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  1. Original article

    Association between metformin use and below-the-knee arterial calcification score in type 2 diabetic patients

    Vascular calcification (VC) is common in type 2 diabetes, and is associated with cardiovascular complications. Recent preclinical data suggest that metformin inhibits VC both in vitro and in animal models. How...

    Aurélien Mary, Agnes Hartemann, Sophie Liabeuf, Carole Elodie Aubert, Salim Kemel, Joe Elie Salem, Philippe Cluzel, Aurélie Lenglet, Ziad A. Massy, Jean-Daniel Lalau, Romuald Mentaverri, Olivier Bourron and Saïd Kamel

    Cardiovascular Diabetology 2017 16:24

    Published on: 15 February 2017

  2. Original investigation

    DPP-4 inhibition has no acute effect on BNP and its N-terminal pro-hormone measured by commercial immune-assays. A randomized cross-over trial in patients with type 2 diabetes

    Use of dipeptidyl peptidase-4 inhibitors (DPP4-i) for the treatment of type 2 diabetes (T2D) has been associated with a possible increase in the risk for heart failure (HF). B-type natriuretic peptide (BNP), w...

    Gian Paolo Fadini, Benedetta Maria Bonora, Mattia Albiero, Martina Zaninotto, Mario Plebani and Angelo Avogaro

    Cardiovascular Diabetology 2017 16:22

    Published on: 10 February 2017

  3. Original investigation

    Third generation drug eluting stent (DES) with biodegradable polymer in diabetic patients: 5 years follow-up

    To report the long-term safety and efficacy data of a third generation drug eluting stent (DES) with biodegradable polymer in the complex patient population of diabetes mellitus after a follow-up period of 5 ...

    Marcus Wiemer, Sinisa Stoikovic, Alexander Samol, Zisis Dimitriadis, Juan M. Ruiz-Nodar, Ralf Birkemeyer, Jacques Monsegu, Gérard Finet, David Hildick-Smith, Damras Tresukosol, Enrique Garcia Novo, Jacques J. Koolen, Emanuele Barbato and Gian Battista Danzi

    Cardiovascular Diabetology 2017 16:23

    Published on: 10 February 2017

  4. Original investigation

    Advanced glycation end products induce brain-derived neurotrophic factor release from human platelets through the Src-family kinase activation

    Brain-derived neurotrophic factor (BDNF) exerts beneficial effects not only on diabetic neuropathies but also on cardiovascular injury. There is argument regarding the levels of serum BDNF in patients with dia...

    Kazuo Furukawa, Ichiro Fuse, Yuriko Iwakura, Hidekazu Sotoyama, Osamu Hanyu, Hiroyuki Nawa, Hirohito Sone and Nobuyuki Takei

    Cardiovascular Diabetology 2017 16:20

    Published on: 8 February 2017

  5. Original investigation

    Obesity and type 2 diabetes have additive effects on left ventricular remodelling in normotensive patients-a cross sectional study

    It is unclear whether obesity and type 2 diabetes (T2D), either alone or in combination, induce left ventricular hypertrophy (LVH) independent of hypertension. In the current study, we provide clarity on this ...

    Kirstie A. De Jong, Juliane K. Czeczor, Smithamol Sithara, Kevin McEwen, Gary D. Loopaschuk, Alan Appelbe, Kimberly Cukier, Mark Kotowicz and Sean L. McGee

    Cardiovascular Diabetology 2017 16:21

    Published on: 8 February 2017

  6. Original investigation

    Inhibition of dynamin-related protein 1 protects against myocardial ischemia–reperfusion injury in diabetic mice

    Many cardioprotective pharmacological agents failed to exert their protective effects in diabetic hearts subjected to myocardial ischemia/reperfusion (MI/R). Identify the molecular basis linking diabetes with ...

    Mingge Ding, Qianqian Dong, Zhenghua Liu, Zheng Liu, Yinxian Qu, Xing Li, Cong Huo, Xin Jia, Feng Fu and Xiaoming Wang

    Cardiovascular Diabetology 2017 16:19

    Published on: 7 February 2017

  7. Original investigation

    Serum levels of interleukin-22, cardiometabolic risk factors and incident type 2 diabetes: KORA F4/FF4 study

    Interleukin-22 (IL-22) has beneficial effects on body weight, insulin resistance and inflammation in different mouse models, but its relevance for the development of type 2 diabetes in humans is unknown. We ai...

    Christian Herder, Julia M. Kannenberg, Maren Carstensen-Kirberg, Cornelia Huth, Christa Meisinger, Wolfgang Koenig, Annette Peters, Wolfgang Rathmann, Michael Roden and Barbara Thorand

    Cardiovascular Diabetology 2017 16:17

    Published on: 31 January 2017

  8. Original investigation

    The renal tubular damage marker urinary N-acetyl-β-d-glucosaminidase may be more closely associated with early detection of atherosclerosis than the glomerular damage marker albuminuria in patients with type 2 diabetes

    To determine the association between urinary N-acetyl-β-d-glucosaminidase (NAG), a marker of renal tubulopathy, and carotid intima-media thickness (IMT) and plaques in patients with type 2 diabetes mellitus (T2D)...

    So Ra Kim, Yong-ho Lee, Sang-Guk Lee, Eun Seok Kang, Bong-Soo Cha and Byung-Wan Lee

    Cardiovascular Diabetology 2017 16:16

    Published on: 26 January 2017

  9. Original investigation

    Obesity, metabolic syndrome and cardiovascular prognosis: from the Partners coronary computed tomography angiography registry

    To investigate the relationship among body mass index (BMI), cardiometabolic risk and coronary artery disease (CAD) among patients undergoing coronary computed tomography angiography (CTA).

    Edward A. Hulten, Marcio Sommer Bittencourt, Ryan Preston, Avinainder Singh, Carla Romagnolli, Brian Ghoshhajra, Ravi Shah, Siddique Abbasi, Suhny Abbara, Khurram Nasir, Michael Blaha, Udo Hoffmann, Marcelo F. Di Carli and Ron Blankstein

    Cardiovascular Diabetology 2017 16:14

    Published on: 25 January 2017

  10. Original investigation

    Skin autofluorescence is associated with inappropriate left ventricular mass and diastolic dysfunction in subjects at risk for cardiovascular disease

    Enhanced advanced glycation end products deposition within myocardial tissue may cause diastolic dysfunction. However, whether this is related to left ventricular hypertrophy or inappropriate left ventricular ...

    Chun-Cheng Wang, Yao-Chang Wang, Guei-Jane Wang, Ming-Yi Shen, Yen-Lin Chang, Show-Yih Liou, Hung-Chih Chen, An-Sheng Lee, Kuan-Cheng Chang, Wei-Yu Chen and Chiz-Tzung Chang

    Cardiovascular Diabetology 2017 16:15

    Published on: 25 January 2017

  11. Original investigation

    A randomised, active- and placebo-controlled, three-period crossover trial to investigate short-term effects of the dipeptidyl peptidase-4 inhibitor linagliptin on macro- and microvascular endothelial function in type 2 diabetes

    Studies of dipeptidyl peptidase (DPP)-4 inhibitors report heterogeneous effects on endothelial function in patients with type 2 diabetes (T2D). This study assessed the effects of the DPP-4 inhibitor linaglipti...

    Thomas Jax, Alin Stirban, Arne Terjung, Habib Esmaeili, Andreas Berk, Sandra Thiemann, Robert Chilton, Maximilian von Eynatten and Nikolaus Marx

    Cardiovascular Diabetology 2017 16:13

    Published on: 21 January 2017

  12. Original investigation

    T-cadherin deficiency increases vascular vulnerability in T2DM through impaired NO bioactivity

    Endothelial dysfunction plays a critical role in the development of type 2 diabetes (T2DM). T-cadherin (T-cad) has gained recognition as a regulator of endothelial cell (EC) function. The present study examine...

    Han Wang, Ling Tao, Anastasia Ambrosio, Wenjun Yan, Ross Summer, Wayne Bond Lau, Yajing Wang and Xinliang Ma

    Cardiovascular Diabetology 2017 16:12

    Published on: 19 January 2017

  13. Review

    The association between diabetes and dermal microvascular dysfunction non-invasively assessed by laser Doppler with local thermal hyperemia: a systematic review with meta-analysis

    Diabetes and cardiovascular disease develop in concert with metabolic abnormalities mirroring and causing changes in the vasculature, particularly the microcirculation. The microcirculation can be affected in ...

    Dagmar Fuchs, Pepijn P. Dupon, Laura A. Schaap and Richard Draijer

    Cardiovascular Diabetology 2017 16:11

    Published on: 19 January 2017

  14. Original investigation

    Diabetes does not impact the diagnostic performance of contrast-based fractional flow reserve: insights from the CONTRAST study

    Adenosine-free coronary pressure wire metrics have been proposed to test the functional significance of coronary artery lesions, but it is unexplored whether their diagnostic performance might be altered in pa...

    Giuseppe Gargiulo, Eugenio Stabile, Marco Ferrone, Emanuele Barbato, Frederik M. Zimmermann, Julien Adjedj, Barry Hennigan, Mitsuaki Matsumura, Nils P. Johnson, William F. Fearon, Allen Jeremias, Bruno Trimarco and Giovanni Esposito

    Cardiovascular Diabetology 2017 16:7

    Published on: 13 January 2017

  15. Review

    Differential effects of glucagon-like peptide-1 receptor agonists on heart rate

    While glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are known to increase heart rate (HR), it is insufficiently recognized that the extent varies greatly between the various agonists and is affected by...

    Martin Lorenz, Francesca Lawson, David Owens, Denis Raccah, Christine Roy-Duval, Anne Lehmann, Riccardo Perfetti and Lawrence Blonde

    Cardiovascular Diabetology 2017 16:6

    Published on: 13 January 2017

  16. Original investigation

    Sodium glucose transporter 2 (SGLT2) inhibition with empagliflozin improves cardiac diastolic function in a female rodent model of diabetes

    Obese and diabetic individuals are at increased risk for impairments in diastolic relaxation and heart failure with preserved ejection fraction. The impairments in diastolic relaxation are especially pronounce...

    Javad Habibi, Annayya R. Aroor, James R. Sowers, Guanghong Jia, Melvin R. Hayden, Mona Garro, Brady Barron, Eric Mayoux, R. Scott Rector, Adam Whaley-Connell and Vincent G. DeMarco

    Cardiovascular Diabetology 2017 16:9

    Published on: 13 January 2017

  17. Original investigation

    Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin

    The sodium-glucose co-transporter-2 (SGLT-2) inhibitors have been reported to increase both low-density lipoprotein (LDL) and high-density lipoprotein (HDL)-cholesterol (C). This study aimed to determine how S...

    Toshiyuki Hayashi, Tomoyasu Fukui, Noriko Nakanishi, Saki Yamamoto, Masako Tomoyasu, Anna Osamura, Makoto Ohara, Takeshi Yamamoto, Yasuki Ito and Tsutomu Hirano

    Cardiovascular Diabetology 2017 16:8

    Published on: 13 January 2017

  18. Original investigation

    Leptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitus

    Gestational diabetes mellitus (GDM) is a significant risk factor for cardiovascular disease (CVD) in later life, but the mechanism remains unclear. Adipokine imbalance in the presence of metabolic dysfunction ...

    Tove Lekva, Annika Elisabet Michelsen, Pål Aukrust, Tore Henriksen, Jens Bollerslev and Thor Ueland

    Cardiovascular Diabetology 2017 16:5

    Published on: 10 January 2017

  19. Original investigation

    Association of statin use and hypertriglyceridemia with diabetic macular edema in patients with type 2 diabetes and diabetic retinopathy

    To investigate the effects of dyslipidemia and statin therapy on progression of diabetic retinopathy and diabetic macular edema in patients with type 2 diabetes.

    Yoo-Ri Chung, Sung Wook Park, Shin-Young Choi, Seung Woo Kim, Ka Young Moon, Jeong Hun Kim and Kihwang Lee

    Cardiovascular Diabetology 2017 16:4

    Published on: 7 January 2017

  20. Original investigation

    Improved trends in cardiovascular complications among subjects with type 2 diabetes in Korea: a nationwide study (2006–2013)

    Representative data on the secular trends in cardiovascular disease (CVD) are limited in Asian populations with diabetes. We aimed to estimate the temporal trends in cardiovascular complications using Korean n...

    Chang Hee Jung, Jin Ook Chung, Kyungdo Han, Seung-Hyun Ko, Kyung Soo Ko and Joong-Yeol Park

    Cardiovascular Diabetology 2017 16:1

    Published on: 6 January 2017

  21. Review

    Blood pressure control in type 2 diabetic patients

    Diabetes mellitus (DM) and essential hypertension are common conditions that are frequently present together. Both are considered risk factors for cardiovascular disease and microvascular complications and the...

    Alon Grossman and Ehud Grossman

    Cardiovascular Diabetology 2017 16:3

    Published on: 6 January 2017

  22. Original investigation

    Arterial stiffness, endothelial and cognitive function in subjects with type 2 diabetes in accordance with absence or presence of diabetic foot syndrome

    Endothelial dysfunction is an early marker of cardiovascular disease so endothelial and arterial stiffness indexes are good indicators of vascular health. We aimed to assess whether the presence of diabetic fo...

    Antonino Tuttolomondo, Alessandra Casuccio, Giovanni Guercio, Carlo Maida, Alessandro Del Cuore, Domenico Di Raimondo, Irene Simonetta, Danilo Di Bona, Rosaria Pecoraro, Vittoriano Della Corte, Eliana Gulotta, Gaspare Gulotta and Antonio Pinto

    Cardiovascular Diabetology 2017 16:2

    Published on: 6 January 2017

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