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  1. Original investigation

    Remote ischemic preconditioning differentially attenuates post-ischemic cardiac arrhythmia in streptozotocin-induced diabetic versus nondiabetic rats

    Sudden cardiac death (SCD), a leading cause of global mortality, most commonly arises from a substrate of cardiac ischemia, but requires an additional trigger. Diabetes mellitus (DM) predisposes to SCD even af...

    Zhaoyang Hu, Mou Chen, Ping Zhang, Jin Liu and Geoffrey W. Abbott

    Cardiovascular Diabetology 2017 16:57

    Published on: 26 April 2017

  2. Original investigation

    Anatomic fat depots and cardiovascular risk: a focus on the leg fat using nationwide surveys (KNHANES 2008–2011)

    Although central fat is a well-known risk factor for cardiovascular disease (CVD) and cardiometabolic disorders, the effect of other regional fats or muscle distribution on CVD risk has not been fully investig...

    Eugene Han, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, In-Kyu Lee and Bong-Soo Cha

    Cardiovascular Diabetology 2017 16:54

    Published on: 26 April 2017

  3. Original investigation

    Plasma matrix metalloproteinases are associated with incident cardiovascular disease and all-cause mortality in patients with type 1 diabetes: a 12-year follow-up study

    Altered regulation of extracellular matrix remodeling by matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) may contribute to vascular complications in type 1 diabetes. We invest...

    S. A. Peeters, L. Engelen, J. Buijs, A. Jorsal, H.-H. Parving, L. Tarnow, P. Rossing, C. G. Schalkwijk and C. D. A. Stehouwer

    Cardiovascular Diabetology 2017 16:55

    Published on: 26 April 2017

  4. Original investigation

    Advanced glycation end-products decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells

    Advanced glycation end-products (AGEs) are elevated under diabetic conditions and associated with insulin resistance, endothelial dysfunction and vascular inflammation in humans. It has been demonstrated that ...

    Xiaomei Ren, Liqun Ren, Qin Wei, Hua Shao, Long Chen and Naifeng Liu

    Cardiovascular Diabetology 2017 16:52

    Published on: 20 April 2017

  5. Original investigation

    Treatment with high-dose n-3 PUFAs has no effect on platelet function, coagulation, metabolic status or inflammation in patients with atherosclerosis and type 2 diabetes

    Despite numerous studies on cardioprotective effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs), there is limited evidence for n-3 PUFA-mediated effects, especially at its higher dose, on cardiovascula...

    Malgorzata Poreba, Magdalena Mostowik, Aleksander Siniarski, Renata Golebiowska-Wiatrak, Krzysztof Piotr Malinowski, Maciej Haberka, Ewa Konduracka, Jadwiga Nessler, Anetta Undas and Grzegorz Gajos

    Cardiovascular Diabetology 2017 16:50

    Published on: 14 April 2017

  6. Original investigation

    Subclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus: a hospital-based cohort study

    Gestational diabetes mellitus (GDM) has significant implications for the future health of the mother. Some clinical studies have suggested subclinical inflammation and vascular dysfunction after GDM. We aimed ...

    Tiina Vilmi-Kerälä, Anneli Lauhio, Taina Tervahartiala, Outi Palomäki, Jukka Uotila, Timo Sorsa and Ari Palomäki

    Cardiovascular Diabetology 2017 16:49

    Published on: 13 April 2017

  7. Study protocol

    Rationale and design of a multicenter placebo-controlled double-blind randomized trial to evaluate the effect of empagliflozin on endothelial function: the EMBLEM trial

    Type 2 diabetes mellitus (T2DM) is characterized by systemic metabolic abnormalities and the development of micro- and macrovascular complications, resulting in a shortened life expectancy. A recent cardiovasc...

    Atsushi Tanaka, Michio Shimabukuro, Yosuke Okada, Isao Taguchi, Minako Yamaoka-Tojo, Hirofumi Tomiyama, Hiroki Teragawa, Seigo Sugiyama, Hisako Yoshida, Yasunori Sato, Atsushi Kawaguchi, Yumi Ikehara, Noritaka Machii, Tatsuya Maruhashi, Kosuke R. Shima, Toshinari Takamura…

    Cardiovascular Diabetology 2017 16:48

    Published on: 12 April 2017

  8. Original investigation

    Metformin and sulodexide restore cardiac microvascular perfusion capacity in diet-induced obese rats

    Disturbances in coronary microcirculatory function, such as the endothelial glycocalyx, are early hallmarks in the development of obesity and insulin resistance. Accordingly, in the present study myocardial mi...

    Judith van Haare, M. Eline Kooi, Jurgen W. G. E. van Teeffelen, Hans Vink, Jos Slenter, Hanneke Cobelens, Gustav J. Strijkers, Dennis Koehn, Mark J. Post and Marc van Bilsen

    Cardiovascular Diabetology 2017 16:47

    Published on: 11 April 2017

  9. Original investigation

    Human serum RNase-L level is inversely associated with metabolic syndrome and age

    Ribonuclease-L (RNase-L) was known to be a ubiquitous enzyme involved in several cellular functions, especially innate immunity. It was recently shown to participate in adipogenesis in rodents. Here, we develo...

    Yi-Ting Wang, Ping-Huei Tseng, Chi-Ling Chen, Der-Sheng Han, Yu-Chiao Chi, Fen-Yu Tseng and Wei-Shiung Yang

    Cardiovascular Diabetology 2017 16:46

    Published on: 11 April 2017

  10. Original investigation

    Pregnancy-associated plasma protein-A is a stronger predictor for adverse cardiovascular outcomes after acute coronary syndrome in type-2 diabetes mellitus

    The risk prediction of pregnancy-associated plasma protein-A (PAPP-A) for future cardiovascular (CV) events post acute coronary syndrome (ACS) in patients with type-2 diabetes mellitus (T2DM) was investigated ...

    Wei-Ping Li, Moni B. Neradilek, Fu-Sheng Gu, Daniel A. Isquith, Zhi-Jun Sun, Xing Wu, Hong-Wei Li and Xue-Qiao Zhao

    Cardiovascular Diabetology 2017 16:45

    Published on: 5 April 2017

  11. Original investigation

    Glycemia and the cardioprotective effects of insulin pre-conditioning in the isolated rat heart

    While acute hyperglycemia has been shown to mitigate the beneficial effects of ischemic preconditioning, its effect on insulin-induced preconditioning remains unclear.

    Yosuke Nakadate, Hiroaki Sato, Takeshi Oguchi, Tamaki Sato, Akiko Kawakami, Tadahiko Ishiyama, Takashi Matsukawa and Thomas Schricker

    Cardiovascular Diabetology 2017 16:43

    Published on: 4 April 2017

  12. Review

    Regulation of visceral and epicardial adipose tissue for preventing cardiovascular injuries associated to obesity and diabetes

    Nowadays, obesity is seriously increasing in most of the populations all over the world, and is associated with the development and progression of high-mortality diseases such as type-2 diabetes mellitus (T2DM) a...

    N. González, Z. Moreno-Villegas, A. González-Bris, J. Egido and Ó. Lorenzo

    Cardiovascular Diabetology 2017 16:44

    Published on: 4 April 2017

  13. Original investigation

    Effects of the SGLT2 inhibitor dapagliflozin on HDL cholesterol, particle size, and cholesterol efflux capacity in patients with type 2 diabetes: a randomized placebo-controlled trial

    Sodium-glucose co-transporter-2 inhibitors (SGLT2i) reduce glucose levels, body weight, and blood pressure, possibly resulting in cardiovascular protection. In phase III trials, SGLT2i were shown to increase H...

    Gian Paolo Fadini, Benedetta Maria Bonora, Giancarlo Zatti, Nicola Vitturi, Elisabetta Iori, Maria Cristina Marescotti, Mattia Albiero and Angelo Avogaro

    Cardiovascular Diabetology 2017 16:42

    Published on: 4 April 2017

  14. Original investigation

    Efficacy and safety of canagliflozin in patients with type 2 diabetes based on history of cardiovascular disease or cardiovascular risk factors: a post hoc analysis of pooled data

    Treatment of patients with type 2 diabetes mellitus (T2DM) and a history of cardiovascular (CV) disease or CV risk factors may present clinical challenges due to the presence of comorbid conditions and the use...

    Michael J. Davies, Katherine Merton, Ujjwala Vijapurkar, Jacqueline Yee and Rong Qiu

    Cardiovascular Diabetology 2017 16:40

    Published on: 21 March 2017

  15. Original investigation

    Lipoprotein(a) and incident type-2 diabetes: results from the prospective Bruneck study and a meta-analysis of published literature

    We aimed to (1) assess the association between lipoprotein(a) [Lp(a)] concentration and incident type-2 diabetes in the Bruneck study, a prospective population-based study, and (2) combine findings with eviden...

    Ellie Paige, Katya L. Masconi, Sotirios Tsimikas, Florian Kronenberg, Peter Santer, Siegfried Weger, Johann Willeit, Stefan Kiechl and Peter Willeit

    Cardiovascular Diabetology 2017 16:38

    Published on: 21 March 2017

  16. Original investigation

    Association between obstructive sleep apnea severity and endothelial dysfunction in patients with type 2 diabetes

    Obstructive sleep apnea (OSA) and type 2 diabetes (T2D) are associated with endothelial dysfunction a main predictor of late cardiovascular (CV) events. Despite the high prevalence of OSA in patients with T2D,...

    Vanessa Bironneau, François Goupil, Pierre Henri Ducluzeau, Marc Le Vaillant, Pierre Abraham, Samir Henni, Séverine Dubois, Audrey Paris, Pascaline Priou, Nicole Meslier, Claire Sanguin, Wojciech Trzépizur, Ramaroson Andriantsitohaina, Maria Carmen Martinez and Frédéric Gagnadoux

    Cardiovascular Diabetology 2017 16:39

    Published on: 21 March 2017

  17. Original investigation

    Subclinical left ventricular diastolic dysfunction and incident type 2 diabetes risk: the Korean Genome and Epidemiology Study

    Subclinical left ventricular (LV) diastolic dysfunction in type 2 diabetes (T2D) is a common finding and represents an early sign of diabetic cardiomyopathy. However, the relationship between LV diastolic dysf...

    Juri Park, Jin-Seok Kim, Seong Hwan Kim, Sunwon Kim, Sang Yup Lim, Hong-Euy Lim, Goo-Yeong Cho, Ki-Chul Sung, Jang-Young Kim, Inkyung Baik, Kwang Kon Koh, Jung Bok Lee, Seung Ku Lee and Chol Shin

    Cardiovascular Diabetology 2017 16:36

    Published on: 14 March 2017

  18. Commentary

    Report from the 2nd Cardiovascular Outcome Trial (CVOT) Summit of the Diabetes and Cardiovascular Disease (D&CVD) EASD Study Group

    The 2nd Cardiovascular Outcome Trial (CVOT) Summit of the Diabetes and Cardiovascular Disease (D&CVD) EASD Study Group was held on the 20th–21st October 2016 in Munich. This second Summit was organized in ligh...

    Oliver Schnell, Eberhard Standl, Doina Catrinoiu, Stefano Genovese, Nebojsa Lalic, Jan Skra, Paul Valensi, Dario Rahelic and Antonio Ceriello

    Cardiovascular Diabetology 2017 16:35

    Published on: 11 March 2017

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