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  1. The dipeptidyl peptidase-4 (DPP-4) inhibitors Sitagliptin and Vildagliptin lower blood glucose by augmenting endogenous levels of glucagon-like peptide-1 (GLP-1), an incretin which also confers cardioprotectio...

    Authors: Derek J Hausenloy, Hannah J Whittington, Abigail M Wynne, Shah S Begum, Louise Theodorou, Niels Riksen, Mihaela M Mocanu and Derek M Yellon
    Citation: Cardiovascular Diabetology 2013 12:154
    Content type: Original investigation Published on:

  2. Detection of early vascular changes prior to clinical manifestations of atherosclerosis, such as increased arterial carotid intima-media thickness (CIMT) and impaired endothelial function is of paramount impor...

    Authors: Sema Ciftci Dogansen, Aysen Helvaci, Mine Adas and Suzan Deniz Onal
    Citation: Cardiovascular Diabetology 2013 12:153
    Content type: Original investigation Published on:

  3. The combination of systemic arterial hypertension and diabetes mellitus (DM) induces greater cardiac remodeling than either condition alone. However, this association has been poorly addressed in senescent rat...

    Authors: Camila Moreno Rosa, Natasha Priscilla Xavier, Dijon Henrique Campos, Ana Angélica Henrique Fernandes, Marcelo Diarcadia Mariano Cezar, Paula Felippe Martinez, Antonio Carlos Cicogna, Camila Gimenes, Rodrigo Gimenes, Marina Politi Okoshi and Katashi Okoshi
    Citation: Cardiovascular Diabetology 2013 12:152
    Content type: Original investigation Published on:

  4. Activation of the renin-angiotensin system (RAS) plays a critical role in the pathophysiology of myocardial infarction (MI) and the development of heart failure. Both angiotensin-converting enzyme 2 (ACE2) and...

    Authors: Wei Liu, Xinmin Zhou, Fenglei Yu, Jianguo Hu and Wen Hu
    Citation: Cardiovascular Diabetology 2013 12:151
    Content type: Original investigation Published on:

  5. Activin A released from epicardial adipose tissue has been linked to contractile dysfunction and insulin resistance in cardiomyocytes. This study investigated the role of activin A in clinical diabetic cardiom...

    Authors: Weena JY Chen, Sabrina Greulich, Rutger W van der Meer, Luuk J Rijzewijk, Hildo J Lamb, Albert de Roos, Johannes WA Smit, Johannes A Romijn, Johannes B Ruige, Adriaan A Lammertsma, Mark Lubberink, Michaela Diamant and D Margriet Ouwens
    Citation: Cardiovascular Diabetology 2013 12:150
    Content type: Original investigation Published on:

  6. Advanced glycation endproducts (AGEs) may play a role in the development of coronary artery calcification (CAC) in type 1 diabetes (T1DM). We studied plasma AGEs in association with T1DM and CAC, and whether o...

    Authors: Marcelle GA van Eupen, Miranda T Schram, Helen M Colhoun, Jean LJM Scheijen, Coen DA Stehouwer and Casper G Schalkwijk
    Citation: Cardiovascular Diabetology 2013 12:149
    Content type: Original investigation Published on:

  7. Glucagon-like peptide-1 (GLP-1) and its mimetics reduce infarct size in the setting of acute myocardial ischemia/reperfusion (I/R) injury. However, the short serum half-life of GLP-1 and its mimetics may limit...

    Authors: Weike Bao, Lucy J Holt, Rob D Prince, Gavin X Jones, Karpagam Aravindhan, Mathew Szapacs, April M Barbour, Larry J Jolivette, John J Lepore, Robert N Willette, Elena DeAngelis and Beat M Jucker
    Citation: Cardiovascular Diabetology 2013 12:148
    Content type: Original investigation Published on:

  8. The high glucose-induced proliferation of vascular smooth muscle cells (VSMCs) plays an important role in the development of diabetic vascular diseases. In a previous study, we confirmed that Interferon regula...

    Authors: Xi Zhang, Long Liu, Chao Chen, Ya-Li Chi, Xiang-Qun Yang, Yan Xu, Xiao-Tong Li, Shi-Lei Guo, Shao-Hu Xiong, Man-Ru Shen, Yu Sun, Chuan-Sen Zhang and Kai-Meng Hu
    Citation: Cardiovascular Diabetology 2013 12:147
    Content type: Original investigation Published on:

  9. The prevalence of diabetes in China is increasing rapidly. However, scarce data are available on serum electrolyte levels in Chinese adults with diabetes, especially in those with cardiovascular complications....

    Authors: Shenqi Wang, Xuhong Hou, Yu Liu, Huijuan Lu, Li Wei, Yuqian Bao and Weiping Jia
    Citation: Cardiovascular Diabetology 2013 12:146
    Content type: Original investigation Published on:

  10. Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthesis inhibitor, and insulin resistance (IR) have been implicated in atherogenesis. Our aim was to estimate relations between ADMA, the magnit...

    Authors: Olga Kruszelnicka, Andrzej Surdacki and Alain Golay
    Citation: Cardiovascular Diabetology 2013 12:145
    Content type: Original investigation Published on:

  11. Patients with type 2 diabetes mellitus (T2DM) present subclinical left ventricular systolic and/or diastolic dysfunction (LVD). Dipeptidyl peptidase-4 (DPP4) inactivates peptides that possess cardioprotective ...

    Authors: Susana Ravassa, Joaquín Barba, Isabel Coma-Canella, Ana Huerta, Begoña López, Arantxa González and Javier Díez
    Citation: Cardiovascular Diabetology 2013 12:143
    Content type: Original investigation Published on:

  12. Endothelial dysfunction precedes pathogenesis of vascular complications in diabetes. In recent years, the mechanisms of endothelial dysfunction were investigated to outline strategies for its treatment. Howeve...

    Authors: Hemang Patel, Juan Chen, Kumuda C Das and Mahendra Kavdia
    Citation: Cardiovascular Diabetology 2013 12:142
    Content type: Original investigation Published on:

  13. Accumulation of advanced glycation end products (AGEs) in the vasculature triggers a series of morphological and functional changes contributing to endothelial hyperpermeability. The reorganisation and redistr...

    Authors: Zhenyu Li, Qiaoqing Zhong, Tianlun Yang, Xiumei Xie and Meifang Chen
    Citation: Cardiovascular Diabetology 2013 12:141
    Content type: Original investigation Published on:

  14. It is a matter of debate whether metabolic syndrome (MS) improves cardiovascular risk prediction beyond the risk associated with its individual components. The present study examined the association of MS scor...

    Authors: Jong-Youn Kim, Eui-Young Choi, Hee-Sun Mun, Pil-Ki Min, Young-Won Yoon, Byoung Kwon Lee, Bum-Kee Hong, Se-Joong Rim and Hyuck Moon Kwon
    Citation: Cardiovascular Diabetology 2013 12:140
    Content type: Original investigation Published on:

  15. Development of a cardiomyopathy in diabetes mellitus is independent of traditional risk factors, with no clinical trials targeting specific therapeutic interventions. Myocardial fibrosis is one of the key mech...

    Authors: Melissa Leung, Vincent W Wong, Stephane Heritier, Anastasia S Mihailidou and Dominic Y Leung
    Citation: Cardiovascular Diabetology 2013 12:139
    Content type: Study protocol Published on:

  16. Dyslipidemia, a major risk factor for cardiovascular disease is a common finding in patients with type 2 diabetes and among women with gestational diabetes. Elevated levels of lipoprotein(a) [Lp(a)] are linked...

    Authors: Jelena Todoric, Ammon Handisurya, Karoline Leitner, Juergen Harreiter, Gregor Hoermann and Alexandra Kautzky-Willer
    Citation: Cardiovascular Diabetology 2013 12:138
    Content type: Original investigation Published on:

  17. A relationship between plasma adiponectin level and a number of metabolic conditions, including insulin resistance, obesity, and type 2 diabetes, has been reported. This study aimed to assess whether urinary a...

    Authors: Won Seon Jeon, Ji Woo Park, Namseok Lee, Se Eun Park, Eun Jung Rhee, Won Young Lee, Ki Won Oh, Sung Woo Park, Cheol-Young Park and Byung-Soo Youn
    Citation: Cardiovascular Diabetology 2013 12:137
    Content type: Original investigation Published on:

  18. To study the pathogenesis of diabetic cardiomyopathy, reliable animal models of type 2 diabetes are required. Physiologically relevant rodent models are needed, which not only replicate the human pathology but...

    Authors: Latt S Mansor, Eileen R Gonzalez, Mark A Cole, Damian J Tyler, Jessica H Beeson, Kieran Clarke, Carolyn A Carr and Lisa C Heather
    Citation: Cardiovascular Diabetology 2013 12:136
    Content type: Original investigation Published on:

  20. Increased levels of the sugar metabolite methylglyoxal (MG) in vivo were shown to participate in the pathophysiology of vascular complications in diabetes. Alterations of endothelial nitric oxide synthase (eNOS) ...

    Authors: Yang Su, Syed M Qadri, Lingyun Wu and Lixin Liu
    Citation: Cardiovascular Diabetology 2013 12:134
    Content type: Original investigation Published on:

  21. Large body of evidences accumulated in clinical and epidemiological studies indicate that hearts of diabetic subjects are more sensitive to ischemia reperfusion injury (IRI), which results in a higher rate of ...

    Authors: Haobo Li, Zipeng Liu, Junwen Wang, Gordon T Wong, Chi-Wai Cheung, Liangqing Zhang, Can Chen, Zhengyuan Xia and Michael G Irwin
    Citation: Cardiovascular Diabetology 2013 12:133
    Content type: Original investigation Published on:

  22. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) detoxifies reactive aldehydes in the micro- and macrovasculature. These substrates, including methylglyoxal and 4-hydroxynonenal formed from glucose and lipids, c...

    Authors: Kazunori Morita, Junji Saruwatari, Haruna Miyagawa, Yoshihiro Uchiyashiki, Kentaro Oniki, Misaki Sakata, Ayami Kajiwara, Akira Yoshida, Hideaki Jinnouchi and Kazuko Nakagawa
    Citation: Cardiovascular Diabetology 2013 12:132
    Content type: Original investigation Published on:

  23. The Cardiovascular Risk Evaluation in people with type 2 Diabetes on Insulin Therapy (CREDIT) study is an international, multicenter, observational study designed to assess metabolic parameters and cardiovascu...

    Authors: Ryuzo Kawamori, Koichi Node, Toshiaki Hanafusa, Yoshihito Atsumi, Yusuke Naito and Yoshitomo Oka
    Citation: Cardiovascular Diabetology 2013 12:131
    Content type: Original investigation Published on:

  25. Sulfonylureas (SUs) are commonly used in the treatment of type 2 diabetes (T2DM), usually as second-line treatment after the failure of metformin. However, SUs are associated with poor durability, hypoglycemia...

    Authors: Martin Ridderstråle, Robbyna Svaerd, Cordula Zeller, Gabriel Kim, Hans J Woerle and Uli C Broedl
    Citation: Cardiovascular Diabetology 2013 12:129
    Content type: Study protocol Published on:

  26. This study aimed to evaluate the efficacy of mesenchymal stem cell (MSC) transplantation to mitigate abnormalities in cardiac-specific and systemic metabolism mediated by a combination of a myocardial infarcti...

    Authors: Curtis C Hughey, Lianli Ma, Freyja D James, Deanna P Bracy, Zhizhang Wang, David H Wasserman, Jeffrey N Rottman, Dustin S Hittel and Jane Shearer
    Citation: Cardiovascular Diabetology 2013 12:128
    Content type: Original investigation Published on:

  27. Symptoms of heart failure with preserved left ventricular systolic function are common among patients undergoing peritoneal dialysis (PD). Epicardial fat (EpF) is an ectopic fat depot with possible paracrine o...

    Authors: Heng-Hsu Lin, Jen-Kuang Lee, Chung-Yi Yang, Yu-Chung Lien, Jenq-Wen Huang and Cho-Kai Wu
    Citation: Cardiovascular Diabetology 2013 12:127
    Content type: Original investigation Published on:

  28. Novel and robust cardiovascular (CV) markers are needed to improve CV morbidity and mortality risk prediction in type 2 diabetes (T2D). We assessed the long term predictive value of 4 novel CV risk markers for...

    Authors: Anne Pernille Ofstad, Lars Gullestad, Elsa Orvik, Svend Aakhus, Knut Endresen, Thor Ueland, Pål Aukrust, Morten W Fagerland, Kåre I Birkeland and Odd Erik Johansen
    Citation: Cardiovascular Diabetology 2013 12:126
    Content type: Original investigation Published on:

  29. Advanced glycation end products (AGEs) and receptor RAGE interaction play a role in diabetic vascular complications. Inhibition of dipeptidyl peptidase-4 (DPP-4) is a potential therapeutic target for type 2 di...

    Authors: Yuji Ishibashi, Takanori Matsui, Sayaka Maeda, Yuichiro Higashimoto and Sho-ichi Yamagishi
    Citation: Cardiovascular Diabetology 2013 12:125
    Content type: Original investigation Published on:

  30. Expression and activity of the fibroblast growth factor (FGF) 21 hormone-like protein are associated with development of several metabolic disorders. This study was designed to investigate whether serum FGF21 ...

    Authors: Yun Shen, Xiaojing Ma, Jian Zhou, Xiaoping Pan, Yaping Hao, Mi Zhou, Zhigang Lu, Meifang Gao, Yuqian Bao and Weiping Jia
    Citation: Cardiovascular Diabetology 2013 12:124
    Content type: Original investigation Published on:

  31. Intracellular calcium (Ca2+) coordinates the cardiac contraction cycle and is dysregulated in diabetic cardiomyopathy. Treatment with triethylenetetramine (TETA), a divalent-copper-selective chelator, improves ca...

    Authors: Lin Zhang, Marie-Louise Ward, Anthony RJ Phillips, Shaoping Zhang, John Kennedy, Bernard Barry, Mark B Cannell and Garth JS Cooper
    Citation: Cardiovascular Diabetology 2013 12:123
    Content type: Original investigation Published on:

  32. Authors: Joris van Ark, Hans-Peter Hammes, Marcory CRF van Dijk, Chris PH Lexis, Iwan CC van der Horst, Clark J Zeebregts, Marc G Vervloet, Bruce HR Wolffenbuttel, Harry van Goor and Jan-Luuk Hillebrands
    Citation: Cardiovascular Diabetology 2013 12:120
    Content type: Erratum Published on:

    The original article was published in Cardiovascular Diabetology 2013 12:116

  33. Non-invasive measurements of 24 hour ambulatory central aortic systolic pressure (24 h-CASP) and central pulse pressure (24 h-CPP) are now feasible. We evaluate the relationship between 24 h central blood pres...

    Authors: Simone Theilade, Maria Lajer, Tine Willum Hansen, Christel Joergensen, Frederik Persson, Gudbjörg Andrésdottir, Henrik Reinhard, Stine Elkjær Nielsen, Peter Lacy, Bryan Williams and Peter Rossing
    Citation: Cardiovascular Diabetology 2013 12:122
    Content type: Original investigation Published on:

  34. Cardiovascular risk stratification of asymptomatic diabetic patients is important and remains a difficult clinical problem. Our aim was to test the hypothesis that coronary flow reserve (CFR) assessed by nonin...

    Authors: Takayuki Kawata, Masao Daimon, Rei Hasegawa, Tomohiko Toyoda, Tai Sekine, Toshiharu Himi, Daigaku Uchida, Sakiko Miyazaki, Kuniaki Hirose, Ryoko Ichikawa, Masaki Maruyama, Hiromasa Suzuki and Hiroyuki Daida
    Citation: Cardiovascular Diabetology 2013 12:121
    Content type: Original investigation Published on:

  35. Nicotinamide phosphoribosyltransferase (NAMPT) is the limiting enzyme in one of pathways of synthesis of Nicotinamide Adenine Dinucleotide, a redox coenzyme. NAMPT is considered as an insulin-mimetic factor an...

    Authors: Pedro Saddi-Rosa, Carolina Soares Oliveira, Felipe Crispim, Fernando MA Giuffrida, Valter Correia de Lima, José Gilberto Vieira, Alessandro Doria, Gilberto Velho and André Fernandes Reis
    Citation: Cardiovascular Diabetology 2013 12:119
    Content type: Original investigation Published on:

  36. Limitations of the currently recommended stepwise treatment pathway for type 2 diabetes mellitus (T2DM), especially the failure of monotherapies to maintain good glycemic control, have prompted use of early, m...

    Authors: Li-Nong Ji, Chang-Yu Pan, Ju-Ming Lu, Hong Li, Qiang Li, Qi-Fu Li, Yong-De Peng, Hao-Ming Tian, Chen Yao, Zhi-Gang Zhao, Ru-Ya Zhang, Xiang-Ling Wang and Lei Wang
    Citation: Cardiovascular Diabetology 2013 12:118
    Content type: Study protocol Published on:

  37. GLP-1 is an incretine hormone which gets secreted from intestinal L-cells in response to nutritional stimuli leading to pancreatic insulin secretion and suppression of glucagon release. GLP-1 further inhibits ...

    Authors: Katja Piotrowski, Melanie Becker, Julia Zugwurst, Ingeborg Biller-Friedmann, Gerald Spoettl, Martin Greif, Alexander W Leber, Alexander Becker, Rüdiger P Laubender, Corinna Lebherz, Burkhard Goeke, Nikolaus Marx, Klaus G Parhofer and Michael Lehrke
    Citation: Cardiovascular Diabetology 2013 12:117
    Content type: Original investigation Published on:

  38. Diabetes is associated with a high incidence of macrovascular disease (MVD), including peripheral and coronary artery disease. Circulating soluble-Klotho (sKlotho) is produced in the kidney and is a putative a...

    Authors: Joris van Ark, Hans-Peter Hammes, Marcory C R F van Dijk, Marc G Vervloet, Bruce H R Wolffenbuttel, Harry van Goor and Jan-Luuk Hillebrands
    Citation: Cardiovascular Diabetology 2013 12:116
    Content type: Original investigation Published on:

    The Erratum to this article has been published in Cardiovascular Diabetology 2013 12:120

  39. We used Laser Doppler Fluximetry (LDF) to define "normal" endothelial function in a large cohort of healthy children and adolescents and to evaluate skin microcirculation in paediatric patients with type 1 dia...

    Authors: Mirjam Heimhalt-El Hamriti, Corinna Schreiver, Anja Noerenberg, Julia Scheffler, Ulrike Jacoby, Dieter Haffner and Dagmar-C Fischer
    Citation: Cardiovascular Diabetology 2013 12:115
    Content type: Original investigation Published on:

  40. Cardiac nestin(+) cells exhibit properties of a neural progenitor/stem cell population characterized by the de novo synthesis of neurofilament-M in response to ischemic injury and 6-hydroxydopamine administration...

    Authors: Andreanne Chabot, Marc-Andre Meus, Vanessa Hertig, Natacha Duquette and Angelino Calderone
    Citation: Cardiovascular Diabetology 2013 12:114
    Content type: Original investigation Published on:

  41. Little or no research has determined the effect of vitamin D3 supplementation in conjunction with pharmacological and non-pharmacological approaches in the diabetes mellitus type 2 (DMT2) patients. The objecti...

    Authors: Khalid M Alkharfy, Nasser M Al-Daghri, Shaun B Sabico, Abdulaziz Al-Othman, Osama Moharram, Majed S Alokail, Yousef Al-Saleh, Sudhesh Kumar and George P Chrousos
    Citation: Cardiovascular Diabetology 2013 12:113
    Content type: Original investigation Published on:

  42. Qualitative alterations of lipoproteins underlie the high incidence of atherosclerosis in diabetes. The objective of this study was to assess the impact of low-density lipoprotein (LDL) subfraction phenotype o...

    Authors: Jose Luis Sánchez-Quesada, Irene Vinagre, Elena De Juan-Franco, Juan Sánchez-Hernández, Rosa Bonet-Marques, Francisco Blanco-Vaca, Jordi Ordóñez-Llanos and Antonio Pérez
    Citation: Cardiovascular Diabetology 2013 12:112
    Content type: Original investigation Published on:

  43. Activation of RhoA/Rho-kinase (ROCK) is increasingly implicated in acute vasospasm and chronic vasoconstriction in major organ systems. Therefore we aimed to ascertain whether an increase in ROCK activity play...

    Authors: James T Pearson, Mathew J Jenkins, Amanda J Edgley, Takashi Sonobe, Mandar Joshi, Mark T Waddingham, Yutaka Fujii, Daryl O Schwenke, Hirotsugu Tsuchimochi, Misa Yoshimoto, Keiji Umetani, Darren J Kelly and Mikiyasu Shirai
    Citation: Cardiovascular Diabetology 2013 12:111
    Content type: Original investigation Published on:

  44. Low-grade albuminuria is associated with cardiovascular risk factors and mortality. Our aim was to investigate the association between low-grade albuminuria and carotid atherosclerotic lesions in community-bas...

    Authors: Mei-Fang Li, Yin-Fang Tu, Lian-Xi Li, Jun-Xi Lu, Xue-Hong Dong, Li-Bo Yu, Rong Zhang, Yu-Qian Bao, Wei-Ping Jia and Ren-Ming Hu
    Citation: Cardiovascular Diabetology 2013 12:110
    Content type: Original investigation Published on:

  45. Left ventricular hypertrophy has multiple aetiologies including diabetes and genetic factors. We aimed to identify genetic variants predicting left ventricular hypertrophy in diabetic individuals.

    Authors: Helen M Parry, Louise A Donnelly, Natalie Van Zuydam, Alexander SF Doney, Douglas HJ Elder, Andrew D Morris, Alan D Struthers, Colin NA Palmer and Chim C Lang
    Citation: Cardiovascular Diabetology 2013 12:109
    Content type: Original investigation Published on:

  46. Circulatory and tissue renin-angiotensin systems (RAS) play a central role in cardiovascular (CV) and renal pathophysiology, making RAS inhibition a logical therapeutic approach in the prevention of CV and ren...

    Authors: Samir G Mallat
    Citation: Cardiovascular Diabetology 2013 12:108
    Content type: Review Published on:

  47. The arterial system in diabetic patients is characterized by generalized non-atherosclerotic alterations in the vascular extracellular matrix causing increased arterial stiffness compared with subjects without...

    Authors: Esben Laugesen, Pernille Høyem, Jens Sandahl Christiansen, Søren Tang Knudsen, Klavs Würgler Hansen, W Scott Argraves, Troels Krarup Hansen, Per Løgstrup Poulsen and Lars Melholt Rasmussen
    Citation: Cardiovascular Diabetology 2013 12:107
    Content type: Original investigation Published on:

  48. Insulin resistance (IR) is the key feature of the metabolic syndrome (MetS); its association with peripheral arterial disease (PAD) is unclear. We hypothesized that IR is associated with both the MetS and sono...

    Authors: Alexander Vonbank, Christoph H Saely, Philipp Rein and Heinz Drexel
    Citation: Cardiovascular Diabetology 2013 12:106
    Content type: Original investigation Published on:

  49. Adipokines, including adipocyte fatty acid-binding protein (A-FABP), have been demonstrated to be involved in the pathogenesis of atherosclerosis. In the present study, we investigated the association of circu...

    Authors: Chi-Lun Huang, Yen-Wen Wu, Chih-Cheng Wu, Lin Lin, Yu-Chin Wu, Pei-Ying Hsu, Yuh-Shiun Jong and Wei-Shiung Yang
    Citation: Cardiovascular Diabetology 2013 12:105
    Content type: Original investigation Published on:

  50. Dyslipidemia is a common complication in patients with diabetes and is involved in being prone to cardiovascular disease. The risk of coronary artery disease is known to be lower in light-to-moderate drinkers ...

    Authors: Tomoko Shimomura and Ichiro Wakabayashi
    Citation: Cardiovascular Diabetology 2013 12:104
    Content type: Original investigation Published on:
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Cardiovascular Diabetology

ISSN: 1475-2840