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  1. The use of abciximab (c7E3 Fab) or eptifibatide improves clinical outcomes in diabetics undergoing percutaneous coronary intervention. These β3 integrin inhibitors antagonize fibrinogen binding to αIIbβ3 integrin...

    Authors: Alokkumar Pathak, Renyi Zhao, Jianhua Huang and George A Stouffer
    Citation: Cardiovascular Diabetology 2008 7:36
    Content type: Original investigation Published on:

  2. Several aspects concerning the relationship between the metabolic syndrome and incident diabetes are incompletely understood including the magnitude of the risk estimate, potential gender differences in the as...

    Authors: Earl S Ford, Matthias B Schulze, Tobias Pischon, Manuela M Bergmann, Hans-Georg Joost and Heiner Boeing
    Citation: Cardiovascular Diabetology 2008 7:35
    Content type: Original investigation Published on:

  3. Different mechanisms of diabetic-induced NO dysfunction have been proposed and central to most of them are significant changes in eNOS function as the rate-limiting step in NO bioavailability. eNOS exists in b...

    Authors: James Grijalva, Steven Hicks, Xiangmin Zhao, Sushma Medikayala, Pawel M Kaminski, Michael S Wolin and John G Edwards
    Citation: Cardiovascular Diabetology 2008 7:34
    Content type: Original investigation Published on:

  4. We investigated the role of polyol pathway enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH) in mediating injury due to ischemia-reperfusion (IR) in Type 2 diabetic BBZ rat hearts. Specifically, w...

    Authors: Qing Li, Yuying C Hwang, Radha Ananthakrishnan, Peter J Oates, Dennis Guberski and Ravichandran Ramasamy
    Citation: Cardiovascular Diabetology 2008 7:33
    Content type: Original investigation Published on:

  5. In Sweden, diabetes prevalence is increasing in spite of unchanged incidence, indicating improved survival. In recent US studies mortality in diabetic subjects has decreased over three decades, but only in men...

    Authors: Mats Eliasson, Mats Talbäck and Måns Rosén
    Citation: Cardiovascular Diabetology 2008 7:32
    Content type: Original investigation Published on:

  6. Current guidelines from the European Society of Cardiology (ESC) define low thresholds for the diagnosis of dyslipidemia using total cholesterol (TC) and LDL-cholesterol (LDL-C) to guide treatment. Although be...

    Authors: Elisabeth Steinhagen-Thiessen, Peter Bramlage, Christian Lösch, Hans Hauner, Heribert Schunkert, Anja Vogt, Jürgen Wasem, Karl-Heinz Jöckel and Susanne Moebus
    Citation: Cardiovascular Diabetology 2008 7:31
    Content type: Original investigation Published on:

  8. Cardiovascular disease is the major cause of morbidity and mortality associated with diabetes. There is increasing evidence that advanced glycation endproducts (AGEs) play a pivotal role in atherosclerosis, in...

    Authors: Robbert Meerwaldt, Thera Links, Clark Zeebregts, Rene Tio, Jan-Luuk Hillebrands and Andries Smit
    Citation: Cardiovascular Diabetology 2008 7:29
    Content type: Review Published on:

  10. We examined, in a country of the African region, i) the prevalence of the metabolic syndrome (MetS) according to three definitions (ATP, WHO and IDF); ii) the distribution of the MetS criteria; iii) the level ...

    Authors: Clara Kelliny, Julita William, Walter Riesen, Fred Paccaud and Pascal Bovet
    Citation: Cardiovascular Diabetology 2008 7:27
    Content type: Original investigation Published on:

  11. The role of structural and functional abnormalities of small vessels in diabetes cardiomyopathy remains unclear. Myocardial contrast echocardiography allows the quantification of myocardial blood flow at rest ...

    Authors: Bernard Cosyns, Steven Droogmans, Sophie Hernot, Céline Degaillier, Christian Garbar, Caroline Weytjens, Bram Roosens, Danny Schoors, Tony Lahoutte, Philippe R Franken and Guy Van Camp
    Citation: Cardiovascular Diabetology 2008 7:26
    Content type: Original investigation Published on:

  12. Anaemia has been shown in previous studies to be a risk factor for cardiovascular disease in diabetic patients with chronic kidney disorder. This study was aimed to assess the prevalence of anaemia and kidney ...

    Authors: Chidum E Ezenwaka, Altheia Jones-LeCointe, Emeka Nwagbara, Dawn Seales and Fidelis Okali
    Citation: Cardiovascular Diabetology 2008 7:25
    Content type: Original investigation Published on:

  13. Exenatide belongs to a new therapeutic class in the treatment of diabetes (incretin mimetics), allowing glucose-dependent glycaemic control in Type 2 diabetes. Randomised controlled trial data suggest that exe...

    Authors: Anette Woehl, Mark Evans, Anthony P Tetlow and Philip McEwan
    Citation: Cardiovascular Diabetology 2008 7:24
    Content type: Original investigation Published on:

  14. Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed.

    Authors: María E Sáez, Antonio Grilo, Francisco J Morón, Luis Manzano, María T Martínez-Larrad, Antonio González-Pérez, Javier Serrano-Hernando, Agustín Ruiz, Reposo Ramírez-Lorca and Manuel Serrano-Ríos
    Citation: Cardiovascular Diabetology 2008 7:23
    Content type: Original investigation Published on:

  15. Recent clinical trials reported conflicting results on the reduction of new-onset diabetes using RAS blocking agents. Therefore the role of these agents in preventing diabetes is still not well defined. Ramipr...

    Authors: Walter Zidek, Joachim Schrader, Stephan Lüders, Stephan Matthaei, Christoph Hasslacher, Joachim Hoyer, Peter Bramlage, Claus-Dieter Sturm and W Dieter Paar
    Citation: Cardiovascular Diabetology 2008 7:22
    Content type: Original investigation Published on:

  16. There is currently much interest in encouraging individuals to increase physical activity in order to reduce CVD risk. This study has been designed to determine if personalised CVD risk appreciation can increa...

    Authors: Hermione C Price, Lynne Tucker, Simon J Griffin and Rury R Holman
    Citation: Cardiovascular Diabetology 2008 7:21
    Content type: Study protocol Published on:

  17. The metabolic deregulation associated with diabetes mellitus (DM) causes secondary pathophysiologic changes in multiple organ systems. Endothelial injury is induced by oxidative stress (OS) and inflammation. W...

    Authors: Raymond Farah, Revital Shurtz-Swirski and Olga Lapin
    Citation: Cardiovascular Diabetology 2008 7:20
    Content type: Original investigation Published on:

  19. Epidemiologic studies have suggested that hypertriglyceridemia and insulin resistance are related to the development of colon cancer. Nuclear peroxisome proliferator-activated receptors (PPAR), which play a ce...

    Authors: Alexander Tenenbaum, Valentina Boyko, Enrique Z Fisman, Ilan Goldenberg, Yehuda Adler, Micha S Feinberg, Michael Motro, David Tanne, Joseph Shemesh, Ehud Schwammenthal and Solomon Behar
    Citation: Cardiovascular Diabetology 2008 7:18
    Content type: Original investigation Published on:

  21. The large clinical trials proved that Basal-Bolus (BB) insulin therapy was effective in the prevention of diabetic complications and their progression. However, BB therapy needs multiple insulin injections per...

    Authors: Yumi Miyashita, Rimei Nishimura, Masami Nemoto, Toru Matsudaira, Hideaki Kurata, Tamotsu Yokota, Kuninobu Yokota, Katsuyoshi Tojo, Kazunori Utsunomiya and Naoko Tajima
    Citation: Cardiovascular Diabetology 2008 7:16
    Content type: Original investigation Published on:

  22. In comparison to the well established changes in compliance that occur at the large vessel level in diabetes, much less is known about the changes in compliance of the cardiovascular system at the end-organ le...

    Authors: Richard J MacIsaac, Merlin C Thomas, Sianna Panagiotopoulos, Trudy J Smith, Huming Hao, D Geoffrey Matthews, George Jerums, Louise M Burrell and Piyush M Srivastava
    Citation: Cardiovascular Diabetology 2008 7:15
    Content type: Original investigation Published on:

  23. Epidemiological studies have revealed a relationship between early growth restriction and the subsequent development of insulin resistance and type 2 diabetes. Ligation of the uterine arteries in rats mimics u...

    Authors: Daniela Germani, Antonella Puglianiello and Stefano Cianfarani
    Citation: Cardiovascular Diabetology 2008 7:14
    Content type: Original investigation Published on:

  24. Diabetes has negative, and exercise training positive, effects on the skeletal muscle vasculature, but the mechanisms are not yet fully understood. In the present experiment the effects of running exercise on ...

    Authors: Riikka Kivelä, Mika Silvennoinen, Maarit Lehti, Sanni Jalava, Veikko Vihko and Heikki Kainulainen
    Citation: Cardiovascular Diabetology 2008 7:13
    Content type: Original investigation Published on:

  27. Hypertension and type 2 diabetes are common co-morbidities. Preliminary studies suggest that thiazolidinediones reduce blood pressure (BP). We therefore used ambulatory BP to quantify BP lowering at 6–12 month...

    Authors: Michel Komajda, Paula Curtis, Markolf Hanefeld, Henning Beck-Nielsen, Stuart J Pocock, Andrew Zambanini, Nigel P Jones, Ramon Gomis and Philip D Home
    Citation: Cardiovascular Diabetology 2008 7:10
    Content type: Original investigation Published on:

  28. There are no risk scores available for predicting heart failure in Type 2 diabetes mellitus (T2DM). Based on the Hong Kong Diabetes Registry, this study aimed to develop and validate a risk score for predictin...

    Authors: Xilin Yang, Ronald C Ma, Wing-Yee So, Alice P Kong, Gary T Ko, Chun-Shun Ho, Christopher W Lam, Clive S Cockram, Peter C Tong and Juliana C Chan
    Citation: Cardiovascular Diabetology 2008 7:9
    Content type: Original investigation Published on:

  29. An authentic survey of the transcript-level response of the diabetic endothelium in vivo is key to understanding diabetic cardiovascular complications such as accelerated atherosclerosis and endothelial dysfun...

    Authors: J Gregory Maresh and Ralph V Shohet
    Citation: Cardiovascular Diabetology 2008 7:8
    Content type: Original investigation Published on:

  32. The rs9939609 T>A single-nucleotide polymorphism (SNP) in the FTO gene has previously been found to be associated with obesity in European Caucasian samples. The objective of this study is to examine whether this...

    Authors: Salam A Al-Attar, Rebecca L Pollex, Matthew R Ban, T Kue Young, Peter Bjerregaard, Sonia S Anand, Salim Yusuf, Bernard Zinman, Stewart B Harris, Anthony JG Hanley, Philip W Connelly, Murray W Huff and Robert A Hegele
    Citation: Cardiovascular Diabetology 2008 7:5
    Content type: Original investigation Published on:

  33. The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been reported to be as closely correlated with insulin resistance as is the fasting serum insulin concentration (FSI), and therefor...

    Authors: Chaoyang Li, Earl S Ford, Yuan-Xiang Meng, Ali H Mokdad and Gerald M Reaven
    Citation: Cardiovascular Diabetology 2008 7:4
    Content type: Original investigation Published on:

  34. Thiazolidinediones exert anti-inflammatory and anti-oxidative roles and attenuate atherosclerosis by mechanisms partially independent of their metabolizing actions. High doses of angiotensin type 1 receptor (AT1R...

    Authors: Y Hernandez-Trujillo, F Rodriguez-Esparragon, A Macias-Reyes, A Caballero-Hidalgo and Jose C Rodriguez-Perez
    Citation: Cardiovascular Diabetology 2008 7:3
    Content type: Original investigation Published on:

  35. Activation of the diacylglycerol (DAG)-protein kinase C (PKC) pathway has been implicated in the pathogenesis of a number of diabetic complications. Diacylglycerol kinase (DGK) converts DAG to phosphatidic aci...

    Authors: Olga Bilim, Yasuchika Takeishi, Tatsuro Kitahara, Takanori Arimoto, Takeshi Niizeki, Toshiki Sasaki, Kaoru Goto and Isao Kubota
    Citation: Cardiovascular Diabetology 2008 7:2
    Content type: Original investigation Published on:

  36. Aortic distensibility (AD) is a marker of the elastic properties of the aorta. Reduction of AD occurs early in subjects with type 2 diabetes mellitus (T2DM) and it is associated with subclinical generalized at...

    Authors: Nicholas Tentolouris, Athanasia Papazafiropoulou, Ioannis Moyssakis, Stavros Liatis, Despoina Perrea, Maria Kostakis and Nicholas Katsilambros
    Citation: Cardiovascular Diabetology 2008 7:1
    Content type: Original investigation Published on:

  37. Intensive insulin therapy to maintain normoglycemia after cardiac surgery reduces morbidity and mortality. We investigated the magnitude and duration of hyperglycemia caused by dexamethasone administered after...

    Authors: Mathijs Vogelzang, Miriam Hoekstra, José T Drost, Marcel Janse, Iwan CC van der Horst, Piet W Boonstra, Felix Zijlstra, Bert G Loef and Maarten WN Nijsten
    Citation: Cardiovascular Diabetology 2007 6:39
    Content type: Original investigation Published on:

  38. The aim of the present study was to investigate the relationship between speed during maximum exercise test (ET) and oxygen consumption (VO2) in control and STZ-diabetic rats, in order to provide a useful method ...

    Authors: Bruno Rodrigues, Diego M Figueroa, Cristiano T Mostarda, Marcelo V Heeren, Maria-Cláudia Irigoyen and Kátia De Angelis
    Citation: Cardiovascular Diabetology 2007 6:38
    Content type: Methodology Published on:

  39. Glycated haemoglobin (HbA1c), blood pressure and body mass index (BMI) are risk factors for albuminuria, the latter in turn can lead to hyperlipidaemia. We used novel statistical analyses to examine how albuminur...

    Authors: Xilin Yang, Ronald C Ma, Wing-Yee So, Gary T Ko, Alice P Kong, Christopher W Lam, Chun-Shun Ho, Clive S Cockram, Vivian C Wong, Peter C Tong and Juliana C Chan
    Citation: Cardiovascular Diabetology 2007 6:37
    Content type: Original investigation Published on:

  40. A number of intervention studies have shown that therapy with angiotensin receptor blockers, such as irbesartan, can improve metabolic parameters and reduce the incidence of diabetes mellitus. It is unknown wh...

    Authors: Klaus G Parhofer, Felix Münzel and Michael Krekler
    Citation: Cardiovascular Diabetology 2007 6:36
    Content type: Original investigation Published on:

  41. We have reviewed the impact of the ubiquitin proteasome system (UPS) on atherosclerosis progression of diabetic patients. A puzzle of many pieces of evidence suggests that UPS, in addition to its role in the r...

    Authors: Raffaele Marfella, Michele D' Amico, Clara Di Filippo, Mario Siniscalchi, Ferdinando Carlo sasso, Franca Ferraraccio, Francesco Rossi and Giuseppe Paolisso
    Citation: Cardiovascular Diabetology 2007 6:35
    Content type: Hypothesis Published on:

  42. Congenital heart defects are frequently observed in infants of diabetic mothers, but the molecular basis of the defects remains obscure. Thus, the present study was performed to gain some insights into the mol...

    Authors: Srinivasan Dinesh Kumar, S Thameem Dheen and Samuel Sam Wah Tay
    Citation: Cardiovascular Diabetology 2007 6:34
    Content type: Original investigation Published on:

  43. Inhibition of vascular smooth muscle cell (vSMC) proliferation by oral anti-hyperglycemic agents may have a role to play in the amelioration of vascular disease in diabetes. Thiazolidinediones (TZDs) inhibit v...

    Authors: Peter J Little, Narin Osman, Stephanie T de Dios, Nelly Cemerlang, Mandy Ballinger and Julie Nigro
    Citation: Cardiovascular Diabetology 2007 6:33
    Content type: Original investigation Published on:

  44. Impaired glucose regulation (IGR) is associated with detrimental cardiovascular outcomes such as cardiovascular disease risk factors (CVD risk factors) or intima-media thickness (IMT). Our aim was to examine w...

    Authors: David Faeh, Julita William, Patrick Yerly, Fred Paccaud and Pascal Bovet
    Citation: Cardiovascular Diabetology 2007 6:32
    Content type: Original investigation Published on:

  45. Because of previously reported ethnic differences in determinants and markers of obesity and related metabolic disorders, we sought to investigate circulating levels of adiponectin and their correlates in a su...

    Authors: Eugène Sobngwi, Valery Effoe, Philippe Boudou, Dieudonné Njamen, Jean-François Gautier and Jean-Claude Mbanya
    Citation: Cardiovascular Diabetology 2007 6:31
    Content type: Original investigation Published on:

  46. Recent studies have suggested that diabetes mellitus (DM) may cause left ventricular (LV) dysfunction directly resulting in increased susceptibility to heart failure. Using pinhole collimators and advances in ...

    Authors: Bernard Cosyns, Steven Droogmans, Caroline Weytjens, Tony Lahoutte, Guy Van Camp, Danny Schoors and Philippe R Franken
    Citation: Cardiovascular Diabetology 2007 6:30
    Content type: Original investigation Published on:

  47. Women with PCOS have been reported to be at increased risk of a number of gynaecological neoplasias, including endometrial, breast, and ovarian cancer. Studies of the possible association of genetic variation ...

    Authors: Muammer Karadeniz, Mehmet Erdogan, Afig Berdeli, Sadik Tamsel, Fusun Saygili and Candeger Yilmaz
    Citation: Cardiovascular Diabetology 2007 6:29
    Content type: Original investigation Published on:

  48. The Study of Micardis (telmisartan) in Overweight/Obese patients with Type 2 diabetes and Hypertension (SMOOTH) compared hydrochlorothiazide (HCTZ) plus telmisartan or valsartan fixed-dose combination therapie...

    Authors: Arya M Sharma, Jaime Davidson, Stephen Koval and Yves Lacourcière
    Citation: Cardiovascular Diabetology 2007 6:28
    Content type: Original investigation Published on:

  49. Since visceral fat tissue is known to release various inflammatory and anti-inflammatory cytokines, abdominal obesity may play a key role in the inflammation associated with metabolic syndrome (MetS). However,...

    Authors: Makoto Nishida, Toshiki Moriyama, Yoshiro Sugita and Keiko Yamauchi-Takihara
    Citation: Cardiovascular Diabetology 2007 6:27
    Content type: Original investigation Published on:

  50. A beneficial effect on glucose metabolism is reported with angiotensin receptor blocker (ARB) treatment of hypertension. The effect on blood glucose level during the course of treatment with ARBs in clinical c...

    Authors: Noboru Kitamura, Yasuo Takahashi, Shuukoh Yamadate and Satoshi Asai
    Citation: Cardiovascular Diabetology 2007 6:26
    Content type: Original investigation Published on:
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