Cardiovascular Diabetology's 15th anniversary collection

The 20 most influential articles

How hyperglycemia promotes atherosclerosis: molecular mechanisms
Doron Aronson and Elliot J Rayfield
Published in 2002 with nearly 70,000 article accesses and 140 citations

Oxidative stress and the use of antioxidants in diabetes: Linking basic science to clinical practice
Jeanette Schultz Johansen, Alex K Harris, David J Rychly and Adviye Ergul
Published in 2005 with nearly 50,000 article accesses and over 280 citations

Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons
Alexander Tenenbaum, Michael Motro and Enrique Z Fisman
Published in 2005 with nearly 18,000 article accesses and over 100 citations

Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease
Adam R Baker, Nancy F da Silva, David W Quinn, Alison L Harte, Domenico Pagano, Robert S Bonser, Sudhesh Kumar and Philip G McTernan
Published in 2006 with over 15,400 article accesses and 250 citations

Endothelial dysfunction: a comprehensive appraisal
Ricardo J Esper, Roberto A Nordaby, Jorge O Vilariño, Antonio Paragano, José L Cacharrón and Rogelio A Machado
Published in 2006 with nearly 55,000 article accesses

Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study
Tommy Jönsson, Yvonne Granfeldt, Bo Ahrén, Ulla-Carin Branell, Gunvor Pålsson, Anita Hansson, Margareta Söderström and Staffan Lindeberg
Published in 2009 with nearly 80,000 article accesses and an Altmetric score of 345

Cardiovascular safety of exenatide BID: an integrated analysis from controlled clinical trials in participants with type 2 diabetes
Robert Ratner, Jenny Han, Dawn Nicewarner, Irina Yushmanova, Byron J Hoogwerf and Larry Shen
Published in 2011 with over 11,500 article accesses

Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: a pre-specified, prospective, and adjudicated meta-analysis of a phase 3 programme 
Odd Erik Johansen, Dietmar Neubacher, Maximilian von Eynatten, Sanjay Patel and Hans-Juergen Woerle
Published in 2012 with over 21,000 article accesses

Advanced glycation end products evoke endothelial cell damage by stimulating soluble dipeptidyl peptidase-4 production and its interaction with mannose 6-phosphate/insulin-like growth factor II receptor 
Yuji Ishibashi, Takanori Matsui, Sayaka Maeda, Yuichiro Higashimoto and Sho-ichi Yamagishi
Published in 2013 with 7,600 article accesses

Antagonistic effect of TNF-alpha and insulin on uncoupling protein 2 (UCP-2) expression and vascular damage
Almudena Gómez-Hernández, Liliana Perdomo, Natalia de las Heras, Nuria Beneit, Óscar Escribano, Yolanda F Otero, Carlos Guillén, Sabela Díaz-Castroverde, Beatriz Gozalbo-López, Victoria Cachofeiro, Vicente Lahera and Manuel Benito
Published in 2014 with over 36,000 article accesses

Hypertriglyceridemia: a too long unfairly neglected major cardiovascular risk factor
Alexander Tenenbaum, Robert Klempfner and Enrique Z Fisman
Published in 2014 with over 31,000 article accesses

Rationale, design, and baseline characteristics of a randomized, placebo-controlled cardiovascular outcome trial of empagliflozin (EMPA-REG OUTCOME™)
Bernard Zinman, Silvio E Inzucchi, John M Lachin, Christoph Wanner, Roberto Ferrari, David Fitchett, Erich Bluhmki, Stefan Hantel, Joan Kempthorne-Rawson, Jennifer Newman, Odd Erik Johansen, Hans-Juergen Woerle and Uli C Broedl
Published in 2014 with over 27,000 article accesses and an Altmetric score of 22

Adiponectin: a manifold therapeutic target for metabolic syndrome, diabetes, and coronary disease?
Enrique Z Fisman and Alexander Tenenbaum
Published in 2014 with over 2,600 article accesses

The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus
David ZI Cherney, Bruce A Perkins, Nima Soleymanlou, Ronnie Har, Nora Fagan, Odd Erik Johansen, Hans-Juergen Woerle, Maximilian von Eynatten and Uli C Broedl
Published in 2014 with over 8,000 article accesses

Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathway
Xuwei Hou, Zhaohui Hu, Hanying Xu, Jian Xu, Shunrong Zhang, Yigang Zhong, Xiuying He and Ningfu Wang
Published in 2014 with over 2,800 article accesses

Diastolic dysfunction in the diabetic continuum: association with insulin resistance, metabolic syndrome and type 2 diabetes
Ricardo Fontes-Carvalho, Ricardo Ladeiras-Lopes, Paulo Bettencourt, Adelino Leite-Moreira and Ana Azevedo
Published in 2015 with over 2,700 article accesses

Association among weight change, glycemic control, and markers of cardiovascular risk with exenatide once weekly: a pooled analysis of patients with type 2 diabetes
Lawrence Blonde, Richard Pencek and Leigh MacConell
Published in 2015 with over 2,300 article accesses

Effect of empagliflozin monotherapy on postprandial glucose and 24-hour glucose variability in Japanese patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled, 4-week study
Rimei Nishimura, Yuko Tanaka, Kazuki Koiwai, Kohei Inoue, Thomas Hach, Afshin Salsali, Søren S Lund and Uli C Broedl
Published in 2015 with over 4,600 article accesses

Cardiovascular effects of dapagliflozin in patients with type 2 diabetes and different risk categories: a meta-analysis
Christian Sonesson, Peter A. Johansson, Eva Johnsson and Ingrid Gause-Nilsson
Published in 2016 with over 16,500 article accesses

Vascular endothelial microparticles-incorporated microRNAs are altered in patients with diabetes mellitus
Felix Jansen, Han Wang, David Przybilla, Bernardo S. Franklin, Andreas Dolf, Philipp Pfeifer, Theresa Schmitz, Anna Flender, Elmar Endl, Georg Nickenig and Nikos Werner
Published in 2016 with over 1,200 article accesses