Table 1 Comparison of parameters among different NAFLD fibrosis risk stages stratified according to NFS and FIB-4

N (%)

202 (20.30%)

467 (46.94%)

326 (32.76%)

495 (49.75%)

283 (28.44%)

217 (21.81%)

Gender, male (n/%)

127 (62.87%)

299 (64.03%)

185 (56.75%)

318 (64.24%)

170 (60.07%)

123 (56.68%)

Age (Year)

50.0 (42.3, 58.0)

61.0 (54.0, 66.0)^b

70.0 (66.0, 77.0)^bd

57.5 (48.0, 65.0)

64.0 (59.0, 70.0)^b

71.0 (65.0, 77.0)^bd

Smoking (n/%)

82 (40.59%)

203 (43.47%)

138 (42.33%)

207 (41.82%)

121 (42.76%)

95 (43.78%)

Arterial hypertension (n/%)

96 (47.52%)

253 (54.18%)

200 (61.35%)

250 (50.51%)

157 (55.48%)

142 (65.44%)

waist circumference (cm)

92 (86, 100)

94 (87, 103)

94 (88, 102)

94 (87, 104)

94 (88, 101)

93 (87, 99)

BMI (Kg/m²)

25.59 (24.01, 27.75)

26.67 (24.69, 28.85)

26.42 (24.54, 28.73)

26.84 (24.69, 29.30)

26.29 (24.61, 28.40)

26.18 (23.80, 28.09)^a

Duration of diabetes (Year)

5 (2, 10)

9 (4, 14)^b

10 (5, 19)^bd

8 (3, 13)

10 (5, 14)^a

10 (5, 18)^b

SBP (mmHg)

130 (118, 140)

130 (120, 141)

135 (122, 145)^bc

130 (120, 141)

135 (121, 145)^b

133 (120, 142)

DBP (mmHg)

80 (72, 88)

80 (70, 88)

77 (70, 84)^bd

80 (71, 89)

80 (70, 86)

75 (70, 82)^bc

FBG (mmol/L)

8.5 (6.6, 10.9)

7.6 (6.1, 9.6)^b

7.7 (5.9, 10.1)^a

7.8 (6.0, 10.1)

7.6 (6.0, 9.5)

8.3 (6.3, 10.8)

HbA₁C (%)

9.0 (7.5, 10.7)

8.3 (7.0, 9.9)

8.4 (7.2, 10.2)^b

8.7 (7.1, 10.2)

8.3 (7.3, 10.1)

8.0 (7.1, 10.1)^b

TC (mmol/L)

4.64 (3.80, 5.48)

4.32 (3.42, 4.97)^b

3.87 (3.21, 4.77)^bd

4.42 (3.54, 5.11)

3.97 (3.32, 4.97)^a

4.00 (3.19, 4.76)^b

TG (mmol/L)

2.05 (1.45, 3.00)

1.73 (1.28, 2.68)^a

1.55 (1.10, 2.27)^bc

1.81 (1.33, 2.87)

1.67 (1.14, 2.45)

1.58 (1.13, 2.25)^b

HDL-C (mmol/L)

0.96 (0.81, 1.13)

0.94 (0.80, 1.13)

0.99 (0.83, 1.19)

0.93 (0.80, 1.13)

0.99 (0.82, 1.16)

0.99 (0.84, 1.17)^a

LDL-C (mmol/L)

2.91 (2.19, 3.77)

2.70 (1.97, 3.44)

2.49 (1.77, 3.17)^bc

2.79 (2.03, 3.50)

2.55 (1.84, 3.26)^a

2.43 (1.80, 3.25)^b

ALT (μ/L)

27.0 (18.2, 41.6)

20.3 (14.6, 34.0)^a

19.0 (13.0, 30.5)^b

20.0 (14.1, 29.9)

19.5 (13.9, 34.0)

27.0 (16.7, 39.9)^bc

AST (μ/L)

18.0 (14.0, 24.8)

17.2 (13.8, 26.0)

20.8 (15.0, 38.6)^bd

16.0 (13.0, 21.0)

19.0 (14.6, 28.5)^b

31.1 (20.3, 102.1)^bd

Total protein (g/L)

69.8 ± 6.4

68.2 ± 6.2^b

65.8 ± 6.2^bd

68.5 (65.0, 73.9)

70.0 (65.1, 72.6)

65.9 (61.4, 70.5)^bd

Albumin (g/L)

45.4 (42.9, 48.2)

43.0 (41.0, 46.6)^b

40.3 (38.2, 43.0)^bd

43.6 (41.0, 46.8)

42.4 (40.0, 46.0)^a

40.0 (38.3, 43.0)^bd

Prealbumin (g/L)

0.28 (0.23, 0.32)

0.25 (0.22, 0.28)^b

0.23 (0.19, 0.25)^bd

0.26 (0.22, 0.29)

0.24 (0.22, 0.27)^a

0.21 (0.17, 0.25)^bd

Globulin (g/L)

23.8 ± 5.06

24.7 ± 4.3

25.1 ± 5.1^a

24.8 (21.5, 28.4)

25.0 (22.2, 27.4)

25.9 (22.9, 28.3)

γ-GT (μ/L)

29.5 (22.0, 43.8)

28.0 (19.0, 43.8)

25.0 (19.0, 38.0)^b

26.0 (20.0, 41.0)

28.5 (19.0, 41.0)

29.0 (21.0, 51.2)^b

WBC (× 10⁹/L)

6.89 (5.61, 8.29)

6.64 (5.66, 7.57)

6.38 (5.14, 8.39)

6.72 (5.71, 7.88)

6.45 (5.50, 7.44)^a

6.35 (4.92, 9.09)

Neutrophil (%)

57.4 ± 8.9

60.2 ± 8.9^b

63.4 ± 11.5^bd

60.0 (53.6, 65.9)

59.8 (54.2, 64.8)

65.8 (56.5, 75.1)^bd

Neutrophil (× 10⁹/L)

4.13 (3.05, 5.08)

3.86 (3.16, 4.83)

3.97 (2.91, 5.76)

4.02 (3.27, 5.00)

3.61 (3.00, 4.57)^a

4.02 (2.75, 6.87)^d

Lymphocyte (%)

31.95 (26.95, 36.60)

28.35 (24.13, 35.38)^b

27.15 (19.33, 32.60)^bd

29.50 (24.83, 35.48)

28.80 (24.58, 34.60)

23.80 (15.70, 32.25)^bd

Lymphocyte (× 10⁹/L)

2.11 (1.74, 2.66)

1.92 (1.48, 2.35)^b

1.63 (1.31, 2.04)^bd

1.99 (1.65, 2.41)

1.82 (1.42, 2.35)^b

1.49 (1.15, 1.92)^bd

Neutrophil/ lymphocyte

1.81 (1.45, 2.39)

2.13 (1.51, 2.72)^a

2.33 (1.73, 3.69)^bd

2.04 (1.52, 2.69)

2.01 (1.61, 2.57)

2.79 (1.77, 4.92)^bd

Eosinophilic granulocyte (%)

2.0 (1.2, 2.8)

2.0 (1.3, 3.2)

2.2 (1.4, 3.3)

1.6 (1.2, 2.9)

2.3 (1.6, 3.5)^b

2.3 (1.6, 3.3)

Basophilic granulocyte (%)

0.4 (0.3, 0.5)

0.4 (0.2, 0.6)

0.4 (0.2, 0.5)

0.4 (0.2, 0.5)

0.4 (0.2, 0.6)

0.3 (0.2, 0.5)

Mononuclear leucocyte (%)

6.6 (5.2, 8.1)

6.8 (5.8, 7.9)

7.4 (5.9, 8.7)^a

6.6 (5.3, 7.7)

6.9 (5.9, 8.2)

7.6 (6.4, 8.4)^a

PLT (× 10⁹/L)

266 (245, 314)

209 (177, 241)^b

168 (138, 197)^bd

237 (205, 272)

173 (152, 204)^b

162 (128, 197)^b

RBC (× 10¹²/L)

4.9 (4.5, 5.3)

4.7 (4.3, 5.0)^b

4.4 (3.9, 4.5)^bd

4.7 ± 0.5

4.5 ± 0.6^b

4.1 ± 0.6^bd

HGB (g/L)

144 (135, 159)

141 (128., 151)^b

129 (120, 140)^bd

143 (131, 152)

132 (124, 147)^b

126 (114, 136)^b

TBIL (mmol/L)

9.5 (7.2, 12.2)

10.0 (7.4, 14.0)

9.8 (7.2, 13.0)

9.6 (7.3, 13.7)

10.3 (6.7, 13.9)

9.4 (7.6, 11.6)^bc

DBIL (mmol/L)

3.6 (2.8, 4.3)

3.8 (3.0, 5.0)

3.8 (3.0, 5.2)

3.5 (2.8, 4.6)

3.5 (2.7, 4.9)

3.7 (3.3, 4.3)^bd

Scr (μmol/L)

60.0 (49.0, 75.8)

66.0 (56.0, 80.5)^b

74.5 (58.3, 95.8)^bd

65.0 (55.0, 78.5)

71.0 (58.0, 89.0)

62.0 (54.0, 83.0)^a

UA (μmol/L)

329.5 (267.5, 404.8)

336.5 (275.3, 390.0)

332.0 (276.0, 400.5)

331.0 (277.0, 395.0)

340.5 (275.3, 393.0)

324.0 (257.0, 393.0)

BUN (mmol/L)

5.0 (4.2, 5.8)

5.3 (4.4, 6.5)^a

5.7 (4.7, 7.5)^bd

5.1 (4.4, 6.3)

5.6 (4.5, 6.9)^b

5.4 (4.5, 7.5)^b

C reactive protein (mg/dl)

1.0 (1.0, 3.0)

1.0 (1.0, 3.0)

1.0 (1.0, 2.0)

1.0 (1.0, 3.0)

1.0 (1.0, 3.0)

1.0 (1.0, 2.0)

cTnI (ng/ml)

0.01 (0.01, 0.02)

0.01 (0.01, 0.02)

0.03 (0.01, 7.39)^bd

0.01 (0.01, 0.02)

0.01 (0.01, 0.08)^a

0.76 (0.02, 10.35)^bd

eGFR (ml/min)

106 (92, 116)

94 (78, 103)^b

85 (60, 94)^bd

98 (83, 109)

90 (71, 100)^b

85 (63, 96)^b

AMI (n/%)

28 (13.86%)

131 (28.05%)

166 (50.92%)

100 (20.20%)

87 (30.74%)

138 (63.59%)