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  1. Original investigation

    Inverse associations between serum levels of secreted frizzled-related protein-5 (SFRP5) and multiple cardiometabolic risk factors: KORA F4 study

    Secreted frizzled-related protein (Sfrp)5 has beneficial effects on insulin sensitivity, inflammation and cardiovascular risk in different mouse models, but its relevance for cardiometabolic diseases in humans...

    Maren Carstensen-Kirberg, Julia M. Kannenberg, Cornelia Huth, Christa Meisinger, Wolfgang Koenig, Margit Heier, Annette Peters, Wolfgang Rathmann, Michael Roden, Christian Herder and Barbara Thorand

    Cardiovascular Diabetology 2017 16:109

    Published on: 29 August 2017

  2. Original investigation

    Relationship between the triglyceride glucose index and coronary artery calcification in Korean adults

    The triglyceride glucose (TyG) index has been considered a simple surrogate marker of insulin resistance. However, few studies have investigated the relationship between the TyG index and coronary artery calci...

    Min Kyung Kim, Chul Woo Ahn, Shinae Kang, Ji Sun Nam, Kyung Rae Kim and Jong Suk Park

    Cardiovascular Diabetology 2017 16:108

    Published on: 23 August 2017

  3. Original investigation

    Effects of background statin therapy on glycemic response and cardiovascular events following initiation of insulin therapy in type 2 diabetes: a large UK cohort study

    Statins may increase the risk of new-onset diabetes and adversely affect glycaemic control, but their effects on the glycemic response and mortality outcomes following commencement of insulin therapy in patien...

    Uchenna Anyanwagu, Jil Mamza, Richard Donnelly and Iskandar Idris

    Cardiovascular Diabetology 2017 16:107

    Published on: 22 August 2017

  4. Original investigation

    Contribution of serum FGF21 level to the identification of left ventricular systolic dysfunction and cardiac death

    The relationship between fibroblast growth factor 21 (FGF21) and cardiovascular disease has been well established in recent studies. This study aimed to investigate the relationship between FGF21 and left vent...

    Yun Shen, Xueli Zhang, Xiaoping Pan, Yiting Xu, Qin Xiong, Zhigang Lu, Xiaojing Ma, Yuqian Bao and Weiping Jia

    Cardiovascular Diabetology 2017 16:106

    Published on: 18 August 2017

  5. Original investigation

    Changes in proteinuria and the risk of myocardial infarction in people with diabetes or pre-diabetes: a prospective cohort study

    The relationship between changes in proteinuria and myocardial infarction (MI) remains unclear in people with diabetes or pre-diabetes. We aimed to evaluate the predictive value and independent role of changes...

    Anxin Wang, Yang Sun, Xiaoxue Liu, Zhaoping Su, Junjuan Li, Yanxia Luo, Shuohua Chen, Jianli Wang, Xia Li, Zhan Zhao, Huiping Zhu, Shouling Wu and Xiuhua Guo

    Cardiovascular Diabetology 2017 16:104

    Published on: 15 August 2017

    The Erratum to this article has been published in Cardiovascular Diabetology 2017 16:117

  6. Original investigation

    New onset diabetes in adulthood is associated with a substantial risk for mortality at all ages: a population based historical cohort study with a decade-long follow-up

    Diabetes has been reported to be associated with an increased relative risk for mortality, with estimates ranging from 1.1 to 2.1. Findings are inconsistent regarding modification of the risk by gender and by ...

    Inbar Zucker, Tamy Shohat, Rachel Dankner and Gabriel Chodick

    Cardiovascular Diabetology 2017 16:105

    Published on: 15 August 2017

  7. Original investigation

    Combined effect of metformin with ascorbic acid versus acetyl salicylic acid on diabetes-related cardiovascular complication; a 12-month single blind multicenter randomized control trial

    We aimed to investigate the efficacy of ascorbic acid and acetylsalicylic acid among type II diabetes mellitus patients using metformin (only) for diabetes management therapy.

    Syed Wasif Gillani, Syed Azhar Syed Sulaiman, Mohi Iqbal Mohammad Abdul and Mirza R. Baig

    Cardiovascular Diabetology 2017 16:103

    Published on: 14 August 2017

  8. Original investigation

    Admission blood glucose and 10-year mortality among patients with or without pre-existing diabetes mellitus hospitalized with heart failure

    High admission blood glucose (ABG) level has been associated with a poor short-term outcome among non-diabetic patients with heart failure (HF). We aimed to investigate the association between ABG levels and l...

    Osnat Itzhaki Ben Zadok, Ran Kornowski, Ilan Goldenberg, Robert Klempfner, Yoel Toledano, Yitschak Biton, Enrique Z. Fisman, Alexander Tenenbaum, Gregory Golovchiner, Ehud Kadmon, Alexander Omelchenko, Tuvia Ben Gal and Alon Barsheshet

    Cardiovascular Diabetology 2017 16:102

    Published on: 14 August 2017

  9. Original investigation

    Gender differences in hospital admissions for major cardiovascular events and procedures in people with and without diabetes in England: a nationwide study 2004–2014

    Secondary prevention of cardiovascular disease (CVD) has improved immensely during the past decade but controversies persist on cardiovascular benefits among women with diabetes. We investigated 11-year trends...

    Anthony A. Laverty, Alex Bottle, Sung-Hee Kim, Bhakti Visani, Azeem Majeed, Christopher Millett and Eszter P. Vamos

    Cardiovascular Diabetology 2017 16:100

    Published on: 10 August 2017

  10. Original investigation

    Serum high mobility group box-1 and osteoprotegerin levels are associated with peripheral arterial disease and critical limb ischemia in type 2 diabetic subjects

    High mobility group box-1 (HMGB-1) is a nuclear protein also acting as inflammatory mediator, whilst osteoprotegerin (OPG), member of tumor necrosis factor receptor superfamily, is indicated as marker of vascu...

    Silvia Giovannini, Giovanni Tinelli, Federico Biscetti, Giuseppe Straface, Flavia Angelini, Dario Pitocco, Luciana Mucci, Raffaele Landolfi and Andrea Flex

    Cardiovascular Diabetology 2017 16:99

    Published on: 8 August 2017

  11. Original investigation

    Impact of CD14++CD16+ monocytes on plaque vulnerability in diabetic and non-diabetic patients with asymptomatic coronary artery disease: a cross-sectional study

    Previously, we have reported that daily glucose fluctuations could affect coronary plaque vulnerability, but the underlying mechanisms remained unclear. This study sought to investigate the impact of CD14++CD16+ ...

    Naofumi Yoshida, Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Masaru Kuroda, Daisuke Terashita, Hachidai Takahashi, Kazuhiko Sakaguchi, Yushi Hirota, Takuo Emoto, Hilman Zulkifli Amin, Taiji Mizoguchi, Tomohiro Hayashi, Naoto Sasaki, Tomoya Yamashita, Wataru Ogawa…

    Cardiovascular Diabetology 2017 16:96

    Published on: 8 August 2017

  12. Original investigation

    Neutrophil gelatinase associated lipocalin (NGAL) is elevated in type 2 diabetics with carotid artery stenosis and reduced under metformin treatment

    Neutrophil gelatinase-associated lipocalin (NGAL), an acute phase protein released by neutrophils, has been described as biomarker of inflammatory states. Type 2 diabetes mellitus (T2DM) is characterized by in...

    W. Eilenberg, S. Stojkovic, A. Piechota-Polanczyk, A. Kaider, N. Kozakowski, W. J. Weninger, J. Nanobachvili, J. Wojta, I. Huk, S. Demyanets and C. Neumayer

    Cardiovascular Diabetology 2017 16:98

    Published on: 8 August 2017

  13. Original investigation

    Heart failure hospitalization risk associated with use of two classes of oral antidiabetic medications: an observational, real-world analysis

    Newer oral antidiabetic drug classes are expanding treatment options for type 2 diabetes mellitus (T2DM); however, concerns remain. The objective was to assess relative risk of heart failure hospitalization of...

    Santosh Gautam, Abiy Agiro, John Barron, Thomas Power, Harry Weisman and Jeff White

    Cardiovascular Diabetology 2017 16:93

    Published on: 31 July 2017

  14. Original investigation

    Preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes and classical type 1 diabetes

    LADA is probably the most prevalent form of autoimmune diabetes. Nevertheless, there are few data about cardiovascular disease in this group of patients. The aim of this study was to investigate the frequency ...

    Marta Hernández, Carolina López, Jordi Real, Joan Valls, Emilio Ortega-Martinez de Victoria, Federico Vázquez, Esther Rubinat, Minerva Granado-Casas, Nuria Alonso, Teresa Molí, Angels Betriu, Albert Lecube, Elvira Fernández, Richard David Leslie and Dídac Mauricio

    Cardiovascular Diabetology 2017 16:94

    Published on: 28 July 2017

  15. Original investigation

    Comparative effects of microvascular and macrovascular disease on the risk of major outcomes in patients with type 2 diabetes

    Microvascular disease is associated with a high risk of macrovascular events in patients with type 2 diabetes, but the impact of macrovascular disease on the risk of microvascular events remains unknown. We so...

    Kamel Mohammedi, Mark Woodward, Michel Marre, Stephen Colagiuri, Mark Cooper, Stephen Harrap, Giuseppe Mancia, Neil Poulter, Bryan Williams, Sophia Zoungas and John Chalmers

    Cardiovascular Diabetology 2017 16:95

    Published on: 27 July 2017

  16. Original investigation

    Circulating sortilin level as a potential biomarker for coronary atherosclerosis and diabetes mellitus

    A previous genome-wide association study showed that a genetic variant of sortilin was associated with the risk of coronary artery disease (CAD). However, the role of circulating sortilin is still unknown. We ...

    Tae Jung Oh, Chang Ho Ahn, Bo-Rahm Kim, Kyoung Min Kim, Jae Hoon Moon, Soo Lim, Kyong Soo Park, Cheong Lim, HakChul Jang and Sung Hee Choi

    Cardiovascular Diabetology 2017 16:92

    Published on: 20 July 2017

  17. Original investigation

    Symmetric and asymmetric dimethylarginine as risk markers of cardiovascular disease, all-cause mortality and deterioration in kidney function in persons with type 2 diabetes and microalbuminuria

    To evaluate symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA) as risk markers of cardiovascular disease, all-cause mortality and deterioration in renal function in a well characterised t...

    Emilie H. Zobel, Bernt Johan von Scholten, Henrik Reinhard, Frederik Persson, Tom Teerlink, Tine W. Hansen, Hans-Henrik Parving, Peter K. Jacobsen and Peter Rossing

    Cardiovascular Diabetology 2017 16:88

    Published on: 11 July 2017

  18. Original investigation

    The impact of DPP-4 inhibitors on long-term survival among diabetic patients after first acute myocardial infarction

    Previous studies regarding the cardioprotective effects of dipeptidyl peptidase 4 (DPP-4) inhibitors have not provided sufficient evidence of a relationship between DPP-4 inhibition and actual cardiovascular o...

    Mei-Tzu Wang, Sheng-Che Lin, Pei-Ling Tang, Wang-Ting Hung, Chin-Chang Cheng, Jin-Shiou Yang, Hong-Tai Chang, Chun-Peng Liu, Guang-Yuan Mar and Wei-Chun Huang

    Cardiovascular Diabetology 2017 16:89

    Published on: 11 July 2017

  19. Original investigation

    Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia

    Omentin-1, also known as Intelectin-1 (ITLN1), is an adipokine with plasma levels associated with diabetes, obesity, and coronary artery disease. Recent studies suggest that ITLN1 can mitigate myocardial ische...

    Louis A. Saddic, Sarah M. Nicoloro, Olga T. Gupta, Michael P. Czech, Joshua Gorham, Stanton K. Shernan, Christine E. Seidman, Jon G. Seidman, Sary F. Aranki, Simon C. Body, Timothy P. Fitzgibbons and Jochen D. Muehlschlegel

    Cardiovascular Diabetology 2017 16:87

    Published on: 7 July 2017

  20. Original investigation

    Reduced HDL function in children and young adults with type 1 diabetes

    Patients with type 1 diabetes (T1D) are at increased risk of cardiovascular disease (CVD). Measures of high-density lipoprotein (HDL) function provide a better risk estimate for future CVD events than serum le...

    Martin Heier, Mark S. Borja, Cathrine Brunborg, Ingebjørg Seljeflot, Hanna Dis Margeirsdottir, Kristian F. Hanssen, Knut Dahl-Jørgensen and Michael N. Oda

    Cardiovascular Diabetology 2017 16:85

    Published on: 6 July 2017

  21. Original investigation

    Red blood cell distribution width as a prognostic marker in patients with heart failure and diabetes mellitus

    Red blood cell distribution width (RDW) is an established prognostic marker in acute and chronic heart failure (HF). Recent studies have pointed out a link among RDW, diabetes mellitus (DM) and inflammation. W...

    Andrew Xanthopoulos, Gregory Giamouzis, Andreas Melidonis, Takeshi Kitai, Efi Paraskevopoulou, Pinelopi Paraskevopoulou, Sotirios Patsilinakos, Filippos Triposkiadis and John Skoularigis

    Cardiovascular Diabetology 2017 16:81

    Published on: 6 July 2017

  22. Original investigation

    Westernization of lifestyle affects quantitative and qualitative changes in adiponectin

    Although Japanese–Americans and native Japanese share the same genetic predispositions, they live different lifestyles, resulting in insulin resistance in Japanese–Americans. We investigated whether the quanti...

    Mitsunobu Kubota, Masayasu Yoneda, Norikazu Maeda, Haruya Ohno, Kenji Oki, Tohru Funahashi, Iichiro Shimomura and Noboru Hattori

    Cardiovascular Diabetology 2017 16:83

    Published on: 6 July 2017

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