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  1. Bempedoic acid is an oral, once-daily, first-in-class drug being developed for the treatment of hyperlipidemia. However, evidence of bempedoic acid use for the prevention of cardiovascular events and diabetes ...

    Authors: Xing Wang, Yu Zhang, Huiwen Tan, Peng Wang, Xi Zha, Weelic Chong, Liangxue Zhou and Fang Fang
    Citation: Cardiovascular Diabetology 2020 19:128
    Content type: Original investigation Published on:

  2. The role of omega-3 polyunsaturated fatty acids (n-3PUFA), and the potential impact of n-3PUFA supplementation, in the treatment and management of type 1 diabetes (T1D) remains unclear and controversial. There...

    Authors: Lauren L. O’Mahoney, Gareth Dunseath, Rachel Churm, Mel Holmes, Christine Boesch, Antonios Stavropoulos-Kalinoglou, Ramzi A. Ajjan, Karen M. Birch, Nicolas M. Orsi, Georgia Mappa, Oliver J. Price and Matthew D. Campbell
    Citation: Cardiovascular Diabetology 2020 19:127
    Content type: Original investigation Published on:

  3. Lipoprotein disturbances have been associated with increased cardiovascular disease (CVD) risk in type 1 diabetes mellitus (T1DM). We assessed the advanced lipoprotein profile in T1DM individuals, and analysed...

    Authors: Antonio J. Amor, Esmeralda Castelblanco, Marta Hernández, Marga Gimenez, Minerva Granado-Casas, Jesús Blanco, Berta Soldevila, Enric Esmatjes, Ignacio Conget, Nuria Alonso, Emilio Ortega and Didac Mauricio
    Citation: Cardiovascular Diabetology 2020 19:126
    Content type: Original investigation Published on:

  4. Adiponectin plays role in multiple metabolic pathways. Previous studies in cardiovascular disease evaluated the association between adiponectin and clinical outcomes, yielding conflicting results. The aim of t...

    Authors: Wen-Jun Tu, Han-Cheng Qiu, Ya-Kun Liu, Qiang Liu, Xianwei Zeng and Jizong Zhao
    Citation: Cardiovascular Diabetology 2020 19:125
    Content type: Original investigation Published on:

  5. Observational series suggest a mortality benefit from metformin in the heart failure (HF) population. However, the benefit of metformin in HF with preserved ejection fraction (HFpEF) has yet to be explored. We...

    Authors: Amera Halabi, Jonathan Sen, Quan Huynh and Thomas H. Marwick
    Citation: Cardiovascular Diabetology 2020 19:124
    Content type: Original investigation Published on:

  6. Ferritin, a crucial element for iron homeostasis, is associated with chronic diseases characterized by subclinical inflammation such as essential arterial hypertension and type 2 diabetes mellitus (T2DM), show...

    Authors: Angela Sciacqua, Ettore Ventura, Giovanni Tripepi, Velia Cassano, Graziella D’Arrigo, Stefanos Roumeliotis, Raffale Maio, Sofia Miceli, Maria Perticone, Francesco Andreozzi, Giorgio Sesti and Francesco Perticone
    Citation: Cardiovascular Diabetology 2020 19:123
    Content type: Original investigation Published on:

  7. Studies suggest that cardio-vascular risk factors could foster the development of type 2 diabetes (T2D). This could partly be mediated by pancreatic atherosclerosis resulting in pancreatic ischemia. We hypothe...

    Authors: Laure Alexandre-Heymann, Matthias Barral, Anthony Dohan and Etienne Larger
    Citation: Cardiovascular Diabetology 2020 19:122
    Content type: Original investigation Published on:

  8. Angiopoietin-like protein 8 (ANGPTL8), an important regulator of lipid metabolism, is increased in diabetes and is associated with insulin resistance. However, the role of ANGPTL8 in the outcomes of diabetic p...

    Authors: Huajie Zou, Yongping Xu, Xi Chen, Ping Yin, Danpei Li, Wenjun Li, Junhui Xie, Shiying Shao, Liegang Liu and Xuefeng Yu
    Citation: Cardiovascular Diabetology 2020 19:121
    Content type: Original investigation Published on:

  9. Growth differentiation factor-15 (GDF-15) is a marker of inflammation, oxidative stress and it is associated with adverse prognosis in cardiovascular disease. The aim of the present cohort study is to investig...

    Authors: Man Li, Lei Duan, Yu-Lun Cai, Hui-Ying Li, Ben-Chuan Hao, Jian-Qiao Chen and Hong-Bin Liu
    Citation: Cardiovascular Diabetology 2020 19:120
    Content type: Original investigation Published on:

  10. Diabetes mellitus is one of the risk factors for coronary artery disease and frequently associated with multivessels disease and poor clinical outcomes. Long term outcome of successful revascularization of chr...

    Authors: Chuan-Tsai Tsai, Wei-Chieh Huang, Hsin-I Teng, Yi-Lin Tsai and Tse-Min Lu
    Citation: Cardiovascular Diabetology 2020 19:119
    Content type: Original investigation Published on:

  11. Obesity, especially abdominal obesity, has been considered a risk factor for diabetic complications. Many abdominal obesity indices have been established, including neck circumference (NC), waist-to-hip ratio ...

    Authors: Heng Wan, Yuying Wang, Qian Xiang, Sijie Fang, Yi Chen, Chi Chen, Wen Zhang, Haojie Zhang, Fangzhen Xia, Ningjian Wang and Yingli Lu
    Citation: Cardiovascular Diabetology 2020 19:118
    Content type: Original investigation Published on:

  12. Previous publications about the association between fatty-acid binding protein 4 (FABP4) and cardiac remodeling have reported different, both beneficial and harmful, associations. Aim of the present investigat...

    Authors: Beatrice von Jeinsen, Lisa Ritzen, Julia Vietheer, Claudia Unbehaun, Maren Weferling, Christoph Liebetrau, Christian W. Hamm, Andreas Rolf and Till Keller
    Citation: Cardiovascular Diabetology 2020 19:117
    Content type: Original investigation Published on:

  13. Previous studies have investigated the relationship of the triglyceride glucose (TyG) index with the incidence of cardiovascular events. However, to date, there have been no studies comparing the predictive va...

    Authors: Chengping Hu, Jianwei Zhang, Jinxing Liu, Yan Liu, Ang Gao, Yong Zhu and Yingxin Zhao
    Citation: Cardiovascular Diabetology 2020 19:116
    Content type: Original investigation Published on:

  14. The coronavirus disease 2019 (COVID-19) has been declared as pandemic by the World Health Organization and is causing substantial morbidity and mortality all over the world. Type 2 diabetes, hypertension, and ...

    Authors: Miriam Longo, Paola Caruso, Maria Ida Maiorino, Giuseppe Bellastella, Dario Giugliano and Katherine Esposito
    Citation: Cardiovascular Diabetology 2020 19:115
    Content type: Commentary Published on:

  15. In the pandemic “Corona Virus Disease 2019” (COVID-19) people with diabetes have a high risk to require ICU admission. The management of diabetes in Intensive Care Unit is always challenging, however, when dia...

    Authors: Antonio Ceriello, Eberhard Standl, Doina Catrinoiu, Baruch Itzhak, Nebojsa M. Lalic, Dario Rahelic, Oliver Schnell, Jan Škrha and Paul Valensi
    Citation: Cardiovascular Diabetology 2020 19:114
    Content type: Review Published on:

  16. The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using s...

    Authors: Ki-Bum Won, Byoung Kwon Lee, Hyung-Bok Park, Ran Heo, Sang-Eun Lee, Asim Rizvi, Fay Y. Lin, Amit Kumar, Martin Hadamitzky, Yong-Jin Kim, Ji Min Sung, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J. Budoff, Ilan Gottlieb…
    Citation: Cardiovascular Diabetology 2020 19:113
    Content type: Original investigation Published on:

  17. Both lipid and glucose abnormalities are associated with hypertension (HTN). However, it is unclear whether the triglyceride-glucose (TyG) index is associated with HTN. Therefore the aim of this study is to in...

    Authors: Binruo Zhu, Jie Wang, Kang Chen, Wenhua Yan, Anping Wang, Weiqing Wang, Zhengnan Gao, Xulei Tang, Li Yan, Qin Wan, Zuojie Luo, Guijun Qin, Lulu Chen and Yiming Mu
    Citation: Cardiovascular Diabetology 2020 19:112
    Content type: Original investigation Published on:

  18. Merging studies have reported the association of lipoprotein(a) [Lp(a)] with poor outcomes of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). However, the prognostic importance ...

    Authors: Yan Zhang, Jing-Lu Jin, Ye-Xuan Cao, Hui-Wen Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Ying Gao, Qi Hua, Yan-Fang Li, Rui-Xia Xu and Jian-Jun Li
    Citation: Cardiovascular Diabetology 2020 19:111
    Content type: Original investigation Published on:

  19. This study aimed to investigate the preventive effects of tofogliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, on atherosclerosis progression in type 2 diabetes (T2DM) patients without ...

    Authors: Naoto Katakami, Tomoya Mita, Hidenori Yoshii, Toshihiko Shiraiwa, Tetsuyuki Yasuda, Yosuke Okada, Keiichi Torimoto, Yutaka Umayahara, Hideaki Kaneto, Takeshi Osonoi, Tsunehiko Yamamoto, Nobuichi Kuribayashi, Kazuhisa Maeda, Hiroki Yokoyama, Keisuke Kosugi, Kentaro Ohtoshi…
    Citation: Cardiovascular Diabetology 2020 19:110
    Content type: Original investigation Published on:

  20. Plaque rupture (PR) and plaque erosion (PE) are main causes of acute myocardial infarction with different demographic and histology characteristics and need different treatment strategy. PR and PE can be ident...

    Authors: Jinxin Liu, Shanjie Wang, Can Cui, Hengxuan Cai, Rong Sun, Weili Pan, Shaohong Fang and Bo Yu
    Citation: Cardiovascular Diabetology 2020 19:109
    Content type: Original investigation Published on:

  21. The relationship between triglyceride-glucose index (TyG index) and the prevalence and prognosis of cardiovascular disease has been confirmed by former studies. However, it remains uncertain whether TyG index ...

    Authors: Qi Zhao, Ting-Yu Zhang, Yu-Jing Cheng, Yue Ma, Ying-Kai Xu, Jia-Qi Yang and Yu-Jie Zhou
    Citation: Cardiovascular Diabetology 2020 19:108
    Content type: Original investigation Published on:

  22. In randomised clinical trials, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium–glucose cotransporter 2 (SGLT-2) inhibitors reduced cardiovascular events in patients with type 2 diabetes (T2D) ...

    Authors: David Thein, Mia Nielsen Christiansen, Ulrik Madvig Mogensen, Johan Skov Bundgaard, Rasmus Rørth, Christian Madelaire, Emil Loldrup Fosbøl, Morten Schou, Christian Torp-Pedersen, Gunnar Gislason, Lars Køber and Søren Lund Kristensen
    Citation: Cardiovascular Diabetology 2020 19:107
    Content type: Original investigation Published on:

  24. To assess the associations of various HbA1c measures, including a single baseline HbA1c value, overall mean, yearly updated means, standard deviation (HbA1c-SD), coefficient of variation (HbA1c-CV), and HbA1c ...

    Authors: Chen-Yi Yang, Pei-Fang Su, Jo-Ying Hung, Huang-Tz Ou and Shihchen Kuo
    Citation: Cardiovascular Diabetology 2020 19:105
    Content type: Original investigation Published on:

  25. The atherogenicity of remnant cholesterol (RC) has been underlined by recent guidelines, which was linked to coronary artery disease (CAD), especially for patients with diabetes mellitus (DM). This study aimed...

    Authors: Ye-Xuan Cao, Hui-Wen Zhang, Jing-Lu Jin, Hui-Hui Liu, Yan Zhang, Ying Gao, Yuan-Lin Guo, Na-Qiong Wu, Qi Hua, Yan-Fang Li, Xiao-Lin Li, Rui-Xia Xu, Chuan-Jue Cui, Geng Liu, Qian Dong, Jing Sun…
    Citation: Cardiovascular Diabetology 2020 19:104
    Content type: Original investigation Published on:

  26. Both diabetes and obesity are risk factors for perioperative major adverse events. This study aims to evaluate the association between prior bariatric surgery (prior-BS) and perioperative cardiovascular outcom...

    Authors: Jiewen Jin, Zhantao Deng, Lijuan Xu, Hai Li, Pengyuan Zhang, Liehua Liu, Juan Liu, Hedong Han, Zhimin Huang, Xiaopei Cao, Haipeng Xiao and Yanbing Li
    Citation: Cardiovascular Diabetology 2020 19:103
    Content type: Original investigation Published on:

  28. Left ventricular systolic dysfunction (LVSD) occurs frequently after acute ST-segment elevation myocardial infarction (STEMI). The predisposing factors and underlying mechanism of post-infarct LVSD are not ful...

    Authors: Yong Zhu, Kesen Liu, Shuai Meng, Ruofei Jia, Xuan Lei, Maolin Chen, Kaiyuan Zou, Huagang Zhu and Zening Jin
    Citation: Cardiovascular Diabetology 2020 19:101
    Content type: Original investigation Published on:

  29. In this study, we compared the outcomes of medical therapy (MT) with successful percutaneous coronary intervention (PCI) in chronic total occlusions (CTO) patients with and without type 2 diabetes mellitus.

    Authors: Lei Guo, Junjie Wang, Huaiyu Ding, Shaoke Meng, Xiaoyan Zhang, Haichen Lv, Lei Zhong, Jian Wu, Jiaying Xu, Xuchen Zhou and Rongchong Huang
    Citation: Cardiovascular Diabetology 2020 19:100
    Content type: Original investigation Published on:

    The Correction to this article has been published in Cardiovascular Diabetology 2021 20:31

  30. Physical inactivity (PI) is associated with the development of non-communicable chronic diseases. The purposes of this study were to estimate the extent to which the 31% relative increase in PI among 35–64 yea...

    Authors: Catalina Medina, Pamela Coxson, Joanne Penko, Ian Janssen, Sergio Bautista-Arredondo, Simón Barquera and Kirsten Bibbins-Domingo
    Citation: Cardiovascular Diabetology 2020 19:99
    Content type: Original investigation Published on:

  31. Sodium/glucose cotransporter-2 inhibitors (SGLT2i) are a new type of glucose-lowering drug that can reduce blood glucose by inhibiting its reabsorption in proximal tubules and by promoting urinary glucose excr...

    Authors: Lihua Ni, Cheng Yuan, Guopeng Chen, Changjiang Zhang and Xiaoyan Wu
    Citation: Cardiovascular Diabetology 2020 19:98
    Content type: Review Published on:

  32. The influence of intensive glucose control in diabetic patients on the macrovascular outcomes is controversial. Thus, this study aimed to elucidate the effect of preprocedural hemoglobin A1c (HbA1c) on clinica...

    Authors: Jung-Joon Cha, Hyoeun Kim, Young-Guk Ko, Donghoon Choi, Jae-Hwan Lee, Chang-Hwan Yoon, In-Ho Chae, Cheol Woong Yu, Seung Whan Lee, Sang-Rok Lee, Seung Hyuk Choi, Yoon Seok Koh and Pil-Ki Min
    Citation: Cardiovascular Diabetology 2020 19:97
    Content type: Original investigation Published on:

  33. The cardiovascular outcome trials (CVOTs) have shown that glucagon like peptide-1 receptor agonists (GLP1RAs) have varying degrees of cardiovascular (CV) safety in patients with type 2 diabetes mellitus (T2DM....

    Authors: Osamah M. Alfayez, Omar A. Almohammed, Omar S. Alkhezi, Abdulaali R. Almutairi and Majed S. Al Yami
    Citation: Cardiovascular Diabetology 2020 19:96
    Content type: Original investigation Published on:

  34. Dapagliflozin is one of the novel glucose-lowering agents, which has recently been reported to reduce the risk of hospitalization for heart failure (hHF). The present study aimed to compare the differences bet...

    Authors: Jong-Mi Seong, Jong Joo Kim, Hae Jin Kim and Hyun Soon Sohn
    Citation: Cardiovascular Diabetology 2020 19:95
    Content type: Original investigation Published on:

  35. Studies assessing the efficacy of pioglitazone solely for primary stroke prevention in Asian patients with type 2 diabetes mellitus (DM) and present multiple cardiovascular (CV) risk factors are rare. Thus, we...

    Authors: Yi-Chih Hung, Lu-Ting Chiu, Hung-Yu Huang and Da-Tian Bau
    Citation: Cardiovascular Diabetology 2020 19:94
    Content type: Original investigation Published on:

  36. The potential for PPAR agonists to positively affect risk of cardiovascular disease in patients with type 2 diabetes (T2DM) is of persistent attention. The PRESS XII study primarily aimed to evaluate the effic...

    Authors: Manjunath Krishnappa, Kishor Patil, Krupi Parmar, Purav Trivedi, Nirali Mody, Chintan Shah, Khushboo Faldu, Sanjay Maroo and Deven Parmar
    Citation: Cardiovascular Diabetology 2020 19:93
    Content type: Original investigation Published on:

  37. Accumulation of advanced glycation end products (AGEs) leads to chronic glycation of proteins and tissue damage, particularly in patients with diabetes mellitus (DM). We aimed to evaluate whether increased acc...

    Authors: Magdalena Kopytek, Michał Ząbczyk, Piotr Mazur, Anetta Undas and Joanna Natorska
    Citation: Cardiovascular Diabetology 2020 19:92
    Content type: Original investigation Published on:

  38. A sodium-glucose co-transporter 2 (SGLT-2) inhibitor had favorable impact on the attenuation of hyperglycemia together with the severity of heart failure. However, the effects of acute dapagliflozin administra...

    Authors: Charshawn Lahnwong, Siripong Palee, Nattayaporn Apaijai, Sirawit Sriwichaiin, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Siriporn C. Chattipakorn and Nipon Chattipakorn
    Citation: Cardiovascular Diabetology 2020 19:91
    Content type: Original investigation Published on:

  39. Exercise induced albuminuria (EiA) is elevated in patients with metabolic dysfunction and diabetes, and may serve as an early biomarker for endothelial dysfunction and “kidney reserve”. However, the change in ...

    Authors: Rafael Y. Brzezinski, Limor Friedensohn, Itzhak Shapira, David Zeltser, Ori Rogowski, Shlomo Berliner, Ayelet Grupper and Shani Shenhar-Tsarfaty
    Citation: Cardiovascular Diabetology 2020 19:90
    Content type: Original investigation Published on:

  40. Fatty acid-binding protein 4 (FABP4) acts as a novel adipokine, and elevated FABP4 concentration is associated with obesity, insulin resistance and atherosclerosis. Dipeptidyl peptidase-4 (DPP-4) inhibitors, a...

    Authors: Masato Furuhashi, Ichiro Sakuma, Takeshi Morimoto, Yukimura Higashiura, Akiko Sakai, Megumi Matsumoto, Mio Sakuma, Michio Shimabukuro, Takashi Nomiyama, Osamu Arasaki, Koichi Node and Shinichiro Ueda
    Citation: Cardiovascular Diabetology 2020 19:89
    Content type: Original investigation Published on:

  41. The role of right ventricular (RV) and atrial (RA) structure and function, in the increased heart failure risk in (pre)diabetes is incompletely understood. The purpose of this study is to investigate the assoc...

    Authors: Pauline B. C. Linssen, Marja G. J. Veugen, Ronald M. A. Henry, Carla J. H. van der Kallen, Abraham A. Kroon, Miranda T. Schram, Hans-Peter Brunner-La Rocca and Coen D. A. Stehouwer
    Citation: Cardiovascular Diabetology 2020 19:88
    Content type: Original investigation Published on:

  42. Cardiovascular outcome trials of sodium-glucose co-transporter-2 inhibitors (SGLT2i CVOTs) found the agents to be associated with clinical benefits in terms of cardiovascular and renal outcomes. We performed a...

    Authors: Marco Castellana, Filippo Procino, Rodolfo Sardone, Pierpaolo Trimboli and Gianluigi Giannelli
    Citation: Cardiovascular Diabetology 2020 19:87
    Content type: Original investigation Published on:

  43. Type 2 diabetes mellitus (DM) is a risk factor for cardiovascular diseases and is common among patients undergoing coronary artery bypass grafting (CABG) surgery. The main objective of our study was to investi...

    Authors: Eilon Ram, Leonid Sternik, Robert Klempfner, Zaza Iakobishvili, Enrique Z. Fisman, Alexander Tenenbaum, Elchanan Zuroff, Yael Peled and Ehud Raanani
    Citation: Cardiovascular Diabetology 2020 19:86
    Content type: Original investigation Published on:

  44. Left ventricular (LV) longitudinal dysfunction has been identified in type 2 diabetes mellitus (T2DM) patients with preserved LV ejection fraction (LVEF). However, the impact of T2DM on LV longitudinal functio...

    Authors: Hidekazu Tanaka, Kazuhiro Tatsumi, Hiroki Matsuzoe, Kensuke Matsumoto and Ken-ichi Hirata
    Citation: Cardiovascular Diabetology 2020 19:84
    Content type: Original investigation Published on:

  45. Current evidence about the cardiovascular safety of glucagon-like peptide-1 receptor agonist (GLP-1ra) possesses limited generalizability to real-world patients with type 2 diabetes (T2D) in usual practice. Th...

    Authors: Chun-Ting Yang, Chen-Yi Yang, Huang-Tz Ou and Shihchen Kuo
    Citation: Cardiovascular Diabetology 2020 19:83
    Content type: Original investigation Published on:

  46. Reactive hyperemia-peripheral arterial tonometry (RH-PAT) is a noninvasive and simple test for evaluating the endothelial function. There has been sparse evidence on the usefulness of the RH-PAT index (RHI) in...

    Authors: Bo Kyung Koo, Woo-Young Chung and Min Kyong Moon
    Citation: Cardiovascular Diabetology 2020 19:82
    Content type: Original investigation Published on:

  47. There is increasing concern regarding cardiovascular risk in individuals with non-alcoholic fatty liver disease. This study was conducted to evaluate whether hepatic steatosis with or without fibrosis is assoc...

    Authors: Hyeok-Hee Lee, Yongin Cho, Young Ju Choi, Byung Wook Huh, Byung-Wan Lee, Eun Seok Kang, Seok Won Park, Bong-Soo Cha, Eun Jig Lee, Yong-ho Lee and Kap Bum Huh
    Citation: Cardiovascular Diabetology 2020 19:81
    Content type: Original investigation Published on:

  48. The triglyceride-glucose index (TyG index) has been regarded as a reliable alternative marker of insulin resistance and an independent predictor of cardiovascular outcomes. Whether the TyG index predicts adver...

    Authors: Le Wang, Hong-liang Cong, Jing-xia Zhang, Yue-cheng Hu, Ao Wei, Ying-yi Zhang, Hua Yang, Li-bin Ren, Wei Qi, Wen-yu Li, Rui Zhang and Jing-han Xu
    Citation: Cardiovascular Diabetology 2020 19:80
    Content type: Original investigation Published on:

  49. Severe obesity among children and adolescents is a significant global public health concern. The prevalence has markedly increased over the last decades, becoming common in many countries. Overwhelming rates o...

    Authors: Cole D. Bendor, Aya Bardugo, Orit Pinhas-Hamiel, Arnon Afek and Gilad Twig
    Citation: Cardiovascular Diabetology 2020 19:79
    Content type: Review Published on:

  50. Bodyweight variability is a risk factor for atrial fibrillation (AF). We aimed to examine the relationship between bodyweight variability and the risk of AF in patients with type 2 diabetes mellitus (DM), and ...

    Authors: Hyun-Jung Lee, Eue-Keun Choi, Kyung-Do Han, Da Hye Kim, Euijae Lee, So-Ryoung Lee, Seil Oh and Gregory Y. H. Lip
    Citation: Cardiovascular Diabetology 2020 19:78
    Content type: Original investigation Published on:
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