Chromosome 9p21.3 polymorphism in a Chinese Han population is associated with angiographic coronary plaque progression in non-diabetic but not in type 2 diabetic patients

Table 3 Changes in biochemical and angiographic measurements during follow-up

	Rs1333049
	GG (n = 122)	GC (n = 200)	CC (n = 108)	p
Change of Biochemical measurements
Total cholesterol (mmol/L)	0.64 ± 1.17	0.41 ± 1.12	0.53 ± 1.14	0.228
LDL-C (mmol/L)	0.27 ± 0.98	0.24 ± 0.90	0.34 ± 0.86	0.623
HDL-C (mmol/L)	-0.05 ± 0.49	-0.01 ± 0.22	0.01 ± 0.19 ^a	0.422
Triglyceride (mmol/L)	0.41 ± 1.92	0.10 ± 0.86 ^a	0.16 ± 1.06 ^b	0.106
apoA (g/L)	0.10 ± 0.15	0.09 ± 0.17	0.08 ± 0.16	0.029
apoB (g/L)	0.41 ± 0.37	0.39 ± 0.30	0.40 ± 0.34	0.639
Lipoprotein (a) (g/L)	-0.01 ± 0.08	-0.02 ± 0.09	-0.01 ± 0.12	0.873
Fast glucose (mmol/L)	0.39 ± 1.22	0.42 ± 2.48	0.66 ± 1.58	0.487
HbA_1c (%)	0.52 ± 1.54	0.40 ± 1.32	0.27 ± 1.44	0.419
White blood cells (× 10 ⁹/L)	0.75 ± 2.02	0.92 ± 1.94 ^a	1.46 ± 1.87 ^a	0.012
Neutrophile (× 10 ⁹/L)	0.51 ± 1.64	0.66 ± 1.98	1.13 ± 1.80 ^a	0.025
Lymphocyte (× 10 ⁹/L)	0.21 ± 0.66	0.21 ± 0.64	0.29 ± 0.54	0.463
Smoking status
Non-smoker (%)	67 (54.9%)	109 (54.5%)	54 (49.2%)	0.309
Smoker with cessation (%)	30 (24.6%)	49 (24.5%)	30 (27.7%)	0.474
Smoker without cessation (%)	25 (20.5%)	42 (21.0%)	24 (23.1%)	0.532
Angiographic features
New coronary lesion	0.09 ± 0.29	0.07 ± 0.26	0.11 ± 0.32	0.385
Change of MLD (mm)	0.18 ± 0.46	0.26 ± 0.44	0.29 ± 0.50	0.151
Change of diameter stenosis (%)	-5.14 ± 15.87	-8.82 ± 16.03	-9.38 ± 14.89	0.081
Coronary artery score (mm)	0.05 ± 0.03	0.16 ± 0.07	0.21 ± 0.11	0.188
Cumulative coronary obstruction	-0.03 ± 0.09	-0.20 ± 0.13	-0.31 ± 0.21	0.076

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