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  1. Disorders of endocrine substances in epicardial adipose tissue are known causes of coronary artery disease (CAD). Adiponectin is associated with cardiovascular disease. However, expression of adiponectin in ep...

    Authors: Yuan Zhou, Yutao Wei, Lei Wang, Xianguo Wang, Xinling Du, Zongquan Sun, Nianguo Dong and Xinzhong Chen
    Citation: Cardiovascular Diabetology 2011 10:2
    Content type: Original investigation Published on:

  2. To estimate the incidence of complications, life expectancy and diabetes related mortality in the Mexican diabetic population over the next two decades using data from a nation-wide, population based survey an...

    Authors: Nancy Reynoso-Noverón, Roopa Mehta, Paloma Almeda-Valdes, Rosalba Rojas-Martinez, Salvador Villalpando, Mauricio Hernández-Ávila and Carlos A Aguilar-Salinas
    Citation: Cardiovascular Diabetology 2011 10:1
    Content type: Original investigation Published on:

  3. Diabetes mellitus counts as a major risk factor for developing atherosclerosis. The activation of protein kinase C (PKC) is commonly known to take a pivotal part in the pathogenesis of atherosclerosis, though ...

    Authors: Dieter Paul Hoyer, Yüksel Korkmaz, Sabine Grönke, Klaus Addicks, Nina Wettschureck, Stefan Offermanns and Hannes Reuter
    Citation: Cardiovascular Diabetology 2010 9:93
    Content type: Original investigation Published on:

  4. There is debate as to whether the association between C-reactive protein (CRP) and insulin resistance is independent of body fatness, particularly central obesity. Therefore, the association among CRP, insulin...

    Authors: Bin Lu, Yehong Yang, Zhihong Yang, Xiaocheng Feng, Xuanchun Wang, Zhaoyun Zhang and Renming Hu
    Citation: Cardiovascular Diabetology 2010 9:92
    Content type: Original investigation Published on:

  5. Plaque morphology directly correlates with risk of embolism and the recently developed dual-source computed tomography angiography (DSCTA) may help to detect plaques more precisely. The aim of our study was to...

    Authors: Ci He, Zhi-gang Yang, Zhi-gang Chu, Zhi-hui Dong, Heng Shao, Wen Deng, Jing Chen, Li-qing Peng, Si-shi Tang and Jia-he Xiao
    Citation: Cardiovascular Diabetology 2010 9:91
    Content type: Original investigation Published on:

  6. Endothelial inflammatory responses mediated by Toll-like receptors (TLRs), particularly TLR2 and TLR4, play an important role in atherogenesis. While Type 1 diabetes (T1D) promotes the development and progress...

    Authors: Jilin Li, Chunhua Jin, Joseph C Cleveland Jr, Lihua Ao, Dingli Xu, David A Fullerton and Xianzhong Meng
    Citation: Cardiovascular Diabetology 2010 9:90
    Content type: Original investigation Published on:

  7. The aim of the present study was to verify whether BNP might detect pre-clinical diastolic dysfunction (LVDD) in type-2 diabetic patients.

    Authors: Silvio Romano, Michele Di Mauro, Simona Fratini, Leonello Guarracini, Fabrizio Guarracini, Gianfranco Poccia and Maria Penco
    Citation: Cardiovascular Diabetology 2010 9:89
    Content type: Original investigation Published on:

  8. T2DM is associated with atherogenic dyslipidemia (AD), defined as decreased HDL-C plus raised triglycerides (TG). AD confers increased risk for CAD, even when LDL-C is at target. AD is rarely assessed due to l...

    Authors: Michel P Hermans, Sylvie A Ahn and Michel F Rousseau
    Citation: Cardiovascular Diabetology 2010 9:88
    Content type: Original investigation Published on:

  9. Metabolic syndrome (MetS) is associated with an increased risk of major cardiovascular events. Increased high-sensitivity C-reactive protein (hsCRP) levels are associated with MetS and its components. Changes ...

    Authors: Ryuichi Kawamoto, Yasuharu Tabara, Katsuhiko Kohara, Tetsuro Miki, Tomo Kusunoki, Shuzo Takayama, Masanori Abe, Tateaki Katoh and Nobuyuki Ohtsuka
    Citation: Cardiovascular Diabetology 2010 9:87
    Content type: Original investigation Published on:

  10. Low grade inflammation is of pathogenic importance in atherosclerosis and in the development of cardiovascular disease (CVD) and type 2 diabetes (T2D). Matrix GLA protein (MGP), an inhibitor of medial calcific...

    Authors: Stine B Thomsen, Camilla N Rathcke, Bo Zerahn and Henrik Vestergaard
    Citation: Cardiovascular Diabetology 2010 9:86
    Content type: Original investigation Published on:

  11. Insulin resistance (IR) has been associated with cardiovascular diseases (CVD). Heart rate variability (HRV), an index of cardiac autonomic modulation (CAM), is also associated with CVD mortality and CVD morbi...

    Authors: Sol M Rodríguez-Colón, Xian Li, Michele L Shaffer, Fan He, Edward O Bixler, Alexandros N Vgontzas, Jianwen Cai and Duanping Liao
    Citation: Cardiovascular Diabetology 2010 9:85
    Content type: Original investigation Published on:

  12. To investigate whether the known diabetes mellitus (KDM) or newly diagnosed diabetes mellitus (NDM) could be regarded as a coronary heart disease (CHD) risk equivalent among a relatively young Middle East popu...

    Authors: Farzad Hadaegh, Nooshin Fahimfar, Davood Khalili, Farhad Sheikholeslami and Fereidoun Azizi
    Citation: Cardiovascular Diabetology 2010 9:84
    Content type: Original investigation Published on:

  13. Notwithstanding previous studies supporting independent associations between obstructive sleep apnea (OSA) and prevalence of diabetes, the underlying pathogenesis of impaired glucose regulation in OSA remains ...

    Authors: Maria Pallayova, Kimberley E Steele, Thomas H Magnuson, Michael A Schweitzer, Nathan R Hill, Shannon Bevans-Fonti and Alan R Schwartz
    Citation: Cardiovascular Diabetology 2010 9:83
    Content type: Original investigation Published on:

  14. Azelnidipine (AZL), a long-acting dihydropyridine-based calcium antagonist, has been recently approved and used for treating ischemic heart disease and cardiac remodeling after myocardial infarction, however, ...

    Authors: Vasundhara Kain, Sandeep Kumar, Amrutesh S Puranik and Sandhya L Sitasawad
    Citation: Cardiovascular Diabetology 2010 9:82
    Content type: Original investigation Published on:

  15. Higher walking levels lead to lower mortality in type 2 diabetes, but inclement weather may reduce walking. In this patient population, we conducted a longitudinal cohort study to objectively quantify seasonal...

    Authors: Kaberi Dasgupta, Lawrence Joseph, Louise Pilote, Ian Strachan, Ron J Sigal and Cathy Chan
    Citation: Cardiovascular Diabetology 2010 9:81
    Content type: Original investigation Published on:

  16. Diabetics have high prevalence of subclinical coronary artery disease (CAD) with typical characteristics (diffuse disease, large calcifications). Although 64-slice multidetector computed tomography (MDCT) coro...

    Authors: Daniele Andreini, Gianluca Pontone, Antonio L Bartorelli, Piergiuseppe Agostoni, Saima Mushtaq, Laura Antonioli, Sarah Cortinovis, Mauro Canestrari, Andrea Annoni, Giovanni Ballerini, Cesare Fiorentini and Mauro Pepi
    Citation: Cardiovascular Diabetology 2010 9:80
    Content type: Original investigation Published on:

  17. Recent studies revealed that glucokinase regulatory protein (GCKR) variants (rs780094 and rs1260326) are associated with serum triglycerides and plasma glucose levels. Here we analyzed primarily the associatio...

    Authors: Márton Mohás, Péter Kisfali, Luca Járomi, Anita Maász, Eszter Fehér, Veronika Csöngei, Noémi Polgár, Enikő Sáfrány, Judit Cseh, Katalin Sümegi, Katalin Hetyésy, István Wittmann and Béla Melegh
    Citation: Cardiovascular Diabetology 2010 9:79
    Content type: Original investigation Published on:

  18. The various autonomic control systems lead to characteristic changes in heart rate (HR) and blood pressure (BP) during acute hemorrhage. However, cardiovascular autonomic neuropathy due to diabetes mellitus ma...

    Authors: Aiji Boku, Mitsutaka Sugimura, Yoshinari Morimoto, Hiroshi Hanamoto and Hitoshi Niwa
    Citation: Cardiovascular Diabetology 2010 9:78
    Content type: Original investigation Published on:

  19. Dyslipidaemia is an important but modifiable risk factor of cardiovascular disease (CVD) in type 2 diabetes. Yet, the effectiveness of lipid regulating drugs in Asians is lacking. We examined the effects of li...

    Authors: Rose ZW Ting, Xilin Yang, Linda WL Yu, Andrea OY Luk, Alice PS Kong, Peter CY Tong, Wing-Yee So, Juliana CN Chan and Ronald CW Ma
    Citation: Cardiovascular Diabetology 2010 9:77
    Content type: Original investigation Published on:

  20. Accumulating evidence suggests glucagon-like peptide-1 (GLP-1) exerts cardioprotective effects in animal models of myocardial infarction (MI). We hypothesized that chronic treatment with GLP-1 or the exenatide...

    Authors: Que Liu, Christen Anderson, Anatoly Broyde, Clara Polizzi, Rayne Fernandez, Alain Baron and David G Parkes
    Citation: Cardiovascular Diabetology 2010 9:76
    Content type: Original investigation Published on:

  21. Diabetes mellitus (DM) and impaired glucose tolerance (IGT) are risk factors for acute myocardial infarction (AMI). However, it is unknown whether hyperglycemic state is associated with increased major adverse...

    Authors: Shuichi Kitada, Yoritaka Otsuka, Nobuaki Kokubu, Yoichiro Kasahara, Yu Kataoka, Teruo Noguchi, Yoichi Goto, Genjirou Kimura and Hiroshi Nonogi
    Citation: Cardiovascular Diabetology 2010 9:75
    Content type: Original investigation Published on:

  22. Coronary artery disease (CAD) is a common and severe complication of type 2 diabetes mellitus (DM). The aim of this study is to identify the features of CAD in diabetic patients using coronary CT angiography (...

    Authors: Zhi-gang Chu, Zhi-gang Yang, Zhi-hui Dong, Zhi-yu Zhu, Li-qing Peng, Heng Shao, Ci He, Wen Deng, Si-shi Tang and Jing Chen
    Citation: Cardiovascular Diabetology 2010 9:74
    Content type: Original investigation Published on:

  23. Insulin resistance is associated with a proinflammatory state that promotes the development of complications such as type 2 diabetes mellitus (T2DM) and atherosclerosis. The metabolic stimuli that initiate and...

    Authors: Robert C Bunn, Gael E Cockrell, Yang Ou, Kathryn M Thrailkill, Charles K Lumpkin Jr and John L Fowlkes
    Citation: Cardiovascular Diabetology 2010 9:73
    Content type: Original investigation Published on:

  24. Informations about the effects of intense exercise training on diabetes-induced myocardial dysfunctions are lacking. We have examined the effects of intense exercise training on the cardiac function of diabeti...

    Authors: Solène Le Douairon Lahaye, Arlette Gratas-Delamarche, Ludivine Malardé, Sophie Vincent, Mohamed Sami Zguira, Sophie Lemoine Morel, Paul Delamarche, Hassane Zouhal, François Carré and Françoise Rannou Bekono
    Citation: Cardiovascular Diabetology 2010 9:72
    Content type: Original investigation Published on:

  25. Baboons (Papio hamadryas Sp.) develop features of the cardiometabolic syndrome and represent a clinically-relevant animal model in which to study the aetiology of the disorder. To further evaluate the baboon as a...

    Authors: Paul B Higgins, Raul A Bastarrachea, Juan Carlos Lopez-Alvarenga, Maggie Garcia-Forey, J Michael Proffitt, V Saroja Voruganti, M Elizabeth Tejero, Vicki Mattern, Karin Haack, Robert E Shade, Shelley A Cole and Anthony G Comuzzie
    Citation: Cardiovascular Diabetology 2010 9:71
    Content type: Original investigation Published on:

  26. The aim of the present cross-sectional study was to assess possible associations between osteopontin (OPN), and thrombin-cleaved (N-half) OPN, and nephropathy and coronary artery disease (CAD) in patients with...

    Authors: Xiaoxiang Yan, Motoaki Sano, Lin Lu, Wei Wang, Qi Zhang, Ruiyan Zhang, Lingjie Wang, Qiujing Chen, Keiichi Fukuda and Weifeng Shen
    Citation: Cardiovascular Diabetology 2010 9:70
    Content type: Original investigation Published on:

  27. Epidemiological evidence suggests that fibrinogen and CRP are associated with coronary heart disease risk. High CRP in Indigenous Australians has been reported in previous studies including our 'Diabetes and R...

    Authors: Louise J Maple-Brown, Joan Cunningham, Nirjhar Nandi, Allison Hodge and Kerin O'Dea
    Citation: Cardiovascular Diabetology 2010 9:69
    Content type: Original investigation Published on:

  28. This study evaluated the relationship between the G(-866)A polymorphism of the uncoupling protein 2 (UCP2) gene and high-sensitivity C reactive protein (hs-CRP) plasma levels in diabetic patients.

    Authors: Emanuela Lapice, Michele Pinelli, Elisabetta Pisu, Antonella Monticelli, Roberto Gambino, Gianfranco Pagano, Silvia Valsecchi, Sergio Cocozza, Gabriele Riccardi and Olga Vaccaro
    Citation: Cardiovascular Diabetology 2010 9:68
    Content type: Original investigation Published on:

  29. Although exercise training has well-known cardiorespiratory and metabolic benefits, low compliance with exercise training programs is a fact, and the harmful effects of physical detraining regarding these adap...

    Authors: Alexandre M Lehnen, Natalia M Leguisamo, Graziela H Pinto, Melissa M Markoski, Kátia De Angelis, Ubiratan F Machado and Beatriz Schaan
    Citation: Cardiovascular Diabetology 2010 9:67
    Content type: Original investigation Published on:

  30. Advanced glycation products (AGEs), as endogenous inflammatory mediator, compromise the physiological function of mesenchymal stem cells (MSCs). MSCs have a potential role in cell replacement therapy in acute ...

    Authors: Ke Yang, Xiao Qun Wang, Yu Song He, Lin Lu, Qiu Jing Chen, Jing Liu and Wei Feng Shen
    Citation: Cardiovascular Diabetology 2010 9:66
    Content type: Original investigation Published on:

  31. To test the early effect of fructose-induced changes in fatty acid composition and oxidative stress markers in perivascular adipose tissue (PVAT) upon vascular contractility.

    Authors: Alejandro Rebolledo, Oscar R Rebolledo, Carlos A Marra, María E García, Ana R Roldán Palomo, Laura Rimorini and Juan J Gagliardino
    Citation: Cardiovascular Diabetology 2010 9:65
    Content type: Original investigation Published on:

  32. Inflammation of adipose tissue (AT) has been recently accepted as a first step towards obesity-mediated insulin resistance. We could previously show that mice fed with high fat diet (HFD) develop systemic insu...

    Authors: Anna Foryst-Ludwig, Martin Hartge, Markus Clemenz, Christiane Sprang, Katharina Heß, Nikolaus Marx, Thomas Unger and Ulrich Kintscher
    Citation: Cardiovascular Diabetology 2010 9:64
    Content type: Original investigation Published on:

  33. Left ventricular diastolic dysfunction (LVDD) is considered a precursor of diabetic cardiomyopathy, while insulin resistance (IR) is a precursor of type 2 diabetes mellitus (T2DM) and independently predicts he...

    Authors: Wilfried Dinh, Mark Lankisch, Werner Nickl, Daniel Scheyer, Thomas Scheffold, Frank Kramer, Thomas Krahn, Rolf M Klein, Michael Coll Barroso and Reiner Füth
    Citation: Cardiovascular Diabetology 2010 9:63
    Content type: Original investigation Published on:

  34. Interleukin-6 (IL-6) is a multifunctional cytokine regulating humoral and cellular responses and playing a central role in inflammation and tissue injury. Its effects are mediated through interaction with its ...

    Authors: Enrique Z Fisman and Alexander Tenenbaum
    Citation: Cardiovascular Diabetology 2010 9:62
    Content type: Editorial Published on:

  35. Normotensive non-diabetic relatives of type 1 diabetes (T1D) patients have an abnormal blood pressure response to exercise testing that is associated with indices of metabolic syndrome and increased oxidative ...

    Authors: Elena Matteucci, Cristina Consani, Maria Chiara Masoni and Ottavio Giampietro
    Citation: Cardiovascular Diabetology 2010 9:61
    Content type: Original investigation Published on:

  36. Hypertension is an important independent risk factor for renal disease. If hypertension and chronic renal disease co-exist, as is common in patients with diabetes mellitus, the risk of cardiovascular disease i...

    Authors: Eberhard Ritz, Roland E Schmieder and Carol A Pollock
    Citation: Cardiovascular Diabetology 2010 9:60
    Content type: Review Published on:

  37. This study aimed to construct a prediction model to identify subjects with high glycated hemoglobin (HbA1c) levels by incorporating anthropometric, lifestyle, clinical, and biochemical information in a large c...

    Authors: Kuo-Liong Chien, Hung-Ju Lin, Bai-Chin Lee, Hsiu-Ching Hsu and Ming-Fong Chen
    Citation: Cardiovascular Diabetology 2010 9:59
    Content type: Original investigation Published on:

  38. Cardiovascular disease (CVD) risk, although perceived to be high, is often difficult to demonstrate in disease free (healthy) obese adults.

    Authors: Alok K Gupta, Germaine Cornelissen, Frank L Greenway, Vijay Dhoopati, Franz Halberg and William D Johnson
    Citation: Cardiovascular Diabetology 2010 9:58
    Content type: Original investigation Published on:

  39. Thiazolidinediones, used for the treatment of patients with type 2 diabetes mellitus (DM2), are associated with an increased incidence of heart failure. We sought to investigate the effects of pioglitazone on ...

    Authors: Katerina K Naka, Konstantinos Pappas, Katerina Papathanassiou, Nikolaos D Papamichael, Nikolaos Kazakos, Chryssanthi Kanioglou, Demetrios Makriyiannis, Christos S Katsouras, Kostas Liveris, Agathocles Tsatsoulis and Lampros K Michalis
    Citation: Cardiovascular Diabetology 2010 9:57
    Content type: Original investigation Published on:

  40. Early markers of diabetic autonomic neuropathy (DAN) in an electrocardiogram (ECG) include elevated R wave amplitudes, widening of QTc intervals and decreased heart rate variability (HRV). The severity of DAN has...

    Authors: Lisa VanHoose, Youssef Sawers, Rajprasad Loganathan, James L Vacek, Lisa Stehno-Bittel, Lesya Novikova, Muhammed Al-Jarrah and Irina V Smirnova
    Citation: Cardiovascular Diabetology 2010 9:56
    Content type: Original investigation Published on:

  41. Diabetic patients experience exaggerated intimal hyperplasia after endovascular procedures. Recently it has been shown that circulating smooth muscle progenitor cells (SPC) contribute to intimal hyperplasia. W...

    Authors: Peter E Westerweel, Cindy TJ van Velthoven, Tri Q Nguyen, Krista den Ouden, Dominique PV de Kleijn, Marie Jose Goumans, Roel Goldschmeding and Marianne C Verhaar
    Citation: Cardiovascular Diabetology 2010 9:55
    Content type: Original investigation Published on:

  42. The optimum oral pharmacological treatment of diabetes mellitus to reduce cardiovascular disease and mortality following myocardial infarction has not been established. We therefore set out to investigate the ...

    Authors: Casper H Jørgensen, Gunnar H Gislason, Charlotte Andersson, Ole Ahlehoff, Mette Charlot, Tina K Schramm, Allan Vaag, Steen Z Abildstrøm, Christian Torp-Pedersen and Peter R Hansen
    Citation: Cardiovascular Diabetology 2010 9:54
    Content type: Original investigation Published on:

  43. Patients with type 2 diabetes are at an increased risk for disease and treatment related complications after the initial approach of oral mono/dual antidiabetic therapy has failed. Data from clinical practice ...

    Authors: Peter Bramlage, Christiane Binz, Anselm K Gitt, Michael Krekler, Tanja Plate, Evelin Deeg and Diethelm Tschöpe
    Citation: Cardiovascular Diabetology 2010 9:53
    Content type: Study protocol Published on:

  44. The cardiac troponins are biomarkers used for diagnosis of myocardial injury. They are also powerful prognostic markers in many diseases and settings. Recently introduced high-sensitivity assays indicate that ...

    Authors: Jonas Hallén, Odd Erik Johansen, Kåre I Birkeland, Lars Gullestad, Svend Aakhus, Knut Endresen, Solve Tjora, Allan S Jaffe and Dan Atar
    Citation: Cardiovascular Diabetology 2010 9:52
    Content type: Original investigation Published on:

  46. It is very suggestive that diabetic foot is characterized by a pronounced inflammatory reaction and the pathogenic significance of this inflammation has received little attention. On this basis the aim of our ...

    Authors: Antonino Tuttolomondo, Sergio La Placa, Domenico Di Raimondo, Chiara Bellia, Antonietta Caruso, Bruna Lo Sasso, Giovanni Guercio, Giuseppe Diana, Marcello Ciaccio, Giuseppe Licata and Antonio Pinto
    Citation: Cardiovascular Diabetology 2010 9:50
    Content type: Original investigation Published on:

  47. Hyperhomocysteinemia (HHcy) and hyperglycemia cause diabetic cardiomyopathy by inducing oxidative stress and attenuating peroxisome proliferator- activated receptor (PPAR) gamma. However, their synergistic con...

    Authors: Paras K Mishra, Neetu Tyagi, Utpal Sen, Irving G Joshua and Suresh C Tyagi
    Citation: Cardiovascular Diabetology 2010 9:49
    Content type: Original investigation Published on:

  48. Ambigous results exist on fetuin-A as marker for vascular disease in type 2 diabetes. This study aims to define the role of fetuin-A as marker for micro- and macrovascular disease in a high risk population of ...

    Authors: Marcel Roos, Dimitrios Oikonomou, Maximilian von Eynatten, Peter B Luppa, Uwe Heemann, Jens Lutz, Marcus Baumann, Peter P Nawroth, Angelika Bierhaus and Per M Humpert
    Citation: Cardiovascular Diabetology 2010 9:48
    Content type: Original investigation Published on:

  49. Inflammation plays an important role in the pathophysiology of both atherosclerosis and type 2 diabetes and some inflammatory markers may also predict the risk of developing type 2 diabetes. The aims of the pr...

    Authors: Eva C Knudsen, Ingebjørg Seljeflot, Abdelnoor Michael, Jan Eritsland, Arild Mangschau, Carl Müller, Harald Arnesen and Geir Ø Andersen
    Citation: Cardiovascular Diabetology 2010 9:47
    Content type: Original investigation Published on:

  50. Patients with metabolic syndrome (MetS) have an increased risk of cardiovascular disease. Data obtained from muscle biopsies have demonstrated altered insulin signaling (IS) in patients with MetS. The IS regul...

    Authors: Evasio Pasini, Vincenzo Flati, Silvia Paiardi, Damiano Rizzoni, Enzo Porteri, Roberto Aquilani, Deodato Assanelli, Giovanni Corsetti, Silvia Speca, Rita Rezzani, Carolina De Ciuceis and Enrico Agabiti-Rosei
    Citation: Cardiovascular Diabetology 2010 9:46
    Content type: Original investigation Published on:
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ISSN: 1475-2840