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  1. Original investigation

    Obesity, metabolic syndrome and cardiovascular prognosis: from the Partners coronary computed tomography angiography registry

    To investigate the relationship among body mass index (BMI), cardiometabolic risk and coronary artery disease (CAD) among patients undergoing coronary computed tomography angiography (CTA).

    Edward A. Hulten, Marcio Sommer Bittencourt, Ryan Preston, Avinainder Singh, Carla Romagnolli, Brian Ghoshhajra, Ravi Shah, Siddique Abbasi, Suhny Abbara, Khurram Nasir, Michael Blaha, Udo Hoffmann, Marcelo F. Di Carli and Ron Blankstein

    Cardiovascular Diabetology 2017 16:14

    Published on: 25 January 2017

  2. Original investigation

    Skin autofluorescence is associated with inappropriate left ventricular mass and diastolic dysfunction in subjects at risk for cardiovascular disease

    Enhanced advanced glycation end products deposition within myocardial tissue may cause diastolic dysfunction. However, whether this is related to left ventricular hypertrophy or inappropriate left ventricular ...

    Chun-Cheng Wang, Yao-Chang Wang, Guei-Jane Wang, Ming-Yi Shen, Yen-Lin Chang, Show-Yih Liou, Hung-Chih Chen, An-Sheng Lee, Kuan-Cheng Chang, Wei-Yu Chen and Chiz-Tzung Chang

    Cardiovascular Diabetology 2017 16:15

    Published on: 25 January 2017

  3. Original investigation

    A randomised, active- and placebo-controlled, three-period crossover trial to investigate short-term effects of the dipeptidyl peptidase-4 inhibitor linagliptin on macro- and microvascular endothelial function in type 2 diabetes

    Studies of dipeptidyl peptidase (DPP)-4 inhibitors report heterogeneous effects on endothelial function in patients with type 2 diabetes (T2D). This study assessed the effects of the DPP-4 inhibitor linaglipti...

    Thomas Jax, Alin Stirban, Arne Terjung, Habib Esmaeili, Andreas Berk, Sandra Thiemann, Robert Chilton, Maximilian von Eynatten and Nikolaus Marx

    Cardiovascular Diabetology 2017 16:13

    Published on: 21 January 2017

  4. Original investigation

    T-cadherin deficiency increases vascular vulnerability in T2DM through impaired NO bioactivity

    Endothelial dysfunction plays a critical role in the development of type 2 diabetes (T2DM). T-cadherin (T-cad) has gained recognition as a regulator of endothelial cell (EC) function. The present study examine...

    Han Wang, Ling Tao, Anastasia Ambrosio, Wenjun Yan, Ross Summer, Wayne Bond Lau, Yajing Wang and Xinliang Ma

    Cardiovascular Diabetology 2017 16:12

    Published on: 19 January 2017

  5. Review

    The association between diabetes and dermal microvascular dysfunction non-invasively assessed by laser Doppler with local thermal hyperemia: a systematic review with meta-analysis

    Diabetes and cardiovascular disease develop in concert with metabolic abnormalities mirroring and causing changes in the vasculature, particularly the microcirculation. The microcirculation can be affected in ...

    Dagmar Fuchs, Pepijn P. Dupon, Laura A. Schaap and Richard Draijer

    Cardiovascular Diabetology 2017 16:11

    Published on: 19 January 2017

  6. Original investigation

    Diabetes does not impact the diagnostic performance of contrast-based fractional flow reserve: insights from the CONTRAST study

    Adenosine-free coronary pressure wire metrics have been proposed to test the functional significance of coronary artery lesions, but it is unexplored whether their diagnostic performance might be altered in pa...

    Giuseppe Gargiulo, Eugenio Stabile, Marco Ferrone, Emanuele Barbato, Frederik M. Zimmermann, Julien Adjedj, Barry Hennigan, Mitsuaki Matsumura, Nils P. Johnson, William F. Fearon, Allen Jeremias, Bruno Trimarco and Giovanni Esposito

    Cardiovascular Diabetology 2017 16:7

    Published on: 13 January 2017

  7. Review

    Differential effects of glucagon-like peptide-1 receptor agonists on heart rate

    While glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are known to increase heart rate (HR), it is insufficiently recognized that the extent varies greatly between the various agonists and is affected by...

    Martin Lorenz, Francesca Lawson, David Owens, Denis Raccah, Christine Roy-Duval, Anne Lehmann, Riccardo Perfetti and Lawrence Blonde

    Cardiovascular Diabetology 2017 16:6

    Published on: 13 January 2017

  8. Original investigation

    Sodium glucose transporter 2 (SGLT2) inhibition with empagliflozin improves cardiac diastolic function in a female rodent model of diabetes

    Obese and diabetic individuals are at increased risk for impairments in diastolic relaxation and heart failure with preserved ejection fraction. The impairments in diastolic relaxation are especially pronounce...

    Javad Habibi, Annayya R. Aroor, James R. Sowers, Guanghong Jia, Melvin R. Hayden, Mona Garro, Brady Barron, Eric Mayoux, R. Scott Rector, Adam Whaley-Connell and Vincent G. DeMarco

    Cardiovascular Diabetology 2017 16:9

    Published on: 13 January 2017

  9. Original investigation

    Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin

    The sodium-glucose co-transporter-2 (SGLT-2) inhibitors have been reported to increase both low-density lipoprotein (LDL) and high-density lipoprotein (HDL)-cholesterol (C). This study aimed to determine how S...

    Toshiyuki Hayashi, Tomoyasu Fukui, Noriko Nakanishi, Saki Yamamoto, Masako Tomoyasu, Anna Osamura, Makoto Ohara, Takeshi Yamamoto, Yasuki Ito and Tsutomu Hirano

    Cardiovascular Diabetology 2017 16:8

    Published on: 13 January 2017

  10. Original investigation

    Leptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitus

    Gestational diabetes mellitus (GDM) is a significant risk factor for cardiovascular disease (CVD) in later life, but the mechanism remains unclear. Adipokine imbalance in the presence of metabolic dysfunction ...

    Tove Lekva, Annika Elisabet Michelsen, Pål Aukrust, Tore Henriksen, Jens Bollerslev and Thor Ueland

    Cardiovascular Diabetology 2017 16:5

    Published on: 10 January 2017

  11. Original investigation

    Association of statin use and hypertriglyceridemia with diabetic macular edema in patients with type 2 diabetes and diabetic retinopathy

    To investigate the effects of dyslipidemia and statin therapy on progression of diabetic retinopathy and diabetic macular edema in patients with type 2 diabetes.

    Yoo-Ri Chung, Sung Wook Park, Shin-Young Choi, Seung Woo Kim, Ka Young Moon, Jeong Hun Kim and Kihwang Lee

    Cardiovascular Diabetology 2017 16:4

    Published on: 7 January 2017

  12. Original investigation

    Improved trends in cardiovascular complications among subjects with type 2 diabetes in Korea: a nationwide study (2006–2013)

    Representative data on the secular trends in cardiovascular disease (CVD) are limited in Asian populations with diabetes. We aimed to estimate the temporal trends in cardiovascular complications using Korean n...

    Chang Hee Jung, Jin Ook Chung, Kyungdo Han, Seung-Hyun Ko, Kyung Soo Ko and Joong-Yeol Park

    Cardiovascular Diabetology 2017 16:1

    Published on: 6 January 2017

  13. Review

    Blood pressure control in type 2 diabetic patients

    Diabetes mellitus (DM) and essential hypertension are common conditions that are frequently present together. Both are considered risk factors for cardiovascular disease and microvascular complications and the...

    Alon Grossman and Ehud Grossman

    Cardiovascular Diabetology 2017 16:3

    Published on: 6 January 2017

  14. Original investigation

    Arterial stiffness, endothelial and cognitive function in subjects with type 2 diabetes in accordance with absence or presence of diabetic foot syndrome

    Endothelial dysfunction is an early marker of cardiovascular disease so endothelial and arterial stiffness indexes are good indicators of vascular health. We aimed to assess whether the presence of diabetic fo...

    Antonino Tuttolomondo, Alessandra Casuccio, Giovanni Guercio, Carlo Maida, Alessandro Del Cuore, Domenico Di Raimondo, Irene Simonetta, Danilo Di Bona, Rosaria Pecoraro, Vittoriano Della Corte, Eliana Gulotta, Gaspare Gulotta and Antonio Pinto

    Cardiovascular Diabetology 2017 16:2

    Published on: 6 January 2017

  15. Original investigation

    Impact of obesity and epicardial fat on early left atrial dysfunction assessed by cardiac MRI strain analysis

    Diastolic dysfunction is a major cause of morbidity in obese individuals. We aimed to assess the ability of magnetic resonance imaging (MRI) derived left atrial (LA) strain to detect early diastolic dysfunctio...

    Morgane Evin, Kathryn M. Broadhouse, Fraser M. Callaghan, Rachel T. McGrath, Sarah Glastras, Rebecca Kozor, Samantha L. Hocking, Jérôme Lamy, Alban Redheuil, Nadjia Kachenoura, Greg R. Fulcher, Gemma A. Figtree and Stuart M. Grieve

    Cardiovascular Diabetology 2016 15:164

    Published on: 22 December 2016

  16. Original investigation

    Ankle-brachial index and incident diabetes mellitus: the atherosclerosis risk in communities (ARIC) study

    Individuals with peripheral artery disease (PAD) often have reduced physical activity, which may increase the future risk of diabetes mellitus. Although diabetes is a risk factor for PAD, whether low ankle-bra...

    Simin Hua, Laura R. Loehr, Hirofumi Tanaka, Gerardo Heiss, Josef Coresh, Elizabeth Selvin and Kunihiro Matsushita

    Cardiovascular Diabetology 2016 15:163

    Published on: 7 December 2016

  17. Original investigation

    Liraglutide improves metabolic parameters and carotid intima-media thickness in diabetic patients with the metabolic syndrome: an 18-month prospective study

    Liraglutide, a GLP-1 analogue, exerts several beneficial non-glycemic effects in patients with type-2 diabetes (T2DM), such as those on body weight, blood pressure, plasma lipids and inflammation markers. Howe...

    Manfredi Rizzo, Ali A. Rizvi, Angelo Maria Patti, Dragana Nikolic, Rosaria Vincenza Giglio, Giuseppa Castellino, Giovanni Li Volti, Massimiliano Caprio, Giuseppe Montalto, Vincenzo Provenzano, Stefano Genovese and Antonio Ceriello

    Cardiovascular Diabetology 2016 15:162

    Published on: 3 December 2016

  18. Original investigation

    Characteristics and outcomes of diabetic patients with an implantable cardioverter defibrillator in a real world setting: results from the Israeli ICD registry

    There are limited data regarding the effect of diabetes mellitus (DM) on the risks of both appropriate and inappropriate implantable cardioverter defibrillator (ICD) therapy. The present study was designed to ...

    Hillel Steiner, Michael Geist, Ilan Goldenberg, Mahmoud Suleiman, Michael Glikson, Alexander Tenenbaum, Moshe Swissa, Enrique Z. Fisman, Gregory Golovchiner, Boris Strasberg and Alon Barsheshet

    Cardiovascular Diabetology 2016 15:160

    Published on: 1 December 2016

  19. Original investigation

    Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis

    Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) is a major contributor to the development of atherosclerotic process. In a previous work, we demonstrated that the insulin receptor ...

    N. Beneit, C. E. Fernández-García, J. L. Martín-Ventura, L. Perdomo, Ó. Escribano, J. B. Michel, G. García-Gómez, S. Fernández, S. Díaz-Castroverde, J. Egido, A. Gómez-Hernández and M. Benito

    Cardiovascular Diabetology 2016 15:161

    Published on: 1 December 2016

  20. Original investigation

    Impact of visceral fat on gene expression profile in peripheral blood cells in obese Japanese subjects

    Visceral fat plays a central role in the development of metabolic syndrome and atherosclerotic cardiovascular diseases. The association of visceral fat accumulation with cardio-metabolic diseases has been repo...

    Yoshinari Obata, Norikazu Maeda, Yuya Yamada, Koji Yamamoto, Seiji Nakamura, Masaya Yamaoka, Yoshimitsu Tanaka, Shigeki Masuda, Hirofumi Nagao, Shiro Fukuda, Yuya Fujishima, Shunbun Kita, Hitoshi Nishizawa, Tohru Funahashi, Ken-ichi Matsubara, Yuji Matsuzawa…

    Cardiovascular Diabetology 2016 15:159

    Published on: 29 November 2016

  21. Review

    Relationship of cardiometabolic parameters in non-smokers, current smokers, and quitters in diabetes: a systematic review and meta-analysis

    Smoking is associated with increased macrovascular and microvascular complications in people with diabetes. In addition to other concomitant vascular perturbations, it also seems to influence the cardiometabol...

    Debasish Kar, Clare Gillies, Francesco Zaccardi, David Webb, Samuel Seidu, Solomon Tesfaye, Melanie Davies and Kamlesh Khunti

    Cardiovascular Diabetology 2016 15:158

    Published on: 24 November 2016

  22. Original investigation

    Empagliflozin lessened cardiac injury and reduced visceral adipocyte hypertrophy in prediabetic rats with metabolic syndrome

    The potential benefit of SGLT2 inhibitors in metabolic syndrome is with prediabetic stage unclear. This work was undertaken to investigate the non-glycemic effect of empagliflozin on metabolic syndrome rats wi...

    Hiroaki Kusaka, Nobutaka Koibuchi, Yu Hasegawa, Hisao Ogawa and Shokei Kim-Mitsuyama

    Cardiovascular Diabetology 2016 15:157

    Published on: 11 November 2016

  23. Original investigation

    Correlation between insulin-induced estrogen receptor methylation and atherosclerosis

    Hyperinsulinemia and insulin resistance have been recently recognized as an important cause of atherosclerosis. Clinical studies have also found that expression of the estrogen receptor is closely related to t...

    Jia Min, Zhong Weitian, Cai Peng, Peng Yan, Zhang Bo, Wang Yan, Bai Yun and Wang Xukai

    Cardiovascular Diabetology 2016 15:156

    Published on: 10 November 2016

  24. Original investigation

    Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels

    The leading cause of death among the obese population is heart failure and stroke prompted by structural and functional changes in the heart. The molecular mechanisms that underlie obesity-related cardiac remo...

    Elisa Lucas, Rocio Vila-Bedmar, Alba C. Arcones, Marta Cruces-Sande, Victoria Cachofeiro, Federico Mayor and Cristina Murga

    Cardiovascular Diabetology 2016 15:155

    Published on: 10 November 2016

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