Mean change (LS mean) in HbA
from baseline to time of visit. Mean changes (LS mean and 95% CI) in HbA1c from baseline to time of visit for each treatment group (placebo, tofogliflozin 10, 20 or 40 mg) in the FAS (with LOCF) were plotted. Mean change from baseline in HbA1c at week 24 (LS mean) and LS mean difference versus placebo are shown in the table below the graph. LS means, LS mean differences and 95% CI were estimated using an ANCOVA model with treatment groups (placebo and tofogliflozin 10, 20, or 40 mg) as a fixed effect and baseline HbA1c and gender as covariates.