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Table 4 Blood metabolites correlated with blood lipids and serum Hp levels in non-DM subjects

From: Association between serum haptoglobin and carotid arterial functions: usefulness of a targeted metabolomics approach

Metabolites Total cholesterol Triglycerides HDL-C LDL-C Serum Hp Carotid IMT
Lyso-phosphatidylcholines (μM)
 LysoPC a C16:0 − 494.124 ± 89.651 39.362 ± 16.748 133.887 ± 36.720 310.854 ± 52.472 − 5.264 ± 2.417 25.137 ± 34.301
< 0.0001 0.0207 0.0004 <0.0001 0.0317 0.4653
 LysoPC a C17:0 − 3.953 ± 1.356 0.401 ± 0.253 1.140 ± 0.555 2.706 ± 0.793 − 0.088 ± 0.037 − 0.303 ± 0.519
0.0043 0.1160 0.0425 0.0009 0.0183 0.5606
 LysoPC a C18:2 52.100 ± 26.226 − 2.782 ± 4.899 − 0.547 ± 10.742 − 28.897 ± 15.350 − 1.675 ± 0.707 − 5.400 ± 10.034
0.0496 0.5714 0.9595 0.0626 0.0197 0.5916
 LysoPC a C24:0 − 1.237 ± 0.515 0.239 ± 0.096 0.724 ± 0.211 0.648 ± 0.301 − 0.031 ± 0.014 0.191 ± 0.197
0.0181 0.0145 0.0009 0.0339 0.0302 0.3344
Phosphatidylcholines (μM)
 PC ae C32:2 0.007 ± 0.463 0.029 ± 0.087 0.478 ± 0.190 0.114 ± 0.271 − 0.026 ± 0.012 − 0.229 ± 0.177
0.9886 0.7380 0.0133 0.6752 0.0390 0.2000
 PC ae C34:0 − 0.158 ± 0.737 0.284 ± 0.138 0.666 ± 0.302 0.075 ± 0.431 − 0.041 ± 0.020 − 0.080 ± 0.282
0.8312 0.0418 0.0295 0.8621 0.0441 0.7761
 PC ae C34:3 15.585 ± 3.858 − 1.788 ± 0.721 1.492 ± 1.580 − 6.850 ± 2.258 − 0.230 ± 0.104 − 2.803 ± 1.476
0.0001 0.0148 0.3473 0.0031 0.0292 0.0605
 PC ae C36:2 29.048 ± 6.159 − 0.149 ± 1.151 − 2.674 ± 2.523 − 15.795 ± 3.605 − 0.338 ± 0.166 − 2.884 ± 2.356
< 0.0001 0.8969 0.2915 < 0.0001 0.0446 0.2238
 PC ae C40:1 2.153 ± 0.872 0.357 ± 0.163 0.862 ± 0.357 − 0.748 ± 0.510 − 0.074 ± 0.024 − 0.253 ± 0.334
0.0152 0.0306 0.0176 0.1456 0.0020 0.4491
Amino acids (μM)
 Gln 865.339 ± 430.321 − 124.218 ± 80.390 − 303.854 ± 176.254 − 428.871 ± 251.864 − 32.233 ± 11.602 − 127.624 ± 164.646
0.0469 0.1254 0.0877 0.0916 0.0065 0.4400
  1. Multiple linear regression analysis was used to perform the analysis after adjusting for age, sex and body mass index with total cholesterol, triglycerides, HDL-C, LDL-C, serum Hp level tertiles and carotid IMT as independent variables. β ± SE and P values are shown in table
  2. Non-DM non-diabetes mellitus, Hp haptoglobin, Gln Glutamine, HDL-C high-density lipoprotein-cholesterol, LDL-C low-density lipoprotein-cholesterol, IMT intima-media thickness
  3. P values < 0.05 are shown in italic