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  1. Obesity is a major risk factor for development and progression of hypertension and diabetes, which often coexist in obese patients. Losing weight by means of energy restriction and physical activity has been e...

    Authors: Guixiang Zhao, Earl S Ford, Chaoyang Li and Ali H Mokdad
    Citation: Cardiovascular Diabetology 2009 8:13
  2. Poor control of type 2 diabetes results in substantial long-term consequences. Studies of new diabetes treatments are rarely designed to assess mortality, complication rates and costs. We sought to estimate th...

    Authors: Sean D Sullivan, Rafael Alfonso-Cristancho, Chris Conner, Mette Hammer and Lawrence Blonde
    Citation: Cardiovascular Diabetology 2009 8:12
  3. The renin-angiotensin aldosterone system (RAAS) plays an important role in regulating the blood pressure and the genetic polymorphisms of RAAS genes has been extensively studied in relation to the cardiovascul...

    Authors: Vasudevan Ramachandran, Patimah Ismail, Johnson Stanslas and Norashikin Shamsudin
    Citation: Cardiovascular Diabetology 2009 8:11
  4. Inflammation contributes to cardiovascular complications in type 2 diabetes, which are often characterized by microvascular alterations. We investigated whether myeloid-related protein 8/14 complex (MRP8/14) s...

    Authors: Klaus Burkhardt, Sonja Schwarz, Chengrui Pan, Felix Stelter, Konstantin Kotliar, Maxilian Von Eynatten, Daniel Sollinger, Ines Lanzl, Uwe Heemann and Marcus Baumann
    Citation: Cardiovascular Diabetology 2009 8:10
  5. Insulin glargine (glargine) and premixed insulins (premix) are alternative insulin treatments. This analysis evaluated glycaemic control in 528 patients with type 1 (n = 183) or type 2 (n = 345) diabetes, afte...

    Authors: Peter Sharplin, Jason Gordon, John R Peters, Anthony P Tetlow, Andrea J Longman and Philip McEwan
    Citation: Cardiovascular Diabetology 2009 8:9
  6. High glucose could induce structure and function change in cardiomyocytes, PKC plays a core effect in the onset and progression of diabetic cardiomyopathy, but its underlying downstream signal transduction pat...

    Authors: Wang Min, Zhang Wen Bin, Zhou Bin Quan, Zhu Jun Hui and Fu Guo Sheng
    Citation: Cardiovascular Diabetology 2009 8:8
  7. The prevalence of vitamin D insufficiency and secondary hyperparathyroidism is high among morbidly obese subjects. Further, low serum levels of 25-hydroxyvitamin D (25 [OH]D) and magnesium have been associated...

    Authors: Jøran Hjelmesæth, Dag Hofsø, Erlend T Aasheim, Trond Jenssen, Johan Moan, Helle Hager, Jo Røislien and Jens Bollerslev
    Citation: Cardiovascular Diabetology 2009 8:7
  8. A high prevalence of impaired glucose tolerance and unknown type 2-diabetes in patients with coronary heart disease and no previous diagnosis of diabetes have been reported. The aims of the present study were ...

    Authors: Eva C Knudsen, Ingebjørg Seljeflot, Michael Abdelnoor, Jan Eritsland, Arild Mangschau, Harald Arnesen and Geir Ø Andersen
    Citation: Cardiovascular Diabetology 2009 8:6
  9. The effects of pan-peroxisome proliferator-activated receptor (PPAR) ligand bezafibrate on N-terminal pro-B type natriuretic peptide (ProBNP) level in patients with coronary artery disease (CAD) is unknown. Th...

    Authors: Koichi Node, Teruo Inoue, Valentin Boyko, Ilan Goldberg, Enrique Z Fisman, Yehuda Adler, Ehud Schwammenthal, Zipora Matas, Solomon Behar and Alexander Tenenbaum
    Citation: Cardiovascular Diabetology 2009 8:5
  10. Poor control of blood glucose in diabetes is known to promote vascular dysfunction and hypertension. Diabetes was recently shown to be linked to an increased prevalence of pulmonary hypertension. The aim of th...

    Authors: Alison M Gurney and Frank C Howarth
    Citation: Cardiovascular Diabetology 2009 8:4
  11. Insulin glargine (glargine) and insulin NPH (NPH) are two basal insulin treatments. This study investigated the effect on glycaemic control of switching from a NPH-based regimen to a glargine-based regimen in ...

    Authors: Peter Sharplin, Jason Gordon, John R Peters, Anthony P Tetlow, Andrea J Longman and Philip McEwan
    Citation: Cardiovascular Diabetology 2009 8:3
  12. Differences in prevalence of cardiometabolic risk factors between different ethnic groups are largely unknown. We determined the variation in cardiometabolic risk profile according to ethnicity in a cohort ove...

    Authors: Mariska van Vliet, Inès A von Rosenstiel, Roger K Schindhelm, Desiderius PM Brandjes, Jos H Beijnen and Michaela Diamant
    Citation: Cardiovascular Diabetology 2009 8:2
  13. Mixed hyperlipidemia is common in patients with diabetes. Statins, the choice drugs, are effective at reducing lipoproteins that contain apolipoprotein B100, but they fail to exert good control over intestinal...

    Authors: Pedro Valdivielso, José Rioja, Carlota García-Arias, Miguel Angel Sánchez-Chaparro and Pedro González-Santos
    Citation: Cardiovascular Diabetology 2009 8:1
  14. The use of abciximab (c7E3 Fab) or eptifibatide improves clinical outcomes in diabetics undergoing percutaneous coronary intervention. These β3 integrin inhibitors antagonize fibrinogen binding to αIIbβ3 integrin...

    Authors: Alokkumar Pathak, Renyi Zhao, Jianhua Huang and George A Stouffer
    Citation: Cardiovascular Diabetology 2008 7:36
  15. Several aspects concerning the relationship between the metabolic syndrome and incident diabetes are incompletely understood including the magnitude of the risk estimate, potential gender differences in the as...

    Authors: Earl S Ford, Matthias B Schulze, Tobias Pischon, Manuela M Bergmann, Hans-Georg Joost and Heiner Boeing
    Citation: Cardiovascular Diabetology 2008 7:35
  16. Different mechanisms of diabetic-induced NO dysfunction have been proposed and central to most of them are significant changes in eNOS function as the rate-limiting step in NO bioavailability. eNOS exists in b...

    Authors: James Grijalva, Steven Hicks, Xiangmin Zhao, Sushma Medikayala, Pawel M Kaminski, Michael S Wolin and John G Edwards
    Citation: Cardiovascular Diabetology 2008 7:34
  17. We investigated the role of polyol pathway enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH) in mediating injury due to ischemia-reperfusion (IR) in Type 2 diabetic BBZ rat hearts. Specifically, w...

    Authors: Qing Li, Yuying C Hwang, Radha Ananthakrishnan, Peter J Oates, Dennis Guberski and Ravichandran Ramasamy
    Citation: Cardiovascular Diabetology 2008 7:33
  18. In Sweden, diabetes prevalence is increasing in spite of unchanged incidence, indicating improved survival. In recent US studies mortality in diabetic subjects has decreased over three decades, but only in men...

    Authors: Mats Eliasson, Mats Talbäck and Måns Rosén
    Citation: Cardiovascular Diabetology 2008 7:32
  19. Current guidelines from the European Society of Cardiology (ESC) define low thresholds for the diagnosis of dyslipidemia using total cholesterol (TC) and LDL-cholesterol (LDL-C) to guide treatment. Although be...

    Authors: Elisabeth Steinhagen-Thiessen, Peter Bramlage, Christian Lösch, Hans Hauner, Heribert Schunkert, Anja Vogt, Jürgen Wasem, Karl-Heinz Jöckel and Susanne Moebus
    Citation: Cardiovascular Diabetology 2008 7:31
  20. Cardiovascular disease is the major cause of morbidity and mortality associated with diabetes. There is increasing evidence that advanced glycation endproducts (AGEs) play a pivotal role in atherosclerosis, in...

    Authors: Robbert Meerwaldt, Thera Links, Clark Zeebregts, Rene Tio, Jan-Luuk Hillebrands and Andries Smit
    Citation: Cardiovascular Diabetology 2008 7:29
  21. We examined, in a country of the African region, i) the prevalence of the metabolic syndrome (MetS) according to three definitions (ATP, WHO and IDF); ii) the distribution of the MetS criteria; iii) the level ...

    Authors: Clara Kelliny, Julita William, Walter Riesen, Fred Paccaud and Pascal Bovet
    Citation: Cardiovascular Diabetology 2008 7:27
  22. The role of structural and functional abnormalities of small vessels in diabetes cardiomyopathy remains unclear. Myocardial contrast echocardiography allows the quantification of myocardial blood flow at rest ...

    Authors: Bernard Cosyns, Steven Droogmans, Sophie Hernot, Céline Degaillier, Christian Garbar, Caroline Weytjens, Bram Roosens, Danny Schoors, Tony Lahoutte, Philippe R Franken and Guy Van Camp
    Citation: Cardiovascular Diabetology 2008 7:26
  23. Anaemia has been shown in previous studies to be a risk factor for cardiovascular disease in diabetic patients with chronic kidney disorder. This study was aimed to assess the prevalence of anaemia and kidney ...

    Authors: Chidum E Ezenwaka, Altheia Jones-LeCointe, Emeka Nwagbara, Dawn Seales and Fidelis Okali
    Citation: Cardiovascular Diabetology 2008 7:25
  24. Exenatide belongs to a new therapeutic class in the treatment of diabetes (incretin mimetics), allowing glucose-dependent glycaemic control in Type 2 diabetes. Randomised controlled trial data suggest that exe...

    Authors: Anette Woehl, Mark Evans, Anthony P Tetlow and Philip McEwan
    Citation: Cardiovascular Diabetology 2008 7:24
  25. Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed.

    Authors: María E Sáez, Antonio Grilo, Francisco J Morón, Luis Manzano, María T Martínez-Larrad, Antonio González-Pérez, Javier Serrano-Hernando, Agustín Ruiz, Reposo Ramírez-Lorca and Manuel Serrano-Ríos
    Citation: Cardiovascular Diabetology 2008 7:23
  26. Recent clinical trials reported conflicting results on the reduction of new-onset diabetes using RAS blocking agents. Therefore the role of these agents in preventing diabetes is still not well defined. Ramipr...

    Authors: Walter Zidek, Joachim Schrader, Stephan Lüders, Stephan Matthaei, Christoph Hasslacher, Joachim Hoyer, Peter Bramlage, Claus-Dieter Sturm and W Dieter Paar
    Citation: Cardiovascular Diabetology 2008 7:22
  27. There is currently much interest in encouraging individuals to increase physical activity in order to reduce CVD risk. This study has been designed to determine if personalised CVD risk appreciation can increa...

    Authors: Hermione C Price, Lynne Tucker, Simon J Griffin and Rury R Holman
    Citation: Cardiovascular Diabetology 2008 7:21
  28. The metabolic deregulation associated with diabetes mellitus (DM) causes secondary pathophysiologic changes in multiple organ systems. Endothelial injury is induced by oxidative stress (OS) and inflammation. W...

    Authors: Raymond Farah, Revital Shurtz-Swirski and Olga Lapin
    Citation: Cardiovascular Diabetology 2008 7:20
  29. Epidemiologic studies have suggested that hypertriglyceridemia and insulin resistance are related to the development of colon cancer. Nuclear peroxisome proliferator-activated receptors (PPAR), which play a ce...

    Authors: Alexander Tenenbaum, Valentina Boyko, Enrique Z Fisman, Ilan Goldenberg, Yehuda Adler, Micha S Feinberg, Michael Motro, David Tanne, Joseph Shemesh, Ehud Schwammenthal and Solomon Behar
    Citation: Cardiovascular Diabetology 2008 7:18
  30. The large clinical trials proved that Basal-Bolus (BB) insulin therapy was effective in the prevention of diabetic complications and their progression. However, BB therapy needs multiple insulin injections per...

    Authors: Yumi Miyashita, Rimei Nishimura, Masami Nemoto, Toru Matsudaira, Hideaki Kurata, Tamotsu Yokota, Kuninobu Yokota, Katsuyoshi Tojo, Kazunori Utsunomiya and Naoko Tajima
    Citation: Cardiovascular Diabetology 2008 7:16
  31. In comparison to the well established changes in compliance that occur at the large vessel level in diabetes, much less is known about the changes in compliance of the cardiovascular system at the end-organ le...

    Authors: Richard J MacIsaac, Merlin C Thomas, Sianna Panagiotopoulos, Trudy J Smith, Huming Hao, D Geoffrey Matthews, George Jerums, Louise M Burrell and Piyush M Srivastava
    Citation: Cardiovascular Diabetology 2008 7:15
  32. Epidemiological studies have revealed a relationship between early growth restriction and the subsequent development of insulin resistance and type 2 diabetes. Ligation of the uterine arteries in rats mimics u...

    Authors: Daniela Germani, Antonella Puglianiello and Stefano Cianfarani
    Citation: Cardiovascular Diabetology 2008 7:14
  33. Diabetes has negative, and exercise training positive, effects on the skeletal muscle vasculature, but the mechanisms are not yet fully understood. In the present experiment the effects of running exercise on ...

    Authors: Riikka Kivelä, Mika Silvennoinen, Maarit Lehti, Sanni Jalava, Veikko Vihko and Heikki Kainulainen
    Citation: Cardiovascular Diabetology 2008 7:13
  34. Hypertension and type 2 diabetes are common co-morbidities. Preliminary studies suggest that thiazolidinediones reduce blood pressure (BP). We therefore used ambulatory BP to quantify BP lowering at 6–12 month...

    Authors: Michel Komajda, Paula Curtis, Markolf Hanefeld, Henning Beck-Nielsen, Stuart J Pocock, Andrew Zambanini, Nigel P Jones, Ramon Gomis and Philip D Home
    Citation: Cardiovascular Diabetology 2008 7:10
  35. There are no risk scores available for predicting heart failure in Type 2 diabetes mellitus (T2DM). Based on the Hong Kong Diabetes Registry, this study aimed to develop and validate a risk score for predictin...

    Authors: Xilin Yang, Ronald C Ma, Wing-Yee So, Alice P Kong, Gary T Ko, Chun-Shun Ho, Christopher W Lam, Clive S Cockram, Peter C Tong and Juliana C Chan
    Citation: Cardiovascular Diabetology 2008 7:9
  36. An authentic survey of the transcript-level response of the diabetic endothelium in vivo is key to understanding diabetic cardiovascular complications such as accelerated atherosclerosis and endothelial dysfun...

    Authors: J Gregory Maresh and Ralph V Shohet
    Citation: Cardiovascular Diabetology 2008 7:8
  37. The rs9939609 T>A single-nucleotide polymorphism (SNP) in the FTO gene has previously been found to be associated with obesity in European Caucasian samples. The objective of this study is to examine whether this...

    Authors: Salam A Al-Attar, Rebecca L Pollex, Matthew R Ban, T Kue Young, Peter Bjerregaard, Sonia S Anand, Salim Yusuf, Bernard Zinman, Stewart B Harris, Anthony JG Hanley, Philip W Connelly, Murray W Huff and Robert A Hegele
    Citation: Cardiovascular Diabetology 2008 7:5
  38. The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been reported to be as closely correlated with insulin resistance as is the fasting serum insulin concentration (FSI), and therefor...

    Authors: Chaoyang Li, Earl S Ford, Yuan-Xiang Meng, Ali H Mokdad and Gerald M Reaven
    Citation: Cardiovascular Diabetology 2008 7:4
  39. Thiazolidinediones exert anti-inflammatory and anti-oxidative roles and attenuate atherosclerosis by mechanisms partially independent of their metabolizing actions. High doses of angiotensin type 1 receptor (AT1R...

    Authors: Y Hernandez-Trujillo, F Rodriguez-Esparragon, A Macias-Reyes, A Caballero-Hidalgo and Jose C Rodriguez-Perez
    Citation: Cardiovascular Diabetology 2008 7:3
  40. Activation of the diacylglycerol (DAG)-protein kinase C (PKC) pathway has been implicated in the pathogenesis of a number of diabetic complications. Diacylglycerol kinase (DGK) converts DAG to phosphatidic aci...

    Authors: Olga Bilim, Yasuchika Takeishi, Tatsuro Kitahara, Takanori Arimoto, Takeshi Niizeki, Toshiki Sasaki, Kaoru Goto and Isao Kubota
    Citation: Cardiovascular Diabetology 2008 7:2
  41. Aortic distensibility (AD) is a marker of the elastic properties of the aorta. Reduction of AD occurs early in subjects with type 2 diabetes mellitus (T2DM) and it is associated with subclinical generalized at...

    Authors: Nicholas Tentolouris, Athanasia Papazafiropoulou, Ioannis Moyssakis, Stavros Liatis, Despoina Perrea, Maria Kostakis and Nicholas Katsilambros
    Citation: Cardiovascular Diabetology 2008 7:1
  42. Intensive insulin therapy to maintain normoglycemia after cardiac surgery reduces morbidity and mortality. We investigated the magnitude and duration of hyperglycemia caused by dexamethasone administered after...

    Authors: Mathijs Vogelzang, Miriam Hoekstra, José T Drost, Marcel Janse, Iwan CC van der Horst, Piet W Boonstra, Felix Zijlstra, Bert G Loef and Maarten WN Nijsten
    Citation: Cardiovascular Diabetology 2007 6:39

Cardiovascular Diabetology is affiliated with Sackler Faculty of Medicine, Tel-Aviv University

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