Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640–5.
Article
CAS
PubMed
Google Scholar
Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Das SR, et al. Heart disease and stroke statistics-2019 update: a report from the american heart association. Circulation. 2019;139(10):e56-28.
Article
PubMed
Google Scholar
Li X, Fang F, Fu X, Lin H, Gao Q. Is metabolic syndrome associated with the risk of recurrent stroke: a meta-analysis of Cohort Studies. J Stroke Cerebrovasc Dis. 2017;26(12):2700–5.
Article
PubMed
Google Scholar
Roever L, Resende ES, Diniz ALD, Penha-Silva N, O’Connell JL, Gomes PFS, Zanetti HR, Roerver-Borges AS, Veloso FC, Fidale TM, et al. Metabolic syndrome and risk of stroke: protocol for an update systematic review and meta-analysis. Medicine. 2018;97(15):e9862.
Article
PubMed
PubMed Central
Google Scholar
Gami AS, Witt BJ, Howard DE, Erwin PJ, Gami LA, Somers VK, Montori VM. Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol. 2007;49(4):403–14.
Article
CAS
PubMed
Google Scholar
Li X, Lin H, Fu X, Lin W, Li M, Zeng X, Gao Q. Metabolic syndrome and stroke: a meta-analysis of prospective cohort studies. J Clin Neurosci. 2017;40:34–8.
Article
PubMed
Google Scholar
Kernan WN, Inzucchi SE, Viscoli CM, Brass LM, Bravata DM, Shulman GI, McVeety JC, Horwitz RI. Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke. Neurology. 2003;60(9):1447–51.
Article
CAS
PubMed
Google Scholar
Golden SH, Folsom AR, Coresh J, Sharrett AR, Szklo M, Brancati F. Risk factor groupings related to insulin resistance and their synergistic effects on subclinical atherosclerosis: the atherosclerosis risk in communities study. Diabetes. 2002;51(10):3069–76.
Article
CAS
PubMed
Google Scholar
Kernan WN, Viscoli CM, Furie KL, Young LH, Inzucchi SE, Gorman M, Guarino PD, Lovejoy AM, Peduzzi PN, Conwit R, et al. Pioglitazone after ischemic stroke or transient ischemic attack. N Engl J Med. 2016;374(14):1321–31.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cardellini M, Rizza S, Casagrande V, Cardolini I, Ballanti M, Davato F, Porzio O, Canale MP, Legramante JM, Mavilio M, et al. Soluble ST2 is a biomarker for cardiovascular mortality related to abnormal glucose metabolism in high-risk subjects. Acta Diabetol. 2019;56(3):273–80.
Article
CAS
PubMed
Google Scholar
Botvin Moshe C, Haratz S, Ravona-Springer R, Heymann A, Hung-Mo L, Schnaider Beeri M, Tanne D. Long-term trajectories of BMI predict carotid stiffness and plaque volume in type 2 diabetes older adults: a cohort study. Cardiovasc Diabetol. 2020;19(1):138.
Article
PubMed
PubMed Central
Google Scholar
Hansson GK, Libby P. The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol. 2006;6(7):508–19.
Article
CAS
PubMed
Google Scholar
Finn AV, Nakano M, Narula J, Kolodgie FD, Virmani R. Concept of vulnerable/unstable plaque. Arterioscler Thromb Vasc Biol. 2010;30(7):1282–92.
Article
CAS
PubMed
Google Scholar
Spagnoli LG, Mauriello A, Sangiorgi G, Fratoni S, Bonanno E, Schwartz RS, Piepgras DG, Pistolese R, Ippoliti A, Holmes DR Jr. Extracranial thrombotically active carotid plaque as a risk factor for ischemic stroke. JAMA. 2004;292(15):1845–52.
Article
CAS
PubMed
Google Scholar
Mauriello A, Servadei F, Sangiorgi G, Anemona L, Giacobbi E, Liotti D, Spagnoli LG. Asymptomatic carotid plaque rupture with unexpected thrombosis over a non-canonical vulnerable lesion. Atherosclerosis. 2011;218(2):356–62.
Article
CAS
PubMed
Google Scholar
Mauriello A, Sangiorgi GM, Virmani R, Trimarchi S, Holmes DR Jr, Kolodgie FD, Piepgras DG, Piperno G, Liotti D, Narula J, et al. A pathobiologic link between risk factors profile and morphological markers of carotid instability. Atherosclerosis. 2010;208(2):572–80.
Article
CAS
PubMed
Google Scholar
Scimeca M, Anemona L, Granaglia A, Bonfiglio R, Urbano N, Toschi N, Santeusanio G, Schiaroli S, Mauriello S, Tancredi V, et al. Plaque calcification is driven by different mechanisms of mineralization associated with specific cardiovascular risk factors. Nutr Metab Cardiovasc Dis. 2019;29(12):1330–6.
Article
CAS
PubMed
Google Scholar
Cardellini M, Rovella V, Scimeca M, Anemona L, Bischetti S, Casella S, Saggini A, Bonanno E, Ballanti M, Davato F, et al. Chronic kidney disease is linked to carotid nodular calcification, an unstable plaque Not correlated to inflammation. Aging Dis. 2019;10(1):71–81.
Article
PubMed
PubMed Central
Google Scholar
Kernan WN, Ovbiagele B, Black HR, Bravata DM, Chimowitz MI, Ezekowitz MD, Fang MC, Fisher M, Furie KL, Heck DV, et al. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45(7):2160–236.
Article
PubMed
Google Scholar
Eckstein HH. European society for vascular surgery guidelines on the management of atherosclerotic carotid and vertebral artery disease. Eur J Vasc Endovasc Surg. 2018;55(1):1–2.
Article
PubMed
Google Scholar
Halliday A, Harrison M, Hayter E, Kong X, Mansfield A, Marro J, Pan H, Peto R, Potter J, Rahimi K, et al. 10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicentre randomised trial. Lancet. 2010;376(9746):1074–84.
Article
PubMed
PubMed Central
Google Scholar
Tsivgoulis G, Safouris A, Kim DE, Alexandrov AV. Recent advances in primary and secondary prevention of atherosclerotic stroke. J Stroke. 2018;20(2):145–66.
Article
PubMed
PubMed Central
Google Scholar
Guembe MJ, Fernandez-Lazaro CI, Sayon-Orea C, Toledo E, Moreno-Iribas C. Risk for cardiovascular disease associated with metabolic syndrome and its components: a 13-year prospective study in the RIVANA cohort. Cardiovasc Diabetol. 2020;19(1):195.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kumar P, Sharma R, Misra S, Kumar A, Nath M, Nair P, Vibha D, Srivastava AK, Prasad K. CIMT as a risk factor for stroke subtype: a systematic review. Eur J Clin Invest. 2020;50(11):e13348.
Article
PubMed
Google Scholar
Willeit P, Tschiderer L, Allara E, Reuber K, Seekircher L, Gao L, Liao X, Lonn E, Gerstein HC, Yusuf S, et al. Carotid intima-media thickness progression as surrogate marker for cardiovascular risk: Meta-analysis of 119 clinical trials involving 100 667 patients. Circulation. 2020;142(7):621–42.
Article
CAS
PubMed
PubMed Central
Google Scholar
Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20(5):1262–75.
Article
CAS
PubMed
Google Scholar
Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, DePalma SM, Gidding S, Jamerson KA, Jones DW, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2018;71(19):2199–269.
Article
PubMed
Google Scholar
Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, Clement DL, Coca A, de Simone G, Dominiczak A, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: the Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. J Hypertens. 2018;36(10):1953–2041.
Article
CAS
PubMed
Google Scholar
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499–502.
Article
CAS
PubMed
Google Scholar
Eltoft A, Arntzen KA, Wilsgaard T, Mathiesen EB, Johnsen SH. Interleukin-6 is an independent predictor of progressive atherosclerosis in the carotid artery: the Tromso Study. Atherosclerosis. 2018;271:1–8.
Article
CAS
PubMed
Google Scholar
Endrighi R, Hamer M, Steptoe A. Post-menopausal women exhibit greater interleukin-6 responses to mental stress than older men. Ann Behav Med. 2016;50(4):564–71.
Article
PubMed
Google Scholar
Mauriello A, Sangiorgi G, Virmani R, Servadei F, Trimarchi S, Holmes DR Jr, Kolodgie F, Biondi Zoccai G, Leuzzi C, Spagnoli LG. Evidence of a topographical link between unstable carotid plaques and luminal stenosis: can we better stratify asymptomatic patients with significant plaque burden? Int J Cardiol. 2012;155(2):309–11.
Article
PubMed
Google Scholar
Muller JE, Tofler GH, Stone PH. Circadian variation and triggers of onset of acute cardiovascular disease. Circulation. 1989;79(4):733–43.
Article
CAS
PubMed
Google Scholar
Coli S, Magnoni M, Sangiorgi G, Marrocco-Trischitta MM, Melisurgo G, Mauriello A, Spagnoli L, Chiesa R, Cianflone D, Maseri A. Contrast-enhanced ultrasound imaging of intraplaque neovascularization in carotid arteries: correlation with histology and plaque echogenicity. J Am Coll Cardiol. 2008;52(3):223–30.
Article
PubMed
Google Scholar
Mottillo S, Filion KB, Genest J, Joseph L, Pilote L, Poirier P, Rinfret S, Schiffrin EL, Eisenberg MJ. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol. 2010;56(14):1113–32.
Article
PubMed
Google Scholar
Haffner SM, D’Agostino R Jr, Mykkanen L, Tracy R, Howard B, Rewers M, Selby J, Savage PJ, Saad MF. Insulin sensitivity in subjects with type 2 diabetes. Relationship to cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study. Diabetes Care. 1999;22(4):562–8.
Article
CAS
PubMed
Google Scholar
Sheu WH, Jeng CY, Young MS, Le WJ, Chen YT. Coronary artery disease risk predicted by insulin resistance, plasma lipids, and hypertension in people without diabetes. Am J Med Sci. 2000;319(2):84–8.
Article
CAS
PubMed
Google Scholar
Rovella V, Anemona L, Cardellini M, Scimeca M, Saggini A, Santeusanio G, Bonanno E, Montanaro M, Legramante IM, Ippoliti A, et al. The role of obesity in carotid plaque instability: interaction with age, gender, and cardiovascular risk factors. Cardiovasc Diabetol. 2018;17(1):46.
Article
CAS
PubMed
PubMed Central
Google Scholar
Toth PP, Shah PK, Lepor NE. Targeting hypertriglyceridemia to mitigate cardiovascular risk: a review. Am J Prev Cardiol. 2020;3:100086.
Article
PubMed
PubMed Central
Google Scholar
Schwartz GG, Abt M, Bao W, DeMicco D, Kallend D, Miller M, Mundl H, Olsson AG. Fasting triglycerides predict recurrent ischemic events in patients with acute coronary syndrome treated with statins. J Am Coll Cardiol. 2015;65(21):2267–75.
Article
CAS
PubMed
Google Scholar
Reiner Z. Hypertriglyceridaemia and risk of coronary artery disease. Nat Rev Cardiol. 2017;14(7):401–11.
Article
CAS
PubMed
Google Scholar
Jin JL, Zhang HW, Cao YX, Liu HH, Hua Q, Li YF, Zhang Y, Guo YL, Wu NQ, Zhu CG, et al. Long-term prognostic utility of low-density lipoprotein (LDL) triglyceride in real-world patients with coronary artery disease and diabetes or prediabetes. Cardiovasc Diabetol. 2020;19(1):152.
Article
CAS
PubMed
PubMed Central
Google Scholar
Miller M, Cannon CP, Murphy SA, Qin J, Ray KK, Braunwald E. Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial. J Am Coll Cardiol. 2008;51(7):724–30.
Article
CAS
PubMed
Google Scholar
Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB, Doyle RT Jr, Juliano RA, Jiao L, Granowitz C, et al. Cardiovascular risk reduction with Icosapent ethyl for hypertriglyceridemia. N Engl J Med. 2019;380(1):11–22.
Article
CAS
PubMed
Google Scholar
Marz W, Scharnagl H, Winkler K, Tiran A, Nauck M, Boehm BO, Winkelmann BR. Low-density lipoprotein triglycerides associated with low-grade systemic inflammation, adhesion molecules, and angiographic coronary artery disease: The Ludwigshafen Risk and Cardiovascular Health study. Circulation. 2004;110(19):3068–74.
Article
PubMed
CAS
Google Scholar
Nordestgaard BG. Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: New insights from epidemiology, genetics, and biology. Circ Res. 2016;118(4):547–63.
Article
CAS
PubMed
Google Scholar
Doi H, Kugiyama K, Oka H, Sugiyama S, Ogata N, Koide SI, Nakamura SI, Yasue H. Remnant lipoproteins induce proatherothrombogenic molecules in endothelial cells through a redox-sensitive mechanism. Circulation. 2000;102(6):670–6.
Article
CAS
PubMed
Google Scholar
La Fata E, Gentile M, Iannuzzi A, Covetti G, D’Elia L, Iannuzzo G, Panico S, Rubba P. Association between Triglyceride-Rich-Lipoprotein subfractions and carotid atherosclerosis in post-menopausal women. Nutr Metab Cardiovasc Dis. 2017;27(1):e26.
Article
Google Scholar
Ahmad S, Mora S, Franks PW, Orho-Melander M, Ridker PM, Hu FB, Chasman DI. Adiposity and genetic factors in relation to triglycerides and triglyceride-rich lipoproteins in the Women’s Genome Health Study. Clin Chem. 2018;64(1):231–41.
Article
CAS
PubMed
Google Scholar
Sangiorgi G, Roversi S, Biondi Zoccai G, Modena MG, Servadei F, Ippoliti A, Mauriello A. Sex-related differences in carotid plaque features and inflammation. J Vasc Surg. 2013;57(2):338–44.
Article
PubMed
Google Scholar
Burke AP, Farb A, Malcom G, Virmani R. Effect of menopause on plaque morphologic characteristics in coronary atherosclerosis. Am Heart J. 2001;141(2 Suppl):58–62.
Article
Google Scholar
Iemolo F, Martiniuk A, Steinman DA, Spence JD. Sex differences in carotid plaque and stenosis. Stroke. 2004;35(2):477–81.
Article
PubMed
Google Scholar
Manson JE, Hsia J, Johnson KC, Rossouw JE, Assaf AR, Lasser NL, Trevisan M, Black HR, Heckbert SR, Detrano R, et al. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med. 2003;349(6):523–34.
Article
CAS
PubMed
Google Scholar
Xing D, Nozell S, Chen YF, Hage F, Oparil S. Estrogen and mechanisms of vascular protection. Arterioscler Thromb Vasc Biol. 2009;29(3):289–95.
Article
CAS
PubMed
PubMed Central
Google Scholar