Rutin administration attenuates myocardial dysfunction in diabetic rats

Table 4 Isolated papillary muscle data at 2.50 mM extracellular Ca²⁺ concentration

Parameters	C (n = 10)	C-R (n = 13)	DM (n = 13)	DM-R (n = 12)
DT (g/mm²)	5.83 ± 0.86	6.57 ± 2.02	7.00 ± 0.85	6.49 ± 0.66
TPT (ms)	148.23 ± 7.45	146.92 ± 8.07	195.12 ± 8.07*	168.33 ± 14.39^#§
RT_1/2	159.86 ± 29.59	169.76 ± 14.17	224.62 ± 5.27*	213.43 ± 26.45^#
+dT/dt (g/mm²/s)	59.54 ± 9.53	72.65 ± 21.22	66.65 ± 7.71	69.07 ± 11.14
−dT/dt (g/mm²/s)	25.53 ± 4.75	26.93 ± 7.02	23.28 ± 4.25	21.98 ± 3.16
CSA	0.961 ± 0.194	0.962 ± 0.294	0.889 ± 0.140	0.951 ± 0.144

Data are expressed as mean ± standard deviation. One-way ANOVA in a factorial design 2 × 2 and Tukey’s post hoc test.
C untreated rats, C-R rutin-treated rats, DM untreated diabetic rats, DM-R rutin-treated diabetic rats, DT peak of developed tension, TPT time to peak of tension, RT _1/2 time from peak tension to 50% relaxation, +dT/dt maximum rate of tension development, −dT/dt maximum rate of tension decline, CSA papillary muscle cross-sectional area.
* p < 0.05 vs C; ^#p < 0.05 vs C-R; ^§p < 0.05 vs DM.

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