Felber JP, Golay A: Pathways from obesity to diabetes. Int J Obes. 2002, 26 (Suppl 2): S39-45. 10.1038/sj.ijo.0802126.
Article
CAS
Google Scholar
Lean ME: Pathophysiology of obesity. Proc Nutr Soc. 2000, 59: 331-6.
Article
CAS
PubMed
Google Scholar
Astrup A, Finer N: Redefining Type 2 diabetes: 'Diabesity' or 'Obesity Dependent Diabetes Mellitus'?. Obes Rev. 2000, 1: 57-59. 10.1046/j.1467-789x.2000.00013.x.
Article
CAS
PubMed
Google Scholar
Burke JP, Williams K, Gaskill SP, Hazuda HP, Haffner SM, Stern MP: Rapid rise in the incidence of type 2 diabetes from 1987 to 1996: results from the San Antonio Heart Study. Arch Intern Med. 1999, 159: 1450-1456. 10.1001/archinte.159.13.1450.
Article
CAS
PubMed
Google Scholar
Mokdad AH, Ford ES, Bowman BA, Nelson DE, Engelgau MM, Vinicor F, Marks JS: The continuing increase of diabetes in the US. Diabetes Care. 2001, 24: 412.
Article
CAS
PubMed
Google Scholar
Moore LL, Visioni AJ, Wilson PW, D'Agostino RB, Finkle WD, Ellison RC: Can sustained weight loss in overweight individuals reduce the risk of diabetes mellitus?. Epidemiology. 2000, 11: 269-273. 10.1097/00001648-200005000-00007.
Article
CAS
PubMed
Google Scholar
Reaven GM: Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988, 37: 1595-1607.
Article
CAS
PubMed
Google Scholar
Kaplan NM: The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med. 1989, 149: 1514-1520. 10.1001/archinte.149.7.1514.
Article
CAS
PubMed
Google Scholar
Groop LC: Insulin resistance: the fundamental trigger of type 2 diabetes. Diabetes Obes Metab. 1999, 1 (Suppl 1): S1-S7. 10.1046/j.1463-1326.1999.0010s1001.x.
Article
CAS
PubMed
Google Scholar
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001, 285: 2486-2497.
Auwerx J: PPARgamma, the ultimate thrifty gene. Diabetologia. 1999, 42: 1033-1049. 10.1007/s001250051268.
Article
CAS
PubMed
Google Scholar
Vamecq J, Latruffe N: Medical significance of peroxisome proliferator-activated receptors. Lancet. 1999, 354: 141-148. 10.1016/S0140-6736(98)10364-1.
Article
CAS
PubMed
Google Scholar
Hayden MR, Tyagi SC: Intimal redox stress: Accelerated atherosclerosis in metabolic syndrome and type 2 diabetes mellitus. Atheroscleropathy. Cardiovasc Diabetol. 2002, 1: 3-10.1186/1475-2840-1-3.
Article
PubMed Central
PubMed
Google Scholar
Porte D, Kahn SE: Beta-cell dysfunction and failure in type 2 diabetes: potential mechanisms. Diabetes. 2001, 50 (Suppl 1): S160-S163.
Article
CAS
PubMed
Google Scholar
National Heart Lung and Blood Institute: Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). Bethesda, Md: National Cholesterol Education Program (NCEP), National Institutes of Health;. 2001, [http://www.nhlbi.nih.gov/guidelines/cholesterol/atp3_rpt.htm]
Google Scholar
Guerre-Millo M, Rouault C, Poulain P, Andre J, Poitout V, Peters JM, Gonzalez FJ, Fruchart JC, Reach G, Staels B: PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance. Diabetes. 2001, 50: 2809-2814.
Article
CAS
PubMed
Google Scholar
Willson TM, Brown PJ, Sternbach DD, Henke BR: The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000, 43: 527-550. 10.1021/jm990554g.
Article
CAS
PubMed
Google Scholar
Berger J, Moller DE: The mechanisms of action of PPARs. Annu Rev Med. 2002, 53: 409-435. 10.1146/annurev.med.53.082901.104018.
Article
CAS
PubMed
Google Scholar
Vosper H, Khoudoli G, Graham T, Palmer C: Peroxisome proliferator-activated receptor agonists, hyperlipidaemia, and atherosclerosis. Pharmacol Ther. 2002, 95: 47-62. 10.1016/S0163-7258(02)00232-2.
Article
CAS
PubMed
Google Scholar
Fruchart JC, Staels B, Duriez P: The role of fibric acids in atherosclerosis. Curr Atheroscler Rep. 2001, 3: 83-92.
Article
CAS
PubMed
Google Scholar
Groop LC: Insulin resistance: the fundamental trigger of type 2 diabetes. Diab Obes Metab. 1999, 1 (Suppl 1): S1-7. 10.1046/j.1463-1326.1999.0010s1001.x.
Article
CAS
Google Scholar
Knowler WC, Barrett-Connor E, Fowler SE: Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002, 346: 393-403. 10.1056/NEJMoa012512.
Article
CAS
PubMed
Google Scholar
Pan XR, Li GW, Hu YH, Wang JX, Yang WY, An ZX, Hu ZX, Lin J, Xiao JZ, Cao HB: Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care. 1997, 20: 537-544.
Article
CAS
PubMed
Google Scholar
Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001, 344: 1343-1350. 10.1056/NEJM200105033441801.
Article
CAS
PubMed
Google Scholar
Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M: STOP-NIDDM Trail Research Group. Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet. 2002, 359: 2072-2077. 10.1016/S0140-6736(02)08905-5.
Article
CAS
PubMed
Google Scholar
Heymsfield SB, Segal KR, Hauptman J, Lucas CP, Boldrin MN, Rissanen A, Wilding JP, Sjostrom L: Effects of weight loss with orlistat on glucose tolerance and progression to type 2 diabetes in obese adults. Arch Intern Med. 2000, 160: 1321-1326. 10.1001/archinte.160.9.1321.
Article
CAS
PubMed
Google Scholar
Yusuf S, Gerstein H, Hoogwerf B, Pogue J, Bosch J, Wolffenbuttel BH, Zinman B: HOPE Study Investigators. Ramipril and the development of diabetes. JAMA. 2001, 286: 1882-1885. 10.1001/jama.286.15.1882.
Article
CAS
PubMed
Google Scholar