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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Sitagliptin improved glucose assimilation in detriment of fatty-acid utilization in experimental type-II diabetes: role of GLP-1 isoforms in Glut4 receptor trafficking

Fig. 3

Sitagliptin enhanced cardiac Glut4 in detriment of FAT/CD36 in GK rats. a Glut4, d Glut1 and e FAT/CD36 protein levels in cytosolic (c) and sarcolemmal (s) fractions from wistar, GK and GK-sitagliptin myocardia. b Glut4 and f FAT/CD36 mRNA expression in the model. c phospho-Akt473 (dotted bars) and phospho-AMPKα496 (plain bars) protein expression in these hearts. *p < 0.05 and **p < 0.01 vs. cytosolic isoform or wistar rats. †p < 0.05 vs. GK rats or sarcolemmal isoform in wistar. N = 8, each group

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Cardiovascular Diabetology

ISSN: 1475-2840