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  1. Genome-wide association studies (GWAS) are useful to reveal an association between single nucleotide polymorphisms and different measures of obesity. A multitude of new loci has recently been reported, but the...

    Authors: Peter M Schmid, Iris Heid, Christa Buechler, Andreas Steege, Markus Resch, Christoph Birner, Dierk H Endemann, Guenter A Riegger and Andreas Luchner
    Citation: Cardiovascular Diabetology 2012 11:48
    Content type: Original investigation Published on:

  2. Endothelial progenitor cells (EPCs), especially late EPCs, play a critical role in endothelial maintenance and repair, and postnatal vasculogenesis. Advanced glycation end products (AGEs) have been shown to im...

    Authors: Hong Li, Xiaoyun Zhang, Xiumei Guan, Xiaodong Cui, Yuliang Wang, Hairong Chu and Min Cheng
    Citation: Cardiovascular Diabetology 2012 11:46
    Content type: Original investigation Published on:

  4. Metabolic abnormalities have a cumulative effect on development of diabetes, but only central obesity has been defined as the essential criterion of metabolic syndrome (MetS) by the International Diabetes Fede...

    Authors: I-Te Lee, Yen-Feng Chiu, Chii-Min Hwu, Chih-Tsueng He, Fu-Tien Chiang, Yu-Chun Lin, Themistocles Assimes, J David Curb and Wayne H-H Sheu
    Citation: Cardiovascular Diabetology 2012 11:43
    Content type: Original investigation Published on:

  5. Connective tissue growth factor (CTGF) has been implicated in the cardiac and kidney complications of type 2 diabetes, and the CTGF − 945 G/C polymorphism is associated with susceptibility to systemic sclerosis, ...

    Authors: Sheila K Patel, Bryan Wai, Richard J MacIsaac, Sharon Grant, Elena Velkoska, Michelle Ord, Sianna Panagiotopoulos, George Jerums, Piyush M Srivastava and Louise M Burrell
    Citation: Cardiovascular Diabetology 2012 11:42
    Content type: Original investigation Published on:

  6. Uncoupling protein 2 (UCP2) gene polymorphisms have been reported as genetic risk factors for obesity and type 2 diabetes mellitus (T2DM). We examined the association of commonly observed UCP2 G(−866)A (rs6593...

    Authors: Sukma Oktavianthi, Hidayat Trimarsanto, Clarissa A Febinia, Ketut Suastika, Made R Saraswati, Pande Dwipayana, Wibowo Arindrarto, Herawati Sudoyo and Safarina G Malik
    Citation: Cardiovascular Diabetology 2012 11:41
    Content type: Original investigation Published on:

  7. Serum C-reactive protein (CRP) and leptin levels have been independently associated with the cardiovascular risk factors. The aim of the present study was to determine if their serum levels were associated wit...

    Authors: Feng-Hsiang Chiu, Chung Hsun Chuang, Wen-Cheng Li, Yi-Ming Weng, Wen-Chih Fann, Hsiang-Yun Lo, Cheng Sun and Shih-Hao Wang
    Citation: Cardiovascular Diabetology 2012 11:40
    Content type: Original investigation Published on:

  9. Reduced lung function is associated with incident insulin resistance and diabetes. The aim of this study was to assess the relationship between lung function and incident type 2 diabetes in Korean men.

    Authors: Chang-Hee Kwon, Eun-Jung Rhee, Jae-Uk Song, Jung-Tae Kim, Hyon Joo Kwag and Ki-Chul Sung
    Citation: Cardiovascular Diabetology 2012 11:38
    Content type: Original investigation Published on:

  11. The most common apolipoprotein E (apoE) gene polymorphism has been found to influence plasma lipid concentration and its correlation with coronary artery disease (CAD) has been extensively investigated in the ...

    Authors: Rajesh Chaudhary, Atip Likidlilid, Thavatchai Peerapatdit, Damras Tresukosol, Sorachai Srisuma, Suphachai Ratanamaneechat and Charn Sriratanasathavorn
    Citation: Cardiovascular Diabetology 2012 11:36
    Content type: Original investigation Published on:

  12. Health utility (HU) measures are used as overall measures of quality of life and to determine quality adjusted life years (QALYs) in economic analyses. We compared baseline values of three HUs including Short ...

    Authors: Dennis W Raisch, Patricia Feeney, David C Goff Jr, KM Venkat Narayan, Patrick J O’Connor, Ping Zhang, Don G Hire and Mark D Sullivan
    Citation: Cardiovascular Diabetology 2012 11:35
    Content type: Original investigation Published on:

  13. Since betaine is an osmolyte and methyl donor, and abnormal betaine loss is common in diabetes mellitus (>20% patients), we investigated the relationship between betaine and the post-methionine load rise in ho...

    Authors: Michael Lever, Sandy Slow, David O McGregor, Warwick J Dellow, Peter M George and Stephen T Chambers
    Citation: Cardiovascular Diabetology 2012 11:34
    Content type: Original investigation Published on:

  14. A higher increase in intracellular Na+ via Na+/H+ exchanger (NHE) during ischemia has been reported in type 2 diabetic mouse hearts. We investigated the role of NHE in inducing changes in cytoplasmic Ca2+ concent...

    Authors: Ryuko Anzawa, Shingo Seki, Tomohisa Nagoshi, Ikuo Taniguchi, Danielle Feuvray and Michihiro Yoshimura
    Citation: Cardiovascular Diabetology 2012 11:33
    Content type: Original investigation Published on:

  15. Hypertension has a major associated risk for organ damage and mortality, which is further heightened in patients with prior cardiovascular (CV) events, comorbid diabetes mellitus, microalbuminuria and renal im...

    Authors: Samir G Mallat
    Citation: Cardiovascular Diabetology 2012 11:32
    Content type: Review Published on:

  16. The metabolic syndrome is associated with increased risk for both diabetes and coronary artery disease, which insulin resistance alone does not satisfactorily explain. We propose an additional and complementar...

    Authors: Surujpal Teelucksingh, Sarada Jaimungal, Lexley Pinto Pereira, Terence Seemungal and Shivananda Nayak
    Citation: Cardiovascular Diabetology 2012 11:31
    Content type: Original investigation Published on:

  17. Indigenous populations of Australia and Canada experience disproportionately high rates of chronic disease. Our goal was to compare cardiovascular (CVD) risk profile and diabetes complications from three recen...

    Authors: Louise J Maple-Brown, Joan Cunningham, Bernard Zinman, Mary Mamakeesick, Stewart B Harris, Philip W Connelly, Jonathan Shaw, Kerin O'Dea and Anthony J Hanley
    Citation: Cardiovascular Diabetology 2012 11:30
    Content type: Original investigation Published on:

  18. The hypoglycemic effect of bezafibrate is well established, but administration to a large population of patients with diabetes has not been reported. We investigated glycemic control, relationship between lipi...

    Authors: Tamio Teramoto, Kohji Shirai, Hiroyuki Daida and Nobuhiro Yamada
    Citation: Cardiovascular Diabetology 2012 11:29
    Content type: Original investigation Published on:

  19. The current study was carried out to determine whether fasudil hydrochloride (fasudil), a Rho-kinase inhibitor, has myocardial postconditioning (PostC) activity under hyperglycemia as well as normoglycemia, an...

    Authors: Taiga Ichinomiya, Sungsam Cho, Ushio Higashijima, Shuhei Matsumoto, Takuji Maekawa and Koji Sumikawa
    Citation: Cardiovascular Diabetology 2012 11:28
    Content type: Original investigation Published on:

  20. The leading cause of death for patients suffering from diabetes is macrovascular disease. Endothelial dysfunction is often observed in type 2 diabetic patients and it is considered to be an important early eve...

    Authors: Linnéa Eriksson, Özlem Erdogdu, Thomas Nyström, Qimin Zhang and Åke Sjöholm
    Citation: Cardiovascular Diabetology 2012 11:27
    Content type: Original investigation Published on:

  21. Chronic kidney disease (CKD) is associated with cardiovascular events. Adipocyte fatty acid-binding protein (A-FABP) plays an important role in atherosclerosis. We investigated whether plasma A-FABP is involve...

    Authors: Mutsumi Iwamoto, Toru Miyoshi, Masayuki Doi, Ko Takeda, Masahito Kajiya, Kazumasa Nosaka, Rie Nakayama, Satoshi Hirohata, Shinichi Usui, Shozo Kusachi, Kosuke Sakane, Kazuhfumi Nakamura and Hiroshi Ito
    Citation: Cardiovascular Diabetology 2012 11:26
    Content type: Original investigation Published on:

  22. People with central obesity have an increased risk for developing the metabolic syndrome, type 2 diabetes and cardiovascular disease. However, a substantial part of obese individuals have no other cardiovascul...

    Authors: Corine den Engelsen, Paula S Koekkoek, Kees J Gorter, Maureen van den Donk, Philippe L Salomé and Guy E Rutten
    Citation: Cardiovascular Diabetology 2012 11:25
    Content type: Original investigation Published on:

  23. Cardiac autonomic neuropathy (CAN) is a common complication of diabetes associated with poor prognosis. In addition, the autonomic imbalance is associated with cardiovascular disease (CVD) in diabetes. It is t...

    Authors: Chan-Hee Jung, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang, Sang-Hee Jung and Ji-Oh Mok
    Citation: Cardiovascular Diabetology 2012 11:24
    Content type: Original investigation Published on:

  24. Premature ventricular complexes (PVC) predict cardiovascular mortality among several adult populations. Increased arrhythmia prevalence has been reported during controlled magnesium (Mg) depletion studies in a...

    Authors: Liana C Del Gobbo, Yiqing Song, Paul Poirier, Eric Dewailly, Ronald J Elin and Grace M Egeland
    Citation: Cardiovascular Diabetology 2012 11:23
    Content type: Original investigation Published on:

  25. B-type natriuretic peptide (BNP), a member of the natriuretic peptide family, is a cardiac-derived secretory hormone with natriuretic, diuretic, and vasorelaxant activities. Intraabdominal fat accumulation is ...

    Authors: Hideaki Nakatsuji, Ken Kishida, Tohru Funahashi, Tohru Nakagawa and Iichiro Shimomura
    Citation: Cardiovascular Diabetology 2012 11:22
    Content type: Original investigation Published on:

  26. Meta-analysis has demonstrated an exponential relationship between 2-hr postchallenge hyperglycemia and coronary artery disease (CAD). Pulsatile hyperglycemia can acutely increase proinflammatory cytokines by ...

    Authors: Chih-Sheng Chu, Kun-Tai Lee, Kai-Hong Cheng, Min-Yi Lee, Hsuan-Fu Kuo, Tsung-Hsien Lin, Ho-Ming Su, Wen-Chol Voon, Sheng-Hsiung Sheu and Wen-Ter Lai
    Citation: Cardiovascular Diabetology 2012 11:21
    Content type: Original investigation Published on:

  27. Visceral adiposity index (VAI) has recently been suggested to be used as a surrogate of visceral adiposity. We examined if VAI could improve predictive performances for CVD of the Framingham's general CVD algo...

    Authors: Bozorgmanesh Mohammadreza, Hadaegh Farzad, Khalili Davoud and Azizi Fereidoun Prof
    Citation: Cardiovascular Diabetology 2012 11:20
    Content type: Original investigation Published on:

  28. Intensive multifactorial treatment aimed at prevention of cardiovascular (CV) disease may reduce left ventricular (LV) echocardiographic abnormalities in diabetic subjects. Plasma N-terminal (NT)-proBNP predic...

    Authors: Henrik Reinhard, Peter R Hansen, Niels Wiinberg, Andreas Kjær, Claus L Petersen, Kaj Winther, Hans-Henrik Parving, Peter Rossing and Peter K Jacobsen
    Citation: Cardiovascular Diabetology 2012 11:19
    Content type: Original investigation Published on:

  29. Lower extremity amputations are costly and debilitating complications in patients with diabetes mellitus (DM). Our aim was to investigate changes in the amputation rate in patients with DM at the Karolinska Un...

    Authors: Alexandra Alvarsson, Buster Sandgren, Carl Wendel, Michael Alvarsson and Kerstin Brismar
    Citation: Cardiovascular Diabetology 2012 11:18
    Content type: Original investigation Published on:

  30. The purpose of this study was to assess the efficacy of interventional therapy for peripheral arterial occlusive disease and the difference between diabetic patients and non-diabetic patients.

    Authors: Liang Xiao, De-sheng Huang, Jia-jie Tong and Jing Shen
    Citation: Cardiovascular Diabetology 2012 11:17
    Content type: Original investigation Published on:

  31. People of different racial and ethnic backgrounds have a distinct pattern of central fat deposition, thus making it necessary to devise a race based approach for the diagnosis and evaluation of abdominal obesi...

    Authors: Aibek E Mirrakhimov, Olga S Lunegova, Alina S Kerimkulova, Cholpon B Moldokeeva, Malik P Nabiev and Erkin M Mirrakhimov
    Citation: Cardiovascular Diabetology 2012 11:16
    Content type: Original investigation Published on:

  32. Generalized arterial alterations, such as endothelial dysfunction, medial matrix accumulations, and calcifications are associated with type 2 diabetes (T2D). These changes may render the vessel wall more susce...

    Authors: Vibe Skov, Steen Knudsen, Malene Olesen, Maria L Hansen and Lars M Rasmussen
    Citation: Cardiovascular Diabetology 2012 11:15
    Content type: Original investigation Published on:

  33. The prognostic benefits of beta-blockers (BB) in patients with systolic heart failure (SHF) are known but despite this, in patients with diabetes they are underutilized. The aim of this study was to assess the...

    Authors: Bryan Wai, Leighton G Kearney, David L Hare, Michelle Ord, Louise M Burrell and Piyush M Srivastava
    Citation: Cardiovascular Diabetology 2012 11:14
    Content type: Original investigation Published on:

  34. The aim of this study is to investigate the relationships between HbA1c and other risk factors like obesity, functional fitness, lipid profile, and inflammatory status in older adults. Epidemiological evidence...

    Authors: Raul A Martins, John G Jones, Sean P Cumming, Manuel J Coelho e Silva, Ana M Teixeira and Manuel T Veríssimo
    Citation: Cardiovascular Diabetology 2012 11:13
    Content type: Original investigation Published on:

  35. The decrease and dysfunction of endothelial progenitor cells (EPCs) has been assumed as an important cause/consequence of diabetes mellitus (DM) and its complications, in which the senescence of EPCs induced b...

    Authors: Zhiyong Yin, Linni Fan, Gaosheng Huang, Haichang Wang and Zhe Wang
    Citation: Cardiovascular Diabetology 2012 11:12
    Content type: Hypothesis Published on:

  36. Lipocalin-2 is a novel adipokine with connection to insulin resistance. In this study, we aimed to investigate the association of serum lipocalin-2 with glucose metabolism and other metabolic phenotype in a la...

    Authors: Ying Huang, Zhen Yang, Zi Ye, Qin Li, Jie Wen, Xiaoming Tao, Lili Chen, Min He, Xuanchun Wang, Bin Lu, Zhaoyun Zhang, Weiwei Zhang, Shen Qu and Renming Hu
    Citation: Cardiovascular Diabetology 2012 11:11
    Content type: Original investigation Published on:

  37. The role of Lipoprotein (a) cholesterol {Lp(a)-C}as an additional and/or independent risk factor for cardiovascular disease (CVD) is not clear. We evaluated the associations between Lp(a)-C and other CVD risk ...

    Authors: Sushma Sharma, Jayshree Merchant and Sharon E Fleming
    Citation: Cardiovascular Diabetology 2012 11:10
    Content type: Original investigation Published on:

  39. An impairment of cardiovascular function in streptozotocin (STZ)-diabetic rats has been mentioned within 5 days-to-3 months of induction. ATP-sensitive potassium (KATP) channels are expressed on cardiac sarcolemm...

    Authors: Zhih-Cherng Chen, Yung-Ze Cheng, Li-Jen Chen, Kai-Chun Cheng, Yin- Xiao Li and Juei- Tang Cheng
    Citation: Cardiovascular Diabetology 2012 11:8
    Content type: Original investigation Published on:

  40. The role of advanced glycation end products (AGEs) in the development of diabetes, especially diabetic complications, has been emphasized in many reports. Accumulation of AGEs in the vasculature triggers a ser...

    Authors: Jiping Wang, Hongxia Liu, Bo Chen, Qiang Li, Xuliang Huang, Liqun Wang, Xiaohua Guo and Qiaobing Huang
    Citation: Cardiovascular Diabetology 2012 11:7
    Content type: Original investigation Published on:

  42. Adiposity greatly increases the risk of atherothrombotic events, a pathological condition where a chronic state of oxidative stress is reported to play a major role. This study aimed to investigate the involve...

    Authors: Priscila F Monteiro, Rafael P Morganti, Maria A Delbin, Marina C Calixto, Maria E Lopes-Pires, Sisi Marcondes, Angelina Zanesco and Edson Antunes
    Citation: Cardiovascular Diabetology 2012 11:5
    Content type: Original investigation Published on:

  43. The authors examined whether milrinone and levosimendan could exert cardiac postconditioning effects in rats under normoglycemia and hyperglycemia, and whether the effects could be mediated by mitochondrial pe...

    Authors: Shuhei Matsumoto, Sungsam Cho, Shinya Tosaka, Ushio Higashijima, Takuji Maekawa, Tetsuya Hara and Koji Sumikawa
    Citation: Cardiovascular Diabetology 2012 11:4
    Content type: Original investigation Published on:

  44. This study investigated the cardiovascular (CV) safety profile of the dipeptidyl peptidase (DPP)-4 inhibitor linagliptin versus comparator treatments.

    Authors: Odd Erik Johansen, Dietmar Neubacher, Maximilian von Eynatten, Sanjay Patel and Hans-Juergen Woerle
    Citation: Cardiovascular Diabetology 2012 11:3
    Content type: Original investigation Published on:

  45. Carotid intima-media thickness (IMT) is an useful surrogate marker of cardiovascular disease. Associations between uric acid (UA), metabolic syndrome (MetS) and carotid IMT have been reported, but findings reg...

    Authors: Shuzo Takayama, Ryuichi Kawamoto, Tomo Kusunoki, Masanori Abe and Morikazu Onji
    Citation: Cardiovascular Diabetology 2012 11:2
    Content type: Original investigation Published on:

  46. Previous randomized controlled trials demonstrated a protective effect of renin angiotensin system blocking agents for the development of type-2 diabetes in patients with pre-diabetes. However, there are no re...

    Authors: Walter Zidek, Joachim Schrader, Stephan Lüders, Stephan Matthaei, Christoph Hasslacher, Joachim Hoyer, Claudia Zemmrich, Peter Bramlage, Claus-Dieter Sturm and W Dieter Paar
    Citation: Cardiovascular Diabetology 2012 11:1
    Content type: Original investigation Published on:

  47. The increased risk of cardiovascular disease (CVD) in diabetic compared to non-diabetic subjects seems to decrease with age. Whether this age-related reduction applies to CVD risk factors, and whether it is li...

    Authors: Margret Leosdottir, Ronnie Willenheimer, Margaretha Persson and Peter M Nilsson
    Citation: Cardiovascular Diabetology 2011 10:118
    Content type: Original investigation Published on:

  48. Type 2 diabetes mellitus (T2DM) is associated with an increased risk of atherosclerotic vascular disease, but it is unknown whether the other way around is true too. C57BL/6 (B6) and BALB/cJ (BALB) are two mou...

    Authors: Jing Li, Qian Wang, Weidong Chai, Mei-Hua Chen, Zhenqi Liu and Weibin Shi
    Citation: Cardiovascular Diabetology 2011 10:117
    Content type: Original investigation Published on:

  49. This study investigates the associations between changes in serum Triglycerides (S-TG), -Urate (S-Urate), and -Glucose (S-Glu) and changes in serum Calcium (S-Ca), -Magnesium (S-Mg), and -Phosphate (S-P) in pa...

    Authors: Lena Håglin, Lennart Bäckman and Birgitta Törnkvist
    Citation: Cardiovascular Diabetology 2011 10:116
    Content type: Original investigation Published on:

  50. Glucose fluctuations including robust postprandial hyperglycemia are a risk for promoting atherosclerosis and diabetic complications. The α-glucosidase inhibitors and the dipeptidyl peptidase-4 (DPP-4) inhibit...

    Authors: Miyako Kishimoto and Mitsuhiko Noda
    Citation: Cardiovascular Diabetology 2011 10:115
    Content type: Original investigation Published on:
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