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Table 4 Isolated papillary muscle data at 2.50 mM extracellular Ca2+ concentration

From: Rutin administration attenuates myocardial dysfunction in diabetic rats

Parameters C (n = 10) C-R (n = 13) DM (n = 13) DM-R (n = 12)
DT (g/mm2) 5.83 ± 0.86 6.57 ± 2.02 7.00 ± 0.85 6.49 ± 0.66
TPT (ms) 148.23 ± 7.45 146.92 ± 8.07 195.12 ± 8.07* 168.33 ± 14.39
RT1/2 159.86 ± 29.59 169.76 ± 14.17 224.62 ± 5.27* 213.43 ± 26.45#
+dT/dt (g/mm2/s) 59.54 ± 9.53 72.65 ± 21.22 66.65 ± 7.71 69.07 ± 11.14
−dT/dt (g/mm2/s) 25.53 ± 4.75 26.93 ± 7.02 23.28 ± 4.25 21.98 ± 3.16
CSA 0.961 ± 0.194 0.962 ± 0.294 0.889 ± 0.140 0.951 ± 0.144
  1. Data are expressed as mean ± standard deviation. One-way ANOVA in a factorial design 2 × 2 and Tukey’s post hoc test.
  2. C untreated rats, C-R rutin-treated rats, DM untreated diabetic rats, DM-R rutin-treated diabetic rats, DT peak of developed tension, TPT time to peak of tension, RT 1/2 time from peak tension to 50% relaxation, +dT/dt maximum rate of tension development, −dT/dt maximum rate of tension decline, CSA papillary muscle cross-sectional area.
  3. * p < 0.05 vs C; #p < 0.05 vs C-R; §p < 0.05 vs DM.