Fig. 1
Kaplan–Meier curves showing probability of survival in diabetic patients (a–c) and in diabetic patients with cardiovascular disease (d–f) with increased maximum D-dimer concentration (D-Dmax), or decreased rate of D-dimer (D-Drate) released during clot lysis, or increased peak thrombin generated, as compared with the remainder. Cut-offs were estimated based on the receiver operating curves. The D-Dmax > 4.26 mg/l was regarded as increased in all diabetic patients, while D-Dmax > 4.25 mg/l was regarded as increased in diabetic patients with cardiovascular disease; in both groups D-Drate < 0.07 mg/l/min was considered to be decreased, and peak thrombin > 283.5 nM was regarded as increased. P-values were calculated in the Mantel-Cox test