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  1. Diabetes is associated with a high risk of death due to coronary artery disease (CAD). People with diabetes suffering from CAD are frequently treated with revascularization procedures. We aim to compare trends...

    Authors: Ana Lopez-de-Andres, Rodrigo Jimenez-García, Valentin Hernandez-Barrera, Napoleon Perez-Farinos, Jose M de Miguel-Yanes, Manuel Mendez-Bailon, Isabel Jimenez-Trujillo, Angel Gil de Miguel, Carmen Gallardo Pino and Pilar Carrasco-Garrido
    Citation: Cardiovascular Diabetology 2014 13:3
    Content type: Original investigation Published on:

  2. An increased leukocyte count is an independent risk factor for cardiovascular events, but the association between leukocyte subtype counts and carotid atherosclerosis in patients with diabetes has not been det...

    Authors: Takeshi Matsumura, Kayo Taketa, Hiroyuki Motoshima, Takafumi Senokuchi, Norio Ishii, Hiroyuki Kinoshita, Kazuki Fukuda, Sarie Yamada, Daisuke Kukidome, Tatsuya Kondo, Aya Hisada, Takahiko Katoh, Seiya Shimoda, Takeshi Nishikawa and Eiichi Araki
    Citation: Cardiovascular Diabetology 2013 12:177
    Content type: Original investigation Published on:

  3. The lipocalin-2 (LCN2) cytokine, primarily known as a protein of the granules of human neutrophils, has been recently reported to be implicated in metabolic and inflammatory disorders. This study was designed ...

    Authors: Jie Ni, Xiaojing Ma, Mi Zhou, Xiaoping Pan, Junling Tang, Yaping Hao, Zhigang Lu, Meifang Gao, Yuqian Bao and Weiping Jia
    Citation: Cardiovascular Diabetology 2013 12:176
    Content type: Original investigation Published on:

  4. The anti-diabetic drug metformin has been demonstrated to exert a protective effect against vascular complications in diabetes independent of its glucose lowering action. Since the endothelial glycocalyx has b...

    Authors: Bart JM Eskens, Coert J Zuurbier, Judith van Haare, Hans Vink and Jurgen WGE van Teeffelen
    Citation: Cardiovascular Diabetology 2013 12:175
    Content type: Original investigation Published on:

  5. Previous studies suggested an impaired endothelial function in patients with diabetes. However, the validity of this finding may be limited by the lack of adequate adjustment for further cardiovascular confoun...

    Authors: Klaus Empen, Roberto Lorbeer, Henry Völzke, Thorsten Reffelmann, Sabine Schipf, Matthias Nauck, Wolfgang Kerner, Henri Wallaschofski, Stephan B Felix and Marcus Dörr
    Citation: Cardiovascular Diabetology 2013 12:174
    Content type: Original investigation Published on:

  6. Atherosclerosis is a major health burden. Metabolic disorders had been associated with large consumption of soft drinks. The rising incidence of atherosclerosis and metabolic alterations warrants the study of ...

    Authors: Matilde E Otero-Losada, Santiago Mc Loughlin, Gastón Rodríguez-Granillo, Angélica Müller, Graciela Ottaviano, Marisa Moriondo, Juan C Cutrin and José Milei
    Citation: Cardiovascular Diabetology 2013 12:57
    Content type: Original investigation Published on:

  7. We have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult sub...

    Authors: Camila C Leança, Valéria S Nunes, Natália B Panzoldo, Vanessa S Zago, Eliane S Parra, Patrícia M Cazita, Matti Jauhiainen, Marisa Passarelli, Edna R Nakandakare, Eliana C de Faria and Eder CR Quintão
    Citation: Cardiovascular Diabetology 2013 12:173
    Content type: Original investigation Published on:

  8. Cardiac steatosis and apoptosis are key processes in diabetic cardiomyopathy, but the underlying mechanisms have not been elucidated, leading to a lack of effective therapy. The mineralocorticoid receptor bloc...

    Authors: Elisa Ramírez, Mercedes Klett-Mingo, Sara Ares-Carrasco, Belén Picatoste, Alessia Ferrarini, Francisco J Rupérez, Alicia Caro-Vadillo, Coral Barbas, Jesús Egido, José Tuñón and Óscar Lorenzo
    Citation: Cardiovascular Diabetology 2013 12:172
    Content type: Original investigation Published on:

  9. The presence of diabetes and plasma glucose concentration on admission are associated with adverse outcomes after an acute myocardial infarction (AMI), as high glucose can induce vascular endothelial cell apop...

    Authors: Jing Chang, Gong Zhang, Li Zhang, Yuan-Ping Hou, Xiu-Lan Liu and Lin Zhang
    Citation: Cardiovascular Diabetology 2013 12:171
    Content type: Original investigation Published on:

  10. Ethnic-specific differences in insulin resistance (IR) are well described but the underlying mechanisms are unknown. Adiponectin is an insulin sensitizing adipocytokine that circulates as multiple isoforms, wi...

    Authors: Dian C Sulistyoningrum, Danijela Gasevic, Scott A Lear, Joe Ho, Andrew Mente and Angela M Devlin
    Citation: Cardiovascular Diabetology 2013 12:170
    Content type: Original investigation Published on:

  11. Diabetes-induced organ damage is significantly associated with the activation of the renin-angiotensin system (RAS). Recently, several studies have demonstrated a change in the RAS from an extracellular to an ...

    Authors: Qian Chen Yong, Candice M Thomas, Rachid Seqqat, Niketa Chandel, Kenneth M Baker and Rajesh Kumar
    Citation: Cardiovascular Diabetology 2013 12:169
    Content type: Original investigation Published on:

  12. Elevated plasma preprovasopressin (copeptin) levels are associated with cardiovascular complications as well as with an increased risk for type 2 diabetes (T2D). Here, we studied, whether plasma copeptin is re...

    Authors: Cornelia Then, Bernd Kowall, Andreas Lechner, Christa Meisinger, Margit Heier, Wolfgang Koenig, Annette Peters, Joachim Thiery, Wolfgang Rathmann and Jochen Seissler
    Citation: Cardiovascular Diabetology 2013 12:168
    Content type: Original investigation Published on:

  13. Long pentraxin 3 (PTX3) is a component of the pentraxin superfamily and a potential marker of vascular damage and inflammation, associated with negative outcome in patients with acute coronary syndromes (ACS)....

    Authors: Rocco Barazzoni, Aneta Aleksova, Cosimo Carriere, Maria Rosa Cattin, Michela Zanetti, Pierandrea Vinci, Davide Stolfo, Gianfranco Guarnieri and Gianfranco Sinagra
    Citation: Cardiovascular Diabetology 2013 12:167
    Content type: Original investigation Published on:

  14. Bilirubin has been implicated in cardiovascular protection by virtue of its anti-inflammatory and anti-oxidative properties. The metabolic syndrome is featured by enhanced low-grade systemic inflammation and o...

    Authors: Petronella E Deetman, Stephan JL Bakker and Robin PF Dullaart
    Citation: Cardiovascular Diabetology 2013 12:166
    Content type: Original investigation Published on:

  15. We investigated whether serum glycated albumin (GA) levels are related to coronary collateralization in type 2 diabetic patients with chronic total occlusion.

    Authors: Ying Shen, Lin Lu, Feng Hua Ding, Zhen Sun, Rui Yan Zhang, Qi Zhang, Zheng Kun Yang, Jian Hu, Qiu Jing Chen and Wei Feng Shen
    Citation: Cardiovascular Diabetology 2013 12:165
    Content type: Original investigation Published on:

  16. There is little information about predictive ability of haemoglobin A1c (HbA1c) for cardiovascular disease (CVD) in Asians. To investigate the discriminatory ability of HbA1c to identify subjects who are at gr...

    Authors: Fumie Ikeda, Yasufumi Doi, Toshiharu Ninomiya, Yoichiro Hirakawa, Naoko Mukai, Jun Hata, Kentaro Shikata, Daigo Yoshida, Takayuki Matsumoto, Takanari Kitazono and Yutaka Kiyohara
    Citation: Cardiovascular Diabetology 2013 12:164
    Content type: Original investigation Published on:

  17. There are numerous reports describing the efficacy of fenofibrate in combination with ezetimibe for treating dyslipidemia. In contrast, a study combining bezafibrate and ezetimibe has not yet been conducted. I...

    Authors: Tamio Teramoto, Kazunori Abe and Takehiko Taneyama
    Citation: Cardiovascular Diabetology 2013 12:163
    Content type: Original investigation Published on:

  18. We tested whether fatty liver, brachial-ankle pulse wave velocity (baPWV) and conventional cardiovascular risk factors were associated with a coronary artery calcium (CAC) score > 0 (as a marker of the presenc...

    Authors: Ki-Chul Sung, Young-Hyo Lim, Sungha Park, Seok-Min Kang, Jeong Bae Park, Byung-Jin Kim and Jin-Ho Shin
    Citation: Cardiovascular Diabetology 2013 12:162
    Content type: Original investigation Published on:

  19. Coronary artery calcification (CAC) is closely related to coronary atherosclerosis. However, less is known about the clinical significance of extensive CAC (ECAC) in regard to types of first coronary events (a...

    Authors: Joseph Shemesh, Alexander Tenenbaum, Enrique Z Fisman, Nira Koren-Morag and Ehud Grossman
    Citation: Cardiovascular Diabetology 2013 12:161
    Content type: Original investigation Published on:

  20. Dipeptidyl peptidase-4 (DPP-4) inhibitors modulate incretin hormones and exert anti-diabetic effects in type 2 diabetes mellitus. Treatment with angiotensin II type 1 receptor blockers (ARB) is a proven succes...

    Authors: Katsutoshi Miyagawa, Tatsuya Kondo, Rieko Goto, Rina Matsuyama, Kaoru Ono, Sayaka Kitano, Shuji Kawasaki, Motoyuki Igata, Junji Kawashima, Takeshi Matsumura, Hiroyuki Motoshima and Eiichi Araki
    Citation: Cardiovascular Diabetology 2013 12:160
    Content type: Original investigation Published on:

  21. Angiotensin II type 1 receptor blockers (ARB) are a frequently used class of antihypertensive drug. The ARB losartan is known to decrease the serum uric acid (SUA) level. However, there are very few clinical d...

    Authors: Yayoi Nishida, Yasuo Takahashi, Norio Susa, Nobukazu Kanou, Tomohiro Nakayama and Satoshi Asai
    Citation: Cardiovascular Diabetology 2013 12:159
    Content type: Original investigation Published on:

  22. Endoplasmic reticulum (ER) stress is considered one of the mechanisms contributing to reactive oxygen species (ROS)- mediated cell apoptosis. In diabetic cardiomyopathy (DCM), cell apoptosis is generally accep...

    Authors: Zhong-Wei Liu, Hai-Tao Zhu, Kun-Lun Chen, Xin Dong, Jin Wei, Chuan Qiu and Jia-Hong Xue
    Citation: Cardiovascular Diabetology 2013 12:158
    Content type: Original investigation Published on:

  23. Cystatin C (Cys C) is a marker of renal dysfunction. Prior studies have shown that blood Cys C is related to the prognosis of coronary heart disease. The aim of the present study was to evaluate the long-term ...

    Authors: Zhenhong Fu, Hao Xue, Jun Guo, Lian Chen, Wei Dong, Luyue Gai, Hongbin Liu, Zhijun Sun and Yundai Chen
    Citation: Cardiovascular Diabetology 2013 12:157
    Content type: Original investigation Published on:

  25. The presence of cardiovascular disease (CVD) in Type 1 diabetes largely impairs life expectancy. Hyperglycemia leading to an increase in oxidative stress is considered to be the key pathophysiological factor o...

    Authors: Oliver Schnell, Francesco Cappuccio, Stefano Genovese, Eberhard Standl, Paul Valensi and Antonio Ceriello
    Citation: Cardiovascular Diabetology 2013 12:156
    Content type: Review Published on:

  26. Intima-media thickness (IMT) is a validated marker of preclinical atherosclerosis and a predictor of cardiovascular events.

    Authors: Salvatore Novo, Angelica Peritore, Rosaria Linda Trovato, Francesco Paolo Guarneri, Daniela Di Lisi, Ida Muratori and Giuseppina Novo
    Citation: Cardiovascular Diabetology 2013 12:155
    Content type: Original investigation Published on:

  27. The dipeptidyl peptidase-4 (DPP-4) inhibitors Sitagliptin and Vildagliptin lower blood glucose by augmenting endogenous levels of glucagon-like peptide-1 (GLP-1), an incretin which also confers cardioprotectio...

    Authors: Derek J Hausenloy, Hannah J Whittington, Abigail M Wynne, Shah S Begum, Louise Theodorou, Niels Riksen, Mihaela M Mocanu and Derek M Yellon
    Citation: Cardiovascular Diabetology 2013 12:154
    Content type: Original investigation Published on:

  28. Detection of early vascular changes prior to clinical manifestations of atherosclerosis, such as increased arterial carotid intima-media thickness (CIMT) and impaired endothelial function is of paramount impor...

    Authors: Sema Ciftci Dogansen, Aysen Helvaci, Mine Adas and Suzan Deniz Onal
    Citation: Cardiovascular Diabetology 2013 12:153
    Content type: Original investigation Published on:

  29. The combination of systemic arterial hypertension and diabetes mellitus (DM) induces greater cardiac remodeling than either condition alone. However, this association has been poorly addressed in senescent rat...

    Authors: Camila Moreno Rosa, Natasha Priscilla Xavier, Dijon Henrique Campos, Ana Angélica Henrique Fernandes, Marcelo Diarcadia Mariano Cezar, Paula Felippe Martinez, Antonio Carlos Cicogna, Camila Gimenes, Rodrigo Gimenes, Marina Politi Okoshi and Katashi Okoshi
    Citation: Cardiovascular Diabetology 2013 12:152
    Content type: Original investigation Published on:

  30. Activation of the renin-angiotensin system (RAS) plays a critical role in the pathophysiology of myocardial infarction (MI) and the development of heart failure. Both angiotensin-converting enzyme 2 (ACE2) and...

    Authors: Wei Liu, Xinmin Zhou, Fenglei Yu, Jianguo Hu and Wen Hu
    Citation: Cardiovascular Diabetology 2013 12:151
    Content type: Original investigation Published on:

  31. Activin A released from epicardial adipose tissue has been linked to contractile dysfunction and insulin resistance in cardiomyocytes. This study investigated the role of activin A in clinical diabetic cardiom...

    Authors: Weena JY Chen, Sabrina Greulich, Rutger W van der Meer, Luuk J Rijzewijk, Hildo J Lamb, Albert de Roos, Johannes WA Smit, Johannes A Romijn, Johannes B Ruige, Adriaan A Lammertsma, Mark Lubberink, Michaela Diamant and D Margriet Ouwens
    Citation: Cardiovascular Diabetology 2013 12:150
    Content type: Original investigation Published on:

  32. Advanced glycation endproducts (AGEs) may play a role in the development of coronary artery calcification (CAC) in type 1 diabetes (T1DM). We studied plasma AGEs in association with T1DM and CAC, and whether o...

    Authors: Marcelle GA van Eupen, Miranda T Schram, Helen M Colhoun, Jean LJM Scheijen, Coen DA Stehouwer and Casper G Schalkwijk
    Citation: Cardiovascular Diabetology 2013 12:149
    Content type: Original investigation Published on:

  33. Glucagon-like peptide-1 (GLP-1) and its mimetics reduce infarct size in the setting of acute myocardial ischemia/reperfusion (I/R) injury. However, the short serum half-life of GLP-1 and its mimetics may limit...

    Authors: Weike Bao, Lucy J Holt, Rob D Prince, Gavin X Jones, Karpagam Aravindhan, Mathew Szapacs, April M Barbour, Larry J Jolivette, John J Lepore, Robert N Willette, Elena DeAngelis and Beat M Jucker
    Citation: Cardiovascular Diabetology 2013 12:148
    Content type: Original investigation Published on:

  34. The high glucose-induced proliferation of vascular smooth muscle cells (VSMCs) plays an important role in the development of diabetic vascular diseases. In a previous study, we confirmed that Interferon regula...

    Authors: Xi Zhang, Long Liu, Chao Chen, Ya-Li Chi, Xiang-Qun Yang, Yan Xu, Xiao-Tong Li, Shi-Lei Guo, Shao-Hu Xiong, Man-Ru Shen, Yu Sun, Chuan-Sen Zhang and Kai-Meng Hu
    Citation: Cardiovascular Diabetology 2013 12:147
    Content type: Original investigation Published on:

  35. The prevalence of diabetes in China is increasing rapidly. However, scarce data are available on serum electrolyte levels in Chinese adults with diabetes, especially in those with cardiovascular complications....

    Authors: Shenqi Wang, Xuhong Hou, Yu Liu, Huijuan Lu, Li Wei, Yuqian Bao and Weiping Jia
    Citation: Cardiovascular Diabetology 2013 12:146
    Content type: Original investigation Published on:

  36. Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthesis inhibitor, and insulin resistance (IR) have been implicated in atherogenesis. Our aim was to estimate relations between ADMA, the magnit...

    Authors: Olga Kruszelnicka, Andrzej Surdacki and Alain Golay
    Citation: Cardiovascular Diabetology 2013 12:145
    Content type: Original investigation Published on:

  37. Patients with type 2 diabetes mellitus (T2DM) present subclinical left ventricular systolic and/or diastolic dysfunction (LVD). Dipeptidyl peptidase-4 (DPP4) inactivates peptides that possess cardioprotective ...

    Authors: Susana Ravassa, Joaquín Barba, Isabel Coma-Canella, Ana Huerta, Begoña López, Arantxa González and Javier Díez
    Citation: Cardiovascular Diabetology 2013 12:143
    Content type: Original investigation Published on:

  38. Endothelial dysfunction precedes pathogenesis of vascular complications in diabetes. In recent years, the mechanisms of endothelial dysfunction were investigated to outline strategies for its treatment. Howeve...

    Authors: Hemang Patel, Juan Chen, Kumuda C Das and Mahendra Kavdia
    Citation: Cardiovascular Diabetology 2013 12:142
    Content type: Original investigation Published on:

  39. Accumulation of advanced glycation end products (AGEs) in the vasculature triggers a series of morphological and functional changes contributing to endothelial hyperpermeability. The reorganisation and redistr...

    Authors: Zhenyu Li, Qiaoqing Zhong, Tianlun Yang, Xiumei Xie and Meifang Chen
    Citation: Cardiovascular Diabetology 2013 12:141
    Content type: Original investigation Published on:

  40. It is a matter of debate whether metabolic syndrome (MS) improves cardiovascular risk prediction beyond the risk associated with its individual components. The present study examined the association of MS scor...

    Authors: Jong-Youn Kim, Eui-Young Choi, Hee-Sun Mun, Pil-Ki Min, Young-Won Yoon, Byoung Kwon Lee, Bum-Kee Hong, Se-Joong Rim and Hyuck Moon Kwon
    Citation: Cardiovascular Diabetology 2013 12:140
    Content type: Original investigation Published on:

  41. Development of a cardiomyopathy in diabetes mellitus is independent of traditional risk factors, with no clinical trials targeting specific therapeutic interventions. Myocardial fibrosis is one of the key mech...

    Authors: Melissa Leung, Vincent W Wong, Stephane Heritier, Anastasia S Mihailidou and Dominic Y Leung
    Citation: Cardiovascular Diabetology 2013 12:139
    Content type: Study protocol Published on:

  42. Dyslipidemia, a major risk factor for cardiovascular disease is a common finding in patients with type 2 diabetes and among women with gestational diabetes. Elevated levels of lipoprotein(a) [Lp(a)] are linked...

    Authors: Jelena Todoric, Ammon Handisurya, Karoline Leitner, Juergen Harreiter, Gregor Hoermann and Alexandra Kautzky-Willer
    Citation: Cardiovascular Diabetology 2013 12:138
    Content type: Original investigation Published on:

  43. A relationship between plasma adiponectin level and a number of metabolic conditions, including insulin resistance, obesity, and type 2 diabetes, has been reported. This study aimed to assess whether urinary a...

    Authors: Won Seon Jeon, Ji Woo Park, Namseok Lee, Se Eun Park, Eun Jung Rhee, Won Young Lee, Ki Won Oh, Sung Woo Park, Cheol-Young Park and Byung-Soo Youn
    Citation: Cardiovascular Diabetology 2013 12:137
    Content type: Original investigation Published on:

  44. To study the pathogenesis of diabetic cardiomyopathy, reliable animal models of type 2 diabetes are required. Physiologically relevant rodent models are needed, which not only replicate the human pathology but...

    Authors: Latt S Mansor, Eileen R Gonzalez, Mark A Cole, Damian J Tyler, Jessica H Beeson, Kieran Clarke, Carolyn A Carr and Lisa C Heather
    Citation: Cardiovascular Diabetology 2013 12:136
    Content type: Original investigation Published on:

  46. Increased levels of the sugar metabolite methylglyoxal (MG) in vivo were shown to participate in the pathophysiology of vascular complications in diabetes. Alterations of endothelial nitric oxide synthase (eNOS) ...

    Authors: Yang Su, Syed M Qadri, Lingyun Wu and Lixin Liu
    Citation: Cardiovascular Diabetology 2013 12:134
    Content type: Original investigation Published on:

  47. Large body of evidences accumulated in clinical and epidemiological studies indicate that hearts of diabetic subjects are more sensitive to ischemia reperfusion injury (IRI), which results in a higher rate of ...

    Authors: Haobo Li, Zipeng Liu, Junwen Wang, Gordon T Wong, Chi-Wai Cheung, Liangqing Zhang, Can Chen, Zhengyuan Xia and Michael G Irwin
    Citation: Cardiovascular Diabetology 2013 12:133
    Content type: Original investigation Published on:

  48. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) detoxifies reactive aldehydes in the micro- and macrovasculature. These substrates, including methylglyoxal and 4-hydroxynonenal formed from glucose and lipids, c...

    Authors: Kazunori Morita, Junji Saruwatari, Haruna Miyagawa, Yoshihiro Uchiyashiki, Kentaro Oniki, Misaki Sakata, Ayami Kajiwara, Akira Yoshida, Hideaki Jinnouchi and Kazuko Nakagawa
    Citation: Cardiovascular Diabetology 2013 12:132
    Content type: Original investigation Published on:

  49. The Cardiovascular Risk Evaluation in people with type 2 Diabetes on Insulin Therapy (CREDIT) study is an international, multicenter, observational study designed to assess metabolic parameters and cardiovascu...

    Authors: Ryuzo Kawamori, Koichi Node, Toshiaki Hanafusa, Yoshihito Atsumi, Yusuke Naito and Yoshitomo Oka
    Citation: Cardiovascular Diabetology 2013 12:131
    Content type: Original investigation Published on:
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