko, Donghoon Choi, Jae-Hwan Lee, Chang-Hwan Yoon, In-Ho Chae, Cheol Woong Yu, Seung Whan Lee, Sang-Rok Lee, Seung Hyuk Choi, Yoon Seok Koh and Pil-Ki Min

    Citation: Cardiovascular Diabetology 2020 19:97

    Content type: Original investigation

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  38. The cardiovascular outcome trials (CVOTs) have shown that glucagon like peptide-1 receptor agonists (GLP1RAs) have varying degrees of cardiovascular (CV) safety in patients with type 2 diabetes mellitus (T2DM....

    Authors: Osamah M. Alfayez, Omar A. Almohammed, Omar S. Alkhezi, Abdulaali R. Almutairi and Majed S. Al Yami

    Citation: Cardiovascular Diabetology 2020 19:96

    Content type: Original investigation

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  39. Dapagliflozin is one of the novel glucose-lowering agents, which has recently been reported to reduce the risk of hospitalization for heart failure (hHF). The present study aimed to compare the differences bet...

    Authors: Jong-Mi Seong, Jong Joo Kim, Hae Jin Kim and Hyun Soon Sohn

    Citation: Cardiovascular Diabetology 2020 19:95

    Content type: Original investigation

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  40. Studies assessing the efficacy of pioglitazone solely for primary stroke prevention in Asian patients with type 2 diabetes mellitus (DM) and present multiple cardiovascular (CV) risk factors are rare. Thus, we...

    Authors: Yi-Chih Hung, Lu-Ting Chiu, Hung-Yu Huang and Da-Tian Bau

    Citation: Cardiovascular Diabetology 2020 19:94

    Content type: Original investigation

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  41. The potential for PPAR agonists to positively affect risk of cardiovascular disease in patients with type 2 diabetes (T2DM) is of persistent attention. The PRESS XII study primarily aimed to evaluate the effic...

    Authors: Manjunath Krishnappa, Kishor Patil, Krupi Parmar, Purav Trivedi, Nirali Mody, Chintan Shah, Khushboo Faldu, Sanjay Maroo and Deven Parmar

    Citation: Cardiovascular Diabetology 2020 19:93

    Content type: Original investigation

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  42. Accumulation of advanced glycation end products (AGEs) leads to chronic glycation of proteins and tissue damage, particularly in patients with diabetes mellitus (DM). We aimed to evaluate whether increased acc...

    Authors: Magdalena Kopytek, Michał Ząbczyk, Piotr Mazur, Anetta Undas and Joanna Natorska

    Citation: Cardiovascular Diabetology 2020 19:92

    Content type: Original investigation

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  43. A sodium-glucose co-transporter 2 (SGLT-2) inhibitor had favorable impact on the attenuation of hyperglycemia together with the severity of heart failure. However, the effects of acute dapagliflozin administra...

    Authors: Sarayut Lahnwong, Siripong Palee, Nattayaporn Apaijai, Sirawit Sriwichaiin, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Siriporn C. Chattipakorn and Nipon Chattipakorn

    Citation: Cardiovascular Diabetology 2020 19:91

    Content type: Original investigation

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  44. Exercise induced albuminuria (EiA) is elevated in patients with metabolic dysfunction and diabetes, and may serve as an early biomarker for endothelial dysfunction and “kidney reserve”. However, the change in ...

    Authors: Rafael Y. Brzezinski, Limor Friedensohn, Itzhak Shapira, David Zeltser, Ori Rogowski, Shlomo Berliner, Ayelet Grupper and Shani Shenhar-Tsarfaty

    Citation: Cardiovascular Diabetology 2020 19:90

    Content type: Original investigation

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  45. Fatty acid-binding protein 4 (FABP4) acts as a novel adipokine, and elevated FABP4 concentration is associated with obesity, insulin resistance and atherosclerosis. Dipeptidyl peptidase-4 (DPP-4) inhibitors, a...

    Authors: Masato Furuhashi, Ichiro Sakuma, Takeshi Morimoto, Yukimura Higashiura, Akiko Sakai, Megumi Matsumoto, Mio Sakuma, Michio Shimabukuro, Takashi Nomiyama, Osamu Arasaki, Koichi Node and Shinichiro Ueda

    Citation: Cardiovascular Diabetology 2020 19:89

    Content type: Original investigation

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  46. The role of right ventricular (RV) and atrial (RA) structure and function, in the increased heart failure risk in (pre)diabetes is incompletely understood. The purpose of this study is to investigate the assoc...

    Authors: Pauline B. C. Linssen, Marja G. J. Veugen, Ronald M. A. Henry, Carla J. H. van der Kallen, Abraham A. Kroon, Miranda T. Schram, Hans-Peter Brunner-La Rocca and Coen D. A. Stehouwer

    Citation: Cardiovascular Diabetology 2020 19:88

    Content type: Original investigation

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  47. Type 2 diabetes mellitus (DM) is a risk factor for cardiovascular diseases and is common among patients undergoing coronary artery bypass grafting (CABG) surgery. The main objective of our study was to investi...

    Authors: Eilon Ram, Leonid Sternik, Robert Klempfner, Zaza Iakobishvili, Enrique Z. Fisman, Alexander Tenenbaum, Elchanan Zuroff, Yael Peled and Ehud Raanani

    Citation: Cardiovascular Diabetology 2020 19:86

    Content type: Original investigation

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