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  1. Gliptins should have beneficial effects beyond glycemic control, potentially on the pathophysiology of cardiovascular (CV) diseases, with some basic studies demonstrating this possibility. However, we are yet ...

    Authors: Takashi Nakamura, Yoshitaka Iwanaga, Yuki Miyaji, Ryuji Nohara, Takao Ishimura and Shunichi Miyazaki
    Citation: Cardiovascular Diabetology 2016 15:54
    Content type: Original investigation Published on:

  2. Oxidative stress, inflammation and endothelial dysfunction are interrelated factors in the etiology of cardiovascular disease, but their linkage to type 2 diabetes is less clear. We examined the association of...

    Authors: Andrew O. Odegaard, David R. Jacobs Jr., Otto A. Sanchez, David C. Goff Jr., Alexander P. Reiner and Myron D. Gross
    Citation: Cardiovascular Diabetology 2016 15:51
    Content type: Original investigation Published on:

  3. The mechanisms leading to the high on-treatment platelet reactivity in diabetes patients are not fully elucidated. The genetic factors may be associated with the diminished antiplatelet efficacy of dual antipl...

    Authors: Dingyu Zhang, Xiaolin Zhang, Dan Liu, Tengfei Liu, Wenzhi Cai, Chenghui Yan and Yaling Han
    Citation: Cardiovascular Diabetology 2016 15:50
    Content type: Original Investigation Published on:

  4. Circulating microRNAs (miRs) are differentially regulated and selectively packaged into microparticles (MPs). We evaluated whether diabetes mellitus alters circulating vascular and endothelial MP-incorporated ...

    Authors: Felix Jansen, Han Wang, David Przybilla, Bernardo S. Franklin, Andreas Dolf, Philipp Pfeifer, Theresa Schmitz, Anna Flender, Elmar Endl, Georg Nickenig and Nikos Werner
    Citation: Cardiovascular Diabetology 2016 15:49
    Content type: Original investigation Published on:

  5. Heart failure (HF), especially with preserved ejection fraction (HFpEF) is common in older patients with type 2 diabetes (T2DM), but often not recognized. Early HF detection in older T2DM patients may be worth...

    Authors: Anoukh van Giessen, Leandra J. M. Boonman-de Winter, Frans H. Rutten, Maarten J. Cramer, Marcel J. Landman, Anho H. Liem, Arno W. Hoes and Hendrik Koffijberg
    Citation: Cardiovascular Diabetology 2016 15:48
    Content type: Original investigation Published on:

  6. Questions remain as to the association between essential hypertension and increased incidence of type 2 diabetes (T2DM). The premise of this analysis is that insulin resistance/compensatory hyperinsulinemia is...

    Authors: Ki-Chul Sung, Hyun-Young Park, Min-Ju Kim and Gerald Reaven
    Citation: Cardiovascular Diabetology 2016 15:47
    Content type: Original investigation Published on:

  7. Hyperglycemia and increased levels of methylglyoxal (MGO) can trigger the development of vascular complications in diabetes. Resveratrol and quercetin are red wine polyphenols with known beneficial cardiovascu...

    Authors: Charlotte Boydens, Bart Pauwels, Laura Vanden Daele and Johan Van de Voorde
    Citation: Cardiovascular Diabetology 2016 15:46
    Content type: Original Investigation Published on:

  8. Reduced heart rate variability (HRV), a measure of cardiac autonomic function, is associated with an increased risk of cardiovascular disease (CVD) and mortality. Glucose homeostasis measures are associated wi...

    Authors: Michelle L. Meyer, Nathan M. Gotman, Elsayed Z. Soliman, Eric A. Whitsel, Raanan Arens, Jianwen Cai, Martha L. Daviglus, Pablo Denes, Hector M. González, Juan Moreiras, Gregory A. Talavera and Gerardo Heiss
    Citation: Cardiovascular Diabetology 2016 15:45
    Content type: Original investigation Published on:

  9. Diabetic cardiomyopathy (DCM) is a disorder of the heart muscle in people with diabetes that can occur independent of hypertension or vascular disease. The underlying mechanism of DCM is incompletely understoo...

    Authors: Vidya Kandula, Ramoji Kosuru, Haobo Li, Dan Yan, Qiqi Zhu, Qingquan Lian, Ren-shan Ge, Zhengyuan Xia and Michael G. Irwin
    Citation: Cardiovascular Diabetology 2016 15:44
    Content type: Review Published on:

  10. Both carotid and lower limb atherosclerosis are associated with increased cardiovascular and cerebrovascular risks. However, it is still unclear whether the concomitant presence of carotid and lower extremity ...

    Authors: Mei-Fang Li, Cui-Chun Zhao, Ting-Ting Li, Yin-Fang Tu, Jun-Xi Lu, Rong Zhang, Ming-Yun Chen, Yu-Qian Bao, Lian-Xi Li and Wei-Ping Jia
    Citation: Cardiovascular Diabetology 2016 15:43
    Content type: Original investigation Published on:

  11. Previous studies have shown that high glucose (HG) induced endothelial cell (EC) damage via a phenotypic transition of EC. There is increasing evidence suggesting the role of inflammatory cytokines in mediated...

    Authors: Dong-Dong Zhu, Ri-Ning Tang, Lin-Li Lv, Yi Wen, Hong Liu, Xiao-Liang Zhang, Kun-Ling Ma and Bi-Cheng Liu
    Citation: Cardiovascular Diabetology 2016 15:42
    Content type: Original Investigation Published on:

  12. Several antidiabetic drugs (i.e., sulfonylureas; SU, rosiglitazone) have been reported to be associated with increased risks of cardiovascular diseases (CVD) in patients with type 2 diabetes mellitus (T2DM). D...

    Authors: Huang-Tz Ou, Kai-Cheng Chang, Chung-Yi Li and Jin-Shang Wu
    Citation: Cardiovascular Diabetology 2016 15:41
    Content type: Original article Published on:

  13. Soluble tumor necrosis factor receptors 1 and 2 (sTNFR1 and sTNFR2) contribute to experimental diabetic kidney disease, a condition with substantially increased cardiovascular risk when present in patients. Th...

    Authors: Axel C. Carlsson, Carl Johan Östgren, Fredrik H. Nystrom, Toste Länne, Pär Jennersjö, Anders Larsson and Johan Ärnlöv
    Citation: Cardiovascular Diabetology 2016 15:40
    Content type: Original investigation Published on:

  14. Aim of this retrospective study was to compare long-term mortality and incidence of new diseases [diabetes and cardiovascular (CV) disease] in morbidly obese diabetic and nondiabetic patients, undergoing gastr...

    Authors: Antonio E. Pontiroli, Ahmed S. Zakaria, Ermanno Mantegazza, Alberto Morabito, Alessandro Saibene, Enrico Mozzi and Giancarlo Micheletto
    Citation: Cardiovascular Diabetology 2016 15:39
    Content type: Original investigation Published on:

  15. Patients with type 2 diabetes (T2D) have a substantial increased risk for cardiovascular (CV) disease and associated mortality than those without diabetes. Dulaglutide is a once-weekly glucagon-like peptide-1 ...

    Authors: Keith C. Ferdinand, Fady T. Botros, Charles M. Atisso and Philip T. Sager
    Citation: Cardiovascular Diabetology 2016 15:38
    Content type: Original investigation Published on:

  16. A pre-specified meta-analysis of cardiovascular (CV) events from 21 phase 2b/3 dapagliflozin clinical trials was undertaken to characterise the CV profile of dapagliflozin. This showed no increase in CV risk w...

    Authors: Christian Sonesson, Peter A. Johansson, Eva Johnsson and Ingrid Gause-Nilsson
    Citation: Cardiovascular Diabetology 2016 15:37
    Content type: Original investigation Published on:

  17. Patients with angina-like symptoms without myocardial perfusion scintigram (MPS)-verified abnormality may still be at risk for cardiovascular events. We hypothesized that insulin resistance could play a role i...

    Authors: Helena U. Westergren, Sara Svedlund, Remi A. Momo, Juuso I. Blomster, Karin Wåhlander, Erika Rehnström, Peter J. Greasley, Regina Fritsche-Danielson, Jan Oscarsson and Li-Ming Gan
    Citation: Cardiovascular Diabetology 2016 15:36
    Content type: Original Investigation Published on:

  19. Diabetes mellitus (DM) is estimated to become the 7th leading cause of death by 2030. Right ventricular dysfunction (RVD) complicating ST elevation myocardial infarction (STEMI) is independently associated wit...

    Authors: Idan Roifman, Nilesh Ghugre, Mohammad I. Zia, Michael E. Farkouh, Anna Zavodni, Graham A. Wright and Kim A. Connelly
    Citation: Cardiovascular Diabetology 2016 15:34
    Content type: Original investigation Published on:

  20. The 1st Cardiovascular Outcome Trial (CVOT) Summit of the Diabetes & Cardiovascular Disease (D&CVD) EASD Study Group was held during the annual meeting on 30 October 2015 in Munich. This summit was organized i...

    Authors: Oliver Schnell, Eberhard Standl, Doina Catrinoiu, Stefano Genovese, Nebojsa Lalic, Jan Skra, Paul Valensi and Antonio Ceriello
    Citation: Cardiovascular Diabetology 2016 15:33
    Content type: Commentary Published on:

  21. Adenosine has been shown to induce nitric oxide (NO) production via inducible NO synthase (iNOS) activation in vascular smooth muscle cells (VSMCs). Although this is interpreted as a beneficial vasodilating pa...

    Authors: Alberto Nassi, Francesca Malorgio, Serena Tedesco, Andrea Cignarella and Rosa Maria Gaion
    Citation: Cardiovascular Diabetology 2016 15:32
    Content type: Original investigation Published on:

  22. Children with type 1 diabetes (T1D) are at higher risk of early adult-onset cardiovascular disease. We assessed cardiovascular structure and function in adolescents with T1D compared with healthy controls and ...

    Authors: Timothy J. Bradley, Cameron Slorach, Farid H. Mahmud, David B. Dunger, John Deanfield, Livia Deda, Yesmino Elia, Ronnie L. H. Har, Wei Hui, Rahim Moineddin, Heather N. Reich, James W. Scholey, Luc Mertens, Etienne Sochett and David Z. I. Cherney
    Citation: Cardiovascular Diabetology 2016 15:31
    Content type: Original Investigation Published on:

  23. Skin collagen Long Wavelength Fluorescence (LWF) is widely used as a surrogate marker for accumulation of advanced glycation end-products. Here we determined the relationship of LWF with glycemia, skin fluores...

    Authors: David R. Sell, Wanjie Sun, Xiaoyu Gao, Christopher Strauch, John M. Lachin, Patricia A. Cleary, Saul Genuth and Vincent M. Monnier
    Citation: Cardiovascular Diabetology 2016 15:30
    Content type: Original investigation Published on:

  24. Epidemiological data on obesity are needed, particularly in patients with type 2 diabetes mellitus (T2DM) and high cardiovascular (CV) risk. We used the baseline data of liraglutide effect and action in diabet...

    Authors: L. Masmiquel, L. A. Leiter, J. Vidal, S. Bain, J. Petrie, E. Franek, I. Raz, A. Comlekci, S. Jacob, L. van Gaal, F. M. M. Baeres, S. P. Marso and M. Eriksson
    Citation: Cardiovascular Diabetology 2016 15:29
    Content type: Original Investigation Published on:

  25. There is increasing evidence to suggest that not all individuals with type 2 diabetes mellitus (T2DM) have equal risk for developing cardiovascular disease. We sought to compare the yield of testing for pre-cl...

    Authors: Carlos Henrique Reis Esselin Rassi, Timothy W. Churchill, Carlos A. Fernandes Tavares, Mateus Guimaraes Fahel, Fabricia P. O. Rassi, Augusto H. Uchida, Bernardo L. Wajchenberg, Antonio C. Lerario, Edward Hulten, Khurram Nasir, Márcio S. Bittencourt, Carlos Eduardo Rochitte and Ron Blankstein
    Citation: Cardiovascular Diabetology 2016 15:28
    Content type: Original investigation Published on:

  26. Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with diabetes mellitus (DM). To identify the most effective treatment for CVD, it is paramount to understand the mechani...

    Authors: Sherin Bakhashab, Fahad W. Ahmed, Hans-Juergen Schulten, Ayat Bashir, Sajjad Karim, Abdulrahman L. Al-Malki, Mamdooh A. Gari, Adel M. Abuzenadah, Adeel G. Chaudhary, Mohammed H. Alqahtani, Sahira Lary, Farid Ahmed and Jolanta U. Weaver
    Citation: Cardiovascular Diabetology 2016 15:27
    Content type: Original investigation Published on:

  27. Diabetes is a risk factor for atherosclerosis associated with oxidative stress, inflammation and cell proliferation. The purpose of this study was to evaluate arterial choline uptake and its relationship to at...

    Authors: Sanna Hellberg, Johanna M. U. Silvola, Max Kiugel, Heidi Liljenbäck, Olli Metsälä, Tapio Viljanen, Jari Metso, Matti Jauhiainen, Pekka Saukko, Pirjo Nuutila, Seppo Ylä-Herttuala, Juhani Knuuti, Anne Roivainen and Antti Saraste
    Citation: Cardiovascular Diabetology 2016 15:26
    Content type: Original investigation Published on:

  28. ANGPTL8 also called betatrophin is a regulator of lipid metabolism through its interaction with ANGPTL3. It has also been suggested to play a role in insulin resistance and beta-cell proliferation. Based on it...

    Authors: Mohamed Abu-Farha, Jehad Abubaker, Irina Al-Khairi, Preethi Cherian, Fiona Noronha, Sina Kavalakatt, Abdelkrim Khadir, Kazem Behbehani, Monira Alarouj, Abdullah Bennakhi and Naser Elkum
    Citation: Cardiovascular Diabetology 2016 15:25
    Content type: Original investigation Published on:

  29. A novel MRI technique, employing dual contrast manganese-enhanced MRI (MEMRI) and delayed enhancement MRI (DEMRI), can evaluate the physiologically unstable peri-infarct region. Dual contrast MEMRI–DEMRI enab...

    Authors: Ildiko Toma, Paul J. Kim, Rajesh Dash, Michael V. McConnell, Dwight Nishimura, Phillip Harnish and Phillip C. Yang
    Citation: Cardiovascular Diabetology 2016 15:24
    Content type: Original investigation Published on:

  30. Gestational diabetes mellitus (GDM) is a significant risk factor for cardiovascular disease (CVD) in later life. Pentraxin 3 (PTX3) is an essential component of innate immunity and independently associated wit...

    Authors: Tove Lekva, Annika Elisabeth Michelsen, Jens Bollerslev, Errol R. Norwitz, Pål Aukrust, Tore Henriksen and Thor Ueland
    Citation: Cardiovascular Diabetology 2016 15:23
    Content type: Original investigation Published on:

  31. Patients with type 2 diabetes mellitus (T2DM) are at high risk for cardiovascular events. The aim of the study was to assess whether global longitudinal strain (GLS) provides prognostic value in these patients.

    Authors: Ju-Hua Liu, Yan Chen, Michele Yuen, Zhe Zhen, Carmen Wing-Sze Chan, Karen Siu-Ling Lam, Hung-Fat Tse and Kai-Hang Yiu
    Citation: Cardiovascular Diabetology 2016 15:22
    Content type: Original investigation Published on:

  32. Glucagon-like peptide-1 (GLP-1) is an incretin hormone, which gets secreted in response to nutritional stimuli from the gut mediating glucose-dependent insulin secretion. Interestingly, GLP-1 was recently foun...

    Authors: Corinna Lebherz, Florian Kahles, Katja Piotrowski, Michael Vogeser, Ann Christina Foldenauer, Kirsten Nassau, Erich Kilger, Nikolaus Marx, Klaus G. Parhofer and Michael Lehrke
    Citation: Cardiovascular Diabetology 2016 15:21
    Content type: Original Investigation Published on:

  33. The genetic contribution to complex diseases or traits, including cardio-metabolic traits, has been elucidated recently by large-scale genome-wide association studies. These genome-wide association studies hav...

    Authors: Yun Kyoung Kim, Mi Yeong Hwang, Young Jin Kim, Sanghoon Moon, Sohee Han and Bong-Jo Kim
    Citation: Cardiovascular Diabetology 2016 15:20
    Content type: Original investigation Published on:

  34. Abnormalities in lipid and glucose metabolism are constantly observed in type 2 diabetes. However, these abnormalities can be ameliorated by polydatin. Considering the important role of proprotein convertase s...

    Authors: Yu Wang, Jiantao Ye, Jie Li, Cheng Chen, Junying Huang, Peiqing Liu and Heqing Huang
    Citation: Cardiovascular Diabetology 2016 15:19
    Content type: Original investigation Published on:

  35. We tested the hypothesis that glucose-induced hyperosmolarity, occurring in diabetic hyperglycemia, promotes retinal angiogenesis, and that interference with osmolarity signaling ameliorates excessive angiogen...

    Authors: Rosalinda Madonna, Gaia Giovannelli, Pamela Confalone, Francesca Vera Renna, Yong-Jian Geng and Raffaele De Caterina
    Citation: Cardiovascular Diabetology 2016 15:18
    Content type: Original investigation Published on:

  36. Despite its beneficial role on insulin resistance and atherosclerosis, adiponectin has been repeatedly reported as an independent positive predictor of cardiovascular mortality.

    Authors: Lorena Ortega Moreno, Massimiliano Copetti, Andrea Fontana, Concetta De Bonis, Lucia Salvemini, Vincenzo Trischitta and Claudia Menzaghi
    Citation: Cardiovascular Diabetology 2016 15:17
    Content type: Original Investigation Published on:

  37. Both uremia and metabolic syndrome (MetS) affect heart rate variability (HRV) which is a risk factor of poor prognoses. The aim of this study was to evaluate the impact of MetS on HRV among chronic hemodialysi...

    Authors: Yu-Ming Chang, Chih-Chung Shiao, Ya-Ting Huang, I-Ling Chen, Chuan-Lan Yang, Show-Chin Leu, Hung-Li Su, Jsun-Liang Kao, Shih-Ching Tsai, Rong-Na Jhen and Ching-Cherng Uen
    Citation: Cardiovascular Diabetology 2016 15:16
    Content type: Original investigation Published on:

    The Erratum to this article has been published in Cardiovascular Diabetology 2017 16:90

  38. The effect of gestational diabetes mellitus (GDM) on cardiovascular diseases (CVD) is not assessed within the first 10 years postpartum, regardless of subsequent diabetes. The aim of this study was to determin...

    Authors: Karine Goueslard, Jonathan Cottenet, Anne-Sophie Mariet, Maurice Giroud, Yves Cottin, Jean-Michel Petit and Catherine Quantin
    Citation: Cardiovascular Diabetology 2016 15:15
    Content type: Original investigation Published on:

  39. Older patients with longstanding type 1 diabetes have high cardiovascular disease (CVD) risk such that statin therapy is recommended independent of prior CVD events. We aimed to determine self-reported CVD pr...

    Authors: Johnny W. Bai, Geneviève Boulet, Elise M. Halpern, Leif E. Lovblom, Devrim Eldelekli, Hillary A. Keenan, Michael Brent, Narinder Paul, Vera Bril, David Z. I. Cherney, Alanna Weisman and Bruce A. Perkins
    Citation: Cardiovascular Diabetology 2016 15:14
    Content type: Original investigation Published on:

  40. Carotid intima-media thickness (cIMT) holds prognostic information for future cardiovascular disease and is associated with the extent of coronary atherosclerosis. We investigated the effect of exercise on cIM...

    Authors: Rune Byrkjeland, Knut-Haakon Stensæth, Sigmund Anderssen, Ida U. Njerve, Harald Arnesen, Ingebjørg Seljeflot and Svein Solheim
    Citation: Cardiovascular Diabetology 2016 15:13
    Content type: Original investigation Published on:

  41. Lipoprotein-related mechanisms have been associated with damage to the cardiovascular system in diabetic patients. Apolipoprotein E gene which affects the clearance of lipoproteins and consequently the lipid p...

    Authors: Dalia El-Lebedy, Hala M. Raslan and Asmaa M. Mohammed
    Citation: Cardiovascular Diabetology 2016 15:12
    Content type: Original investigation Published on:

    The Erratum to this article has been published in Cardiovascular Diabetology 2016 15:35

  42. Recent data support the renewed interest in hypertriglyceridemia as a possible important therapeutic target for cardiovascular risk reduction. This study was designed to address the question of all-cause morta...

    Authors: Yaron Arbel, Robert Klempfner, Aharon Erez, Ilan Goldenberg, Sagit Benzekry, Nir Shlomo, Enrique Z. Fisman and Alexander Tenenbaum
    Citation: Cardiovascular Diabetology 2016 15:11
    Content type: Original investigation Published on:

  43. We aimed to investigate whether visceral adiposity could modify the impact of blood pressure on arterial stiffness and albuminuria in patients with type 2 diabetes.

    Authors: Ryotaro Bouchi, Norihiko Ohara, Masahiro Asakawa, Yujiro Nakano, Takato Takeuchi, Masanori Murakami, Yuriko Sasahara, Mitsuyuki Numasawa, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto and Yoshihiro Ogawa
    Citation: Cardiovascular Diabetology 2016 15:10
    Content type: Original investigation Published on:

  44. The aims of this study were to investigate whether circulating irisin is associated with favorable metabolic parameters and how the association differs according to body composition in humans.

    Authors: You-Cheol Hwang, Won Seon Jeon, Cheol-Young Park and Byung-Soo Youn
    Citation: Cardiovascular Diabetology 2016 15:9
    Content type: Original Investigation Published on:

  45. Hypertension is a multi-factorial disease of increasing prevalence and a major risk factor for cardiovascular mortality even in the presence of adequate treatment. Progression of cardiovascular disease (CVD) o...

    Authors: Laura Gonzalez-Calero, Marta Martin-Lorenzo, Fernando de la Cuesta, Aroa S. Maroto, Montserrat Baldan-Martin, Gema Ruiz-Hurtado, Helena Pulido-Olmo, Julian Segura, Maria G. Barderas, Luis M. Ruilope, Fernando Vivanco and Gloria Alvarez-Llamas
    Citation: Cardiovascular Diabetology 2016 15:8
    Content type: Original investigation Published on:

  46. The prevention of cardiovascular disease, including diastolic cardiac dysfunction with its high prevalence and ominous prognosis, is a therapeutic challenge for patients with type 2 diabetes. Both short and lo...

    Authors: Helene von Bibra, Thorsten Siegmund, Iris Kingreen, Markus Riemer, Tibor Schuster and Petra-Maria Schumm-Draeger
    Citation: Cardiovascular Diabetology 2016 15:7
    Content type: Original investigation Published on:

  47. Platelet hyper-reactivity is a crucial cause of accelerated atherosclerosis increasing risk of thrombotic vascular events in diabetic patients. The mechanisms leading to abnormal platelet activity during diab...

    Authors: Wenqing Wang, Wayne Bond Lau, Yajing Wang, Xinliang Ma and Rong Li
    Citation: Cardiovascular Diabetology 2016 15:6
    Content type: Original investigation Published on:

  48. We evaluated the risks of renal and cardiovascular complications, and mortality associated with lower extremity amputation (LEA) in patients with type 1 diabetes.

    Authors: Kamel Mohammedi, Louis Potier, Narimène Belhatem, Nadia Matallah, Samy Hadjadj, Ronan Roussel, Michel Marre and Gilberto Velho
    Citation: Cardiovascular Diabetology 2016 15:5
    Content type: Original investigation Published on:

  49. Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). Circadian rhythms are generated by...

    Authors: Dolores Corella, Eva. M. Asensio, Oscar Coltell, José V. Sorlí, Ramón Estruch, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Olga Castañer, Fernando Arós, José Lapetra, Lluís Serra-Majem, Enrique Gómez-Gracia, Carolina Ortega-Azorín, Miquel Fiol, Javier Díez Espino, Andrés Díaz-López…
    Citation: Cardiovascular Diabetology 2016 15:4
    Content type: Original investigation Published on:

  50. Betatrophin is a newly identified liver-derived hormone that is associated with glucose homeostasis and lipid metabolism. Although dysregulated lipid metabolism results in diabetic nephropathy (DN) development...

    Authors: Chang-Chiang Chen, Hendra Susanto, Wen-Han Chuang, Ta-Yu Liu and Chih-Hong Wang
    Citation: Cardiovascular Diabetology 2016 15:3
    Content type: Original investigation Published on:

    The Erratum to this article has been published in Cardiovascular Diabetology 2017 16:58

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