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  1. The aim of this study was to examine the effects of intense physical training on vascular function in streptozotocin-diabetic rats. We focused on the endothelium-dependent relaxation (EDR) induced by acetylcho...

    Authors: Mohamed Sami Zguira, Sophie Vincent, Solène Le Douairon Lahaye, Ludivine Malarde, Zouhair Tabka and Bernard Saïag
    Citation: Cardiovascular Diabetology 2013 12:32
    Content type: Original investigation Published on:

  2. Peroxisome-proliferator–activated-receptor-γ (PPARγ) acts as a transcriptional regulator of multiple genes involved in glucose and lipid metabolism. In vitro studies showed that activated PPARγ suppresses AT1R...

    Authors: Vedat Tiyerili, Ulrich M Becher, Adem Aksoy, Dieter Lütjohann, Sven Wassmann, Georg Nickenig and Cornelius FH Mueller
    Citation: Cardiovascular Diabetology 2013 12:30
    Content type: Original investigation Published on:

  3. Limited studies have suggested that inflammatory biomarkers play a role in the initiation and progression of atherosclerosis in diabetic patients. This study assesses the effect of inflammatory biomarkers: fib...

    Authors: Marijan Bosevski, Golubinka Bosevska and Lily Stojanovska
    Citation: Cardiovascular Diabetology 2013 12:29
    Content type: Original investigation Published on:

  4. Defective copper regulation is implicated as a causative mechanism of organ damage in diabetes. Treatment with trientine, a divalent-copper-selective chelator, improves arterial and renal structure/function in...

    Authors: Jun Lu, Beau Pontré, Stephen Pickup, Soon Y Choong, Mingming Li, Hong Xu, Gregory D Gamble, Anthony RJ Phillips, Brett R Cowan, Alistair A Young and Garth JS Cooper
    Citation: Cardiovascular Diabetology 2013 12:28
    Content type: Original investigation Published on:

  5. Dysfunctional high-density lipoprotein (HDL) may have pro-inflammatory effects on the endothelial cells,which causes atherosclerosis in type 2 diabetes mellitus (T2DM). HDL is a major carrier of sphingosine-1-...

    Authors: Xunliang Tong, Hui Peng, Donghui Liu, Liang Ji, Chenguang Niu, Jun Ren, Bing Pan, Jianying Hu, Lemin Zheng and Yining Huang
    Citation: Cardiovascular Diabetology 2013 12:27
    Content type: Original investigation Published on:

  6. Diabetes is characterized by profound lipid abnormalities. The objective of this study was to examine changes in concentrations of lipids and apolipoprotein B among participants stratified by glycemic status (...

    Authors: Earl S Ford, Chaoyang Li and Allan Sniderman
    Citation: Cardiovascular Diabetology 2013 12:26
    Content type: Original investigation Published on:

  7. Red blood cells (RBCs) are highly deformable and possess a robust membrane that can withstand shear force. Previous research showed that in diabetic patients, there is a changed RBC ultrastructure, where these...

    Authors: Antoinette V Buys, Mia-Jean Van Rooy, Prashilla Soma, Dirk Van Papendorp, Boguslaw Lipinski and Etheresia Pretorius
    Citation: Cardiovascular Diabetology 2013 12:25
    Content type: Original investigation Published on:

  11. We developed a simple and new insulin resistance index derived from a glucose clamp and a meal tolerance test (MTT) in Japanese patients with type 2 diabetes mellitus.

    Authors: Tsuyoshi Ohkura, Hideki Shiochi, Youhei Fujioka, Keisuke Sumi, Naoya Yamamoto, Kazuhiko Matsuzawa, Shoichiro Izawa, Hiroshi Kinoshita, Hiroko Ohkura, Masahiko Kato, Shin-ichi Taniguchi and Kazuhiro Yamamoto
    Citation: Cardiovascular Diabetology 2013 12:21
    Content type: Original investigation Published on:

  12. Macrovascular diseases (MVD) in type 2 diabetes mellitus (T2DM) are often considered all together, without discriminating the areas involved. The aim of our study was to analyse MVD prevalence in a large popul...

    Authors: Giuseppe Papa, Claudia Degano, Maria P Iurato, Carmelo Licciardello, Raffaella Maiorana and Concetta Finocchiaro
    Citation: Cardiovascular Diabetology 2013 12:20
    Content type: Original investigation Published on:

  13. Diabetes increases the risk of cardiovascular complications including arrhythmias, but the underlying mechanisms remain to be established. Decreased conduction velocity (CV), which is an independent risk facto...

    Authors: Kristine Boisen Olsen, Lene Nygaard Axelsen, Thomas Hartig Braunstein, Charlotte Mehlin Sørensen, Claus B Andersen, Thorkil Ploug, Niels-Henrik Holstein-Rathlou and Morten Schak Nielsen
    Citation: Cardiovascular Diabetology 2013 12:19
    Content type: Original investigation Published on:

  14. The features of carotid atherosclerosis in ketosis-onset diabetes have not been investigated. Our aim was to evaluate the prevalence and clinical characteristics of carotid atherosclerosis in newly diagnosed C...

    Authors: Lian-Xi Li, Cui-Chun Zhao, Ying Ren, Yin-Fang Tu, Jun-Xi Lu, Xing Wu, Wei-Xing Zhang, Jia-An Zhu, Mei-Fang Li, Li-Bo Yu, Yu-Qian Bao and Wei-Ping Jia
    Citation: Cardiovascular Diabetology 2013 12:18
    Content type: Original investigation Published on:

  15. Lipoprotein lipase (LPL) and serum 25-hydroxyvitamin D [25(OH)D] play important roles in the regulation of lipid metabolism. Although dyslipidemia is associated with insulin resistance (IR) and type 2 diabetes...

    Authors: Yifan Huang, Xiaoxia Li, Maoqing Wang, Hua Ning, Lima A, Ying Li and Changhao Sun
    Citation: Cardiovascular Diabetology 2013 12:17
    Content type: Original investigation Published on:

  16. Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expres...

    Authors: Márta Sárközy, Ágnes Zvara, Nóra Gyémánt, Veronika Fekete, Gabriella F Kocsis, Judit Pipis, Gergő Szűcs, Csaba Csonka, László G Puskás, Péter Ferdinandy and Tamás Csont
    Citation: Cardiovascular Diabetology 2013 12:16
    Content type: Original investigation Published on:

  17. The contribution of glycemic variability to macrovascular complications remains unclear. We therefore investigated the association between glycemic variability and cervical and/or intracranial atherosclerosis ...

    Authors: Yifei Mo, Jian Zhou, Mei Li, Yuwei Wang, Yuqian Bao, Xiaojing Ma, Ding Li, Wei Lu, Cheng Hu, Minghua Li and Weiping Jia
    Citation: Cardiovascular Diabetology 2013 12:15
    Content type: Original investigation Published on:

  18. Prediabetes is an independent risk factor for cardiovascular diseases. Mean platelet volume (MPV) can reflect platelet activity, and high MPV is associated with thrombogenic activation and an increased risk of...

    Authors: Masanori Shimodaira, Tomohiro Niwa, Koji Nakajima, Mutsuhiro Kobayashi, Norinao Hanyu and Tomohiro Nakayama
    Citation: Cardiovascular Diabetology 2013 12:14
    Content type: Original investigation Published on:

  19. Hyperglycemia could induce oxidative stress, activate transcription factor nuclear factor kappa B (NF-κB), up-regulate expression of endothelial adhesion molecules, and lead to endothelial injury. Studies have...

    Authors: Minmin Zhu, Jiawei Chen, Hui Jiang and Changhong Miao
    Citation: Cardiovascular Diabetology 2013 12:13
    Content type: Original investigation Published on:

  20. Patients with diabetes mellitus (DM) have an increased risk for periprocedural complications and adverse cardiac events after percutaneous coronary intervention. We addressed the potential for coronary microva...

    Authors: Theodor Baars, Thomas Konorza, Philipp Kahlert, Stefan Möhlenkamp, Raimund Erbel, Gerd Heusch and Petra Kleinbongard
    Citation: Cardiovascular Diabetology 2013 12:12
    Content type: Original investigation Published on:

  21. Osteoprotegerin is a member of the tumor necrosis factor-related family and inhibits RANK stimulation of osteoclast formation as a soluble decoy receptor. The goal of this study was to determine the relationsh...

    Authors: Atsushi Aoki, Miho Murata, Tomoko Asano, Aki Ikoma, Masami Sasaki, Tomoyuki Saito, Taeko Otani, Sachimi Jinbo, Nahoko Ikeda, Masanobu Kawakami and San-e Ishikawa
    Citation: Cardiovascular Diabetology 2013 12:11
    Content type: Original investigation Published on:

  22. High LDL-cholesterol (LDL-C) and glucose levels are risk factors for ischemic heart disease (IHD) in middle-aged diabetic individuals; however, the risk among the elderly, especially the very elderly, is not w...

    Authors: Toshio Hayashi, Atsushi Araki, Seinosuke Kawashima, Hirohito Sone, Hiroshi Watanabe, Takashi Ohrui, Koutaro Yokote, Minoru Takemoto, Kiyoshi Kubota, Mitsuhiko Noda, Hiroshi Noto, Koichiro Ina and Hideki Nomura
    Citation: Cardiovascular Diabetology 2013 12:10
    Content type: Original investigation Published on:

  23. Although an association between low-level environmental heavy metal exposure and the incidence of metabolic syndrome (MS) has been hypothesized, little research on this topic has been conducted on a population...

    Authors: Sang Youl Rhee, You-Cheol Hwang, Jeong-taek Woo, Dong Hyun Sinn, Sang Ouk Chin, Suk Chon and Young Seol Young Seol Kim
    Citation: Cardiovascular Diabetology 2013 12:9
    Content type: Original investigation Published on:

  24. Postprandial hyperlipidemia impairs endothelial function and participates in the development of atherosclerosis. We investigated the postprandial effects of a dipeptidyl peptidase IV inhibitor, alogliptin, on ...

    Authors: Yoko Noda, Toru Miyoshi, Hiroki Oe, Yuko Ohno, Kazufumi Nakamura, Norihisa Toh, Kunihisa Kohno, Hiroshi Morita, Kengo Kusano and Hiroshi Ito
    Citation: Cardiovascular Diabetology 2013 12:8
    Content type: Original investigation Published on:

  25. Vitamin K has been related to glucose metabolism, insulin sensitivity and diabetes. Because inflammation underlies all these metabolic conditions, it is plausible that the potential role of vitamin K in glucos...

    Authors: Martí Juanola-Falgarona, Jordi Salas-Salvadó, Ramon Estruch, Maria P Portillo, Rosa Casas, Jonatan Miranda, Miguel A Martínez-González and Mònica Bulló
    Citation: Cardiovascular Diabetology 2013 12:7
    Content type: Original investigation Published on:

  26. Fibulin-1 is one of a few extracellular matrix proteins present in blood in high concentrations. We aimed to define the relationship between plasma fibulin-1 levels and risk markers of cardiovascular disease.

    Authors: Alexandra Scholze, Else-Marie Bladbjerg, Johannes J Sidelmann, Axel CP Diederichsen, Hans Mickley, Mads Nybo, W Scott Argraves, Peter Marckmann and Lars M Rasmussen
    Citation: Cardiovascular Diabetology 2013 12:6
    Content type: Original investigation Published on:

  27. The Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome (JAPAN-ACS) trial demonstrated that early aggressive statin therapy in patients with ACS significantly reduces plaque volume (PV...

    Authors: Yoshifumi Fukushima, Hiroyuki Daida, Takeshi Morimoto, Takatoshi Kasai, Katsumi Miyauchi, Sho-ichi Yamagishi, Masayoshi Takeuchi, Takafumi Hiro, Takeshi Kimura, Yoshihisa Nakagawa, Masakazu Yamagishi, Yukio Ozaki and Masunori Matsuzaki
    Citation: Cardiovascular Diabetology 2013 12:5
    Content type: Original investigation Published on:

  28. Although a decrease in serum potassium level has been suggested to be a fairly common observation in acute coronary syndrome (ACS), there have so far been no definitive reports directly demonstrating the trans...

    Authors: Hiroshi Sekiyama, Tomohisa Nagoshi, Kimiaki Komukai, Masato Matsushima, Daisuke Katoh, Kazuo Ogawa, Kosuke Minai, Takayuki Ogawa and Michihiro Yoshimura
    Citation: Cardiovascular Diabetology 2013 12:4
    Content type: Original investigation Published on:

  29. To compare the incidence of cardiovascular events and mortality in patients with type 2 diabetes mellitus treated with sitagliptin or non-sitagliptin comparators.

    Authors: Samuel S Engel, Gregory T Golm, Deborah Shapiro, Michael J Davies, Keith D Kaufman and Barry J Goldstein
    Citation: Cardiovascular Diabetology 2013 12:3
    Content type: Original investigation Published on:

  31. Fluctuations in blood glucose level cause endothelial dysfunction and play a critical role in onset and/or progression of atherosclerosis. We hypothesized that fluctuation in blood glucose levels correlate wit...

    Authors: Keiichi Torimoto, Yosuke Okada, Hiroko Mori and Yoshiya Tanaka
    Citation: Cardiovascular Diabetology 2013 12:1
    Content type: Original investigation Published on:

  32. Cardiovascular risk factors (CVRF) may cluster in type 1 diabetes, analogously to the metabolic syndrome described in type 2 diabetes. The threshold of HbA1c above which lipid variables start changing behavior is...

    Authors: Fernando MA Giuffrida, Alexis D Guedes, Eloa R Rocco, Denise B Mory, Patricia Dualib, Odelisa S Matos, Reine M Chaves-Fonseca, Roberta A Cobas, Carlos Antonio Negrato, Marilia B Gomes and Sergio A Dib
    Citation: Cardiovascular Diabetology 2012 11:156
    Content type: Original investigation Published on:

  33. The appropriateness of the routine performance of an oral glucose tolerance test (OGTT) to screen for diabetes mellitus (DM) during acute coronary syndrome hospitalization is still under debate.

    Authors: Yicong Ye, Hongzhi Xie, Xiliang Zhao and Shuyang Zhang
    Citation: Cardiovascular Diabetology 2012 11:155
    Content type: Original investigation Published on:

  34. Elevation of cardiac troponin has been documented in multiple settings without acute coronary syndrome. However, its impact on long-term cardiac outcomes in the context of acute decompensated diabetes remains ...

    Authors: Anthony Eubanks, Farhan Raza, Mohamad Alkhouli, April N Glenn, Carol Homko, Abul Kashem and Alfred Bove
    Citation: Cardiovascular Diabetology 2012 11:154
    Content type: Original investigation Published on:

  35. In diabetes, a variety of pro-inflammatory cellular changes has been found in various cell types, including monocytes which are known to be involved in all the phases of atherogenesis. Angiotensin II (Ang II) ...

    Authors: Franca Marino, Andrea Maria Maresca, Marco Cosentino, Luana Castiglioni, Emanuela Rasini, Christian Mongiardi, Ramona C Maio, Massimiliano Legnaro, Laura Schembri, Francesco Dentali, Anna Maria Grandi and Luigina Guasti
    Citation: Cardiovascular Diabetology 2012 11:153
    Content type: Original investigation Published on:

  36. Diabetic patients experience stimulated coagulation and dysfibrinolysis, which is associated with an increased risk of cardiovascular events. This imbalance may precede the manifest diagnosis. We investigated ...

    Authors: Jenny Hernestål-Boman, Margareta Norberg, Jan-Hakan Jansson, Mats Eliasson, Jan W Eriksson, Bernt Lindahl and Lars Johansson
    Citation: Cardiovascular Diabetology 2012 11:152
    Content type: Original investigation Published on:

  37. Several peptides, named adipokines, are produced by the adipose tissue. Among those, adiponectin (AD) is the most abundant. AD promotes peripheral insulin sensitivity, inhibits liver gluconeogenesis and displa...

    Authors: Samuele Baldasseroni, Alessandro Antenore, Claudia Di Serio, Francesco Orso, Giuseppe Lonetto, Nadia Bartoli, Alice Foschini, Andrea Marella, Alessandra Pratesi, Salvatore Scarantino, Stefano Fumagalli, Matteo Monami, Edoardo Mannucci, Niccolò Marchionni and Francesca Tarantini
    Citation: Cardiovascular Diabetology 2012 11:151
    Content type: Original investigation Published on:

  38. Neointimal formation plays an important role in the pathogenesis of coronary restenosis after percutaneous coronary intervention (PCI), especially in patients with diabetes mellitus. Recently, some studies hav...

    Authors: Jingsheng Guo, Dongye Li, Shiru Bai, Tongda Xu, Zhongmin Zhou and Yanbin Zhang
    Citation: Cardiovascular Diabetology 2012 11:150
    Content type: Study protocol Published on:

  39. Low concentrations of plasma vitamin D (25(OH)D) have been associated with the development of metabolic syndrome (MetS), obesity, diabetes and cardiovascular disease. The objective of this study was to quantif...

    Authors: Alba Guasch, Mònica Bulló, Antoni Rabassa, Anna Bonada, Daniel Del Castillo, Fàtima Sabench and Jordi Salas-Salvadó
    Citation: Cardiovascular Diabetology 2012 11:149
    Content type: Original investigation Published on:

  40. Patients with type 2 diabetes have 2–4 times greater risk for cardiovascular morbidity and mortality than those without, and this is even further aggravated if they also suffer from hypertension. Unfortunately...

    Authors: Anselm K Gitt, Roland E Schmieder, Eva Duetting, Peter Bramlage, Steffen Schneider and Diethelm Tschöpe
    Citation: Cardiovascular Diabetology 2012 11:148
    Content type: Study protocol Published on:

  41. Endothelial progenitor cells (EPCs) are responsible for angiogenesis and maintenance of microvascular integrity, the number of EPCs is correlated with oxidative stress. Their relation to myocardial dysfunction...

    Authors: Chun Ting Zhao, Mei Wang, Chung Wah Siu, Ying Long Hou, Tian Wang, Hung Fat Tse and Kai Hang Yiu
    Citation: Cardiovascular Diabetology 2012 11:147
    Content type: Original investigation Published on:

  42. The purpose of this study was to determine the sex-specific pattern of pediatric cardiometabolic risk with principal component analysis, using several biological, behavioral and parental variables in a large c...

    Authors: Mark D Peterson, Dongmei Liu, Heidi B IglayReger, William A Saltarelli, Paul S Visich and Paul M Gordon
    Citation: Cardiovascular Diabetology 2012 11:146
    Content type: Original investigation Published on:

  43. Patients with type 1 diabetes have a substantial risk of developing cardiovascular complications early in life. We aimed to explore the role of insulin sensitivity (Si) as an early factor of atherosclerosis in yo...

    Authors: Björn Rathsman, Stefan Rosfors, Åke Sjöholm and Thomas Nyström
    Citation: Cardiovascular Diabetology 2012 11:145
    Content type: Original investigation Published on:

  44. Endothelial dysfunction is a well documented evidence for the onset of atherosclerosis and other cardiovascular diseases. Lipids disorder is among the main risk factors for endothelial dysfunction in these dis...

    Authors: Dai Tian, Yanyan Qiu, Yongkun Zhan, Xiaobo Li, Xiuling Zhi, Xinhong Wang, Lianhua Yin and Yanxia Ning
    Citation: Cardiovascular Diabetology 2012 11:144
    Content type: Original investigation Published on:

  45. The role of systemic and myocardial adiponectin (ADN) in dilated cardiomyopathy is still debated. We tested the regulation of both systemic and myocardial ADN and the relationship with AMP-activated protein ki...

    Authors: Chiara Caselli, Vincenzo Lionetti, Manuela Cabiati, Tommaso Prescimone, Giovanni D Aquaro, Virginia Ottaviano, Fabio Bernini, Letizia Mattii, Silvia Del Ry and Daniela Giannessi
    Citation: Cardiovascular Diabetology 2012 11:143
    Content type: Original investigation Published on:

  46. To assess the efficacy and safety of adding liraglutide to established insulin therapy in poorly controlled Chinese subjects with type 2 diabetes and abdominal obesity compared with increasing insulin dose.

    Authors: Chun-jun Li, Jing Li, Qiu-mei Zhang, Lin Lv, Rui Chen, Chun-feng Lv, Pei Yu and De-min Yu
    Citation: Cardiovascular Diabetology 2012 11:142
    Content type: Original investigation Published on:

  47. Central arterial stiffness represents a well-established predictor of cardiovascular disease. Decreased circulating endothelial progenitor cells (EPCs), increased asymmetric dimethyl-arginine (ADMA) levels, tr...

    Authors: Ioannis Protopsaltis, Stefanos Foussas, Angeliki Angelidi, Angelos Gritzapis, Theodoros Ν Sergentanis, Spyros Matsagos, Konstantinos Tzirogiannis, Georgios I Panoutsopoulos, Georgios Dimitriadis, Sotirios Raptis and Andreas Melidonis
    Citation: Cardiovascular Diabetology 2012 11:141
    Content type: Original investigation Published on:

  48. All fibrates are peroxisome proliferators-activated receptors (PPARs)-alpha agonists with ability to decrease triglyceride and increase high density lipoprotein- cholesterol (HDL-C). However, bezafibrate has a...

    Authors: Alexander Tenenbaum and Enrique Z Fisman
    Citation: Cardiovascular Diabetology 2012 11:140
    Content type: Review Published on:

  49. Telmisartan is a well-established angiotensin II type 1 receptor blocker that improves insulin sensitivity in animal models of obesity and insulin resistance, as well as in humans. Telmisartan has been reporte...

    Authors: Asuka Shiota, Michio Shimabukuro, Daiju Fukuda, Takeshi Soeki, Hiromi Sato, Etsuko Uematsu, Yoichiro Hirata, Hirotsugu Kurobe, Norikazu Maeda, Hiroshi Sakaue, Hiroaki Masuzaki, Iichiro Shimomura and Masataka Sata
    Citation: Cardiovascular Diabetology 2012 11:139
    Content type: Original investigation Published on:

  50. The genomic region at 9p21 chromosome near the CDKN2A/CDKN2B genes is associated with type 2 diabetes(T2D) and cardiovascular disease(CVD). The effect of the 9p21 locus on long-term mortality in patients with T2D...

    Authors: Gijs WD Landman, Jana V van Vliet-Ostaptchouk, Nanne Kleefstra, Kornelis JJ van Hateren, Iefke Drion, Klaas H Groenier, Rijk OB Gans, Harold Snieder, Marten H Hofker and Henk JG Bilo
    Citation: Cardiovascular Diabetology 2012 11:138
    Content type: Original investigation Published on:
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Cardiovascular Diabetology

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