Figure 3

The atherogenesis tree, showing the complex interrelationship between hereditary and environmental factors in the pathogenesis of metabolic syndrome and atherothrombotic events. The central role of an insulin-resistant state following adipogenesis and nuclear peroxisome proliferator activated receptors (PPAR) deactivation is emphasized. CAD – coronary artery disease; AP – angina pectoris; ACS – acute coronary syndromes; CHF – congestive heart failure; PVD – peripheral vascular disease; HDL – high density lipoproteins cholesterol; IGT – impaired glucose tolerance; IFG – impaired fasting glucose.