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  1. To investigate whether atherogenic dyslipidemia, a dyslipidemic profile combining elevated triglycerides and low high-density lipoprotein (HDL) cholesterol, is predictive of risk of silent myocardial ischemia ...

    Authors: Paul Valensi, Antoine Avignon, Ariane Sultan, Bernard Chanu, Minh Tuan Nguyen and Emmanuel Cosson
    Citation: Cardiovascular Diabetology 2016 15:104
    Content type: Original investigation Published on:

  2. Authors: Ana Lopez-de-Andrés, Isabel Jiménez-Trujillo, Rodrigo Jiménez-García, Valentín Hernández-Barrera, José Mª de Miguel-Yanes, Manuel Méndez-Bailón, Napoleón Perez-Farinos, Miguel Ángel Salinero-Fort and Pilar Carrasco-Garrido
    Citation: Cardiovascular Diabetology 2016 15:103
    Content type: Erratum Published on:

    The original article was published in Cardiovascular Diabetology 2015 14:48

  3. The prevalence of type 2 diabetes (T2DM) in younger adults is growing. Compared to the late onset T2DM, it is well recognized that the disease tends to behave more aggressively in the younger age group with ev...

    Authors: Z. Z. Htike, T. Yates, E. M. Brady, D. Webb, L. J. Gray, D. Swarbrick, G. P. McCann, K. Khunti and M. J. Davies
    Citation: Cardiovascular Diabetology 2016 15:102
    Content type: Study protocol Published on:

  4. Strict glycaemic control in patients with type 2 diabetes has proven to have microvascular benefits while the effects on CVD and mortality are less clear, especially in high risk patients. Whether strict glyca...

    Authors: Sophie H. Bots, Yolanda van der Graaf, Hendrik M. W. Nathoe, Gert Jan de Borst, Jaap L. Kappelle, Frank L. J. Visseren and Jan Westerink
    Citation: Cardiovascular Diabetology 2016 15:101
    Content type: Original investigation Published on:

  5. Deferred revascularisation based upon fractional flow reserve (FFR >0.80) is associated with a low incidence of target lesion failure (TLF). Whether deferred revascularisation is also as safe in diabetes melli...

    Authors: Mark W. Kennedy, Eliza Kaplan, Rik S. Hermanides, Enrico Fabris, Veemal Hemradj, Petra C. Koopmans, Jan-Hank E. Dambrink, A. T. Marcel Gosselink, Arnoud W. J. van‘t Hof, Jan Paul Ottervanger, Vincent Roolvink, Wouter S. Remkes, Aize van der Sluis, Harry Suryapranata and Elvin Kedhi
    Citation: Cardiovascular Diabetology 2016 15:100
    Content type: Original investigation Published on:

  6. Glucagon-like peptide-1 (7–36) amide (GLP-1) protects against stunning and cumulative left ventricular dysfunction in humans. The mechanism remains uncertain but GLP-1 may act by opening mitochondrial K-ATP ch...

    Authors: Joel P. Giblett, Richard G. Axell, Paul A. White, Sophie J. Clarke, Liam McCormick, Philip A. Read, Johannes Reinhold, Adam J. Brown, Michael O’Sullivan, Nick E. J. West, David P. Dutka and Stephen P. Hoole
    Citation: Cardiovascular Diabetology 2016 15:99
    Content type: Original investigation Published on:

  7. Diabetes mellitus (DM) is associated to the morphological and componential characteristics of atheromatous plaques. It has proven that plaque textures are related to plaque components and beneficial for athero...

    Authors: Xiao-Wei Huang, Yan-Ling Zhang, Long Meng, Ming Qian, Wei Zhou, Rong-Qin Zheng, Hai-Rong Zheng and Li–Li Niu
    Citation: Cardiovascular Diabetology 2016 15:98
    Content type: Original investigation Published on:

  8. Heart failure (HF) and diabetes (DM) are a lethal combination. The current armamentarium of anti-diabetic agents has been shown to be less efficacious and sometimes even harmful in diabetic patients with conco...

    Authors: Jagdeep S. S. Singh, Amir Fathi, Keeran Vickneson, Ify Mordi, Mohapradeep Mohan, J. Graeme Houston, Ewan R. Pearson, Allan D. Struthers and Chim C. Lang
    Citation: Cardiovascular Diabetology 2016 15:97
    Content type: Methodology Published on:

  9. The effects of insulin on cardiomyocytes, such as positive inotropic action and glucose uptake are well described. However, in vitro studies comparing long-acting insulin analogues with regard to cardiomyocyte...

    Authors: Thorsten Hartmann, Sabrina Overhagen, D. Margriet Ouwens, Silja Raschke, Paulus Wohlfart, Norbert Tennagels, Nina Wronkowitz and Jürgen Eckel
    Citation: Cardiovascular Diabetology 2016 15:96
    Content type: Original investigation Published on:

  11. Vascular stiffening, a risk factor for cardiovascular disease, is accelerated, particularly in women with obesity and type 2 diabetes. Preclinical evidence suggests that dipeptidylpeptidase-4 (DPP-4) inhibitor...

    Authors: Camila Manrique, Javad Habibi, Annayya R. Aroor, James R. Sowers, Guanghong Jia, Melvin R. Hayden, Mona Garro, Luis A. Martinez-Lemus, Francisco I. Ramirez-Perez, Thomas Klein, Gerald A. Meininger and Vincent G. DeMarco
    Citation: Cardiovascular Diabetology 2016 15:94
    Content type: Original investigation Published on:

  12. Obesity is associated with multiple adverse cardiovascular conditions and may increase the risk of ventricular tachyarrhythmias (VT/VF). There is limited data on the association between obesity and risk of VT/...

    Authors: Barbara Szepietowska, Bronislava Polonsky, Saadia Sherazi, Yitschak Biton, Valentina Kutyifa, Scott McNitt, Mehmet Aktas, Arthur J. Moss and Wojciech Zareba
    Citation: Cardiovascular Diabetology 2016 15:93
    Content type: Original investigation Published on:

  13. It is not clear how severe metabolic syndrome (MS) affects the development of coronary atherosclerosis.

    Authors: Lee Kyung Kim, Ji Won Yoon, Dong-Hwa Lee, Kyoung Min Kim, Sung Hee Choi, Kyong Soo Park, Hak Chul Jang, Min-Kyung Kim, Hyo Eun Park, Su-Yeon Choi and Soo Lim
    Citation: Cardiovascular Diabetology 2016 15:92
    Content type: Original investigation Published on:

  14. To evaluate the role of the autonomic nervous system (ANS) in the development of insulin resistance (IR) and assess the relationship between IR and activity of ANS using power spectrum analysis of heart rate v...

    Authors: Maria K. Svensson, Stina Lindmark, Urban Wiklund, Peter Rask, Marcus Karlsson, Jan Myrin, Joel Kullberg, Lars Johansson and Jan W. Eriksson
    Citation: Cardiovascular Diabetology 2016 15:91
    Content type: Original investigation Published on:

  15. Omentin-1, a novel adipocytokine mainly expressed in visceral adipose tissue, has been found to inhibit the inflammatory response and improve insulin resistance as well as other obesity-related disorders. This...

    Authors: Yu Du, Qingwei Ji, Lun Cai, Fangjiong Huang, Yongqiang Lai, Yue Liu, Jianbo Yu, Bo Han, Enjun Zhu, Jinwei Zhang, Yujie Zhou, Zhijian Wang and Yingxin Zhao
    Citation: Cardiovascular Diabetology 2016 15:90
    Content type: Original investigation Published on:

  16. Combination therapy with canagliflozin and insulin was investigated in a prescribed substudy of the canagliflozin Cardiovascular Assessment Study (CANVAS); however, it was not evaluated in Japanese patients wi...

    Authors: Nobuya Inagaki, Shin-ichi Harashima, Nobuko Maruyama, Yutaka Kawaguchi, Maki Goda and Hiroaki Iijima
    Citation: Cardiovascular Diabetology 2016 15:89
    Content type: Original investigation Published on:

  17. Endothelial dysfunction has been suggested as a possible causal link between hyperglycemia and microvascular complications in diabetes mellitus. The effect of metformin on endothelial progenitor cells (EPCs) i...

    Authors: Jia-Wen Yu, Ya-Ping Deng, Xue Han, Guo-Fei Ren, Jian Cai and Guo-Jun Jiang
    Citation: Cardiovascular Diabetology 2016 15:88
    Content type: Original investigation Published on:

  18. Xanthine oxidase inhibitors are anti-hyperuricemic drugs that decrease serum uric acid levels by inhibiting its synthesis. Xanthine oxidase is also recognized as a pivotal enzyme in the production of oxidative...

    Authors: Jun-ichi Oyama, Atsushi Tanaka, Yasunori Sato, Hirofumi Tomiyama, Masataka Sata, Tomoko Ishizu, Isao Taguchi, Takanori Kuroyanagi, Hiroki Teragawa, Nobukazu Ishizaka, Yumiko Kanzaki, Mitsuru Ohishi, Kazuo Eguchi, Yukihito Higashi, Hirotsugu Yamada, Koji Maemura…
    Citation: Cardiovascular Diabetology 2016 15:87
    Content type: Study protocol Published on:

  19. There is an increasing appreciation for a series of less traditional risk factors that should not be ignored when considering type 2 diabetes, obesity, hypertension, and cardiovascular disease. These include a...

    Authors: Craig L. Hanis, Susan Redline, Brian E. Cade, Graeme I. Bell, Nancy J. Cox, Jennifer E. Below, Eric L. Brown and David Aguilar
    Citation: Cardiovascular Diabetology 2016 15:86
    Content type: Original investigation Published on:

  21. To assess the 9-year changes of the incidence and characteristics of metabolic syndrome (MetS) in Chinese community under the background of dramatically changed environment.

    Authors: Boren Jiang, Bin Li, Yongbin Wang, Bing Han, Ningjian Wang, Qin Li, Weihong Yang, Guolan Huang, Jinhua Wang, Yi Chen, Yingchao Chen, Chunfang Zhu, Dongping Lin and Yingli Lu
    Citation: Cardiovascular Diabetology 2016 15:84
    Content type: Original investigation Published on:

  22. In patients with type 2 diabetes, the prognostic impact of an orthostatic rise in blood pressure is not known. Therefore, the aim of this study was to determine the prognostic implications of the diastolic ort...

    Authors: Magnus Wijkman, Toste Länne, Carl Johan Östgren and Fredrik H. Nystrom
    Citation: Cardiovascular Diabetology 2016 15:83
    Content type: Original investigation Published on:

  23. Hyperglycemia is acknowledged as a pro-inflammatory condition and a major cause of vascular damage. Nevertheless, we have previously described that high glucose only promotes inflammation in human vascular cel...

    Authors: Concepción Peiró, Tania Romacho, Verónica Azcutia, Laura Villalobos, Emilio Fernández, Juan P. Bolaños, Salvador Moncada and Carlos F. Sánchez-Ferrer
    Citation: Cardiovascular Diabetology 2016 15:82
    Content type: Original investigation Published on:

    The Erratum to this article has been published in Cardiovascular Diabetology 2017 16:25

  24. The risk for a first myocardial infarction (MI) in people with diabetes has been shown to be as high as the risk for a new MI in non-diabetic patients with a prior MI. Consequently, risk-reducing statin therap...

    Authors: Martin Bødtker Mortensen, Imra Kulenovic and Erling Falk
    Citation: Cardiovascular Diabetology 2016 15:81
    Content type: Original Investigation Published on:

  25. We have previously shown that a Palaeolithic diet consisting of the typical food groups that our ancestors ate during the Palaeolithic era, improves cardiovascular disease risk factors and glucose control comp...

    Authors: Maelán Fontes-Villalba, Staffan Lindeberg, Yvonne Granfeldt, Filip K. Knop, Ashfaque A. Memon, Pedro Carrera-Bastos, Óscar Picazo, Madhvi Chanrai, Jan Sunquist, Kristina Sundquist and Tommy Jönsson
    Citation: Cardiovascular Diabetology 2016 15:80
    Content type: Original investigation Published on:

  26. Several studies have revealed that glucose fluctuations provoke oxidative stress that leads to endothelial cell dysfunction, progression of coronary atherosclerosis, and plaque vulnerability. However, little i...

    Authors: Masaru Kuroda, Toshiro Shinke, Hiromasa Otake, Daisuke Sugiyama, Tomofumi Takaya, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Natsuko Tahara, Daiji Kashiwagi, Koji Kuroda, Yuto Shinkura, Yoshinori Nagasawa, Kazuhiko Sakaguchi, Yushi Hirota, Wataru Ogawa…
    Citation: Cardiovascular Diabetology 2016 15:79
    Content type: Original investigation Published on:

  27. To identify possible differences in cardiovascular (CV) risk among different insulin therapies, we performed pre-specified meta-analyses across the clinical program for basal insulin peglispro (BIL), in patien...

    Authors: Byron J. Hoogwerf, A. Michael Lincoff, Angel Rodriguez, Lei Chen and Yongming Qu
    Citation: Cardiovascular Diabetology 2016 15:78
    Content type: Original investigation Published on:

  28. Impaired vasoreactivity is often observed in subjects with metabolic syndrome, a condition that includes the presence of a specific cluster of risk factors for obesity and cardiovascular disease. However, hier...

    Authors: Michio Shimabukuro, Namio Higa, Hiroaki Masuzaki, Masataka Sata and Shinichiro Ueda
    Citation: Cardiovascular Diabetology 2016 15:77
    Content type: Original investigation Published on:

  29. The aim of the present study was to elucidate the effect of teneligliptin on oxidative stress and endothelial function in Japanese patients with type 2 diabetes and chronic kidney disease (CKD).

    Authors: Masaaki Sagara, Kunihiro Suzuki, Chie Aoki, Seiichi Tanaka, Isao Taguchi, Teruo Inoue and Yoshimasa Aso
    Citation: Cardiovascular Diabetology 2016 15:76
    Content type: Original investigation Published on:

  30. Type-2 diabetics have an increased risk of cardiomyopathy, and heart failure is a major cause of death among these patients. Growing evidence indicates that proinflammatory cytokines may induce the development...

    Authors: Sevil Korkmaz-Icöz, Samer Al Said, Tamás Radovits, Shiliang Li, Maik Brune, Péter Hegedűs, Ayhan Atmanli, Mihály Ruppert, Paige Brlecic, Lorenz Heyne Lehmann, Bernd Lahrmann, Niels Grabe, Yutaka Yoshikawa, Hiroyuki Yasui, Patrick Most, Matthias Karck…
    Citation: Cardiovascular Diabetology 2016 15:75
    Content type: Original investigation Published on:

  31. Previous studies have reported an increasing prevalence of metabolic abnormalities in immigrants who moved from low-cardiovascular-risk regions to Western countries, but little is known about time trends follo...

    Authors: Yonatan Reuven, Jacob Dreiher and Pesach Shvartzman
    Citation: Cardiovascular Diabetology 2016 15:74
    Content type: Original investigation Published on:

  32. Low birth weight is associated with increased rates of obesity, insulin resistance and type 2 diabetes, but the precise mechanisms for this association remain unclear. We aimed to assess the relationships betw...

    Authors: François R. Jornayvaz, Peter Vollenweider, Murielle Bochud, Vincent Mooser, Gérard Waeber and Pedro Marques-Vidal
    Citation: Cardiovascular Diabetology 2016 15:73
    Content type: Original investigation Published on:

  33. To analyze whether medical care is in accordance with guidelines for secondary prevention of myocardial infarction (MI), or stroke in patients with type 2 diabetes from Germany and Austria.

    Authors: Barbara Bohn, Christof Schöfl, Vincent Zimmer, Michael Hummel, Nikolai Heise, Erhard Siegel, Wolfram Karges, Michaela Riedl and Reinhard W. Holl
    Citation: Cardiovascular Diabetology 2016 15:72
    Content type: Original investigation Published on:

  34. Intracellular antioxidant response to high glucose is mediated by Cu/Mn-superoxide dismutases (SOD-1/SOD-2), catalase (CAT) and glutathione peroxidases (GPx), particularly glutathione peroxidase-1 (GPx-1). Alt...

    Authors: Lucia La Sala, Monica Cattaneo, Valeria De Nigris, Gemma Pujadas, Roberto Testa, Anna R. Bonfigli, Stefano Genovese and Antonio Ceriello
    Citation: Cardiovascular Diabetology 2016 15:71
    Content type: Original investigation Published on:

  35. Selenoprotein S (SelS) is a transmembrane protein that is expressed in the liver, skeletal muscle, adipose tissue, pancreatic islets, kidney, and blood vessels. In addition to its transmembrane localization, S...

    Authors: Shan-shan Yu, Li–li Men, Jia-ling Wu, Li-wei Huang, Qian Xing, Jun-jie Yao, Yong-bo Wang, Gui-rong Song, Hui-shu Guo, Guo-hua Sun, Yu-hong Zhang, Hua Li and Jian-ling Du
    Citation: Cardiovascular Diabetology 2016 15:70
    Content type: Original investigation Published on:

  36. To evaluate the clinical value of metabolic syndrome based on different definitions [American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI), International Diabetes Federation (IDF) and...

    Authors: Thijs T. W. van Herpt, Abbas Dehghan, Mandy van Hoek, M. Arfan Ikram, Albert Hofman, Eric J. G. Sijbrands and Oscar H. Franco
    Citation: Cardiovascular Diabetology 2016 15:69
    Content type: Original investigation Published on:

  37. Microvascular function is impaired in patients with stable coronary artery disease. The aim was to study microvascular function in patients with diabetes and acute coronary syndrome (ACS).

    Authors: Nikolaos Östlund Papadogeorgos, Gun Jörneskog, Mattias Bengtsson, Thomas Kahan and Majid Kalani
    Citation: Cardiovascular Diabetology 2016 15:66
    Content type: Original investigation Published on:

  38. Previous evidences have shown the presence of a prolonged and exaggerated postprandial response in type 2 diabetes mellitus (T2DM) and its relation with an increase of cardiovascular risk. However, the respons...

    Authors: A. Leon-Acuña, J. F. Alcala-Diaz, J. Delgado-Lista, J. D. Torres-Peña, J. Lopez-Moreno, A. Camargo, A. Garcia-Rios, C. Marin, F. Gomez-Delgado, J. Caballero, B. Van-Ommen, M. M. Malagon, P. Perez-Martinez and J. Lopez-Miranda
    Citation: Cardiovascular Diabetology 2016 15:68
    Content type: Original investigation Published on:

  39. Low-grade systemic inflammation is considered to participate in the progression of type 2 diabetes (T2D) and in diabetic complications.

    Authors: Bernt Johan von Scholten, Alexander Rosendahl, Philip Hasbak, Regine Bergholdt, Andreas Kjaer, Peter Rossing and Tine W. Hansen
    Citation: Cardiovascular Diabetology 2016 15:67
    Content type: Original investigation Published on:

  40. Glucagon-like peptide-1 (GLP-1) therapies are routinely used for glycaemic control in diabetes and their emerging cardiovascular actions have been a major recent research focus. In addition to GLP-1 receptor a...

    Authors: Emma Robinson, Mitchel Tate, Samuel Lockhart, Claire McPeake, Karla M. O’Neill, Kevin S. Edgar, Danielle Calderwood, Brian D. Green, Barbara J. McDermott and David J. Grieve
    Citation: Cardiovascular Diabetology 2016 15:65
    Content type: Original investigation Published on:

  41. Whole body dual-energy X-ray absorptiometry (DXA) can simultaneously measure both regional fat and non-fat mass. Android-to-gynoid (A/G) ratio measured by DXA has been reported to be associated with cardiovasc...

    Authors: Ryotaro Bouchi, Yujiro Nakano, Norihiko Ohara, Takato Takeuchi, Masanori Murakami, Masahiro Asakawa, Yuriko Sasahara, Mitsuyuki Numasawa, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto and Yoshihiro Ogawa
    Citation: Cardiovascular Diabetology 2016 15:64
    Content type: Original Investigation Published on:

  42. Vascular dysfunction is a distinctive phenotype in diabetes mellitus. Current treatments mostly focus on the tight glycemic control and few of these treatments have been designed to directly recover the vascul...

    Authors: Yu-Guang Ma, Yin-Bin Zhang, Yun-Gang Bai, Zhi-Jun Dai, Liang Liang, Mei Liu, Man-Jiang Xie and Hai-Tao Guan
    Citation: Cardiovascular Diabetology 2016 15:63
    Content type: Original investigation Published on:

  43. Diabetic patients suffer from undesired intimal hyperplasia after angioplasty. Nicorandil has a trend to reduce the rate of target lesion revascularization. However, whether nicorandil inhibits intimal hyperpl...

    Authors: Ying Qian Zhang, Feng Tian, Ying Zhou, Yun Dai Chen, Bo Li, Qiang Ma and Ying Zhang
    Citation: Cardiovascular Diabetology 2016 15:62
    Content type: Original investigation Published on:

  44. Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor ß family and has been associated with inflammation, cancer, aging, diabetes mellitus (DM) and atherosclerosis. Determinan...

    Authors: Serdar Farhan, Matthias K. Freynhofer, Ivan Brozovic, Veronika Bruno, Birgit Vogel, Ioannis Tentzeris, Sabina Baumgartner-Parzer, Kurt Huber and Alexandra Kautzky-Willer
    Citation: Cardiovascular Diabetology 2016 15:60
    Content type: Original investigation Published on:

  45. The German Diabetes Study (GDS) is a prospective longitudinal cohort study describing the impact of subphenotypes on the course of the disease. GDS aims at identifying prognostic factors and mechanisms underly...

    Authors: Julia Szendroedi, Aaruni Saxena, Katharina S. Weber, Klaus Strassburger, Christian Herder, Volker Burkart, Bettina Nowotny, Andrea Icks, Oliver Kuss, Dan Ziegler, Hadi Al-Hasani, Karsten Müssig and Michael Roden
    Citation: Cardiovascular Diabetology 2016 15:59
    Content type: Study protocol Published on:

  46. Whether body composition is associated with the N-terminal pro-B-type natriuretic peptide (NT-proBNP) level and its prognostic performance in acute coronary syndrome (ACS) remains unknown. We aimed to investig...

    Authors: Fang-Yang Huang, Hua Wang, Bao-Tao Huang, Wei Liu, Yong Peng, Chen Zhang, Tian-Li Xia, Peng-Ju Wang, Zhi-Liang Zuo, Yue Heng, Rui-Shuang Liu, Xiao-Bo Pu, Yi-Yue Gui, Shi-Jian Chen, Ye Zhu and Mao Chen
    Citation: Cardiovascular Diabetology 2016 15:58
    Content type: Original investigation Published on:

  47. Low socioeconomic status (SES) is associated with adverse cardiovascular risk factor patterns and poor outcomes in patients with diabetes. The aim of this study was to determine whether SES is associated with ...

    Authors: Xiaoming Tao, Jihu Li, Xiaolin Zhu, Bin Zhao, Jiao Sun, Linong Ji, Dayi Hu, Changyu Pan, Yuxin Huang, Suyuan Jiang, Qiang Feng and Cuiping Jiang
    Citation: Cardiovascular Diabetology 2016 15:61
    Content type: Original investigation Published on:

  48. Because type 2 diabetes mellitus is associated strongly with an increased risk of cardiovascular diseases, the number of patients with diabetes with chronic heart failure is increasing steadily. However, clini...

    Authors: Atsushi Tanaka, Teruo Inoue, Masafumi Kitakaze, Jun-ichi Oyama, Masataka Sata, Isao Taguchi, Wataru Shimizu, Hirotaka Watada, Hirofumi Tomiyama, Junya Ako, Yasushi Sakata, Toshihisa Anzai, Masaaki Uematsu, Makoto Suzuki, Kazuo Eguchi, Akira Yamashina…
    Citation: Cardiovascular Diabetology 2016 15:57
    Content type: Study protocol Published on:

  49. Contemporary guidelines recommend angiotensin-converting-enzyme inhibitors (ACEi) or angiotensin-receptor blockers (ARB) for hypertensive patients with diabetes. However, there is limited data to evaluate the ...

    Authors: Lung-Sheng Wu, Shang-Hung Chang, Gwo-Jyh Chang, Jia-Rou Liu, Yi-Hsin Chan, Hsin-Fu Lee, Ming-Shien Wen, Wei-Jan Chen, Yung-Hsin Yeh, Chi-Tai Kuo and Lai-Chu See
    Citation: Cardiovascular Diabetology 2016 15:56
    Content type: Original investigation Published on:
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Cardiovascular Diabetology

ISSN: 1475-2840