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  1. Sulfonylureas (SUs) are commonly used in the treatment of type 2 diabetes (T2DM), usually as second-line treatment after the failure of metformin. However, SUs are associated with poor durability, hypoglycemia...

    Authors: Martin Ridderstråle, Robbyna Svaerd, Cordula Zeller, Gabriel Kim, Hans J Woerle and Uli C Broedl
    Citation: Cardiovascular Diabetology 2013 12:129
    Content type: Study protocol Published on:

  2. This study aimed to evaluate the efficacy of mesenchymal stem cell (MSC) transplantation to mitigate abnormalities in cardiac-specific and systemic metabolism mediated by a combination of a myocardial infarcti...

    Authors: Curtis C Hughey, Lianli Ma, Freyja D James, Deanna P Bracy, Zhizhang Wang, David H Wasserman, Jeffrey N Rottman, Dustin S Hittel and Jane Shearer
    Citation: Cardiovascular Diabetology 2013 12:128
    Content type: Original investigation Published on:

  3. Symptoms of heart failure with preserved left ventricular systolic function are common among patients undergoing peritoneal dialysis (PD). Epicardial fat (EpF) is an ectopic fat depot with possible paracrine o...

    Authors: Heng-Hsu Lin, Jen-Kuang Lee, Chung-Yi Yang, Yu-Chung Lien, Jenq-Wen Huang and Cho-Kai Wu
    Citation: Cardiovascular Diabetology 2013 12:127
    Content type: Original investigation Published on:

  4. Novel and robust cardiovascular (CV) markers are needed to improve CV morbidity and mortality risk prediction in type 2 diabetes (T2D). We assessed the long term predictive value of 4 novel CV risk markers for...

    Authors: Anne Pernille Ofstad, Lars Gullestad, Elsa Orvik, Svend Aakhus, Knut Endresen, Thor Ueland, PÃ¥l Aukrust, Morten W Fagerland, KÃ¥re I Birkeland and Odd Erik Johansen
    Citation: Cardiovascular Diabetology 2013 12:126
    Content type: Original investigation Published on:

  5. Advanced glycation end products (AGEs) and receptor RAGE interaction play a role in diabetic vascular complications. Inhibition of dipeptidyl peptidase-4 (DPP-4) is a potential therapeutic target for type 2 di...

    Authors: Yuji Ishibashi, Takanori Matsui, Sayaka Maeda, Yuichiro Higashimoto and Sho-ichi Yamagishi
    Citation: Cardiovascular Diabetology 2013 12:125
    Content type: Original investigation Published on:

  6. Expression and activity of the fibroblast growth factor (FGF) 21 hormone-like protein are associated with development of several metabolic disorders. This study was designed to investigate whether serum FGF21 ...

    Authors: Yun Shen, Xiaojing Ma, Jian Zhou, Xiaoping Pan, Yaping Hao, Mi Zhou, Zhigang Lu, Meifang Gao, Yuqian Bao and Weiping Jia
    Citation: Cardiovascular Diabetology 2013 12:124
    Content type: Original investigation Published on:

  7. Intracellular calcium (Ca2+) coordinates the cardiac contraction cycle and is dysregulated in diabetic cardiomyopathy. Treatment with triethylenetetramine (TETA), a divalent-copper-selective chelator, improves ca...

    Authors: Lin Zhang, Marie-Louise Ward, Anthony RJ Phillips, Shaoping Zhang, John Kennedy, Bernard Barry, Mark B Cannell and Garth JS Cooper
    Citation: Cardiovascular Diabetology 2013 12:123
    Content type: Original investigation Published on:

  8. Authors: Joris van Ark, Hans-Peter Hammes, Marcory CRF van Dijk, Chris PH Lexis, Iwan CC van der Horst, Clark J Zeebregts, Marc G Vervloet, Bruce HR Wolffenbuttel, Harry van Goor and Jan-Luuk Hillebrands
    Citation: Cardiovascular Diabetology 2013 12:120
    Content type: Erratum Published on:

    The original article was published in Cardiovascular Diabetology 2013 12:116

  9. Non-invasive measurements of 24 hour ambulatory central aortic systolic pressure (24 h-CASP) and central pulse pressure (24 h-CPP) are now feasible. We evaluate the relationship between 24 h central blood pres...

    Authors: Simone Theilade, Maria Lajer, Tine Willum Hansen, Christel Joergensen, Frederik Persson, Gudbjörg Andrésdottir, Henrik Reinhard, Stine Elkjær Nielsen, Peter Lacy, Bryan Williams and Peter Rossing
    Citation: Cardiovascular Diabetology 2013 12:122
    Content type: Original investigation Published on:

  10. Cardiovascular risk stratification of asymptomatic diabetic patients is important and remains a difficult clinical problem. Our aim was to test the hypothesis that coronary flow reserve (CFR) assessed by nonin...

    Authors: Takayuki Kawata, Masao Daimon, Rei Hasegawa, Tomohiko Toyoda, Tai Sekine, Toshiharu Himi, Daigaku Uchida, Sakiko Miyazaki, Kuniaki Hirose, Ryoko Ichikawa, Masaki Maruyama, Hiromasa Suzuki and Hiroyuki Daida
    Citation: Cardiovascular Diabetology 2013 12:121
    Content type: Original investigation Published on:

  11. Nicotinamide phosphoribosyltransferase (NAMPT) is the limiting enzyme in one of pathways of synthesis of Nicotinamide Adenine Dinucleotide, a redox coenzyme. NAMPT is considered as an insulin-mimetic factor an...

    Authors: Pedro Saddi-Rosa, Carolina Soares Oliveira, Felipe Crispim, Fernando MA Giuffrida, Valter Correia de Lima, José Gilberto Vieira, Alessandro Doria, Gilberto Velho and André Fernandes Reis
    Citation: Cardiovascular Diabetology 2013 12:119
    Content type: Original investigation Published on:

  12. Limitations of the currently recommended stepwise treatment pathway for type 2 diabetes mellitus (T2DM), especially the failure of monotherapies to maintain good glycemic control, have prompted use of early, m...

    Authors: Li-Nong Ji, Chang-Yu Pan, Ju-Ming Lu, Hong Li, Qiang Li, Qi-Fu Li, Yong-De Peng, Hao-Ming Tian, Chen Yao, Zhi-Gang Zhao, Ru-Ya Zhang, Xiang-Ling Wang and Lei Wang
    Citation: Cardiovascular Diabetology 2013 12:118
    Content type: Study protocol Published on:

  13. GLP-1 is an incretine hormone which gets secreted from intestinal L-cells in response to nutritional stimuli leading to pancreatic insulin secretion and suppression of glucagon release. GLP-1 further inhibits ...

    Authors: Katja Piotrowski, Melanie Becker, Julia Zugwurst, Ingeborg Biller-Friedmann, Gerald Spoettl, Martin Greif, Alexander W Leber, Alexander Becker, Rüdiger P Laubender, Corinna Lebherz, Burkhard Goeke, Nikolaus Marx, Klaus G Parhofer and Michael Lehrke
    Citation: Cardiovascular Diabetology 2013 12:117
    Content type: Original investigation Published on:

  14. Diabetes is associated with a high incidence of macrovascular disease (MVD), including peripheral and coronary artery disease. Circulating soluble-Klotho (sKlotho) is produced in the kidney and is a putative a...

    Authors: Joris van Ark, Hans-Peter Hammes, Marcory C R F van Dijk, Marc G Vervloet, Bruce H R Wolffenbuttel, Harry van Goor and Jan-Luuk Hillebrands
    Citation: Cardiovascular Diabetology 2013 12:116
    Content type: Original investigation Published on:

    The Erratum to this article has been published in Cardiovascular Diabetology 2013 12:120

  15. We used Laser Doppler Fluximetry (LDF) to define "normal" endothelial function in a large cohort of healthy children and adolescents and to evaluate skin microcirculation in paediatric patients with type 1 dia...

    Authors: Mirjam Heimhalt-El Hamriti, Corinna Schreiver, Anja Noerenberg, Julia Scheffler, Ulrike Jacoby, Dieter Haffner and Dagmar-C Fischer
    Citation: Cardiovascular Diabetology 2013 12:115
    Content type: Original investigation Published on:

  16. Cardiac nestin(+) cells exhibit properties of a neural progenitor/stem cell population characterized by the de novo synthesis of neurofilament-M in response to ischemic injury and 6-hydroxydopamine administration...

    Authors: Andreanne Chabot, Marc-Andre Meus, Vanessa Hertig, Natacha Duquette and Angelino Calderone
    Citation: Cardiovascular Diabetology 2013 12:114
    Content type: Original investigation Published on:

  17. Little or no research has determined the effect of vitamin D3 supplementation in conjunction with pharmacological and non-pharmacological approaches in the diabetes mellitus type 2 (DMT2) patients. The objecti...

    Authors: Khalid M Alkharfy, Nasser M Al-Daghri, Shaun B Sabico, Abdulaziz Al-Othman, Osama Moharram, Majed S Alokail, Yousef Al-Saleh, Sudhesh Kumar and George P Chrousos
    Citation: Cardiovascular Diabetology 2013 12:113
    Content type: Original investigation Published on:

  18. Qualitative alterations of lipoproteins underlie the high incidence of atherosclerosis in diabetes. The objective of this study was to assess the impact of low-density lipoprotein (LDL) subfraction phenotype o...

    Authors: Jose Luis Sánchez-Quesada, Irene Vinagre, Elena De Juan-Franco, Juan Sánchez-Hernández, Rosa Bonet-Marques, Francisco Blanco-Vaca, Jordi Ordóñez-Llanos and Antonio Pérez
    Citation: Cardiovascular Diabetology 2013 12:112
    Content type: Original investigation Published on:

  19. Activation of RhoA/Rho-kinase (ROCK) is increasingly implicated in acute vasospasm and chronic vasoconstriction in major organ systems. Therefore we aimed to ascertain whether an increase in ROCK activity play...

    Authors: James T Pearson, Mathew J Jenkins, Amanda J Edgley, Takashi Sonobe, Mandar Joshi, Mark T Waddingham, Yutaka Fujii, Daryl O Schwenke, Hirotsugu Tsuchimochi, Misa Yoshimoto, Keiji Umetani, Darren J Kelly and Mikiyasu Shirai
    Citation: Cardiovascular Diabetology 2013 12:111
    Content type: Original investigation Published on:

  20. Low-grade albuminuria is associated with cardiovascular risk factors and mortality. Our aim was to investigate the association between low-grade albuminuria and carotid atherosclerotic lesions in community-bas...

    Authors: Mei-Fang Li, Yin-Fang Tu, Lian-Xi Li, Jun-Xi Lu, Xue-Hong Dong, Li-Bo Yu, Rong Zhang, Yu-Qian Bao, Wei-Ping Jia and Ren-Ming Hu
    Citation: Cardiovascular Diabetology 2013 12:110
    Content type: Original investigation Published on:

  21. Left ventricular hypertrophy has multiple aetiologies including diabetes and genetic factors. We aimed to identify genetic variants predicting left ventricular hypertrophy in diabetic individuals.

    Authors: Helen M Parry, Louise A Donnelly, Natalie Van Zuydam, Alexander SF Doney, Douglas HJ Elder, Andrew D Morris, Alan D Struthers, Colin NA Palmer and Chim C Lang
    Citation: Cardiovascular Diabetology 2013 12:109
    Content type: Original investigation Published on:

  22. Circulatory and tissue renin-angiotensin systems (RAS) play a central role in cardiovascular (CV) and renal pathophysiology, making RAS inhibition a logical therapeutic approach in the prevention of CV and ren...

    Authors: Samir G Mallat
    Citation: Cardiovascular Diabetology 2013 12:108
    Content type: Review Published on:

  23. The arterial system in diabetic patients is characterized by generalized non-atherosclerotic alterations in the vascular extracellular matrix causing increased arterial stiffness compared with subjects without...

    Authors: Esben Laugesen, Pernille Høyem, Jens Sandahl Christiansen, Søren Tang Knudsen, Klavs Würgler Hansen, W Scott Argraves, Troels Krarup Hansen, Per Løgstrup Poulsen and Lars Melholt Rasmussen
    Citation: Cardiovascular Diabetology 2013 12:107
    Content type: Original investigation Published on:

  24. Insulin resistance (IR) is the key feature of the metabolic syndrome (MetS); its association with peripheral arterial disease (PAD) is unclear. We hypothesized that IR is associated with both the MetS and sono...

    Authors: Alexander Vonbank, Christoph H Saely, Philipp Rein and Heinz Drexel
    Citation: Cardiovascular Diabetology 2013 12:106
    Content type: Original investigation Published on:

  25. Adipokines, including adipocyte fatty acid-binding protein (A-FABP), have been demonstrated to be involved in the pathogenesis of atherosclerosis. In the present study, we investigated the association of circu...

    Authors: Chi-Lun Huang, Yen-Wen Wu, Chih-Cheng Wu, Lin Lin, Yu-Chin Wu, Pei-Ying Hsu, Yuh-Shiun Jong and Wei-Shiung Yang
    Citation: Cardiovascular Diabetology 2013 12:105
    Content type: Original investigation Published on:

  26. Dyslipidemia is a common complication in patients with diabetes and is involved in being prone to cardiovascular disease. The risk of coronary artery disease is known to be lower in light-to-moderate drinkers ...

    Authors: Tomoko Shimomura and Ichiro Wakabayashi
    Citation: Cardiovascular Diabetology 2013 12:104
    Content type: Original investigation Published on:

  27. Genetic variants of the FTO gene rs9939609 A/T and the MC4R gene rs17782313 C/T have been associated with obesity. Individuals with mutations in MC4R gene have lower blood pressure (BP), independently of obesity....

    Authors: Aline Marcadenti, Flavio D Fuchs, Ursula Matte, Fernanda Sperb, Leila B Moreira and Sandra C Fuchs
    Citation: Cardiovascular Diabetology 2013 12:103
    Content type: Original investigation Published on:

  28. Patients with type 2 diabetes are at increased risk for both, left ventricular (LV)-dilatation and myocardial infarction (MI) following the rupture of a vulnerable plaque. This study investigated the to date i...

    Authors: Mathias Burgmaier, Michael Frick, Ana Liberman, Simone Battermann, Martin Hellmich, Walter Lehmacher, Agnes Jaskolka, Nikolaus Marx and Sebastian Reith
    Citation: Cardiovascular Diabetology 2013 12:102
    Content type: Original investigation Published on:

  29. Exercise causes physiological cardiac hypertrophy and benefits the diabetic heart. Mammalian switch-independent 3A (mSin3A) and histone deacetylases (HDACs) 1 and 2 regulate hypertrophic genes through associat...

    Authors: Emily J Cox and Susan A Marsh
    Citation: Cardiovascular Diabetology 2013 12:101
    Content type: Original investigation Published on:

  30. Icosapent ethyl (IPE) is a high-purity prescription form of eicosapentaenoic acid (EPA) ethyl ester indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe (≥500 mg/dL)...

    Authors: Eliot A Brinton, Christie M Ballantyne, Harold E Bays, John J Kastelein, Rene A Braeckman and Paresh N Soni
    Citation: Cardiovascular Diabetology 2013 12:100
    Content type: Original investigation Published on:

  31. Glucose intolerance and cardiovascular complications are major symptoms in patients with diabetes. Many therapies have proven beneficial in treating diabetes in animals by protecting the cardiovascular system ...

    Authors: Yi-Jin Ho, Wen-Pin Chen, Tzong-Cherng Chi, Ching-Chia Chang Chien, An-Sheng Lee, Hsi-Lin Chiu, Yueh-Hsiung Kuo and Ming-Jai Su
    Citation: Cardiovascular Diabetology 2013 12:99
    Content type: Original investigation Published on:

  32. Previous reports have clearly indicated a significant relationship between hemoglobin (Hb) A1c change from one visit to the next and microvascular complications, especially nephropathy (albuminuria and albuminuri...

    Authors: Giuseppe Penno, Anna Solini, Giacomo Zoppini, Emanuela Orsi, Cecilia Fondelli, Gianpaolo Zerbini, Susanna Morano, Franco Cavalot, Olga Lamacchia, Roberto Trevisan, Monica Vedovato and Giuseppe Pugliese
    Citation: Cardiovascular Diabetology 2013 12:98
    Content type: Original investigation Published on:

  33. It has been reported that hyperglycemia following hypoglycemia produces an ischemia-reperfusion-like effect in type 1 diabetes. In this study the possibility that GLP-1 has a protective effect on this phenomen...

    Authors: Antonio Ceriello, Anna Novials, Emilio Ortega, Silvia Canivell, Gemma Pujadas, Lucia La Sala, Loredana Bucciarelli, Maurizio Rondinelli and Stefano Genovese
    Citation: Cardiovascular Diabetology 2013 12:97
    Content type: Original investigation Published on:

  34. Glycemic memory of endothelial cells is an effect of long-lasting hyperglycemia and is a cause of various diabetics complications, that arises despite of the treatment targeted towards returning low glucose le...

    Authors: Marta Targosz-Korecka, Grzegorz D Brzezinka, Katarzyna E Malek, Ewa Stȩpień and Marek Szymonski
    Citation: Cardiovascular Diabetology 2013 12:96
    Content type: Original investigation Published on:

  35. Patients with type 2 diabetes (T2D) are at elevated risk for cardiovascular disease (CVD) events and mortality. Recent studies have assessed the impact of genetic variants affecting high-density lipoprotein ch...

    Authors: Laura M Raffield, Amanda J Cox, Fang-Chi Hsu, Maggie C-Y Ng, Carl D Langefeld, J Jeffrey Carr, Barry I Freedman and Donald W Bowden
    Citation: Cardiovascular Diabetology 2013 12:95
    Content type: Original investigation Published on:

  36. Type 2 diabetes mellitus (T2DM) is associated with subclinical myocardial injury although the underlying mechanism is uncertain. We postulated that arterial stiffness, endothelial dysfunction and subclinical a...

    Authors: Kai-Hang Yiu, Chun-Ting Zhao, Yan Chen, Chung-Wah Siu, Yap-Hang Chan, Kui-Kai Lau, Shasha Liu, Chu-Pak Lau and Hung-Fat Tse
    Citation: Cardiovascular Diabetology 2013 12:94
    Content type: Original investigation Published on:

  37. Increased arterial stiffness is a cardiovascular outcome of metabolic syndrome (MetS). The chromosome 9p21 locus has been identified as a major locus for risk of coronary artery disease (CAD). The single nucle...

    Authors: Suphawadee Phababpha, Upa Kukongviriyapan, Poungrat Pakdeechote, Laddawan Senggunprai, Veerapol Kukongviriyapan, Chatri Settasatian, Pyatat Tatsanavivat, Phongsak Intharaphet, Vichai Senthong, Nantarat Komanasin, Nongnuch Settasatian and Stephen E Greenwald
    Citation: Cardiovascular Diabetology 2013 12:93
    Content type: Original investigation Published on:

  38. Hyperglycemia, a risk factor for development of cardiovascular disease, causes endothelial dysfunction. Alpha-glucosidase inhibitors (α-GIs) improve postprandial hyperglycemia (PPHG) and may have favorable eff...

    Authors: Daisuke Kitano, Masaaki Chiku, Yuxin Li, Yasuo Okumura, Daisuke Fukamachi, Tadateru Takayama, Takafumi Hiro, Satoshi Saito and Atsushi Hirayama
    Citation: Cardiovascular Diabetology 2013 12:92
    Content type: Original investigation Published on:

  39. Diabetic patients, through incompletely understood mechanisms, endure exacerbated ischemic heart injury compared to non-diabetic patients. Intermedin (IMD) is a novel calcitonin gene-related peptide (CGRP) sup...

    Authors: Hong Li, Yunfei Bian, Nana Zhang, Jia Guo, Cheng Wang, Wayne Bond Lau and Chuanshi Xiao
    Citation: Cardiovascular Diabetology 2013 12:91
    Content type: Original investigation Published on:

  41. The increase in fructose consumption is paralleled by a higher incidence of metabolic syndrome, and consequently, cardiovascular disease mortality. We examined the effects of 8 weeks of low intensity exercise ...

    Authors: Eduardo Morvan, Nathalia Edviges Alves Lima, Jacqueline Freire Machi, Cristiano Mostarda, Kátia De Angelis, Maria Cláudia Irigoyen, Rogério Brandão Wichi, Bruno Rodrigues and Laura Beatriz Mesiano Maifrino
    Citation: Cardiovascular Diabetology 2013 12:89
    Content type: Original investigation Published on:

  42. Although many Asian type 2 diabetic patients have been considered to be not obese and have low capacity of insulin secretion, the proportion of obese patients with visceral fat accumulation has increased in re...

    Authors: Hirofumi Nagao, Susumu Kashine, Hitoshi Nishizawa, Takuya Okada, Takekazu Kimura, Ayumu Hirata, Shiro Fukuda, Junji Kozawa, Norikazu Maeda, Tetsuhiro Kitamura, Tetsuyuki Yasuda, Kohei Okita, Toshiyuki Hibuse, Mamiko Tsugawa, Akihisa Imagawa, Tohru Funahashi…
    Citation: Cardiovascular Diabetology 2013 12:88
    Content type: Original investigation Published on:

  43. Clopidogrel and aspirin are antiplatelet agents that are recommended to reduce the risk of recurrent stroke and other cardiovascular events. Combination therapy of clopidogrel and aspirin has been shown to inc...

    Authors: Yasuo Takahashi, Yayoi Nishida, Tomohiro Nakayama and Satoshi Asai
    Citation: Cardiovascular Diabetology 2013 12:87
    Content type: Original investigation Published on:

  44. In the general population, metabolic syndrome (MetS) is correlated with visceral fat and a risk factor for cardiovascular disease (CVD); however, little is known about the significance of abdominal fat and its...

    Authors: Jenq-Wen Huang, Chung-Yi Yang, Hon-Yen Wu, Kao-Lang Liu, Chi-Ting Su, Cho-Kai Wu, Jen-Kuang Lee, Chih-Kang Chiang, Hui-Teng Cheng, Yu-Chung Lien and Kuan-Yu Hung
    Citation: Cardiovascular Diabetology 2013 12:86
    Content type: Original investigation Published on:

  45. Although cardiac autonomic neuropathy is one of major complications of diabetes mellitus (DM), anatomical data on cardiac innervation of diabetic animal models is scant and controversial. We performed this stu...

    Authors: Darius Batulevicius, Thomas Frese, Elmar Peschke, Dainius H Pauza and Vaida Batuleviciene
    Citation: Cardiovascular Diabetology 2013 12:85
    Content type: Original investigation Published on:

  46. Although dipyridamole is a widely used pharmacological stress agent, the direct effects on myocardium are not entirely known. Diabetic cardiomyopathy can be investigated by 2D-strain echocardiography. The aim ...

    Authors: Thomas Cognet, Paul-Louis Vervueren, Laurent Dercle, Delphine Bastié, Rainui Richaud, Matthieu Berry, Pauline Marchal, Matthieu Gautier, Audrey Fouilloux, Michel Galinier, Didier Carrié, Pierre Massabuau, Isabelle Berry and Olivier Lairez
    Citation: Cardiovascular Diabetology 2013 12:84
    Content type: Original investigation Published on:

  47. Physical activity has been associated with lower cardiovascular mortality in people with diabetes, but how diabetes severity influence this association has not been extensively studied.

    Authors: Børge Moe, Liv Berit Augestad and Tom IL Nilsen
    Citation: Cardiovascular Diabetology 2013 12:83
    Content type: Original investigation Published on:

  48. Dyslipidemia is a major risk factor for cardiovascular (CV) disease – the primary cause of death, worldwide. Although reducing levels of low-density lipoprotein-cholesterol can significantly reduce CV risk, a ...

    Authors: Jean-Charles Fruchart
    Citation: Cardiovascular Diabetology 2013 12:82
    Content type: Review Published on:

  50. The term cardiometabolic disease encompasses a range of lifestyle-related conditions, including Metabolic syndrome (MetS) and type 2 diabetes (T2D), that are characterized by different combinations of cardiova...

    Authors: Henry Ginsberg
    Citation: Cardiovascular Diabetology 2013 12(Suppl 1):S1
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

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